Gliclazide MV > Ọgwụgwọ na mgbochi

Gliclazide MV: Ntụziaka maka ojiji na nyocha

Aha Latin: Gliclazide MV

Koodu ATX: A10BB09

Ngwakọta ọrụ: gliclazide (gliclazide)

Onye na-emeputa ihe: LLC Ozon, LLC Atoll (Russia)

Nkọwa na nwelite: 01/14/2018

Ahịa dị n'ụlọ ahịa ọgwụ: site na 81 rubles.

Gliclazide MV bụ ọgwụ nke hypoglycemic ọgwụ.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta Gliclazide MV n'ụdị mbadamba ndị nwere ndọtọ gbanwere: cylindrical, biconvex, ọcha nwere ude ma ọ bụ nke dị ọcha, obere marbling ga-ekwe omume (10, 20 ma ọ bụ iberibe iri atọ na ngwakọta aluminium ma ọ bụ ngwugwu sel kriside polyvinyl, 1, 2, 3, Mpempe akwụkwọ 4, 5, 6, 10 na ngwungwu kaadiboodu, 10, 20, 30, 40, 50, 60, ma ọ bụ 100 PC. Na mpempe plastik, 1 nwere ike na kaadiboodu).

Ngwakọta nke mbadamba 1 gụnyere:

Ihe na-arụ ọrụ: gliclazide - 30 mg,
Ihe ntinye aka: hypromellose - 70 mg, sillofon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Mlọ ọgwụ

Glyclazide bụ ihe dị n'ụsọ sulfonylurea nke nwere ngwongwo hypoglycemic ma bu n'obi maka nchịkwa ọnụ. Ọdịiche ya site na ọgwụ ọjọọ na ụdị a bụ ọnụnọ nke nwere heterocyclic mgbanaka N-nwere njikọ endocyclic.

Gliclazide na-ebelata glucose ọbara, na-akwalite mmepụta insulin site na mkpụrụ ndụ beta nke agwaetiti Langerhans. Nnukwu ịba ụba nke C-peptide na postprandial insulin na-adịgide ka afọ nke ọgwụgwọ 2 gasịrị. Dị ka ọ dị n'ihe ndị ọzọ sitere na usoro sulfonylurea, mmetụta a bụ n'ihi nzaghachi ike nke β-sel nke agwaetiti nke Langerhans maka mkpali glucose, a na-arụ dị ka ụdị physiological si dị. Ọ bụghị nanị na Gliclazide na-emetụta metabolism metabolism, kamakwa ọ na-akpalite mmetụta hemovascular.

N'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke gelllazide, gliclazide na-enyere aka weghachite mbido mbụ nke mmepụta insulin, nke bụ nsonaazụ nke glucose ma na-akpali usoro nke abụọ nke nzuzo insulin. Nnukwu mmụba na njikọta insulin na-ejikọ ya na nzaghachi maka mkpali kpatara glucose ma ọ bụ oriri nri.

Ojiji nke gliclazide na-ebelata ihe ize ndụ nke imepụta obere akpa arịa ọbara, na-eme ihe ndị nwere ike ịkpalite mmepe nke nsogbu na ndị ọrịa nwere ọrịa mellitus, mbelata ọdịnaya nke ihe na-eme ka platelet (thromboxane B₂, beta-thromboglobulin), ihe mgbochi nke platelet adhesion na nchịkọta, yana imetụta mweghachi nke fibrinolytic sistemu nke vaskụla endothelium, na ụba ọrụ nke plasminogen, nke bụ ihe na-eme ka anụ ahụ rụọ ọrụ.

Ojiji nke glycazide gbanwere, ebumnuche glycosylated hemoglobin (HbAlc) erughị 6.5%, na njikwa glycemic siri ike dabere na nnwale ụlọ ọgwụ a pụrụ ịdabere na ya, nwere ike belata ihe egwu macro- na nsogbu microvascular na-eso ụdị ọrịa shuga 2 tụnyere ọrịa glycemic ọdịnala njikwa.

Mmejuputa ikike ogwu glycemic siri ike mejuputara gliclazide (nkezi kwa ubochi bu 103 mg) na iwelie onodu ya (ihe ruru 120 mg kwa ubochi) mgbe ị na-eme usoro ọgwụgwọ na ndabere (ma ọ bụ kama) tupu ịgbakwunye ya hypoglycemic ọgwụ (dịka ọmụmaatụ, insulin, metformin mkpụrụ osisi thiazolidinedione, alfa glucosidase inhibitor). Ojiji gliclazide na otu ndị ọrịa nọ na-ahụ maka nchịkwa glycemic siri ike (na nkezi, uru HbAlc bụ 6.5% na nkezi oge nlegide bụ afọ 4.8), ma e jiri ya tụnyere ìgwè ndị ọrịa na-enwe njikwa ọkọlọtọ (nkezi HbAlc uru bụ 7.3% ) ekwenti na nsogbu nsogbu nwude nsogbu nke micro- na macrovaskụla belatara nke ukwuu (site na 10%) n'ihi mbelata dị egwu na nsogbu ọghọm microvascular nsogbu (site na 14%), ugboro Itijah na progression nke microalbuminuria (9%), gbasara akụrụ nsogbu (11%), mmalite na progression nke nephropathy (21%), na mmepe nke macroalbuminuria (30%).

Mgbe ị na-edepụta gliclazide, njikwa glycemic siri ike nwere uru dị ukwuu nke anaghị ekpebi nsonaazụ nke ọgwụgwọ na ọgwụ antihypertensive.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, glycoside na-etinye obi gị dum na ngari nri site na 100%. Ihe dị n'ime ya na plasma ọbara na-abawanye nwayọ n'ime awa isii mbụ, ntinye ahụ na-akwụsi ike ruo awa 6-12. Ogo ma ọ bụ ogo nke nnabata gliclazide bụ ihe oriri n’onweghị.

Ihe dị ka 95% nke ihe na-arụ ọrụ na-ekekọta protein protein. Olu nke nkesa dị ihe dịka 30 lita. Ceptionnabata Gliclazide MV na usoro 60 mg otu ugboro kwa ụbọchị na-enye gị ohere ịnwe ntinye ọgwụgwọ gliclazide na plasma ọbara ruo awa 24 ma ọ bụ karịa.

Metabolism nke Gliclazide na-aputa ihe na mbu na imeju. Achọghị ọgwụ metabolites na-arụ ọrụ nke ọgwụ a na plasma. A na - ekepụta Gliclazide site na akụrụ n'ụdị metabolites, ihe dịka 1% apụtaghị na mmamịrị ahụ. Oge ndụ ọkara bụ awa iri na isii (ihe ngosi nwere ike ịdị iche site na awa iri na abụọ ruo iri abụọ).

Edere mmekọrịta kwụ ọtọ n’etiti ọgwụ a nabatara maka ọgwụ a (ọ karịrị ihe karịrị 120 mg) na mpaghara dị n’okpuru usoro ụlọ ọgwụ ọgwụ “ịta - oge”. N'ime ndị ọrịa agadi, enweghị mgbanwe mgbanwe dị ukwuu na ụlọ ọgwụ n'usoro ọgwụ.

Ihe ngosi maka ojiji

Dịka ntuziaka ahụ si dị, enyere ọgwụ Gliclazide MV maka ọgwụgwọ nke ogo ọrịa shuga nke ọrịa shuga nke abụọ (na-abụghị insulin) na mmalite ngosipụta microangiopathy mamịrị.

A na-ejikwa ọgwụ ahụ iji gbochie nsogbu microcirculatory (n'otu oge ya na usoro ndị ọzọ na-esi na sulfonylurea).

Ihe ngbanwe

1dị 1 nke ọrịa shuga mellitus (insulin-dependance),
Ọrịa ndị na-emetụta oke umeju na akụrụ,
Ketoacidosis
Ọrịa mamịrị na precoa
Ejiri nkwekọrịta na imidazole (gụnyere miconazole),
Hypersensitivity na sulfonamides na sulfonylureas.

A naghị akwado iji Glyclazide MV maka ụmụ nwanyị na-ete nwa na ụmụ nwanyị dị ime.

Ntụziaka maka iji Gliclazide MV: usoro na usoro onunu ogwu

A na -ekwu Gliclazide MV tupu nri.

Ọtụtụ ọgwụ ị theụ ọgwụ ahụ bụ ugboro 2 n'ụbọchị.

Dọkịta na-ekpebi ọgwụ ụbọchị ọ bụla n'otu n'otu, dabere na ngosipụta nke ọrịa na ọrịa mgbatị, na afọ na-enweghị isi na awa 2 mgbe nri gasịrị.

Dịka iwu, usoro izizi bụ 80 mg kwa ụbọchị, nkezi nkezi bụ 160-320 mg kwa ụbọchị.

Nsonaazụ

N'oge eji Gliclazide MV, enwere ike ibute nsogbu site na ụfọdụ usoro ahụ:

Usoro digestive: adịkarịghị - ọgbụgbọ, anorexia, afọ ọsịsa, vomiting, ihe mgbu epigastric,
Usoro endocrine: na nnabata - hypoglycemia,
Usoro nke Hematopoietic: n'ọnọdụ ụfọdụ - thrombocytopenia, leukopenia ma ọ bụ agranulocytosis, anaemia (nke a na-atụgharịkarị),
Mmeghachi omume nfụkasị: itching, ọnya anụ ahụ.

Dodoụbiga ya ókè

Dodoụfe oke MV Glyclazide nwere ike ịkpasu mmepe nke hypoglycemia, na n'ọnọdụ ndị siri ike, hypoglycemic coma.

A na-agbazi mgbaàmà nke ogo hypoglycemia na-erughị ala site na mgbanwe nri, nhọrọ nke ọgwụ na / ma ọ bụ oriri na-egbu carbohydrate. Ekwesịrị iji nlezianya nyochaa ọnọdụ onye ọrịa ahụ ruo mgbe enwere ike ibute ndụ na ahụike ka ọ dịgide. Ọnọdụ hypoglycemic siri ike nwekwara ike ịmalite, jikọtara ọdịdọ, coma, ma ọ bụ nsogbu ndị ọzọ nke usoro ụjọ ahụ. Ọ bụrụ na ụdị mgbaàmà ndị a mere, a na-atụ aro ka e lebara ahụike mberede anya ma chọọ ụlọ ọgwụ.

Ọ bụrụ na a chọpụta onye ọrịa ahụ na hypoglycemic coma ma ọ bụ enyo enyo na ọ nwere ya, ekwesịrị ka enye ya (intravenously, jet) 50 ml nke 40% glucose ngwọta (dextrose). Mgbe nke ahụ gasị, a ga - etinye ntụtụ 5% dextrose n'ime intravenly, nke ga - enyere gị aka ịchekwa mkpa glucose dị n'ọbara (ọ bụ ihe dịka 1 g / l) Ekwesịrị iji nlezianya nyochaa ọbara glucose na onye ọrịa ahụ ka ọ na-elele onye ọrịa ahụ ọ dịkarịa ala ụbọchị 2 mgbe ọ nwesịrị ịdoụbiga mmanya ókè. Ọnọdụ ya kpebisikwuo ike mkpa nyocha nke ọrụ dị mkpa nke onye ọrịa.

Ebe ọ bụ na gliclazide na-ejikọ protein dị ukwuu na plasma, usoro ọgwụgwọ adịghị arụ ọrụ.

Ntụziaka pụrụ iche

Na ọgwụgwọ nke ọrịa mellitus na-abụghị insulin na-akpata, a ga-eji Gliclazide MV n'otu oge yana nri nwere obere kalori nwere obere carbohydrates.

N'oge usoro ọgwụgwọ, ịkwesịrị ileba anya n'ihe ọmụmụ kwa ụbọchị na ọkwa glucose, yana ọkwa glucose n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri.

Site na usoro ịwa ahụ ma ọ bụ ịgwọ ọrịa shuga mellitus, enwere ike ịtụle ọgwụ insulin.

N'ihe banyere hypoglycemia, ọ bụrụ na onye ọrịa maara, a ga-eji ọnụ gluga (ma ọ bụ mmiri shuga). N'ọnọdụ nke mmụọ, akpịrị ga-achịkwa glucose (intravenously) ma ọ bụ glucagon (subcutaneously, intramuscularly or intravenously). Iji zere ịmaliteghachi hypoglycemia mgbe mweghachi nke nsụhọ, ekwesịrị inye onye ọrịa ahụ nri nwere carbohydrate.

Ekwesighi iji gliclazide n'otu oge na cimetidine.

Site na iji gliclazide na verapamil jikọtara ọnụ, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose n'ọbara, yana acarbose, iji nlezianya nyochaa ma mezie usoro nchịkwa nke ndị na-ahụ maka hypoglycemic dị mkpa.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Ndị ọrịa na-ewere Glyclazide MV kwesịrị ịma banyere mgbaàmà nke hypoglycemia ma dọọ aka ná ntị banyere mkpa ọ dị ịkpachara anya mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ụfọdụ ọrụ chọrọ mmeghachi omume psychomotor ozugbo, karịsịa na mmalite ọgwụgwọ.

Isi izugbe nke ọgwụ

Gliclazide MV bụ ihe nnọchite ọnụ nke bụ ihe na-esite na usoro nke abụọ n'ọgwụ sulfonylurea. Ejirila nkwadebe nke otu a ogologo oge na usoro ọgwụgwọ, malitere na 1950s. N'oge a na-alụ Agha werewa nke Abụọ, e ji ọgwụ ndị a lụ ọgụ ọrịa dị iche iche, ma ọ bụ naanị na mberede ka a chọpụtara mmetụta hypoglycemic ha.

Mba nke imepụta ọgwụ bụ Russia. Glyclazide MV 30 mg na mbadamba ụyọkọ bụ naanị ụdị usoro onunu ogwu nke ụlọ ọrụ ọgwụ na-emepụta. Acronym MB na - anọchi ntọhapụ Modified. Nke a pụtara na MV mbadamba nkume na-abanye n’ime afọ ruo awa atọ, wee banye n’afere ọbara ma belata mkpụkọ glucose dị n’ọbara. Drugsdị ọgwụ ahụ nwere mmetụta dị nro na mbelata shuga, yabụ, o yikarịrị ka ha iduga ọnọdụ hypoglycemia (naanị 1% nke ikpe).

Ọgwụ Gliclazide MV n'oge eji arụ ọrụ ahụ nwere ezigbo mmetụta dị mma n'ahụ ahụ onye ọrịa:

Ọ na-akpalite mmepụta insulin site na pancreas.
Na-ebelata ọbara shuga.
O nwere nnabata insulin nke glucose.
Na - eme ka anụ ahụ sie ike na homonụ.
Na-eme ka ọkwa glycemia dị na afọ na-enweghị isi.
Na-ebelata mmepụta glucose umeji.
Emetụta microcirculation na carbohydrate metabolism.

Na mgbakwunye, ọgwụ a na-ebelata ohere nke ọbara ọgbụgba n'ime arịa.

Ntuziaka maka iji ọgwụ ahụ

N'okwu a, enweghị ike ị -ụ ọgwụ onwe ya, naanị dọkịta, mgbe ọ tụlesịrị uru ọgwụ dị yana nsị ọ na-arịa ahụ onye ọrịa, nwere ike ịdebe mbadamba nkume Glyclazide MV.

Mgbe ị gachara dọkịta, ịkwesịrị ịzụta ọgwụ ndenye ọgwụ, ngwugwu nke enwere 60 mbadamba. A na-eji ọgwụ ahụ eme ihe n'ọnọdụ ndị a:

Na ọgwụgwọ nke ọrịa shuga na-adịghị insulin, mgbe nri kwesịrị ekwesị na mmega ahụ enweghị ike ịnagide mbelata mgbanye glucose ọbara.
Maka mgbochi nke nsonaazụ nke pathology - nephropathy (arụ ọrụ akụrụ) yana retinopathy (mbufụt nke retina nke nku anya).

Ntụziaka maka iji ya nwere ozi niile dị mkpa gbasara mbadamba nkume ndị ịchọrọ iji nlezianya gụọ. Usoro ọgwụgwọ maka ndị ọrịa na-amalite ọgwụgwọ naanị, yana maka ndị gbara afọ 65 bụ mg mg 30 kwa ụbọchị. Ha na-eripịa n’oge nri ụtụtụ. Ka izu abụọ nke ọgwụgwọ ahụ gasịrị, dọkịta ahụ kpebiri ma ọ̀ ga-amụba ọ̀gwụ a. Ihe abuo na - emetụta nke a - ndị na - egosi glucose na ogo nke ọrịa shuga. N'ozuzu, ọgwụ ahụ dịgasị iche site na 60 ruo 120 mg.

Ọ bụrụ na onye ọrịa ahụfuru ị theụ ọgwụ, mgbe ahụ okpukpu abụọ ekwesịghị ịnwe ya n'ọnọdụ ọ bụla. Ọ bụrụ na ịchọrọ ịgbanwe ihe Gliclazide MV na ọgwụ ndị ọzọ na-ebelata shuga, mgbe ahụ ọgwụgwọ ahụ ga-agbanwe site n'echi ya. Njikọ a ga - ekwe omume na metformin, insulin, yana alhib glucosidase inhibitors. Ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ruo na-agafeghị oke were otu usoro ahụ. Ndị ọrịa ahụ nọ n'ihe ize ndụ nke hypoglycemia na-eji ọgwụ ahụ nwere ntakịrị usoro.

E kwesịrị ichebe mbadamba ebe ebe ụmụaka na-enweghị ike iru, na ikuku ikuku na-erughị 25C. Ọgwụ dị mma maka afọ atọ.

Mgbe ọ gwụsịrị, a machibidoro iji ya iwu.

Akwụ ụgwọ na analogues nke ọgwụ

Ebe obu na ndi ulo na emeputa ogwu a, onu ahia ya adighi elu. Enwere ike zụta ọgwụ ahụ n'ụlọ ahịa ọgwụ ma ọ bụ nye iwu na ntanetị n'ụlọ ahịa dị n'ịntanetị, ebe ị na-enye ndenye ọgwụ dọkịta. Ọnụ ego ọgwụ Gliclazide MV (30 mg, 60 iberibe) sitere na 117 ruo 150 rubles. N'ihi nke a, onye ọ bụla nwere ego ọ ga-akwụ ga-akwụli ya.

Mmeghari nke ogwu a bu ogwu nke nwekwara ihe ndi gliclazide. Ndị a gụnyere Glidiab MV, Diabeton MV, Diabefarm MV. O kwesiri iburu n’obi na mbadamba MV Diabeton (30 mg, 60 iberibe) di oke onu ahia: onu ego di 300 rubles. Nsonaazụ ọgwụ ọgwụ ndị a bụ otu.

N'ọnọdụ nke onye ọrịa ahụ nwere contraindications nke ọgwụ gliclazide ma ọ bụ ọgwụ ahụ na-emerụ ahụ, dọkịta ga-agbanwe usoro ọgwụgwọ. Iji mee nke a, ọ nwere ike ịnye ọgwụ ọgwụ yiri nke a, nke ga-ewetakwa nsonaazụ hypoglycemic, dịka ọmụmaatụ:

Amaryl M ma ọ bụ Glemaz nwere glimepiride dị n'ọrụ,
Glurenorm nwere ike glycidone,
Maninil nwere glibenclamide nọ n'ọrụ.

Nke a bụ ndepụta ezughị ezu nke analogues niile, enwere ike ịchọta ozi zuru ezu na Internetntanetị ma ọ bụ jụọ dọkịta gị.

Onye ọrịa ọ bụla na-ahọrọ ọgwụgwọ kachasị mma dabere na ihe abụọ - ọnụahịa na nsonaazụ ọgwụgwọ.

Echiche ndị ọrịa banyere ọgwụ

N'ụbọchị ndị a, a na-eji ọgwụ ndị sitere na usoro nke ọgbọ abụọ sulfonylurea, gụnyere ọgwụ Gliclazide MV. Nke a bụ n'ihi n'eziokwu na agbanyeghị ọgwụ nwere ọtụtụ mmetụta, ọ na-adịkarị obere.

Ihe omumu sayensi egosiputala uto oma nke ogwu n’enwe microcirculation. Na mgbakwunye, ọgwụ ahụ na-egbochi mmepe nke ọtụtụ nsogbu:

nje microvascular - retinopathy na nephropathy,
ọrịa shuga microgoniopathy,
mụbara nri,
mfu nke akwara vaskụla.

N'icheta nyocha nke ọtụtụ ndị ọrịa, anyị nwere ike ịkọwa ụfọdụ ndụmọdụ maka iji ọgwụ ahụ:

Mpekere ka mma iri nri ụtụtụ,
nri ụtụtụ kwesịrị ịdị elu na carbohydrates,
ị gaghị agụ agụụ ụbọchị niile,
mgbe ị na-enwe nsogbu anụ ahụ, ịkwesịrị ịgbanwe usoro ọgwụgwọ.

Ọzọkwa, nyocha nke ụfọdụ ndị ọrịa mamịrị na-egosi na ịgbaso nri kalori na ịme mgbatị anụ ahụ nwere ike ịkpata hypoglycemia. Nke a metụtakwara ndị na-a alcoholụ mmanya mgbe ha na-a pụ ọgwụ. Ihe ọghọm nke mbelata ọbara shuga dị n'ọbara ndị okenye.

Ndị ọrịa mamịrị na-ahapụ okwu ha na ọgwụ dị mma iji ya tụnyere gliclazide ot, usoro nke ya okpukpu abụọ buru ibu. Otu ugboro kwa ụbọchị na-enye nsonaazụ nwayọ ma dị irè, na-ebelata ọkwa glucose na-aga nke ọma. Agbanyeghị, enwere ọnọdụ na mgbe ị ofụ ọgwụ ahụ ogologo oge (ihe dị ka afọ 5), mmetụta ya ghọrọ adịghị ike, dọkịta ahụ dekwara ọgwụ ndị ọzọ iji dochie Gliclazide MV kpamkpam ma ọ bụ maka ọgwụgwọ dị mgbagwoju anya.

Gliclazide MV bụ ezigbo ọgwụ hypoglycemic nke na - eji nwayọ belata shuga ọbara. Ọ bụ ezie na o nwere ụfọdụ contraindications na mmetụta ndị dị na ya, ihe ize ndụ nke mmeghachi omume na-adịghị mma bụ 1%. Onye ọrịa ahụ ekwesịghị ịgwọ onwe ya ọgwụ, naanị dọkịta, na-eburu n'uche njirimara onye ọrịa ahụ nwere ike ịkọwapụta ọgwụ dị irè. Na ọgwụgwọ nke ụdị ọrịa shuga 2 ụdị mellitus site n'enyemaka nke Gliclazide MV, ọ dịkwa mkpa ịgbaso ezigbo nri na-ebi ndụ na ndụ. Ya mere, na-edebe iwu niile, onye ọrịa ahụ ga-enwe ike idobe ọrịa a na "oke aka uwe" ma gbochie ya ịchịkwa ndụ ya!

Enyere ozi na Gliclazide MV na vidiyo dị n'isiokwu a.

Glyclazide, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Mbadamba nke Glyclazide N'usoro ọgwụ mbido 80 kwa ụbọchị, ugboro 2 n’ụbọchị 30 nkeji tupu nri. N’ọdị n’ihu, a na-agbazi ọgwụ a na-agbaso, kwa ụbọchị ị na-eri kwa ụbọchị bụ 160 mg, ma kacha bụ 320 mg. Mbadamba ụrọ Glyclazide MB nwere ike ịhụ mbadamba mbugharị oge niile. Ọ bụ dọkịta ga-ekpebi ihe ga-ekwe omume ma dochie ya na ọgwụ a.

Glyclazide MB 30 mg iri oge 1 n’oge nri ụtụtụ. A na-amalite ịgbanwe ọgwụ mgbe izu 2 gachara. Ọ nwere ike ịbụ 90 -120 mg.

Ọ bụrụ na ọgwụ gị riri gị ọgwụ, ị gaghị anara ya okpukpu abụọ. Mgbe ị ga-eji nke a dochie ọgwụ belata shuga ọzọ, oge mgbanwe agaghị achọ ya - ha ga - ebido were ya echi. Ikekwe ngwakọta na biguanides, insulinalfa glucosidase inhibitors. Maka nwayọọ gbasara akwara họpụtara n'otu usoro onunu ogwu. N'ime ndị ọrịa nwere ọrịa hypoglycemia, a na-eji ntakịrị ọgwụ.

A na - egosipụta njupụta mgbanwe site na mgbaàmà hypoglycemia: isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụgharị, palpitations, ọbara mgbali elu, arrhythmiairo ụra mkpasu iweiwe, oke iwe, mmeghachi omume na-egbu oge, ọhụụ na-enweghị isi na okwu, ịma jijijianya ntughari ogwe, bradycardiaọnwụ nke mmụọ.

Na agafeghị oke hypoglycemiana-enweghị mmụọ ịta ahụhụ, belata dose nke ọgwụ ma ọ bụ nwekwuo ego nke carbohydrates na-enye nri.

Na ọnọdụ hypoglycemic siri ike, ịga ụlọ ọgwụ ozugbo na enyemaka dị mkpa: iv 50 ml nke 20 gụrụ 20-30% gluuze, mgbe ahụ, 10% dextrose ma ọ bụ gluuze mmiri na-atasị. N'ime ụbọchị abụọ, a na-enyocha ọkwa glucose. Dialysis adighi ike.

Jiri ya mee ihe Cimetidinenke na-abawanye ịta ahụhụ gliclazidenke ahụ nwere ike ibute nnukwu hypoglycemia.

Mgbe etinyere ya na Verapamil ịkwesịrị ijikwa ọkwa nke glucose.

A na - eme ka hypoglycemic mmetụta mgbe ejiri ya salicylatesusoro Pyrazolone, sulfonamides, kafiin, Phenylbutazone, Theophylline.

Ojiji nke ndị na - egbochi beta na - ahọrọ ihe a na - ebute nsogbu ahụ hypoglycemia.

Mgbe itinye akwụkwọ Acarboseakara mmado hypoglycemic akara.

Mgbe ị na-eji GCS (gụnyere ụdị ngwa ọzọ). mgbochi ego, diuretics, estrogenna progestins, Diphenin, Rifampicinmmetụta belata shuga nke ọgwụ a.

Mgbe okpomọkụ na-erughị 25 C.

Glidiab MV, Glyclazide-Akos, Diabinax, Diabeton MV, Diabetalong, Glucostabil.

Ka ọ dị ugbu a, usoro eji eme ihe n'ọtụtụ ebe. ọgbọ nke abụọ sulfonylureas, nke Gliclazide bụ, n'ihi na ha dị elu karịa ọgwụ ọjọọ nke ọgbọ gara aga na ịdị ike nke mmetụta hypoglycemic, ebe ọ bụ na njikọta nke ndị nabatara β-cell dị ugboro 2-5 karịa, nke na-enye ohere iji nweta nsonaazụ mgbe ị na-edepụta obere usoro. Ọgbọ a ọgwụ adịghị yikarị ịkpata nsonaazụ.

Otu akụkụ nke ọgwụ ahụ bụ na etolite ọtụtụ metabolites n'oge mgbanwe metabolic, na otu n'ime ha nwere mmetụta dị ukwuu na microcirculation. Ọtụtụ ọmụmụ egosila na enwere ihe ọghọm nke nsogbu microvascular (retinopathyna nephropathy) na ọgwụgwọ gliclazide. Ogo-ebelata angiopathy, oriri na-edozi ahụ na-adịwanye mma, na-apụ n'anya vaskụla stasis. Ọ bụ ya mere e ji nye ya ọgwụ maka nsogbu ọrịa shuga mellitus (angiopathy, nephropathyna mbu nwa akuko okpu, retinopathies) a na-akọkwara nke a site n'aka ndị ọrịa bufere nke a, zigara ya ị takingụ ọgwụ a.

Ọtụtụ na-ekwusi ike na a ga-ewere mbadamba mgbe nri ụtụtụ gasịrị, nke nwere carbohydrates zuru oke, agụụ maka ụbọchị adịghị anabata. Ma ọ bụghị ya, megide nri dị kalori dị ala na mgbe ọ gbasasịrị nnukwu ahụ ike, enwere ike mmepe hypoglycemia. Site na nrụgide anụ ahụ, ọ dị mkpa ịgbanwe dose nke ọgwụ. Mgbe ha drinkingụsịrị mmanya, ụfọdụ ụfọdụ nwekwara ọnọdụ nke ịba ụba.

Ndị okenye na-elebara ọgwụ hypoglycemic anya karịsịa, ebe ọ bụ na ihe egwu ha nwere ịba ụba hypoglycemia mụbara. Na njikọ a, ọ kaara ha mma iji ọgwụ adịghị eme ihe (ọ dị mma gliclazide).
Ndị ọrịa na-achọpụta na nyocha ha banyere ịdị mma nke iji mbadamba ihe eji emegharị emezi: ha na-eme nwayọ na nha, yabụ a na-eji ya otu ugboro n'ụbọchị. Na mgbakwunye, ogo ya dị irè ji okpukpu abụọ dị ala karịa ihe ị na-eme gliclazide.

Enwere akụkọ na mgbe ọtụtụ afọ (site na 3 ruo 5 site na mmalite nke oriri), nguzobe malitere - mbelata ma ọ bụ enweghị ọrụ nke ọgwụ ahụ. N'ọnọdụ ndị dị otú ahụ, dọkịta ahụ họọrọ njikọ nke ndị ọzọ hypoglycemic na-elekọta mmadụ.

You nwere ike ịzụta ọgwụ ahụ na netwọ ọgwụ nke obodo niile nke Russia: Ryazan, Tula, Saratov, Ulyanovsk.

Kedu ka ọgwụ si arụ ọrụ?

Mmetụta ọgwụ ahụ bụ hypoglycemic. Na-eme ka mmiri ọgwụ insulin na-abawanye site na mkpụrụ ndụ beta nke pancreatic ma melite itinye glucose. Na-akpali ọrụ nke akwara glycogen synthetase. Irè na metabolic latent latent mellitus, na ndị ọrịa nwere oke ibu usoro iwu. Gliclazide na-eme ka profaịlụ glycemic pụta mgbe ọtụtụ oge ọgwụgwọ gasịrị.

Glyclazide na-eme ka oge dị mkpirikpi malite na mgbe mmiri butere insulin insulin, weghachite mbido insulin nke mbụ, ma belata hyperglycemia kpatara nri.

Dị Mkpa! Ọ na - eme ka ọgwụ mgbochi ala dị mma, akụrụngwa nke ọrịa rheological, ọbara ọbara na usoro microcirculation.

Gliclazide na - egbochi mmepe nke microvasculitis, gụnyere ihe mebiri emebi nke anya. Ọ na - egbochi nchịkọta platelet, na - eme ka njikọta nke adịghị n'otu dịkwuo elu, na - eme ka heparin na ọrụ fibrinolytic dịkwuo elu, ma na - eme ka nkwụghachi nke heparin dịkwuo elu. Ọ na-egosipụta akụrụngwa antioxidant, na-eme ka vasculari na-emekọ njikọ, na-eme ka ọbara na-aga n'ihu na microvessels, na-ewepụ ihe ịrịba ama nke microstasis.

Na nephropathy mamịrị, ọgwụ ahụ na-ebelata proteinuria. Were mmiri zuru oke na ngwa ngwa. N'ime imeju, ọ na - eme oxidation site na nguzobe metabolites, otu n'ime ha nwere mmetụta akpọ microcirculation. A na - apịpụta ya n'ụdị metabolites na mmamịrị ma site na ngiri nri.

Ntụziaka zuru ezu maka ojiji

Ọgwụ nke mbụ maka ndị ọrịa ruru afọ 65 bụ 80 mg / ụbọchị, n'ime usoro abụọ kewara, maka ndị ọrịa karịrị afọ 65, ọgwụgwọ kwesịrị ịmalite site na 40 mg 1 r / ụbọchị Ọ bụrụ na ọ dị mkpa, ekwesịrị ịbawanye njikwa glycemic. Enwere ike ịbawanye ọgwụ kwa ụbọchị na BPF (nkwanye maka iji ọgwụ ọjọọ na Britain Mpempe Nha, Isi 60).

A na-atụ aro ka iwelie onyonyo a ka ọ dịkarịa ala ụbọchị iri na anọ, nkezi kwa ụbọchị bụ 80-240 mg na usoro onyonyo abụọ, ọ̀tụ̀tụ̀ ọkọlọtọ bụ 160 mg / ụbọchị nke BNF na usoro abụọ, oke kachasị kwa ụbọchị bụ 320 mg nke BNF Glyclazide na usoro abụọ.

Maka mbadamba mbugharị ndị gbanwere, ọgwụ a tụrụ aro ka amalite bụ 30 mg. Thebọchị kwa ụbọchị bụ 30-120 mg, a na-ewere kwa ụbọchị otu ugboro n’oge nri ụtụtụ.

Ekwesịrị ị tabletsụ mbadamba nkume ndị ahụ kpamkpam, ọ bụrụ na ọ dị mkpa iji wusie ike nchịkwa glycemia, enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 60 mg, 90 mg ma ọ bụ 120 mg otu ugboro n'oge nri ụtụtụ, a na-atụ aro ka iwelie dose ahụ nke nta nke nta, na oge nke ọnwa 1, ewezuga mgbe enwere mgbanye glucose na ọbara n'ime izu abụọ nke ọgwụgwọ.

N'ọnọdụ ndị dị otú a, enwere ike ịbawanye dose ahụ mgbe izu abụọ nke ọgwụgwọ gasịrị, nkezi nkezi kwa ụbọchị bụ 60 mg / ụbọchị otu ugboro.

Dị Mkpa! Tupu ịbawanye ọgwụ kwa ụbọchị, gwọọ dọkịta gị.

N'oge nri ụtụtụ, maka ọtụtụ ndị ọrịa site na mmalite ọgwụgwọ, ọgwụ a na-atụ aro ka ukwuu kwa ụbọchị bụ mbadamba 120 mg 1. (Mbadamba ụrọ) na ntọhapụ nke ọgwụ 60 mg bụ ihe dị ka mbadamba nkume abụọ na ntinye ọgwụ gbanyere 30 mg nke tebụl.

Mbadamba ndị nwere usoro ọgwụ ọgwụ 60 mg gbanwechara agbadoro n'okpuru akụkụ, nke a na-eme ka o kwe omume iji ọgwụ ahụ mee ihe na 30 mg (tebụl 1/2.) Yana na 90 mg (okpokoro 1.5).

Nyefee onye ọrịa site na nkwadebe nwere Glyclazide 80 mg na nkwadebe nwere mbadamba mbugharị Gliclazide 60 mg gbadara mbadamba: 1 mbadamba 1 nke nwere Glyclazide 80 mg kwekọrọ na tebụl 1/2. ọgwụ a bụ 60 mg.

Etu ị ga-esi mee n’oge afọ ime

N'oge ime, Glyclazide bụ contraindicated, ya mere ojiji a oge na lactation bụ ukwuu achọghị.

Agbanyeghị n'oge ịtụrụ ime, enwere ike ịnabata ọnọdụ glucose, nke nwere ike ibute nsonaazụ anaghị enye ọ pleasantụ nke ukwuu mgbe ị na-eji Glyclazide n'oge ime. Ya mere, n’oge ime, a na-atụ aro ime nnwale nnabata glucose.

Na ọrịa shuga, ọ dị ezigbo mkpa ịdị na-enyocha ọkwa shuga dị n'ọbara, nke glucometer nwere ike inyere aka, nke a kọwara n'ụzọ zuru ezu n'isiokwu ahụ "Nkọwa zuru ezu nke Accu-Chek Active glucometer".

Ime na lactation

Enweghị ahụmịhe banyere nhọpụta nke Gliclazide MV nye ụmụ nwanyị dị ime. Mmụta n'ime anụmanụ anabataghị ọnụnọ nke njiri teratogenic. Na enweghi ụgwọ zuru oke maka ọrịa mellitus n'oge ọgwụgwọ, enwere ihe ọghọm nke ibute ọrịa afọ na - ebu n'afọ, nke nwere ike belata nchịkwa zuru oke. Kama gliclazide n'ime ụmụ nwanyị dị ime, a na-atụ aro iji insulin, nke bụkwa ọgwụ ịhọrọ maka ndị ọrịa na-eme atụmatụ ịtụrụ ime, ma ọ bụ ndị tụụrụ ime n’oge ọgwụgwọ Gliclazide MV.

Ebe ọ bụ na enweghị ozi banyere ị ofụ ọgwụ ike na-arụ ọrụ n'ime mmiri ara, na ụmụ amụrụ ọhụrụ enwere ihe ọghọm nke ịmalite hypoglycemia neonatal, na-ewere Gliclazide MB n'oge a na-enye nwa ara.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Site na usoro digestive, Glyclazide nwere ike ibute: adịkarịghị - anorexia, ọgbụgbọ, vomiting, afọ ọsịsa, mgbu epigastric.
Site na usoro hemopoietic: n'ọnọdụ ụfọdụ - thrombocytopenia, agranulocytosis ma ọ bụ leukopenia, anaemia (nke a na-atụgharịkarị).
Site na usoro endocrine: na ị anụbiga mmanya ókè - hypoglycemia.
Mmeghachi omume nfụkasị: ọnya anụ ahụ, itching.

A na - egosipụta oke nrịba ama site na ngosipụta nke hypoglycemia: isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụsọ, palpitations, ọbara mgbali elu, arrhythmia, iro ụra, mkpasu iwe, iwe, iwe iwe, mmeghachi omume oge, ọhụhụ ụzọ na okwu, mkpọtụ, dizzness, mgbu, bradycardia, ọnwụ nke nsụhọ.

Otu n'ime ihe mgbawa kachasị njọ bụ coma.

Dị Mkpa! Mgbe ị na-eji ọgwụ ọjọọ, ị ga-enyocha ọnọdụ gị.

Site na hypoglycemia dị ala na-enweghị mmetụ ọfụma, belata ọgwụ ahụ ma ọ bụ nwekwuo carbohydrates na-enye nri.

Analogs na ọnụahịa

Ihe ana - eme Gliclazide bu:

Vero-Glyclazide,
Glidiab
Glidiab MV,
Glisid
Gliclazide MV,
Glyclazide-Akos,
Glioral
Glucostabil,
Diabest
Diabetalong
Ọrịa mamịrị
Diabeton MV,
Diabefarm
Diabefarm MV,
Diabinax
Diabresid
Diatik
Medoclacid
Predian
Ntugharị.

Nwere ike ịzụta ọgwụ ahụ na netwọọ ahịa ọgwụ nke obodo niile nke Russia.

Enwere ike ịzụta Glyclazide MV 30 mg maka 115-147 rubles.

Site n'isiokwu a, ị nwere ike ịmụtakwu banyere ọgwụ ndị nwere ọrịa shuga ọhụụ.

Nyocha banyere ọrịa mamịrị

Ka ọ dị ugbu a, usoro nke sulfonylureas nke ọgbọ nke II, nke Gliclazide bụ nke, ka a na-eji karịa n'ihi na ha karịrị ọgwụ ọjọọ nke ọgbọ gara aga na ogo hypoglycemic mmetụta, ebe ọ bụ na njikọta nke ndị nabatara β-cell na-enweta 2-5 ugboro karịa, nke na-enye ohere iji nweta nsonaazụ mgbe ị na-edepụta obere usoro . Ọgbọ a ọgwụ adịghị yikarị ịkpata nsonaazụ.

Otu akụkụ nke ọgwụ ahụ bụ na etolite ọtụtụ metabolites n'oge mgbanwe metabolic, na otu n'ime ha nwere mmetụta dị ukwuu na microcirculation. Ọtụtụ ọmụmụ gosipụtara mbelata ihe ize ndụ nke nsogbu microvascular (retinopathy na nephropathy) na ọgwụgwọ gliclazide.

Kwesịrị ịmara! Ọzọkwa, ekele Glyclazide, ogo angiopathies na-ebelata, ihe oriri nke conjunctiva na-akawanye mma, na akwara vaskụla na-apụ n'anya.

Ọ bụ ya mere e ji depụta ya maka nsogbu ndị ọrịa shuga mellitus (angiopathy, nephropathy na ọdịda akwara na-adịghị ala ala, retinopathy) a na-akọkwa nke a site na ndị ọrịa bufere, ka ha nyefee ọgwụ a.

Ọtụtụ na-ekwusi ike na a ga-ewere mbadamba mgbe nri ụtụtụ gasịrị, nke nwere carbohydrates zuru oke, agụụ maka ụbọchị adịghị anabata. Ma ọ bụghị ya, megide nri dị obere kalori na oke mgbalị anụ ahụ, mmepe nke hypoglycemia ga-ekwe omume.

Site na nrụgide anụ ahụ, ọ dị mkpa ịgbanwe dose nke ọgwụ. Mgbe ha drinkingụsịrị mmanya, ụfọdụ ụfọdụ nwekwara ọnọdụ nke ịba ụba.

Ndị okenye na-elebara ọgwụ hypoglycemic anya karịsịa, ebe ọ bụ na ihe egwu ha nwere ịba ụba hypoglycemia mụbara. Na njikọ a, ọ kaara ha mma iji ọgwụ ndị na-eme obere oge (gliclazide mgbe niile).

Ndị ọrịa na-achọpụta na nyocha ha banyere ịdị mma nke iji mbadamba ihe eji emegharị emezi: ha na-eme nwayọ na nha, yabụ a na-eji ya otu ugboro n'ụbọchị.Na mgbakwunye, ogo ya dị irè ji okpukpu abụọ dị ala karịa ọgwụ gliclazide ot.

Enwere akụkọ na mgbe ọtụtụ afọ (site na 3 ruo 5 site na mmalite nke oriri), nguzobe malitere - mbelata ma ọ bụ enweghị ọrụ nke ọgwụ ahụ. N'ọnọdụ ndị dị otú ahụ, dọkịta ahụ họọrọ njikọ nke ndị ọzọ hypoglycemic na-elekọta mmadụ.

Dị Mkpa! Mgbe ị na-eji Glyclazide, dị ka ọgwụ ọ bụla ọzọ, ị ga-agakwuru dọkịta gị.

Dịka onye enyemaka ọzọ maka ndị ọrịa mamịrị nke ụdị nke abụọ, yana nri nri kwesịrị ya, ọ na-arụ ọrụ zuru oke. Enwere m mmetụta dị mma ma dị mma karịa, Enwere m mmasị na ọnụahịa na enweghị nsonaazụ dị iche iche, ezigbo nsonaazụ.

Ọ dị mma, shuga anaghị ebelata. A Iụrụ m iko 30, shuga agbadaghị, kama mụbara. Amalitere m ị drinkụ nkeji iri isii. obi bidoro bidoro, mgbali ebilite. Eleghị anya enwere ọgwụ na-agwụ ike. Na ndị ọzọ adịghị. Yabụ na ịzụtara ọgwụ ndị ọzọ n’onwe gị.

Mkparịta ụka ọgwụ ọjọọ

Site na iji Gliclazide MV jikọtara ọnụ na ọgwụ ụfọdụ, mmetụta ndị na-adịghị mma nwere ike ime:

Ihe ndi Pyrazolone, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): ike nke ike hypoglycemic nke glyclazide,
Ndị na - eme nhọrọ beta-ahọrọ: enwere ike ịba ụba hypoglycemia, ịba ụba ọsụsọ na ịma jijiji nke tachycardia na ịma jijiji nke njirimara hypoglycemia,
Gliclazide na acarbose: uto hypoglycemic mmetụta,
Cimetidine: ịba ụba ịba ụba nke gliclazide plasma (hypoglycemia siri ike nwere ike ịmalite, gosipụtara n'ụdị nkụda mmụọ nke sistemụ akwara na ụbụrụ na-enweghị isi),
Glucocorticosteroids (gụnyere ụdị usoro onodu ogwu), diuretics, barbiturates, estrogens, progestin, ọgwụ estrogen-progestogen jikọtara ọnụ, diphenin, rifampicin: mbelata mmetụta hypoglycemic nke glycazide.

Ihe analogues nke Gliclazide MV bụ: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeton MV, Diabefarm MV, Diabinax, Diabetalong.

Nyocha na Gliclazide MV

Gliclazide MV bụ nke sitere n'ụkpụrụ nke sulfonylurea nke ọgbọ nke abụọ ma nwee mmetụta siri ike nke hypoglycemic edinam, nke kọwara site na ịdị elu dị elu maka ndị na-anata β-cell (oge 2-5 dị elu karịa n'ọgbọ gara aga nke ọgwụ). Ngwongwo ndị a na-enye gị ohere iji mmetuta ọgwụgwọ dị ntakịrị ma belata mmeghachi omume na-adịghị mma.

Dabere na nyocha, a na-eji MV Gliclazide mee ihe maka nsogbu nke ọrịa shuga mellitus (retinopathy, nephropathy na ọdịda akwara na-adịghị ala ala, angiopathy). Nke a bụ akụkọ sitere n’aka ndị ọrịa ebugharị ịnata ọgwụ a. Nke a bụ n'ihi eziokwu ahụ bụ na otu n'ime glycazide metabolites na-emetụta microcirculation nke ukwuu, na-ebelata ogo angiopathy na ihe ize ndụ nke ịmalite nsogbu microvascular (nephropathy na retinopathy). N'otu oge ahụ, ọbara ọgbụgba n'ime conjunctiva na-emekwa kawanye mma na akwara vaskụla na-apụ n'anya.

Ọtụtụ ndị ọkachamara na-ekwusi ike na n'oge ọgwụgwọ Gliclazide MV, ọ dị mkpa iji zere agụụ ma nye nri maka nri nwere carbohydrates. Ma ọ bụghị ya, megide ụdị nri nwere kalori na oke mgbatị ahụ, onye ọrịa ahụ nwere ike ịmalite hypoglycemia. Site na nrụgide anụ ahụ, a chọrọ ndozi dose. N'ime ụfọdụ ndị ọrịa, mgbe ha drinkingụsịrị mmanya mgbe a na-eji Gliclazide MV, a chọpụtara ihe mgbaàmà hypoglycemia.

A naghị akwado Gliclazide MV maka ndị ọrịa merela agadi nwere ike ịmalite hypoglycemia, yabụ, na nke a, ọ bara uru iji ọgwụ na-eme mkpụmkpụ.

Ndị ọrịa na-ahụta ịdị mma nke iji gliclazide n'ụdị nke mbadamba ntọhapụ gbanwere: ha na-eme ihe nwayọ karịa, akụkụ ahụ na-arụ ọrụ na-ekesa n'etiti akụkụ ahụ niile. N'ihi nke a, enwere ike ị theụ ọgwụ ahụ otu oge kwa ụbọchị, yana usoro ọgwụgwọ ya bụ ugboro 2 erughị nke gliclazide ọkọlọtọ. Enwekwara akụkọ na site na usoro ọgwụgwọ ogologo oge (afọ 3-5 site na mmalite nke nchịkwa), ụfọdụ ndị ọrịa zụlite nguzogide, nke chọrọ nchịkwa nke ọgwụ shuga ndị ọzọ.

Mpempe usoro onunu ogwu

30 mg na 60 mg mbadamba mbugharị ndenye

Otu mbadamba ihe nwere:

ike ihe - gliclazide 30.0 mg ma ọ bụ 60.0 mg,

ndị na-ebu ụzọ: silikon dioxide anhydrous colloidal, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Mbadamba ụcha dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha na agba, na-enwe ọdịdị cylindrical na bevel (maka usoro nke 30 mg).

Mbadamba dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha na agba, na-enwe ọdịdị cylindrical, facet na notch (maka usoro 60 mg).

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-etinye gliclazide kpamkpam site na eriri afọ. Iri nri anaghị emetụta ogo nke mmịpụta. Nnukwu gliclazide na plasma na-abawanye nwayọ n'oge awa isii mbụ mgbe ọ jesịrị nchịkwa wee rute ala dị larịị nke dị site na 6 ruo awa nke iri na abụọ. Ọdịiche nke abụọ na-adị obere. Mmekọrịta dị n'etiti dose ruo 120 mg na plasma concentration curve of the ọgwụ bụ ịdabere na oge ahịrị. Ihe dị ka 95% nke ọgwụ ahụ na-egbochi protein ndị dị na plasma.

Gliclazide bụ metabolized n'ime akụrụ ma na-abụkarị ya na mmamịrị. A na - emegharị anụ ahụ ọkachasị site na akụrụ n'ụdị metabolites, ihe na-erughị 1% dịpụrụ adịpụ na mmamịrị ya. Ọ dịghị metabolites nọ n'ọrụ na plasma.

Ọkara ndụ (T1 / 2) nke gliclazide a awa 16 (awa 12 ruo 20).

N'ime ndị agadi, enweghị mgbanwe dị ukwuu na pọọmọnokinetic ọgwụ.

Otu ọgwụ kwa ụbọchị nke 60 mg na-enye nsonaazụ dị mma nke gliclazide na plasma maka ihe karịrị awa 24.

Mlọ ọgwụ

Gliclazide MV bụ ọgwụ nke hypoglycemic nke sitere na otu nke usoro II nke usoro sulfonylurea, nke dị iche na ọgwụ ndị yiri ya site na ọnụnọ nke heterocyclic nke N-nwere nwere njikọ njikọ endocyclic.

Gliclazide MB na -ebelata ọkwa nke glucose n'ọbara, na-akpali nzuzo nke insulin site na mkpụrụ ndụ nke agwaetiti nke Langerhans. Mgbe afọ 2 gasịrị ọgwụgwọ, ọtụtụ ndị ọrịa ka nwere mmụba na ọkwa insprandial insulin na zoro ezo nke C-peptides.

Na ụdị ọrịa mellitus nke 2, ọgwụ a na-eweghachi mmalite nke insulin na-emeghachi omume na nzaghachi glucose ma na-eme ka akụkụ nke abụọ nke insulin ahụ dịkwuo elu. A na-ahụta mmụba dị ukwuu na mmiri insulin na nzaghachi mkpali n'ihi nri nri na nchịkwa glucose.

Gliclazide MV nwere mmetụta na microcirculation. Ọ na - ebelata ihe ọghọm nke thrombosis nke obere ọbara, na - emetụta usoro abụọ nwere ike itinye aka na mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na - eme ka platelet (beta-thromboglobulin, thromboxane B2), yana mweghachi nke ọrụ fibrinolytic vaskụla endothelium na ụba ọrụ nke plasminogen anụ ahụ na-eme ihe.

Usoro onunu ogwu na nhazi

Maka nchịkwa ọnụ. Ezubere ọgwụ a maka ọgwụgwọ ndị okenye.

Thebọchị nke MV Glyclazide kwa ụbọchị nwere ike ịdị iche site na 30 mg ruo 120 mg. A na-atụ aro ị takeụ otu ugboro n'ụbọchị mgbe nri ụtụtụ, loda mbadamba ihe niile (na-enweghị nri).

Ọ bụrụ n’ikpere ị takingụ ọgwụ ahụ, ịnweghị ike ịba ụba dose ahụ n’echi ya.

Dị ka ọ dị na ọgwụ hypoglycemic ndị ọzọ, a ga-ahọrọ dose nke ọgwụ a n'ọnọdụ ọ bụla n'otu n'otu, dabere na mmeghachi omume metabolic nke onye ọrịa.

Usoro akwadoro ịmalite bụ 30 mg kwa ụbọchị.

N'ihe banyere ịchịkwa ọkwa nke glucose ọbara dị mma, enwere ike iji ọgwụ a dịka ọgwụgwọ mmezi.

Ọ bụrụ na enweghị nchịkwa zuru oke nke ọkwa glucose, enwere ike ịbawanye dose ahụ ruo 60 mg, 90 mg ma ọ bụ 120 mg kwa ụbọchị. Ọdịiche dị n’etiti mmụba dị n’etiti ọgwụ ahụ kwesịrị ịbụ opekata mpe ọnwa 1, ọ gwụla ma ọkwa ọbara glucose adịchaghị agbasịa izu abụọ. N'ụdị ndị ahụ, enwere ike ịbawanye dose ahụ ugbua izu abụọ mgbe ịmalite ọgwụgwọ.

Oke kachasị atụ aro kwa ụbọchị bụ 120 mg.

Na-agbanwe site na ọgwụ hypoglycemic ọzọ na MV Gliclazide

Na ntughari, usoro ogwu na ọkara ndụ nke ọgwụ ịchọrọ aga-atụle. Oge ntụgharị adịghị achọkarị. Ekwesịrị ịmalite 30 glyclazide MV na 30 mg, na-esote mmezi dabere na mmeghachi omume metabolic.

Mgbe ị na-agbanwe site na ọgwụ ọgwụ ndị ọzọ nke otu sulfonylurea na ndụ ogologo ndụ, iji zere mmụba nke ọgwụ abụọ ahụ, enwere ike ịchọrọ oge ọgwụ na-adịghị ọtụtụ ụbọchị. N'ụdị ndị a, ntụgharị aka na mbadamba nkume nke Glyclazide MV kwesịrị ịmalite site na usoro ọgwụgwọ akwadoro nke 30 mg, nke na-esote mmụba nke usoro na-adabere na mmeghachi omume metabolic.

Jiri ya na ọgwụ ndị ọzọ na-egbochi antidiedi

Enwere ike iji Gliclazide MB yana ngwakọta na biguanides, alpha-glucosidase inhibitors ma ọ bụ insulin. N'ime ndị ọrịa na-achịkwaghị ọkwa glucose ọbara zuru oke site na ị Gụ Gliclazide MV, enwere ike ịkọwa ọgwụ insulin n'otu oge n'okpuru nlekọta nke dọkịta.

Okenye (okenye karịrị afọ 65)

Ngwọta ọgwụ a tụrụ aro ka ndị agadi na-emetụta ndị okenye maka afọ 65.

Usoro ọgwụ a na-atụ aro maka akụrụ gbasara akwara siri ike dị nfe ma ọ bụ agafe agafe bụ otu ihe ahụ maka ndị nwere ọrụ ezumike.

Ndị Ọrịa na Nsogbu Dị Ọbara Hypoglycemia

Bụrụ na nri ezughi ezu ma ọ bụ adịghị mma, n'ọrịa ma ọ bụ na-adịghịzi akwụghachi ụgwọ ọrịa endocrine (hypopituitarism, hypothyroidism, ezughi oke nke adrenocorticotropic homonụ), mgbe ịkagbuchara ogologo oge gara aga na / ma ọ bụ ọgwụ corticosteroid dị elu, na ọrịa vaskụla siri ike (ụdị siri ike nke ọrịa obi na-efe efe, nnukwu mmebi nke patroti nke akwara obi. mee ka ọghọm ụbụrụ na-akpata nkwarụ), a na-atụ aro ịkọ ọgwụ ka ọ dịkarịa ala kwa ụbọchị nke 30 mg.

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ na-eme ka mmetụta nke Gliclazide MV dịkwuo (ohere dị elu nke hypoglycemia)

Miconazole (mgbe ejiri ya rụọ ọrụ ma ọ bụ tinye ya na mucosa ọnụ n'ụdị gel): na-eme ka mmetụta hypoglycemic nke MV Gliclazide (hypoglycemia nwere ike tolite ruo hypoglycemic coma).

Akwadoro maka iji:

Phenylbutazone na - akwalite mmetụta hypoglycemic nke ihe njikọ sulfonylurea (na - ewepụ ha na nkwukọrịta na protein plasma na / ma ọ bụ na - eme ka mkpochapu ahụ ghara ịdị).

Ọ ka mma ka ị useụ ọgwụ mgbochi mbu ọzọ.

Mmanya na-eme ka hypoglycemia kwusi, na-egbochi mmeghachi omume na-akwụghachi ụgwọ, nwere ike itinye aka na mmepe nke hypoglycemic coma.

Ọ dị mkpa ịhapụ ị ofụ mmanya na ị medicationsụ ọgwụ, nke gụnyere mmanya na-egbu egbu.

Njikọ ndị chọrọ ịkpachara anya:

Ojiji nke otu ọgwụ ndị a n’otu oge nwere ike ịka njọ hypoglycemic mmetụta nke ọgwụ Gliclazide MV ma n’ọnọdụ ụfọdụ iduga mmalite nke hypoglycemia:

ndị ọzọ antidiabetic (insulins, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-na-agbanwe enzyme inhibitors (captopril, enalapril), antagonists H2 na-anabata ihe, ndị na-egbochi ọgwụ mgbochi monoamine oxidase (MAO I), sulfonamides na ọgwụ mgbochi mbufụt Steroid.

Ọgwụ ndị na-akụda ike Glyclazide MV

Akwadoro maka iji:

A naghị atụ aro iji ihe oriri ike na danazol n'ihi ihe dị ka mmụba nke glucose ọbara. Ọ bụrụ na ọ gaghị ekwe omume ịjụ ojiji nke danazol, kọwaara onye ọrịa ahụ mkpa ọ dị ịchịkwa mkpokọta glucose na ọbara na mmamịrị. Mgbe ufodu, achoro imeghari onodu nke Gliclazide MV n'oge ọgwụgwọ na mgbe danazol.

Njikọ ndị chọrọ ịkpachara anya:

Chlorpromazine na ọnụọgụ dị elu (karịa 100 mg kwa ụbọchị) na-eme ka glucose dị n'ọbara, na -ebelata ihe nzuzo nke insulin.

Glucocorticosteroids (usoro na ngwa mpaghara: intraarticular, anụ ahụ na njikwa azụ) na tetracosactrin na-abawanye glucose ọbara na mmepe nke ketoacidosis nwere ike, n'ihi mbelata nke nnabata nke carbohydrate site na glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (ojiji usoro) na-ebute mmụba nke ọkwa glucose.

Lezienụ anya na mkpa ọ dị ịchekwa glucose ọbara. Ọ bụrụ na ọ dị mkpa, nyefee onye ọrịa ahụ ọgwụ insulin.

Ọ bụrụ n’ịchọrọ iji nchịkọta ndị dị n’elu, ịkwesịrị ịkwụ ụgwọ nlebara anya pụrụ iche n'ịchịkwa ọkwa glucose ọbara. Ọ nwere ike ịdị mkpa ịmegharị ọnụọgụ nke MV Glyclazide ma n'oge ọgwụgwọ njikọta na mgbe ịkwụsị ọgwụ ọzọ.

Nchịkọta aka nke Gliclazide MV nwere ọgwụ anticoagulant (warfarin, wdg) nwere ike ibute mmụba na ọgwụ anticoagulant nke ọgwụ ndị dị otú ahụ. Enwere ike ịchọ ndozi ọgwụ Anticoagulant.

Mpempe akwụkwọ Mpempe akwụkwọ

JLLC “Lekpharm”, Republic of Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / faksị: +375 1774 53 801, e-mail: [email protected]

Adresị nke nzukọ a na-anabata nnabata n'aka ndị na-azụ ahịa maka otu ngwaahịa dị na mpaghara nke Republic of Kazakhstan

Onye nnọchi anya ụlọ ọrụ nke Lekpharm COOO na Republic of Kazakhstan,

050065, Republic nke Kazakhstan, Almaty, district Alm, ul. Kazybek bi, 68/70, akuku nke st. Nauryzbay batyr, tel. 8 (727) -2676670, faksị 8 (727) -2721178

Aha, adres na kọntaktị nkọwa (ekwentị, faksị, e-mail) nke nzukọ a na mpaghara Republic of Kazakhstan na-ahụ maka ịdebanye aha ndebanye nke nchekwa ọgwụ.

Onye nnọchi anya ụlọ ọrụ nke Lekpharm COOO na Republic of Kazakhstan,

050065, Republic nke Kazakhstan, Almaty, district Alm, ul. Kazybek bi, 68/70, akuku nke st. Nauryzbay batyr, tel. 8 (727) -2676670, faksị 8 (727) -2721178,