Etu esi eji ọgwụ Rosinsulin M mee ihe?
Nkwụsị nke nchịkwa s / c nke agba ọcha, mgbe ọ na-eguzo ọtọ, nkwụchi ahụ na-edozi. Mmiri nke dị n’elu mmiri ahụ na-acha uhie uhie, enweghị agba ma ọ bụ ihe fọrọ nke nta ka enweghị agba. A na - eji nwayọ nwayọ were weghachite ihe omume.
1 ml | |
insulin biphasic usoro ọmụmụ mmadụ | 100 IU |
Ndị pụrụ iche: protamine sulfate 0.12-0.20 mg, sodium hydrogen phosphate dihydrate 0.26 mg, crystalline phenol 0.65 mg, metacresol 1.5 mg, glycerol (glycerin) 16 mg, mmiri d / na ruo 1 ml.
5 ml - karama (5) - ngwugwu na-acha uhie uhie (aluminom / PVC) (1) - ngwugwu nke kaadiboodu.
10 ml - karama (1) - ngwugwu nke kaadiboodu.
3 ml - katọn (5) - ngwungwu ngwongpo blir (aluminom / PVC) (1) - ngwugwu nke kaadiboodu.
Omume ọgwụ
Ngwakọta Rosinsulin M 30/70 bụ nhazi insulin na-arụ ọrụ dị ala. Ihe mejupụtara ọgwụ ahụ gụnyere insulin soluble (30%) na insulin-isophan (70%). Insulin na-anabata ya na otu onye nnabata nke akpụkpọ ahụ dị na cytoplasmic nke dị na sel na –emepụta ụlọ ọrụ insulin-receptor. Site na mmezi nke biosynthesis cAMP (na sel na abụba) ma ọ bụ, na-abanye n'ime sel (akwara), insulin-receptor complex na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthase, wdg). A na-eme ka mbelata ọbara glucose ọbara site n’ịbawanye na ebufe ọbara n’ime akwara, ịba ụba na nnabata nke anụ ahụ, mkpali nke lipogenesis, glycogenogenesis, njikọ protein, mbelata ọnụego glucose mepụtara site na imeju, wdg.
Oge ihe nke insulin na-eme bụ n'ihi nzere, nke dabere n'ọtụtụ ihe (dịka ọmụmaatụ, na usoro, usoro na ebe nchịkwa). Ya mere, profaịlụ nke insulin emereme nọ n'okpuru mgbanwe dị iche iche, na ndị dị iche iche na otu onye.
Na nkezi, mgbe nchịkwa sc, Rosinsulin M mix 30/70 amalite ime ihe na awa 0,5, mmetụta kachasị na-etolite na nha site na awa anọ ruo na awa iri na abụọ, oge ọrụ ahụ ruru awa 24.
Ihe ngosiputa nke ogwu Rosinsulin M mix 30/70
- oria oria 1 n’ime ndi okenye,
- ụdị 2 ọrịa shuga mellitus: ogbo nke iguzogide ndị ọrịa hypoglycemic nke ọnụ, nguzogide ele mmadụ anya na ọgwụ ndị a (n'oge ọgwụgwọ njikọta), ọrịa intercurrent.
Koodu ICD-10 | Ngosipụta |
E10 | Ọrịa shuga 1dị 1 |
E11 | Ọrịa shuga 2dị 2 |
Usoro usoro onunu ogwu
Ngwakọta Rosinsulin M 30/70 bụ maka nchịkwa sc. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu, dabere n’ịchịkọta glucose dị n’ọbara. Na nkezi, kwa ụbọchị ọgwụ a sitere na 0,5 ruo 1 IU / kg body body, dabere na njirimara onye ọrịa na ntinye glucose n'ọbara.
Okpomoku nke mmanu insulin kwesiri ino na okpomoku. Tupu ojiji, nkwanye ahụ ji nwayọ gwakọta ruo mgbe edo edo. Ngwakọta Rosinsulin M 30/70 bụ nke a na-etinyekarị n'apata ụkwụ. Enwere ike ịmekwa ya na mgbidi nke oghere ihu, ogwe ma ọ bụ ubu na ịkọwapụta akwara ahụ.
Okwesiri igbanwe ebe ogwu ngbanyere na mpaghara anatomical iji gbochie mmepe nke lipodystrophy.
Mmetụta akụkụ
N'ihi mmetụta nke metabolism metabolism: ọnọdụ hypoglycemic (pallor nke anụ ahụ, ịba ụba ọsụsọ, palpitations, ịma jijiji, agụụ, oke iwe, paresthesia n'ọnụ, isi ọwụwa). Nnukwu hypoglycemia siri ike nwere ike iduga mmepe nke hypoglycemic coma.
Mmeghachi omume nfụkasị ahụ: ọ na - adịkarịghị - ọnya anụ ahụ, ọnya Quincke, nke a na - adịghị ahụkebe - ujo anacticlactic.
Mmeghachi omume mpaghara: hyperemia, ọria na itching na ntụtụ ahụ, yana iji ogologo oge - lipodystrophy na saịtị ahụ.
Ndị ọzọ: edema, njehie na - ebugharị ebumnuche (ọ na - abụkarị mmalite nke ọgwụgwọ).
Ime na lactation
Enweghị mgbochi ọ bụla maka ịgwọ ọrịa shuga mellitus nwere insulin n'oge afọ ime, n'ihi insulin anaghị agafe ihe mgbochi placental. Mgbe ị na-eme atụmatụ ịtụrụ ime na n’oge ya, ọ dị mkpa ime ka ọgwụgwọ shuga dị ike sie ike. Mkpa insulin na-agbadata n'oge ọnwa atọ nke mbụ nke afọ ime wee jiri nwayọ na nke abụọ na nke atọ.
N'oge na mgbe amuchara nwa, ihe ndi choro insulin nwere ike igbadata nke ukwuu. N'oge na-adịghị anya a mụsịrị nwa, mkpa ọ dị insulin na-alaghachi ngwa ngwa dị ka ọ dị tupu ime ime. Enweghị mgbochi ọ bụla na ọgwụgwọ ọrịa shuga mellitus nwere insulin n'oge a na-enye nwa ara. Agbanyeghị, ọ nwere ike ịdị mkpa iji belata insulin, yabụ, iji nlezianya nyocha maka ọnwa ole ọ dị mkpa tupu ịkwado mkpa insulin dị.
Ntụziaka pụrụ iche
Tupu ojiji, jiri nlezianya lelee ọdịdị nke ihe dị n'ime karama ahụ ma ejila ngwakọta Rosinsulin M 30/70 ma ọ bụrụ na, mgbe agwakọtara, nkwusioru ahụ nwere flakes ma ọ bụ ọ bụrụ na ntụpọ ọcha na-agbada na ala ma ọ bụ mgbidi nke karama ahụ, na-ekepụta mmetụta nke usoro ntu oyi.
Ejikwala ngwakọta Rosinsulin M 30/70 ma ọ bụrụ na, mgbe ịfechara, nkwụchi ahụ anaghị acha ọcha na igwe ojii.
Na-emegide usoro ịgwọ ọrịa insulin, ọ dị mkpa ileba anya mgbe niile itinye uche glucose ọbara.
Ihe kpatara hypoglycemia na mgbakwunye na insulin ịdoụbiga ọgwụ ike nwere ike ịbụ: nnọchi ọgwụ, ngbanye nri, vomiting, afọ ọsịsa, nchekasị anụ ahụ, ọrịa ndị na-ebelata mkpa insulin (ọrụ imeju na akụrụ na-emebi emebi, hypofunction nke adrenal cortex, pituitary ma ọ bụ thyroid gland), mgbanwe nke nsị, na na mmekorita ya na ogwu ndi ozo.
Singzọ ezighi ezi ma ọ bụ ihe mgbochi na nchịkwa insulin, karịsịa na ndị ọrịa nwere ọrịa shuga 1, nwere ike ibute hyperglycemia. Ọtụtụ mgbe, mgbaàmà mbụ nke hyperglycemia na-amalite nwayọọ nwayọọ karịa ọtụtụ awa ma ọ bụ ụbọchị. Ndị a gụnyere akpịrị ịkpọ nkụ, mmamịrị nke ukwuu, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, ọbara ọbara na ajị anụ, akpọnwụ akpịrị, enweghị agụụ, isi nke acetone na ikuku ikuku. Ọ bụrụ na agwọtaghị ya, hyperglycemia n'ụdị shuga 1 nwere ike ibute mmepe nke ọrịa ketoacidosis na-eyi ndụ egwu. Ekwesịrị idozi ọnụọgụ insulin maka arụ ọrụ thyroid, ọrịa Addison, hypopituitarism, ọrụ imeju na akụrụ, yana ọrịa mellitus n'ime ndị gbara afọ 65.
Ọ dịkwa mkpa iji dozigharị insulin insulin ma ọ bụrụ na onye ọrịa ahụ na-eme ka ahụrụ ọrụ ya dị elu ma ọ bụ gbanwee ụdị nri a na-emebu.
Ọrịa concoitant, ọkachasị ọrịa na ọnọdụ ya na ahụ ọkụ na-eme ka ebulite insulin.
Ime mgbanwe na ntụgharị site n'otu ụdị insulin gaa na nke ọzọ kwesịrị ka eme ya n'okpuru nlekọta dọkịta yana ileba anya nchịkọta glucose dị n'ọbara. Ọgwụ a na-ebelata mmanya nnabata.
N'ihi na enwere ike ịda mmiri na ụfọdụ catheters, a naghị atụ aro iji ọgwụ ahụ na nfuli insulin.
Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa
Na njikọta ebumnuche insulin, mgbanwe dị n'ụdị ya ma ọ bụ ọnụnọ nke nrụgide anụ ahụ ma ọ bụ nke uche, enwere ike belata ikike ịkwọ ụgbọala ma ọ bụ ijikwa usoro dị iche iche, yana itinye aka na ihe omume ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume nke uche na moto.
Dodoụbiga ya ókè
Mgbaàmà: na ịdoụbiga mmanya ókè, hypoglycemia nwere ike ịmalite.
Ọgwụgwọ: onye ọrịa ahụ nwere ike iwepụ hypoglycemia dị nwayọ site na itinye shuga ma ọ bụ nri nwere carbohydrate. Ya mere, a na-atụ aro ka ndị ọrịa nwere ọrịa shuga na-ebu shuga, swiiti, kuki ma ọ bụ ihe ọ fruitụ fruitụ mkpụrụ osisi dị ụtọ. N'okwu ikpe siri ike, mgbe onye ọrịa kwụsịrị ịmara, a na-edozi 40% ihe omvvvv
dextrose (glucose), na / m, s / c, in / in - glucagon. Mgbe ọ nwetasịrị onwe ya, a na-atụ aro onye ọrịa ka ọ rie nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.
Mkparịta ụka ọgwụ ọjọọ
E nwere ọtụtụ ọgwụ na-emetụta mkpa maka insulin. Hypoglycemic mmetụta nke insulin welie onu hypoglycemic ọgwụ ọjọọ, Mao inhibitors, Ace inhibitors, carbonic anhydrase inhibitors, nhọrọ beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic Steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium preparations nkwadebe nwere ethanol.
Hypoglycemic mmetụta nke insulin isi onu gbochie afọ, corticosteroids, thyroid hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium ọwa blockers ngwa ngwa, diazoxide, morphine, phenytoin, nicotine, sulfinpyrazone, epinephrine, histamine H 1 ihe nnabata.
N'okpuru mmetụta nke reserpine na salicylates, ma ike na-agwụ ike ma na-abawanye na ọrụ ọgwụ a ga-ekwe omume.
Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ
Ezubere ọgwụ a maka nchịkwa okpuru ala. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu, dabere n’ịchịkọta glucose dị n’ọbara. Na nkezi, kwa ụbọchị ọgwụ a sitere na 0.3 ruo 1 IU / kg body body, dabere na njirimara nke onye ọrịa na ịba ụba nke glucose n'ọbara.
Ihe a chọrọ kwa ụbọchị maka insulin nwere ike ịdị elu karịa n’ebe ndị ọrịa na - eguzogide insulin (dịka ọmụmaatụ, n’oge uto, yana n’ebe ndị ọrịa na - ebu oke ibu), ma belata obere n’ime ndị ọrịa nwere ọgwụ insulin na-emepụtagharị.
Okpomoku nke mmanu insulin kwesiri ino na okpomoku. Tupu ojiji, nkwanye ahụ ji nwayọ gwakọta ruo mgbe edo edo. A na-enyekarị ọgwụ a n'okpuru subcutaneously na apata ụkwụ. A pụkwara ime inje na mpaghara nke mgbidi ihu, ogwe aka ma ọ bụ mpaghara mpaghara akwara dị n'ubu. Site na iwebata ọgwụ n’apata apata, enwere mwepu nwayọ karịa mgbe etinyere n’akụkụ ndị ọzọ.
Okwesiri igbanwe ebe igba ogwu n’etiti mpaghara anatomical iji gbochie mmepe nke lipodystrophy.
Mgbe ị na-eji pensụ pensụl ọnye ọnụọgụ ọgwụ eji ejupụta tupu ọnụọgụ, ọ dị mkpa iji wepu sirinji mkpịsị na friji tupu ịmalite izi ka ọgwụ ahụ rute n ’ụlọ ahụ. Ọ dị mkpa ka ịgbakwunye nkwusioru nke ROSINSULIN M mix 30/70 na mkpịsị mkpụrụ sirinji ozugbo enwere ike. Mkpokọta nke ọma kwesịrị ịdị ọcha na igwe ojii. Ọ nweghị ọgwụ a ga-eji nkwụchi ọgwụ enwere ike iji ma ọ bụrụ na agbajikwa ya. Ọ dị mkpa na ị ga-agbaso ntuziaka maka iji mkpụrụ akwụkwọ sirinji enyere ya.
Ọrịa concoitant, nke na-efe efe ma na-efe efe, na -emekarị ahụ insulin nwere ahụ. Ọ ga-adị mkpa ịgbanwe nguhie ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa ndị akụrụ, akụrụ, ọrụ akwara, pituitary ma ọ bụ thyroid gland.
Mkpa maka ịhazigharị dose nwekwara ike ibilite mgbe ị na-agbanwe mmega ahụ ma ọ bụ nri onye ọrịa na-eri. Imezi dose mgbe ị na-ebufe onye ọrịa n’otu ụdị insulin na nke ọzọ.
Nsonaazụ
Ihe omume kachasị njọ na insulin bụ hypoglycemia. N'oge ọnwụnwa nke ụlọ ọgwụ, yana n'oge iji ọgwụ ahụ mgbe a tọhapụsịrị ya na ahịa ndị ahịa, a chọpụtara na ọnọdụ nke hypoglycemia dịgasị iche dabere na ọnụ ọgụgụ ndị ọrịa, usoro ị doụ ọgwụ ahụ, yana njikwa glycemic.
Na nmalite ọmụmụ ọgwụ insulin, njehie na-emegharị emegharị, ụkwara akwara na mmeghachi omume na saịtị ịgba ntụtụ (gụnyere mgbu, redness, urticaria, mbufụt, hematoma, ọzịza na itching na saịtị ịgba ntụtụ) nwere ike ime. Mgbaàmà ndị a anaghị adịte aka. Mmezi ngwa ngwa na njikwa glycemic nwere ike ibute ọnọdụ 'nnukwu mgbu neuropathy', nke na-agbanwegharị. Enstụgharị uche na ọgwụ insulin na mmụba dị mma n'ịchịkwa metabolism metabolism nwere ike ibute ịbelata nwa oge na ọnọdụ nke ọrịa mamịrị, ebe nkwalite ogologo oge na njikwa glycemic na-ebelata ohere nke inwe ọrịa mamị retinopathy.
Weputara udi ya na ihe mebere ya
Nkwusioru maka usoro ochichi ihe ochichi nke 100 IU / ml di na odidi:
- karama nke 5 na 10 ml,
- Cartridge 3 ml.
1 ml nke ọgwụ nwere:
- Ihe bụ isi bụ ọrụ insulin nke mkpụrụ ndụ mmadụ 100 IU.
- Ihe inyeaka: protamine sulfate (0.12 mg), glycerin (16 mg), mmiri maka ntụtụ (1 ml), metacresol (1.5 mg), crystalline phenol (0.65 mg), sodium hydrogen phosphate dihydrate (0.25) mg).
Mwepu nke nchịkwa subcutaneous nke 100 IU / ml dị n'ụdị: karama nke 5 na 10 ml, a kọọkụ nke 3 ml.
Mlọ ọgwụ
Nsonye zuru oke na ngosipụta nke mmetụta ahụ na-adabere na usoro onunu ogwu, usoro na ọnọdụ nke ịgba ọgwụ ahụ, ịta insulin. Ọgwụ nke insulinase n'ime akụrụ na-ebibi ọgwụ ahụ. Ọ na-amalite ime ihe dị ka ọkara otu awa mgbe nchịkwa, rute elu nke 3 awa 3-10 n’ahụ, kwụsịrị ime ihe mgbe otu ụbọchị gachara.
Formdị, ihe mejupụtara na usoro nke ọrụ
"Rosinsulin" na-ezo aka ọgwụ ọgwụ nke "hypoglycemic agents" otu. Dabere na ọsọ na oge ihe a na-eme, enwere:
A na-ebelata shuga n’otu ntabi anya! Ọrịa shuga n’afọ nwere ike ibute ọrịa dị iche iche, dịka nsogbu ọhụụ, akpụkpọ ahụ na ntutu isi, ọnya, ọria na ọbụna etuto ahụ! Ndị mmadụ kuziri ihe ilu iji mee ka ọkwa shuga ha dị mma. gụọ na.
- "Rosinsulin S" yana ogologo oge ana - eme,
- "Rosinsulin R" - na obere mkpụmkpụ,
- “Rosinsulin M” bụ ihe jikọtara ọnụ nke gụnyere insulin insulin 30% na 70% insulin-isophan.
A na - enweta insulin n'ahụ ahụ mmadụ site na mgbanwe DNA. Ntụziaka ahụ na-egosi na ụkpụrụ nke ihe a dabere na njikọta nke ihe mejupụtara ọgwụ ahụ na mkpụrụ ndụ yana imepụta insulin na-esote. N’ihi ya, njikọ nke enzymes dị mkpa maka ịrụ ọrụ nke ọma na-eme. Normalization nke ọkwa shuga na-apụta n'ihi metabolism nke intracellular na ịmịkọrọ zuru ezu. Dabere na ndị ọkachamara, a na-ahụ nsonaazụ nke ngwa a 1-2 awa mgbe nchịkwa n'okpuru anụahụ.
"Rosinsulin" bụ nkwusioru maka nchịkwa n'okpuru anụahụ. Ihe a rụpụtara bụ n'ihi ọdịnaya nke insulin-isophan.
N'èzí, ọgwụ na-acha ọcha na obere ntacha isi awọ. Na enweghị ịma jijiji, a na-ekewa ya n'ime mmiri mmiri doro anya ma na-akwali. Dịka ntuziaka ahụ si dị, “Rosinsulin” kwesịrị ịma jijiji tupu nchịkwa. Ọzọkwa, ihe mejupụtara ọgwụ ahụ nwere ihe ndị akọwapụtara na tebụl: