Avelox® (400 mg) Moxifloxacin

Ekele diri unu!

Onye dọkịta na-ahụ maka ụmụ nwanyị ka edepụtara m Avelox maka ya, yabụ na ụmụ nwoke nwere ike karịa ihe ọ bụla edepụtara n'okpuru, ọ ka mma ịghara ịgụ ya.

Afọ abụọ gara aga, edere m akwụkwọ nyocha na isiokwu "Enwere m ajọ ntutu"ya mere ekenyela m:

Mgbe ahụ enwere m nhụjuanya: ọgwụgwọ enyeghị nsonaazụ ozugbo. Ma n’oge a, ọ fọrọ obere ka ọ bụrụ otu.

Amaghị m ihe na-eme ahụ m, mana nsogbu nke smear jọrọ njọ bụ mkpụrụ ndụ ọbara dị elu -

bịara leta m ọzọ n’afọ a. O yikwara ka ọ dịghị ihe na-afụ ụfụ, enwere naanị ụfọdụ erughị ala, nke na-eme mgbe niile n'ụdị ndị a.

Na mkpokọta, abụ m onye nleta na-arịa ọrịa gynecology: nyocha nke ultrasound ugboro abụọ n'afọ na ndụmọdụ dị mkpa nke ọkachamara n'ọrịa ụmụ nwanyị na endocrinologist. Ihe mere bu na nyocha m nwere ogologo oge bụ hyperplasia endometrial.

N'oge na-adịbeghị anya, achọpụtara m na ọ bụ hyperplasia endometrial nwere ike ịkpasu ịrị elu leukocytes na smear - ebe ọ bụ na mkpali nke endometrium na-anọkarị na akpanwa.

Dọkịta ahụ kwusiri ike ọzọ ịme hysteroscopy, mana ule "ezi" dị mkpa maka usoro a. Iji mee nke a, ekenyela m kandụl mbụ, na mgbe ahụ - mgbe m gara leta dọkịta ọzọ, ọgwụ nje.

Onye ọkachamara n'ọrịa ụmụ nwanyị nyere ha iwu kandụl Fluomizinum.

Mana ọgwụgwọ ha, n'agbanyeghị na ọ dị mma, emeghị ka nsonaazụ smear ahụ ka njọ, - dị ka dọkịta si kwuo, ọ kara njọ.

Dịka ọkachamara n'ọrịa ụmụ nwanyị, amaghị m ihe o duziri ya - ka emechara, enweghị m ọnya ọ bụla n'ihi ultrasound - o nyere ọgwụ mgbochi ọgbọ ọhụrụ siri ike - Avelox.

Na-emesi m obi ike na "ọ ga-enyere aka ozugbo!", Ọzọkwa enyere m ọgwụ ọzọ ọzọ nke ga-egbochi mpụta nke dysbiosis na thread.

Na mkpokọta, ọgwụgwọ m bara nnukwu ego!

Tupu iwere akpa M, dị ka ọ dị na mbụ, na-agụ nyocha, site na nke ọ bịara doo anya na anụ ahụ m nwere ike ịnyefe Avelox, ebe m nwere nsogbu na ọnya afọ, yananka putaraọ fọrọ nke nta ka ọrịa niile nyere aka.

Ngwa

Ejiri m mbadamba Aletx 1 otu ụbọchị mgbe nri gasịrị, were mmiri sachaa ya maka izu abụọ.

Agbalịrị m ịhapụ ịgbanye oge iwere ya na enweghị ibu na-enweghị isi n'ahụ.

Ihe na-egosi

Ọrịa na-efe efe na mkpali na ndị okenye kpatara microorganisms nke maara ọgwụ ahụ: nnukwu sinusitis, pneumonia nke obodo na-enweta (gụnyere nje microorganism na-egbochi ọtụtụ nje mgbochi), njupụta nke bronchitis na-adịghị ala ala, ọrịa na-adịghị agbanwe agbanwe nke akpụkpọ ahụ na anụ ahụ dị nro, ọrịa na-agbagha mgbagwoju anya nke akpụkpọ ahụ na subcutaneous ihe owuwu (tinyere ụkwụ ọrịa mamịrị), ọrịa intra-abdominal, gụnyere ọrịa polymicrobial, gụnyere Ọkpụkpụ intraperitoneal, ọrịa mgbu nke akụkụ pelvic (gụnyere salpingitis na endometritis).

Ihe ngbanwe

ime, lactation (inye ara),
ụmụaka na ndị na-eto eto nọ n’agbata afọ 18,
hypersensitivity na moxifloxacin na akụkụ ndị ọzọ nke ọgwụ.

Nsonaazụ

Mgbatị oge nke QT (oge ụfọdụ na ndị ọrịa nwere hypokalemia concomitant, mgbe ụfọdụ na ndị ọrịa ndị ọzọ), tachycardia na vasodilation (iwepụ ihu), ọbara ọgbụgba, ọnya ọgbụgba, nkụda mmụọ, achricular tachyarrhythmias, nonspecific arrhythmias (gụnyere extrasystole) (ihe egwu ventricular arrhythmias dị ka “pirouette”) ma ọ bụ njide obi nwere tumadi ndị mmadụ nwere ọnọdụ na-emetụta arrhythmias, dị ka bradycardia dị egwu, nnukwu myocardial ischemia, mkpụmkpụ ume, gụnyere ac mgbakọ na mwepụ, ọgbụgbọ, ọgbụgbọ, mgbu afọ, afọ ọsịsa, anorexia, afọ ntachi, dyspepsia, flatulence, gastroenteritis (ma e wezụga ọrịa gastroenteritis), stomatitis, pseudomembranous colitis (na ọrịa ndị na - esitekarị na nsogbu ndị dị egwu), jaundice, hepatitis (tumadi cholestate ), akpịrị ịkpọ nkụ, isi ọwụwa, ọgba aghara, ọgba aghara, nsogbu ụra, ụjọ, ụra, nchekasị, ọrụ psychomotor mụbara, njikota nsogbu (gụnyere ọgba aghara n'ihi ọgbụgbọ. M, n'ọnọdụ ndị a na-adịghị ahụkebe, na-eduga na mmerụ ahụ n'ihi ọdịda, karịsịa na ndị agadi agadi), ihe ọdịdọ nwere ọtụtụ ngosipụta ahụike (gụnyere gụnyere ihe ọdịdọ nke oke mal), ntị na-adịghị mma, nsogbu na-ekwu okwu, amnesia, nkụda mmụọ (n'ọnọdụ ndị ọ na-anaghị adịkarị, omume nwere ike imerụ onwe ya ahụ) enwere ike, mmeghachi omume psychotic (enwere ike igosipụta ya na mmadụ imerụ onwe ya ahụ), nhụsianya uto, ọgba aghara a na-ahụ anya (ọ na-acha ọkụ, belata acuity visual, diplopia, ọkachasị yana yana ọgbụgbọ na ọgba aghara), tinnitus, ọgba aghara, gụnyere nsogbu ọgbụgba, ọnwụ nke uto, anaemia, leukopenia (gụnyere neutropenia), thrombosis. cytopenia, thrombocytosis, ogologo oge prothrombin na belatara INR, ọrịa ogbu na nkwonkwo, myalgia, akwara, olu na-ebelata ụda, akwara na-apụnara mmadụ ihe isi ike, ọnya ọgbụgba, akpịrị ịkpọ nkụ (nke ọria ọria ma ọ bụ belatara mmiri mmiri), ụkwara akụrụ, ọdịda akụrụ n'ihi ọdịda akụrụ. , nke nwere ike ibute mmebi akụrụ (ọkachasị ndị agadi nwere ọrịa akwara nwere nsogbu akwara), mmeghachi omume anụ ahụ, dịka ọmụmaatụ, Stevens-Johnson syndrome ma ọ bụ ọgwụ na-egbu egbu. epidermal necrolysis (nwere ike igbu mmadụ), urticaria, pruritus, ihe ọkụ ọkụ, eosinophilia, mmeghachi omume anaphylactic / anaphylactoid, angioedema, gụnyere ọrịa laryngeal edema (nwere ike igbu ndụ), oke ikuku anaphylactic (gụnyere ndụ egwu), ọrịa ịba (gụnyere mgbaàmà nke ahụike na-adịghị mma, mgbu na-enweghị isi na ọsụsọ), ọzịza.

Ngwakọta

Ihe na-arụ ọrụ: moxifloxacin hydrochloride - 436.8 mg

Ọdịdị

Mbadamba ndị ahụ, dịka ị hụrụ, buru nnukwu ibu, mana n'ihi ọdịdị ha dị ogologo, ha na-a drunkụbiga mmanya ókè.

Mpempe usoro onunu ogwu

Mkpụrụ mbadamba ọgwụ mkpuchi 400 mg

Otu mbadamba ihe

akike - moxifloxacin hydrochloride 436.8 mg,

(nke kwekọrọ na moxifloxacin 400.0 mg),

ndị na-ebu ụzọ: lactose monohydrate, celclose microcrystalline, shịum croscarmellose, magnesium stearate,

ihe mejupụtara shei: iron oxide red, hypromellose, macrogol 4000, titanium dioxide.

Mbadamba nkume uhie na-acha uhie uhie, nke gbara agba, ihe dị ka 17 mm ogologo na ihe dịka 7 mm n'obosara, akara “M 400” n'otu akụkụ yana “BAYER” n'akụkụ nke ọzọ.

Ngwongwo ogwu

Mlọ ọgwụ

Mwepu na bioavailability

Mgbe a na -ekwu ya site n'okwu ọnụ, a na-etinye moxifloxacin ngwa ngwa ọ fọkwara nke nta. Ezigbo bioavailability dị ihe dịka 91%.

The pharmacokinetics nke moxifloxacin mgbe ewere ya na ọgwụ nke 50 ruo 1200 mg otu oge, yana 600 mg / ụbọchị maka ụbọchị 10, bụ ahịrị. Ekwadoro steeti etolite n’ime ụbọchị 3.

Mgbe otu mgmloloxacin nke 400 mg, moxifloxacin, agarịrị itinye uche kachasị (C max) n'ime ọbara n'ime awa 0,5-4 ma ọ bụ 3.1 mg / l. Ọnụ ọgụgụ kasị elu nke plasma na steeti kwụsiri ike (400 mg otu ugboro kwa ụbọchị) bụ 3.2 na 0.6 mg / L, n'otu n'otu.

Mgbe ị na-ewere moxifloxacin na nri, enwere ntakịrị mmụba oge iji rute Cmax (ka elekere abụọ) na ntakịrị mbelata na Cmax (ihe dịka 16%), ebe oge iwere anaghị agbanwe. Agbanyeghị, data ndị a enweghị uru ọria, ebe ogo nke AUC / MIC na-ebu amụma amụma antimicrobial nke quinolones. Ya mere, enwere ike iji ọgwụ ahụ n'agbanyeghị nri nri.

A na-ekesa Moxifloxacin ngwa ngwa n’elu akwa extravascular. Onu ogugu n’ogiri uzo AUC pharmacokinetic curve (AUCnorm = 6 n'arọ * awa / L) nke nwere oke ihe nlere anya (Vss) nke moxifloxacin nke odi 2 L / n'arọ. Oke moxifloxacin na mmiri dị elu karịa na plasma. Na nyocha nke viro na ọmụmụ vivo na mkpokọta site na 0.02 ruo 2 ml / l, njikọta nke moxifloxacin ka protein na-agbago ihe dịka 45%, n'agbanyeghị ị ofụ ọgwụ ahụ.

Moxifloxacin nwere ihe jikọrọ ya na plasma albumin.

Enwere ọnụ ọgụgụ dị elu na ntinye uche n'efu> 10xMIC n'ihi olu dị ala.

Ọgwụ ndị dị elu nke ọgwụ ahụ, karịrị ndị ahụ na plasma, ka a na-emepụta na ngụgụ ngụgụ (mmiri epithelial, alveolar macrophages, anụ ahụ), na sinuses na polyps, na mmepe nke mbufụt. N'okwu mmiri, mmiri ọgwụ n'etiti (intermuscular na subcutaneous), a na-ekpebi nnukwu ị ofụ ọgwụ ahụ na steeti efu.

Na mgbakwunye, ọgwụ ndị dị elu nke ọgwụ na-ekpebisi ike na akwara afọ na ọwara mmiri, yana akụkụ akụkụ nke nwanyi.

Mgbe otu moxifloxacin 400 mg, na ụzọ abụọ nke nchịkwa, enwere ike tufuo kachasị dị ka atụnyere plasma ịta n'ụdị anụ ahụ dị iche iche.

Mgbe ọ gafesịrị usoro nke biotransformation nke abụọ, moxifloxacin na-apụ apụ n'ahụ site na akụrụ na eriri afọ (GIT) na-agbanweghi agbanwe yana n'ụdị sulfo sulfo na-adịghị arụ ọrụ (M1) na glucuronides (M2). A na-emetụta metabolism ndị a naanị maka ahụ mmadụ mana ha enweghị ọrụ antimicrobial. Nnyocha nke mmekọrịta nke ọgwụ metabolikokinetic na ọgwụ ndị ọzọ gosipụtara na moxifloxacin na-abụghị biotransformed site na sistemụ microsomal cytochrome P450.

N'agbanyeghị usoro nke ngwa ahụ, a na-ahụ metabolites M1 na M2 na plasma ọbara na mkpo ya dị ala karịa ịta moxifloxacin na-agbanweghị.

Ọkara ndụ nke ọgwụ ahụ site na plasma dị ihe dị ka awa iri na abụọ. Nchịkọta ngụkọta oge mgbe ịwachara ọgwụ nke 400 mg sitere na 179 ruo 246 ml / min. Mwepụ ntaramahụhụ nke ihe dịka 24-53 ml / min na-apụta site na tubular reabsorption nke ọgwụ na akụrụ. Nchịkọta ojiji nke ranitidine na probenecid anaghị emetụta mkpochapụ akụrụ gbasara ọgwụ. Na agbanyeghị ụzọ isi nchịkwa, moxifloxacin ihe a na-amalite bụ ihe fọrọ nke nta ka ọ bụrụ 96-98% metabolized ka metabolites nke ọkwa nke abụọ nke metabolism na-enweghị ihe ịrịba ama nke metabolism oxidative.

Pharmacokinetics na otu ọrịa dị iche iche

E guzobeghị ọdịiche dị iche iche na ọgwụ ọgwụ nke moxifloxacin.

Paul Ndi ekpughere di iche-iche (33%) na pharmacokinetics (AUC, Cmax) n’etiti ụmụ nwoke na ụmụ nwanyị. Nkọwa ndi ekpughere ekpugheghi na AUC na Cmax site na ndi di iche n’otinye aru karia nke nwoke. Ya mere, ha abughi ihe di omimi.

Agụrụ ọdịiche dị n'etiti mmekọ nwoke na nwoke na Caucasoid, Japanese, Negroid, na agbụrụ ndị ọzọ. Egosibeghi ogwu di iche na ogwu nke ogwu moxifloxacin.

Emebeghị ka ogwu ọgwụ nke moxifloxacin na ụmụaka.

Onweghi mgbanwe di omimi na pharmacokinetics nke moxifloxacin na ndi oria nwere nsogbu ezughi oke oru (tinyere ndi oria ndi ocha nke 1/100 and 1/1000 and 1/10 0000 and 1 / 1,000)

- mgbanwe na mkpokọta thromboplastin

- mmeghachi omume anaphylactic / anafilactoid, nfụkasị / angioedema, gụnyere edema ede (nke nwere ike igbu mmadụ)

- obi uto, obi erughi ala (na mgbe ufodu enwere ike gosiputa akparamagwa nke imebi onwe ya, dika echiche igbu onwe ya ma obu igbali onwe onye)

- hyposthesia, imebi isi, tinyere ọrịa ọgbụgba

- nrọ mkpali, njikwa nkwonkwo (gụnyere uru isi, tumadi n'ihi ọgbụgbọ ma ọ bụ vertigo (ọ na-eduga ịdaba na mmerụ ahụ, ọkachasị ndị ọrịa nọ n'ọnọdụ dị ụkọ), ihe ọdịdọ dị iche iche na - egosipụta ya (gụnyere ndị juputara na ya), ntị na-adịghị mma, nsogbu ụbụrụ, amnesia

- neuropathy na-emetụta ala na polyneuropathy

- tinnitus, enweghi ntị, tinyere ntị chiri (na - atụgharịghachi)

- ike gwụrụ, hypotension, ọbara mgbali, achricular tachyarrhythmias

- dysphagia, stomatitis, pseudomembranous colitis (ejikọtara ya na nsogbu ndị na - egbu ndụ na obere nsogbu), jaundice, ịba ọcha n'anya (tumadi cholestatic)

- eriri afọ, olu na -eme ka uru ahụ na akwara ike, ike ọgwụgwụ

- arụrụ ọrụ gbasara akụrụ, ọdịda akụrụ (n'ihi oke mmiri, ọkachasị ndị ọrịa nwere nsogbu gbasara akụrụ)

Mwepụta wepụtara ya na ihe mejupụtara

Avelox dị n'ụdị mbadamba mkpuchi na ngwakọta infusion.

Ihe na-arụ ọrụ bụ moxifloxacin: na mbadamba 1 na 250 ml nke ihe ngwọta - 400 mg.

Ndị nwere mbadamba mbadamba: lactose monohydrate, microcrystalline cellulose, ssumum croscarmellose, magnesium stearate, hypromellose, iron ironide, macrogol 4000, titanium dioxide.

Ihe inyeaka nke ihe ngwọta: 1M hydrochloric acid, sodium chloride, 2M sodium hydroxide solution, mmiri maka ntụtụ.

Mlọ ọgwụ

Moxifloxacin (aha kemịkal - 8-methoxyfluoroquinolone) bụ ọgwụ nje na - egbochi ọgwụ nje. Mmetụta nje ya na-akpata n'ihi eziokwu na ọ bụ onye na-egbochi topoisomerases nke nje na nke II. Nke a na-akpata ọgba aghara na usoro ntụgharị, ndozi na imepụtaghachi ihe dị na biosynthesis DNA nke mkpụrụ ndụ microbial, n'ihi ya, na-eduga na ọnwụ nke ikpeazụ.

Obere nke nje moxifloxacin nke moxifloxacin bụ ihe niile na-atakarị iche na ọnụnọ inhibitory pere mpe. Achọpụtaghị ọrụ ọgwụ nje nke Avelox site na usoro ndị na-akpalite mmepe nke iguzogide tetracyclines, penicillins, macrolides, aminoglycosides na cephalosporins. Achọpụtaghị mgbochi obe n'etiti ndị otu ọgwụ ọgwụ antibacterial na moxifloxacin. Edebanyeghị okwu nkwụghachi nke plasmid ugbu a. Ogologo oge ihe niile na-eme ka ndị mmadụ sie ike dị oke obere (10 -7 ‒10 -10).

Nguzogide nye Apitix na - eto ogologo oge site na otutu mmụba.

Nkpugheghari ugboro ugboro na ntinye aka nke Avelox n’ime mkpoko na-erughi uru nke obere mkpado ihe mgbochi (MIC), na-eduga ná ntakịrị mmụba na MIC.

Enwere nsogbu nke obe nguzogide na quinolones. Ka osila dị, microorganisms anaerobic na gram-positive nke na-eguzogide na quinolones ndị ọzọ na-egosipụta arụmọrụ moxifloxacin.

O guzosie ike na mgbakwunye nke igwe methoxy nke di na onodu C8 na moxifloxacin mololu nke moxifloxacin na-abawanye oru ya ma na - egbochi ogba aghara nje di nma.

Ihe mgbakwunye nke otu ndi ahu ndi a na-ejighari ndi mmadu na onodu C7 na - egbochi nguzosi ike oru ya na usoro iguzogide fluoroquinolones.

Na vitro moxifloxacin na-arụ ọrụ megide nje dị iche iche nke gram-positive na gram na-adịghị mma, anaerobes, microorganisms na-eguzogide acid na acid (dịka Legionella spp., Chlamydia spp., Mycoplasma spp.), Yana microorganisms na-eguzogide macrolide na ọgwụ nje β-lactam.

N'oge a, a na-amata ọmụmụ abụọ na ndị ọrụ afọ ofufo na nke mgbanwe na microflora eriri afọ ka a mụsịrị nchịkwa nke moxifloxacin. Ha gosipụtara mbelata nke mkpokọta nke Klebsiella spp., Escherichia coli, Enterococcus spp., Bacteroides vulgates, Bacillus spp., Yana anaerobes Peptostreptococcus spp., Eubacterium spp., Bifidobacterium spp. A gbanwere mgbanwe ndị a maka izu abụọ. Achọpụtabeghị ihe ngbu Clostridium.

Na vitro moxifloxacin gosipụtara ọrụ antibacterial dị elu megide microorganisms ndị a:

• nje ndị na-egbu gram: Gardnerella vaginalis, ụdị methicillin nwere mmetụta nke coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. epidermidis, S.hominis, S. haemolyticus), staphylococcus aureus (ụdọ na-egosi nnwere onwe na methicillin), Ahụ ike prọonia na Streptococcus gụnyere nje na-eguzogide penisilini, na nje nwere ọtụtụ ọgwụ mgbochi, yana ụdị na-eguzogide ọgwụ abụọ ma ọ bụ karịa, nke gụnyere trimethoprim / sulfamethoxazole, penicillin (MIC karịa 2 μg / ml), tetracyclines, cephalosporins nke abụọ (dịka ọmụmaatụ cefuroxime), macrolides, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus pyrogenes vita vidititit vita, na-eme ya, na-ahụ ya. , S. thermophilus, S. mutans, S. sa livarius, S. sanguinis, S. mitis), ndị na-akpọ milptote Streptococcus (S. intermedins, S. constellatus, S. anginosus),
• nje gram na-adịghị mma: Proteus vulgaris, Haemophilus parainfluenzae, Haemophilus influenzae (gụnyere ụrọ na-akpụ akpụ na anaghị arụ β-lactamases), Acinetobacter baumannii, Moraxella catarrhalis (gụnyere ụdị na-emepụta ma na-anaghị emepụta β-lactamases, Bordella Pionella, Bordella pelioella, Bordella Pionella
• microorganisms anaerobic: Propionibacterium spp., Fusobacterium spp., Prevotella spp., Porphyromonas spp.,
• microorganisms atypical: Coxiella burnetii, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae.

Ihe ndị a na-ahụ anya na-emetụta moxifloxacin:

• Nje bacteria dị mma: Enterococcus faecium, Enterococcus avium, Enterococcus faecalis (naanị nwere nsogbu ndị nwoke na-arịa ga-eme ka mkpụrụ ọgwụ mesamicin na vancomycin),
• nje gram na-adịghị mma: Providencia spp. (P. stuartii, P. rettgeri), Escherichia coli, Neisseria gonorrhoeae, Klebsiella oxytoca, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Proteus mirabilis, Enterobacter spp. (E. sizakii, E. intermedius, E. aerogenes), Enterobacter cloacae, Stenotrophomonas maltophilia, Burkholderia cepacia, fluorescens Pseudomonas, Ptoudomonas, Pọgommeas agglomerans,
• microorganisms anaerobic: Clostridium spp., Peptostreptococcus spp., Bacteroides spp. (B. vulgaris, B. fragilis, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron).

Ihe ndị na-esonụ microorganisms na-egosipụta nguzogide ọgwụ:

• nje gram-nke oma: methicillin na –eche ike nke coagulase-sta staloloccci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. hominis, S. haemolyticus), ofloxacin / methicillin na-egbochi ụdị nke staphylococcus aureus,
• Nje bacteria na-adịghị mma: Pseudomonas aeruginosa.

A naghị akwado iji ojiji nke Avelox na ọgwụgwọ nke ọrịa nke metụtara ọrịa staphylococcus aureus na nkwenye siri ike maka methicillin (MRSA). N'ọnọdụ nke MRSA, enwere ọgwụ mgbochi ọgwụ oputara ekwenye, ekwesịrị ịgụta ọgwụ kwesiri ekwesi.

Maka ụfọdụ ụdị, nnweta enwetara nwere ike gbasaa n'ụzọ dị iche iche ka oge na-aga ma dabere na ọnọdụ mpaghara ndị ọrịa. Maka nke a, mgbe ị na-anwale ụdị nrụgide, a na-atụ aro ka ịmụ ihe banyere obodo banyere nguzogide, karịchaa n'ịgwọ ọrịa ndị siri ike.

Ọ bụrụ na a na-agwọ ndị ọrịa n'ụlọ ọgwụ, uru nke mpaghara ahụ dị n'okpuru usoro ọgwụ pharmacokinetic "ịta - oge" (AUC) / MIC₉₀ karịrị 125, na ọdịnaya kachasị nke moxifloxacin na plasma ọbara (C_max) / MIC₉₀ nọ na etiti nke 8-10, nke a pụtara ịkọ nkọ na nkwalite ahụike nke onye ọrịa. N'ime ụlọ ọgwụ, ndị a na-egosipụtakarị ihe na-erughị (AUC / MIC)₉₀ karịrị 30-40).

Mgbe ị na-ewere ụdị ọnụ nke Avelox: yana nkezi MIC₉₀ 0.125 mg / ml AUIC (mpaghara n'okpuru usoro mgbochi, i.e. AUC / MIC ruru₉₀) hà ka 279, yana C_max/ MIC₉₀ - 23.6. Na ụkpụrụ MIC₉₀ 0.25 mg / ml na 0,5 mg / ml AUIC na ụkpụrụ C_max/ MIC₉₀ dika ikpe 140 na 11.8 na nke mbu na 70 na 5.9 na nke abụọ.

Na infusion intravenous: yana nkezi MIC₉₀ 0.125 mg / ml AUIC bụ 313 na C_max/ MIC₉₀ - 32.5. Na ụkpụrụ MIC₉₀ 0.25 mg / ml na 0,5 mg / ml AUIC na ụkpụrụ C_max/ MIC₉₀ dị ka 156 na 16.2 na nke mbụ na 78 na 8.1 na nke abụọ.

Mlọ ọgwụ

Mgbe ị na-ewere Avelox n'ime, a na-etinye moxifloxacin na oke ọsọ na ọ fọrọ nke nta ka ọ bụrụ kpamkpam. Ndụ ya zuru oke bụ ihe dịka 91%. O gosiputara na ndi ogwu nke ogwu a nwere otu uzo na 50-1200 mg, yana ogwu Avelox n’ime onodu ubochi 600 mg rue ubochi iri. Ego oruru nke obodo nweburu n'ime ubochi ato.

Mgbe otu mgmg nke 400 mg nke Avelox, a na-enweta ntinye kachasị na ọbara na elekere 0.5-4 ma ọ bụ 3.1 mg / l. Site na nchịkwa ọnụ nke 400 mg nke ọgwụ otu ugboro kwa ụbọchị, ohere kachasị na nke kacha nta nke ihe dị na ọbara bụ 3.2 mg / L na 0.6 mg / L, n'otu n'otu. Mgbe moxifloxacin batara nri, enwere ịba ụba n'oge iji rute ịta kachasị (ihe dị ka elekere abụọ) na mbelata ntakịrị na mkpokọta uche (ihe dịka 16%). N'okwu a, oge iwere na-agbanwe agbanwe. Agbanyeghị, data ndị a enweghị isi ọrụ nyocha, ya mere Avelox nwere ike itinye n'ọrụ n'agbanyeghị nri nri.

Mgbe otu ngwakọta nke Avelox dị na pọọg nke 400 mg maka elekere 1, ntinye uche nke ihe ahụ ruru na njedebe nke infusion yana ihe dịka 4.1 mg / l, nke kwekọrọ na mmụba nke ihe dịka 26% ma e jiri ya tụnyere ọnụ ahịa parameto a na nchịkwa ọnụ nke moxifloxacin.

Nkpughepuo moxifloxacin, nke onye gosiputara site na AUC egosi, kariri nke onu ogugu nke moxifloxacin. Ezigbo bioavailability dị ihe dịka 91%. Mgbe ugboro ugboro infusvenous infusions nke Avelox na a dose nke 400 mg adịgide 1 awa 1 oge kwa ụbọchị, kacha na kacha nta anya nke moxifloxacin na ọbara dịgasị iche iche nke 4.1-5.9 mg / l na 0.43-0.84 mg / l, karị. A na-enweta ihe nkwụsi ike nke 4.4 mg / L na njedebe nke mkpụrụ.

A na-ekesa ọgwụ ngwa ngwa n’akwara na akwara. Ogo ya nke metụtara mgbochi protein (ọkachasị albumin) bụ ihe dịka 45%. Olu nke nkesa ruru ihe ruru 2 l / n'arọ.

Ihe dị mkpa nke moxifloxacin, karịa ndị nọ na plasma ọbara, na-edekọ ha na mkpali foci (ọnya afọ ya na ọnya anụ ahụ), akpa ume (gụnyere alveolar macrophages na epithelial fluid), polyps na sinuses (ethmoid na maxillary sinuses). N'ụbụrụ na mmiri dị n'etiti, a na-ekpebi ihe dị n'ọrụ nke Avelox n'ụdị ya (na-ejikọghị protein) yana n'ọtụtụ dị elu karịa na plasma ọbara. Ọzọkwa, a na-ahụ moxifloxacin dị elu n'ahụ akụkụ ahụ nke nwanyị, mmiri nke ahụ na - anụ ahụ.

Moxifloxacin na-etinye aka na usoro nke biotransformation nke ngalaba nke abụọ ma ewepụta ya n'ahụ na mmamịrị na ahụ. Ọzọkwa, a na-ahụta ya n'ụdị na-agbanweghi agbanwe yana n'ụdị sulfo ogige (M1) na glucuronides (M2), nke na-enweghị ọrụ ọgwụ ọgwụ.

Ọgwụ a adịghị etinye aka na mmeghachi omume biochemical n'ihi ikpughe sistemụ microsomal nke cytochrome P₄₅₀. Plasma nwere nke M1 na M2 metabolites dị ala karịa nke ndị nne na nna nwere. Nsonaazụ nke ọmụmụ ndị pụtara na-egosi na enweghị mmetụta na-adịghị mma nke metabolites ndị a n'ahụ ahụ n'ihe gbasara nnabata ha na nchekwa ha.

Ọkara ọkara nke moxifloxacin bụ ihe dị ka awa iri na abụọ. Ná nkezi, ngụkọta akwụkwọ maka nchịkwa ọgwụ na ọgwụ ọgwụ ruru 400 mg bụ 179-246 l / min. Mkpuchi ntaramahụhụ ruru 24-53 ml / min. Nke a na-akwado nkwụghachi azụ tubular nke ihe ahụ.

Ọha moxifloxacin na oge 2 metabolites bụ ihe dịka 96-98%, nke na-egosi enweghị metabolism oxidative. Ihe dị ka pacenti iri abụọ na abụọ (22mg) nke ọgwụ a na-agbanweghi agbanwe na mmamịrị ya, ihe dịka pacenti iri abụọ na isii.

Mgbe ị na-amụ ọgwụ pharmacokinetics nke moxifloxacin na ụmụ nwoke na ụmụ nwanyị, AUC na mkpokọta kachasị nwere ihe dị iche na 33%. Nnabata nke ihe ahu abughi ihe di na okike. Ọdịiche dị na AUC na ntinye uche kachasị bụ n'ihi ọdịiche dị na oke anụ ahụ, ọ bụghị nke nwoke na nwanyị, na enweghị uru ọhụụ.

Achọpụtabeghị ọdịiche dị na pharmacokinetics nke moxifloxacin na ndị ọrịa nke afọ dị iche iche ma bụrụ ndị agbụrụ iche. A ghotachazị ọgwụ ọgwụ nke moxifloxacin n’ime ụmụaka nke ọma.

N'ime ndị ọrịa na-ahụkarị ọrịa elekere anya ogologo oge na outpatient ma ọ bụ usoro ọgwụgwọ na-aga n'ihu, yana ndị ọrịa nwere ezinaụlọ gbasara ọrịa (gụnyere ndị ọrịa nwere CC ihe na-erughị 30 ml / min / 1.73 m 2), a chọpụtaghị mgbanwe dị ukwuu na pharmacokinetics nke moxifloxacin. Nnukwu ọdịiche dị na ịta moxifloxacin na ndị ọrịa nwere ọrụ imeju na-arụ ọrụ (klas A na B dị ka ọnụ ọgụgụ ụmụaka-Pugh) ma e jiri ya tụnyere ndị ọrịa nwere ọrụ imeju nkịtị na ndị ọrụ afọ ofufo nwere ahụike anaghị anọkwa.

Ihe ngosi maka ojiji

Dịka ntuziaka ahụ si dị, Avelox 400 mg ka edepụtara maka:

• Usoro ndị metụtara akpa ume na akụkụ akụkụ nke ENT,
• Ọrịa intraabdominal na urogenital,
• Ọrịa na - efe efe nke anụ ahụ dị nro na anụ ahụ.

A na-egosipụta ọrụ Avelox n'ihe metụtara ọtụtụ gram-positive na gram-microorganisms, nje na-eguzogide ọgwụ beta-lactam na ọgwụ nje macrolide, nje na-egbochi acid na ụdị microorganisms, yana nje nje anaerobic na-eguzogide ọgwụ.

Ihe ngbanwe

Ntuziaka maka Avelox na-egosi na a naghị anabata ojiji ya na ọrịa dịka pseudomembranous colitis na nnukwu akụrụ ọdịda. Amachibidoro ịillsụ ọgwụ maka ụmụ nwanyị dị ime na ndị na-enye nwa ara, ụmụaka na-erubeghị afọ 18 yana ndị nwere nsogbu ọ bụla nke ọgwụ ahụ. Kpachara anya dị mkpa mgbe ị na-ede akwụkwọ maka ndị ọrịa nwere ọrịa nke usoro akwara ozi, na-atụ aro na ọ ga-ekwe omume ụdị ọdịdọ ahụ. Ọrịa ndị dị ka ọrịa imeju, ischemia akwara, bradycardia, hypokalemia bụkwa ihe mere eji akpachara anya na nhọpụta nke Aveloks.

Ntuziaka maka iji Avelox: usoro na usoro onunu ogwu

Enwere ike ị nweta apootu n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri ị na-eri. Mbadamba mbadamba ihe ndia nile bu ihe apughi imebi ya. Ọkara ndụ nke ọgwụ ahụ bụ usoro dị ogologo, yabụ ọ ezuola ị takeụ ọgwụ ahụ otu ugboro n'ụbọchị.

Ọgwụ ọgwụgwọ kwa ụbọchị nke Avelox bụ 400 mg. Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ ngwa ngwa ma ọ fọrọ nke nta ka ọ bụrụ kpamkpam. A na-ahụ ọkwa kachasị elu nke ọgwụ n’ọbara mgbe ejiri otu oge gachaa mgbe ọ bụla awa nke 0.5-4 site n’oge ọchịchị. A nweta ọkwa Plasma moxifloxacin kwụ chịm pụtara mgbe abalị atọ ejiri ya.

A na-eme ọgwụgwọ ọrịa infusion na mmalite ọgwụgwọ yana iji nnyefe ọzọ nke onye ọrịa na iji Avelox na mbadamba, ma ọ bụ ejiri ya ruo mgbe ọ gbakere.

Dabere na ọrịa ahụ, ogologo oge nke ọgwụgwọ bụ ụbọchị 7-10.

Nsonaazụ

Mmeghachi omume ọjọọ na-abịakarị ezughi oke, dabere na iwu nke dosing. Avelox nwere ike ibute nsogbu ndị a:

• Ọgbụgbọ, ọgbụgbọ, mgbu nke afọ, oke uto, stomatitis, afọ ọsịsa.
• Ọbara mgbali elu, obi mgbu, palpation, mmụba ọbara,
• Dizzness, nsogbu ihi ụra, ịda mba, nchegbu, ọgba aghara, adịghị ike nke izugbe,
• Azụ mgbu, ihe mgbu na akwara na nkwonkwo, tendovaginitis, akaị mgbu,
• Itching, akpụkpọ rashes,
• Ọrịa hyperglycemia, hyperlipidemia, hyperuricemia,
• General malaise, ọzịza.

Dodoụbiga ya ókè

N'oge a, enwere obere ozi gbasara ịdoụbiga mmanya ókè nke Avelox. Site n'iji otu ọgwụ ahụ mee ihe na ọgwụ ruru ihe ruru 1200 mg ma ọ bụ mgbe etinyere ya na ọgwụ ọ na-akarịghị 600 mg, ọ nweghị ihe ọ bụla edere edere maka ụbọchị iri.

N'ihe banyere ịdoụbiga mmanya ókè, ọ dị mkpa iji nlezianya mụọ nyocha ụlọ ọgwụ banyere ọnọdụ onye ọrịa ma dezie usoro ọgwụgwọ symptomatic yana yana nyochaa ECG.

Inye ikuku nke mmanu emechu aru ozugbo anabatabeghi nke moxifloxacin nye ahu ya na - enyere aka zere oke ikpughe ogwu a ma obu iribiga ya oke.

Ntụziaka pụrụ iche

Ọ bụrụ na mgbu dị na nkwonkwo ma ọ bụ akwara mgbe ị na-ewere Avelox, a na-ehichapụ ọgwụ ahụ iji gbochie ọgbụgba ahụ.

N'ime ndị ọrịa nwere Akwụkwụ na-adọ, Avelox nwere ike ịkpalite ọdịdọ.

Site na mmepe nke nnukwu afọ ọsịsa ka ị na-ewere Avelox, a kagbuo ya.

Nri nke antacids na enterosorbents, yana ọgwụ ndị gụnyere iron, aluminom na magnesium kwesịrị ime n'oge dị iche iche na Avelox, ọdịiche ahụ kwesịrị ịdịkarịa ala 4.

A dịghị eji Avelox agwọ ụmụaka.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Ojiji nke Avelox nwere ike ibute nsogbu na ndị ọrịa mgbe ị na-anya ụgbọ ala ma na-arụ ụdị ọrụ ndị ọzọ dị ize ndụ nke chọrọ ịbawanye ụba na mmeghachi omume psychomotor ozugbo, nke a bụ n'ihi nsonaazụ ụfọdụ ọgwụ ahụ (nhụjuhụ anya, mmetụta ọjọọ na sistemụ ụjọ etiti).

Ime na lactation

Emebeghi nchekwa nke nchịkwa nke moxifloxacin n'oge afọ ime, yabụ ejiri contraindicated ka eji ya. A mara ihe mmebi mmebi mmebi na ụmụaka ndị butere ụfọdụ quinolones, mana achọpụtaghị ihe a na nwa ebu n’afọ mgbe Avelox na-emeso ụmụ nwanyị dị ime.

Ihe omumu anumanu gosiputara na okike omumu nke moxifloxacin. N'ihe banyere mmadụ, ihe ize ndụ nke Avelox ka aghọtachaghị.

Moxifloxacin, dị ka quinolones ndị ọzọ, na-akpasu mmebi emebi na oke uto nke nkwonkwo buru ibu na anụmanụ a mụrụ tupu oge ọmụmụ. Ọmụmụ preclinical gosiri na moxifloxacin, na obere mkpụ, na-abanye n'ime mmiri ara. Ihe omuma banyere ojiji o jiri ndi oria n’oge a na-enye nwa ara, ya mere, ihe eji eme ya n’oge a na-enye nwa ara.

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Mbadamba mkpuchi nwere ike:

• Otu mbadamba 1 nwere moxifloxacin (n'ụdị hydrochloride) - 400 mg
  N’ime igbe 1 ọpịpị maka 5 ma ọ bụ 7 PC,, ma ọ bụ n’ime igbe abụọ blisters maka 5 pcs.

Ihe ngwakọta nke ngwugwu:

• Otu karama nwere moxifloxacin (n'ụdị hydrochloride) - 400 mg
  ihe ndi ozo: sodium chloride, sodium hydroxide, hydrochloric acid, mmiri d / na.
  Kalama 250 ml -1 n’ime igbe.

Ihe ngwakọta nke ngwugwu:

• Ngwugwu 1 nwere moxifloxacin (n'ụdị hydrochloride) - 400 mg
  ihe ndi ozo: sodium chloride, sodium hydroxide, hydrochloric acid, mmiri d / na.
  Akpa 250 ml - akpa polyolefin (1) - akpa rọba akpa na foil (12) na igbe.

Omume ọgwụ

Moxifloxacin bụ ọgwụ nje nke na-egbochi ọgwụ nje nke nwere ọtụtụ ụdị ọrụ nke usoro fluoroquinolone. Mmetụta nke ọgwụ nje na-akpata n'ihi mgbochi nke topoisomerases nke nje na nke II, nke na-eduga ná mmebi nke biosynthesis nke DNA nke sel microbial na, n'ihi ya, ọnwụ nke mkpụrụ ndụ microbial. Obere ihe nje nje na -echekarị nke ọgwụ ọgwụ na-adịkarị site na iji obere mkpokọta mgbochi ya.

Usoro ndị na-eduga na mmepe nke iguzogide penisiliniins, cephalosporins, aminoglycosides, macrolides na tetracyclines anaghị emebi ọrụ antibacterial nke moxifloxacin.Onweghi nguzogide n'etiti otu ndia nke ogwu nje na moxifloxacin. Ruo ugbu a, enwebeghịkwa ikpe metụtara mgbochi plasmid. Oge mmepe nke nguzogide dị obere (10 7 - 10 10). Ndọgide moxifloxacin na-amalite nwayọ nwayọ site na mmụkọ ọ bụla. Ikwu ya ugboro ugboro nke moxifloxacin ka microorganisms na mkpokọta n'okpuru nke kacha nta inhibitory ịta (MIC) na-esonyere naanị ntakịrị ntakịrị na MIC. Ekwuru okwu nke nguzogide nguzogide na quinolones. Na agbanyeghị, ụfọdụ microorganisms gram-positive na anaerobic microorganisms na-eguzogide na quinolones ndị ọzọ ka nwere moxifloxacin.

Na vitro moxifloxacin na-arụ ọrụ megide ọtụtụ gram-na-adịghị mma na gram-microorganisms, anaerobes, nje na-eguzogide acid na ụdị atypical, dị ka Mycoplasma, Chlamidia, Legionella, yana nje ndị na-eguzogide ọgwụ mgbochi ß-lactam na ọgwụ mafolid.

Kedu ihe na-enyere Avelox aka?

Ihe kacha gosi na nhọpụta nke Avelox bụ ọnọdụ / ọrịa ndị a:

• Usoro ndị metụtara akpa ume na akụkụ akụkụ nke ENT,
• Ọrịa intraabdominal na urogenital,
• Ọrịa na - efe efe nke anụ ahụ dị nro na anụ ahụ.

A na-egosipụta ọrụ Avelox n'ihe metụtara ọtụtụ gram-positive na gram-microorganisms, nje na-eguzogide ọgwụ beta-lactam na ọgwụ nje macrolide, nje na-egbochi acid na ụdị microorganisms, yana nje nje anaerobic na-eguzogide ọgwụ.

Ime

Emebeghi nchekwa nke iji moxifloxacin n'oge ime emebeghi ya ma ejikwa ire. A kọwapụtara nsogbu mmebi mmebi a na -emeghachi na ụmụaka na-anata ụfọdụ quinolones, ka ọ dị, egosighi nsonaazụ nke nwa ebu n’afọ (mgbe nne ji ya n’oge ime).

Nnyocha ụmụ anụmanụ egosila na nsí ọmụmụ. Amaghị ihe mmadụ nwere ike isi mee ya.

Dị ka quinolones ndị ọzọ, moxifloxacin na-emebi oke uto nke nkwonkwo buru ibu na ụmụ anụmanụ akabeghị aka. Ọmụmụ preclinical achọpụtala na obere ego moxifloxacin na-apụta na mmiri ara ara. Achọpụtaghị data maka iji ya na ụmụ nwanyị n'oge a na-enye nwa. Yabụ, inye mọnụ nke moxifloxacin n'oge inye ara bụ ihe a machibidoro iwu.

Mkparịta ụka ọgwụ ọjọọ

Site na njikọta nke moxifloxacin na probenecid (ọnụnọ nke ụlọ ọrụ dị mkpa nke Avelox ka egosipụtaworo), atenolol, morphine, ranitidine, digoxin, itraconazole, ihe mgbakwunye calcium, glibenclamide, theophylline, ọgwụ mgbochi adịghị, cyclospor adịghị mkpa.

Site na iji Avelox na ọgwụ ọnụ jikọtara ọnụ na-emetụta ịgbatịkwu oge nke Qt, enwere ike ịhụ mmetụta mmụba nke ịgbatị oge Qt. Site na ngwakọta nke moxifloxacin na ọgwụ ndị yiri ya, a na-abawanye ihe ọghọm nke ịmalite ventricular arrhythmias, gụnyere polymorphic ventricular tachycardia (torsade de pointes).

Nchịkọta nke moxifloxacin na ọgwụ ndị na-eso nke na-emetụta mgbatị nke oge QT bụ nke a machiri:

• antihistamines (misolastine, astemizole, terfenadine),
• ọgwụ klaasị AA antiarrhythmic (ọgwụpyramides, hydroquinidine, quinidine, wdg),
• ọgwụ III nke antiarrhythmic (ibutilide, amiodarone, dofetilide, sotalol, wdg),
• antimalarials ọgwụ mgbochi, ọkachasị halofantrine, sparfloxacin, pentamidine, erythromycin (nchịkwa intravenous)
• tricyclic antidepressants,
• ihe mgbochi (suloprid, phenothiazine, haloperidol, sertindole, pimozide, wdg),
• ọzọ diphemanil, cisapride, bepridil, vincamine (nchịkwa intravenous).

Nlekọta nke Avelox n’otu oge ya na multivitamins, mineral na antacids nwere ike kpalite mmụcha nke moxifloxacin n’ihi nguzo nke chelate ogige na ọtụtụ cations nke bụ akụkụ nke ọgwụ ndị a. N'ihi nke a, ọkwa moxifloxacin na plasma ọbara nwere ike belata obere ka ọ dị mkpa. Ya mere, antiretroviral (dịka ọmụmaatụ, didanosine) na nkwadebe antacid na ọgwụ ndị ọzọ gụnyere aluminium ma ọ bụ magnesium, yana sucralfate na ọgwụ ndị ọzọ nwere zinc ma ọ bụ iron, ka akwadoro ka ewere ya opekata mpe 4 tupu ma ọ bụ 4 awa mgbe nchịkwa nke Avelox.

Site na ngwakọta nke Avelox na warfarin, oge prothrombin na usoro ndị ọzọ nke ịmịnye ọbara na-agbanwe agbanwe. N'ime ndị ọrịa gwọọ ọgwụ anticoagulants yana ọgwụ nje, a na-ahụta ikpe gbasara ike anticoagulant nke ọgwụ anticoagulant.

Ihe ndị dị n'ihe ize ndụ gụnyere ọnọdụ na afọ onye ọrịa, yana ọnụnọ ọrịa na-efe efe yana usoro mkpali. Agbanyeghi eziokwu na ekwuputaghi mmekorita nke moxifloxacin na warfarin rue ubochi, ndi oria na anara ogwu na ogwu a kwesiri ileba anya na INR mgbe niile, oburu na odi nkpa, bulie ma obu wedata uzo nke anticoagulants.

Digoxin na moxifloxacin ihe fọrọ nke nta ka ọ ghara emetụta ọgwụ ọgwụ nke ibe ha. Site na ntinye nke usoro ogwu nke Avelox ugboro ugboro, oke nke digoxin mụbara site na 30%. N'okwu a, ntakịrị itinye digoxin na uru nke mpaghara ahụ n'okpuru usoro ọgwụ pharmacokinetic "ịta - oge" ihe gbanwere.

N'iji onu ogugu nke moxifloxacin n’otu oge a na-a 400ụ ihe 400 mg na unyi na-arụ ọrụ, sistemụ bioavailability nke Avelox na-ebelata ihe kariri 80% n’ihi mgbochi nke mmụba ya. Bụrụ na ịdoụbiga ihe ọdoụdoụ ókè, ojiji nke carbon a gbanyere mkpọrọgwụ n'oge mmalite nke nnabata na-egbochi mmụba na mkpughepu sistem.

Ihe analogues nke Avelox di n’ime ihe ahu na aru oru bu ogwu ndia: Vigamox, Moximac, Moxin, Moxifloxacin, Moxifloxacin hydrochloride, Plevilox. Otu ụdị ọgwụ ọgwụ ahụ gụnyere: Abactal, Basigen, Gatispan, Geoflox, Zanocin, Xenaquin, Levoflox, Normax, Ofloxacin, Ciprofloxacin na ndị ọzọ.

Nyocha banyere Aveloks

Nyocha banyere Avelox nke ndị ọkachamara hapụrụ bụ arụmụka. Doctorsfọdụ ndị dọkịta na-ewere ya dị ka ọgwụ mgbochi siri ike ma dị oke mma nke na-enyere aka ịnagide ọrịa na-akpata ọrịa dịka chlamydia, pyelonephritis, flu, SARS, na E. coli. Ndị ọkachamara ndị ọzọ na-ekwu na ihe fọrọ nke nta ka ọ bụrụ nsonaazụ dị mma ọ bụla nke ọgwụgwọ, mana ha hụrụ ọtụtụ ọnụọgụ mmetụta.

A na-agwakọta echiche ndị ọrịa banyere Avelox. Ọtụtụ mmadụ na-ekwu ụdị mmeghachi omume ọjọọ ndị dị ka mbelata agụụ na ọgbụgbọ. Agbanyeghị, ọtụtụ ndị ọrịa na-ewere ya dị ka ọgwụ siri ike na-adị irè.

Ngwakọta na ụdị ntọhapụ

Avelox dị n'ụdị mbadamba na ihe ngwọta maka infusion (abụghị maka injection). Mara onwe gị na ihe mejupụtara, nkọwa na nkọwa dị mkpirikpi nke ọgwụ:

Pink, matte, oblong, ihe mkpuchi.

Oyi na acha odo odo-acha akwụkwọ ndụ mmiri mmiri.

Concentta moxifloxacin, mg

400 maka otu karama

Titanium dioxide, celclose microcrystalline, macrogol, shịum croscarmellose, iron ironide, lactose monohydrate, hypromellose

Mmiri, sodium chloride, hydrochloric acid, sodium hydroxide solution.

Blisters maka 5 ma ọ bụ 7 PC., Mwepu nke 1 ma ọ bụ 2 blisters.

250 ml vials ma ọ bụ arịa.

Usoro onunu ogwu na nhazi

Ndị dọkịta na-edenyekarị Avelox maka angina, etuto ahụ, ka oyi baa, n'ihi mmetụta antibacterial, ọgwụ ahụ na-egbu ndị na-akpata ọrịa ahụ ma belata mbufụt. Ofzọ itinye ya n'ọrụ, usoro onunu ogwu ya na oge ọ na-agwọ ọrịa dabere na ụdị, ogo ọrịa yana ụdị ọgwụ a. A na-ewere mbadamba okwu ọnụ, ihe ngwọta bụ parenteral, n'ụdị infusions.

Akara nke dị n’ime mbadamba nkume na-ewere ọnụ na 400 mg 1 oge / ụbọchị. Mpekere ndị ahụ anaghị ata ata, were mmiri mmiri hichaa ya, n'agbanyeghị nri. N’oge agadi, usoro onunu a agbanweghi. Oge ọgwụgwọ ọ dabere na ọrịa a:

Ọ na-emeso ya na ụbọchị

Anwụ nke bronchitis na-adịghị ala ala

Ahụhụ na-efe efe nke ime obodo batara site na ụzọ nke izipu Avelox

Ngwunye infusion

Maka iji intravenous, a na-ezube otu ihe ngwọta nke otu aha ya na mgC mg ugboro anọ / ụbọchị. Ọgwụ ọjọọ na-adịru ụbọchị 21. Site na pneumonia nke obodo nabatara, usoro ọgwụgwọ na-anọ ụbọchị 7-14, yana ọrịa metụtara - 7-21 ụbọchị, na ọrịa intra-abdominal - 5-14 ụbọchị. Maka ndị agadi na ndị ọrịa nwere ọrụ imeju, ọgwụ ha anaghị agbanwe agbanwe.

A na-achịkwa azịza ya nye ọbara ruo otu awa. Enwere ike iji ọgwụ ahụ gwuo ya na mmiri, ihe ngwọta Ringer, sodium chloride, dextrose ma ọ bụ xylitol. Naanị ihe doro anya a na-ewebata n’enweghị nsogbu, sedimenti. Dil gwachaa ya na ihe ndị na-egbu ya, ọgwụ ahụ kwụsiri ike ụbọchị ahụ dum, ọ bụrụhaala na echekwara ya n'ụlọ okpomọkụ.

N’oge ime ime

Emebeghi nchekwa nke iji moxifloxacin n'oge ime emebeghị, yabụ ojiji ejiri contraindicated. Ihe omumu emere banyere oke gosiri ihe omuma omumu. N'ime anụmanụ, Moxifloxacin na-emebi oke uto nke nkwonkwo akwara, nke a na-arapụta na mmiri ara, ya mere a na-egbochi ọgwụgwọ ị withụ ara.

Na nwata

Enweghi ike iji nzu nke nwata na etolite etolite n’agbata afo iri na asatọ. Ejikọtara nke a na oke ihe egwu ọrụ yana nkwonkwo akwara na akwara. Nkpughepu anya nke ukwuu na ọgwụ nje nwere ike ibute nsị, mmepe nke rashes, ịda mba na nkụda mmụọ nke sistemụ akwara. Nke a dị oke egwu na nwata na n'etiti ụmụ akwụkwọ.

Avelox na mmanya

Iji zere ihe ize ndụ nke nsogbu ọrịa imeju, maka oge ịgwọ ọrịa Avelox, ị ga-ajụ ị toụ mmanya na-aba n'anya ma ọ bụ ọgwụ ọjọọ. Mmanya na-aba n’anya na-emebi ahụ mmadụ, na-akpata ị causesụbiga ya ókè na egbu egbu. Ethanol belata ịdị irè nke ọgwụ ahụ, na-eduga mmeghachi omume ọjọọ. Inwere ike ịmaliteghachi ị were ya otu ọnwa mgbe ngwụcha ọgwụgwọ gasịrị.

Usoro ire na ebe nchekwa

A na-ere Avelox site na ndenye ọgwụ, echekwara ya na okpomọkụ ruo ogo 25 maka mbadamba na ogo 15-30 maka ngwọta. Ndụ nchekwa nke mbadamba nkume na vials nke ihe ngwọta bụ afọ ise, ihe ngwọta n'ime arịa bụ afọ atọ.

A na-ekwu maka ihe omimi nke nwere otu ihe eji arụ ọrụ ma jiri ihe ọzọ dochie anya ya, mana otu usoro ahụ nwere, a na-ezo aka Aloksks analogues. Ọgwụ antimicrobial analogues:

• Aquamox - ihe omimi dabere na moxifloxacin,
• Moxifluor bu ogwu banyere otutu ogwu ajuju,
• Megaflox - mbadamba nkume nwere otu ihe eji arụ ọrụ.
• Hainemoks - nkwadebe mbadamba ihe, akara akazi,
• Moxifloxacin bụ ọgwụ ọgwụ ewu ewu.

Ntụziaka maka ojiji (Usoro na usoro onunu ogwu)

A na-ewere mbadamba na-enweghị ata ata ma ọ bụ nkewa, n'agbanyeghị nri.

Dabere na ntuziaka maka Avelox 400 mg, maka ndị okenye, usoro a na-eme kwa ụbọchị bụ otu mbadamba ma ọ bụ 400 mg nke ọgwụ nje.

Onye dibia bekee ga -eche oge ọ ga-aha ya, ya na usoro nlekọta ya, dabere ogo ọrịa ahụ, arụmọrụ ya na ịmara onye ọrịa ahụ.

Dịka iwu, na mmalite ọgwụgwọ, a na-enye ọgwụ ọgwụ na injections, mgbe ahụ, mgbe mmalite nke ndozi, enwere ike ịkọwa mbadamba mbadamba.

Site na iwe ala alaọla kọpa usoro ọgwụgwọ ya na ọgwụ ahụ bụ ụbọchị 5. Na oyi baa - site na 7 (injections) ruo ụbọchị iri.

Na nnukwu sinusitis yana ọrịa akpukpọ anụ ahụ na anụ ahụ, oge nchịkwa ọgwụ mgbochi bụ otu izu.

N’ibute ọrịa nje n’akwara pelvic, ihe a na-eme bụ izu abụọ.

Ọ bụrụ na ọrịa akpukpo anụ arụ dị mgbagwoju anya na anụ ahụ, a na-eme ọgwụgwọ ahụ site na ụkwụ ma werekwa ụbọchị ise rue izu abụọ.

N'ime ndị nwere nsogbu gbasara akụrụngwa yana ọrịa ịba, ndị agadi, yana agbụrụ dị iche iche, anaghị eme mgbanwe ọ bụla.

Ntuziaka maka iji Avelox maka ịgba ntụtụ

Jiri naanị ihe doro anya, na-enweghị mkpali ma ọ bụ igwe ojii.

A na-achịkwa ọgwụ ahụ ruo ogologo oge, maka nkeji 60, ọbụlagodi na-agbaghị. Ọzọkwa, a na-agwakọta ọgwụ nje Ihe nkwụnye T jiri mmiri gbanye ya ngwọta sodium chloride(0.9% ma ọ bụ 1M), ngwọta dextrose (5%, 10%, 40%), ngwọta xylitol 20%, azịza ringer. Enwere ike idobe ngwakọta a kwadebere na ụlọ ahụ maka awa 24.

N'ime sirinji ma ọ bụ mpekere, ndị ọzọ anaghị agwakọta.

Mmekorita

Ọ pụtara na atenolol, theophylline, nhazi nke calcium, ranitidine, ọgwụ mgbochi, intraconazole, morphine, glibenclamide, digoxin, warfarin, probenecid.

Agbanyeghị, mgbe ejikọtara ya na anticoagulants na-apụtaghị ìhè kwesịrị ịtụle ma na-elele oge ụfọdụ INRmezie ọgwụ ogwu ahụ n'ụzọ ziri ezi.

Mgbe ejikọtara ya na antacids, multivitamins na ihe ndi diri mineral cheta mgbagwoju anya na polyvalent cations, ịta nke ọgwụ nje na ọbara na-ebelata. N'akụkụ a, oge dị n'etiti awa 4 n'etiti ị theụ ọgwụ ndị ahụ kwesịrị ịhụ.

Ọ bụrụ na ijikọ ọgwụ na carbon ndị ọrụ emegharị ma ọ bụ ndị ọzọ enterosorbents, mgbe ahụ, a na-ebelata bioavailability nke ọgwụ ahụ (ihe dịka 80%). Site na nchịkwa ọgbụgba ọbara, ọnụ ọgụgụ a ruru 20%.

Edozi nsogbu maka infusion na 10% na sodium chloride, sodium hydrogencarbonate 4.2% na 8.4%.

Analogs nke Aveloks

Ihe kacha mma analogues nke Avelox: Moxifloxacin-Farmex, Moxifloxacin, Moxifluor, Moflox, Moxifloxacin-Kredofarm, Maxicin, Moxifluor 400, Moxin, Tevalox, Mofloxin Lupine.