Movoglen® (Movogleken)

Tọọ iche iche dabere na onyonyo onyonyo nke oria. Mkpụrụ mbụ nke Movoglechen bụ 2.5-5 mg 1 oge / ụbọchị 15-30 nkeji tupu nri ụtụtụ. Ọ bụrụ na ọ dị mkpa, enwere ike iji nwayọ were nwayọ (ya na obere oge) gbadaa site na 2.5-5 mg / ụbọchị. Shouldbọchị ọ bụla kariri 15 mg kwesịrị ka ekee ya abụọ.

Ogwu kachasị nke Movoglechen: otu - 15 mg, kwa ụbọchị - 40 mg.

Omume ọgwụ

Ngwunye ọgwụ hypoglycemic nke na-ahụ maka ọnya, ihe dị na usoro nke usoro nke n'ọgbọ nke abụọ. Na-akpali mmiri ọgwụ insulin site na sel-nke pancreas, na-abawanye ntọhapụ nke insulin. Ọ na-eme ka ahụrịị anụ ahụ dị elu na insulin. Ọ nwere hypoliplera, mmetụta fibrinolytic, na-egbochi nchịkọta platelet.

Nsonaazụ

Site na usoro endocrine: adịkarịghị - hypoglycemia (karịsịa na ndị agadi, ndị ọrịa na-esighi ike, na-eri nri oge na-adịghị mma, na-a alcoholụ mmanya, imeju na-arụ ọrụ na akụrụ).

Site na usoro digestive: ọgbụgbọ, afọ ọsịsa, ụkọ pụrụ iche - ịba ọcha n'anya.

Site na sistemu hemopoietic: n'ụfọdụ ọnọdụ - thrombocytopenia, leukopenia, agranulocytosis.

Mmeghachi omume nfụkasị: ọ na - adịkarịghị - ọnya anụ ahụ, itching.

Ntụziaka pụrụ iche

Mgbe ị na-eji Movoglechen mgbe insulin ma ọ bụ ihe ndị ọzọ hypoglycemic, a ga-atụle ngwa ngwa oriri Movoglechen n'ime ọbara yana na ụbọchị 4-5 mbụ a ga-achịkwa ọgwụ ahụ dịka profaịlụ glycemic si dị.

Site na mmepe nke hypoglycemia, ọ bụrụ na onye ọrịa maara, a na-edenye glucose (ma ọ bụ ihe ngwọta shuga) n'ime. Ọ bụrụ na mmụọ amaghị, a na-edozi glucose intravenous ma ọ bụ glucagon sc, intramuscularly ma ọ bụ intraven. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere carbohydrates iji zere ịmaliteghachi hypoglycemia.

Site na mmerụ ahụ, ọnya na-efe efe, nnukwu ịwa ahụ, a ga-ebufere onye ọrịa ahụ ka ọ jiri insulin.

Mmekorita

Ekwesighi iji Movoglechen mee ihe n'otu oge na miconazole.

Iji otu oge eji salicylates, sulfonamides, ndị na-egbochi ACE, ị alcoholụbiga mmanya ókè, mmeghachi omume hypoglycemic nwere ike ịmalite. Ojiji nke beta-egbochi nwere ike kpuchie ngosipụta nke hypoglycemia.

Thiazide diuretics, progestins sịntetik, GCS (gụnyere ngwa ọrụ), chlorpromazine na-akụda mmụọ nke Movoglechen.

Ndị na-ahụ maka ọgwụ

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Asambodo nnabata Movogleken ®

• LP-001191

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

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Mgbe ị na-ehota ihe ọmụma dị na peeji nke www.rlsnet.ru, njikọta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Ngwakọta Movoglechen n'ụdị mbadamba

Arụ Ọrụ: glipizide - 5 mg,

ndị mbụ: lactose 130 mg, pregelatinized stachi 30 mg, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0.8 mg, stearic acid 1.6 mg.

Mpempe cylindrical gburugburu nke agba ọcha na ihe osise "U" na okirikiri dị n'otu akụkụ na ihe ize ndụ n'akụkụ nke ọzọ.

Pharmacodynamics nke ọgwụ

Glipizide nwere mmetụta ọria akwara na extrapancreatic. Ọ na - eme ka mmiri ọgwụ insulin dị ala site na iwetulata ọnụma glucose anụ ahụ beta-cell na - ewe iwe, na - eme ka insulin na - ejikọta ya na mkpụrụ ndụ na - ezu ike, na - eme ka mwepụta insulin, kwalite ọrụ insulin na akwara na umeji glucose na - egbochi lipolysis na adipose anụ ahụ. Ogo nke mmetụta hypoglycemic dị na ọnụ ọgụgụ nke mkpụrụ ndụ beta na-arụ ọrụ. O nwekwara hypoliplera, mmetụta fibrinolytic, na-egbochi nchịkọta platelet, ma nwee mmetụta diuretic dị nro.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, glusizide na-agbakarị ngwa ngwa, ọ fọkwara nke nta ka etinye uche gị na akụkụ eriri afọ mmadụ. A na-enweta ntinye uche kachasị na plasma 1-3 awa mgbe ị aụchara otu. Iri nri anaghị emetụta mkpokọta na mkpokọta ọgwụ, otu oge, nnabata ahụ na-abawanye site na nkeji iri anọ. Bioavailability bụ 90%, ihe jikọrọ ya na protein protein bụ 98-99%.

Ọ bụ metabolized n'ime imeju na-adịghị metabolites-adịghị arụ ọrụ. Ọ bụ ya bụ akụrụ - 90% n'ụdị metabolites, 10 % - agbanweghi agbanwe.

Ọkara ọkara bụ awa 2-4.

Contraindications Movoglechen na ụdị mbadamba

hypersensitivity na sulfonylureas, sulfonamides,

hypersensitivity na glipizide ma ọ bụ ihe ọ bụla ọzọ nke ọgwụ ahụ,

ụdị shuga 1

ọrịa mamịrị ketoacidosis, precca mamịrị shuga,

ọnọdụ chọrọ insulin ọgwụ (oke ọkụ, nnukwu ịwa ahụ, nnukwu mmerụ ahụ na ọrịa na-efe efe),

ọrịa imeju na-arụ ọrụ nke ukwuu,

ụkọ lactase, nnagide nri nke lactose, glucose-galactose malabsorption,

ime, lactation.

Usoro onunu ogwu na uzo Movoglechen na udi ihe eji eme ya

Ọgwụ a na-adabere na afọ, ogo nke ọrịa shuga, ịba ụba nke glucose n'ọbara na afọ efu na awa 2 mgbe iri nri.

Kenye n'ime, nkeji iri atọ tupu nri. Ọgwụ mbụ kwa ụbọchị bụ 5 mg tupu nri ụtụtụ, ma ọ bụrụ na enweghị nsonaazụ, a na-abawanye dose ahụ site na 2.5-5 mg site na nlele mgbe niile nke ịbara glucose ọbara.

Na ọrịa nke imeju, akụrụ na ndị ọrịa agadi, ọgwụ mbụ kwa ụbọchị bụ 2.5 mg.

Igo ole ị dị bụ 15 mg, ọgwụ kachasị ụbọchị bụ 40 mg. Oge nchịkwa bụ oge 1 kwa ụbọchị, a ga-ekewa usoro ọgwụ kwa ụbọchị karịa 15mgg4 na usoro onunu ogwu.

Nsonaazụ ọgwụ

Site na usoro endocrine: hypoglycemia, hypoglycemic coma.

Si ụjọ usoro: dizziness, isi ọwụwa, iro ụra.

Na akpukpo ahu: ọnya na akpukpo aru mucous, akpụkpọ itching, urticaria, eczema, photosensitivity.

Site na akụkụ ahụ dị na hemopoietic: mgbochi nke ụmị ọbara ọbara (anaemia, gụnyere aplastic na hemolytic, pancytopenia, leukopenia, agranulocytosis, thrombocytopenia).

Site na nri digestive: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa ma ọ bụ afọ ntachi, flatulence, cholestatic jaundice, ọdịda imeju, ịba ọcha n'anya, oke porphyria, ọrịa ịba ọcha n'anya.

Si uche: ọhụhụ ụzọ.

Nnyocha ụlọ nyocha: mmụba nke aspartate aminotransferase (ACT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), mụbara urea nitrogen na plasma ọbara, hypercreatininemia.

Ndị ọzọ: Ibu ibu, myalgia, Mgbu, hyponatremia, disulfiram-like reaction.

Site na eriri afọ: ọgbụgbọ, ọgbụgbọ, afọ ntachi, afọ ọsịsa, mgbu azụ, ịba ọcha n'anya.

Na akpukpo ahu: urticaria friji, akpụkpọ itching, erythema multiforme exudative.

Site na akụkụ ahụ dị na hemopoietic: anaemia, aplastic na hemolytic anaemia, pancytopenia, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia.

Ndị ọzọ: Ikekwe mmepe nke hyponatremia na nsogbu nzuzo nke homonụ antidiuretic.

Dodoụbiga ya ókè

Doụbiga ọgwụ ike ókè nwere ike iduga mmepe nke hypoglycemia.

Mgbaàmà nke hypoglycemia: agụụ, ịba ụba ọsụsọ, adịghị ike dị ukwuu, ịma jijiji, nchekasị, isi ọwụwa, ehighị ụra nke ọma, ahụ erughị ala, ịda mbà n'obi, ikwu okwu na ọhụụ, itinye uche n'ihe na-adịghị mma, mmụọ na - adịghị mma, hypoglycemic coma.

Ọgwụgwọ: ọ bụrụ na onye ọrịa maara, were glucose ma ọ bụ shuga n'ime ime, ma ọ bụrụ na mmụọ amaghị ya, nchịkwa akwara dị mkpa 40 % dextrose ngwọta (glucose), mgbe ahụ - infusion nke 5% dextrose solution, 1-2 mg nke glucagon subcutaneously, intramuscularly ma ọ bụ intravenously. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere nnukwu carbohydrates na-adị ngwa ngwa (iji zere ịmalite ịmalite hypoglycemia). Na ọrịa ụbụrụ, mannitol na dexamethasone.

Leasedị mwepụta, nkwakọ ngwaahịa na ihe mejupụtara

Mbadamba cylindrical gburugburu na-acha ọcha nwere ihe osise "U" na okirikiri dị n'otu akụkụ na ihe ize ndụ n'akụkụ nke ọzọ.

Ndị pụrụ iche: lactose 130 mg, pregelatinized stachi 30 mg, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0.8 mg, stearic acid 1.6 mg.

24 PC. - blisters emere nke PVC / aluminom foil (2) - ngwugwu nke kaadiboodu.

Usoro usoro onunu ogwu

Tọọ iche iche dabere na onyonyo onyonyo nke oria. Usoro ọgwụgwọ mbụ bụ 2.5-5 mg 1 oge / ụbọchị 15-30 nkeji tupu nri ụtụtụ. Ọ bụrụ na ọ dị mkpa, enwere ike iji nwayọ were nwayọ (ya na obere oge) gbadaa site na 2.5-5 mg / ụbọchị. Shouldbọchị ọ bụla kariri 15 mg kwesịrị ka ekee ya abụọ.

Ogwu kachasị: otu - 15 mg, kwa ụbọchị - 40 mg.

Mmetụta akụkụ

Site na usoro endocrine: adịkarịghị - hypoglycemia (karịsịa na ndị agadi, ndị ọrịa na-esighi ike, na-eri nri oge na-adịghị mma, na-a alcoholụ mmanya, imeju na-arụ ọrụ na akụrụ).

Site na usoro digestive: ọgbụgbọ, afọ ọsịsa, ụkọ pụrụ iche - ịba ọcha n'anya.

Site na sistemu hemopoietic: n'ụfọdụ ọnọdụ - thrombocytopenia, leukopenia, agranulocytosis.

Mmeghachi omume nfụkasị: ọ na - adịkarịghị - ọnya anụ ahụ, itching.

Isi: isi ọwụwa.

Mkparịta ụka ọgwụ ọjọọ

Iji otu oge eji salicylates, sulfonamides, ndị na-egbochi ACE, ị alcoholụbiga mmanya ókè, mmeghachi omume hypoglycemic nwere ike ịmalite. Ojiji nke beta-egbochi nwere ike kpuchie ngosipụta nke hypoglycemia.

Thiazide diuretics, progestins sịntetik, GCS (gụnyere ngwa ọrụ), chlorpromazine na-ebelata ike nke glipizide.

Yiri ọgwụ:

• Guarem (Guarem) microseads nje
• Mbadamba amaryl
• Ngwọta Viktoza (Victoza) maka ịgba ntụtụ
• Metformin hydrochloride (Metformin hydrochlor> Nri-Powder
• Mpempe akwụkwọ nke Metformin-Teva (Metformin-Teva)
• Mpempe mkpụrụ okwu Galvus Met (Galvus Met)
• Mbadamba ụrọ Januvia
• Berlithion (Berlithion) Mbadamba ụbụrụ
• Mbadamba ụrọ nke glucovans (Glucovance)
• Mbadamba ụbụrụ Langerin (Lanagerin)

** Ntuziaka ọgwụgwọ bụ maka ebumnuche ọhụụ. Maka ozi ndị ọzọ, biko rụtụ aka na nkọwapụta onye nrụpụta. Ejila onwe gi ogwu, tupu ịmalite iji ogwu Movogleken ikwesiri ikwuru dọkịta. EUROLAB abụghị onye na-ata ahụhụ nsonaazụ ya site na iji ozi ezigara na portal. Ozi ọ bụla dị na saịtị a anaghị agbanwe ndụmọdụ nke dọkịta ma ọ nweghị ike ịbụ nkwa maka mmetụta dị mma nke ọgwụ ahụ.

Interested nwere mmasị na Movoglecen? Want chọrọ ịmatakwu nkọwa zuru ezu ma ọ bụ ịchọrọ ịhụ dọkịta? Ka ịchọrọ nyocha? Nwere ike gi na dọkịta gharia - Euro ọgwụ ụlọ nyocha mgbe niile n’ozi gị! Ndị dọkịta kachasị mma ga-enyocha gị, nye ndụmọdụ, nye enyemaka dị mkpa ma mee nchoputa. I nwekwara ike kpọọ dọkịta n'ụlọ. Euro Clinic ụlọ nyocha gheghe gi oghe.

** Ntị! Ihe omuma a gosiputara n’ime ndu ogwu a bu ndi okacha amara nke aru ike ya abughi ihe ndabere maka inyocha ogwu. Nkọwapụta ọgwụ Movoglecen bụ maka ozi naanị ebughi n'uche ịkọ ọgwụ na enweghị nnabata nke dọkịta. Ndị ọrịa chọrọ ndụmọdụ ọkachamara!

Ọ bụrụ na ị ka nwere mmasị na ọgwụ na ọgwụ ndị ọzọ, nkọwa ha na ntuziaka maka ojiji, ozi gbasara ihe mejupụtara na ụdị ntọhapụ, ihe ngosi maka ojiji na nsonaazụ, ụzọ ojiji, ọnụahịa na nyocha nke ọgwụ, ma ọ bụ nwere nke ọ bụla ajụjụ ndị ọzọ na ntinye - dee anyị akwụkwọ, anyị ga-anwa inyere gị aka.

Ojiji nke Movoglechen n'oge ime na inye nri

Usoro FDA maka ime nwa ebu n’afọ bụ C.

N'ihe eji eme n'oge afọ ime, ịkagbu bụ iwu 1 ọnwa tupu amụọ nwa na ntughari na usoro insulin.

N'oge ọgwụgwọ kwesịrị ịkwụsị inye ara.

Ọgwụ: ịwepụ ọgwụ, nnweta glucose na / ma ọ bụ mgbanwe nri na iji nlezianya nyocha nke glycemia, na nnukwu hypoglycemia (coma, ihe ọdịdọ) - ụlọ ọgwụ ozugbo, nchịkwa nke 50% mgbochi glucose na-agwọ ọrịa na ngwakọta nke imekotaotu oge (iv drip) 10 Ngwọta gluu% iji hụ na ịchebe glucose ọbara karịa 5.5 mmol / L, nlekota glycemia dị mkpa ruo ụbọchị 1-2 mgbe onye ọrịa ahụ hapụsịrị. Dialysis adighi ike.

Ralnweta mineral, glucocorticoids, amphetamines, anticonvulsants (ọgwụ hydantoin), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, ọgwụ mgbochi, epinephrine, ethacinic acid, giurimmeme, thymo gland, triamteren na ọgwụ ndị ọzọ na - ebute hyperglycemia. Anabolic steroid na androgens na-eme ka ọrụ hypoglycemic dịkwuo elu. Nlekọta anticoagulants na-apụtaghị ìhè, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin na-eme ka mkpokọta nke irighiri irighiri ọbara dị n'ọbara (n'ihi nchụpụ pụọ na protein plasma) ma mee ngwa ngwa biotransformation. Ketonazole, miconazole, ngọngọ sulfinpyrazone na-abawanye ma bulie hypoglycemia. Na ị Againstụbiga mmanya ókè, mmepe nke ọrịa disulfiram dịka ọrịa afọ, afọ mgbu, ọgbụgbọ, isi ọwụwa) ga - ekwe omume. Ọgwụ Antithyroid na ọgwụ myelotoxic na-eme ka ohere nke ịmalite ịrịa agranulocytosis, nke ikpeazụ, na mgbakwunye - thrombocytopenia.

Maka ụdị ngwa ngwa glitizide:

Site na sistemụ ụjọ na akụkụ ahụ: sensọ, isi ọwụwa, ehighị ụra nke ọma, ụra, nchekasị, ịda mba, ọgba aghara, ọgba aghara, paresthesia, hypersthesia, veil n'ihu anya, ihe mgbu anya, conjunctivitis, hemorrhage retinal.

Site n'akụkụ nke sisitemu obi yana ọbara (hematopoiesis, hemostasis): syncope, arrhythmia, ọbara mgbali elu, nnwere onwe nke ọkụ ọkụ.

Site n'akụkụ nke metabolism: hypoglycemia.

Site na ngwe nri: anorexia, ọgbụgbọ, ọgbụgbọ, mmetụta nke oke na mpaghara epigastric, dyspepsia, afọ ntachi, ọbara na-atọ ụtọ n'ime oche.

Site na anụ ahụ: ihe ọkụ ọkụ, urticaria, itching.

Site na usoro iku ume: rhinitis, pharyngitis, dyspnea.

Site na usoro mkpụrụ ndụ: dysuria, mbelata libido.

Ndị ọzọ: akpịrị ịkpọ nkụ, ịma jijiji, ụsọ akụkụ, ihe mgbu na - abụghị mpaghara niile, arthralgia, myalgia, cramps, sweating.

Maka ụdị ngwa ngwa glitizide:

Site na usoro ụjọ na akwara anụ ahụ: isi ọwụwa, dizziness, iro ụra.

Site na sisitemu obi na obara (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic ma obu aponstic anaemia).

Site n'akụkụ nke metabolism: ọrịa shuga insipidus, hyponatremia, ọrịa porphyrin.

Site na ngwe nri: ọgbụgbọ, ọgbụgbọ, ihe mgbu na mpaghara epigastric, afọ ntachi, ịba ọcha n'anya (ọnya na-acha odo odo na ọnya na-efe efe, na -anọ ọnya na ọchịchịrị mmamịrị, mgbu na hypochondrium dị mma).

Site na anụ ahụ: erythema, maculopapular rashes, urticaria, photoensitivity.

Ndị ọzọ: ịba ụba nke LDH, alkaline phosphatase, bilirubin na-apụtaghị ìhè.

Ọrịa nke digestive tract, imeju na akụrụ (chọrọ nlekọta mgbe niile maka ọkwa glucose ọbara), afọ ụmụaka (etinyere ịdị ike na nchekwa nke ụmụaka).

Hypersensitivity, ọrịa shuga, ketoacidosis, ọrịa shuga, ụdị ụmụaka 1 diabetes mellitus, fever, mmerụ ahụ, ihe ndị metụtara ịwa ahụ, ịtụrụ ime, inye nwa ara.

Elldị shuga abụọ nke ọrịa shuga na-enweghị mmetụta nke nri kalori, mmega ahụ zuru oke, wdg, microangiopathy mamịrị.

Mmetụta ọgwụ ahụ bụ hypoglycemic. Na-akpali mwepụta nke insulin site na mkpụrụ ndụ beta nke na-arụ ọrụ. Ọ na-ebelata ọkwa nke hemoglobin glycosylated na ịba ụba glucose na ndị ọrịa nwere ụdị ọrịa mellitus na-abụghị insulin na-agbadata. Na-ebelata hyperglycemia mgbe nri-nri gasịrị, na-eme ka ịnagide glucose na nhichapụ mmịpụta nke mmiri na-adịghị ala (na obere ntakịrị). Nzaghachi insulinotropic na-amalite n'ime minit 30 mgbe nchịkwa ọnụ gasịrị, oge iji mee ihe otu obere ruru awa 24. Ọ dịghị emetụta profaịlụ nke plasma ọbara.

N'ime nnwale na oke na ụmụ oke na nha 75 ugboro dị elu karịa MPD, ọ naghị ebute ọrịa carcinogenesis ma ghara emetụta ọmụmụ (oke). Ọmụmụ ihe emere na nje nje na vivo ekpugheghị akụrụngwa mutagenic.

Isdị ngwa ngwa na-abanye ngwa ngwa kpamkpam. Iri nri anaghị emetụta ngụkọta oge niile, mana ọ na-agbada ya ruo nkeji iri anọ. A na-ekpebi Cmax ka awa 1-3 gachara otu ọgwụ. T1 / 2 bụ awa 2-4. Mgbe ọ gbasịrị nwayọ nwayọ, ọ na-apụta n'ọbara mgbe awa 2-3 gachara, Cmax ruru mgbe awa 6-12. Ọ na - ejikọ protein protein plasma site na 98-99%. Olu nkesa mgbe nchịkwa iv bụ 11 l, nkezi T1 / 2 bụ awa 2-5 .. Mkpokọta nke Cl mgbe otu iv nchịkwa bụ 3 l / h. Biotrans gbanwee na imeju (ya na amaokwu nke mbụ - ntakịrị). Ihe na-erughi 10% na-agbanwegharị na mmamịrị na feces, ihe dị ka 90% dị n'ụdị metabolites na mmamịrị (80%) na feces (10%).

Ngwakọta ọcha na-acha ọcha. Insoluble na mmiri na mmanya, mana soluble na 0.1 mol / L NaOH na mmiri nke ukwuu na dimethylformamide.

N-2-4- (Cyclohexylamino) carbonylaminoum sulfonylphenylethyl-5-methylpyrazine carboxamide