Lozarel Plus > Ọgwụgwọ na mgbochi

Lozarel Plus: ntuziaka maka ojiji na nyocha

Aha Latin: Losarel Plus

Koodu ATX: C09DA01

Ngwakọta ọrụ: hydrochlorothiazide (Hydrochlorothiazide) + losartan (Losartanum)

Emeputa: LEK dd (LEK d.d.) (Slovenia)

Nkọwa na nwelite: 11.28.2018

Ego dị n'ụlọ ahịa ọgwụ: site na 120 rubles.

Lozarel Plus bụ ọgwụ ejikọtara ọnụ.

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe usoro onunu ogwu - mbadamba ihe eji eme ihe nkiri: okirikiri, biconvex, na odo odo gbara agba, nke nwere isi di ocha site na ocha di ocha na acha ocha (n’ime kaadiboodu nke mbu nke 3-6, 8, 10 ma obu 14 puru iche. mbadamba, na ntuziaka maka iji Lozarel Plus).

Nhazi nke 1 mbadamba (12.5 mg + 50 mg) / (25 mg + 100 mg) gụnyere:

bekee na-arụ ọrụ: hydrochlorothiazide - 12.5 / 25 mg, potassium losartan - 50/100 mg (gụnyere losartan - 45.8 / 91.6 mg na potassium - 4.24 / 8.48 mg),
ihe inyeaka (isi): microcrystalline cellulose - 60/120 mg, lactose monohydrate - 26.9 / 53.8 mg, pregelatinized stachi - 23.6 / 47.2 mg, colloidal silicon dioxide - 0,5 / 1 mg, stearate magnesium - 1.5 / 3 mg,
mkpuchi ihe nkiri: hyprolose - 1.925 / 3.85 mg, hypromellose - 1.925 / 3.85 mg, titanium dioxide - 1.13 / 2.26 mg, ncha iron oxide odo - 0.02 / 0.04 mg.

Ngwongwo ogwu

Lozarel Plus bụ ngwakọta nke losartan (onye antagonistin II na-anabata angiotensin II) na hydrochlorothiazide (thiazide diuretic). Nchikota nke ihe ndia nwere uto antihypertensive ma wedata obara mgbali elu (obara obara) na odi uku ma e jiri ya mee ihe ndia dika monotherapy.

Mmetụta hypotensive nke Lozarel Plus na-adịgide ruo awa 24, a na-ejikarị ọgwụgwọ kachasị na-enweta n'ime izu anọ nke nnabata.

Mlọ ọgwụ

Losartan bụ otu n'ime ndị na - emegide ụzọ nnabata angiotensin II (ụdị AT1). Mgbe nchịkwa ya gasịrị, angiotensin II na-ejikọ aka na ndị na-anabata AT1 dị na akwara dị iche iche (na adrenal gland, mkpụrụ ndụ akwara dị mma nke akwara ọbara, obi na akụrụ), na ọtụtụ ọrụ ndu dị mkpa, gụnyere ntọhapụ nke aldosterone na vasoconstriction. Angiotensin II na - akpalitekwa ịbawanye uru akwara dị mma.

Dabere na nsonaazụ nke ọmụmụ a, losartan na metabolic E-3174, na-egosi ọrụ ọgwụ, na-egbochi mmetụta physiological nke angiotensin II, n'agbanyeghị isi iyi ma ọ bụ ụzọ biosynthesis ya.

Losartan ACE (angiotensin na-agbanwe enzyme), nke anaghị egbochi kininase nke abụọ, yana, n'ihi ya, anaghị egbochi mbibi nke bradykinin. Ya mere, mmeghachi omume na-adịghị mma nke ejikọtara na bradykinin (karịchaa, angioedema) dị ụkọ. Losartan na metabolite na-arụ ọrụ ya nwere mmekọrịta dị ukwuu maka ndị na-anabata angiotensin m karịa maka ndị na-anabata angiotensin II. Metabolite na-arụ ọrụ nke losartan na-arụ ọrụ karịa ihe ahụ, ihe dị ka ugboro 10-40. Ihe Plasma nke losartan na metabolite na-arụ ọrụ n'ime ọbara, yana mmetụta antihypertensive nke ihe ahụ na-abawanye dabere na dose nke Losarel Plus. Ebe ọ bụ na losartan na metabolite ya na-arụ ọrụ bụ ndị na-emegide nnabata angiotensin II, ha abụọ na-enye aka na mmetụta hypotensive.

Isi mmetụta nke losartan na metabolite ya bụ E-3174:

mbelata ọbara mgbali elu na mgbali na mgbasa akwara, mbelata ngụkọta ngụgụ nke akwara ọbara na ịta aldosterone n'ọbara.
ebidolata mbelata
inye onyinye diuretic,
igbochi mmepe nke hypertrophy myocardial,
ịba ụba nnabata mmega ahụ maka ndị ọrịa nwere nkụda obi (obi anaghị ala ala),
nguzogide plasma na urea n'ọbara.

Ma losartan na metabolite ya na-arụ ọrụ anaghị emetụta mgbanwe nke ahịhịa; ha anaghị enwe mmetụta ogologo oge na mkpokọta plasma nke norepinephrine n'ime ọbara.

Mmetụta antihypertensive (n'ụdị mbelata systolic na ọbara mgbali) mgbe otu nchịkwa ọnụ na-erite uru kachasị na 6 awa, mgbe ahụ mmetụta ahụ na-agbadata karịa awa 24. Mmetụta antihypertensive kachasị na-amalite mgbe izu 3-6 nke ọgwụgwọ gasịrị.

Dika etolite na nnwale nke ulo ogwu a na-ejide n'aka ndi oria nwere nsogbu obara obara di nfe na ogwe aka, a na-ahuta onu ogugu na -akpata obara systolic na diastolic obara n'ihi iwere losartan otu ugboro ubochi. Mgbe atụnyere ọbara mgbali tụọ 5-6 na awa 24 mgbe ịwachara otu ọgwụ nke Lozarel Plus, achọpụtara na ka ị na-ejigide ụda ahụ kwa ụbọchị, ọbara mgbali na-adị ala maka awa 24. Na ngwụsị nke oge dosing, mbelata ọbara mgbali elu bụ ihe dịka 70-80% nke mmetụta a na-ahụ 5-6 awa mgbe nchịkwa ọnụ nke losartan.

Mgbe ndị ọrịa na-arịa ọbara mgbali elu na-akwụsịlata losartan, ọ naghị achọpụta mmụba dị elu na ọbara mgbali (wepu syndrome). Ihe a, agbanyeghi na akpọlata mgbali ọbara, ọ naghị enwe mmetụta dị oke egwu na ọnọdụ obi.

Ọgwụgwọ ọgwụgwọ nke losartan adịghị adabere na nwoke na nwanyị na afọ onye ọrịa.

Hydrochlorothiazide

Hydrochlorothiazide bụ thiazide diuretic. Ihe kachasị emetụta ya bụ mmebi nke reabsorption nke chlorine, sodium, magnesium na potassium ion dị na nephron distal, na-enyere aka igbu oge na excretion nke uric acid na calcium. Site na mmụba nke mkpịsị akwara nke ion ndị a, a na-achọpụta mmụba nke mmamịrị (n'ihi osmotic nke mmiri).

Ihe ahụ na-ebelata olu plasma ọbara, ma ọrụ renin na plasma ọbara na-abawanye ma na-eme ka biosynthesis nke aldosterone dịkwuo elu. Hydrochlorothiazide na usoro onunu ogwu na - enye aka na mmụba nke bicarbonates, na iji ogologo oge - iji belata mpụta nke calcium. Mmetụta antihypertensive na-etolite n'ihi mbelata olu nke ọbara na-erugharị, mgbanwe na arụmọrụ nke mgbidi vaskụla, mbelata mmetụta nke vasoconstrictive amines (adrenaline, norepinephrine) na mmụba nke mmetụta na-akụda mmụọ na ganglia. Ihe ahụ anaghị emetụta ọbara mgbali nkịtị. A na-ahụ mmetụta diuretic ahụ n'ime awa 1-2, uto kachasị na-etolite n'ime awa anọ, oge nke mmetụta diuretic ahụ bụ site na 6 ruo 12 awa.

Mmetụta ọgwụgwọ na-apụta mgbe ụbọchị nchịkwa 3-4 gachara, mana ọ na-ewe site na izu atọ ruo izu anọ iji rụpụta oke elele hypotensive.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, losartan na-etinye obi gị dum na eriri afọ. Ọ bụ metabolized n'oge akụkụ mbụ site na imeju site na mmanụ ụgbọ mmiri na ntinye nke cytochrome CYP2C9 isoenzyme, na nguzobe nke metabolite na-arụ ọrụ. Usoro bioavailability dị ihe dịka 33%. Iri nri anaghị emetụta ihe ngosi a. Oge iru C_max (losartan kachasi) nke losartan yana metabolite na-arụ ọrụ na ọbara ọbara mgbe nchịkwa ọnụ - 1 na elekere 3-4.

Mkpụrụ ahụ na metabolite ya na-arụ ọrụ na-ejikọ protein protein na ọkwa nke ihe karịrị 99%, tumadi na albumin. Ise_d (olu ekesa) bu lita 34. Losartan fọrọ nke nta ka ọ ghara ịbanye n'ime mgbochi ụbụrụ.

Mgbanwe nke ọgwụ pharmacokinetic nke ihe ahụ na metabolite ya na-arụ ọrụ mgbe ọ nwesịrị ihe dịka 200 mg nke losartan dị na ahịrị kwekọrọ na ọgwụ a .ụrụ.

Site na usoro nlekọta nke otu oge kwa ụbọchị, a naghị ahụkarị nchịkọta losartan na metabolite ya na plasma ọbara. Otu ihe ị aụ ọgwụ kwa ụbọchị nke 100 mg anaghị eme ka nchịkọta ihe dị ukwuu yana metabolites ya na plasma ọbara.

Ihe dịka 4% nke losartan ka a gbanwere na metabolite na-arụ ọrụ. Mgbe abatasịrị akara 14 C na losartan, a na-ejikọta ụzarị redio nke plasma ọbara na mbụ na ọnụnọ nke ihe na metaboliti na-arụ ọrụ n'ime ya. N'ihe dị ka 1% nke ikpe, a na-achọpụta ọkwa dị ala nke losartan metabolism.

Plasma na mkpochapu ya bụ (n’otu n’otu): losartan - ihe dịka 600 na 74 ml / min, metabolite na - arụ ọrụ ya - ihe dịka 50 na 26 ml / min. Ihe dị ka 4% nke losartan bụ akụrụ na-agbanwegharịghị, ihe dịka 6% - dị ka metabolite na-arụ ọrụ. Ọkpụkpọ Plasma nke ihe ahụ na metabolite ya na-arụ ọrụ na-agbada nke ukwuu na T ikpeazụ_1/2 (iwepu ọkara ndụ) maka elekere 2 na 6–9, nke ọ bụla. A na-ebupụ iwepụta akụrụ site na akụrụ na bile. Mgbe enwetachara akara 14 C nke losartan, ihe dị 58% nke redioacac dị na feces, 35% na mmamịrị.

Na-emegide nzụlite ịdị nro na-egbu egbu na-egbu egbu na-egbu egbu, ma e jiri ya tụnyere ndị ọrụ afọ ofufo mara mma, ịta ahụ nke losartan na metabolite na-arụ ọrụ na-abawanye site na oge 5 na 1.7 n'otu n'otu.

Ntinye uche nke losartan na plasma ọbara na CC (mwepu nke creatinine) nke dị 10 ml / min adịghị iche na nke ahụ na enweghị ọrụ ezigharị adịghị arụ ọrụ. N'ime ndị ọrịa ịba n'ọbara, uru nke AUC (mpaghara dị n'okpuru usoro ịta ahụhụ) ruru ihe dị okpukpu 2 karịa karịa na ezughi oke ọrụ ezumike. Site na iji hemodialysis, a na-ewepụ adịghị losartan na metabolite na-arụ ọrụ ya.

N'ime ụmụ nwanyị nwere ọbara ọgbụgba, uru nke plasma nke losartan karịrị ụkpụrụ kwekọrọ na ụmụ nwoke site na ihe abụọ, ebe ụmụ nwoke na ụmụ nwanyị itinye uche nke metabolite nọ n'ọrụ adịghị iche. Ọdịiche ụlọ ọrụ ọgwụ enweghị ihe ọhụụ.

Ihe ngbanwe

nnukwu nsogbu gbasara akụrụ (na ndị ọrịa nwere CC ihe na-erughị 30 ml / min),
oke imeju (dika nwatakiri si dị - ihe ọ Drinkụ Drinkụ, karịa isi 9),
ngbaka
ụkọ lactase, ọrịa malabsorption na ị andụ lactose,
Ọrịa Addison
golf nke nje na / ma ọ bụ hyperuricemia,
hyperkolemia refractory hyper, na hypokalemia, hypercalcemia, hyponatremia refract,
akpịrị ịkpọ nkụ, tinyere ihe ndị metụtara ya na iji ọgwụ ụkwara ume ọkụ dị ukwuu,
siri ike ịchịkwa ọrịa shuga
nnukwu ike ọgwụgwụ ọbara,
ngwakọta ọgwụgwọ na aliskiren na ọgwụ aliskiren nwere ọrịa n'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa (ya na ọnụego afọ abụọ) na / ma ọ bụ ọrịa shuga,
ime na lactation,
afọ ruo afọ 18
mmadụ ekweghị n'ihe ọ bụla mejupụtara ọgwụ ahụ, yana ọgwụ ndị sitere na sulfonamide.

Edebere (Lozarel Plus nọ n'okpuru nlekọta ahụike):

ngwakọta ọgwụgwọ na ọgwụ mgbochi mkpali na - abụghị steroidal (gụnyere ọgwụ mgbochi cyclooxygenase-2),
ụkọ ụkọ,
imebi mmiri ọbara ele ihe anya, dịka ọmụmaatụ, metụtara ọgbụgbọ ma ọ bụ ọria (hyponatremia, hypomagnesemia, hypochloremic alkalosis),
Stenosis abụọ akụrụngwa akwara ma ọ bụ stenosis nke otu akụrụ,
odida gbasara akụrụngwa (na ndị ọrịa nwere CC 30-50 ml / min),
Ibu akụkọ banyere ihe mgbu na ụkwara ume ọkụ,
ọrịa ọrịa imeju na-aga n'ihu na ọrụ ịba ọcha n'anya (dịka ọnụ ọgụgụ ụmụaka-Pugh, erughị isi 9),
systemic ọrịa nke anụ ahụ jikọrọ ọnụ (gụnyere systemic lupus erythematosus),
nkụda obi na ihe egwu na-egbu ndụ,
stenosis nke aorta ma ọ bụ mitral valve,
nnukwu myopia na nsochi akụkụ-emechi glaucoma (ejikọtara ya na hydrochlorothiazide),
akwara obi
ike obara nke obara,
hyperaldosteronism,
Ọnọdụ mgbe akụrụ akụrụ (enweghị ahụmị iji ya),
ọrịa shuga mellitus
so na ndị isi ojii.

Nsonaazụ

N'ime ule nke ụlọ ọgwụ na losartan na hydrochlorothiazide, a hụghị mmeghachi omume ọjọọ nke ọgwụ a jikọtara ọnụ.

Nsonaazụ ndị naanị pere aka maka ndị akọgoro mgbe ị na-eji ihe eji eme ihe nke Losarel Plus dịka monotherapy. Na mkpokọta, ugboro ugboro nke oghom mmetụta nke a jikọtara ya na nke a jikọtara ya na placebo.

N'ozuzu, a na-anabata ọgwụ nkwonkwo na losartan na hydrochlorothiazide. N'ọtụtụ oge, mmeghachi omume na-emebi emebi dị nwayọọ, dị mkpụmkpụ na ọdịdị ma ghara eduga na mkpochapu Lozarel Plus.

Dabere na nsonaazụ nke ọnwụnwa ụlọ ọgwụ a na-achịkwa, na ọgwụgwọ nke ọbara ọgbụgba dị oke mkpa, naanị mmeghachi omume na-adịghị mma nke metụtara njikwa Lozarel Plus, ugboro ole nke gafere karịa nke nwere paseeji karịa 1%, bụ ọgbụgbọ.

Ọzọkwa, mgbe a na-eduzi ọmụmụ ihe, achọpụtara na na ndị ọrịa nwere mgbali elu ventricular na mgbali elu akwara, nsogbu ndị a na-ahụkarị bụ: ike ọgwụgwụ, adịghị ike, systemic / non-systemic dizziness.

N'ime usoro ọmụmụ dị iche iche, gụnyere nyocha nke ndebanye aha, a na-edekọ mmetụta ndị a na - eso> 10% - ọtụtụ mgbe (> 1% na 0.1% na 0.01% na 5.5 mmol / L), ugboro ugboro - mmụba na serum urea ịta. / nri nitrogen na creatinine n'ime ọbara, hyperbilirubinemia dịkarịsịrị nta, mmụba na arụ ọrụ hepatic transaminases (aspartate aminotransferase na alanine aminotransferase), na-enwekarị oge - hyponatremia,

nkwarụ izugbe: mgbe mgbe - ike ọgwụgwụ, asthenia, ọrịa akụkụ, ihe mgbu na mpaghara obi, adịghị ala ala - ahụ ọkụ na-efegharị nke ihu, yana oge na - enweghị atụ - ihe mgbaàmà dị ka ọrịa, ịba.

Ihe mmebi omume puru iche sitere na sisitemu na akwara n'ihi hydrochlorothiazide:

sisitemu obi: akaghi aka - orthostatic hypotension, arrhythmias, vasculitis,
sistem nri: enweghi oge - mgbakasị ahụ mucosa, cholestatic jaundice, intrahepatic cholestasis, cholecystitis ma ọ bụ pancreatitis, afọ ọsịsa, ọgbụgbọ, ọgbụgbọ, ihe nrịbama, afọ ntachi, sialadenitis, anorexia,
sis urinary system: infrequently - interstitial nephisis, gbasara akụrụ, ọrụ ezughi oke ọrụ,
sistemu ụjọ: mgbe ụfọdụ - isi ọwụwa, ugboro ugboro - akpịrị ọgbụgba, paresthesia, ehighị ụra,
usoro ahụ ji alụso ọrịa ọgụ: na - adịghị ala ala - nsogbu iku ume (gụnyere ọrịa obi na - adịghị ala ala), urticaria, necrotic vasculitis, purpura, Stevens-Johnson syndrome, adịkarịghị - mmeghachi omume anaphylactic, ikekwe na-ama jijiji,
ọbara na sistem lymphatic: obere oge - thrombocytopenia, leukopenia, agranulocytosis, aplastic / hemolytic anemia,
akụkụ nke ọhụụ: ugboro ugboro - xantopsia, ọhụhụ na-adị nwa oge, yana oge na-enweghị njedebe - glaucoma dị nkenke,
anụ ahụ na nke anụ ahụ dị n'okpuru ala: ugboro ugboro - necrolysis na-egbu egbu, fotoensitivity, nwere ugboro ugboro - lupus erythematosus,
metabolism na oriri na-edozi: ugboro ugboro - hypomagnesemia, hypokalemia, hyperglycemia, hyponatremia, glucosuria, hyperuricemia na mmepe nke mwakpo nke gout, hypercalcemia na hypochloremic alkalosis (gosipụtara n'ụdị xerostomia, akpịrị ịkpọ nkụ, obi akwara obi / ọnọdụ akwara, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ pụrụ iche ma ọ bụ adịghị ike, hypochloremic alkalosis nwere ike iduga mmepe nke hepatic encephalopathy / hepatic coma), hyponatremia (gosipụtara dị ka ọgba aghara, nkwarụ , Lethargy, onye na-adịghị eche echiche usoro, excitability, ike ọgwụgwụ, muscle cramps) n'oge ọgwụ thiazide ikekwe isi glucose ndidi, na-eru na ike gosi latent-arịa ọrịa shuga mellitus, na ihe banyere nke elu doses nwere ike dịkwuo ọbara ịta nke lipids na ọbara,
ndị ọzọ: oge na - adịghị adị - akpụ akpụ, ike ha belatara.

Dodoụbiga ya ókè

Ihe mgbaàmà nke oke nnyefere nke ihe ndị na-arụ ọrụ nke Lozarel Plus:

losartan: tachycardia, mbelata ọbara mgbali elu, bradycardia (nke metụtara mkpali vagal),
hydrochlorothiazide: mfu nke electrolytes (n'ụdị hypokalemia, hyperchloremia, hyponatremia), yana akpịrị ịkpọ nkụ, nke na-etolite n'ihi oke ibu, n'ihe metụtara ojiji a na-eji glycosides cardiac, hypokalemia nwere ike ime ka iwe nke arrhythmias ka njọ.

Usoro ọgwụgwọ: na-akwado ma na akara. Y’oburu na obere oge agafele n’ oriri nnabata, ikwesiri itucha afo, dika ihe ngosi si di, a gha emezi nsogbu diri mmiri. Losartan na metabolites ya na-arụ ọrụ adịghị ewepụ hemodialysis.

Mpempe usoro onunu ogwu

Mbadamba ihe eji etinye ihe nkiri 50 mg / 12.5 mg, 100 mg / 25 mg

Otu mbadamba ihe

bekee na-arụ ọrụ: losartan potassium 50 mg, hydrochlorothiazide 12.5 mg ma ọ bụ

losartan potassium 100 mg, hydrochlorothiazide 25 mg

ndị na-ahụkarị: lactose monohydrate, microcrystalline cellulose, sitara pregelatinized, magnesium stearate, anhydrous colloidal silicon dioxide.

ihe mejupụtara shei: hypromellose, hydroxypropyl cellulose, odo iron oxide (E 172), titanium dioxide (E 171), macrogol (400) (maka onunu ogwu nke 100 mg / 25 mg), talc (maka onunu ogwu nke 100 mg / 25 mg).

Mbadamba ihe eji etinye ihe nkiri, odo edo edo na agba, gbaa gburugburu, na-eji biconvex elu.

Usoro onunu ogwu na nhazi

Enwere ike idenye Lozarel Plus na njikọ ndị ọzọ na - egbochi ọgwụ mgbochi.

Ekwesịrị iji ọnụ na iko dị mbadamba ọnụ, n'agbanyeghị nri.

A nabataghị potassium posartan na hydrochlorothiazide dị ka usoro ọgwụgwọ mbụ, mana ka enyere ndị ọrịa aka na ojiji nke losartan potassium ma ọ bụ hydrochlorothiazide iche anaghị eduga na nchịkwa zuru oke nke ọbara mgbali.

A na-atụ aro ka itinye otu ụzọ maka ụzọ abụọ ọ bụla (potassium losartan na hydrochlorothiazide).

Mgbe ọ dị mkpa maka ọgwụgwọ, na ndị ọrịa nke anaghị achịkwa ọbara ọbara nke ọma, enwere ike ịtụle mgbanwe mgbanwe nke monotherapy na njikọta nke ọ bụla.

Lozarel Plus 50 mg / 12.5 mg ihe eji eme ihe nkiri

Ọgwụ mmezi a na-enwekarị: 1 mbadamba 50 mg / 12.5 mg 1 oge kwa ụbọchị.

Maka ndị ọrịa na-enweghị azịza zuru oke, enwere ike ịbawanye dose ahụ gaa mbadamba 2 nke 50 mg / 12.5 mg otu ugboro n'ụbọchị ma ọ bụ mbadamba 1 nke 100 mg / 25 mg otu ugboro n'ụbọchị.

Dịka iwu, a na-enweta mmetụta antihypertensive n'ime izu 3-4 mgbe mmalite nke ọgwụgwọ.

Lozarel Plus, mbadamba ihe mkpuchi fim 100 mg / 25 mg Mpekere kacha nta: 1 mbadamba 100 mg / 25 mg otu ugboro n'ụbọchị.

Dịka iwu, a na-enweta mmetụta antihypertensive n'ime izu 3-4 mgbe mmalite nke ọgwụgwọ.

Jiri na ndị ọrịa nwere nsogbu gbasara akụrụngwa na-arịa ọrịa na n'ọrịa ya na n'ọbara.

N'ime ndị ọrịa nwere ọrụ mkpado na-arụ ọrụ nke ukwuu (ya bụ, mwepụ nke creatinine bụ 30-50 ml / min), a chọghị mgbanwe mgbanwe dose mbụ. Agaghị atụkọta ngwakọta nke losartan-hydrochlorothiazide na ndị ọrịa na hemodialysis. Ekwesighi inye ndokpo nke losartan-hydrochlorothiazide nye ndị ọrịa nwere nnukwu ọrụ mkpo ya (ikike ihie ya.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, oge 1 kwa ụbọchị, n'agbanyeghị nri nri.

Site n'ọbara mgbali elu, ụzọ mbụ a na-esi elele ọgwụ ahụ bụ 1 tab. LozarelR Plus 12.5 mg + 50 mg / ụbọchị.

Na enweghị mmetụta ọgwụgwọ zuru oke n'ime izu 3-4, ekwesịrị ịbawanye dose ahụ na mbadamba 2 nke LozarelR Plus 12.5 mg + 50 mg ma ọ bụ mbadamba 1 nke LozarelR Plus 25 mg + 100 mg (ọgwụ kachasị kwa ụbọchị).

N'ime ndị ọrịa nwere oke ọbara na-agagharị agagharị (dịka ọmụmaatụ, mgbe ị na-a largeụ ọgwụ ọ diụ largeụ buru ibu), ọgwụ a na-atụ aro ka losartan bụ 25 mg otu ugboro n'ụbọchị. N'akụkụ a, ekwesịrị ịmalite ọgwụgwọ LozarelR Plus mgbe akagbuola mgbatị ahụ ma mezie hypovolemia.

N'ime ndị ọrịa agadi na ndị ọrịa nwere nsogbu gbasara obere akwara, gụnyere ndị nwere ọrịa diaal, ọ nweghị ndozi ọgwụ achọrọ ka achọrọ.

Omume ọgwụ

Lozarel Plus bụ ngwakọta nke antagonist II nke na-anabata antagonist (losartan) na thiazide diuretic (hydrochlorothiazide). Nchikota nke ihe ndi a nwere uto ihe anakpo antihypertensive ma belata obara mgbali elu (BP) karie ihe ndi ozo n’otu iche.

Mmekorita

Site n'iji thiazide diuretics n’otu oge na barbiturates, narcotic analgesics, ethanol, ihe ọghọm nke ịmalite hypotension orthostatic ga-ekwe omume.

Diuretics belata nhichapu nke lithium ma bulie ohere nke nsonaazụ ya, a na-atụ aro ijikọ ọnụ maka nkwadebe na lithium.

Iji otu oge iji na amines pressor (norepinephrine, epinephrine), mbelata ntakịrị na nsonaazụ nke amines pressor, enwere ike itinye aka na nchịkwa ha, na-enweghị depolarizing muscle relaxants (tubocurarine) - mmụba na mmetụta ha.

Site na iji glucocorticosteroids, hormone adrenocorticotropic (ACTH), ọ ga-ekwe omume ịbawanye ọnwụ nke electrolytes, na-eme ka hypokalemia ka njọ. Thiazides nwere ike belata mkpụrụ ndụ akwara nke ọgwụ cytotoxic ma welie mmetụta myelosuppressive ha.

Ntụziaka pụrụ iche

Ọgwụ ndị nwere mmetụta na RAAS (renin-angiotensin-aldosterone system) n’ime ndị ọrịa nwere akwara mkpụrụ ndụ akwara ma ọ bụ stenosis nke akwara akwara nwere ike ime ka urea na ọbara mepụta ọbara. Achọpụtara ụdị mmetụta ndị a na losartan. A na - agbanwegharị mkpụrụ ndụ ezighi ezi ndị a ma gafere mgbe ha kwụsịrị ọgwụgwọ. Enwere ihe akaebe na n'ụfọdụ ndị ọrịa na-a theụ ọgwụ ahụ, mgbanwe ndị gbanwere n'ọrụ ọrụ akụrụ, gụnyere ọdịda akụrụ, mere n'ihi mkpochapụ ọrụ RAAS.

Dị ka iji ọgwụ ndị ọzọ nwere mmetụta dị egwu, n'ihi mbelata ọbara mgbali elu na ọrịa ụbụrụ ischemic, ọrịa ụbụrụ myocardial na ọrịa strok nwere ike ịmalite.

N'ime ndị ọrịa nwere nkụda mmụọ na / na-enweghị ọrụ akụrụngwa arụ, nnukwu akụrụ oke ume na mbelata ọbara mgbali ga-ekwe omume.

Dịka ndị ọzọ na-anabata angiotensin II antagonists, losartan adịkarịghị arụ ọrụ na ndị ọrịa agbụrụ Negroid, nke metụtara ọrụ renin dị ala.

N'ime ndị ọrịa mgbe a gbasesịrị akụrụ, enweghị ahụmịhe n'iji losartan.

1. Ihe ngosi maka iji

Edere ọgwụ Lozarel ma ọ bụrụ na enwere:

Ihe doro anya ihe ịrịba ama nke ọbara mgbali elu.
Mbelata ihe ize ndụ nke ọrịa obi na akwara na ndị mmadụ na-arịa ọbara mgbali elu ma ọ bụ mgbali elu ventricular aka ekpe, nke a na-egosipụta site na mbelata ọnụ ọgụgụ ọrịa obi, ọrịa strok na infarction ụbụrụ.
Inye nchedo akụrụ n’ime ndị ọrịa nwere ụdị shuga 2.
Mkpa belata proteinuria.
Ọrịa obi na-adịghị ala ala na ọdịda ọgwụgwọ site na ndị na - egbochi ACE.

3. Mmekọrịta Ọgwụ

Mmekorita nke Lazorel na ogwu ndi ozo:

Enweghi mmekorita di na Lozarel na Hydrochlorothiazide na Digoxin, yana ogwu ndi ozo nwere aru di otua. Mgbe ụfọdụ ijikọ ya na "Rifampicin" na "Fluconazole" na-eduga n'ịbelata ọkwa nke metabolite na-arụ ọrụ na plasma ọbara.
Njikọ ya na ọgwụ na-egbochi enzyme angiotensin II ma ọ bụ ihe ọ na-eme, enwere mmụba dị ukwuu na ihe egwu nke hyperkalemia.
Ọgwụ mgbochi anaghị agwọ ọrịa nwere ike belata arụmọrụ nke ndị na - anabata angiotensin II.
Ejikọtara ọnụ na antiotensin II antagonists na NSAID na-ebute nsogbu akụrụ.
Njikọ nke ndị na-anabata angiotensin II na ndị na-anabata lithium na-akpata mmụba na ụba lithium dị na plasma ọbara.
Ọgwụgwọ "Losarel" n'otu oge na iwebata diuretics na-enye mmụba. N'ihi ya, enwere mmụba ọnụ na arụmọrụ ọgwụ dị iche iche.

6. Usoro na ọnọdụ nchekwa

Na-echekwa na okpomọkụ agaghị akarị 25 Celsius. Debe ọgwụ ahụ ka ụmụaka ghara iru ya.

Exbọchị mmebi Ọgwụ bụ afọ 2.

Ejila ọgwụ ahụ mgbe ọ gwụchara.

Ọnụ ọnụ ọgwụ ọgwụ Lazorel dịgasị dabere na onye nrụpụta na netwọ nke ụlọ ahịa ọgwụ. na Russia na nkezi ọ na-efu site na 200 rubles.

Na Ukraine ọgwụ ahụ agbasaghị ebe niile ma na-efu ihe dịka 200 UAH.

Ọ bụrụ na ọ dị mkpa, ịnwere iji ọgwụ ọgwụ ndị a dochie "Lozarel":

Brozaar
Ngọngọ
Vero-Losartan
Vazotens
Cardomin-Sanovel
Zisakar
Cozaar
Karzartan
Lozap,
Lakea
Losartan A,
Losartan Canon
"Losartan potassium",
Losartan Richter,
Losartan MacLeods,
Losartan Teva
"Lozartan-TAD",
Losacor
Lorista
Presartan
Lotor
"Renicard."

Iji ọgwụ analorọ maka ọgwụgwọ ka achọrọ karịsịa n'ọnọdụ ebe onye ọrịa ahụ nwere nnabata onwe ya na ọgwụ ahụ. Agbanyeghị, naanị dọkịta nwere ike inye gị ọgwụ ọ bụla.

Enwere ike ịchọta nyocha nke ọgwụ ahụ na Internetntanetị, dịka ọmụmaatụ, Anastasia dere, sị: “Ọrịa shuga m na-akpata oke nhụjuanya. N’oge na-adịghị anya, achọtara m ihe ngosipụta ọhụrụ nke ọrịa a. Achọpụtara m na nephropathy. Dọkịta ahụ nyere ọtụtụ ọgwụ dị iche iche, gụnyere Lozarel. Ọ bụ ya nyeere aka weghachi ọrụ akụrụ niile na-arụ ọrụ nke ọma. Ọkpụkpụ ụkwụ adịghịzị apụ. ”

Enwere ike ịchọta nyocha ndị ọzọ na njedebe nke edemede a.

A ghọtara Lozarel ọgwụ dị ka ọgwụ dị irè na ọgwụgwọ ọbara mgbali elu na nkụchi obi. O nwere usoro analogues na-agbasawanye nke nwere nnukwu ihe mejupụtara ya, a naghị akwado ya maka nsogbu nke imeju na akụrụ, yana n'oge afọ ime na n'okpuru afọ 18. Iji zere ihe ndị ga - eme, a na - atụ aro ka ị theụ ọgwụ ahụ nke ọma dịka dọkịta nyere n'iwu.

Mbadamba ụrọ, ihe mkpuchi na-acha ọcha ma ọ bụ na-acha ọcha nwere agba na-acha odo odo, okirikiri, biconvex, nwere ihe ize ndụ n'otu akụkụ.

Ndị na-ahụ maka ihe: microcrystalline cellulose, lactose monohydrate, stgelatinized sitter, anhydrous colloidal silicon dioxide, magnesium stearate.

Ngwakọta nke akpụkpọ ahụ ihe nkiri: hypromellose, hyprolose, macrogol 400, titanium dioxide (E171), talc.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.

Ọgwụ antihypertensive, onye na - ahọpụta onye na - anabata angiotensin II (ụdị AT 1). Angiotensin II na - ejikọ aka na ndị na - anabata AT 1 ndị a hụrụ n'ọtụtụ anụ ahụ (na akwara olu nke akwara ọbara, akwara na obi) ma na - akpata vasoconstriction na ntọhapụ aldosterone, ịba ụba akwara.

Na vitro na nyocha nke vivo egosila na losartan na metabolcologically na-arụ ọrụ metabolite na-egbochi mmetụta physiologically dị mkpa nke angiotensin II, n'agbanyeghị isi iyi ma ọ bụ ụzọ nke njikọ ya. Ọ naghị egbochi kinase II - enzyme nke na-ebibi bradykinin.

Ọ na-ebelata OPSS, ịba ọcha n'anya nke aldosterone, ọbara ọgbụgba, mgbali n'ọgba akwara, na-ebelata ibu ọrụ, nwere mmetụta diuretic. Ọ na-egbochi mmepe nke hypertrophy myocardial, na-eme ka nnabata mmega ahụ nwee ndị ọrịa nwere nkụda mmụọ obi na-adịghị ala ala.

Mgbe otu mkpụrụedemede ọnụ gasịrị, mmetụta hypotensive (systolic na diastolic ọbara na-ebelata) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24. Mmetụta hypotensive kachasị na-etolite izu 3-6 mgbe nchịkwa ọgwụ mgbe niile.

Ọ naghị egbochi ACE na, yabụ, anaghị egbochi mbibi bradykinin, yabụ, losartan enweghị mmetụta ndị ọzọ na-akpaghị aka na bradykinin (dịka ọmụmaatụ, angioedema).

N'ime ndị ọrịa nwere ọbara mgbali elu na - enweghị conellitus diabetes mellitus nwere proteinuria (karịa 2 g / ụbọchị), iji ọgwụ ahụ belata proteinuria, oke nke albumin na immunoglobulins G.

Na-eme ka ọkwa urea dị na plasma ọbara. Ọ naghị emetụta mgbanwe mgbanwe nke ahịhịa, ọ naghị enwe mmetụta na-adịgide adịgide na ọkwa nke norepinephrine na plasma ọbara.

N'ihe ruru 150 mg, 1 oge / ụbọchị anaghị emetụta ọkwa nke triglycerides, cholesterol na HDL kọlesterol (HD) n'ọbara ọbara na ndị ọrịa nwere ọbara mgbali elu. N'otu usoro, losartan anaghị emetụta glucose ọbara na-ebu ọnụ.

Mgbe a na - ahazi ya, losartan na - etinye obi gị dum na ngọngọ nri. Ọ na - eme metabolism n'oge “ụzọ mbụ” site na umeji site na nnyefe ya na ntinye nke CYP2C9 isoenzyme na nguzobe metabolite na - arụ ọrụ. Adị bioav adị nke losartan dị ihe dịka 33%. C max nke losartan na metabolite na-arụ ọrụ na-enweta n'ọbara ọbara ka ọ dị ihe dị ka elekere 1 na awa 3-4 mgbe ịbanyesịrị, n'otu n'otu. Iri nri anaghị emetụta ndu okike nke losartan.

Mgbe ị na-a theụ ọgwụ ahụ n’ọnụ na onunu ruo ihe dị ka 200 mg, losartan na metabolite na-arụ ọrụ ya bụ ihe ndị e ji mara lineacokinetics.

Ngwakọta nke losartan na metabolite ya na-arụ ọrụ na protein plasma (ọkachasị na albumin) karịrị 99%. V d losartan - 34 l. Losartan adịghị abanye na BBB.

Odika 14% nke losartan a na-eji ma ọ bụ ọnụ na-agwa onye ọrịa ka agbanwere metabolite na-arụ ọrụ.

Mkpochapụ plasma nke losartan bụ 600 ml / min, metabolite na-arụ ọrụ bụ 50 ml / min. Nwepu nke losartan na metabolite ya na-arụ ọrụ bụ 74 ml / min, yana 26 ml / min, n'otu n'otu. Mgbe ingesred, ihe dị ka 4% nke ọgwụ a na-ewepụ ya bụ akụrụ na-agbanweghi agbanwe ihe dịka 6% na-apụkwa na akụrụ n'ụdị metabolite na-arụ ọrụ. Mgbe nchịkwa ọnụ gasịrị, plasma ahụ nke losartan na metabolite na-arụ ọrụ ya na-agbada nke ukwuu na njedebe T 1/2 nke losartan ihe dị ka awa 2, yana metabolite na-arụ ọrụ bụ ihe dị ka awa 6-9. Mgbe ị na-a theụ ọgwụ ahụ na ọgwụ nke 100 mg / ụbọchị, ma losartan ma ọ bụ metabolite na-arụ ọrụ bụ nke ukwuu budata. cumulite na plasma ọbara.

A na-ahụ Losartan na metabolites ya na eriri afọ na akụrụ.

Pharmacokinetics n'ihe gbasara ọrịa

N'ime ndị ọrịa nwere nsogbu ịrụbiga mmanya na-egbu egbu ruo obere ruo n'ọtụtụ, losartan bụ oge 5, metabolite na-arụ ọrụ ji okpukpu 1.7 karịa nke ndị ọrụ afọ ofufo nwere ahụ ike.

Site na CC ihe karịrị 10 ml / min, itinye uche nke losartan na plasma ọbara adịghị iche na nke ahụ na-arụ ọrụ na-arụ ọrụ na nkịtị.N'ime ndị ọrịa chọrọ ọgwụgwọ maka ịba oke, uru nke AUC dị ihe dị ka ugboro abụọ karịa ndị ọrịa nwere ọrụ mkpo nkịtị.

A naghị ewepụ losartan ma ọ bụ metabolite na-arụ ọrụ na ahụ site na mmegharị ahụ.

Ọkpụkpọ nke losartan na metabolites na-arụ ọrụ na plasma ọbara n'ime ụmụ nwoke meworo agadi na-arịa ọbara mgbali elu adịghị iche na ụkpụrụ nke paramita ndị a na ụmụ okorobịa na-arịa ọbara mgbali elu.

Ofkpụrụ nke uru plasma nke losartan n'ime ụmụ nwanyị nwere ọbara mgbali elu bụ ugboro abụọ karịa ọnụahịa ndị kwekọrọ na ụmụ nwoke na-arịa ọbara mgbali elu. Ntinye uche nke metabolite na-arụ ọrụ n’ime ụmụ nwoke na ụmụ nwanyị adịghị iche. Ọdịiche ụlọ ọgwụ a enweghị ihe gbasara ọgwụgwọ.

- nkụda obi na-adịghị ala ala (ya na ọghọm ọgwụgwọ nke ndị na - egbochi ACE),

- nephropathy na ụdị ọrịa shuga mellitus 2 (belata ihe ize ndụ nke ịmalite hypercreatininemia na proteinuria),

- belata ihe ọghọm nke ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na mgbali ventricular hypertrophy.

- lactation (inye ara),

- gbara afọ 18 (agbadobeghị ịdị irè na nchekwa),

- lactose anagide, galactosemia ma ọ bụ glucose / galactose malabsorption syndrome,

- Hypersensitivity na mmiri nke ọgwụ.

Na akpachapụ anya, ekwesịrị iji ọgwụ ahụ mee ihe maka ọrịa ịba ọcha n'anya na / ma ọ bụ akụrụ, mbelata nke bcc, mmerụ mmiri-electrolyte emetụtara, obere akwara akwara stenosis ma ọ bụ stenosis nke otu akụrụ akwara.

Edere ọgwụ a ọnụ 1 / ụbọchị, n'agbanyeghị nri.

Site n'ọbara mgbali elu n'ọtụtụ oge, usoro izizi na mmezi bụ 50 mg 1 oge / ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba nke ọgwụ a ka ọ bụrụ 100 mg / ụbọchị na 1 ma ọ bụ 2 doses.

Na-emegide ihe ndabere nke ị diụ ọgwụ na ọgwụ dị elu, a na-atụ aro ịmalite ọgwụgwọ na ọgwụ Lozarel na 25 mg (1/2 tab. 50 mg) 1 oge / ụbọchị.

Na nkụda obi na-adịghị ala ala, ọgwụ mbụ bụ 12.5 mg / ụbọchị, nke na-esote kwa izu ugboro abụọ nke ugboro abụọ rue 50 mg / ụbọchị, dabere na ịnagide ọgwụ ahụ. Mgbe ejiri ya na ọgwụ mbụ nke 12.5 mg, a na-atụ aro iji ụdị usoro onunu ogwu nwere obere ọdịnaya nke ihe na-arụ ọrụ (mbadamba 25 mg n'ihe ize ndụ).

Na ụdị ọrịa shuga mellitus 2 nke nwere proteinuria (na -ebelata ihe ize ndụ nke ịmalite hypercreatininemia na proteinuria), oge mbụ bụ 50 mg 1 oge / ụbọchị na 1 dose. N'oge ọgwụgwọ, dabere na ọbara mgbali ọbara, ị nwere ike ịbawanye ọgwụ kwa ụbọchị nke ọgwụ ahụ ka 100 mg na 1 ma ọ bụ 2 doses.

Mgbe ị na-eji ọgwụ Lozarel eme ihe iji belata ihe ize ndụ nke nsogbu ọrịa obi na onwu n'ime ndị ọrịa nwere ọbara mgbali elu na ogwe aka ekpe ventricular, ọgwụ mbụ bụ 50 mg 1 oge / ụbọchị, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ ahụ na 100 mg / ụbọchị.

Ndị ọrịa nwere nsogbu akụrụngwa ezighi ezi (CC erughi 20 ml / min), nke nwere akụkọ banyere ọrịa imeju, akpịrị ịkpọ nkụ, n'oge usoro ịba ahụ, yana ndị ọrịa karịa afọ 75, a na-atụ aro ka ọ depụta ọgwụ ahụ na obere mbido mbụ - 25 mg (1/2 tab. 50 mg) 1 oge / ụbọchị.

Ọtụtụ mgbe, nsonaazụ ya dị nro ma dịkwa obere, anaghị achọ ịkwụsị ọgwụgwọ.

Ime na lactation

Edere Lozarel Plus n'oge ime afọ / n'idochi ya.

Mgbe ị theụ ọgwụ ọjọọ n’ime oge II - III nke afọ ime, mmebi nke nwa ebu n’afọ na-etolite, enwere ike, ọgwụgwọ nwere ike ibute ọnwụ ya. Ihe ọghọm nke nsogbu ndị na-esote na nwa ebu n’afọ na-abawanye: nwa ebu n'afọ na jaundice nke nwa amụrụ ọhụrụ. Nne nwere ike ịmalite thrombocytopenia. Ekwesịrị ịkagbu Lozarel Plus ozugbo nkwenye nke afọ ime.

Mgbe ị na-atụle uru na ọghọm dị na iji Lozarel Plus, ụmụ nwanyị na-azụ nwa kwesịrị iburu n'uche na thiazides dị na mmiri ara, na amụbeghị profaịlụ nchekwa nke losartan. Ọ bụrụ na ọ dị mkpa iji Lozarel Plus, inye nwa ara kwesịrị ịkwụsị.

Na arụ ọrụ ezumike ọrụ

N'ime ndị ọrịa nwere nnukwu akụrụ akwara (CC na-erughị 30 ml / min), ọgwụ ọgwụ na-egbochi ọgwụ.

Site na mmezi akụrụngwa na-agafeghị oke (CC 30-50 ml / min), ejiri nlezianya debe Lozarel Plus.

Dọzigharị usoro ọgwụgwọ mbụ nye ndị ọrịa nwere obere akwara afọ, gụnyere ndị nke na diaalysis, anaghị achọrọ.

Na arụ ọrụ imeju

Maka ndị ọrịa nwere nnukwu ịba ọcha n'anya (dị ka ọnụ ọgụgụ ụmụaka-Pugh nke ihe karịrị isi 9), a na-egbochi ọgwụ ndị a na-ejikọ ọnụ na antihypertensive.

Site na ọrịa imeju na-aga n'ihu na ọrụ ịba ọcha n'anya na-erughị isi 9 na ọnụ ọgụgụ nke Child-Pugh Lozarel Plus, a na-eji ya n'okpuru nlekọta ahụike.

Ngwakọta na ụdị ntọhapụ

A na-ere ọgwụ ahụ n'ụdị biconvex, mbadamba okirikiri, nke mkpuchi dị ọcha na-acha odo odo. Ọ bụrụ na inyinya mbadamba ahụ ụzọ abụọ, n'ime ya ị nwere ike ịchọta isi ọcha ma ọ bụ nke na-acha ọcha. Mpempe 30 ọ bụla nwere mbadamba iri atọ.

Dị ka ihe mejupụtara, ọgwụ nwere ike ịnwe 12.5 mg nke hydrochlorothiazide na 50 mg nke potassium losartan ma ọ bụ 25 mg nke hydrochlorothiazide na 100 mg nke potassium losartan.

Isi nke Lozarel Plus nwere lactose monohydrate, stachi pregelatinized, MCC, colloidal silicon dioxide, magnesium stearate.

Ihe mejupụtara shei ahụ bụ iron ironide oxide (nsị), hyprolose, titanium dioxide, hypromellose.

Lozarel: ntuziaka maka ojiji, ọnụahịa, analogues

Lozarel bụ ọgwụ na-ebelata ọbara mgbali elu nke ejiri n'ọtụtụ ebe na-agwọ ndị nwere ọbara mgbali elu, obi na ọrịa shuga (iji chebe akụrụ). Dịka ọgwụ ọ bụla, o nwere ụfọdụ ihe egosi, contraindications na nsonaazụ ya.

Ọnọdụ, oge nchekwa

Chekwaa Lozarel Plus na ogo okpomoku di elu +25 na erughi afo abuo.

Nye ndị bi na Russia na-eburu ọgwụ na-akwụ 200-300 rubles.

Atụmatụ ọnụahịa Lozarel Plus na Ukraine - 240 hryvnia.

Analogues nke ọgwụ bụ ọgwụ dịka Lozartan N, Simartan-N, Lozartan-N Canon, Presartan N, Lorista ND, Lorista N.

Na-ekpe ikpe site na nyocha, Lozarel Plus na-ebelata ọbara mgbali n'ụzọ dị irè ma na-emetụta ọnọdụ nke usoro obi obi nke ọma.

Ndị dọkịta kwuru na ọgwụ a adabaghị maka ndị ọrịa niile nwere ọbara mgbali elu, yabụ ịkwesịrị ị were ya na nkwanye dọkịta.

Nwere ike gụọ nyocha nke ndị ezigbo mmadụ hapụrụ.

Ntụziaka maka ojiji

N'ikwekọ na ntuziaka maka ojiji a na-a drugụ ọgwụ ahụ otu ugboro n'ụbọchị. Ha na-eme ya abụọ n’afọ na-enweghị isi, na mgbe ha risịrị nri.

Na usoro ọgwụgwọ ọbara ọgbụgba, ihe mbụ na-esote ya bụ 50 mg otu ugboro n'ụbọchị. Site na nsonaazụ ezughi oke, a na-abawanye usoro onunu ogwu ka 100 mg kwa ụbọchị (ọ bụrụ na achọrọ, enwere ike ekewa abụọ).

Na usoro ọgwụgwọ nke nkụda obi na-adịghị ala ala, usoro ọgwụgwọ mbụ bụ 12.5 mg (otu ụzọ n'ụzọ anọ nke mbadamba) kwa ụbọchị, na-esote mmụba (usoro ahụ na-amụba okpukpu abụọ kwa izu). Ekwesịrị ịgaghị karịa 50 mg kwa ụbọchị.

Iji belata ihe ize ndụ nke ịmalite hypercreatininemia na proteinuria na ndị ọrịa nwere ụdị ọrịa shuga nke 2, ịgwọ ya na ọgwụ ahụ na-amalite site na 50 mg otu ugboro n'ụbọchị. Nke a mere, a na-abawanye kwa ụbọchị kwa ụbọchị (yana ezigbo mmetụta na-anaghị arụ ọrụ nke ọma) ruo mg mg 100 nke ewere n'otu otu ma ọ bụ abụọ.

Iji belata ihe egwu na ọrịa obi na ọnwụ n’etiti ndị nwere ọbara mgbali elu yana oke mgbidi ventricular aka ekpe, a na-amalite ọgwụ na 50 mg otu ugboro n’ụbọchị. Ọ bụrụ na ọ dị mkpa, mee ka ọgwụ ahụ gaa na 100 mg kwa ụbọchị.

A na-atụ aro iji obere usoro onunu (25 mg kwa ụbọchị) maka ndị mmadụ:

ihe karịrị afọ 75
arịa ọrịa akpịrị ịkpọ nkụ, ọrịa imeju na akụrụ,
ịdị na-arịa ọrịa.

Nyocha na Lozarel

Afọ ise gara aga, enwere m obi nkụchi. Agbalịrị m ihe niile ACE inhibitors, mana ọ fọrọ nke nta ahụghị mgbanwe ọ bụla dị mma. Ekem dọkta ama ọnọ mi Lozarel. Ka a na-ewere ọgwụgwọ ahụ, ọ malitere ịchọpụta na ike gwụrụ ya, mgbe ahụ ọzịza n'ụkwụ ya na ogwe aka belatara, mgbe ahụ mkpụmkpụ ume na-apụ n'anya. Ọgwụ a anaghị eme ihe ozugbo, mana oge ị takeụrụ ya, ọ ga-achọpụta nke ọma na nsonaazụ ya ga-apụta. Mgbe ọnwa ise gasịrị, ewepụsịrị m ụkwara abalị na-agwụ ike, ma ugbu a enwere m ike ịnya isi n'ihi enweghị adịghị ike na ọzịza. Ee, na iku ume ọkụ adịghị apụta ”