Ntụziaka maka iji "Lantus Solostar": ihe mejupụtara, analogues, ọnụahịa na nyocha ndị ahịa

Lantus bụ otu n'ime ụdị analogues na-enweghị atụ nke insulin mmadụ. Enwetara site na iji glycine dochie amino acid asparagine na ọnọdụ nke 21 nke A ma gbakwunye amgin acid arginine abụọ n'ime agbụ B na ọdụ amino acid. A na-emepụta ọgwụ a site na nnukwu ụlọ ọrụ na - emepụta ọgwụ French - Sanofi-Aventis. N'ime ọtụtụ ọmụmụ, e gosipụtara na insulin Lantus abụghị naanị na-ebelata ihe ize ndụ nke hypoglycemia ma e jiri ya tụnyere ọgwụ ọgwụ NPH, kamakwa ọ na-eme ka metabolism metabolism dịkwuo mma. N'okpuru ebe a bụ ntuziaka dị mkpirikpi maka ojiji na nyocha nke ndị ọrịa mamịrị.

Mmekọrịta na ọgwụ ndị ọzọ

Enwere ọgwụ ọgwụ na-emetụta metabolism metabolism, ebe ọ na-abawanye ma ọ bụ belata mkpa ịchọrọ insulin.

Belata shuga: ndị na - egbochi ọgwụ antidiabetic, sulfonamides, ACE inhibitors, salicylates, angioprotector, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Mmụba shuga: homonụ thyroid, mkpụrụ ndụ akwara, ọrịa ọmịiko, ọgwụ mgbochi ụbụrụ, ọgwụ phenothiazine, ndị na-egbochi nchebe.

Substancesfọdụ ihe nwere mmetụta hypoglycemic na mmetụta hyperglycemic. Ndị a gụnyere:

• ihe mgbochi beta na nnu nke lithium,
• mmanya
• clonidine (ọgwụ antihypertensive).

Ihe ngbanwe

1. Amachibidoro iji ndị ọrịa nwere ekweghị na insulin glargine ma ọ bụ ihe inyeaka.
2. Hypoglycemia.
3. Ọgwụ ketoacidosis nke na-arịa ọrịa mamịrị.
4. Undermụaka n’agbata afọ abụọ.

Enwere ike ịmeghachi omume na-adịghị mma, ntuziaka a na-ekwu na enwere ike:

• lipoatrophy ma ọ bụ lipohypertrophy,
• Mmeghachi omume nfụkasị (ụbụrụ Quincke, ụkwara ume ọkụ, bronchospasm),
• olu mgbu na oge n’ime ahụ sodium ion,
• dysgeusia na nkwarụ anya.

Ntughari na Lantus si na insulin ozo

Ọ bụrụ na ndị ọrịa mamịrị ji insulins oge obere, mgbe ahụ, mgbe ị na-agbanye Lantus, a ga-agbanwe usoro onunu ogwu na usoro ọgwụ ahụ. Ekwesịrị ime mgbanwe insulin naanị na ụlọ ọgwụ.

N’ọdịnihu, dọkịta na-elele shuga, ndụ onye ọrịa, ibu ibu ma dozie ọnụ ọgụgụ nkeji enyere aka. Mgbe ọnwa atọ gachara, aga-enyocha ịdị irè nke usoro ọgwụ edepụtara site na nyocha nke gemoclobin glycated.

Ntụziaka vidiyo:

Akụkọ banyere otu n'ime ndị na - agụ akwụkwọ anyị, Inga Eremina:

Ibu m kacha nwee obi mgbawa, m dị ka ndị na-agba mgba atọ 3, nke bụ 92kg.

Kedu otu esi ewepụ oke ibu kpamkpam? Kedu otu esi anagide mgbanwe hormonal na oke ibu? Ma ọ dịghị ihe na-emebi ma ọ bụ ntorobịa mmadụ dịka mmadụ ya.

Ma ihe ị ga-eme iji felata? Surgerywa ahụ ọyịre laser? Achọpụtara m - opekata mpe ise. Usoro nchekwa - LPG ịhịa aka n'ahụ, cavitation, RF na-eweli elu, myostimulation? Obere ego karịa - usoro ahụ na-efu site na 80,000 rubles na onye ọkachamara n'ihe banyere nri. Can nwere ike gbaa mbọ gbaa ọsọ ma ọ bụrụ na ị na-enwe ara.

Na mgbe ị ga-ahụ oge a niile? Ee ma ka dịkwa oke ọnụ. Karịsịa ugbu a. Ya mere, maka onwe m, ahọpụtara m usoro ọzọ.

Na Russia, a na-ebugharị ndị ọrịa shuga niile na-akpata insulin n'ike n'ike site na Lantus gaa Tujeo. Dika ihe omumu emere, ogwu ohuru nwere obere nsogbu nke ịmalite hypoglycemia, mana na omume otutu ndi mmadu na-eme mkpesa na mgbe ha gbanyere Tujeo, ha na-ama elu nke ukwuu, ya mere a na-amanye ha ịzụta insulin Lantus Solostar n'onwe ha.

Levemir bụ ọgwụ dị oke mma, mana o nwere ihe dị iche na-arụ ọrụ, ọ bụ ezie na oge ọrụ ga-adịkwa awa iri abụọ na anọ.

Aylar ezuteghị insulin, ntuziaka a na-ekwu na nke a bụ Lantus otu, mana onye nrụpụta dị ọnụ ala.

Insulin Lantus n'oge di ime

Emebeghị nnyocha ọmụmụ gbasara Lantus nke nwere ụmụ nwanyị dị ime. Dabere na akwụkwọ ndị na-abụghị isi, ọgwụ ahụ anaghị emetụta ihe ọ bụla ime na nwa ya.

Emere nyocha na ụmụ anụmanụ, n'oge nke gosipụtara na insulin glargine enweghị mmetụta na-egbu egbu na ọrụ omumu.

Enwere ike ịkọwa Lantus Solostar dị ime ma ọ bụrụ na insulin NPH adịghị arụ ọrụ. Ndị nne na-amụ n’ọdịnihu kwesịrị inyocha shuga ha, n’ihi na n’oge ọnwa atọ mbụ, mkpa insulin nwere ike ibelata, n’oge nke abụọ na nke atọ.

Atụla egwu inye nwa ara; na ntuziaka enweghị ozi nke Lantus nwere ike ịbanye na mmiri ara.

Ndụ nchekwa nke Lantus bụ afọ 3. Youkwesiri ịchekwa ebe gbara ọchịchịrị nke ìhè anyanwụ na ogo 2 ruo 8. Ọtụtụ mgbe ebe kachasị adabara bụ friji. Na nke a, jide n'aka na ị ga-eleba anya na usoro ọnọdụ okpomọkụ, n'ihi na a machibidoro ịhapụ insulin Lantus insulin!

Site na ojiji mbụ, enwere ike ịchekwa ọgwụ ahụ maka otu ọnwa na ebe gbara ọchịchịrị na-adịghị elu karịa ogo 25 (ọ bụghị na friji). Ejila insulin emebiela.

Ebe ịzụta, ọnụahịa

Ejiri Lantus Solostar na-akwụghị ụgwọ site na ọgwụ endocrinologist deere ya. Ma ọ na - eme na onye ọrịa mamịrị ga - azụta ọgwụ a n'onwe ya n'ụlọ ahịa ọgwụ. Ọnụ ego insulin bụ 3300 rubles. Na Ukraine, enwere ike ịzụta Lantus maka 1200 UAH.

Ndị na-arịa ọrịa shuga na-ekwu na ọ bụ insulin dị mma nke ukwuu, na a na-egbochi shuga ha n'usoro etu o kwesiri. Lee ihe ndị mmadụ kwuru gbasara Lantus:

Ọtụtụ na-ahapụ naanị nyocha dị mma. Ọtụtụ mmadụ kwuru na Levemir ma ọ bụ Tresiba ka mma karịa maka ha.

Lantus Solostar

Lantus solostar 100ed / ml 3ml 5 PC. ihe ngwọta maka nchịkwa subcutaneous nke katrij. na sp.-aka.

Sanofi (Russia) Nkwadebe: Lantus solostar

Analogs sitere na insulin nke otu

Actrapid nm 100 u / milimita 10 ml ntụtụ

Nkwadebe Novo Nordisk A / C (Denmark): Actrapid nm

Humalog 100me / ml 3ml 5 PC. osisa nye nnabata nnabata

Eli Lilly East S.A. (France) Nkwadebe: Humalog

Biosulin n 100me / ml 3ml 5 PC. nkwusioru maka ochichi nke okpukpo okpukpo. na sp.-aka.

Pharmstandard Rx (Russia) Nkwadebe: Biosulin n

Levemir flekspen 100ed / ml 3ml 5 PC. rr-p maka usoro nchịkwa ibe okpuru ala. na sp.-aka.

Nkwadebe Novo Nordisk A / C (Denmark): Levemir flekspen

Analogs site na udi Ọrịa shuga

5 mg maninil 120 pcs. ọgwụ

Nkwadebe Berlin Chemie (Germany): Maninil

Gliformin 1000mg 60 PC. mbadamba ihe mkpuchi

Akrikhin (Russia) Nkwadebe: Gliformin

Glurenorm 30mg 60 PC. ọgwụ

Beringer Ingelheim Pharma (Germany) Nkwadebe: Glurenorm

Siofor 500mg 60 PC. mbadamba mkpuchi

Nkwadebe Berlin Chemie (Germany): Siofor 500

Siofor 850mg 60 PC. mbadamba mkpuchi

Nkwadebe nke Berlin Chemie (Germany): Siofor 850

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Ngwọta maka nchịkwa sc bụ doo anya, enweghị agba ma ọ bụ ihe fọrọ nke nta enweghị agba.

Ndị ọkachamara: metacresol (m-cresol) - 2.7 mg, zinc chloride - 0.0626 mg (nke kwekọrọ na 30 μg zinc), glycerol (85%) - 20 mg, sodium hydroxide - ruo pH 4.0, hydrochloric acid - ruo pH 4.0, mmiri d / na - ruo 1 ml.

3 ml - katrized site na enyo enyo, enweghị iko (ụdị nke m), nke etinyere na pensụl sSeSSSS (5) - ngwugwu kaadiboodu nwere ihe njiri kaadiboodu.

Omume ọgwụ

Ọnọdụ ụmụaka na-eme egwuregwu!

Ihe na-arụ ọrụ nke Lantus bụ insulin glargine. A na - enweta ya site na ntụgharị mkpụrụ ndụ site na iji ụdị k-12 nke nje Escherichia coli. N'ebe a na-anọpụ iche, ọ na-agbachasị agbari, na ọgwụ acidic ka ọ na-agbari site na ịmepụta microprecippre, nke na-ewepụta insulin mgbe niile. N'ihi nke a, Lantus nwere profaịlụ dị mma na-adịgide ruo awa 24.

Akụkọ banyere otu n'ime ndị na - agụ akwụkwọ anyị Alina R.

Ego anọwo na-abụ isi ihe m na-eche. N'ihi nke a, enwere m ụyọkọ ogige. Agụrụ m onwe m dị ka onye na-enweghị isi, nsogbu dị na ọrụ na ndụ m. Agbanyeghị, ekpebiri m na m ka chọrọ enyemaka onwe onye. Mgbe ụfọdụ ọ dị ka okwu ahụ dị na gị onwe gị, ọdịda niile bụ naanị nsonazụ nke ike ọjọọ, anya ọjọọ, ma ọ bụ mmụọ ọjọọ ọzọ.

O siri ike inwe obi uto na aru oru ego dika 26t.r. mgbe ikwesiri ikwu ugwo puku 11,000. Kedu ihe tụrụ m n’anya mgbe ndụ m niile gbanwere na mberede n'otu ntabi anya. Enweghị m ike iche n'echiche na ọ ga - ekwe omume ị nweta ego buru ibu nke na ụfọdụ ihe dị na ntanetị nke mbụ lere anya nwere ike nwee ụdị mmetụta. Ihe niile bidoro site n'eziokwu bụ na m nyere otu onye iwu.

Isi ihe dị na nkà mmụta ọgwụ:

• Ngwa ngwa adsorption na profaịlụ na-enweghị atụ n'ime awa 24.
• Mgbachi nke proteolysis na lipolysis na adipocytes.
• Akụkụ nọ n'ọrụ na-ekekọta ndị na - anabata insulin ugboro 5-8.
• Usoro nchịkwa glucose metabolism, igbochi ịkpụbe glucose na imeju.

N'ime 1 ml Lantus Solostar dere:

• 3.6378 mg nke insulin glargine (n'ihe gbasara 100 IU nke insulin mmadụ),
• 85% glycerol
• mmiri maka ịgba ntụtụ
• hydrochloric ndọpụ acid,
• m-cresol na sodium hydroxide.

Lantus - uzo puru iche maka injection sc, di n’udi:

• katọn maka usoro OptiKlik (5pcs kwa mkpọ),
• 5 pensụl pensụl Lantus Solostar,
• Penti OptiSet na ngwugwu 5 pcs. (nzọụkwụ 2 nkeji),
• 10 ml vials (1000 nkeji n'otu vial).

Ihe ngosi maka ojiji

1. Ndị okenye na ụmụaka sitere na afọ 2 nwere ọrịa shuga 1.
2. 2dị shuga abụọ nke ọrịa mellitus (n'ihe banyere adịghị ike nke mbadamba).

N’ime oke ibu, ọgwụgwọ ejikọtara ọnụ dị irè - Lantus Solostar na Metformin.

Mmekọrịta na ọgwụ ndị ọzọ

Enwere ọgwụ ọgwụ na-emetụta metabolism metabolism, ebe ọ na-abawanye ma ọ bụ belata mkpa ịchọrọ insulin.

Belata shuga: ndị na - egbochi ọgwụ antidiabetic, sulfonamides, ACE inhibitors, salicylates, angioprotector, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Mmụba shuga: homonụ thyroid, mkpụrụ ndụ akwara, ọrịa ọmịiko, ọgwụ mgbochi ụbụrụ, ọgwụ phenothiazine, ndị na-egbochi nchebe.

Substancesfọdụ ihe nwere mmetụta hypoglycemic na mmetụta hyperglycemic. Ndị a gụnyere:

• ihe mgbochi beta na nnu nke lithium,
• mmanya
• clonidine (ọgwụ antihypertensive).

Ihe ngbanwe

1. Amachibidoro iji ndị ọrịa nwere ekweghị na insulin glargine ma ọ bụ ihe inyeaka.
2. Hypoglycemia.
3. Ọgwụ ketoacidosis nke na-arịa ọrịa mamịrị.
4. Undermụaka n’agbata afọ abụọ.

Enwere ike ịmeghachi omume na-adịghị mma, ntuziaka a na-ekwu na enwere ike:

• lipoatrophy ma ọ bụ lipohypertrophy,
• Mmeghachi omume nfụkasị (ụbụrụ Quincke, ụkwara ume ọkụ, bronchospasm),
• olu mgbu na oge n’ime ahụ sodium ion,
• dysgeusia na nkwarụ anya.

Ntughari na Lantus si na insulin ozo

Ọ bụrụ na ndị ọrịa mamịrị ji insulins oge obere, mgbe ahụ, mgbe ị na-agbanye Lantus, a ga-agbanwe usoro onunu ogwu na usoro ọgwụ ahụ. Ekwesịrị ime mgbanwe insulin naanị na ụlọ ọgwụ.

N’ọdịnihu, dọkịta na-elele shuga, ndụ onye ọrịa, ibu ibu ma dozie ọnụ ọgụgụ nkeji enyere aka. Mgbe ọnwa atọ gachara, aga-enyocha ịdị irè nke usoro ọgwụ edepụtara site na nyocha nke gemoclobin glycated.

Ntụziaka vidiyo:

Akụkọ banyere otu n'ime ndị na - agụ akwụkwọ anyị, Inga Eremina:

Ibu m kacha nwee obi mgbawa, m dị ka ndị na-agba mgba atọ 3, nke bụ 92kg.

Kedu otu esi ewepụ oke ibu kpamkpam? Kedu otu esi anagide mgbanwe hormonal na oke ibu? Ma ọ dịghị ihe na-emebi ma ọ bụ ntorobịa mmadụ dịka mmadụ ya.

Ma ihe ị ga-eme iji felata? Surgerywa ahụ ọyịre laser? Achọpụtara m - opekata mpe ise. Usoro nchekwa - LPG ịhịa aka n'ahụ, cavitation, RF na-eweli elu, myostimulation? Obere ego karịa - usoro ahụ na-efu site na 80,000 rubles na onye ọkachamara n'ihe banyere nri. Can nwere ike gbaa mbọ gbaa ọsọ ma ọ bụrụ na ị na-enwe ara.

Na mgbe ị ga-ahụ oge a niile? Ee ma ka dịkwa oke ọnụ. Karịsịa ugbu a. Ya mere, maka onwe m, ahọpụtara m usoro ọzọ.

Na Russia, a na-ebugharị ndị ọrịa shuga niile na-akpata insulin n'ike n'ike site na Lantus gaa Tujeo. Dika ihe omumu emere, ogwu ohuru nwere obere nsogbu nke ịmalite hypoglycemia, mana na omume otutu ndi mmadu na-eme mkpesa na mgbe ha gbanyere Tujeo, ha na-ama elu nke ukwuu, ya mere a na-amanye ha ịzụta insulin Lantus Solostar n'onwe ha.

Levemir bụ ọgwụ dị oke mma, mana o nwere ihe dị iche na-arụ ọrụ, ọ bụ ezie na oge ọrụ ga-adịkwa awa iri abụọ na anọ.

Aylar ezuteghị insulin, ntuziaka a na-ekwu na nke a bụ Lantus otu, mana onye nrụpụta dị ọnụ ala.

Insulin Lantus n'oge di ime

Emebeghị nnyocha ọmụmụ gbasara Lantus nke nwere ụmụ nwanyị dị ime. Dabere na akwụkwọ ndị na-abụghị isi, ọgwụ ahụ anaghị emetụta ihe ọ bụla ime na nwa ya.

Emere nyocha na ụmụ anụmanụ, n'oge nke gosipụtara na insulin glargine enweghị mmetụta na-egbu egbu na ọrụ omumu.

Enwere ike ịkọwa Lantus Solostar dị ime ma ọ bụrụ na insulin NPH adịghị arụ ọrụ. Ndị nne na-amụ n’ọdịnihu kwesịrị inyocha shuga ha, n’ihi na n’oge ọnwa atọ mbụ, mkpa insulin nwere ike ibelata, n’oge nke abụọ na nke atọ.

Atụla egwu inye nwa ara; na ntuziaka enweghị ozi nke Lantus nwere ike ịbanye na mmiri ara.

Ndụ nchekwa nke Lantus bụ afọ 3. Youkwesiri ịchekwa ebe gbara ọchịchịrị nke ìhè anyanwụ na ogo 2 ruo 8. Ọtụtụ mgbe ebe kachasị adabara bụ friji. Na nke a, jide n'aka na ị ga-eleba anya na usoro ọnọdụ okpomọkụ, n'ihi na a machibidoro ịhapụ insulin Lantus insulin!

Site na ojiji mbụ, enwere ike ịchekwa ọgwụ ahụ maka otu ọnwa na ebe gbara ọchịchịrị na-adịghị elu karịa ogo 25 (ọ bụghị na friji). Ejila insulin emebiela.

Ebe ịzụta, ọnụahịa

Ejiri Lantus Solostar na-akwụghị ụgwọ site na ọgwụ endocrinologist deere ya. Ma ọ na - eme na onye ọrịa mamịrị ga - azụta ọgwụ a n'onwe ya n'ụlọ ahịa ọgwụ. Ọnụ ego insulin bụ 3300 rubles. Na Ukraine, enwere ike ịzụta Lantus maka 1200 UAH.

Ndị na-arịa ọrịa shuga na-ekwu na ọ bụ insulin dị mma nke ukwuu, na a na-egbochi shuga ha n'usoro etu o kwesiri. Lee ihe ndị mmadụ kwuru gbasara Lantus:

Ọtụtụ na-ahapụ naanị nyocha dị mma. Ọtụtụ mmadụ kwuru na Levemir ma ọ bụ Tresiba ka mma karịa maka ha.

Lantus Solostar

Lantus solostar 100ed / ml 3ml 5 PC. ihe ngwọta maka nchịkwa subcutaneous nke katrij. na sp.-aka.

Sanofi (Russia) Nkwadebe: Lantus solostar

Analogs sitere na insulin nke otu

Actrapid nm 100 u / milimita 10 ml ntụtụ

Nkwadebe Novo Nordisk A / C (Denmark): Actrapid nm

Humalog 100me / ml 3ml 5 PC. osisa nye nnabata nnabata

Eli Lilly East S.A. (France) Nkwadebe: Humalog

Biosulin n 100me / ml 3ml 5 PC. nkwusioru maka ochichi nke okpukpo okpukpo. na sp.-aka.

Pharmstandard Rx (Russia) Nkwadebe: Biosulin n

Levemir flekspen 100ed / ml 3ml 5 PC. rr-r maka nchịkwa subcutaneous nke katọndụ. na sp.-aka.

Nkwadebe Novo Nordisk A / C (Denmark): Levemir flekspen

Analogs site na udi Ọrịa shuga

5 mg maninil 120 pcs. ọgwụ

Nkwadebe Berlin Chemie (Germany): Maninil

Gliformin 1000mg 60 PC. mbadamba ihe mkpuchi

Akrikhin (Russia) Nkwadebe: Gliformin

Glurenorm 30mg 60 PC. ọgwụ

Beringer Ingelheim Pharma (Germany) Nkwadebe: Glurenorm

Siofor 500mg 60 PC. mbadamba mkpuchi

Nkwadebe Berlin Chemie (Germany): Siofor 500

Siofor 850mg 60 PC. mbadamba mkpuchi

Nkwadebe nke Berlin Chemie (Germany): Siofor 850

LANTUS SoloStar

Linlọ ọgwụ na ọgwụ ọgwụ

Ihe eji arụ ọrụ

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Ngwọta maka nchịkwa sc bụ doo anya, enweghị agba ma ọ bụ ihe fọrọ nke nta enweghị agba.

Ndị ọkachamara: metacresol (m-cresol) - 2.7 mg, zinc chloride - 0.0626 mg (nke kwekọrọ na 30 μg zinc), glycerol (85%) - 20 mg, sodium hydroxide - ruo pH 4.0, hydrochloric acid - ruo pH 4.0, mmiri d / na - ruo 1 ml.

3 ml - katrized site na enyo enyo, enweghị iko (ụdị nke m), nke etinyere na pensụl sSeSSSS (5) - ngwugwu kaadiboodu nwere ihe njiri kaadiboodu.

Omume ọgwụ

Insulin glargine bu ihe nlele nke insulin nke mmadu nwetara site na ntughari site na nje bacteria nke umu anakpo Escherichia coli (nje K12) ma nwekwaa olu di ala na onodu di iche.

Dịka akụkụ nke ọgwụ Lantus SoloStar, insulin glargine na-agbachasị kpamkpam, nke mmeghachi nke acid nke ihe ngwọta maka injection (pH 4) na-ahụ maka ya. Mgbe iwebata na abụba subcutaneous, a na-ewepụ ihe ndị acidic nke ihe ngwọta, nke na-eduga na ntinye microprecipitate, site na nke a na-ewepụta insulin glargine obere oge, na-enye profaịlụ dị mma (na-enweghị oke) nke usoro oge ịta ahụhụ, yana ọgwụ ogologo.

Insulin glargine bụ metabolized abụọ metabolites na-arụ ọrụ, M1 na M2.

Nkwukọrịta na ndị na - anabata insulin: njikọ nke njikọ nke insulin na - anabata ya na insulin glargine na metabolites ya bụ M1 na M2 yiri nke ahụ na insulin mmadụ, ya mere insulin glargine nwere ike mepụta nsonaazụ ndu yiri nke insulin endogenous.

Ọrụ kachasị mkpa nke insulin na analogues ya, gụnyere na insulin glargine, bụ usoro nke usoro glucose metabolism. Insulin na anaakpo ya na –ebelata nnabata nke glucose n’ime ọbara, na - akpali nnabata nke glucose site na uru anụ ahụ (ọkachasị akwara na akwara adi adi) ma na - egbochi imeju glucose na umeji. Insulin na - egbochi lipolysis na adipocytes ma gbochie proteinolysis, ebe ọ na - abawanye njikọ protein.

Ogologo oge insulin glargine na-emetụta ọgwụ na-ebelata ogo ihe ọ na-eme, na-enye ohere iji ọgwụ ahụ mee ihe 1 oge / ụbọchị. Mgbe sc nchịkwa, mmalite nke ihe ọ na-eme, na nkezi, mgbe elekere 1. Ogologo oge ọ ga - eme bụ awa 24, kachasị kacha bụ awa 29. Ogologo oge insulin na analogues, dị ka insulin glargine, nwere ike ịdị iche iche na ndị ọrịa dị iche iche ma ọ bụ n'otu otu ime.

Egosipụta ịdị irè nke ọgwụ Lantus SoloStar na ụmụaka karịrị afọ 2 na-arịa ụdị ọrịa shuga 1. N'ime ụmụaka dị afọ 2-6, ọnọdụ nke hypoglycemia nwere ngosipụta nke akụrụngwa mgbe ị na-eji insulin glargine dị ntakịrị oge ma n'ehihie ma n'abalị jiri ya were insulin-isofan (karị, na nkezi 25.5 nke ọhụụ na 33 nke otu onye ndidi rue otu afọ).

N'ime afọ ise nke ndị ọrịa nwere ụdị ọrịa shuga 2 dị n'ọrịa, enweghị ọdịiche pụtara ìhè na ọganihu nke ọrịa mamịrị na ọrịa insulin glargine ma e jiri ya tụnyere insulin-isophan.

Mmekọrịta ya na ndị na - anabata insulin dị ka uto ihe 1 (IGF-1): mmekọrita nke insulin glargine maka ihe nnabata nke IGF-1 dị ihe dị ka ugboro 5-8 karịa nke insulin mmadụ (mana ihe dị ka ugboro 70-80 dị ala karịa nke IGF-1), N'otu oge, na iji ya na insulin mmadụ, metabolism nke insulin glargine M1 na mmekọrịta M2 maka ihe nnabata nke IGF-1 dị obere.

Ngụkọta ọgwụgwọ insulin (insulin glargine na metabolites ya), kpebisiri ike na ndị ọrịa nwere ụdị ọrịa shuga 1 nke ọrịa mellitus, gbadara ala karịa ịchere achọrọ maka ọkara nke ejikọtara ọnụ na ndị na-anabata IGF na ntinye nke ụzọ mitogenic proliferative way nke sitere na ndị na-anabata IGF-1. Ọkpụkpọ anụ ahụ nke IGF-1 nwere ike ime ka ụzọ ụzọ protinerative mitogic rụọ ọrụ, agbanyeghị, usoro nnabata insulin na-ekpebi n'oge ọgwụgwọ insulin, gụnyere ọgwụgwọ na Lantus SoloStar, dịkarịsịrị ala karịa ọnụ ọgụgụ ọgwụ achọrọ iji rụọ ọrụ mitogenic proliferative wayway.

Ọmụmụ ihe ọmụmụ ORIGIN (Mbelata nsonaazụ na Mkpokọta Glargine na Ntaneti) bụ ọmụmụ mba ụwa, ọmụmụ ihe, enweghị usoro emere na ndị ọrịa dị 12,537 nwere nnukwu nsogbu nke ịmalite ọrịa obi yana ọrịa glucose na-ebu ọnụ (NGN), nnabata glucose na-adịghị mma (NTG) ma ọ bụ mmalite mmalite. ụdị ọrịa shuga 2. E kewapụrụ ndị sonyere n'ọmụmụ ihe ahụ gaa otu (1: 1): otu ndị ọrịa na-anata insulin glargine (n = 6264), nke akpọrọ aha tupu ya abanye n'ọbara glucose efu (GKN) ≤5.3 mmol, yana otu ndị ọrịa na-anata ọgwụgwọ ọkọlọtọ (n = 6273) )

Ihe ntughari nke mbu bu ihe omumu tupu oburu iku obi, ihe mbu nke obughi igba myocardial infarction ma obu onwu anaghi egbu egbu, ihe nke abuo bu oge tupu nsogbu mbu nke ihe obula di n’elu ma obu n’iru usoro nke ịmụgharị (akwara, carotid ma ọ bụ akwara akwara). , ma ọ bụ tupu ụlọ ọgwụ maka mmepe nke nkụda obi.

Obere pere mpe bụ ọnwụ maka ebumnuche ọ bụla yana nchịkọta ihe microvascular.

Ọmụmụ ihe ọmụmụ ORIGIN gosipụtara na ọgwụgwọ insulin glargine ma e jiri ya tụnyere ọgwụgwọ hypoglycemic ọkọlọtọ agbanweghị ihe ize ndụ nke ọrịa obi ma ọ bụ ọnwụ obi, enweghị ọdịiche na ọnụego nke akụkụ ọ bụla nke mejupụtara isi njedebe, ọnwụ site na ihe niile kpatara ya, ihe na-egosi jikọtara ọnụ nke microvascular pụta. .

Na mbido ọmụmụ a, median Hb A1c nke etiti bụ 6.4%. Hkpụrụ ntụgharị nke Hb A1c nke median n'oge ọgwụgwọ nọ na 5.9-6.4% na insulin glargine na 6.2-6.6% na ọkọlọtọ ọgwụgwọ n'oge oge nlele ahụ.

N'ime ìgwè ndị ọrịa na-anata insulin glargine, ọnọdụ nke nnukwu hypoglycemia bụ 1.05 nke ọ bụla n'ime afọ 100 nke ọgwụgwọ, yana n'ime ndị ọrịa natara usoro hypoglycemic usoro 0.3 nke ngosi afọ 100 afọ nke ọgwụgwọ. Ọnọdụ nke hypoglycemia dị nwayọ bụ 7.71 ngosipụta kwa afọ afọ nke ọgwụgwọ na otu nke ndị ọrịa na-anata insulin glargine, yana 2.44 nke ọhụụ na afọ 100 nke usoro ọgwụgwọ na otu ndị ọrịa na-anata hypoglycemia nkịtị. N'ime ọmụmụ afọ 6, 42% nke ndị ọrịa nọ na insulin glargine otu egosighi ikpe ọ bụla nke hypoglycemia.

Ọdịiche nke mgbanwe mgbanwe n’arụ ahụ ma e jiri ya tụnyere nsonaazụ na nleta ọgwụgwọ nke ikpeazụ bụ 2.2 n'arọ dị elu na insulin glargine otu karịa na otu usoro ọgwụgwọ.

Mpempe usoro onunu ogwu

Ntụtụ 100 U / ml

1 ml nke ihe ngwọta nwere:

bekee na-arụ ọrụ: insulin glargine NOE 901 - 3.6378 mg (100 PIECES).

ndị mgbe ochie: metacresol, chloride zinc, glycerin (85%), sodium hydroxide, acid hydrorated, mmiri maka injection.

Na-enweghị ntụ ma ọ bụ mmiri mmiri na-enweghị agba.

Ngwongwo ogwu

N'iji ya tụnyere NPH-insulin nke mmadụ, insulin insulin n'ihe ọmụmụ ahụike yana ndị ọrịa nwere ọrịa shuga mgbe nchịkwa insulin glargine gosipụtara nwayọ nwayọ ma nwekwaa ogologo oge, yana enweghị oke. Ya mere, nnabata ndị ahụ dabere na profaịlụ nke oge ọgwụ nke ọrụ insulin glargine. Ihe osise 1 na-egosi profaịlụ ọrụ nke insulin glargine na NPH-insulin n'oge oge. Site na ntinye nke otu ugboro kwa ụbọchị, a na-enweta ntinye uche nke ịlele insulin glargine n'ime mkpụrụ ụbọchị 2-4 n’ụbọchị mbụ ọ bụla. Site na nchịkwa ọgbụgba n'ime ọbara, ọkara ndụ nke insulin glargine na insulin nke mmadụ yiri.

Mgbe agwara Lantus subcutaneous na ndị ọrịa nwere ọrịa mellitus, insulin glargine bụ metabolized ngwa ngwa na njedebe nke polypeptide beta yinye iji mepụta metabolites abụọ na-arụ ọrụ M1 (21A-Gly-insulin) na M2 (21A-Gly-des-30B-Thr insulin). Na plasma, isi ihe na-ekesa bụ metabolite M1. Mwepu nke metabolite M1 na-abawanye dabere na usoro nke Lantus enyere.

Ngwọta ọgwụ na ọgwụ na-egosi na nsonaazụ nke injection nke Lantus bụ nke dabere na mwepu nke metabolic M1. Achọpụtaghị insulin glargine na M2 metabolite n'ọtụtụ ndị ọrịa, mgbe a hụrụ ha, ntinye uche ha bụ n'efu na usoro Lantus edepụtara.

N'ime ule nyocha, nyocha nke usoro ọmụmụ nke afọ na okike egosipụtaghị ọdịiche ọ bụla na arụmọrụ yana nchekwa n'etiti ndị ọrịa e mesoro insulin glargine na ọnụ ọgụgụ ndị gụrụ akwụkwọ.

A na-enyocha ọgwụ Pharmacokinetics n'ime ụmụaka dị afọ 2 ruo afọ isii na-arịa ụdị ọrịa shuga 1 n'otu ọmụmụ ụlọ ọgwụ (lee "Pharmacodynamics"). A na-atụle ọ̀tụ̀tụ̀ plasma nke insulin glargine na obere metabolites ya M1 na M2 na ụmụaka e ji insulin glargine gwọọ, a chọpụtara na ihe ndọta plasma yiri samata ndị okenye, ihe akaebe na-akwado mmụba nke insulin glargine ma ọ bụ metabolites ya. na nchịkwa ogologo oge adịghị.

Insulin glargine bụ analogue nke insulin mmadụ, nke emere iji nwee obere solubility na pH. Ọ na-agbanye mmiri kpamkpam na pic acid nke Lantus® Injection (pH 4). Mgbe ọchịchị subcutaneous gasịrị, a na-ewepụ acidic acid, na-eme ka e guzobe microprecipitate, site na nke a na-ewepụta insulin glargine na obere obere, na-enye nsonaazụ oge, nke na-enweghị nsogbu, na-atụgharị anya na ogologo oge nke ime ihe.

Ihe jikọrọ insulin na-anabata ya: n’ime nyocha nke vitro na-egosi na ịdị n’etiti insulin glargine na metabolites M1 na M2 maka ndị na - anabata insulin na - eme ka otu insulin si arụ ọrụ.

Ihe jikọrọ IGF-1 na nnabata: njikọta insulin glargine maka IGF-1 na-anabata mmadụ bụ ihe dị ka ugboro 5-8 karịa nke insulin mmadụ (mana ihe ruru 70-80 ugboro dị ala karịa IGF-1), ebe M1 metabolites na M2 jikọtara ọnụ na ntanetị nke IGF-1 na obere mmekọrịta dị ntakịrị ma e jiri ya tụnyere insulin mmadụ.

Nchikota ọgwụgwọ insulin (insulin glargine na metabolites ya), kpebisiri ike na ndị ọrịa nwere ụdị ọrịa shuga 1 nke ọrịa mellitus, dị obere ka a ga-achọ ka ọkara gafee nzaghachi nke nnata IGF-1 na ịgbaso ụzọ ụzọ nnabata nke mitogenic nke nnabata nke IGF-1 na-anabata ihe. . Ọkpụkpọ anụ ahụ nke IGF-1 nwere ike ịgbalite ụzọ mitogenic proliferative way, agbanyeghị, usoro ọgwụgwọ ọgwụgwọ ekpebisiri ike n'oge ọgwụgwọ insulin, gụnyere ọgwụgwọ Lantus, dịkarịsịrị ala karịa ọnụ ọgụgụ ọgwụ ọgwụ achọrọ iji rụọ ọrụ IGF-1.

Ọrụ bụ isi nke insulin, gụnyere insulin glargine, bụ ịhazi metabolism metabolism. Insulin na ihe analogues ya na -ebelata ogo glucose ọbara site na ịba ụba glucose na anụ ahụ na-emetụta, ọkachasị akwara na akwara adize, yana site na-egbochi imepụta glucose na umeji. Insulin na - egbochi lipolysis na adipocytes, na - egbochi proteolysis ma na - akwalite njikọ protein. Ọmụmụ ọgwụ na ọmụmụ ọgwụ egosila na insulin glargine nke insulin na insulin na-ahụ maka ụmụ mmadụ nwere nha anya mgbe a na-ahụ otu usoro onunu ogwu. Dị ka ọ dị insulins niile, mmega ahụ na ihe ndị ọzọ nwere ike imetụta oge ihe insulin glargine na-eme.

Mpempe mwepụta

Insulin dị na pensụl. Nke a bụ ụdị adaba maka ndị ọrịa shuga, ebe ọ bụ na enwere ike ịme injections ọ bụghị naanị n'ụlọ, kamakwa n'ụlọ. Site n'enyemaka nke mkpịsị ode akwụkwọ, ọ dị mfe iji dozie usoro ọgwụgwọ ọ bụla, yabụ ikpe ịdoụbiga mmanya ókè bụ ihe dị ụkọ. Ihe ngwugwu ahụ nwere katrized 5 nke 3 ml. A na-etinye ọgwụ ahụ na igbe kaadi ahụ, enwerekwa nkuzi maka iji ya na nkọwa zuru oke banyere otu esi eji ngwaahịa a. Onye mepụtara ọgwụ ahụ bụ Frankfurt am Main Germany, onye Russia mepụtara ọgwụ ahụ bụ ZAO Sanofi-Aventis Vostok, Oryol Oblast.

Pharmacodynamics na pharmacokinetics

A na-emepụta ọgwụ ahụ n'ụzọ dị otú ahụ nke na ọ nwere obere solubility na mpaghara acidic na-anọpụ iche. Mmiri injection ọ na-agbaze nke ọma kpamkpam. Mgbe ogwu ogbugba gasịrị, ọgwụ acidic ahụ na-anọpụ iche, ọgwụ ahụ wee dozie n'ụdị microcrystals, nke na-eji nwayọ banye n'ọbara. Nke a na-akọwa usoro o toro ogologo. Ngwakọta insulin na-eme ka uru glucose dị nro site na anụ ahụ, karịchaa akwara ọkpụkpụ na akwara abụba, ma belata imeju glucose site na imeju. Ya mere, mbelata nke glucose ọbara. Ọ bụrụ na anyị atụlee ihe isophane na harling, nke abụọ na-eme nwayọ karịa, na-enweghị ọnụ. Ọgwụ ngwa ngwa nke ọgwụ na-eme ka o kwe omume iji ya otu ugboro n'ụbọchị.

Dika ogo ejikọtara ndị na - anabata insulin, harling na insulin mmadụ nọ nso, yabụ, ndị ọrịa na-anabata ọgwụ ịgba ọgwụ nke ọma ma nye nsonaazụ ha chọrọ. A na-ahụta ọgwụ kwụsiri ike ka ụbọchị 2-4 gachara site na ntụtụ mbụ ya na nchịkwa ụbọchị. Ndị ọrịa na-enwe mmetụta mmalite nke ọgwụgwọ ọgwụgwọ 60 nkeji oge ogbugba ahụ, usoro ọgwụgwọ ahụ dị 24 awa 24-29. Mgbe o banye n’ime ahụ, Lantus, dịka ụmụ agbọghọ niile na-eme iberibe, ọ na-apụ na mmamịrị na akwara.

Dị Mkpa! Jiri pen sirinji dị ka nke onye nrụpụta siri kọwaa. Ọ dị mkpa ịgbanye insulin subcutaneously n'ime afọ, ukwu ụkwụ (apata), ubu.

Ihe ngosi na contraindications

Insulin tinyere aka na usoro glucose, ma ụkọ ya na - eme ka ịba ụba shuga n'ọbara, mee ka ahụike gị. A na-eji Solostar agwọ ụdị ọrịa na-adabere na insulin nke enwere ụkọ homonụ. Logydị ọrịa a na - etolite n'ihi ezughi oke ọria n'ihi ọrịa afọ ma ọ bụ enwetara. Solotar nwere ndakọrịta na ọgwụ ndị ọzọ nwere insulin. N'okwu a, ọ dị mkpa iji gbakọọ usoro dịgasị iche, họrọ ya na-eburu n'uche ọdịiche dị na oge ịme ihe. A na-eji ọgwụgwọ agwakọta agwọ ọrịa ụdị ndị ọrịa mamịrị 2.

Ihe mgbochi nye ojiji nke Harling bu:

• nfụkasị ahụ maka ihe ndị dị n'ọgwụ ahụ na ihe ahụ nọ n'ọrụ,
• nnukwu nsogbu gbasara akwara,
• afọ nwata ahụ erughị afọ 2.

Di na nkenke nke di ime bu ime ime. Womenmụ nwanyị dị ime kwesịrị ịgbanye insulin n'okpuru nchịkwa ọkwa shuga n'ọbara. N’oge ime ime ọ bụla, a chọrọ imeghari nanị otu ugboro ugboro abụọ, ya mere, dọkịta kwesịrị ilekọta ọgwụ insulin.

Nsonaazụ

Dabere na usoro ọgwụgwọ a tụrụ aro ya, mmeghachi ahụ anụ ahụ achọghị. Ma insulin ogologo oge nwere ike bute “otu mmetụta”.Ọtụtụ mgbe, nke a bụ mbelata shuga dị elu, nke na-egosipụta onwe ya:

• adịghị ike
• nsụhọ
• imebi usoro akwara ozi,
• ịkụda mmụọ
• Aka na ụkwụ,
• ọrịa shuga,
• obi ike.

Site na iwetulata glucose dị n’okpuru karịa ọkwa, hypoglycemic coma nwere ike ịmalite, nke bụ ọnọdụ dị oke mkpa chọrọ nlekọta ahụike mberede. Na mgbakwunye, ndị na-arịa ọrịa shuga nwere ike ịnweta mpaghara necrotic na saịtị nke injero ugboro ugboro, ya mere a ga-agbanwe mpaghara ntụtụ. Ọ bụrụ na agbasaghị ịdị ọcha, saịtị ịgba ọgwụ nwere ike ibute oria, na-akpata mbelata, itching na fluslus. A na-anwale ndị ọrịa na-eme ihe nfụkasị ma ọ bụ nwee ọrịa angioedema ụjọ maka nnabata insulin. Maka nke a, a na-enyocha intradermal ma na-enyocha mmeghachi omume nke anụ ahụ. Ọ bụrụ na enweghị ngosipụta na-adịghị mma, gaa n'ihu na ịgwọ ọrịa insulin.

Usoro onunu ogwu na ịdoụbiga mmanya ókè

E gosipụtara Lantus maka ịgwọ ọrịa shuga na ndị okenye, ndị na-eto eto na ụmụaka site na afọ 2. Ọ bụrụ na achọrọ ọgwụ insulin maka nwatakịrị na-erubeghị afọ abụọ, mgbe ahụ, a na-ekpebi dose ahụ na-ekpebi n’otu n’otu ma gbakọọ na-adabere n’arụ nwa ahụ. Onye mepụtara ọgwụ ahụ na ntuziaka a na-egosi n’ụzọ doro anya etu aga-esi enye ọgwụ a. A na-abanye insulin n'ime ndị okenye na ụmụaka n'ụdị otu ugboro n'ụbọchị, n'agbanyeghị oge ụbọchị, mana n'otu oge ahụ. Usoro nke ọgwụ a ga-agbakọ n'otu n'otu.

Na ụdị ọrịa shuga abụọ nke mellitus, Solostar na-arụ ọrụ dị ka otu ọgwụ, yana akụkụ nke ọgwụgwọ otu. Ikwesiri ịhazigharị ọgwụ mgbe ị na-agbanwe site na otu ụdị insulin gaa na nke ọzọ, yana ịba ụba ahụ, na-agbanwe usoro nke injections. Ihe ndị a na-emetụta nsonaazụ nke ọgwụ ahụ, ya mere, chọrọ mgbako ọhụrụ. Tupu iji pen-sirinji, dọkịta ahụ kọwaara onye ọrịa ahụ ka esi abanye, tinye agịga, ma họrọ ebe kwesịrị ekwesị maka ịgba ntụtụ. Nghazi ahụ achọghị nkà pụrụ iche, n'ihi na sirinji nwere agịga dị nkọ ma a na-eme ntụtụ ahụ n’enweghị mbọ ọ bụla. Enwere usoro nke usoro - onye ọrịa mamịrị ga-amụta iji aka ya kpebie n ’usoro ọ dị mkpa maka nchịkwa.

Dị Mkpa! Iji wepu ọrịa na ebe ntụtụ, jiri agịga otu oge. Mgbe ịgba agba nke mbụ gachara, a na-echekwa pen ahụ n’ebe gbara ọchịchịrị n ’ụlọ okpomọkụ ma were ihe karịrị ọnwa 1.

Ọ bụrụ na onye ọrịa ahụ emeela agadi ma ọ bụ na-arịa ọrịa ike nke akụrụ, yana mgbe ọ na-agbanwe insulin na-ajụ ma ọ bụ dị mfe na Solestar, a na-enye obere garglin obere. Naanị dọkịta nwere ike ịgbakọ nke a. Ọtụtụ mgbe, "Lantus" ka a na-edenye na ọnụọgụ 40-60% nke ọgwụ enyere emeburu. Edepụtara ọgwụ erughị ọgwụ maka ndị ọrịa na-a pụ ọgwụ nwere mmetụta hypoglycemic.

Dodoụbiga ọgwụ ókè bụ n'ihi nke a:

• nchịkwa ezighi ezi nke ịbawanye ụba,
• na-ezighi ezi usoro mgbako
• mgbanwe na saịtị ịgba ahụ,
• eji ụdị insulin ọzọ.

N'okwu a, onye ọrịa na-etolite hypoglycemia site na foto kwekọrọ na ya. Ọgwụgwọ bụ ihe mberede, symptomatic.

Mmekorita

Site na ntinye aka nke Lantus na ọgwụ site na otu ndị ọzọ na-emepụta ọgwụ, a na-achọpụta mgbanwe oge ogologo ọrụ insulin. Medicationsfọdụ ọgwụ nwere ike ịkwalite ọrụ insulin, ebe ndị ọzọ nwere ike belata mmetụta ọgwụgwọ. A na-ahụ mmụba na hypoglycemic mmetụta na mmekọrịta nke harling na:

• Ndị na - egbochi ACE, MAO,
• nhazi nke salicylic acid
• ndị ọrụ sulfnilamide
• ọgwụ ọgwụ hypoglycemic ọgwụ.

Ihe insulin na-ebelata bụ ndị:

• mmanya
• na-a medicationsụ ọgwụ nwere homonụ thyroid,
• diuretics
• ọgwụ steroid
• ọgwụ psychotropic.

Mgbe ị na-edepụta harlin insulin, ịkwesịrị ịchọpụta ọgwụ ndị ọzọ onye ọrịa na-ewere iji gbakọọ ọnụọgụ ziri ezi.

Ihe ntinye ma obu okwu nmechi maka Lantus Solostar nwere udi aru, ma ha di iche na usoro inyeaka.

Tebụl ahụ na-enye ndepụta nke analogues nke ọgwụ.

Ntughari Lantus ohuru bu Tujeo Solostar O nweghi ike ime ka anyi nwee “side side”, iji wee nweta ihe ogugu a choro, achoro okpukpu 3 pere mpe karia Lantus. A na-ewepụta ọgwụ ahụ na mkpịsị sirinji. N'elu ihe edere, e nwere ihe odide 300ED na ntọala mmanụ a honeyụ. Foto:

Kedu nke analogues ga-adabara onye ọrịa, dọkịta kpebiri, na-eburu n'uche usoro ọgwụgwọ nke ọrịa ahụ na ọnọdụ onye ọrịa ahụ.

Ndị ọrịa, yana ndị dọkịta, na-ahapụ nzaghachi ha na Internetntanetị gbasara ọgwụ a.

Angelina, onye gbara afọ 37, endocrinologist. Lantus na Tugiero nwere otu ụdị ihe eji eme ihe, mana na nkwadebe, ha na-etinye uche ha ike. Tujeo nwere ihe ndi ozo n’etiti ndi oria shuga, ebe odi nkpa ka odi nkpa iji choo shuga.

Anna, dị afọ 32. Ejiri Lantus mee ihe, wee gbanwee na Tujeo. Ahụrụ m ya n'anya karịa, ọ nweghị "mmetụta dị n'akụkụ", shuga bụ ihe nkịtị.

Vladislav, onye gbara afọ 46. Anọ m na-arịa ọrịa shuga kemgbe afọ iri. Nke mbu, o gbara Basis Insulin, ma Lantus. Ugbu a agbanweela na Tujeo. Enwere m mmetụta dị mma, enweghị mmeghachi omume na-adịghị mma, mana echefughị ​​m ihe oriri.

Ọnụ ego nke "Lantus" na ụlọ ahịa ọgwụ na Russia dịgasị na 2900 ruo 3200 rubles kwa ngwugwu.