Ọgwụ Akkuzid: ntuziaka maka ojiji

Ejikọtara ọgwụ na ọgwụ antihypertensive, nke gụnyere ihe abụọ na-arụ ọrụ: quinapril (igbochi ACE) na hydrochlorothiazide (diuretic) na nchịkọta usoro onunu ogwu ato.

Hinapril Ihe eji eme ya angiotensin IInke mere site na mkpali nke adrenal cortex (imeputa) aldosterone), na-emetụta ụda vaskụla ma nwee mmetụta vasoconstrictor. Hinapril mgbochi ACE (anụ ahụ na ikesa) ma belata ọrụ vasopressor na excretion aldosterone. Nkwụsị mmetụta na-adịghị mma angiotensin II ịzụlite renineduga n'ịba ụba ọrụ renin.

Kpebie EGO na - emegide ihe ndabere sitere na mbelata nguzogide akwara umeji na OPSSn'otu oge, mgbanwe mgbanwe ọ gbasara Oku obi, nnomi na ọbara gbasara akụrụngwa ọbara zuru oke ma ọ bụ na - anọghị ya. Hinapril dịtụ ntakịrị belata potassium kpatara site na ime ihe hydrochlorothiazidenke, na-enwe mmetụta ọria dials, na-abawanye ọrụ renin ọbara, na-eme ka ihe nzuzo dịkwuo elu aldosterone, na-abawanye ihe ndị dị n’ime potassium n’ime ọbara ma na-eme ka mpụga ya site na akụrụ. The antihypertensive mmetụta na-etolite n'ime otu awa na-eru a kacha mgbe awa 3, na-aga n'ihu ụbọchị.

Hydrochlorothiazide - na - ezo aka na otu diuretics, na - emetụta ọrụ nke akụrụ, na - eme ka mkpụrụ ndụ sodium, potassium, chlorides, bicarbonate ion na mmiri mgbe ị na -ebelata mpụga calcium. A na-egosipụta mmetụta ahụ ọ na-apụta na mgbe awa 2 gasịrị, nsonaazụ kachasị bụ mgbe awa anọ gasịrị ma oge ya bụ 6-12 awa.

Njikọ nke bekee na-arụ ọrụ (quinapril na hydrochlorothiazide) na-enye ibelata aha akpọpụtara EGOkarịa omume nke ọ bụla n’ime ha n’otu n’otu.

Mlọ ọgwụ

Ihe abuo n’ile anya adighi emetuta ibe ha.

Hinapril - A na-enweta Cmax mgbe awa 2 gachara. Ogo ogo ihe dika 60%. Nnukwu ejikọtara na protein protein. Na imeju, biotransformed ka quinaprilataịbụ onye na - egbochi ike ACE. Abanyela n’ime ya BBB. Ọ bụpịrị ya site na akụrụ, T1 / 2 - ihe dịka awa 3.

Hydrochlorothiazide - nwere mmetụ nwayọ nwayọ, ogo nke mmịpụta nke 50-80%. A na-enweta Cmax n'ime awa 1-3. Abanyela n’ime ya BBB. Anụ ahụ adịghị ya oke, anapụrụ ya site na akụrụ ya. T1 / 2 - site na 4 ruo 15 awa.

Ihe ngbanwe

• Nnukwu uche dị na ọgwụ ahụ,
• na anamnesis - angioedema mgbe ọgwụgwọ na inhibitors ACE,
• Ọrịa Addison,
• ngbaka,
• afọ ruo afọ 18
• ọrịa shuga mellitus,
• tụụrụ ime na ara.
• akpọ gbasara akwaraimeju imeju
• esighi ike lactases.

Akkuzid, ntuziaka maka ojiji (usoro na usoro onunu ogwu)

A na-ewere mbadamba Akkuzit 1 otu oge kwa ụbọchị n'echeghị nri oriri. Usoro akwadoro kwa ụbọchị a na-atụ aro maka ndị ọrịa na-anabataghị ọrịa diuretic bụ 10 mg + 12.5 mg (otu mbadamba nke Accuzit 10), ọ bụrụ na ọ dị mkpa, a na-abawanye ọgwụ mbụ kwa ụbọchị ruo ogo kachasị mma kwa ụbọchị nke 20 mg + 25 mg (otu mbadamba nke Accuzit 20). Dịka iwu, nsonaazụ ahụ na-apụta mgbe ị na-a theụ ọgwụ ahụ na usoro onunu ogwu si na (10 +12.5 ruo 20 +12.5) mg kwa ụbọchị. Ọrịa anaghị eme mgbanwe ọ bụla maka ndị okenye. Na ọnụnọ nwere oke akụrụ gbasara akwara na ndị ọrịa, ekwesighi iji ọgwụ a dịka ọgwụgwọ mbụ.

Dodoụbiga ya ókè

Isi ihe ngosipụta nke ịdoụ ọgwụ oke ogologo oge na iji ọgwụ gafere oke ọgwụgwọ bụ ọgwụ na-aga n'ihu. EGO, ọgba aghara na mmiri na nguzozi electrolytic, gosipụtara hypochloremia, hyponatremia, hypokalemia.

Mmekorita

Site na nhazi nke imekọ ihe ọnụ nke Accuzide yana ọgwụ nje nke otu ahụ tetracycline usoro mmiri tetracycline belatara otu ụzọ n’ụzọ atọ. A naghị atụ aro ya ka ịkwado nkwakọ lithium yana diuretics, ebe ọ bụ na ọrịa diuretics na-ebelata nhichapu lithium na ihe ize ndụ nke ịxụbiga mmanya ókè. Mgbe ị na-ewere Accid ethanolnyocha opioid, barbiturates na Ọgwụ c maka ịkụnwụ ọnụnọ ọrịa na-ebute ọrịa orthostatic hypotension. Site na nke imekotaotu aka nke Accuzide ya insulin ma obu ọgwụ hypoglycemic ndozi nke usoro hypoglycemic dị mkpa. Hydrochlorothiazide dị ka akụkụ nke Akkuzid na-akwalite ọrụ nke ọgwụ antihypertensive ejiri otu oge ya.

Site na nhazi nke corticosteroid ọgwụ na Accuid, mmụba na ọnwụ nke potassium na electrolytes ndị ọzọ ga-ekwe omume. N'ikuku Ndị NSAID na-akpata ike ọgwụgwụ nke antihypertensive, diuretic na natriuretic edinam nke diuretics. Site na nhazi oge a nke akwara izu ike na Akkuzid, enwere ike ịkwalite ọrụ ha.

Usoro onunu ogwu na nhazi

Ọgwụ nke Accuid na-abụkarị otu mbadamba (10 mg / 12.5 mg) kwa ụbọchị. Dọkịta gị nwere ike ịbawanye ọgwụ a na mbadamba abụọ kwa ụbọchị, enwere ike ibikọ ọnụ otu ugboro n'ụbọchị ma ọ bụ iche - otu mbadamba n'ụtụtụ, otu na mgbede.

Were Accuzide oge niile dika dọkịta gị gwara gị. Ejila mbadamba mbadamba ihe dọkịta gị tụrụ aro ya.

Gbalịa ịillsụ ọgwụ n'otu oge nke ụbọchị kwa ụbọchị, n'agbanyeghị nri.

• Ọ bụrụ na echefuru ị aụ ọgwụ ahụ, were ya ozugbo, ka ị na-echeta, na-echeghị oge ọzọ ị takeụrụ ọgwụ ahụ. Ejila ogwu ogwu abụọ.
• Ọ bụrụ na ihie ụzọ n ’ihi nnukwu Akkuzid mbadamba, gwa dọkịta gị ozugbo Ọ bụrụ na ịnweghị ike ime nke a, kpọtụrụ ngalaba mberede na ụlọ ọgwụ kacha nso. Soro na ngwugwu ọgwụ ahụ, ọbụlagodi na enweghị mbadamba apụtaghị ka ndị ọrụ ụlọ ọgwụ nwee ike ịchọpụta ọgwụ ị .ụrụ n'ụzọ dị mfe.
• A naghị akwadoro Accid maka ụmụaka. Agụghị ọgwụ ahụ n’ime ndị ọrịa na-erubeghị afọ 18.

Mmetụta akụkụ

Dika ogwu ndi ozo eji aru oria gi, Accuzide nwere ike inwe oge ufodu na adighi nma. Ọ bụrụ n’ịzụlite akara ndị a, ị ga-agakwuru dọkịta gị.

• Nọgide na-akọrọ ụkwara.
• Na ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, afọ ntachi, afọ mgbu, flatulence, dyspepsia, ma ọ bụ mgbu afọ.
• Isi ọwụwa, nkụda mmụọ, iwepụ ụra, ehighị ụra nke ọma, ụra, ike ọgwụgwụ, enweghị mmasị ma ọ bụ ike ọgwụgwụ, ma ọ bụ mmetụta mbụ.
• Mgbu na azụ, obi, akwara, ma ọ bụ nkwonkwo (gout).
• Akpukpo aru, itching ma obu hypersensitivity to light, skin skin.
• Ọrịa akụrụ (site n'oge ruo n'oge, ọ bụrụ na dọkịta gị enyocha mmepe nke ọrịa akụrụ, dọkịta gị nwere ike ịkọpụta nyocha nke mmụba).

Mmetụta dị n'akụkụ nke na - adịghị ahụkarị gụnyere: ịchabiga ihe ókè, akpịrị ọnụ / akpịrị, ntutu isi, enweghi ike, ọrịa urinary (akpịrị akọrọ nwere ike ibute ọrịa), ịmịcha mkpụrụ obi na ogwe aka ma ọ bụ ụkwụ, ọnya na-akụ afọ mmiri, nkụda mmụọ. , ọgba aghara, mgbakasị ahụ, tinnitus, ọhụhụ ụzọ, uto isi, edema (oke).

Ọ bụrụ n’ịzụlite akara ndị a, ị ga-agakwuru dọkịta gị.

Ọ bụrụ na ị zụlitela ọgụ nke nkụda mmụọ, mgbe ahụ ị kwesịrị ịhapụ ịkwọ ụgbọala na usoro ndị ọzọ.

Accuid nwere ike ibute ụfọdụ mgbanwe na foto ọbara. Yabụ, onye na-ahụ maka ahụike gị nwere ike ikwenye nnwale ọbara iji nyochaa nke a. Ọ bụrụ n ’ọnya, nwee mmụọ nke ike ọgwụgwụ, ọ bụrụ na ị nwere ọrịa shuga, ị wee chọpụta mmụba nke glucose ọbara, gwazie dọkịta gị ma ọ bụrụ na ọ dị mkpa, ị ga-enyocha ọbara.

Mmetụta ndị na - esote adịghị obere, mana ha siri ike, yabụ ọ bụrụ na ịnwere nke ọ bụla, gwa dọkịta gị ozugbo.

• Ọkpụkpụ Angioneurotic (ọzịza nke ihu, ire, ọnya - nwere ike ibute iku ume). N'otu oge, angioneurotic edema nke afọ na eriri afọ (eriri afọ angioedema - akụkụ nke eriri afọ) nwere ike ịmalite n’onweghị. N'ụdị dị otú a, ị ga-enwe ahụike; Ndị a dị obere, mana mmeghachi omume dị oke njọ, ma ọ bụrụ na i mebela ha, ị kwesịrị ịkpọ ụgbọ ihe mberede.
• Eeeeụja n’ime obi, mgbu obi, aka palpis, mkpọtụ ma ọ bụ ume iku ume.
• Ọrịa akpịrị ma ọ bụ ọnya n'ọnụ. Ọ bụrụ na ị nwere nsogbu akụrụ ma ọ bụ na ị na-enwe ọrịa anụ ahụ na - agbasa, ị nwere ike ịmalite neutropenia / agranulocytosis (mkpụrụ ndụ ọbara ezughị ezu), nke nwere ike ibute ọrịa, akpịrị mgbu, ma ọ bụ ahụ ọkụ. Y’oburu n’iburu oria n’azu aru, dọkịta gi nwere ike nye gi nnwale ọbara iji nyochaa onodu a.
• Ainda mba, karịsịa mgbe ị na-eguzo ọtọ, nwere ike ịpụta na ọbara mgbali gị dị obere. Ọnọdụ a ga - ebilite mgbe ị na - a diụ ọgwụ (diuretics), ọgwụ ndị ọzọ na - belata ọbara mgbali elu, na mmanya na - egbu gị mgbe ị na - egbu oke mmiri ma ọ bụ na - enwe usoro ọgwụgwọ mgbe ị na - ewere ya na Accuzide. Ọ bụrụ n ’anya gị agbajila ma ọ bụ ọ dị gị ka ị na-agafe, were ọnọdụ kwụ ọtọ ma dina n’ebe ahụ ruo mgbe mmetụta ahụ gafere.
• Nsogbu ndị ọzọ na-adịghị ahụkebe ma dị oke njọ gụnyere ịchapu ọnya ọnya na anụ ahụ (jaundice), oke mgbu na afọ na azụ (pancreatitis), adịghị ike na elu na ala ala, ma ọ bụ na-ekwu okwu isi ike (ikekwe ọnya afọ).

Ime

Iji ọgwụ ọjọọ eme ihe Kwenye contraindicated n'oge ime, ụmụ nwanyị na-eme atụmatụ ime, yana ụmụ nwanyị nke afọ omumu na-ejighi ụzọ ịtụkwasị obi nke igbochi.
Womenmụ nwanyị ndị toro afọ na-ewere Accuside® kwesịrị iji ụzọ ịtụkwasị obi na-egbochi afọ ime.
Ọ bụrụ na ime dị n’oge ọgwụgwọ na Accuzide, ekwesịrị ịkwụsị ọgwụ a ozugbo enwere ike.
Nhọpụta nke ndị na - egbochi ACE n'oge ịtụrụ ime yana nnukwu ohere nke ibute ọrịa nke akwara ozi na akwara ozi nwa ebu n’afọ. Na mgbakwunye, megide ndabere nke iji ACE inhibitors n'oge ịtụrụ ime, ikpe gbasara oligohydramnios, ịmụ nwa, ọmụmụ ụmụ nwere ọrịa hypotension, ọrụ ezigharị mkpamkpa, gụnyere nnukwu akwara kpụrụ akpụ, hypoplasia nke ọkpụkpụ nke okpokoro isi ahụ, nkwekọrịta nke aka na ụkwụ, craniofacial anomalies, pulmonary hypoplasia, hypoplasia hypoplasia kọwara. , oghe ductus arteriosus, yana okwu gbasara ọnwụ nwa ebu n’afọ na ụmụ amụrụ ọhụrụ. Ọtụtụ mgbe, a na-achọpụta oligohydramnios mgbe nwa ebu n'afọ mebiri emebi nke ukwuu.
A ga-enyocha ụmụ amụrụ ọhụrụ nke na-ekpughere intrauterine intrauterine iji chọpụta mkpụrụ ndụ akwara, oliguria na hyperkalemia. Mgbe oliguria pụtara, ekwesịrị idobe ọbara mgbali elu na mmanu isi akụrụ.
Thiazides na-agafe oghere dị n'ime oghere ọbara ma a na-ahụ ya n'ọbara nke eriri nwa. Mmetụta ndị na - abụghị teratogenic nke thiazides gụnyere jaundice na thrombocytopenia nke nwa ebu n’afọ na / ma ọ bụ nwa amụrụ ọhụrụ, enwere ike ikwe omume nke omume ọjọọ ndị ọzọ hụrụ na ndị okenye.
Ndị na - egbochi ACE, gụnyere hinapril, ruo nwa obere ka ọ banye n'ime mmiri ara. A na-ahụkarị ihe ndị Thiazide na mmiri ara. Nyere ohere enwere ike ibute mmeghachi omume ojoo n’ime ụmụ amụrụ ọhụrụ, ekwesighi iji Akkuzid n’oge a na-enye nwata ara, ọ bụrụ na ọ dị mkpa, a ga-akwụsị ịfeụ ara.

Mpempe mwepụta

taabụ. mkpuchi ihe nkiri, 10 mg + 12.5 mg: 30 PC.
taabụ. mkpuchi ihe nkiri, 20 mg + 12.5 mg: 30 PC.
taabụ. mkpuchi ihe nkiri, 20 mg + 25 mg: 30 pcs.

1 mbadambaKwenye nwere: quinapril hydrochloride 10.832 mg, nke kwekọrọ na ọdịnaya nke quinapril 10 mg
hydrochlorothiazide 12.5 mg.
Ndị na-ahụ maka ya: lactose monohydrate - 32.348 mg, magnesium carbonate - 35.32 mg, povidone K25 - 4 mg, crospovidone - 4 mg, magnesium stearate - 1 mg.
Ihe mejupụtara nke uwe ihe nkiri: opadray pink OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, iron oxide dye edo edo, iron dye oxide red) - 3 mg, herbal wax - 0.05 mg.
Akkuzid mbadamba 1 nwere: quinapril hydrochloride 21.664 mg, nke kwekọrọ na ọdịnaya nke quinapril 20 mg.
hydrochlorothiazide 12.5 mg.
Ndị na-ahụ maka ihe: lactose monohydrate - 77.196 mg, magnesium carbon - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Ihe mejupụtara nke uwe ihe nkiri: opadray pink OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, iron oxide dye edo edo, iron dye oxide red) - 6 mg, herbal wax - 0.1 mg.
1 mbadambaKwenye nwere: quinapril hydrochloride 21.664 mg, nke kwekọrọ na ọdịnaya nke quinapril 20 mg.
hydrochlorothiazide 25 mg
Ndị na-ahụ maka ya: lactose monohydrate - 64.696 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Ihe mejupụtara nke uwe ihe nkiri: opadray pink OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, iron oxide dye edo edo, iron dye oxide red) - 6 mg, herbal wax - 0.1 mg.

Usoro onunu ogwu na nhazi

Akkuzid bu n'uche eji ya eme ihe. Otutu iri - otu oge kwa ubochi, n’agbanyeghi nri oriri.

Edebere ndị ọrịa na-adịghị agwọ ọrịa diuretic Accuzid 12.5 mg + 10 mg mbadamba, 1 pc ọ bụla. kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume ịdebe Asị 25 mg + 20 mg, 1 pc. kwa ụbọchị.

A na-ahụkarị njikwa ọbara mgbali dị mma site na iji usoro ọgwụ kwa ụbọchị na oke sitere na 12.5 mg + 10 mg ruo 12.5 mg + 20 mg.

Usoro usoro usoro ọgwụgwọ maka ndị ọrịa ọrịa pụrụ iche:

• arụ ọrụ ezigharị dị nro nke ịdị nro dị nro (mwepụ nke kerete erughị 60 ml / min): Accuzide 12.5 mg + 10 mg - 1 pc. kwa ụbọchị
• arụrụ ọrụ na-arụ ọrụ nke obere mkpụkọ (ike idozi 60-30 ml / min.): ọgwụ mbụ nke quinapril bụ 5 mg na ntinye ọzọ, a naghị enye ndị ọrịa nke otu a ọgwụ Accuzide dị ka usoro ọgwụgwọ mbụ,
• ịka nká: Accuzide 12.5 mg + 10 mg - 1 pc. kwa ụbọchị, a chọghị ịgbanwe ọgwụ ụfọdụ.

Nsonaazụ

Ihe ojoo nke mere na ihe kariri 1% nke ndị ọrịa na-anata quinapril na hydrochlorothiazide:

• paradaịs laboratia: hypercreatininemia, hyperazotemia,
• isi: isi ọwụwa, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, ọgbụgba nri, akwara mgbu, obi mgbu, mgbu afọ, azụ mgbu, ọnya nje, ọria akwara, sinusitis, pharyngitis, elu akụkụ okuku ume na ibute ọrịa, ụkwara na-adịgide adịgide ụkwara. ihe mgbaàmà nke vasodilation, ike ọgwụgwụ, ọrịa asthenic, ehighị ụra.

Ihe ojoo nke mere na 0,5-1% nke ndị ọrịa na-anata quinapril na hydrochlorothiazide:

• sisitemu hematopoietic: mbelata nke ogo nke leukocytes, platelet, granulocytes, anaemia hemolytic,
• Sistemmuma ụjọ: nkụda mmụọ, iro ụra, oke iwe, ụfụ na akwara ụkwụ,
• sisitemu akwara: palpitations, tachycardia, arrhythmia, angina pectoris, nkụchi obi, infarction myocardial, mbelata ọbara mgbali elu, oke orthostatic hypotension, nkụda mmụọ, ọnya ọgbụgba, ọgbụgba ọbara, nsogbu oke,
• usoro iku ume: sinusitis, ume iku ume,
• sistem nri: ọgbụgba, ọnya afọ, akpịrị akwara nke ọnụ na akpịrị, angioedema, nsia afọ, pancreatitis, ịba ọcha n'anya, ule na-arụ ọrụ imeju, ọbara ọgbụgba site na eriri afọ,
• nfụkasị ahụ: ihe nfụkasị anụ ahụ, urticaria, pruritus, edema nke Quincke, fotoensitivity, Stevens-Johnson syndrome, exfoliative dermatitis, pemphigus, mmeghachi omume anaphylactoid, ịsụsọ oke,
• sistem mọzụlụ na anụ ahụ nwere njikọ: arthralgia,
• sisitemu mkpụrụ ndụ: urinary tract na-efe efe, akụrụ gbasara akwara, nnukwu nsogbu gbasara akụrụ, ọdịda nke ike,
• ahu nke anya:
• mmeghachi omume ndị ọzọ: hyperkalemia, alopecia, yana nkwadebe ọla edo: ọgbụgbọ, ọgbụgbọ, hyperemia nke ọdịdị ihu, mbelata ọbara mgbali elu, ọrịa ọrịa-flu.

Ihe omuma ndi a bu akparamagwa nke ihe kariri akkuzid: nnuku na nnabata mmiri-nnu, mbelata ọbara mgbali elu, mbelata nke ihe di n’ime ya. Na mgbakwunye na glycosides cardiac, ohere nke arrhythmias na-abawanye.

Ọgwụ overdose: ịkwụsị ọgwụ ahụ, lavage gastric, nchịkwa ọnụ nke adsorbents, nchịkwa intravenous (iv) nke 0.9% sodium chloride ngwọta, nkwado na ọkọlọtọ symptomatic ọgwụgwọ.

Ntụziaka pụrụ iche

Enwere ihe akaebe banyere ikpe nke angioedema nke olu na ihu n'oge ọgwụgwọ ya na ndị mgbochi ACE, gụnyere na 0.1% nke ndị ọrịa na-anata hinapril. N'ihe banyere angioedema nke ihu, ire, olu na-ekwu okwu, anya ma ọ bụ ure na -eme ihe na iku ume, na-elo nri, Akkuzid kwesịrị ịkagbu ozugbo. Ekwesịrị ịnye onye ọrịa ahụ ọgwụ zuru oke ma nyochaa ọnọdụ ya ruo mgbe mgbaàmà nke edema ga-akwụsị, enwere ike iji ọgwụ antihistamines belata ha. Site na angioedema metụtara akwara, enwere ike ịnwe nsonaazụ. Y’oburu, n’ihi osisa n’ofe olu, ire ma obu ekpughere n’enweghi ike, o bu ihe kwesiri igha bu igba ogwu ihe mberede, g’emechi ochichi nke uzo nke adrenaline na 1: 1000 (0.3-0.5 ml).

N'ime ndị ọrịa nwetagoro ọrịa angioedema na-ejikọghị na ịnara Accuzide na ACE inhibitors, ohere nke mmepe ya na-abawanye na iji ọgwụ ndị otu a.

Accuzide nwere ike ime ka mbelata ọbara mgbali ugboro ugboro, agbanyeghị, ọ na-abụkarị karịa monotherapy ya na ihe abụọ dị n'ọrụ. Imirikiti hypotension na-ejikọ ya na ọbara mgbali elu na-enweghị mgbagha, mana ọ nwekwara ike ịmalite n’etiti ndị ọrịa nwere BCC belata, dịka ọmụmaatụ, mgbe ọgwụgwọ ọrịa diuretic gasịrị, n’ihi ntakịrị nri nnu ma ọ bụ ịba ọcha n’anya.

N'ihe banyere mgbaàmà hypotension akwara, onye ọrịa ahụ kwesịrị dinara ala. Ọ bụrụ na ọ dị mkpa, a na-eme infusion nke 0.9% sodium chloride solution. Mbelata ọbara mgbali oge adịghị ewepu nlọghachi Akkuzid, agbanyeghị, ọ dị mkpa ịhazigharị dose.

N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala na / na-enweghị ọnya akụrụngwa akụrụngwa, ịnara Accuzide nwere ike ibute mbelata ọbara mgbali elu, yana oliguria na azotemia. N'ọnọdụ ndị a na-adịghị ahụkebe, mmepe nke nnukwu akụrụ oke ọdịda na ọbụna ọnwụ ga-ekwe omume. Ekwesịrị ịhapụ ụdị ndị ọrịa n'okpuru nlekọta ahụike.

N’oge na-adịbeghị anya, ọgwụgwọ Accuzide nwere ike ibutelata mbelata nke granulocytes n’ọbara ruo n’ọkpụkpụ oke na mwepu ụmị ọkpụkpụ, ma a ga-achịkwa ọnụọgụ nke leukocytes n’ọbara.

Ọdịdị ntakịrị nke ihe mgbaàmà nke ọrịa (ahụ ọkụ, ọnya akpịrị) na-egosi mkpa ọ dị ịhụ dọkịta, ebe ha nwere ike igosipụta neutropenia.

Achọpụtaghị Accuzide maka nsogbu akụrụ siri ike (mwepụ nke ihe na-erughị 30 ml / min), ebe ọ bụ na azotemia na nsonaazụ nwere ike ibute site na iji ogologo oge.

N'ime ndị ọrịa nwere nnukwu nkụchi obi, iji ACE inhibitors nwere ike ibute mbelata ọbara mgbali elu, nke nwere ike iduga mbelata oke mmamịrị nke akụrụ wepụtara na / ma ọ bụ na-abawanye ọkwa ọbara nke ngwaahịa metabolic nitrogen nke akụkụ aka ya. Anaghị egbochi akụrụngwa akwara ukwu na / ma ọ bụ ọnwụ.

N'oge ọgwụgwọ Accuside, ọbara ọgbụgba, arụ ọrụ akụrụ, na ọkwa plasma electrolyte kwesịrị inyocha. Ekwesịrị izere ojiji nke quinapril na ndị ọrụ na-emegide usoro renin-angiotensin-aldosterone (RAAS). Nchikota a bu ihe amamihe bu na

N'ime ndị ọrịa nwere ọrụ ịba ọcha n'anya ma ọ bụ ọrịa imeju na-aga n'ihu, a na-eji nlezianya mee ihe Accuzide, ebe ọ bụ na obere mgbanwe na mmiri-electrolyte nwere ike ime ka mmepe nke hepatic coma.

Ihe dị ka 2% ndị ọrịa agwọ ọrịa quinapril nwere hyperkalemia. A naghị atụ aro ka ojiji nke Accuzide na potassium na-eme ka ọnụọgụ dị n'otu.

Ure chloride metụtara ịba Accuzide na-adịkarị nwayọ ma chọọ ọgwụgwọ pụrụ iche naanị n'okwu ndị dịpụrụ adịpụ (dịka ọmụmaatụ, yana ọrịa pathologies nke imeju na / ma ọ bụ akụrụ).

N’oge ihu igwe na - ekpo ọkụ, iwere Accuzide n’ime ndị ọrịa nwere nsogbu oke nwere ike ime ka mbelata nke ahụ dị n’ahụ. Ọnọdụ a chọrọ ọgwụgwọ nnọchi.

Hinapril na -ebepụta mpụta nke kalsel, na-eme ka mmiri ọgwụ magnesium na mmamịrị na-abawanye, nke nwere ike ibute hypomagnesemia.

Quinapril nwere ike iwelie serlesterol seric, uric acid na triglycerides. Ọ na - abụkarị mmetụta ndị a dị nro, mana, n'ọnọdụ ụfọdụ, ha nwere ike ibute mmepe nke gout na ọrịa shuga.

Highụ ọgwụ Accuzide dị elu nwere ike ibute hyperkalemia (ị gafere oke ≥100 mg kwa ụbọchị), na-akụghasị njikwa nke glucose ọbara. N'oge ọgwụgwọ, a na-atụ aro ijikwa ọkwa glucose plasma ma, ọ bụrụ na ọ dị mkpa, dozie ọgwụgwọ hypoglycemic.

Tupu a waa ya ahụ, onye ọrịa ahụ kwesịrị ịdọ dọkịta ahụ aka na ntị na ọ na-ewere Accuzide.

N'oge ọgwụgwọ ọgwụ, mmepe nke ụkwara na-enweghị mkpụrụ na-achọpụta ihe. Ọ na - agafe mgbe ọ kwụsịrị ọgwụ ahụ.

Hydrochlorothiazide nwere ike iduga mmepe nke glaucoma mmechi nnukwu yana myopia nwa oge. Enweghị ọgwụgwọ kwesịrị ekwesị, nnukwu ọgụ nke glaucoma jupụtara n'ọhụụ.

Womenmụ nwanyị nke afọ omumu mgbe ha na-eji Akkuzid aga-echedo ya site na ịtụrụ ime. N'ihe banyere mmalite ya, ịkagbu ọgwụ ahụ ozugbo enwere ike.

N'oge ọgwụgwọ ya na Accuside, ekwesịrị ịkpachara anya mgbe ị na-arụ ụdị ọrụ chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor, gụnyere ịkwọ ụgbọ ala na usoro ndị ọzọ dị mgbagwoju anya, karịsịa na mmalite ọgwụgwọ.

Mkparịta ụka ọgwụ ọjọọ

• diuretics: Mmụba hypotensive nke Akkuzid,
• ethanol, usoro nke barbituric acid, narcotic analgesics: ịba ụba nke mbibi orthostatic,
• glucocorticosteroids (GCS), homonụ nke adrenocorticotropic (ACTH): mfu ụba nke electrolytes, ọkachasị potassium,
• digoxin: ịba ụba nke digoxin ịxụbiga mmanya ókè (gụnyere nsogbu ọgba aghara nke na-egbu egbu),
• ọgwụ hypoglycemic: mmepe nke hyperglycemia, ụba nnabata glucose,
• ọgwụ vasoconstrictor: mbelata mmetụta ha,
• tetracycline na ọgwụ ndị ọzọ na - emekọ magnesium: ibelata nnabata nke ihe ha na - arụ ọrụ,
• ọgwụ lithium nwere: belata mkpụcha mkpata nke lithium, ohere i nwere ibute mmeghachi omume ọjọọ, ịbawanye n'ihe egwu lithium,
• ọgwụ mgbochi ọgwụ ndị ọzọ: na-eme ka ọrụ ha dịkwuo mma, ọkachasị ndị na-egbochi beta na ndị na-egbochi ganglion,
• ọgwụ mgbochi na - abụghị steroidal anti-inflammatory (NSAIDs): na - akụda hypotensive, diuretic, natriuretic edinam nke Accuzide, na-arụ ọrụ ezughị ezu na ndị ọrịa, yana yana BCC na dysfunction renalction belata,
• ọgwụ na-abawanye larịị nke potassium n'ime ọbara: mmụba nke ohere nke ịmalite hyperkalemia,
• ion mgbanwe: panata ikike hydrochlorothiazide,
• ọgwụ mgbochi-gout: ikike ịchịkwa ọnọdụ nke ndị ọrịa nwere gout, mmụba ugboro ugboro nke mmeghachi omume hypersensitivity na ihe mgbochi-gout,
• ọgwụ ọjọọ, ọgwụ ọjọọ, ọgwụ iji belata ọbara mgbali elu: Mmetụta hypotensive nke Accuzide,
• immunosuppressants, cytostatics, allopurinol, procainamide: ohere dị ukwuu nke ịrịa leukopenia,
• cardiac glycosides na ọgwụ ndị ọzọ nwere ike ibute mmepe nke ụdị arrhythmias pirouette: ịba ụba nke hypokalemia, mmụba na-egbu egbu,
• aliskiren: enwere ike mgbochi nke ọrụ RAAS okpukpu abụọ, nke gosipụtara site na mbelata ọbara mgbali elu, mgbanwe na ọrụ mkpo, hyperkalemia,
• mTOR na DPP-4 enzyme inhibitors: ohere dịwanye elu nke etolite Quincke edema.