Ntụziaka maka ojiji insulin Rosinsulin P, M, C

Rosinsulin bụ ụdị ụdị mmiri homonụ nke enwere ike imepụta na ụdị atọ atọ, ya bụ: C, P, na M. N'ikwu okwu banyere nke ọ bụla, ọ dị mkpa ị attentiona ntị n'eziokwu ahụ bụ na C bụ insulin nke oge ọrụ, P, na ntụle, dị mkpụmkpụ, na M bụ mgbanwe ngwakọta (agwakọta insulin 30% soulin na insulin 70%). A na-atụ aro ya nke ọma ka ị mata atụmatụ nke ụdị nke ọ bụla dị na akụkụ homonụ nke ọkọnọ.

Ihe ịchọrọ ịma gbasara Rosinsulin R?

Rosinsulin P ka egosiri maka iji ụdị 1 na ụdị ọrịa shuga mellitus 2 mee ihe. N'ọnọdụ nke abụọ, anyị na-ekwu maka usoro nke obere ikike ịba ụba nke hypoglycemic ogige. Na mgbakwunye, a na-atụ aro ka eji rụọ ọrụ na ketoacidosis na-arịa ọrịa shuga, ọrịa shuga nke mere n'oge afọ ime, yana nsogbu metabolic. Ihe omuma ndi ozo na-eduga n'iji ogwu dika Rosinsulin P nwere ike idi nkpa, ya mere o dikwa nma ka icho onye dibia endocrinologist banyere ya.

Emepụtara homonụ a n'ụdị edozi pụrụ iche maka ịgba ntụtụ, ogo ogo mmadụ na-elekwa ahụ anya zuru oke na hypoglycemia kwesịrị ịtụle contraindications maka iji ya. N'ịchọpụta njirimara nke iji ụdị ngwaọrụ a dị ka Rosinsulin P, a na-atụkarị aro ị paya ntị n'eziokwu ahụ:

a na-achịkwa ihe mejupụtara ya na subcutaneously, intramuscularly na intravenously,
Ekwesịrị ime nke a ihe dị ka ọkara otu awa tupu eri nri,
a kwesiri ịtụle usoro kachasị eji ngwa ahụ dị ka subcutaneous, ebe ya na ketoacidosis ma ọ bụ ọrịa shuga, yana usoro ntinye aka na ntanetị, ma ọ bụ intramuscularly,
mgbe ị na - enye monotherapy, ọnụ ọgụgụ ndị nlekọta ga - abụ ugboro atọ n'ụbọchị (ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọnụ ọgụgụ a),
mpaghara injection nke Rosinsulin R na-agbanwe oge ọ bụla iji zere ịkpụzi lipodystrophy (anyị na-ekwu maka mgbanwe na nhazi nke subcutaneous ma ọ bụ abụba anụ ahụ),
nkezi nke ụbọchị ga-abụ site na 30 ruo 40 nkeji na okenye, mgbe na nwa - 8 nkeji.

Njikọ ga - ekwe omume na ngwakọta homonụ nke nwere ihe ngosi ogologo oge. Ọ ga-adị mkpa ịnweta mkpokọta insulin site na vial ahụ, na-ejide n'aka na a kụrụ ya na ntụtụ ahụ sirinji. Mgbe agwesịrị iruu subcutaneous, a na-ahụpụta nsonaazụ ahụ n'ime nkeji 20-30. The erute kacha ga-amalite n’ihe dị ka awa abụọ. Ọ bụ ezie na nsonaazụ ahụ ga-aga n'ihu, ọ dabere na usoro a kapịrị ọnụ, ọ dịkarịa ala awa ise. Ogologo oge ekpughere akụkụ nke homonụ ga-adabere na usoro onodu ogwu, usoro, mpaghara nchịkwa ma nwee njiri mara mmadụ.

Ọ ga-amasị m ịdọrọ uche gaa n'eziokwu ahụ bụ na iji Rosinsulin P, ị nwere ike ịhụ mmepe nke hypoglycemia. Ndị ọrịa nwere ọrịa shuga nwere ike ịnagide obere hypoglycemia nke ha hụrụ site na iji shuga ma ọ bụ ngwaahịa nwere oke carbohydrates. A na-atụ aro hypoglycemia nke gara aga ka a kọọrọ ndị dibịa bekee iji wee dozie okwu banyere mkpa ọ dị maka idozi ọgwụgwọ.

Ihe kacha mkpa banyere Rosinsulin M

Versiondị ọzọ nke insulin a gosipụtara bụ ụdị Rosinsulin M. Dị ka anyị kwurula, anyị na-ekwu maka akụkụ homonụ nke oge ogo ikpughe. Ọ bụ ihe kwesịrị ịrịba ama na oge mkpughe ga-adabere n’ihe dị iche iche - ọbụghị naanị n ’iwere mkpokọta, kamakwa na usoro onodu ogwu, usoro ya na mpaghara mmejuputa ya. Rosinsulin M na-amalite ime ihe dị ka nkeji iri atọ mgbe ọ gbasịrị ọgwụ subcutaneous. Mmetụta kachasị ga-etolite n'etiti oge ahụ site na awa anọ ruo awa iri na abụọ, ebe oge ọrụ ga-akarịghị awa iri abụọ na anọ.

N'ikwu banyere ngosipụta, ọ dị mkpa ị attentiona ntị na ụdị 1 na ụdị ọrịa shuga mellitus 2. N'okwu nke abụọ, a na-eji ngwá ọrụ ahụ, ọkachasị, nwere mgbochi iji aha hypoglycemic nke aha. Ọzọkwa, ọ ga-adị mkpa iji Rosinsulin M mee ihe na njikọta ọgwụ na ọnọdụ a na-akpọ intercurrent (na mberede ijikọ ọrịa na ọrịa ndị dị adị).

Dị ka anyị kwuru na mbụ, Rosinsulin M bu n'obi maka nchịkwa subcutaneous. Ọ na-ike na-atụ aro na:

onunu ogwu nke mpaghara homonụ a kpebiri site n’aka onye ọrịa diabetologist n’otu n’otu n’otu. Ntọala na-eduga, n'ezie, bụ rashọnọ ọbara ọbara,
na nkezi, ụdị ọgwụ a n'oge ụbọchị ga - adị site na 0,5 ruo 1 IU / n'arọ ahụ,
ihe ndị na - egosi ọnọdụ insulin na - eji insulin eme ihe kwesịrị ikwekọ na okpomoku ụlọ,
tupu iji, nkwanye ahụ na-akpachapụ anya na akwa oke ruo mgbe edo edo.

Rosinsulin M n'ọtụtụ ikpe ka egosiri nke ọma na akụkụ nke anụ ahụ. A pụkwara ịme inje n'ihu ihu mgbidi nwa, ma ọ bụ, dịka ọmụmaatụ, n'ubu (na amụma nke ihe akpọrọ deltoid muscle). Ọ na-akwadoro ka ịgbanwee ebe ntụtụ ahụ n'otu mpaghara anatomical, n'ihi na nke a bụ ihe ga-eme ka o kwe omume ịghara ịbịakwute lipodystrophy. Ọnọdụ ọrịa a na-efe efe, ọkachasị ọrịa na ọrịa na-esonụ n'ọkụ, ga-amụbawanye mkpa maka iji ihe nnọchianya a dị ka Rosinsulin M.

Njirimara nke Rosinsulin C

Enwere ike iji ụdị hypoglycemic a maka ụdị 1 na ụdị ọrịa shuga mellitus 2. N'okwu a, enwere ike ịtụle ihe dị iche iche na-egosi, dịka ọmụmaatụ, ịtụrụ ime, ihe ịwa ahụ na ọbụna jikọtara ọnọdụ ọrịa. Rosinsulin C bụ ọgwụ achọrọ naanị maka nchịkwa subcutaneous.

N'ịchọpụta njirimara nke ngwa ahụ, ekwesịrị iburu n'uche na site na nchịkwa subcutaneous, ekwesịrị ịme ihe a karịa otu ugboro ugboro abụọ n'ụbọchị. N'okwu a, oge ga-adị ka nke a, ya bụ, nkeji iri atọ ruo iri anọ na ise tupu iri nri. A na-atụ aro ịgbanye ebe a na-agba ntụtụ oge ọ bụla. N'ọnọdụ ndị pụrụ iche, dibịa na-aga ga-edenye ọgwụ mgbochi ọ bụla n'ime akwara.

Ekwesịrị icheta na a na-amachibido nchịkwa insulin na oge ọrụ ogologo oge.

Ọzọkwa, na-ekwu okwu banyere Rosinsulin C na ntuziaka maka ojiji, payaa ntị na atụmatụ ndị dị ka usoro ahụ:

ekwesịrị ịhọrọ usoro onyonyo n'otu n'otu ma dabere na mkpokọta glucose ọ bụghị naanị n'ọbara, kamakwa mmamịrị, yana njiri mara nke ọrịa ahụ,
n'ọtụtụ ebe, dos si asatọ ruo 24 IU otu ugboro n'ụbọchị,
A ga-ebufefefe site na ụdị insulin gaa n'ụdị ụdị ọzọ nke hormonal n'okpuru nlekọta ahụike mgbe niile.

O yikarịrị ka mmetụta ụfọdụ ọ ga - etolite, dịka ọmụmaatụ, mmeghachi omume nfụkasị ahụ dịka urticaria ma ọ bụ ọbụna ahụ ọkụ na ujo. Onye na-arịa ọrịa mamịrị nwekwara ike ịmalite nchekasị, oke iwe, isi ọwụwa na mgbaàmà ndị ọzọ na-adịghị mma. Na mbido ọgwụgwọ dị otú ahụ, edema na nsogbu dị iche iche metụtara mgbagha na-etolite. Anyị na-ekwu maka nsogbu ọhụụ, nke na-adị nwa oge ma na-agafe ọsọsọ.

Iji ghọta nke ọma na ojiji Rosinsulin C, m ga-achọ ịma ihe ndị dị na usoro a dịka eziokwu ahụ bụ na a ghaghị idozi usoro ọgwụ maka ọnọdụ nke mmepe nke ọrịa na-efe efe. Ọ dịkwa nnukwu mkpa iji mebie ọrịa glandia endocrine, ọrịa Addison na ụfọdụ akụkụ ahụ ndị ọzọ, dịka ọmụmaatụ, site na afọ 65.

Ihe kpatara hypoglycemia na usoro iji Rosinsulin C na-abụkarị ikpe dịka ịdoụbiga mmanya ókè, dochie otu akụkụ hormonal ọzọ. Anyị ekwesịghị ichefu na otu n'ime ihe ndị na - akpata ihe na - akpata ya nwere ike ịbụ na - ahapụ isi nri, ọgbụgbọ, afọ ọsịsa, na ihe ndị ọzọ. A na-atụ aro ihe niile siri ike iburu n'uche ka ojiji a na-eji ụdị Rosinsulin niile arụ ọrụ nke ọma.

Ntuziaka maka onye ọrịa

Usoro ogwu maka insulin na vials

(ejiri ya na karama 5 na 10 ml kpuchie ya.)

Ọ bụrụ na onye ọrịa ahụ na-eji naanị otu ụdị insulin:

1. Na-egbochi ọnya rọba nke vial ahụ.

2. Wụsa ikuku n'ime sirinji na ọnụego ya na insulin chọrọ chọrọ. Tinye ikuku n'ime vial insulin.

3. Tụgharịa vial ya na sirinji kpodoro isi ala ma dọrọ ọgwụ insulin chọrọ ka ọ banye n'ime sirinji. Wepu agịga na vial ma wepu ikuku site na sirinji. Lelee ma ọ bụrụ na ọgwụ insulin dị ziri ezi.

4. Gbanye ozugbo.

Ọ bụrụ na onye ọrịa chọrọ ịgwakọta ụdị insulin abụọ:

1. Nwere ọnya roba na vials.

2. Ozugbo ozị ịpịgharị, tụgharịa karama insulin na-arụ ọrụ ogologo oge ('igwe ojii') n'etiti ọbụ aka gị ruo mgbe insulin na-acha ọcha ma nwee urukpuru.

3. Wunye ikuku n'ime sirinji na ọnụego kwekọrọ na insulin insulin nke urukpuru. Mee ka ikuku banye n’ime vial insulin nke igwe ojii wee wepu agịga na vial ahụ.

4. Dọrọ ikuku banye ntụtụ n'ime ọnụọgụ insulin na-adị mkpụmkpụ (“na-ahụ ụzọ”). Mee ikuku n'ime karama insulin doro anya. Tụgharịa karama ahụ jiri sirinji kpoo ma kpọnyere ọgwụ chọrọ ka insulin “doo anya” dị ọcha. Wepụ agịga ma wepụ ikuku si sirinji. Lelee dose ziri ezi.

5. Tinye insulin ahụ “urukpuru” wee banye agịga ahụ n'ime oghere ahụ, jiri sirinji kpuchie okpo ma kpoo insulin chọrọ. Wepu ikuku si na sirinji ma lelee ma ogwu a ziri ezi. Gbanye ngwakọta insulin anakọtara ozugbo.

6. Tinye insulin mgbe niile n'otu usoro dị ka akọwara n’elu.

Usoro eji eme ihe Cartridge

(agbakọtara na ngwugwu nwere ngwongwo milimita 3)

Cartridge nwere ọgwụ Rosinsulin R bu n'obi iji Penpen Classic 1-Unit, Autopen Classic 2-Unit syringe rụrụ, nke Owen Mumford Ltd., United Kingdom ma ọ bụ ya na ROSINSULIN ComfortPen reusable syringe pen nke arụpụtara Osisi Medsintez, Russia.

E kwesịrị ịdọ onye ọrịa ọdụ banyere mkpa ọ dị ịgbasochi ntuziaka na ntuziaka maka iji mkpụrụ akwụkwọ sirinji maka inye insulin.

Tupu ojiji, gbaa mbọ hụ na enweghị mmebi (dịka ọmụmaatụ, cracks) na katriiki ya na Rosinsulin P. Ejila katriiki ma ọ bụrụ na enwere mmebi ọhụhụ ọ bụla. Mgbe etinyere katriati n’ime mkpịsị sirinji, ị ga-ahụrịrị ibe ọcha na windo nke ihe eji klọọkụ.

Mgbe a gbasịrị ya, agịga kwesịrị ịdị n’okpuru anụ ahụ ma ọ dịkarịa ala 6 sekọnd. Debe bọtịnụ ahụ ruo mgbe a kpochapụrụ agịga ahụ n'okpuru akpụkpọ ahụ, wee si otú a hụ na usoro nchịkwa kwesịrị ekwesị na ohere nke ọbara ma ọ bụ lymph ịbanye na agịga ma ọ bụ klọọkụ insulin.

A na-echere katọn ahụ nwere Rosinsulin P maka naanị otu onye, ọ gaghị emegharị.

Site na iji mkpịsị aka abụọ, were akpụkpọ ahụ, gbanye agịga ahụ n'okpuru isi mkpanaka ahụ n'akụkụ ihe dị ka 45 Celsius ma gbanye insulin n'okpuru anụahụ. Mgbe ịgba ntụtụ ahụ, agịga kwesịrị ịdị n’okpuru anụ ahụ ma ọ dịkarịa ala 6 sekọnd iji hụ na etinye insulin ahụ kpamkpam. Ọ bụrụ na ọbara apụta na ebe a gbanye ọgwụ were agịga, were nwayọ pịa ebe a na-agba nkwụ ya na mmiri. Ọ dị mkpa ịgbanwe saịtị ịgba ntụtụ.

Ntuziaka maka iji mkpụrụ edemede eji emeghe agbaji tupu-emeghe Autopen Classic 1-Unit

Autopen Classic Syringe Pen bụ mkpụrụ dị mfe ịchọrọ ị singleụ ọgwụ eji eme ihe maka ọtụtụ injections, ezubere maka nchịkwa insulin Rosinsulin nwere ọrụ nke 100 IU / ml na katrized 3.0 ml. Kwekọrọ na agịga ọ bụla nke mkpụrụ sirinji. Biko lee ntuziaka ndị a ga -ekwu maka iji sirinji pensụ.

Ọ bụrụ na emeghị ihe a gwara gị mee, o nwere ike ime ka ịulinụ ọgwụ insulin zuru ezu.

Ihe mejupụtara mkpịsị ọdee akwụkwọ edere nkwụchi eji

3. Mwepụta tọhapụ

4. Dose Selector

6. Ihe njide Cartridge

8. Hapụ nkwụnye bọtịnụ

9. Dose Selector Ada

Nkwadebe maka ojiji

Kpoo okpu nke mkpịsị mkpụrụ ọgwụ eji debeepu tupu iwepu ya. Ewepula akara sitere na pen sirinji edebere ede.

Wepu ihe nkpuchi na agịga ọhụrụ (agịga agunyeghị). Ghaa agịga ahụ ozugbo na ihe nkwakọ ngwaahịa ahụ. Wepu okpu nchebe na mpụta agịga.

Soro usoro 2-3 tupu ntụtụ ọ bụla. Ọ dị mkpa ịkwadebe mkpịsị ọ bụla eji agbaji agbaji maka iji wepu ikuku niile nwere ike ịnọ na agịga ahụ. Tupu ịmalite, tọọ nkeji 8 na onye na-ahọrọ ọgwụ (Fig 2A / 2B).

Jide mkpịsị ọdeejị eji emeju tupu ị ga-eji ya. Pịa ma jide akara mmalite ruo mgbe akara ngosi Àkụ ahụ nke mkpụrụ sirinji na-alaghachi akara ahịrị na nhọpụta nke ọnụọgụ.

Kpoo ma belata otu nkeji abụọ otu otu rue mgbe ntanye insulin pụtara na njedebe nke agịga (Fig 3A / 3B). Ugbu a, mkpịsị mkpụrụ eji sirinji dechara dị njikere maka ojiji.

Ọ bụrụ na, mgbe ị na-eme usoro nke atọ, onye na-ahọpụta ọgwụ alaghachuteghị n'ọnọdụ akara amalite ma insulin apụtaghị n'ọnụ ọnụ agịga ahụ, ọ ga - ekwe omume na agịga ejiri mkpịsị eji sirinji dejupụta ihe dịbu. N'okwu a, wepu agịga ochie wee jiri nke ọhụrụ dochie ya. Kwugharị usoro 2-3.

Gbaa mbọ hụ na akụ ahụ the n’elu ahụ nke mkpịsị mkpụrụ ọgwụ agbajurujuru dọrọ ga-egosi akara mmalite nke onye ahọpụtara. Kpọọ nọmba nke chọrọ. Emegharịgharịla ihe ndị na-ahọrọ ihe na mpaghara ndị ọzọ, nke nwere ike ibute mmebi nke mkpụrụ sirinji dejuru ihe eji mejupụtara ya, n'ihi nke a, ka etinyeghị usoro a na-ezighi ezi.

Ọ bụrụ n’ị kwụrụ ihe karịrị ọgwụ insulin chọrọ, anyị na-akwado gị ka iwepu ọgwụ na-ezighi ezi wee jupụta ego ole achọrọ.

Tupu ntụtụ, gbaa mbọ hụ na aro a gosipụtara ọnụọgụ nkeji dị na nhọrọ ọnụọgụ. Dịka ọmụmaatụ, figures 4A na 4B na-egosi ọnọdụ ziri ezi maka ịlekọta 20 insulin insulin.

Tinye ọgwụ ntụtụ site na iji ọgwụ ịgba ọgwụ nke dọkịta gị gwara gị.

Pịa bọtịnụ mkpopụta na-agbanye agịga ma jide ruo mgbe mmalite ahịrị na nhọpụta ọnụọgụ ga-alaghachi na njiri akụ ► n'ahụ ahụ nke sirinji enwere ike iwere. Guo 10 ma wepụta agịga na akpụkpọ gị.

Ọ bụrụ n ’ịhọrọ ọgwụ were were kwụsị tupu akara amalite ịgbakwute akụ a, ọ pụtara na inwetabeghi ọgwụ insulin chọrọ. Ahọpụta na-ahọpụtara na-egosi nọmba nke ngalaba a ga-eme maka insulin zuru ezu.

Kwupu isi agịga dị na mpụga ma yọpụ agịga site na sirinji eji emeju. Lelee mgbe niile na ajịpụrụ agịga ahụ.Debe okpu nke mkpịsị mkpụrụ ogwu eji emeghe nke ọma (Fig 6). Mwepu nke agịga eji eme ihe dị ka nkwenye ndị ọrụ ahụike na ụkpụrụ ịdị ọcha na nke ọrịa.

Ekwesịrị iji mkpụrụ mkpịsị ọrịị eji emeju tupu ị gwaa onye na-ahụ maka ahụike gị.

Before Tupu ntụtụ ọ bụla, gbaa mbọ hụ na mkpịsị ọdee eji etinyere ya ụdị ọgwụ insulin ọ bụla nke ndị ọrụ nlekọta ahụike depụtara ya.

Gụọ ma soro ntuziaka maka ojiji insulin na-aga ọgwụ. Gbaa mbọ hụ na a kwadebere mkpụrụ mkpịsị mkpụrụ eji agbaji eji eme ihe na ntuziaka na paragraf 2-3.

Imebi usoro a ga - eji dozie mkpịsị ọrịre eji dejuru ihe eji eme ihe ga - eduga n ’iwebata insulin nke ezughị oke.

For Maka ọgwụ mgbochi ọ bụla, jiri agịga ọhụrụ. Ozugbo ogwu ogbugba ahụ, a ga-ewepụ ma ọ bụ kpochapụ agịga ahụ n'ụzọ adịghị mma. Ọ bụrụ na agịga dị na mkpịsị akwụkwọ a, nke a nwere ike ibute ịchiri ọnụ ma emetụta izi ezi nke dose ahụ.

If Ọ bụrụ n ’ipụpura mkpịsị mkpụrụ sitere na sirinji ị hụrụ ihi insulin, ị nwere ike itinyeghị insulin chọrọ kpamkpam. Anwala imejupụta insulin furu efu nke gbara ya nke abụọ (ị nwere ike ibute shuga ọbara gị nke ukwuu). Dịka ịkpachara anya, anyị na-adụ gị ọdụ ka ị na-enyocha shuga ọbara gị oge niile, gụọ ntuziaka maka ojiji insulin ọgwụ, ma ọ bụ kpọtụrụ ndị ọkachamara ahụike gị.

Kwee dọkịta gị ma ọ bụrụ na ị na-achọpụta ọ̀tụ̀tụ̀ shuga dị iche iche nke ọbara.

Nchekwa na mkpofu

Must A ga-echerịrị mkpụrụ sirinji eji eme ihe ọ bụla ka ejiri agịga mịrị na okpu kpuchie ya mgbe niile.

Agaghị enwe ike iji mkpụrụ edemede sirinji enwere ike ịnwere ma ọ bụrụ na ọ nọghị na friji karịa oge akọwapụtara na ntuziaka maka ojiji ahụike.

Pen Mkpụrụ edemede sirinji eji eme ihe nke ị na-eji ugbu a kwesịrị ịchekwa ya n'ụlọ okpomọkụ 15-25 Celsius C karịa ụbọchị iri abụọ na asatọ, na-echebe ya site na anwụ na-acha ozugbo.

With jiri akwa mmiri dee syringe. Ekwekwala pen nke ọma na mmiri.

Should A ga-echekwa mkpụrụ ndụ mịrị amị nke na-adịghị arụ ọrụ na friji n'oge okpomọkụ 2 ruo 8 Celsius.

8 Debe sirinji ndị enwere ike ịnara nke ọma tupu ụmụaka eruo.

Pose tufuo agịga ejiri na ntụaka aka ha, ma ọ bụ nke ndị ọrụ nlekọta ahụike tụrụ aro ya.

Kpofuo mkpịsị sirinji eji agịghị jikọtara ha na dịka dọkịta gị si kwu.

Anwalela mkpụrụ edemede sigpeneti Autopen Classic ma mezuo ihe achọrọ nke ISO 11608-1 maka izi ezi.

Agụnyere akwụkwọ ntuziaka a na ngwugwu nwere pensọm sirinji 3 ml nke enwere ike iji dochie ya.

Syringe pen emeputa: “Owen Mumford Ltd.”, UK.

Ntuziaka maka mkpịsị ọrịre dị mkpụkọ mkpụrụ tupu ROSINSULIN ComfortPen nke LLC Plant Medsintez rụpụtara.

Edere mkpụrụ akwụkwọ sirinji iji dozie insulin Rosinsulin nwere ọrụ nke 100 IU / ml na katrized milimita atọ. Kwekọrọ na agịga ọ bụla nke mkpụrụ sirinji.

Biko lee ntuziaka ndị a ga -ekwu maka iji sirinji pensụ.

Ọ bụrụ na emeghị ihe a gwara gị mee, o nwere ike ime ka ịulinụ ọgwụ insulin zuru ezu.

Ihe mejupụtara mkpịsị mkpụrụ eji agbajị mkpụrụ eji agbaji ROSINSULIN ComfortPen mepụtara site na Plant Medsintez LLC

1. Nkwadebe maka ojiji

A. Mepụta okpu nke mkpịsị mkpụrụ ọgwụ eji debechaa tupu iwepu ya. Ewepula akara sitere na pen sirinji edebere ede.

B. Wepu ihe nkiri na-echebe na agịga ọhụụ (agaghị agunye).

Fig. 2. Akụkụ nke agịga

Ghaa agịga ahụ ozugbo na ihe nkwakọ ngwaahịa ahụ.

Wepu mpụta, mgbe ahụ agịga dị n'ime. Ahapụkwala akwa mpụta.

B. Ọ dị mkpa ịkwadebe mkpịsị ọ bụla eji agbaji agbaji tupu iwere ihe izizi iji wepu ikuku niile nwere ike ịdị na ya.

Nịm 8 nkeji na dose Selector.

Jide mkpịsị ọdeejị eji emeju tupu ị ga-eji ya. Pịa bọtịnụ mkpochi ahụ wee nọgide na-pịa ya ruo mgbe akara efu dị na windo nhọrọ ọnụọgụ ga-adaba na pointer na ikpere sirinji. Ọ bụrụ na mgbe insulin a egosighi na njedebe agịga ahụ, soro usoro 1G.

D. Anakọta ma wedata nkeji abụọ otu otu rue mgbe insulin pụtara na njedebe nke agịga (Fig 5, 6).

Ugbu a, mkpịsị mkpụrụ eji sirinji dechara dị njikere maka ojiji.

Ọ bụrụ na onye na-ahọpụta ọgwụ alaghachighị akara efu ma insulin apụtaghị n'ọnụ ọnụ agịga ahụ, ọ ga - ekwe omume na agịga ejiri mkpụrụ mkpịsị eji sụfue edeju tupu enwere ya. N'okwu a, wepu agịga ochie wee jiri nke ọhụrụ dochie ya. Kwugharị nzọụkwụ 1G.

2. Ọchịchị nchịkwa

A. Gbaa mbọ hụ na ihe dị n’ahụ nke mkpụrụ mkpịsị mkpụrụ eji dejuru ma ga-atụ aka na akara odo na windo ahọpụtara nke onyonyo. Kpọọ nọmba nke chọrọ.

Zọ insulin na-ezighi ezi na ROSINSULIN Nkasi obi Pen pen syringe nke Zavod Medsintez LLC mepụtara nwere ike ịgbanwe ya site na ịgbagharị ọkpụkpọ ọkpụkpọ ọnụọgụ n'akụkụ ọ bụla.

Tupu ntụtụ, gbaa mbọ mata na akụkụ ahụ na-arụtụ aka ọnụ ọgụgụ chọrọ nke nkeji na mpịakọta ahọpụtara.

B. Tinye ntụtụ ntụtụ site na iji ọgwụ ịgba ọgwụ nke dọkịta gị gwara gị.

Pịa bọtịnụ mkpochi ahụ wee nọgide na-pịa ya ruo mgbe akara efu dị na windo nhọrọ ọnụọgụ ga-adaba na pointer na ikpere sirinji. Guo 10 ma wepụta agịga na akpụkpọ gị.

N'oge iwere ọgwụ a, jiri mgbatị aka gị wee pịa mkpịsị aka aka gị nke ọma na mkpịsị aka mkpị ogologo, na-enweghị ibitụ akụkụ ntụgharị mkpụrụ edemede sirinji, gụnyere ogwu a na-ahuta.

Ọ bụrụ n ’ịhọrọ ọgwụ were were kwụsị tupu akara akara ya na ọnụọgụ ya, ọ pụtara na ịnwetabeghị ọgwụ insulin chọrọ. Na nke a, ndị na-ahọpụta ọgwụ na-egosi ọnụ ọgụgụ nke ekwesịrị itinye tupu insulin zuru ezu.

3. Wepu agịga

Jiri nwayọ tinye eriri mpụta na agịga ma yọpụ agịga site na mkpịsị sirinji eji ejuputa.

Lelee mgbe niile na ajịpụrụ agịga ahụ. Dochie okpu nke sirinji eji eji eji dochie ihe. Mwepu nke agịga eji eme ihe dị ka nkwenye ndị ọrụ ahụike na ụkpụrụ ịdị ọcha na nke ọrịa.

Oge ọ bụla dochiri agịga, soro usoro 1B na 1D.

Ekwesịrị iji mkpụrụ mkpịsị ọrịị eji emeju tupu ị gwaa onye na-ahụ maka ahụike gị.

To Iji gbochie ọrịa, mkpịsị odere eji eji naanị mkpụrụ ga - abụrịrị otu onye ọrịa ya na ekwesighi izigara ya onye ọzọ.

In Ọ bụrụ na mmerụ ahụ nke rọba kpụrụọkụ, jiri ọgwụ antiseptik gwọọ ya, chere ruo mgbe disk ahụ akpọnwụwo kpamkpam tupu ịtọba agịga.

If Ọ bụrụ na enyo na mkpụrụedemede eji mkpofu sirinji debere ihe dị na mbụ mebiri, jiri pen sirinji debere ihe dị mbụ debere.

Before Tupu ntụtụ ọ bụla, gbaa mbọ hụ na mkpịsị ọdee eji etinyere ya ụdị ọgwụ insulin ọ bụla nke ndị ọrụ nlekọta ahụike depụtara ya.

Gụọ ma soro ntuziaka maka ojiji insulin na-aga ọgwụ. Gbaa mbọ hụ na a kwadebere mkpụrụ edemede syringe eji emeju maka iji ya na ntuziaka. Imebi usoro a ga - eji dozie mkpịsị ọrịre eji dejuru ihe eji eme ihe ga - eduga n ’iwebata insulin nke ezughị oke.

For Maka ọgwụ mgbochi ọ bụla, jiri agịga ọhụrụ. Ozugbo a gbasịrị, a ga-ewepụ ma ọ bụ kpochapụ agịga ahụ n'ụzọ na-enweghị nchebe. Ọ bụrụ na agịga dị na mkpịsị akwụkwọ a, nke a nwere ike ibute ịchiri ọnụ ma emetụta izi ezi nke dose ahụ.

Kwee dọkịta gị ma ọ bụrụ na ị na-achọpụta ọ̀tụ̀tụ̀ shuga dị iche iche nke ọbara.

Nchekwa na mkpofu

Must A ga-echerịrị mkpụrụ sirinji eji eme ihe ọ bụla ka ejiri agịga mịrị na okpu kpuchie ya mgbe niile.

Agaghị enwe ike iji mkpụrụ edemede sirinji enwere ike ịnwere ma ọ bụrụ na ọ nọghị na friji karịa oge akọwapụtara na ntuziaka maka ojiji ahụike.

With jiri akwa mmiri dee syringe. Ekwekwala pen nke ọma na mmiri.

Should A ga-echekwa mkpụrụ ndụ mịrị amị nke na-adịghị arụ ọrụ na friji n'oge okpomọkụ 2 ruo 8 Celsius.

8 Debe sirinji ndị enwere ike ịnara nke ọma tupu ụmụaka eruo.

Pose tufuo agịga ejiri na ntụaka aka ha, ma ọ bụ nke ndị ọrụ nlekọta ahụike tụrụ aro ya.

Ekwesighi ijigharị mkpụrụ edemede sirinji efu. Tụfuo mkpịsị sirinji eji eme ihe na-enweghị agịga ha na dịka ndụmọdụ dọkịta gị si dị.

Agụnyere akwụkwọ ntuziaka a na ngwugwu nwere pensọm sirinji 3 ml nke enwere ike iji dochie ya.

Syringe pen emeputa: Medsintez Plant LLC, Russia.

Mlọ ọgwụ

Ọgwụ Rosinsulin P - insulin nke mmadụ nwetara site na ihe omimi nke ihe ọmụmụ DNA na-eji ụdị nje E. coli. Ọ bụ nkwadebe insulin na-eme obere oge. Ọ na - emekọrịta otu onye na - anabata ihe n'ụsọ akpụkpọ ahụ cytoplasmic nke mkpụrụ ndụ ma mepụta ogige insulin-receptor na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthase, wdg). A na-eme ka mbelata ọbara glucose ọbara site na mmụba na njem nke intracellular ya, mmụba dị ukwuu na njigide anụ ahụ, mkpali nke lipogenesis, glycogenogenesis, mbelata ọnụego glucose sitere na imeju, wdg.

Ogologo oge nke ihe insulin na-ekpebi bụ na ọnụego mmịpụta, nke dabere n'ọtụtụ ihe (dịka ọmụmaatụ, na dose, usoro na ebe nchịkwa, ọkpụrụkpụ nke subcutaneous fat layer, dị ka ọrịa shuga mellitus), ya mere profaịlụ nke insulin na-agbanwe n'ọtụtụ mgbanwe, dịka ndị dị iche iche, na otu onye.

Profaịlụ nke imebi ihe dị n'okpuru ala (ihe dị ka ọnụ ọgụgụ): mmalite nke ime ihe dị ka nkeji iri atọ, nsonaazụ kachasị na etiti oge dị ka awa 2 na 4, oge ọrụ ahụ bụ awa 6-8.

Mlọ ọgwụ

Ndụ ọkara nke insulin site n'ọbara ọbara bụ naanị nkeji ole na ole.

Ogologo oge nke ihe insulin na-eme bụ n'ihi nzere, nke dabere na ọtụtụ ihe (dịka ọmụmaatụ, na insulin insulin, usoro na ebe nlekọta, ọkpụrụkpụ nke subcutaneous fatịlaịza na ụdị ọrịa shuga mellitus). Yabụ, ọgwụ ọgwụ insulin nke ọgwụ insulin na-enwe mgbanwe dị ukwuu n'etiti mmadụ na ibe ya.

Oke ịta (C_max) a na - enweta insulin plasma n'ime awa 1.5-2.5 mgbe nchịkwa subcutaneous gasịrị.

O nweghị ihe akpọrọ ihe ga-egbochi protein ndị amasịrị, ewezuga inye ọgwụ nje insulin (ọ bụrụ na ọ bụla).

A na-ewepụ insulinase mmadụ ma ọ bụ enzymes na-eme ka insulin na-ehichapụ ya, ikekwe site na protein disulfide isomerase.

Echere na na molekul nke insulin mmadu nwere otutu saịtị nke cleavage (hydrolysis), agbanyeghị, ọ nweghị nke metabolites guzobere n'ihi nsachapụ adịghị arụ ọrụ.

Nkera-ndu (T_1/2) a na-ekpebi n ’ọnụego nnabata nke anụ arụ. N’ihi ya, T_1/2 kama nke ahụ, ọ bụ ihe a na-amị amị, ọ bụghịkwa ihe nke iwepu insulin na plasma (T_1/2 insulin si n'ọbara bu nkeji ole na ole).

Mmụta emere egosi na T_1/2 bụ ihe dịka 2-5 awa.

Childrenmụaka na ndị nọ n'afọ iri na ụma

Ihe omuma nke ogwu Rosinsulin P na umuaka na umuaka yiri nke ndi okenye. Agbanyeghị, enwere ọdịiche dị n’etiti afọ dị iche iche n’ihe ngosipụta dịka C_max, nke na-emesi ike ọzọ mkpa nhọrọ nke otu.

Ọrịa shuga mellitus.
Ọnọdụ ọnọdụ mberede na ndị ọrịa nwere ọrịa mellitus na-arịa ọrịa ụbụrụ, yana usoro mkpụkọ metabolism.

Ime na lactation

Enweghị mgbochi ọ bụla maka ịgwọ ọrịa shuga mellitus na insulin n'oge afọ ime, ebe insulin anaghị agafe ihe mgbochi placental. Mgbe ị na-eme atụmatụ ịtụrụ ime na n’oge ya, ọ dị mkpa ime ka ọgwụgwọ shuga dị ike sie ike. Mkpa insulin na-agbadata n'oge ọnwa atọ nke mbụ nke afọ ime wee jiri nwayọ na nke abụọ na nke atọ. N'oge na mgbe amuchara nwa, ihe ndi choro insulin nwere ike igbadata nke ukwuu. N'oge na-adịghị anya a mụsịrị nwa, mkpa ọ dị insulin na-alaghachi ngwa ngwa dị ka ọ dị tupu ime ime. Enweghị mgbochi ọ bụla na ịgwọ ọrịa shuga mellitus nwere insulin n'oge a na-enye nwa ara, ebe ọ bụ na ọgwụgwọ nke nne nwere insulin dị mma maka nwa ahụ. Agbanyeghị, ịmegharị insulin na / ma ọ bụ nri nwere ike ịdị mkpa, yabụ ijiri nlezianya dị mkpa iji mee ka ihe insulin chọrọ.

Usoro onunu ogwu na nhazi

Ọgwụ Rosinsulin P bu n'obi maka usoro ntanetịime, ọgwụ mgbochi ọbara na intramuscular. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ na ụzọ e si elekọta ọgwụ ahụ n’otu n’ozi ọ bụla dabere n’ọbara glucose n’ọbara. Na nkezi, kwa ụbọchị ọgwụ a sitere na 0.3 IU / n'arọ ruo 1 IU / n'arọ nke ịdị arọ ahụ (dabere na njirimara onye ọrịa na ntinye glucose n'ọbara). Ihe a chọrọ kwa ụbọchị maka insulin nwere ike ịdị elu karịa n’ebe ndị ọrịa na - eguzogide insulin (dịka ọmụmaatụ, n’oge uto, yana n’ebe ndị ọrịa na - ebu oke ibu), ma belata obere n’ime ndị ọrịa nwere ọgwụ insulin na-emepụtagharị.

A na-enye ọgwụ ahụ nkeji iri atọ tupu nri ma ọ bụ nri nwere carbohydrates. Okpomoku nke mmanu insulin kwesiri ino na okpomoku.

Site na iji ọgwụ monotherapy, ugboro nchịkwa ya bụ ugboro 3 kwa ụbọchị (ọ bụrụ na ọ dị mkpa, ugboro 5-6 kwa ụbọchị). Na usoro ubochi gafere 0.6 IU / n'arọ, ọ dị mkpa ịbanye n'ụdị inje 2 ma ọ bụ karịa na akụkụ dị iche iche nke ahụ.

Ọgwụ Rosinsulin P bụ nke a na-ejikarị subcutaneously na mpaghara nke mgbidi ihu. A pụkwara ime inje n'apata ụkwụ, ma ọ bụ na mpaghara nwere ike iche n'ubu. Site na ntinye ọgwụ a na mpaghara mpaghara mgbidi afọ, a na-enweta mmịpụ ngwa ngwa karịa iwebata ya na mpaghara ndị ọzọ.Okwesiri igbanwe ebe igba ogwu n’etiti mpaghara anatomical iji gbochie mmepe nke lipodystrophy.

N'ime intramuscular, ọgwụ Rosinsulin P nwere ike ịnye ya naanị dika dọkịta gwara ya. Ọgwụ ndị ọkachamara n'ịgwọ ọrịa ahụ ga-eme ya.

Rosinsulin R bụ insulin na-adị mkpụmkpụ ma a na-ejikarị ya na insulin na-arụ ọrụ oge (Rosinsulin C).

Mgbe ị na-eji pensụ pensụl ọnye ọnụọgụ ọgwụ eji ejupụta tupu ọnụọgụ, ọ dị mkpa iji wepu sirinji mkpịsị na friji tupu ịmalite izi ka ọgwụ ahụ rute n ’ụlọ ahụ. Ọgwụ Rosinsulin P agaghị enwe ike ịgụta ya ma ọ bụrụ na agbajụọ ya. Ọ dị mkpa na ị ga-agbaso ntuziaka maka iji mkpụrụ akwụkwọ sirinji enyere ya.

Ọrịa concoitant, nke na-efe efe ma na-efe efe, na -emekarị ahụ insulin nwere ahụ. Ọ ga-adị mkpa imeghari dose ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa ndị akụrụ, akụrụ, ọrụ akwara, pisis gland ma ọ bụ azụ gland.

Mkpa maka ịhazigharị dose nwekwara ike ibili mgbe ị na-agbanwe mmega ahụ ma ọ bụ nri ndị ọrịa na-emebu. Imezi dose mgbe ị na-ebufe onye ọrịa n’otu ụdị insulin na nke ọzọ.

Nsonaazụ

Nsonaazụ kachasị emetụta ya na insulin bụ hypoglycemia. N'oge ọmụmụ gbasara ọgwụgwọ, yana n'oge iji ọgwụ ahụ ka ahapụchara ya na ahịa ndị ahịa, a chọpụtara na ọnọdụ hypoglycemia dị iche dabere na ndị ọrịa, usoro ọnụọgụ nke ọgwụ ahụ, yana njikwa glycemic (lee. "Nkọwa nke mmeghachi omume ọjọọ nke onwe onye").

Na nmalite ọmụmụ ọgwụ insulin, njehie na-emegharị emegharị, ụkwara akwara na mmeghachi omume na saịtị ịgba ntụtụ (gụnyere mgbu, redness, urticaria, mbufụt, hematoma, ọzịza na itching na saịtị ịgba ntụtụ) nwere ike ime. Mgbaàmà ndị a anaghị adịte aka. Ọganiihu ngwa ngwa na njikwa glycemic nwere ike iduga 'ọnọdụ nro ọria mgbu,' nke na-agbanwegharị. Enstụgharị uche na ọgwụ insulin na mmụba dị mma n'ịchịkwa metabolism metabolism nwere ike ibute ịbelata nwa oge na ọnọdụ ọrịa retinopathy na-arịa ọrịa shuga, ebe nkwalite ogologo oge na njikwa glycemic na-ebelata ohere nke inwe ọrịa mamị retinopathy.

Edepụtara ndepụta nke mmetụta ndị dị na tebụl.

Nsonaazụ niile ndị a gosipụtara n’okpuru, dabere na data nnwale, nyochara usoro nyocha dị n’usoro dịka usoro MedDRA na sistem. A na-akọwapụta ntụpọ nke nsonaazụ ndị ọzọ dịka: oge mgbe (≥ 1/10), ọtụtụ mgbe (≥ 1/100 to