08 May, 2024
    Ọgwụgwọ na mgbochi

    Augmentin® (Augmentin®)

    Augmentin bụ ọgwụ dị mgbagwoju anya site na otu ọgwụ nje nwere ọtụtụ mmetụta, nke gụnyere amoxicillin na clavulanic acid.

    Isi ihe dị na mbadamba nkume ahụ bụ amoxicillin, nke bụ ọgwụ nje nke nwere ụdị ngosipụta dị iche iche nke mbute semisynthetic sitere, nke na-egosipụta oke ọgwụgwọ ọgwụgwọ megide ọtụtụ gram-positive na gram-microorganisms. Emebiwo ọgwụ ahụ site na beta-lactamases, yabụ, ọgwụ edebere na ihe a nọ n'ọrụ enyeghị iwu maka mbibi nke nje microgenganisms nke na-emepụta beta-lactamases.

    Clavulanic acid, nke bụ akụkụ nke mbadamba ọgwụ a, bụ ọgwụ beta-lactam nke nwere ike ibibi ma ọ bụ kwụsị ọrụ nke beta-lactamases na enzymes ndị ọzọ mepụtara site na microorganisms pathogenic, nke n’aka nke na-egosi nguzogide na penicillin otu ọgwụ na cephalosporins.

    Aclọ clavulanic acid dị na mbadamba ihe ahụ na-echebe amoxicillin site na mbibi na-egbu egbu nke beta-lactamases nke microorganisms mepụtara, si otú a na-enye aka n'ịbawanye akụrụngwa nke ọgwụ nje. N'ihi ngwa a, Augmentin nwere ike imebi mmetụta microorganisms pathogenic nke na-eguzogide ọgwụ penicillin nke ọgwụ na cephalosporins.

    Kedu microorganisms nke ọgwụ a na-emetụta?

    Mbadamba Augmentin na-arụ ọrụ megidere gram-positive na gram-ọjọọ aerobic na anaerobic pathogens, yana ihe ndị na-arụ ọrụ nke ọgwụ nwere mmetụta dị njọ na ụfọdụ ndị ọzọ na - akpata ọrịa.

    Ọgwụ a na-egosipụta oke ọrụ megide chlamydia, pale treponema (ihe na-akpata ọrịa syphilis), nje na-akpata mmepe nke leptospirosis, colic Escherichia, staphylococci, streptococci, Klebsiella, listeria, bacilli, clostridia, brucellarlamellella, vagina, other ụmụ nje.

    Offọdụ n'ime nje nje ndị a na-emepụta beta-lactamases, nke na-eduga na iguzogide ọgwụ nje ndị a na ọgwụ ndị na-arụ ọrụ nke ọgwụ ahụ.

    Ngwongwo ogwu

    Mbadamba nke Augmentin bụ ọgwụ ogologo oge (nke na-eme ogologo oge), nke dị iche na ihe ndị ọzọ na-adabere na amoxicillin. N'ihi nke a, enwere ike iji ọgwụ ahụ mee ihe iji bibie nje na-efe efe na-egbochi penicillins.

    Mgbe ingestion gasịrị, ihe ndị na-arụ ọrụ nke augmentin - amoxicillin na clavulanic acid, na-agbari ngwa ngwa ma na-etinye obi gị dum na eriri afọ. Mmetụta ọgwụgwọ kachasị nke ọgwụ ahụ na-egosipụta ma ọ bụrụ na onye ọrịa ewere ọgwụ ahụ tupu nri. A na-ekesasị nsonaazụ nke ihe ndị na - arụ ọrụ nke ọgwụ ahụ n'ime akwara ndị dị n’ime ya - akwara obi, akwara afọ, anụ ahụ, na-abanye n’ime akwara, a na-ahụ ya na amịpụta sputum, mpụta purulent, ihe dị n’ime na mmiri intraarticular.

    Dika otutu penicillins, amoxicillin nwere ike igbanye n’ime mmiri ara. Site na nyocha ahụike, achọpụtawo ịchọpụta nke clavulanic acid n'ime mmiri ara. Ọgwụ a, dịka iwu, enyeghị ọgwụ maka ịgwọ ụmụ nwanyị na-actụ nwa n'ihi nnukwu ihe egwu dị na mkpokọta nsị nke arụ ọrụ Augmentin n'ime imeju nke nwa ọhụrụ, nke na-abanye ara ya na mmiri ara.

    E tinyekwara Augmentin n'ọmụmụ ihe nyocha na anụmanụ, n'oge a hụrụ na clavulanic acid na amoxicillin na-abanye na mgbochi Placental n'ime akpanwa, na nyocha, egosighi ihe ọ bụla ma ọ bụ mmetụta mbibi ọgwụ ndị a na nwa ebu n'afọ.

    A na - eke ahụ Amoxicillin site na ahụ onye ọrịa site na ebumpụta ụwa site na akụrụ, na acid clavulanic site na sistem siri ike na akwara. Ihe dị ka 1/10 nke mbụ ọgwụ amoxicillin na-apụ apụ na mmamịrị, ebe clavulanic acid na-aga n'ihu usoro metabolic ma akụkụ ya ụfọdụ na feces na mmamịrị.

    Kedu mgbe a na-ede Augmentin?

    Ihe kacha egosi nhọpụta nke mbadamba Augmentin bụ:

    • ọrịa nke elu akụkụ okuku ume na nasopharynx nke mbufụt na nje na - efe efe - mbufụt nke etiti ntị, mbufụt nke pharyngeal tonsils, pharyngitis, bronchitis mere site pathogenic microorganisms (streptococci, staphylococci) nwere mmetụta na ọgwụ mejupụtara,
    • Ọrịa na-efe efe nke ala akụkụ okuku ume na - na-enwekarị ụkwara ume ala, bronchopneumonia, mbufụt nke ọrịa ngụgụ anụ ahụ,
    • Ọrịa nje nke mkpụrụ ndụ akwara sitere na mkpụrụ nke ezinụlọ nje na Enterobacteria coli Escherichia, staphylococcus saprophyticus, enterococci, gonococci - usoro mbufụt nke ọnya, mkpali na usoro nje, ureters, mbufụt nke akwara akwara (intrasitial nephritis, prọfesula nje)
    • Ọrịa pustular nke anụ ahụ - pyoderma, Juda, carbuncles na ọnya ndị ọzọ,
    • Usoro nje na nkwonkwo na ọkpụkpụ - osteomyelitis nke ezinụlọ staphylococcus kpatara,
    • Nsogbu ndabara mgbe amuchara ịmụ nwa ma ọ bụ afọ ime bụ endometritis, salpingoophoritis, na ọrịa ndị ọzọ nke sistemụ ịmụ nwa, na - esite na ntoputa nke ọrịa pathogenic banye ahụ. Ọtụtụ mgbe, ọrịa mbufụt nke akpanwa na akụrụngwa ya nwere ike topụta n'ihi arụrụala nyocha emeghị emechi - historoscopy, ụda uterine, usoro ọgwụgwọ nke akwara uterine, njedebe akparamagwa nke afọ ime, wdg.

    Otu ihe ngosi banyere nhọpụta nke mbadamba Augmentin na-agwakọtakwa afọ ime dịka akụkụ nke ọgwụgwọ siri ike na ọgwụ ndị ọzọ.

    Ofzọ eji eme ihe na ị doụ ọgwụ

    Ndi dọkịta ghazie ịgwọ ọrịa na usoro onunu ogwu Augmentin n’otu n’otu n’otu n’otu n’otu n’otu n’otu. Ọ dị mkpa icheta na ọgwụ a bụ ọgwụ nje, yabụ na, dị ka ọgwụ ndị ọzọ, ị nweghị ike ị itụ ya n’enweghị ikike na mgbe ịchọrọ! Na mgbakwunye, ụfọdụ ọrịa na-akpata site na ụmụ irighiri ihe nke na-adịghị emetụta ihe ndị dị n'ọrụ nke mbadamba ahụ, dịka ọmụmaatụ, nje ma ọ bụ fungi.

    Ọkachasi nke ọgwụ a kpebiri na ọ dị n’aka ndị ọkachamara na-adabere n’ọtụtụ ihe: afọ onye ọrịa, nchọpụta ya, ọnụnọ nke nsogbu, ọrụ akụrụ na imeju onye ọrịa, oke ahụ na ọrịa.

    Iji nweta oke ohere ị theụ ọgwụ ahụ ma belata ihe ndị nwere ike ibute nsogbu ndị ahụ, a na-atụ aro mbadamba Augmentin ka ị were ya na mbido nri.

    Opekempe usoro ọgwụgwọ a ọgwụ dịkarịa ala ụbọchị 5. Ọ bụrụgodi na mgbaama niile nke ọrịa ahụ apụwo, na onye ọrịa ahụ adịkwa mma, n ’ụzọ ọ bụla ị ga-akwụsị ịgwọ ọrịa n’emezughi ụzọ dọkịta siri gosi. Ihe dị na ya bụ na microorganisms pathogenic na-eme ngwa ngwa ịgwọ ọgwụ ma ọ bụrụ na onye ọrịa ahụ kwụsịchaa ụzọ ọ ga-esi gwọọ ọrịa, mgbe ahụ akara ngosipụta nke ọrịa ahụ nwere ike ịlaghachi na ume ọhụrụ. N'okwu a, otu ụdị ọnụọgụ nje agaghị enwe mmetụta na mbadamba Augmentin, dọkịta ga-ewerekwa ihe ọhụrụ ma sie ike karị. Nke a n'aka nke a na-eduga n'ihe ize ndụ nke mmetụta ọjọọ yana mmebi imeju.

    Ọ bụrụ na a manyere onye ọrịa ị takeụ ọgwụ ahụ ihe karịrị ụbọchị 10, mgbe ahụ n'ụbọchị 11, a ga-enyocha ọbara iji nyochaa arụmọrụ ya. Mgbe izu abụọ gachara ị startụ ọgwụ a, ịkwesịrị ịtụleghachi mkpa maka ọgwụgwọ ọzọ ma ọ bụ kpebie nkwụsị nke ị theụ mbadamba. Okwesiri ighota na oria obula nwere usoro nke ya, dika ima atu, maka ogwugwo oria nke etiti, aghaghi ibu ihe kari ubochi asaa nye ndi okenye, ebe oria umuaka n’agbata afo abuo nwere ike n’iru rue ubochi iri.

    Ọ bụrụ na ọ dị mkpa ma ọ bụ gbagwojuru anya site na usoro mkpali na ọrịa, mgbe ụfọdụ, a na-edenye ndị ọrịa ụzọ nke mbụ inugmentin n'ụdị injections, na mgbe mwepụ nke mgbaàmà ọrịa na mmelite nke ọnọdụ ahụike niile, ị nwere ike ịgbanye na nchịkwa ọnụ nke ọgwụ ahụ, ya bụ, mbadamba.

    Usoro onunu ogwu maka umuaka

    Dịka iwu, ngụkọta oge nke mbadamba ọgwụ Augmentin kwa ụbọchị na omume ụmụaka na-adabere n'ọtụtụ ihe: oke ahụ nwatakịrị ahụ, ọrịa, ogo nke ọnọdụ ahụ, afọ onye ọrịa, yana ọnụnọ nke nsogbu. Maka ụmụaka na-eru ogo 40 n'arọ, a na-agbakọọ usoro ahụ dabere na mg / 1 n'arọ nke oke ahụ. Onu ogugu ogwu nke ogwu a ka ahuru n’otu n’otu n’otu n’otu n’otu n’otu nye ndi ọrịa. Weighmụaka na-eru ihe karịrị kilogram 40 na-anara ọgwụgwọ dị ka usoro “okenye”.

    Maka ọgwụgwọ nke nje na-efe efe nke anụ ahụ na anụ ahụ dị nro, pharyngitis na tonsillitis na-adịghị ala ala, obere usoro nke augmentin zuru ezu. Maka ọgwụgwọ nke ọrịa ndị dị ka sinusitis, mbufụt nke etiti ntị, usoro mkpali nke akụkụ elu na ala akụkụ okuku ume, cystitis, pyelonephritis na mbufụt nke akụkụ ahụ nke mkpụrụ ndụ, achọrọ ọgwụ dị elu.

    A naghị eji ọgwụ Augmentin dị n'ụdị mbadamba eme ihe maka ọgwụgwọ ụmụaka maka ọgwụgwọ nke ndị ọrịa na-erubeghị afọ abụọ, ebe ọ bụ na enweghị data nyocha ọhụụ banyere nchekwa nke ụdị ọgwụgwọ ahụ.

    Ọgwụ Augmentin maka ndị okenye na ụmụaka karịrị afọ 14

    Ndị okenye na ụmụaka gbagoro afọ 14 ma ọ bụ ndị ọrịa karịrị 40 n'arọ ka edere Augmentin na ọnụego mbadamba 1 ugboro atọ kwa ụbọchị maka ọgwụgwọ nke ọrịa na-efe efe dị nwayọọ na-agafe agafe. Maka ọgwụgwọ nke usoro mgbagwoju anya ma ọ bụ ọrịa dị elu na ndị okenye na ụmụaka karịa afọ 14, dị ka iwu, a na-edenye usoro ọgwụ ndị ọzọ, ugboro ugboro ka injers.

    Maka ndị ọrịa ịla ezumike nká bụ́ ndị nwere nnukwu ọrụ nke akụrụ na umeji, ndị dibịa bekee na-agbazi usoro ọgwụ kwa ụbọchị.

    Nsonaazụ

    Site n'iji ọgwụ Augmentin n'ụzọ ziri ezi na usoro ọnụọgụ ọnụọgụ ọ bụla, ndị ọrịa na-anabatakarị ọgwụ niile. N'ọnọdụ ụfọdụ, na-emetụta mmetụta nke ọgwụ ahụ n'otu n'otu, mmetụta ndị ọzọ na-esote nwere ike ịmalite:

    • Site n’akụkụ ọwara nri: ọgbụgbọ, ihe mgbu n’ime afọ, imebi ume, ọgbụgbọ, afọ ọsịsa, akwara ọrụ, mmepe nke ịba ọcha n’anya.
    • Site na akụkụ ahụ urinary: nnukwu nsogbu gbasara akụrụ, oliguria, ọrụ ezughi oke,
    • Site na sistemụ na etiti na nsogbu: ọgbụgbọ, ihe ọgbụgba, isi ọwụwa, ehighị ụra, ma ọ bụ, na ujo, ụra nke ukwuu, ihe mgbaàmà nke ịxụ ahụ, nke gosipụtara n’ike adịghị ike, nzaghachi na-adịghị mma maka ihe na-eme gburugburu.

    Ọrịa ndị a na - ahụkarị bụ rashes, akpụkpọ ahụ, ihe mgbochi (nwanyị nwere nwanyị na ọnya).

    Site na ịgbasochi usoro onunu ogwu nke dọkịta nyere si wee nyere gị ezigbo njikwa ọgwụ a, nsonaazụ ọ bụla site n'ị takingụ Augmentin na-etolite naanị n'okwu ikpe.

    Ihe ngbanwe

    N’agbanyeghi otutu mmetụta ha di, mbadamba Augmentin nwere otutu contraindications. Ndị a gụnyere:

    • Onye na anabataghi penicillins, cephalosporins,
    • Hypersensitivity na ihe inyeaka nke ọgwụ ahụ,
    • Ọrịa siri ike nke imeju na akụrụ.
    • Undermụaka n’agbata afọ abụọ,
    • Mononucleosis na-efe efe - mgbe ị na-eji mbadamba ọgwụ augmentin nwere nchoputa a, ihe nfụkasị ahụ nwere ike ịpụta n’akpụkpọ ahụ onye ọrịa, nke ga-agbagha nchọpụta zuru oke banyere ọrịa ahụ.

    Ojiji nke ogwu n’oge di ime na inye ndi ara ara

    A na-anwale Augmentin n'ụlọ nyocha anụmanụ. Dabere na n'ọtụtụ ọmụmụ, mbadamba ọgwụ ahụ, ọbụlagodi na oke doses, enweghị mmetụta mutagenic na teratogenic na nwa ebu n'afọ. Na agbanyeghị nke a, ojiji nke ọgwụ dabere na amoxicillin na clavulanic acid dị n’ime ụmụ nwanyị dị ime bụ nke contraindicated, ọkachasị n’oge ọnwa atọ mbụ nke ịtụrụ ime. N’ime izu iri na abụọ mbụ, itinye akụkụ ahụ niile na nwa ebu n’afọ na-ewere ọnọdụ, ị nweta ọgwụ ọ bụla n’oge a nwere ike ibute oke ọgbụgba akwara na, n’ihi nke a, abnormalities nke intrauterine development. Na mgbakwunye, mgbe ndị ọkà mmụta sayensị nwalere ọgwụ ahụ n'ime nwanyị mụrụ nwa na-enweghị ike ịmụ nwa, achọpụtara na ọbụna ọgwụ prophylactic nke ọrịa augmentitis na-abawanye ohere nke necrotic colitis na ụmụ amụrụ ọhụrụ.

    Dika ntuziaka ogwu ahu si di, a ga-ewere Augmentin n’oge mmegharị naanị n’ọnọdụ ndị kacha njọ ma nyekwa na uru nwanyị nyere ga-akarị n’ihe ọ bụla nwere ike ibute nsogbu n’akụkụ nwa ebu n’afọ.

    Iji Augmentitis mee ihe n'oge a na-enye nwa ga-ekwe omume, kama ọ bụ naanị dabere n'ihe ngosipụta siri ike yana n'okpuru nlekọta dọkịta. N'ọnọdụ ọ bụla, nwanyị na-enye nwa ara gafere oke ọgwụ dọkịta gosipụtara, ebe ọ bụ na amoxicillin na-abanye nke ọma n'ime mmiri ara ara ma na oke mgbakwunye nwere ike ibute nsonaazụ imeju nwa, bụ nke juputara na mmepe nke mmetụta ndị ọzọ na ụmụ ọhụrụ. Na mgbakwunye na ihe egwu a, enweghị mmetụta na-adịghị mma nke Augmentin nwere n'ahụ nwa ọhụrụ na-anara ara ara n'ọtụtụ ọmụmụ.

    Ntụziaka pụrụ iche

    Tupu ịmalite ị thisụ ọgwụ a, onye ọrịa ahụ aghaghị inye dọkịta ahụ ihe ndekọ zuru ezu banyere ịnagide ọgwụ nke penicillin otu na cephalosporins. Na mgbakwunye, ọ dị mkpa igosipụta ma enweela akụkọ mgbe ọ bụla nke mmeghachi omume nfụkasị ọ bụla na ọgwụ na ihe ndị mejupụtara ha.

    Na ọgwụ, ọtụtụ ikpe nke mmepe nke mmeghachi omume nfụkasị dị ukwuu nke ndị ọrịa na ọgwụ ndị nwere penisilini. N'ọnọdụ ụfọdụ, ujo anafilactic site na nchịkwa ọgwụ na-egbu egbu! Ihe ọghọm nke imepụta ụdị nfụkasị ahụ na penisiliniins ma ọ bụ cephalosporins bụ nke ukwuu na ndị ọrịa nwere ọrịa ketara eketa ma ọ bụ na ndị nwere ngosipụta na-adịghị mma n'oge gara aga na nzaghachi nke amoxicillin ma ọ bụ ọgwụ ndị ọzọ dabeere na penicillin. N'inwe ihe egwu dị elu nke ọgwụ ahụ, dọkịta kwesịrị ịhọrọ usoro ọgwụgwọ ọzọ maka onye ọrịa ahụ ga-adịkwa mma, mana ọ nweghị nchebe maka ahụ onye ọrịa.

    Site na mmepe nke nsogbu anaphylactic ure ma ọ bụ ụbụrụ Quincke na nzaghachi na ntinye ma ọ bụ nnabata nke Augmentin, onye ọrịa ahụ kwesịrị ịbanye adrenaline ozugbo, iv glucocorticosteroid homonụ. Na nnukwu ọzịza na ịta ahụhụ nke onye ọrịa ahụ, ekwesịrị ịdị na-enyocha ikuku ozugbo; maka nke a, enwere ike ịchọ ịba uru tracheal.

    A na-eji mbadamba Augmentin na-akpachapụ anya maka ịgwọ ndị agadi na ndị ọrịa nwere nnukwu akụrụ na ọrịa ịba ọcha n'anya.

    Iji belata ihe ize ndụ nke mmetụta ndị sitere na sistem nri nri na-a theụ ọgwụ, a na-atụ aro mbadamba ọgwụ augmentin ka ị were ya ná mmalite nke nri.

    Mgbe ha bukwasịrị mbadamba nkume ndị ahụ, a na-adụ ndị ọrịa ọrịa na-enyocha enamel eze aka ka ha hichaa ezé ha nke ọma ka ha wee zere ire ere ma ọ bụ imeju enamel ahụ.

    Ndị ọrịa na-amalite ị drugsụ ọgwụ ọgwụ amoxicillin na-enwekarị ike iwelie oge prothrombin. Ọ bụ ya mere site na ọgwụgwọ augmentin na anticoagulants na-eme n'otu oge, ndị ọrịa kwesịrị ile ule ọbara kwa oge iji nyochaa mmeghachi omume.

    Ndị ọrịa nwere diureis (urination) belatara-apụtakarị kristal na mmamịrị. Dịka iwu, akara ngosi a na-aputa ihe na nnabata nke ọgwụ.N'oge usoro ọgwụgwọ ọgwụ ọgwụ amoxicillin, a na-atụ aro ka onye ọrịa ahụ rie oke mmiri dị ọcha iji gbochie ịmepụta kristal ọgwụ na mmamịrị.

    Treatmentụ ọgwụ Augmentin ogologo oge nwere ike ibute ngwa ngwa nke microorganisms anaghị eche na akụkụ nke ọgwụ ahụ. N'ime oge iji ọgwụ ogologo oge, a na-atụ aro ka nyochaa ọrụ nke akụrụ, imeju na hematopoiesis site na mmamịrị na ule ọbara.

    N'oge ọgwụgwọ ya na Augmentin, amachibidoro ị drinkụ ihe ọholicụholicụ na-egbu egbu egbu, ebe ọ bụ na ị ofụ mmanya na ihe ndị na-arụ ọrụ nke ọgwụ ahụ nwere ike ibute nsị na nsị na usoro akwara.

    Mbadamba Augmentin enweghị mmetụta na-adịghị mma na ọnụego mmeghachi ya ma ọ dịghị emetụta njikwa ụgbọ ala na usoro ndị ọzọ.

    Mmekọrịta nke ọgwụ ya na ọgwụ ndị ọzọ

    Agaghị atụ aro mbadamba Augmentin ka a na-ewere ya n'otu oge Allopurinol n'ihi nnukwu ihe ize ndụ nke mmeghachi omume nfụkasị ahụ na nsonaazụ ya na onye ọrịa. Ọ bụrụ na ị na-ewere Allopurinol, ị kwesịrị ịgwa dọkịta gị hoo haa.

    N'oge ojiji nke Augmentin, yana ọgwụ mgbochi ọgwụ ọ bụla nke ọgwụ penicillin, ịdị irè nke ọgwụ mgbochi ịmụ nwa nwere ike ibelata, nke kwesịrị ịmara ụmụ nwanyị họọrọ ụdị nchebe megide ịtụrụ ime na-achọghị.

    Ndị na-ahụ maka ọgwụ

    Ntụ ntụ maka nkwụsị ọnụ5 ml
    bekee arụ ọrụ:
    amoxicillin trihydrate (na usoro nke amoxicillin)125 mg
    200 mg
    400 mg
    potassium clavulanate (na usoro nke clavulanic acid) 131,25 mg
    28.5 mg
    57 mg
    ndị na-ebu ụzọ: xanthan gum - 12.5 / 12.5 / 12.5 mg, aspartame - 12.5 / 12.5 / 12.5 mg, succinic acid - 0.84 / 0.84 / 0.84 mg, colloidal silicon dioxide. - 25/25/25 mg, hypromellose - 150 / 79.65 / 79.65 mg, oroma oroma 1 - 15/15/15 mg, oroma 2 - 11.25 / 11.25 / 11.25 mg, flavour utu - 22.5 / 22.5 / 22.5 mg, isi ahụ "Molasses Light" - 23.75 / 23.75 / 23.75 mg, silicon dioxide - 125 / ruo 552 / ruo 900 mg

    1 N'ime mmepụta ọgwụ, a na-edobe ọgwụ clavulanate potassium na ngafe 5%.

    Mbadamba ihe mkpuchiTaabụ 1.
    bekee arụ ọrụ:
    amoxicillin trihydrate (na usoro nke amoxicillin)250 mg
    500 mg
    875 mg
    potassium clavulanate (na usoro nke clavulanic acid)125 mg
    125 mg
    125 mg
    ndị na-ebu ụzọ: magnesium stearate - 6.5 / 7.27 / 14.5 mg, sodium carboxymethyl stachi - 13/21/29 mg, colloidal silicon dioxide - 6.5 / 10.5 / 10 mg, MCC - 650 / ruo 1050/396, 5 mg
    n'ọbọ ihe nkiri: titanium dioxide - 9.63 / 11.6 / 13.76 mg, hypromellose (5 cps) - 7.39 / 8.91 / 10.56 mg, hypromellose (15 cps) - 2.46 / 2.97 / 3.52 mg, macrogol 4000 - 1.46 / 1.76 / 2.08 mg, macrogol 6000 - 1.46 / 1.76 / 2.08 mg, dimethicone 500 ( mmanụ silicone) - 0.013 / 0.013 / 0.013 mg, mmiri dị ọcha 1 - - / - / - -

    A na-ewepụ mmiri dị ọcha n'oge mkpuchi ihe nkiri.

    Nkọwa nke ụdị usoro onunu ogwu

    Ntụ ntụ: ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, nwere njirimara na-esi isi. Mgbe diluted, etisasị na-acha ọcha ma ọ bụ ihe fọrọ nke nta ọcha. Mgbe ị kwụ ọtọ, ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọma na-eji nwayọọ nwayọọ.

    Mbadamba ụrọ, 250 mg + 125 mg: kpuchie ya na ihe nkiri site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oval ke udi, ya na ihe odide a bu "AUGMENTIN" n'otu akụkụ. N'oge kink: site na ọcha na-acha odo odo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

    Mbadamba ụrọ, 500 mg + 125 mg: kpuchie ya n'ọbọ ihe nkiri site na ọcha rue ihe fọrọ nke nta ka ọ bụrụ ọcha na agba, oval, nke e dere ihe akpọrọ "AC" yana ihe egwu dị n'otu akụkụ.

    Mbadamba ụrọ, 875 mg + 125 mg: kpuchie ya n'ọbọ ihe nkiri site na ọcha rue ihe fọrọ nke nta ka ọ bụrụ ọcha, na oval n'ụdị ya, ya na mkpụrụedemede "A" na "C" n'akụkụ ya na ahịrị mmebi dị n'otu akụkụ. N'oge kink: site na ọcha na-acha odo odo ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

    Mlọ ọgwụ

    Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri dị nro dị n'ọtụtụ ọgụ na -emegide ọtụtụ gram-positive na gram-microorganisms. N'otu oge ahụ, amoxicillin nwere ike ibute mbibi site na beta-lactamases, yabụ kwa ụdị ọrụ nke amoxicillin anaghị erute microorganisms nke na-emepụta enzyme a.

    Clavulanic acid, ihe dị na beta-lactamase inhibitor n'ihe metụtara penicillins, nwere ike ịhapụ ịgbatị ọtụtụ beta-lactamases ndị a hụrụ na penisilini na cephalosporin na-eguzogide ọgwụ. Clavulanic acid na-arụ ọrụ nke ọma megide plasmid beta-lactamases, nke na-abụkarị maka nje na-eguzogide ọgwụ, ọ nweghịkwa arụ ọrụ megide chromosomal beta-lactamases nke ụdị 1st, nke clavulanic acid na-egbochi.

    Ọnụnọ nke clavulanic acid dị na nkwadebe Augmentin protects na-echebe amoxicillin site na mbibi site na enzymes - beta-lactamases, nke na-enye ohere ịgbasa ụdị nje antibacterial nke amoxicillin.

    Ihe ndị a bụ ọrụ nke ngwakọta nke amoxicillin na clavulanic acid in vitro .

    Nje bacteria na-agbakarị ọgwụ ma ọ bụrụ na agwakọta nke amoxicillin na clavulanic acid

    Airabes ọma Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia astero> gụnyere Ihe eji eme plogenes nke okirikiri 1.2, Streptococcus agalactiae 1.2 (beta ọzọ hemolytic streptococci) 1,2, Staphylococcus aureus (chebara methicillin) 1, Staphylococcus saprophyticus (na-emetụta methicillin), coagulase-sta staloloccci (na-emetụta methicillin).

    Girata dị mma: Clostr> gụnyere Peptostreptococcus magnus, Peptostreptococcus micros.

    Gram-ọjọọ aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

    Gram-ọjọọ anaerobes: Bactero> gụnyere Bactero> gụnyere Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

    Ndị ọzọ: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

    Nje nke bu nje nke nwetara ihe ojoo na nchikota amoxicillin na clavulanic acid nwere ike idi

    Gram-ọjọọ aerobes: Escherichia coli 1, Klebsiella spp., gụnyere Klebsiella oxytoca, Klebsiella poniaoniae 1, Proteus spp., gụnyere Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

    Airabes ọma Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2 otu na - arụ ọrụ Idmụ nje.

    Nje bacteria na -eche na -echeta njikọta nke amoxicillin na clavulanic acid

    Gram-ọjọọ aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

    Ndị ọzọ: Chlamydia spp, gụnyere Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

    1 Maka ụmụ nje ndị a, a gosipụtara arụmọrụ ọgwụgwọ nke amoxicillin na clavulanic acid na ọmụmụ ụlọ ọgwụ.

    2 Usoro nje nke ụdị nje a anaghị arụpụta beta-lactamase. Ihe mmetụta uche na amoxicillin monotherapy na-atụ aro inwe uche yiri nke ahụ na nchikota nke amoxicillin na clavulanic acid.

    Mlọ ọgwụ

    Ngwakọta ọrụ niile dị na nkwadebe Augmentin - - amoxicillin na clavulanic acid - na - ewebata ngwa ngwa site na eriri afọ mgbe nchịkwa ọnụ gasịrị. Ntinye nke ihe aru oru n’ime ogwu Augmentin ® di ezigbo nma ma oburu ị takingụ ogwu n’oge mbido nri.

    E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo ahụike dị afọ 2-12 afọ na afọ efu were 40 mg + 10 mg / kg / ụbọchị nke ọgwụ Augmentin ® na usoro atọ, ntụ ntụ maka nkwụsị ọnụ, Mg mg + 31,25 na 5 ml (156.25 mg).

    Mpempe ọgwụ pharmacokinetic nke bụ isi

    Amoxicillin

    Augmentin ®, mg mg + 31.25 mg na 5 ml

    Clavulanic acid

    Augmentin ®, mg mg + 31.25 mg na 5 ml

    ỌgwụDose mg / n'arọCmax mg / lNdimax hAUC, mg · h / lNdi1/2 h
    407,3±1,72,1 (1,2–3)18,6±2,61±0,33
    102,7±1,61,6 (1–2)5,5±3,11,6 (1–2)

    A na-egosi usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid dị na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo ahụike dị afọ 2-12 afọ na afọ efu weere Augmentin ®, ntụ ntụ maka nkwụsị ọnụ, 200 mg + 28.5 mg na 5 ml (228) , 5 mg) na nha nke 45 mg + 6.4 mg / kg / ụbọchị, kewara abụọ.

    Mpempe ọgwụ pharmacokinetic nke bụ isi

    Ihe eji arụ ọrụCmax mg / lNdimax hAUC, mg · h / lNdi1/2 h
    Amoxicillin11,99±3,281 (1–2)35,2±51,22±0,28
    Clavulanic acid5,49±2,711 (1–2)13,26±5,880,99±0,14

    E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo nwere ahụike weere otu ọgwụ Augmentin ®, ntụ ntụ maka nkwusi ọnụ, 400 mg + 57 mg na 5 ml (457 mg).

    Mpempe ọgwụ pharmacokinetic nke bụ isi

    Ihe eji arụ ọrụCmax mg / lNdimax hAUC, mg · h / l
    Amoxicillin6,94±1,241,13 (0,75–1,75)17,29±2,28
    Clavulanic acid1,1±0,421 (0,5–1,25)2,34±0,94

    Thelọ ọgwụ ọgwụ pharmacookinetic nke amoxicillin na clavulanic acid, enwetara n'ọmụmụ ihe dị iche iche, mgbe ndị ọrụ afọ ofufo na-ebu ọnụ na-arịa ọrịa were:

    - 1 taabụ. Augmentin ®, 250 mg + 125 mg (375 mg),

    - 2 mbadamba Augmentin ®, 250 mg + 125 mg (375 mg),

    - 1 taabụ. Augmentin ®, 500 mg + 125 mg (625 mg),

    - 500 mg nke amoxicillin,

    - 125 mg nke clavulanic acid.

    Mpempe ọgwụ pharmacokinetic nke bụ isi

    Amoxicillin na nchịkọta nke ọgwụ Augmentin ®

    Clavulanic acid n'ime ihe mejupụtara ọgwụ Augmentin drug

    ỌgwụMpempe ogwuCmax mg / mlNdimax hAUC, mg · h / lNdi1/2 h
    Augmentin ®, 250 mg + 125 mg2503,71,110,91
    Augmentin ®, 250 mg + 125 mg, mbadamba 25005,81,520,91,3
    Augmentin ®, 500 mg + 125 mg5006,51,523,21,3
    Amoxicillin 500 mg5006,51,319,51,1
    Augmentin ®, 250 mg + 125 mg1252,21,26,21,2
    Augmentin ®, 250 mg + 125 mg, mbadamba 22504,11,311,81
    Clavulanic acid, 125 mg1253,40,97,80,7
    Augmentin ®, 500 mg + 125 mg1252,81,37,30,8

    Mgbe ị na-a Augụ ọgwụ Augmentin pla, ihe ndị na-enye nsogbu na plasma nke amoxicillin yiri nke ndị na-ahụ maka nchịkwa ọnụ nke amoxicillin hà.

    Thelọ ọgwụ ọgwụ pharmacookinetic nke amoxicillin na clavulanic acid, enwetara n'ọmụmụ akwụkwọ dị iche iche, mgbe ndị ọrụ afọ ofufo na-ebu ọnụ na-arịa ọrịa were:

    - 2 mbadamba Augmentin ®, 875 mg + 125 mg (1000 mg).

    Mpempe ọgwụ pharmacokinetic nke bụ isi

    Amoxicillin na nchịkọta nke ọgwụ Augmentin ®

    Augmentin ®, 875 mg + 125 mg

    Clavulanic acid n'ime ihe mejupụtara ọgwụ Augmentin drug

    Augmentin ®, 875 mg + 125 mg

    ỌgwụMpempe ogwuCmax mg / lNdimax hAUC, mg · h / lNdi1/2 h
    175011,64±2,781,5 (1–2,5)53,52±12,311,19±0,21
    2502,18±0,991,25 (1–2)10,16±3,040,96±0,12

    Dị ka ọ dị na ntinye iv nke ngwakọta nke amoxicillin na clavulanic acid, a na-ahụkarị ọgwụ amoxicillin na clavulanic acid n'ọtụtụ anụ ahụ na ọnya ọnya dị iche iche (ọnya afọ, ọnya afọ, anụ ahụ, abụba na akwara anụ ahụ, ọnya synovial na peritoneal fluid, fluid) )

    Amoxicillin na clavulanic acid nwere ogo na-esighi ike nke na-ejikọ protein protein. Nnyocha e mere egosiwo na ihe dị ka 25% nke ngụkọta nke clavulanic acid na 18% nke amoxicillin na plasma ọbara na-emetụta protein protein plasma.

    N'ime ọmụmụ anụmanụ, enweghị nchịkọta akụkụ nke nkwadebe Augmentin in na anụ ahụ ọ bụla achọtara.

    Amoxicillin, dị ka ọtụtụ penisiliniins, na-abanye n'ime mmiri ara. A nwekwara ike ịchọta akụkụ nke clavulanic acid na mmiri ara. Ewezuga enwere ike ịmalite ịrịa ọrịa ọnya ọnya na ọnya mmamịrị, ọnweghị mmetụta ndị ọzọ nke amoxicillin na clavulanic acid na ahụike nke ụmụ a na-enye ara.

    Ọmụmụ banyere ọmụmụ ụmụ anụmanụ egosila na amoxicillin na clavulanic acid na-agafe ihe mgbochi placental. Agbanyeghị, ọ nweghị mmetụta dị njọ na nwa ebu n’afọ achọpụtara.

    10-25% nke ọgwụ mbu nke amoxicillin bụ nke akụrụ na - eme ka metabolite na - adịghị arụ ọrụ (penisilloic acid). Clavulanic acid bụ metabolized nke ukwuu ruo 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid na amino-4-hydroxy-butan-2-otu ma wepụta ya site na akụrụ Ọkụ afọ, yana ikuku kubie ume n'ụdị carbon dioxide.

    Dị ka ọgwụ penicillins ndị ọzọ, amoxicillin na-apụkarị site na akụrụ, ebe a na-ahụ ọgwụ clavulanic acid site na usoro gbasara akụrụ na extrarenal.

    Ihe dị ka 60-70% nke amoxicillin na ihe dị ka 40-65% nke clavulanic acid bụ nke akụrụ na-agbanweghị na aka elekere isii mbụ ka emesịrị 1 tebụl. 250 mg + 125 mg ma ọ bụ mbadamba 1 500 mg + 125 mg.

    Oge nlekọta probenecid na-eme ka a kwụsịlata amoxicillin, mana ọbụghị clavulanic acid (lee "Mmekọrịta").

    Na-egosi Augmentin ®

    E gosipụtara nchikota nke amoxicillin na clavulanic acid maka ọgwụgwọ nke nje na-efe efe nke ọnọdụ ndị na-esonụ nke microorganisms nwere mmetụta na nchikota nke amoxicillin na clavulanic acid:

    ọrịa elu akụkụ akụkụ iku ume (gụnyere ọrịa ENT), dịka ọmụmaatụ tonsillitis, sinusitis, otitis media, na-ebutekarị Ahụ ike oyi na-akpata prọdia, Hemophilus influenza 1, Moraxella catarrhalis 1 na plogenes nke Streptococcus, (ewezuga mbadamba Augmentin 250 mg / 125 mg),

    Ọrịa dị ala nke akụkụ okuku ume na akwara, dị ka nkụda mmụọ nke ụkwara ume ọkụ, ụkwara ume ọkụ, na ọnya na-efe efe, bụ́ nke na-akpatakarị. Ahụ ike oyi na-efe efe nke Hemophilus 1 na Moraxella catarrhalis 1,

    ọrịa ọnya na-efe efe, dị ka cystitis, urethritis, pyelonephritis, ọrịa nke akụkụ nke akụkụ nke nwanyị, nke na-akpatakarị ụdị ezinụlọ. Enterobacteriaceae 1 (kachasị Escherichia coli 1 ), Staphylococcus saprophyticus na umu Enterococcusyana gonorrhea kpatara Neisseria gonorrhoeae 1,

    Akpịrị anụ ahụ na anụ ahụ dị nro na-ebutekarị Staphylococcus aureus 1, pyogenes Streptococcus na umu Bacteroides 1,

    Ọkpụkpụ nke ọkpụkpụ na nkwonkwo, dịka osteomyelitis, na-ebutekarị Staphylococcus aureus 1, ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume ịgwọ ọrịa ogologo oge.

    ọrịa odontogenic, dịka ọmụmaatụ periodontitis, odontogenic maxillary sinusitis, ọnụnọ ezé siri ike na mgbasa cellulite (naanị maka mkpụrụ osisi Augmentin, ọnụọgụ 500 mg / 125 mg, 875 mg / 125 mg),

    ọrịa ndị ọzọ jikọtara ọnụ (dịka ọmụmaatụ, afọ ime septic, postpartum sepsis, serais intraabdominal) dị ka akụkụ nke usoro ọgwụgwọ (naanị maka mbadamba Augmentin onunu ogwu 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

    1 Ndị nnọchite anya nke ụdị microorganisms akọwapụtara na-emepụta beta-lactamase, nke na-eme ka ha bụrụ ndị na-enweghị mmetụta na amoxicillin (lee. Pharmacodynamics).

    Ọrịa Augmentin be nwere ike ịgwọ ọrịa ndị microorganisms na-emetụta amoxicillin, ebe ọ bụ na amoxicillin bụ otu n'ime ihe ndị dị na ya. Augmentin ® ka egosiri maka ọgwụgwọ nke ọrịa nje jikọtara nke microorganisms nke nwere amoxicillin, yana microorganisms na-emepụta beta-lactamase, na-emetụta nchikota nke amoxicillin na clavulanic acid.

    Ọkpụkpọ nke nje bacteria na nchikota amoxicillin na clavulanic acid dịgasị iche dabere na mpaghara na oge. N'ebe enwere ike, ekwesiri iburu n'uche ọgụgụ data mpaghara. Ọ bụrụ na ọ dị mkpa, a ga-anakọta ma nyocha microbiological maka ịchọpụta ihe banyere nje.

    Ime na lactation

    Na nyocha nke omumu omumu na anumanu, onu na ochichi nke Augmentin cause emeghi teratogenic.

    N'ime otu nnyocha ụmụ nwanyị nwere membranes akatabeghị aka, achọpụtara na ọgwụ prophylactic na Augmentin be nwere ike ibute oke ihe egwu nke ọrịa enterocolitis n'ime ụmụ amụrụ ọhụrụ. Dịka ọgwụ niile, a naghị atụ aro ọgwụ Augmentin iji mee n'oge afọ ime, belụsọ na uru nne elere anya nne ga-akacha n'ihe nwa ebu n’afọ.

    Enwere ike iji ọgwụ Augmentin ® mee ihe n’oge a na-enye nwa ara. Ewezuga nke enwere ike ịmalite ịrịa afọ ọsịsa ma ọ bụ candidiasis nke akpụkpọ ahụ mucous nke oghere a na-ejikọta ya na ntinye ọnya ọnya nke ọgwụ a n'ime mmiri ara, ọ nweghị mmetụta ọjọọ ndị ọzọ hụrụ na ụmụ a na-enye ụmụ ara.N'ọnọdụ mmetụta ọjọọ na ụmụaka ndị na-enye nwa ara, ọ dị mkpa ịkwụsị ị -ụ ara.

    Nsonaazụ

    Edeputara ihe ojoo ndi a dị n’okpuru dị ka mmebi nke akụkụ ahụ na akụrụngwa na ugboro ole nke ihe omume. A na-ekpebi ugboro ole ihe a mere na-esote: ọtụtụ mgbe - ≥1 / 10, mgbe ≥1 / 100 na PV, anaemia, eosinophilia, thrombocytosis.

    Si dịghịzi usoro: ọ dịkarịsịrị ala - angioedema, mmeghachi omume anaphylactic, ọrịa nke metụtara ọrịa ọbara, vasculitis nfụkasị.

    Si ụjọ usoro: ugboro ugboro - ọgbụgbọ, isi ọwụwa, obere adịkarịghị - mgbanwe mgbanwe hyperactivity, nkwonkwo (nkwarụ nwere ike ịdakwasị ndị ọrịa nwere ọrụ mkpo ya, yana ndị na-anata oke ọgwụ ahụ), nsogbu ehighị ụra, oke iwe, nchekasị, mgbanwe omume.

    - ndị okenye: ọtụtụ mgbe - afọ ọsịsa, ọtụtụ mgbe - ọgbụgbọ, ọgbụgbọ,

    - ụmụ: mgbe mgbe - afọ ọsịsa, ọgbụgbọ, ọgbụgbọ,

    - onu ogugu ndi mmadu: otutu mgbe a na --eme ya na iji oke ogwu. Ọ bụrụ na mgbe ịmalite ị drugụ ọgwụ ọgwụ ahụ enwere mmeghachi omume na-adịghị mma site na eriri afọ, a ga-ewepụ ha ma ọ bụrụ na a na-ewere Augmentin at na mbido nri, na-agbakarị mgbaze, na-adịghị ahụkebe ọgwụ nje (gụnyere pseudomembranous colitis na ọbara ọgbụgba). »Ire, gastritis, stomatitis, disloration nke elu oyi akwa enamel umu. Ilekọta onụ na-enyere gị aka ịpụpụ ezé, ebe ọ bụ na ichi ezé ezuru gị.

    N'akuku nke imeju na akwara biliary: ugboro ugboro - mmụba dị ala na ọrụ nke AST na / ma ọ bụ ALT. A na-ahụ ihe ịtụnanya a na ndị ọrịa na-anara ọgwụ mgbochi beta-lactam, mana amabeghị ịdị mkpa ya banyere ọgwụ. O siri ike - ịba ọcha n'anya na cholestatic jaundice. A na-ahụ ihe ịtụnanya a na ndị ọrịa na-anara ọgwụgwọ na ọgwụ penicillin na cephalosporins. Mmụba nke bilirubin na alkaline phosphatase.

    A na-ahụta mmetụta na-adịghị mma site na imeju ndị ikom na ndị agadi ma nwee ike jikọta ya na ọgwụgwọ ogologo oge. Ọ bụghị obere ụmụaka ka a hụrụ ihe ọjọọ ndị a.

    Ihe iriba ama na akara a edepụtara na-eme n’oge ma ọ bụ ozugbo ngwụcha ọgwụgwọ, mana n’ọnọdụ ụfọdụ ha enweghị ike ịpụta ọtụtụ izu mgbe ha mechara ọgwụgwọ ahụ. A na - agbanwegharị ihe ọghọm. Ihe ojoo sitere na imeju nwere ike bụrụ ihe siri ike, n'ọnọdụ ndị a na-adịghị ahụkebe, enwere akụkọ banyere nsonaazụ na-egbu egbu. N'ihe fọrọ nke nta ka ọ bụrụ n'ọnọdụ niile, ndị a bụ ndị ọrịa nwere nnukwu ọnụọgụ mmụta ma ọ bụ ndị ọrịa na-anata ọgwụ nwere hepatotoxic.

    Na akpụkpọ anụ ahụ ugboro ugboro - ọnya, itching, urticaria, na-adịkarịghị erythema multiforme, nke ukwu Stevens-Johnson syndrome, necrolysis na-egbu egbu, dermatitis na-enweghị atụ, nnukwu exanthematous pustulosis.

    N'ọnọdụ mmeghachi omume nfụkasị anụ ahụ, a ga-akwụsị ịgwọ ya na Augmentin ®.

    Site na akụrụ na eriri afọ: dịkarịsịrị ala - nephritis interstitial, crystalluria (lee "overdose"), hematuria.

    Mmekorita

    A naghị atụ aro iji ọgwụ Augmentin ® na probenecid n'otu oge. Probenecid na-ebelata mmiri nzuzo nke amoxicillin, yabụ, iji ọgwụ ahụ eme ihe n'otu oge Augmentin ® na probenecide nwere ike ibute mmụba na nnọgide n'ọbara nke amoxicillin, mana ọbụghị clavulanic acid.

    Ojiji allopurinol na amoxicillin nwere ike ime ka ihe nwetakwuo mmetuta akpụkpọ ahụ. Ugbu a, enweghi data na akwụkwọ a na-eme n'otu oge nke ngwakọta nke amoxicillin na clavulanic acid na allopurinol.

    Penicillins nwere ike belata mkpochapụ nke methotrexate site na ahụ site na igbochi ihe nzuzo nke tubular ya, yabụ ojiji nke Augmentin na methotrexate nwere ike ịbawanye nsị nke methotrexate.

    Dị ka ọgwụ ndị ọzọ na-egbochi nje ihe, nkwadebe Augmentin can nwere ike imetụta microflora eriri afọ, na-eduga n'ịbelata nnabata estrogen site na eriri afọ yana mbelata ịdị irè nke ọgwụ mgbochi ọnụ.

    Akwukwo a na - akọwa okwu banyere obere mmụba na MHO n'ime ndị ọrịa yana jikọtara ọnụ nke acenocumarol ma ọ bụ warfarin na amoxicillin. Ọ bụrụ na ọ dị mkpa, ekwesịrị iji nlezianya nyochaa nhazi nke Augmentin ® na PV anticoagulants ma ọ bụ MHO mgbe ị na-ede ma ọ bụ kagbuo nkwadebe Augmentin;; ịhazigharị usoro ọgwụ anticoagulants maka nchịkwa ọnụ.

    Usoro onunu ogwu na nhazi

    Usoro usoro onunu ogwu ka edobere n’otu n’otu, dabere n’afọ, oke ahụ, ọrụ akụrụ nke onye ọrịa, yana ogo ọrịa ahụ.

    Iji belata nsị nke oghere ga-ekwe omume na iwelata ohere ị ,ụ mmanya, a ga-a drugụ ọgwụ ahụ na mbido nri. Obere oge nke ọgwụ mgbochi bụ ụbọchị 5.

    Ọgwụ ekwesịghị ịga n’ihu karịa ụbọchị iri na anọ na-enweghị nyocha banyere ọnọdụ ụlọ ọgwụ.

    Ọ bụrụ na ọ dị mkpa, a ga - enwe ike ịme ọgwụgwọ na - aga ije (usoro nchịkwa mbụ nke ọgwụ ahụ na ntinye ga - esote ya na nchịkwa ọnụ).

    Ekwesịrị icheta ya na taabụ 2 ahụ. Augmentin ®, 250 mg + 125 mg ezughị 1 mbadamba. Augmentin ®, 500 mg + 125 mg.

    Ndị okenye na ụmụaka gbara afọ 12 gbagoro ma ọ bụ karịa 40 n'arọ ma ọ bụ karịa. Ọ na-atụ aro iji 11 ml nke nkwusioru na usoro nke 400 mg + 57 mg na 5 ml, nke ya na 1 tebụl. Augmentin ®, 875 mg + 125 mg.

    Taabụ 1. 250 mg + 125 mg ugboro atọ kwa ụbọchị maka ọrịa oria dị nfe. Na ọrịa dị egwu (gụnyere ọrịa ọnya na-efe efe na-adịkarị ala, nke na-efe efe nke na-adịghị ala ala na nke nwatakịrị), a na-atụ aro usoro ndị ọzọ nke Augmentin..

    Taabụ 1. 500 mg + 125 mg ugboro atọ n'ụbọchị.

    Taabụ 1. 875 mg + 125 mg 2 ugboro n'ụbọchị.

    Agedmụaka dị n’agbata ọnwa atọ ruo afọ iri na abụọ n’arụ ahụ́ ya erughị 40 n'arọ. A na-eme ngụkọta oge dabere na afọ na oke ahụ, nke egosipụtara na mg / kg / ụbọchị ma ọ bụ na ml nke nkwusioru. A na-ekewa ọgwụ kwa ụbọchị ka usoro 3 kwa awa asatọ ọ bụla (125 mg + 31.25 mg) ma ọ bụ 2 doses kwa awa 12 ọ bụla (200 mg + 28.5 mg, 400 mg + 57 mg). Usoro usoro usoro onunu ogwu a ka akwadoro ka ana egosiputa ya na oge oru ya na tebulu di n'okpuru.

    Usoro Augmentin s usoro onunu ogwu (gbakọọ agbakọọ dabere na amoxicillin)

    DosesNkwụsị 4: 1 (125 mg + 31.25 mg na 5 ml), na usoro 3 n'ime elekere 8 ọ bụlaNkwụsị 7: 1 (200 mg + 28.5 mg na 5 ml ma ọ bụ 400 mg + 57 mg na 5 ml), na 2 usoro oge ọ bụla n'ime awa 12 ọ bụla.
    Dị ala20 mg / n'arọ / ụbọchị25 mg / n'arọ / ụbọchị
    Elu40 mg / n'arọ / ụbọchị45 mg / n'arọ / ụbọchị

    A na-atụ aro iji obere Augmentin ® maka ọgwụgwọ nke ọrịa anụ ahụ na anụ ahụ dị nro, yana tonsillitis ugboro ugboro.

    A na-akwado ọgwụ ka ukwuu nke Augmentin ® maka ịgwọ ọrịa dịka otitis media, sinusitis, ọrịa nke akụkụ okuku ume na akwara, ọrịa nke ọkpụkpụ na nkwonkwo.

    Enweghị data nyocha nke ụlọ ọgwụ ezughị ezu iji kwado ojiji nke Augmentin ® na ọgwụ nke karia 40 mg + 10 mg / kg na usoro 3 kewara (4: 1 nkwusioru) na ụmụaka na-erubeghị afọ abụọ.

    Umuaka site na omumu rue onwa ato. N'ihi ezumike nke akụrụ ahụ, ọgwụ a tụrụ aro ya nke Augmentin ® (ngụkọta maka amoxicillin) bụ mg mg 30 / kg / ụbọchị n'ime usoro 2 nke 4: 1.

    Umu amuru n’azu. Enweghị ntuziaka maka usoro usoro usoro onunu ogwu.

    Ndị otu ọrịa pụrụ iche

    Ndị okenye na-arịa ọrịa. Achọghị usoro maka usoro usoro usoro ọgwụgwọ ahụ; otu usoro usoro usoro ọgwụgwọ ahụ ka etinyere dịka ọ dị na ndị ọrịa na-eto eto. N'ime ndị ọrịa agadi nwere ezumike ọrụ ezumike, a na-enye usoro ọgwụgwọ kwesịrị ekwesị maka ndị ọrịa toro eto nwere ọrụ mgbazi arụ.

    Ndị ọrịa nwere ọria imeju. A na- eji nlezianya na-agwọ ọgwụgwọ; a na-enyocha ọrụ imeju. Enweghi data zuru oke iji gbanwee ntuziaka ọgwụ ndị a na ndị ọrịa dị.

    Ndị ọrịa nwere ọrụ mgbazinye nsogbu. Ntuzi nke usoro onunu ogwu sitere na oke agbadoro anya nke amoxicillin na uru ikike idozi creatinine.

    Usoro Augmentin ® usoro onunu ogwu

    Cl creatinine, ml / min4: 1 nkwusioru (125 mg + 31.25 mg na 5 ml)Nkwusioru 7: 1 (200 mg + 28.5 mg na 5 ml ma ọ bụ 400 mg + 57 mg na 5 ml)Mbadamba ihe eji etinye fim, 250 mg + 125 mgMbadamba ihe eji etinye fim, 500 mg + 125 mgMbadamba ihe eji etinye fim, 875 mg + 125 mg
    >30Enweghị mmezi usoro onunu ogwu achọrọEnweghị mmezi usoro onunu ogwu achọrọEnweghị mmezi usoro onunu ogwu achọrọEnweghị mmezi usoro onunu ogwu achọrọEnweghị mmezi usoro onunu ogwu achọrọ
    10–3015 mg + 3.75 mg / n'arọ ugboro abụọ n'ụbọchị, oke kachasị bụ 500 mg + 125 mg 2 ugboro n'ụbọchị—Taabụ 1. (o nwere ọrịa dị nfe na agafeghị oke) 2 ugboro n'ụbọchịTaabụ 1. (o nwere ọrịa dị nfe na agafeghị oke) 2 ugboro n'ụbọchị—
    N'ọbara, a ga-enye gị ọzọ ọgwụ nke 15 mg + 3.75 mg / n'arọ ka emesịa usoro hemodialysis.

    Mbadamba ihe eji etinye fim, 250 mg + 125 mg: Ndozi usoro onunu ogwu dabere na oke ọgwụ a tụrụ aro ya.

    2 taabụ. 250 mg + 125 mg na 1 dose kwa awa 24

    N'oge nnọkọ omalụ a, ihe ọzọ 1 (1 mbadamba) na mbadamba 1 ọzọ. na njedebe nke nnọkọ omalụ (iji kwụọ ụgwọ mbelata nke serum nke amoxicillin na clavulanic acid).

    Mbadamba ihe eji etinye fim, 500 mg + 125 mg: Ndozi usoro onunu ogwu dabere na oke ọgwụ a tụrụ aro ya.

    Taabụ 1. 500 mg + 125 mg na 1 dose kwa awa 24

    N'oge nnọkọ omalụ a, ihe ọzọ 1 (1 mbadamba) na mbadamba 1 ọzọ. na njedebe nke nnọkọ omalụ (iji kwụọ ụgwọ mbelata nke serum nke amoxicillin na clavulanic acid).

    Ofzọ nkwadebe nke nkwusioru

    A kwadebere nkwusioru ya ozugbo tupu ojiji izizi. Ihe dị ka milimita 60 nke esi esi mmiri ga-eme ka ekpomoku dị n'ime ụlọ ahụ kwesịrị ịgbakwunye karama ntụ ahụ, wee jiri mkpuchi kpuchie karama ahụ wee wụchaa ntụ ntụ kpamkpam, kwe ka karama ahụ kwụrụ ruo minit 5 iji hụ na ngwakọta zuru ezu. Tinye mmiri n’ime akara n’ime karama ahụ ma gbanye karama ahụ ọzọ. Na mkpokọta, a chọrọ ihe dị ka 92 ml mmiri iji kwadebe nkwusioru maka ọgwụ nke 125 mg + 31.25 mg na 64 ml mmiri maka usoro onunu ogwu nke 200 mg + 28.5 mg na 400 mg + 57 mg.

    Ekwesịrị imebi karama ahụ nke ọma tupu ojiji ọ bụla. Maka ịsingụ ọgwụ ọ accurateụ accurateụ ziri ezi, a ga-eji okpu eji atụ ahụ, nke a ga-eji mmiri wee saa ya nke ọma. Mgbe dilution, ekwesịrị ịchekwa nkwụsị ahụ ihe na-erughị ụbọchị 7 na friji, mana ọ bụghị kpọnwụrụ.

    Maka ụmụaka na-erubeghị afọ abụọ, a pụrụ iji mmiri gwọọ ntụtụ nke ọgwụ mgbochi Augmentin Aug na nke 1: 1.

    Dodoụbiga ya ókè

    Ọrịa enwere ike ihu ya site na eriri afọ na mgbakasị ahụ na nguzo mmiri-electrolyte.

    A kọwara amoxicillin crystalluria, n'ọnọdụ ụfọdụ na-eduga na mmepe nke ọdịda akwara (lee "Ntuziaka Pụrụ Iche").

    Ọrịa dị na ndị ọrịa nwere nsogbu gbasara akụrụngwa, yana ndị na-anata oke ọgwụ.

    Ọgwụgwọ: Mgbaàmà sitere na akwara eriri afọ - ọgwụgwọ ọrịa, na-a speciala ntị pụrụ iche n'ịgbazi mmiri-electrolyte. Enwere ike wepu Amoxicillin na clavulanic acid na ọbara ọbara site na hemodialysis.

    Nsonaazụ nke ọmụmụ a na-aga n'ihu nke emere ụmụaka 51 na etiti ọgwụ na-egbu egbu gosipụtara na nchịkwa nke amoxicillin na ọgwụ erughị 250 mg / n'arọ anaghị eduga mgbaàmà dị egwu ma ọ chọghị lavage gastric.

    Mpempe mwepụta

    Ntụ ntụ maka nkwụchi ọnụ, 125 mg + 31.25 mg na 5 ml. N'ime karama doro anya, kpuchie ya na okpu mkpuchi alumini nwere njikwa nke oghere mbụ, 11.5 g 1 fl. ya na okpu eji atunye ihe na kaadiboodu.

    Ntụ ntụ maka nkwadebe nke nkwusioru maka nchịkwa ọnụ, 200 mg + 28.5 mg na 5 ml, 400 mg + 57 mg na 5 ml. Na karama enyo enyo mechiri emechi mkpuchi alumini ahu nke nwere ikike imeghe mbu, 7.7 g (maka onunu ogwu nke 200 mg + 28.5 mg na 5 ml) ma obu 12.6 g (maka onunu ogwu nke 400 mg + 57 mg na 5 ml ) 1 fl. tinyere okpu eji atụ ma ọ bụ sirinji na igbe kaadi.

    Mbadamba ihe eji etinye fim, 250 mg + 125 mg. Na aluminom / PVC ọnya mkpụrụ 10 pcs. 1 ọnya na akpa nke silica na ngwugwu nke aluminium laminated. Mpempe akwụkwọ 2 mkpọ na igbe kaadi.

    Mbadamba ihe eji etinye fim, 500 mg + 125 mg. Na aluminom / PVC / PVDC ọnya 7 ma ọ bụ 10 PC. 1 ọnya na akpa nke silica na ngwugwu nke aluminium laminated. 2 ngwugwu nke aluminium lavu emere na igbe kaadi.

    Mbadamba ihe eji etinye fim, 850 mg + 125 mg. Na aluminom / PVC ọnya 7 pcs. 1 ọnya na akpa nke silica na ngwugwu nke aluminium laminated. Mpempe akwụkwọ 2 mkpọ na igbe kaadi.

    Emeputa

    SmithKlein Beach P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.

    Aha na adresị nke ụlọ ọrụ iwu nke aha ya nyere akwụkwọ ikike ndebanye aha ya: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.

    Maka ama ndị ọzọ, kpọtụrụ: GlaxoSmithKline Trading CJSC. 121614, Moscow, St. Krylatskaya, 17, bldg. 3, ala 5. Ogige Azụmaahịa "Ugwu Krylatsky."

    Ekwentị: (495) 777-89-00, faksị: (495) 777-89-04.

    Irationbọchị mmechi nke Augmentin

    mbadamba ihe mkpuchi fim 250 mg + 125 mg 250 mg + 125 - afọ 2.

    mbadamba ihe mkpuchi 500 mg + 125 mg - afọ 3.

    mbadamba ihe mkpuchi fim 875 mg + 125 mg - 3 afọ.

    ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 125mg + 31.25mg / 5ml - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

    ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

    ntụ ntụ maka nkwusioru maka nchịkwa ọnụ 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - afọ 2. Nkwado a kwadebere bụ ụbọchị asaa.

    Ejila oge emechara ka egosiputara na ngwugwu ahụ.

    Ngwakọta na ụdị ntọhapụ

    Anyị na-edepụta ụdị nke ịhapụ ọgwụ ndị edepụtara na Russia:

    1. Nhọrọ dị n'ụdị ntụ ntụ kpọrọ nkụ maka ịkwado nkwusioru ọnụ, nke nwere mgmg + mg + 31,25 na 5 ml nke ọgwụ a rụchara.
    2. Augmentin n'ụdị ntụ ọka kpọrọ nkụ maka ịkwadebe nkwusioru nke nwere ọgwụ mg nke 200 mg + 28.5 mg na 5 ml nke ọgwụ a rụchara.
    3. Augmentin ntụ ntụ nwere 400 mg + 57 mg na 5 ml nke nkwusiri ahụ emechiri,
    4. Augmentin ntụ ntụ, ezubere maka nkwadebe nke ihe ngwọta maka nchịkwa intraven.
    5. Augmentin ES ntụ ntụ maka ịkwadebe nkwusioru nke ụmụaka, nke nwere 600 mg + 42.9 mg na 5 ml,
    6. Mbadamba 500mg + 125mg
    7. Mbadamba 875 mg + 125 mg mbadamba
    8. Mbadamba Augmentin 250mg + 125 mg.

    Ndị na-ahụ maka ọgwụ na ọgwụ: ọgwụ nje nke penisillin buru ibu na-egbochi beta-lactamase inhibitor.

    Gịnị ka eji eme Augmentin?

    Dabere na ntuziaka Augmentin a na-eji maka nje ndị nje na-akpata microorganisms maara na ọgwụ ahụ. Ndị a gụnyere:

    1. Ọrịa nke akụkụ ENT - otitis media, tonsillitis, pharyngitis, sinusitis,
    2. Ọrịa bronchipulmonary na-efe efe: nnukwu bronchitis, njọ nke bronchitis na-adịghị ala ala, oyi baa,
    3. Ọrịa a na-adịghị akọwapụta nke usoro mkpụrụ ndụ: cystitis, pyelonephritis, urethritis, na ụmụ nwanyị - nje vulvovaginitis, endocervicitis,
    4. Akpịrị na anụ ahụ dị nro,
    5. Nnukwu ọnya afọ na - efe efe, salmonellosis,
    6. Ọrịa musculoskeletal - osteomyelitis, ụfọdụ ụdị ọrịa ogbu na nkwonkwo,
    7. Ọrịa ezé - ụkwara, ezé ezé,
    8. Ogwu akwara
    9. Sepsis.

    Ọzọkwa, ojiji nke Augmentin ka egosipụtara maka ọrịa na-efe efe na-esote oge ọmụmụ.


    Omume ọgwụ

    Ọgwụ nje dị iche iche. O nwere ihe nje na - akpata ahụhụ.Ọ na - arụ ọrụ megide oke ikuku aerobic (na - etolite na ọnụnọ oxygen) na anaerobic (nke enwere adị na enweghị oxygen) gram-good and aerobic microorganisms, gụnyere ụdị na - eke beta-lactamase (enzyme nke na - emebi penicillins).

    Clavulanic acid, nke bụ akụkụ nke nkwadebe ahụ, na-enye nguzogide nke amoxicillin na nsonaazụ beta-lactamases, na-agbasa ụdị dị iche iche nke omume ya.

    Ntụziaka maka ojiji

    Dabere na ntuziaka maka ojiji nke Augmentin, a na-ahazi usoro onunu ogwu n’otu n’otu dabere n’afọ, oke ahụ, ọrụ akụrụ nke onye ọrịa, yana ogo ọrịa ahụ. Ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume duziri ọgwụ (na mmalite ọgwụgwọ, parenteral management of the ọgwụ with sochiri transition to oral management).

    • Ndị okenye na ụmụaka karịrị afọ 12 ma ọ bụ na-eru 40 n'arọ ma ọ bụ karịa. 1 mbadamba 250 mg / 125 mg ugboro 3 / ụbọchị (maka oria dị nwayọ rue ogo oke), ma ọ bụ 1 mbadamba 500 mg / 125 mg ugboro 3 / ụbọchị, ma ọ bụ 1 mbadamba 875 mg / 125 mg 2 ugboro / ụbọchị, ma ọ bụ 11 ml nke nkwụsị nke 400 mg / 57 mg / 5 ml 2 ugboro / ụbọchị (nke ya na mbadamba 1 nke 875 mg / 125 mg).
    • Mbadamba 250 mg / 125 mg abụọ abụghị otu mbadamba 500 mg / 125 mg.
    • Umuaka site na onwa ato rue afo iri na abuo n’eji aru ya erughi kilogram 40. Edere ọgwụ ahụ n'ụdị nkwusioru maka nchịkwa ọnụ. A na-eme ngụkọta oge dabere na afọ na oke ahụ, nke egosipụtara na mg / kg body body / day (ịgbakọ dịka amoxicillin) ma ọ bụ na ml nke nkwusioru.
    • Umuaka site na omumu rue onwa ato. N'ihi ezumike nke akụrụ ahụ, ọgwụ a tụrụ aro ya nke Augmentin (gbakọọ dịka amoxicillin) bụ 30 mg / kg / ụbọchị na usoro ọgwụgwọ abụọ kewara n'ụdị nkwụsị 4: 1.

    Obere oge nke ọgwụ mgbochi bụ ụbọchị 5. Ọgwụ ekwesịghị ịga n’ihu karịa ụbọchị iri na anọ na-enweghị nyocha banyere ọnọdụ ụlọ ọgwụ. Iji were mee nke ọma ma belata nsonaazụ ndị enwere ike na sistemụ nri, a na-atụ aro Augmentin ka ebido n'isi nri.

    Augmentin n'oge afọ ime na lactation

    Dịka ọtụtụ ọgwụ mgbochi penisilini, amoxicillin, nke ekesara na anụ ahụ, na-abanyekwa na mmiri ara. Ọzọkwa, Chọpụta akụkụ nke clavulanic acid nwere ike ịchọta n'ime mmiri ara ehi.

    Agbanyeghị, ọ nweghị mmetụta dị njọ na ahụike ekwenyeghị na ọnọdụ nwatakịrị ahụ. N'ọnọdụ ụfọdụ, njikọta nke clavulanic acid na amoxicillin nwere ike bute afọ ọsịsa na / ma ọ bụ candidiasis (thrush) nke akpụkpọ ahụ mucous n'ime oghere olu nwa.

    Augmentin so n ’ụdị ọgwụ eji eme nwa ara. Ọ bụrụ, n'agbanyeghị nke a, ka usoro ọgwụgwọ nne na -eme ya na Augmentin, nwatakịrị ahụ nwere ụfọdụ nsonaazụ na-adịghị mma, na-akwụsị inye nwa ara.

    Analogs nke Augmentin bụ A-Clav-Farmex, Amoxiclav, Amoxil-K, Betaclav, Clavamitin, Medoclav, nkwadebe Teraclav.

    Ntị: iji ọgwụ ike ana-ekwenye ekwenye na dọkịta na-ahụ maka ịga.

    Ọnụ ego Augmentin dị na ụlọ ahịa ọgwụ (Moscow) dabere n'ụdị ntọhapụ.

    1. Mbadamba Augmentin 250 mg + 125 mg, 20 PC. - site na 261 rub.
    2. Mbadamba Augmentin 500 mg + 125 mg, 14 PC. - site na 370 rub.
    3. Mbadamba Augmentin 875 mg + 125 mg, 14 PC. - site na 350 ite.

    Usoro na ọnọdụ nchekwa

    Ekwesịrị ịchekwa ọgwụ a na ebe akọrọ na ụmụaka agaghị enweta ya na okpomọkụ na-agaghị eru ogo 25 Celsius. Ndụ nchekwa nke mbadamba (250 mg + 125 mg) na (875 mg + 125 mg) bụ afọ 2, na mbadamba (500 mg + 125 mg) bụ afọ 3. Ndụ nchekwa nke ntụ ntụ maka ịkwadebe nkwusioru n'ime karama na-emebeghị emeghe bụ afọ 2.

    Ekwesịrị ịchekwa nkwusioru a kwadebere na friji na okpomọkụ nke 2 Celsius ruo 8 Celsius maka ụbọchị asaa.

    Ahapụ Gị Ikwu

    https://pobedidijabetes.org

    Popular Posts

    pobedidijabetes.org © Copyright 2024. All Rights Reserved. | Imeri Ọrịa shuga!