Ntụziaka

.De n’adwene sii A na-eji ya agwọ ọrịa nke microorganisms maara na ọgwụ ahụ:
- obere ala na-efe efe na-efe efe: nnukwu bronchitis na njọ nke bronchitis na-adịghị ala ala, oyi baa
- Ọrịa urinary na-efe efe: pyelonephritis, cystitis, urethritis na prostatitis
- ofufe ọrịa nke anụ ahụ na anụ ahụ dị nro,
- afọ ime: peritonitis, ọrịa biliary tract,
- ọrịa gynecological,
ọrịa mbufụt
- ọgwụgwọ ala maka febrile neutropenia,
- ọrịa nje meningitis.

Ndị ọchịchị ọgwụ / ndị na-ahụ maka ihe ndị dị ndụ na ihe ndị dị ndụ

Nchịkọta nke Cefepim prigny nke enzymes nke nje klitini і ma д dị iche iche nke nje bacteria na-akpata na gram na-adịghị mma. Cephepium bụ viscous nke ukwuu na hydrolysis nke b-lactamase, a na-ahụ obere asọmpi n'ihu ọnụnọ nke b-lactamase, nke mkpụrụ ndụ chromosome kpuchiri, yana shvidko banye n’ime mkpụrụ ndụ nje gram.

Tsefepіm ọrụ agụmakwụkwọ nke microorganisms dị:

grampositive aerobi:Staphylococcus aureus nke ahụ Staphylococcus epidermidis (gụnyere šx shtami, scho Production b-lactamase), іshi shti stafіlokokіv, jikọtara S. hominis, S. saprophyticus, pyogenes nke Streptococcus (otu A streptococci), Ike komboliscoccus (Streptococcus otu B), Ahụ ike na-efe efe (tinyere shtami site na ụdị etiti ruo na penisilini - ụdị IPC 0.1 ruo 1 μg / ml), b-hemolytic streptococci (otu C, G, F), S. bovis (otu D), streptococci otu Idmụ nje. (Bіlshіst straіnt enterokokіv, ọmụmaatụ: Enterecoccus faecalis, staphylococcus, na-eguzogide ọgwụ nke methicillin, na-eguzogide ọgwụ mgbochi cephalosporin ka ukwuu, gụnyere cefepim)

Aerobi dị mma na-adịghị mma:Pseudomonas spp , gụnyere P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella spp., gụnyereK. poniaoniae, K. oxytoca, K. ozaenae, Enterobacter spp., gụnyere E. cloacae, E. aerogenes, E. agolomeratus, E. sizakii, Proteus spp., gụnyere P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. anitratus lwoffi), Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp., gụnyere C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (tinyere shtami, imepụta beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis) (gụnyere shtami, imepụta b-lactamase), Neisseria gonorrhoeae (gụnyere shtami, imepụta b-lactamase), Nessera meningitidis, Pantoea agglomerans (vіdomiy yak Enterobacter agglomerans), Providencia spp. (gụnyereP. rettgeri, P. stuartii), Salmonella spp., Serratia (gụnyere S. marcescens, S. liquefaciens), Shigella spp., Yersinia enterocolitica.

(Cefepim anaghị arụ ọrụ Xanthomonas maltophilia na Pseudomonas maltophilia),

anaerobi:Bacteroides spp., B. melaninogenicus, dina ala Bacteroides, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp.

(Cefepim anaghị arụ ọrụ Bacteroides fragilis і Clostridium mgbasa).

Nchịkọta nkezi nke cefepima na plasma site na mgbe emepere mgbe nchịkwa intramuscular otu oge pụtara na tebụl.

Nlebara anya plasma na plasma (μg / ml) na mgbochi (ntugbu) na ntinye (ime)

Ngwongwo ogwu

Cepepime na-egbochi njikọ nke nje bacteria na mgbidi nje ma nwee ụdị ọrụ dị iche iche na-emetụta ụdị gram iche-gram na nke na-adịghị mma gram. Cepepime na-eguzogide hydrolysis site na ọtụtụ b-lactamases ma nwee obere ala maka b-lactamases nke mkpụrụ ndụ chromosomal kpuchiri, ma na-abanye ngwa ngwa mkpụrụ ndụ nje gram-na-adịghị mma.

Cepepime na-arụ ọrụ megide microorganisms ndị a:

gram-ọma aerobesStaphylococcus aureus na Staphylococcus epidermidis ( tinyere ụdọ ha na - emepụta b-lactamase) ụdị staphylococci ndị ọzọ, gụnyere S. hominis, S. saprophyticus, pyogenes nke Streptococcus (Otu komputa A na-akpọ Streptococcus A), Ike komboliscoccus (Streptococcus otu B), Ahụ ike na-efe efe (tinyere ụdọ nwere nguzogide na penicillin - MIC site na 0.1 ruo 1 μg / ml), b-hemolytic streptococci (otu C, G, F), S. bovis (otu D), streptococci otu Idmụ nje . (Ọtụtụ ụdị nke enterococci, dịka ọmụmaatụ Enterecoccus faecalis, na staphylococci methicillin na-eguzogide ọgwụ mgbochi cephalosporin, gụnyere cefepime)

gram ọjọọ aerobesPseudomonas spp , gụnyere P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella spp., gụnyere K. poniaoniae, K. oxytoca, K. ozaenae, Enterobacter spp., gụnyere E. cloacae, E. aerogenes, E. agolomeratus, E. sizakii, Proteus spp., gụnyere P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. Anitratus lwoffi ) , Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp., gụnyere C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (gụnyere ụdị arụpụtara beta-lactamase) H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis ) (gụnyere b-lactamase na-emepụta ụdị) Neisseria gonorrhoeae (gụnyere nje ndị na-emepụta b-lactamase) Nessera meningitidis, Pantoea agglomerans (nke a maara dị ka agglomerans Enterobacter) Nyeencia spp. (gụnyere P. rettgeri, P. stuartii ) Salmonella spp., Serratia (gụnyere S. marcescens , S. liquefaciens) Shigella spp., Yersinia enterocolitica .

(Oge emehe adịghị arụ ọrụ gbasara ọtụtụ ụdị Xanthomonas maltophilia na Pseudomonas maltophilia )

anaerobes:Bacteroides spp., B. melaninogenicus metụtara Bacteroides , Clostridium perfringens, Fusobacterium spp., Mobiluncus spp ., Peptostreptococcus spp., Veillonella spp.

(Oge ememme adịghị arụ ọrụ site na Bacteroides fragilis na Clostridium mgbasa ).

Nchịkọta plasma nke oge elekere n’oge dị iche iche mgbe egochara otu intramuscular na tebụl.

Plasma cefepime concentrations (mcg / ml) na ntinye (i / v) na nchịkwa intramuscular (m / m)

Ofzọ nke ngwa

akwara. Maka nchịkwa jet, a na-agwakọta otu ọgwụ nke ọgwụ na 5 ma ọ bụ 10 ml nke isotonic sodium chloride solution, 5% gllu mmiri ma ọ bụ mmiri na-enweghị mmiri maka ntụtụ ma jiri nwayọ gboo 3 - 5.
Site na mkpocha ọbara intravenous nke ọgwụ, 500 ma ọ bụ 1000 mg dilis na 100 - 250 ml nke isotonic sodium chloride solution ma ọ bụ 5% gluuze, a na-arụ ọrụ nchịkwa ahụ ọ dịkarịa ala minit 30.

Maka ndi okenye.
Ọrịa ọnya na-efe efe, dị nwayọ ruo obere: 500 mg - 1 g intravenly ma ọ bụ intramuscularly kwa elekere 12:00.
Ọrịa, dị nwayọ rue 1 g intravenia ma ọ bụ intramuscularly kwa elekere 12:00
Ọrịa siri ike: 2 g kwa elekere 12:00 ọ bụla
Oria di egwu ma di ndu nke 2 g kwa 8h obula
N'ime ndị ọrịa nwere arụmọrụ gbasara akụrụngwa (nwechara mkpụrụ osisi 60 2 g ọ bụla 8:00 2 g kwa 12:00 1 g ọ bụla 12:00 1 g ọ bụla 12:00
30 - 50 mmeghari onyonyo dabere na nhazi nke creatinine
2 g kwa elekere 12:00 2 g kwa awa 24 ọ bụla 1 g awa 24 ọ bụla 500 mg kwa awa 24
11 - 29 2 g kwa awa 24 ọ bụla 1 g awa 24 ọ bụla 500 mg kwa awa 24 na 500 mg kwa awa 24

Ndị ọchịchị ọgwụ.

Nchịkọta nke Cefepim prigny nke enzymes nke nje klitini і ma д dị iche iche nke nje bacteria na-akpata na gram na-adịghị mma. Cephepium bụ viscous nke ukwuu na hydrolysis nke b-lactamase, enwere asọmpi pere mpe maka b-lactamase, mkpụrụ ndụ chromosome kpuchiri ya, ọ na-ekwukarị ya nke ọma na mkpụrụ ndụ nje gram.

Tsefepіm ọrụ agụmakwụkwọ nke microorganisms dị:

grampositive aerobi:Staphylococcus aureus nke ahụ Staiderlococcus epidermidis (Gụnyere шхні shtami, scho mepụta b-lactamase), інші shtami stafіlokokіv, gụnyere S. hominis, S. saprophyticus, pyogenes nke Streptococcus (otu A streptococci), Ike komboliscoccus (Streptococcus otu B), Ahụ ike na-efe efe (tinyere ihe eji agbatị etiti ruo penisilini - ntinye nke kacha nta nke 0.1 ruo 1 μg / ml), b-hemolitic streptococci (otu C, G, F), S. bovis (otu D), streptococci otu Idmụ nje. (Bіlshіst strainіnterokokіv, ọmụmaatụ Enterecoccus faecalis, ст staphylococci na-eguzogide ọgwụ na methicillin, na-eguzogide ọgwụ mgbochi cephalosporin ka ukwuu, gụnyere cefepim)

Aerobi dị mma na-adịghị mma:Pseudomonasspp, gụnyere P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiellaspp., gụnyere K. poniaoniae, K. oxytoca, K. ozaenae, Enterobacter spp., gụnyere E. cloacae, E. aerogenes, E.agolomeratus, E. sizakii, Proteusspp., gụnyere P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (wedata.anitratus lwoffi), Aeromonas hydrophila, Capnocytophagaspp., Citrobacterspp., gụnyere C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (tinyere shtami, imepụta beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis (Branhamella catarrhalis) (gụnyere shtami, scho mepụtara b-lactamase), Neisseria gonorrhoeae (gụnyere shtami, scho mepụtara b-lactamase), Ndesserameningitidis, Pantoea agglomerans ( vidomy yak Enterobacter agglomerans), Providencia spp. (gụnyere P. rettgeri, P. stuartii), Salmonella spp., Serratia (gụnyere S. marcescens, S. liquefaciens), Shigellaspp., Yersinia enterocolitica.

(Cefepim anaghị arụ ọrụ Xanthomonas maltophilia і Pseudomonas maltophilia),

anaerobi:Bacteroides spp. , B. melaninogenicus, dina ala Bacteroides, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp. (Cefepim anaghị arụ ọrụ Bacteroides fragilis і Clostridium mgbasa).

Nchịkọta nkezi nke cefepima na plasma site na mgbe emepere mgbe nchịkwa intramuscular otu oge pụtara na tebụl.

Plasma na-etinye uche na plasma (μg / ml) na ọnya (ọgbụgba) na akwara ime (intravenous)

Sich, zhovchі, peritoneal ridin, mucous secretion nke ọwara akwara, sputum, prostate, appendices na zhovchnomu mikhury nwekwara usoro ọgwụgwọ nke cefepima.

Na etiti oge napivvidendenny cefepіmu na anụ ahụ dị ihe dị ka afọ 2. N'ime ahụike mmadụ, n'ihi nke a, a na-edozi dos dị elu ruo 2 g n'ime mmadụ na afọ 8, na-adigide ụbọchị 9, mmụba nke ọgwụ ahụ na ahụ adịghị ebuli ya.

A na-eme ka Cepepime ka ọ bụrụ N-methylpyrrolidine, a na-eme ka ọ bụrụ metabolized N-methylpyrolidine ngwa ngwa. N'etiti zagalny cl_rens ga-abụ 120 ml / hv. You nwere ike ịhụ ole ị ga - ahụ karịa Vinyatkovo maka mahogany nke usoro ndị a na - eme mgbe niile - isi bụ ya bụ okpu klọọkụ glomerular (nkenke nirkovy bụ 110 ml / hv). Ihe dị ka 85% nke wepụrụ oge eji emechi emechi enweghị akwụkwọ, 1% N-methylpyrolidine, ihe dị ka 6.8% nke N-methylpyrolidine oxide, na ihe dị ka 2.5% nke oge Cefepime gosipụtara na ikpe ahụ. Ofda oge ekwumekwu na plasma ọbara na-aghọ ihe na-erughị 19% ma ghara ịgha ụgha na ịrationụ ọgwụ ahụ na ọbara.

Maka ndị ọrịa nwere echiche iri isii na isii maka ọrụ ha, ọ dịghị ha mkpa imeghari ọ̀gaghị ọgwụ ahụ na cefepim, ma nha nzere nickel na-anọghị nke ndị na-eto eto.

Nkwupụta gara aga, nke e mere maka ọdịmma nke ndị nwere nsogbu ahụike kachasị njọ, gosipụtara oge nzukọ kachasị. N'etiti oge, dịka ọmụmaatụ, na ndị ọrịa nwere nnukwu ọrụ ọfụma, ọ dị m mkpa ịchọ obere ụzọ ya na ọrịa akwara, be afọ iri na atọ nwere ọrịa metụtara ọrịa na afọ iri na itoolu na mgba okpo iku ume.

A maghị ọgwụ pharmacokinetics nke cefepim na ọrịa na-emebi emebi nke imeju bụ mucoviscidosis. Corriguvanny dozi maka ụdị ọrịa adịghị mkpa.

N'oge nchịkwa, dose nke oge ehihie 50 mg / n'arọ nke anụ ahụ ruo afọ 12 abụghị ọnụọgụ; akpụkpọ anụ afọ 8.

Klіnіchnі njirimara.

Ofufe Ọrịa, n'ihi uche ya na ọgwụ mikroflora:

- ụmụ nwanyị dichalny, gụnyere oyi baa, ụkwara ume ọkụ,

- Shkіri na pidshkіrno klіtkovini,

- Іntraabdomіnalі інфекції, gụnyere ọnụọgụ nke peritonitis na інфекції жовчовивідних хлавів,

Nnukwu ọgwụgwọ вvorich iz iz neutropenichnoy garyachkoy.

Mgbochi nke ime ihe mberede na mpaghara ahụike.

- Інфекції secchivividnyh ndị na-alụ nwanyị, na mgbakwunye na pyonephritis,

- ozi shkіri na pidshkіrno klіtkovini,

- ọgwụgwọ ọrịa ọgwụ оirиvorich iz ot neutropenichesky hotachka,

Njikọ ya na taabụ kacha mkpa ma hụ mgbanwe.

Zastosovuchi oke aminoglycosides ozugbo na Likesky aghụghọ Extentsef, jiri nkwanye ugwu dochie ọrụ nke nickel site na ikike nke nephrotoxicity na ototoxicity nke ọgwụ nje aminoglycoside. E gosipụtara Nephrotoxicity maka njikọta nke cephalosporins nke imekọ ọbara, dịka furosemide.

Ntinye ndọtị 1 na 40 mg / ml site na uru parenteral ndị a: 0.9% slorum chloride chloride maka 5%, shuga glucose 10% maka 6%, 6% sodium chloride maka 5%, 5% glucose na 0.9% sodium chloride maka inoculation, ule Ringer maka lactate na 5% glucose maka inoculation.

Nweghị ike inye ọgwụ ọgwụ ndị dị mkpa ozugbo ị zụrụ ọgwụ ahụ, zụta ọgwụ Extentsef (yana ọgwụ mgbochi b-lactam kachasị dị irè), anaghị achịkwa metronidazole, vancomycin, sulfate, na citamic acid ozugbo. N'oge a na -echepụta ọgwụ Extentsef na ọgwụ ọgwụ etinyere, banye n’akpukpo ahu okremo.

Enyere nsonaazụ ule nyocha.

Ọnọdụ nke oge anwụrụ nwere ike ibute mmeghachi omume hibnopositive maka glucose na ọnụnọ nke Benedict reagent. A na-atụ aro ka ọ nwalee maka glucose, dabere na mmeghachi omume enzymatic nke oxidation glucose.

Atụmatụ zastosuvannya.

Maka ndị ọrịa nwere nnukwu ihe egwu na-efe efe (dịka ọmụmaatụ, maka ndị ọrịa na ụmụaka, ha ejirila ọrụ belata mmịnye nke ụbụrụ nwa ehi ahụ, a na-egosikwa naanị obere ọgwụ dị egwu maka nke a).

Ọ dị mkpa ịmata ndị pụtara na mbụ na mmeghachi omume nhụsianya nke ụdị hypertrophy na-abụghị nzuzo na cefepime, cephalosporini, penicillin, na ọgwụ inoculant antibacterial. Ọgwụ nje varto iji jiri nlezianya mee ememe anyị niile na-eto ụdị ọ bụla nke nfụkasị, ọkachasị na nkwadebe ọgwụ. Ọ bụrụ na enwere mmeghachi ahụ nfụkasị ahụ, ọgwụ ahụ kwesịrị idozi. Mmeghachi omume siri ike nke ụdị ịba ọcha n'anya nwere ike ịdị adrenaline na ụdị ọgwụgwọ dị ala.

Zastosovuvati na ichebe ndị ọrịa sez nke ọdịdọ ahịhịa (nke zoro n’akụkọ ihe mere eme), kachasị gụọ.

N'ihe banyere stasis, ihe fọrọ nke nta ka ọ bụrụ ọgwụ nje niile nke nje pseudomembranous dịgasị iche na-adịcha iche. Ọ dị mkpa ka ị attentionaa ntị na ịzụlite ọrịa na-efe efe n'oge ọgwụgwọ ụmụaka na ụmụaka site na ọgwụ Ekstentsef Dosledzhennya iji taa ndị nwere nsị nwere ike ịmepụta Clostridium mgbasa,, bụ isi ihe na - akpata ọgwụ mgbochi obodo. Iji chọpụta ọrịa pseudomembranous colitis, ọ dị mkpa ịkụnye nleta ọgwụgwọ. Ọrịa pseudomembranous nke ọrịa siri ike nwere ike ịpụta ìhè mgbe edoziri nkwadebe ahụ. Na vipadok, ọ dị mkpa ka ejiri nlezianya nyochaa ọnụ ọgụgụ ndị nwere ili na usoro siri ike, mkpa maka ibu ọnụ na electrolyte, kachasị mma maka ibu ọnụ na ibu ọnụ ọgwụ ọgwụ nje. Clostridium mgbasa.

Maka ndị ọrịa nwere ọrụ arụmọrụ (ịrụ ọrụ nke creatinine ≤ 60 ml / hv), a ghaghị idozi dose nke cefepime site na ịkwụ ụgwọ maka ọgwụ ọjọọ. N'ime ụbọchị ndị ahụ, mgbe enwere oke ọgwụ ịda ogbenye na ọrịa na-arịa ọrịa, ha nwekwara ike ịkwụsị ọrụ nirk, anyị nwekwara ike ịbawanye ikpughe ha. Site na oke onodu iwepughi oke, mbelata onwonye ya na oru ya, ogo ya bu oria ya na ntinye uche nke microorganism. Na usoro nke ilere azụmaahịa, ọgwụ akwụsịla inwe mmerụ ahụ dị njọ, ha abụrụla ihe iyi egwu nye ndụ, ma ọ bụ ejaculations na-egbu egbu: encephalopathy (mwepu ikpe, ọnwụ nke nsụhọ, enweghị nlebara anya) Ọtụtụ ndị vipadas bụ ndị ọrịa nwere ọrụ mmerụaka nsogbu nke nirok, dịka dozosovuvili doses nke cefepim, mana ọ na-atụ aro imegharị ya. A katọrọ mkpagbu Inkoli na mmemme ahụ, yakimiruyut dosages, scorched si urahuvannyam funktsії nirok. N'ọtụtụ oge, e jikọtara ihe mgbaàmà nke nephrotoxicity na werewolves, ọ nweghịkwa akara ọ bụla na -agabiga na / ma ọ bụ ịkwụsị hemodialysis.

Enweghị obere mkpa maka nkwalite ma ọ bụrụ na enwere ntakịrị ihe akaebe nke ịkwụsị ọkụ ma ọ bụrụ na mmụba ọ bụla na ọrịa nje n'ọdịnihu. Trivale mkpọchi cefepіmu (ọgwụ nje yak іshih) nwere ike ibute mmepe nke superinfection. Ọ dị mkpa iji duzie ntugharị ugboro ugboro ka patsenta. N'oge mmepe nke oke ibu, ịkwesịrị ịpụ na nleta ndị kachasị ọhụrụ gị.

Bagato cephalosporins, gụnyere cefepim, metụtara ọrụ belata prothrombin.Tupu ijikọ, ịchọrọ ịbanye ndị ọrịa yana ọrụ ndị gbajiri nke stovu, mana ụmụ nwoke, ụmụaka, ụmụaka na-atamu ntamu, ọzọkwa, ha agabigala usoro ọgwụgwọ na-enweghị isi. Ọ dị mkpa ịchịkwa prothrombin n'ime ndị ọrịa nwere otu yana ihe ama ama dị mkpa nke K. K.

N'oge mkpọchi, cefepim nwere ike ịdị mma ma ọ bụghị nke ọma site na ule Coombs kpọmkwem. N'oge usoro hematologic ma ọ bụ mmịnye ọbara, mgbe emere ụdị ọbara egosipụtara n'ụzọ dị oke mma, ma ọ bụrụ na emere antiglobulin ule, mana ejiri Coombs mee ihe maka ndị ọhụrụ, a kagburu ndị nne ọgwụ nje nke cephalosporins, anyị nwere ike inweta ezigbo nnwale nsonaazụ.

A zulitere Bulo, nke mere na ọgwụ L-arginine na-enye glucose metabolism ozugbo n'otu oge n'ọbara na-eji ọgwụ siri ike, ihe ruru ugboro iri atọ na atọ karịa oge ekwesi. Mmetụta na obere doses maka afọ ọhụrụ.

Mgbe zasosuvannі lіdokainu yak rozniknika slіd vrakhovuvati іnformatsіy na bezpeki lіdokainu.

Zastosuvannya n'oge vaginosti abo nke ara.

Ọdịmma na njiri mara nke ọma na akụkụ ụmụ nwanyị adịbeghị, yabụ Extres nwere ike ịnwe ọkwa nke otu dị ka nne, ma ọ bụrụ na agbachapụrụ ntutu isi nne iji nyefee ikike nke nwa ebu n’afọ.

Cefepim na mmiri ịsa ahụ pere mpe, nmịpụta ara ara ka ọ bụ mmiri ara, nke ahụ bụ oge awa nke afọ ara ha.

Ahụike iji jide ọsọ nke mmeghachi omume mgbe ụgbọ ala nke cheruvannі na usoro ndị ọzọ.

Ihe dị na bofepim maka ọsọ nke mmeghachi omume bụrụ nke ụgbọ njem cheruvanny, n'ihi na robots ahụ esoghị usoro ndị kachasị ọhụrụ, na-agbanyeghị, were nwanne m nsọpụrụ, mana mgbe otu elekere gachara ọgwụ ahụ, agaghị m enwe ike imeghachi omume site n'akụkụ sistemụ ụjọ.

Sposib zososuvannya na dosi.

Zvichayna dose maka nká ghọrọ 1 g, nke a na-elekọta n'ime ma ọ bụ n'ime ya na etiti afọ 12. Zvichayna obere nke ngosipụta - ụbọchị 7–10, ọrịa siri ike nwere ike iri oke karịa.

Dosuvannya m shlyakh uvdennya var_yuyut fallowingly n'ụzọ dị nro microorganism, nlekọta ahụ ike, larịị nke ọrịa, yana arụ ọrụ nke ọrịa nikor. Aro nke kachasi ike nke ogwu Extentsef maka iwebata n ’okpokoro.

Dнфекції сечових ххіів mfeї na ibu arọ

500 mg - 1 g n'ime ime, mana ọnya anụ ahụ

Кціїнші інфекції ibu na-adịghị arọ

1 g n'ime, ma n'ime