Jardins: ntuziaka maka ojiji, analogues na nyocha, ọnụahịa na ụlọ ahịa ọgwụ nke Russia
Peeji a na-enye ndepụta niile nke Jardins analogues na usoro mejupụtara na ngosipụta maka ojiji. Ndepụta analogues dị ọnụ ala, ị nwekwara ike ịtụle ọnụ ahịa dị na ụlọ ahịa ọgwụ.
- Ndị Jardins dị ọnụ ala karịa:Forsyga
- Jardins ndị kachasị ewu ewu:Saxenda
- Nhazi ATX: Empagliflozin
- Ngwaọrụ mejupụtara / ihe mejupụtara: empagliflozin
| # | Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|---|
| 1 | Forsyga dapagliflozin Anọbara na ngosipụta na usoro eji | 12 nkp | 3200 UAH |
| 2 | Invokana canagliflozin Anọbara na ngosipụta na usoro eji | 13 nkp | 3200 UAH |
| 3 | Anwụ Satọde repaglinide Anọbara na ngosipụta na usoro eji | 30 nkp | 90 UAH |
| 4 | Ikwu eziokwu dulaglutide Anọbara na ngosipụta na usoro eji | 115 nkp | -- |
| 5 | Baeta igbapu Anọbara na ngosipụta na usoro eji | 150 ite | 4600 UAH |
Mgbe ị na-agbakọ ọnụ ego ahụ jardins dị oke ọnụ agbakwunyere ụgwọ opekata mpe enwere na ndepụta ọnụahịa nke ndị ahịa ọgwụ nyere
| # | Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|---|
| 1 | Saxenda liraglutide Anọbara na ngosipụta na usoro eji | 1374 rub | 13773 UAH |
| 2 | Ikwu eziokwu dulaglutide Anọbara na ngosipụta na usoro eji | 115 nkp | -- |
| 3 | Forsyga dapagliflozin Anọbara na ngosipụta na usoro eji | 12 nkp | 3200 UAH |
| 4 | Invokana canagliflozin Anọbara na ngosipụta na usoro eji | 13 nkp | 3200 UAH |
| 5 | Baeta igbapu Anọbara na ngosipụta na usoro eji | 150 ite | 4600 UAH |
Nyere ndepụta ọgwụ analogues dabere na ndekọ ọnụ ọgụgụ nke ọgwụ a kacha chọọ
Analogs site na ngosipụta na usoro eji
| Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|
| Lixumia lixisenatide | -- | 2498 UAH |
| Guarem Guar resin | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 nkp | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 ite | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 nkp | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 nkp | 3200 UAH |
| Invocana canagliflozin | 13 nkp | 3200 UAH |
| Dulaglutide Trulicity | 115 nkp | -- |
Ngwakọta dị iche iche, nwere ike yikọ ọnụ na njiri na usoro nke ngwa
| Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|
| Rosiglitazone enyere aka, metformin hydrochloride | -- | -- |
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 nkp | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metinin, Sibutramine | 20 nkp | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 nkp | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Hydrochloride Mpempe | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Formethine | 37 nkp | -- |
| Metformin Canon metformin, ovidone K 90, stachi ọka, crospovidone, magnesium stearate, talc | 26 nkp | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Metformin-teva metformin | 43 nkp | 22 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
| Glibenclamide Glibenclamide | 30 nkp | 7 UAH |
| Maninyl Glibenclamide | 54 nkp | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 nkp | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeton MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 nkp | 44 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 nkp | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Ọlta | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay Glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Glim | -- | -- |
| Glimepiride glimepiride | 27 nkp | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 ite | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Diamlaid glamepiride | 2 ite | -- |
| Micronized Amaryl M Limepiride, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 nkp | 101 UAH |
| Glucovans glibenclamide, metformin | 34 nkp | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 nkp | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 nkp | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 nkp | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Mee metformin XR mechie, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 ite | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 nkp | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 nkp | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 nkp | 895 UAH |
| Onglisa saxagliptin | 1472 nkp | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 nkp | 1434 UAH |
Etu esi achọta analog dị ọnụ ala nke ọgwụ na-akwụ ụgwọ?
Iji chọta analog na-enweghị ego ọfụma n’egwuregwu, mkpụrụ ọgụgụ ma ọ bụ ntụgharị, nke mbụ anyị na-atụ aro ị attentiona ntị na ihe mejupụtara ahụ, ya bụ otu ihe ahụ na njiri mara maka ojiji. Otu ihe eji eme ọgwụ eme ihe ga-egosi na ọgwụ ahụ kwekọrọ na ọgwụ ahụ, ọgwụ kwekọrọ ma ọ bụ ọgwụ ọzọ. Agbanyeghị, echefula maka ihe ndị na - adịghị ike nke ọgwụ ndị yiri ya, nke nwere ike imetụta nchekwa na ịdị irè. Echefula banyere ntuziaka nke ndị dọkịta, ọgwụ ịchọrọ onwe gị nwere ike imerụ ahụ ike gị, yabụ gbaa dọkịta gị mgbe niile tupu ị beforeụ ọgwụ ọ bụla.
Ntụziaka Jardins
INWETA Mpempe mwepụta Ngwakọta Mbukota Omume ọgwụ Jardins, ihe ngosi maka ojiji Ihe ngbanwe Kedu ihe na-enyere ndị Jardins aka? Dịka ntuziaka ahụ si dị, enyere ọgwụ a maka ọgwụgwọ nke ndị nwere ọrịa shuga 2:
n'iji ọgwụ eme ihe
JARDINS
mbadamba ihe mkpuchi
Otu mbadamba 1 nwere:
ihe na-arụ ọrụ: empagliflozin 10 na 25 mg
ndị na - ahụkarị: lactose monohydrate, celclose microcrystalline, hyprolose (hydroxypropyl cellulose), ssumum croscarmellose, silloon silicon dioxide, magnesium stearate.
Ngwakọta ihe nkiri: opadry edo edo (02B38190) (hypromellose 2910, titanium dioxide (E171), talc, macrogol 400, odo iron oxide odo (E172).
10 na 30 mbadamba.
Jardins - hibdị Inhibitor Type 3 Sodium glucose Transporter Inhibitor
2dị ọrịa shuga abụọ:
dị ka monotherapy na ndị ọrịa na-ezughị ezu nchịkwa glycemic naanị megide ndabere nke nri na mmega ahụ, nhọpụta nke metformin nke a na-ahụta adịghị mma n'ihi ntachi obi,
dị ka usoro njikọta na ndị ọrịa hypoglycemic ndị ọzọ, gụnyere insulin, mgbe ọgwụgwọ etinyere na njikọta na nri na mmega ahụ anaghị enye njikwa glycemic dị mkpa.
hypersensitivity na akụkụ ọ bụla nke ọgwụ,
ụdị shuga 1
ọrịa mamịrị ketoacidosis,
Ọrịa ndị a na - adịghị ahụkebe (ụkọ lactase, ekweghị anabata lactose, glucose-galactose malabsorption),
Ezinaụlọ gbasara akụrụngwa na GFR A na-egosi ozi niile maka ebumnuche gbasara ya, ọ bụghịkwa ihe kpatara onwe-ịkọ ma ọ bụ dochie ọgwụIhe ngosi maka ojiji
Ntụziaka maka iji Jardins (10 25 mg), usoro onunu ogwu
A na-ewere mbadamba okwu ọnụ 1 kwa ụbọchị, n'otu oge ahụ, jiri mmiri sachaa ya. Iji ọgwụ ọjọọ eme ihe ga-ekwe omume n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri oriri.
Usoro ọgwụgwọ akwadoro maka Jardins bụ 10 mg 1 oge kwa ụbọchị. Ọ bụrụ na ọ naghị enye njikwa glycemic zuru oke, mgbe ahụ usoro ọnụọgụ ọgwụ abawanyele karịa - 1 mbadamba Jardins 25 mg 1 oge kwa ụbọchị.
Ọ bụrụ n’ikpere otu ọgwụ, ị ga-a theụ ọgwụ ozugbo onye ọrịa chetara nke a. Ejila okpukpu abụọ n’ime otu ụbọchị.
Site na iji Jardins jikọtara ya na ihe ndị na-enye sulfonylurea ma ọ bụ ya na insulin, enwere ike ịbelata mbelata nke sulfonylurea / insulin n'ihi nsogbu nke hypoglycemia.
Ntụziaka pụrụ iche
Maka ndị ọrịa nwere nsogbu gbasara akụrụ na GFR site na 45 ruo 90 ml / min / 1.73 m2, ọ dịghị achọrọ ịme mgbanwe dose.
Ndị ọrịa nwere ọdịda akụrụngwa na GFR
Nyocha 3 maka “Jardins”
Jarins na-ewere otu afọ. Aro tụrụ si na 15 ruo 6-8. Ibu ibu dara kilogram 10. Ike ọgwụgwụ na ike ọgwụgwụ. N’oge na-adịbeghị anya, ọhụụ m dara na mberede. Yabụ - otu onye na-agwọ ọrịa, nke ọzọ nke nkwarụ.
Ogwu ahu di nma nke ukwuu, o nyeere nne m aka iwetulata shuga tupu aru oru ya, ndi dibia achoghi igba ogwu n'ihi nnukwu shuga, ndi jard na enyere anyi aka na nke a. Ugbu a, anyị anaghị anabata, mana shuga na-ejide nke ọma.
Nnukwu ogwu! Ana m akwado ndị na-enweghị ọganihu na ọgwụgwọ ga-enyere aka.
Usoro onunu ogwu:
mbadamba ihe mkpuchi
1 otu mbadamba ihe mkpuchi fim nwere:
Arụ Ọrụ:
empagliflozin - 10 mg / 25 mg,
Ndị e mere:
lactose monohydrate - 16.50 / 113.0 mg, microcrystalline cellulose - 62.50 / 50.0 mg, hyprolose (hydroxypropyl cellulose) - 7.5 / 6.0 mg, croscarmellose sodium - 5.0 / 4.0 mg, colloidal silicon dioxide - 1.25 / 1.0 mg, magnesium stearate - 1.25 / 1.0 mg,
Shei:
Opadry edo edo (02B38190) - 7.0 / 6.0 mg (hypromellose 2910 - 3.5 / 3.0 mg, titanium dioxide (E 171) - 1.733 / 1.485 mg, talc - 1.4 / 1.2 mg, macrogol 400 - 0.35 / 0.3 mg, iron dye oxide edo edo (E 172) - 0.018 / 0.015 mg).
Nkọwa
10 mg mbadamba
Mpempe akwụkwọ okirikiri biconvex gbara ya gburugburu, kpuchie ya na fim nwere agba odo na-acha odo odo na ihe osise ụlọ ọrụ dị n'otu akụkụ nke mbadamba ya na “S10” n'akụkụ nke ọzọ.
Mbadamba 25 mg
Mbadamba ụrọ nke biconvex nke nwere agba gbara agba, kpuchie ya na mpempe ihe nkiri nke agba odo na-acha odo odo, nke e sere na akara ụlọ ọrụ dị n'otu akụkụ nke mbadamba ya na “S25” n'akụkụ nke ọzọ.
Ngwongwo ogwu
Mlọ ọgwụ
Empagliflozin bụ onye agbanweegharị, na-agbasi mbọ ike, na-ahọrọ ma na-asọ mpi nke onye na-ebuga ụdị glucose abụọ sodium na ntinye uche chọrọ igbochi 50% nke ọrụ enzyme (IC50) nke 1.3 nmol. Nhọrọ nke empagliflozin ji okpukpu puku ise dị elu karịa n ’ụdị onye na-ebuga glucose n'ụdị 1 sodium na-ahụ maka nnabata nke glucose na eriri afọ. Na mgbakwunye, achọpụtara na empagliflozin nwere oke nhọrọ maka ndị na-ebuga glucose ndị ọzọ na-ahụ maka glucose homeostasis n'ụdị anụ ahụ dị iche iche.
Thedị sodium na-ebugharị ụdị glucose dị mkpa bụ protein protein na-ebu maka nnabata nke glucose site na renal glomeruli azụ banye n'ọbara. Empagliflozin na-emezi nchịkwa glycemic na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa mellitus (T2DM) site na ibelata realsorption kelion. Ọbara glucose na-eto site na akụrụ jiri usoro a dabere na ntinye glucose na ọbara yana ọnụego mkpokọta ụwa (GFR). Mmachi nke ndị na-ebu sodium na-ebute ụdị glucose ụdị 2 n'ime ndị ọrịa nwere ụdị shuga 2 na hyperglycemia na-eduga na mkpocha glucose oke site na akụrụ.
N'ime ọmụmụ ụlọ ọgwụ, achọpụtara na na ndị ọrịa nwere ọrịa shuga 2, akụrụ na-enwewanye glucose ngwa ngwa mgbe ejiri ọgwụ mbụ nke empagliflozin, mmetụta a gara n'ihu ruo awa 24. Mmụba nke mgbatị glucose site na akụrụ gara n'ihu ruo mgbe ngwụsị nke oge izu 4, na empagliflozin na dose nke 25 mg otu ugboro kwa ụbọchị, na nkezi, ihe dịka 78 g / ụbọchị. N'ime ndị ọrịa nwere ụdị shuga nke 2, akụrụba mụbara site na akụrụ mere ka mbelata glucose plasma ozugbo.
Empagliflozin na -ebelata mkpokọ glucose na plasma ọbara ma n'okwu ọnụ na mgbe e risịrị nri.
Uzo oru a na - achoghi ka insulin na - eme ihe na - eme ka enwee nsogbu di ala banyere hypoglycemia nke puru ime.
Mmetụta nke empagliflozin adịghị adabere na ọnọdụ arụ ọrụ nke mkpụrụ ndụ beta nke pancreatic na metabolism metabolism. Ezi mmetụta nke empagliflozin na akara ndị nọchiri anya arụmọrụ beta, gụnyere ntụpọ HOMA-ß (ihe atụ maka inyocha homeostasis-B) na oke nke proinsulin na insulin. Na mgbakwunye, iwepụ glucose ọzọ site na akụrụ na-eme ka a ghara inwe calorie, nke na-esobelata olu nke anụ ahụ adipose na mbelata nke ahụ.
A na-ahụkarị Glucosuria n'oge eji empagliflozin yana ntakịrị mmụba na diuresis, nke nwere ike itinye aka na mbelata ọbara mgbali elu.
N'ime ule nke ụlọ ọgwụ ebe ejiri mee ihe empagliflozin dị ka monotherapy, ọgwụgwọ nkwonkwo na metformin, ọgwụgwọ ngwakọta na metformin na usoro sulfonylurea, ọgwụgwọ njikọta na metformin ma e jiri ya tụnyere glimepiride, ọgwụgwọ njikọta na pioglitazone +/- metformin, dịka ọgwụgwọ nkwonkwo na dipeptidyl peptide inhibitor 4 (DPP-4), metformin +/- ọgwụ ọgwụ hypoglycemic ọzọ, n'ụdị njikọta ọgwụ na insulin, ọ bụ ihe ndekọ ọnụ ọgụgụ buru ibu mbelata m nke ịba ọcha n'anya HbAlc na mbelata glucose plasma na-ebu ọnụ.
Ihe ngbanwe
- Hypersensitivity n'akụkụ ọ bụla nke ọgwụ ahụ,
- Ọrịa shuga 1dị 1
- Ọrịa mamịrị ketoacidosis
- Ọrịa ọgbụgba sitere oke oke (ụkọ lactase, ekweghị anabata lactose, glucose-galactose malabsorption),
- Oru ntaramahu n’ime GFR Jiri n’oge ime na n’oge a na-enye nwa ara
A na - egbochi ojiji nke empagliflozin n'oge afọ ime n'ihi data ezughi oke na arụmọrụ yana nchekwa.
Ihe omuma enwetara na omumu omumu banyere umu anumanu na egosi ezi nnabata nke empagliflozin n’ime mmiri ara. E wezuga ohere ịmụrụ nwa amụrụ ọhụrụ na ụmụaka n’oge a na-enye nwa ara. A na - egbochi contraagliflozin maka inye ara ara. Ọ bụrụ na ọ dị mkpa iji empagliflozin n'oge ara, a ga-akwụsị ịhapụ inye ya ara.
Usoro onunu ogwu na nhazi
Monotherapy ma ọ bụ ọgwụgwọ ngwakọta
Usoro akwadoro ịmalite bụ 10 mg (1 mbadamba ọgwụ nwere ọgwụ nke 10 mg) otu ugboro kwa ụbọchị, site na ọnụ.
Ọ bụrụ na ọgwụ kwa ụbọchị nke 10 mg anaghị enye njikwa glycemic zuru oke, enwere ike ịbawanye dose ahụ gaa 25 mg (1 mbadamba ọgwụ nwere usoro 25 mg otu ugboro n'ụbọchị). Oke kachasị kwa ụbọchị bụ 25 mg.
A pụrụ ị Jụ ọgwụ JARDINS n'agbanyeghị nri n'oge ọ bụla n'ụbọchị.
Omume ka ikagbu ị takingụ otu ọgwụ ma ọ bụ karịa
Mgbe ịwụsịrị ọgwụ, onye ọrịa ahụ kwesịrị ị takeụ ọgwụ ọgwụ ozugbo o chetara nke a.
Ejila okpukpu abụọ n’ime otu ụbọchị.
Ndị otu ọrịa pụrụ iche
Na mmezi nke akụrụngwa yana GFR site na 45 ruo 90 ml / min / 1.73 m2, ọ dịghị achọrọ ịmegharị dose.
Ndị ọrịa nwere ọdịda akụrụngwa na GFR erughị 45 ml / min / 1.73 m2 ka akwadoghị iji ọgwụ ahụ n'ihi enweghị ike.
Ọchọghị ndị ọrịa nwere nsogbu ọria imeju ha.
Dodoụbiga ya ókè
Ọrịa
N'oge ule a na-achịkwa, a na-anabatakwa otu ọgwụ emagliflozin 800 mg (ugboro 32 karịa kwa ụbọchị) na ndị ọrụ afọ ofufo ahụike na otutu doses na-eru 100 mg (ugboro anọ karịa kwa ụbọchị) na ndị ọrịa nwere ụdị shuga 2 na-anabata nke ọma. Mmụba a chọpụtara na oke mmamịrị emetụtaghị ntụtụ ọnwere ya na enweghị ọgwụgwọ. Enweghị ahụmịhe na dose karịrị 800 mg.
Ọgwụgwọ
N'ihe banyere ịdoụbiga mmanya ókè, a na-atụ aro ka ewepu ọgwụ ahụ a na-akabeghị aka na eriri afọ, a na-arụ ọrụ nlele na usoro ọgwụgwọ.
Mmekọrịta na ọgwụ ndị ọzọ
Na ntule mmekọrịta nyocha ọgwụ ọgwụ vitro
Empagliflozin anaghị egbochi, inactivate, ma ọ bụ kpalite CYP450 isoenzymes. Routezọ nke metabolism nke empagliflozin mmadụ bụ glucuronidation yana ntinye nke uridine-5′-diphospho-glucuronosyltransferases UGT2B7, UGT1A3, UGT1A8 na UGT1A9. Empagliflozin anaghị egbochi UGT1A1. Mkparịta ụka ọgwụ ọjọọ nke empagliflozin na ọgwụ ndị na-anọchi anya CYP450 na UGT1A1 isoenzymes bụ ihe a na-agaghị ele anya.
Empagliflozin bụ mkpụrụ maka glycoprotein P (P-gp) na protein cancer ara ure (BCRP). mana na ọgwụgwọ ogwu anaghị egbochi protein ndị a. Dabere na data sitere na ọmụmụ banyere vitro, ekwenyere na ike nke empagliflozin soro ndị ọgwụ na-eji glycoprotein P (P-gp) meekọrịta mmekọrịta. Empagliflozin bụ mkpụrụ maka ndị na - eburu ikuku anionic: OATZ, OATP1B1 na OATP1VZ, mana ọ bụghị ntụgharị maka ndị na - ebu ikuku anionic 1 (OAT1) na ndị na - ebu cationic 2 (OST2). Agbanyeghị, mmekọrịta mmadụ na ọgwụ nke empagliflozin ya na ọgwụ ndị na-edochi protein na ebu dị ka akọwara n’elu anaghị ele anya na-agaghị enwe isi.
Na ntule mmekọrịta mkparịta ụka nke vivo
Aclọ ọgwụ ọgwụ nke empagliflozin anaghị agbanwe agbanwe na ndị ọrụ afọ ofufo mara mma mgbe ejiri ya na metformin, glimepiride, pioglitazone, sitagliptin, linagliptin, warfarin, verapamil, ramipril, simvastatin, torasemide na hydrochlorothiazide. Combinedjikọtara ojiji nke empagliflozin na gemfibrozil, rifampicin na probenecid gosipụtara mmụba na AUC nke empagliflozin site na 59%, 35% na 53%, n'otu n'otu, mana echeghị mgbanwe ndị a dị ka ọgwụ.
Empagliflozin enweghị mmetụta dị egwu na ụlọ ọgwụ na ọgwụ ọgwụ nke metformin, glimepiride, pioglitazone, sitagliptin, linagliptin, warfarin. digoxin, ramipril, simvastatin, hydrochlorothiazide, torasemide na mgbochi igbo.
Diuretics
Empagliflozin nwere ike ịkwalite mmetụta diuretic nke thiazide na "loop", nke n'aka nke ya nwere ike ịbawanye n'ihe ize ndụ nke akpịrị ịkpọ nkụ na hypotension.
Insulin na ọgwụ nke na - eme ka ihe nzuzo ya dịkwuo elu
Insulin na ọgwụ na-eme ka ihe nzuzo ya dịkwuo elu, dị ka sulfonylureas, nwere ike ịbawanye ohere nke hypoglycemia. Ya mere, n'iji insagliflozin na-ejikọ ya na insulin na ọgwụ na-eme ka nzuzo ya dịkwuo elu, ọ nwere ike ịdị mkpa iji belata ọgwụ ha, iji zere ihe ize ndụ nke hypoglycemia.
Ntụziaka pụrụ iche
A naghị akwado ọgwụ ọgwụ JARDINS maka ndị ọrịa nwere ụdị ọrịa shuga 1 nke ọrịa mamịrị na maka ọgwụgwọ ketoacidosis nke ọrịa mamịrị.
Oke nke ụbọchị JARDINS nwere ọgwụ lactose 113, yabụ ekwesighi iji ọgwụ ahụ mee ihe na ndị ọrịa nwere ọrịa ha ketara eketa dị ka ụkọ lactase, enweghị ntachi obi, glucose-galactose malabsorption.
Ọmụmụ ihe omimi egosila na ịgwọ ya na nsogbu nke ọgwụ na ọgaghị ebute mmụba n'ihe gbasara obi. Ojiji nke empagliflozin na dose nke 25 mg adịghị eduga n'ịgbatịkwu oge etiti QT.
Site na iji njikọta ọgwụ JARDINS nwere ọgwụ sulfonylurea ma ọ bụ jiri insulin mee ihe, enwere ike ịbelata mbelata nke sulfonylurea / insulin n'ihi ohere nke hypoglycemia.
Achọghị njikọta ọgwụ hypoglycemic
A mutabeghị Empagliflozin yana mgbakwunye glucagon-like peptide 1 analogues (GLP-1).
Nyochaa akụrụ
Ofdị irè nke ọgwụ JARDINS na-arụ ọrụ nke akụrụ. Ya mere, a na-atụ aro ka nyochaa ọrụ akụrụngwa tupu oge a ga-eme ya ma oge site n'oge ọgwụgwọ (ọbụlagodi otu ugboro n'afọ), yana tupu agbapụta usoro ọgwụgwọ, nke nwere ike imetụta ọrụ akụrụ. Ndị ọrịa nwere ọdịda akụrụngwa (GFR erughị 45 mlmin). ị notụ ọgwụ adịghị akwadoro.
Ndị okenye na-arịa ọrịa
Ọrịa dị afọ iri asaa na ise ma ọ bụ karịa nwere ohere nke mmiri akpọnwụ akpọnwụ. N'ime ndị ọrịa dị otú a na-emeso empagliflozin, a na-ahụkarị mmeghachi omume na-adịghị mma nke hypovolemia (ma e jiri ya tụnyere ndị ọrịa na-anata placebo). Ahụmahụ empagliflozin na ndị ọrịa ihe karịrị afọ 85 dị obere, yabụ, anaghị atụ aro ka o nyefee ndị ọrịa n ’ọgwụ ọrịa JARDINS.
Jiri n'ime ndị ọrịa n'ihe ize ndụ nke ịmalite hypovolemia
Dika usoro eji eme ihe, ochichi nke ogwu JARDINS nwere ike ibute mgbali elu obara. Ya mere, ekwesiri iji ogwu mee ihe na nlezianya na ọnọdụ mmerụ ọbara na-adịghị mma, dịka ọmụmaatụ, na ndị ọrịa nwere ọrịa obi, ndị ọrịa na-a drugsụ ọgwụ antihypertensive (ya na akụkọ ihe mere eme nke hypotension), yana ndị ọrịa karịa afọ 75.
Na ihe omume na onye ọrịa na-a theụ ọgwụ JARDINS. ọnọdụ ndị nwere ike ibute ọrịa mmerụ (dịka ọmụmaatụ, yana ọrịa nke eriri afọ), a ga-enyocha ọnọdụ onye ọrịa, ọbara mgbali, yana hematocrit na nguzozi electrolyte. O nwere ike ịchọ nwa oge, iji weghachite nguzo mmiri, kwụsị ịkwụsị ọgwụ.
Ọrịa ọnya na-efe efe
Ọnọdụ nke mmetụta ndị dị ka ọrịa urinary na-emetụta ya na empagliflozin na dose nke 25 mg na placebo, yana nke kachasị elu na empagliflozin na 10 mg. A na-ahụkarị ọrịa ọnya urinary (dịka pyelonephritis na urosepsis) nwere oge yiri ya na ndị ọrịa na-ewere empagliflozin na placebo. N'ihe banyere ọrịa ọnya ọnya ụbụrụ na-esiri ike, ịhapụ ịkwụsị iji ọgwụ emagliflozin ga-adị nwa oge.
Ratorylọ nyocha Urinalysis
Dabere na usoro nke ime ihe na ndị ọrịa na-ewere ọgwụ JARDINS, a na-ekpebi glucose dị na mmamịrị.
Mmetụta ikike ịkwọ ụgbọala na usoro
Emebeghị nnyocha omumu ihe banyere nsogbu nke emagharilozin n’ikike igbapu ugbo ala na ihe ndi ozo. Ndị ọrịa kwesịrị ịkpachara anya mgbe ha na-anya ụgbọ ala na usoro, ebe ọ bụ na mgbe ị na-eji ọgwụ JARDINS (karịsịa yana njikọta na usoro sulfonylurea na / ma ọ bụ insulin), hypoglycemia nwere ike ịmalite.
Jardins Ihe Na-agbanwe Ndụ
NovoNorm (mbadamba) Rating: 163
Ihe analogue dị ọnụ ala site na 59 rubles.
NovoNorm bụ nhazi mbadamba si otu mpaghara ọgwụ, mana nwere ihe dị iche na-arụ ọrụ. A na-eji Repaglinide mee ihe ebe a na usoro onodu ogwu nke 0,5 ruo 2 mg. Ihe ngosi maka ideputa ihe yiri ihe a, mana contraindications di iche n'ihi DV di iche na mbadamba ihe, ya mere jiri nlezianya guo ntuziaka ma gwaa dọkịta gi.
Diagninide (mbadamba) Rating: 142
Diagninide bụ ihe nnọchi anya ndị Russia maka otu ọnụahịa nwere otu ọnụ ọgụgụ mbadamba kwa otu. Ngwakọta na usoro nke ihe ahụ na-arụ ọrụ si dị iche na Jardins, mana enyere ya maka ịgwọ ụdị ọrịa shuga nke 2 yana mmega ahụ na nri adịghị arụ ọrụ.
Ihe omuma banyere ogwu ahu, ihe mejuputara ya
Ejiri Jardins ọgwụ mee ihe iji chịkwaa ọbara shuga n'oge monotherapy. Na mgbakwunye, akụrụngwa a nwere ike iji dịka akụrụngwa n’oge ọgwụgwọ siri ike na ọgwụgwọ ọrịa shuga.
Enwere ike iji ngwaọrụ ahụ yana ọgwụ ọgwụ hypoglycemic ndị ọzọ. Medicinesdị ọgwụ ahụ nwere ike ịgụnye insulin ma ọ bụ metformin.
A na-ere ọgwụ na ahịa nke ọgwụ ọgwụ na nsụgharị abụọ dị iche na ọnụọgụ kemịkal na-arụ ọrụ.
Dabere na dose nke isi ihe dị n'ọrụ, otu mbadamba nkwadebe nwere ike ịnwe 10 ma ọ bụ 30 mg nke ihe ndị na-arụ ọrụ.
Na mgbakwunye na kọmpụta ọrụ bụ isi, a na-etinye ihe ndị a n'otu mbadamba ọgwụ:
- lactose monohydrate,
- microcrystalline cellulose,
- Hyprolose
- sodium croscarmellose,
- silica
- stereta magnesium.
Mbadamba ọgwụ a na-ete ọgwụ, nwere ihe ndị a:
- Opadra edo edo,
- hypromellose,
- titanium dioxide
- ntụ ntụ talcum
- macrogol 400,
- iron oxide di odo.
Mgbe ị na-a drugụ ọgwụ a, ekwesiri icheta nke ọma na ojiji nke Jardins iji mee ka ọkwa shuga dị n'ọbara nke onye ọrịa nwere ụdị shuga 2 enweghị ike ịzọpụta mmadụ n'ọrịa a.
Isi ihe dị na ọgwụ ọgwụ
A na-ejikarị ọgwụ ọgwụ Jardins mee ihe na nkà mmụta ọgwụ ọhụụ iji dozie shuga ọbara dị elu na onye nwere ọrịa shuga 2.
Nyocha nke ndị ọkachamara ọgwụ na-egosi na ngwá ọrụ a na-eme ka o kwe omume ịchịkwa ọdịnaya shuga n'ụzọ dị mma n'ahụ ahụ onye ọrịa ma rụpụta nsonaazụ kachasị mma.
Empagliflozin, ịbụ isi ọgwụ ọgwụ na-arụ ọrụ, bụ nhọrọ ahọghari, ma nwee ike ịgbanye oke na-asọmpi onye na-ebuga glucose pụrụ iche.
Ngwakọta a na - eme ka ikike ịchịkwa ọkwa shuga dị n’ahụ nke onye ọrịa nwere ụdị shuga 2. Nsonaazụ nke ihe dị n’ime ọgwụ ahụ bụ na ọ na - enyere aka belata ọkwa glucose reabsorption n’usoro nke akụrụ. Mgbe ị na-a theụ ọgwụ, shuga dị na mmamịrị na-abawanye, nke na-enyere aka iwepụ glucose dị ukwuu n’ahụ.
Ojiji nke ọgwụ a anaghị emetụta ọrụ nke mkpụrụ ndụ beta. Akụrụngwa na-arụ ọrụ nwere mmetụta bara uru na anụ ahụ, ọ na-enyere aka melite ọrụ ya.
Mmeghe nke empagliflozin n'ime ahụ na-emetụta usoro nke abụba ọkụ ma na-enyere aka belata ibu nke onye ọrịa nwere ụdị shuga 2. Nsonaazụ ndị ọzọ site na iji ọgwụ a dị ezigbo mkpa maka ndị buru oke ibu na-arịa ụdị ọrịa shuga 2.
Ọkara ndụ nke ọgwụ na-arụ ọrụ na-arụ ọrụ ruo awa iri na abụọ. Ọgwụ kwụsịrị n’ahụ nke ihe na-arụ ọrụ nke nwere otu ọgwụ kwa ụbọchị na-enweta mgbe ị fifthụsịrị usoro nke ise nke ọgwụ ahụ.
Site na ahụ mmadụ, ihe ruru pacenti iri isii na ọgwụ ọgwụ a isụsịrị dị na ya. A na-eme ka mgbatị metabolites jiri eriri afọ na akụrụ. Site na eriri afọ, a na-eweghachi ogige nọ n'ọrụ agbanwebeghị. Mgbe ewepụtara akụrụ, naanị 50% nke ihe ndị mejupụtara ọgwụ ahụ adịghị apụ apụ.
Theta ụta nke arụ ọrụ n’ahụ niile na-emetụta nke ukwuu site na ọnụnọ n’ime onye ọrịa nwere nsogbu gbasara akụrụ ma ọ bụ ọrụ ịba ọcha n’anya.
Oke ahụ mmadụ, okike na afọ anaghị emetụta ọgwụ ọgwụ aka ike nke ọgwụ na-arụ ọrụ.
Ntuziaka maka iji ọgwụ ahụ
A na-eji ọgwụ ahụ eme ihe maka mono - ma ọ bụ ọgwụgwọ siri ike. Usoro a tụrụ aro bụ 10 mg - otu mbadamba kwa ụbọchị. Ejiri ọnụ na-aralụ ọgwụ ahụ.
Ọ bụrụ na kwa ụbọchị nke 10 mg enweghị ike ịnye nsonaazụ glycemic nkịtị, usoro ọgwụgwọ eji eme ihe nwere ike ịba ụba 25 mg kwa ụbọchị. Ogo ọgwụ kachasị akwadoro ọgwụ nwere ike ịbụ 25 mg.
A na-ahapụ ọgwụ a n'oge ọ bụla, n'agbanyeghị nri nri.
Ọ bụrụ n’ịchụrụ oge ị theụ ọgwụ ahụ, erila okpukpu abụọ nke ọgwụ kwa ụbọchị.
N'inwe oke mmụba nke akụrụngwa, ọgwụ adịghị atụ aro ọgwụ ahụ, n'ihi enweghị ike site na iji ọgwụ ahụ.
Ọ bụrụ na onye ọrịa ahụ nwere ọrịa imeju, nke na-egosipụta dị ka imeju imeju, ọ dịghị achọrọ ịmegharị ọgwụ a takenụrụ.
A naghị atụ aro ka ị theụọ ọgwụ ahụ mgbe ị na-ebu nwata na inye nwa ara, n'ihi enweghị data gbasara arụmọrụ yana nchekwa nke ọgwụ a maka nne na nwa n'oge a.
N'ihe banyere ọdịda akụrụngwa, ịdị mma nke ọgwụ na-adabere ogo nke ọdịda arụghị ọrụ.
A na-atụ aro ka ị nyochaa ọrụ akụrụ tupu ọgwụ ejiri ọgwụ, yana a na-atụ aro ka ị nyochaa ọrụ akụrụ ọ dịkarịa ala otu afọ n'oge iji Jardins.
Amachibidoro iji ọgwụ eme ihe na nwata. Mmachibido iwu a metụtara ndị ọrịa niile na-erubeghị afọ 18. Nke a bụ n'ihi enweghị nnyocha banyere ike na nchekwa nke ọgwụ.
A naghị atụ aro iji ọgwụ na ọgwụgwọ ndị ọrịa gafere afọ 75. Nke a bụ ihe ejikọtara ya na oke mmepe nke steeti akpọnwụ akpọnwụ.
Shouldkwesighi iji ngwaọrụ mgbe ị na-agwọ ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 1 na ọnọdụ ebe onye ọrịa ahụ nwere ketoacidosis onye ọrịa mamịrị.
Mgbe ị na-eji ọgwụ Jardins nke ọgwụ kachasị, ihe dị ka 113 mg nke lactose na-abanye n’ahụ onye ọrịa.
Ekwesighi iji ngwa a ma oburu na onye oria adiri oria lactase, anaghi anabata lactose ma obu glucose-galactose malabsorption n’anu ahu.
Nsonaazụ na contraindications mgbe ị na-eji ọgwụ
Mmetụta kachasị emetụta ị mostụ empagliflozin bụ mmalite nke mgbaàmà hypoglycemia.
Ọtụtụ mgbe, mmetụta dị n'ụdị hypoglycemia na-egosipụta onwe ya mgbe ị na-eji ọgwụ ahụ yana ngwakọta sulfonylurea ma ọ bụ insulin.
Na mgbakwunye na hypoglycemia, ndị ọrịa na-eji empagliflozin nwere ike ịnweta ọtụtụ nsonaazụ ndị ọzọ.
Nsonaazụ kachasị emetụta mgbe ị na-eji ọgwụ ahụ bụ ndị a:
- Ọdịdị nke ọrịa na-efe efe na nje ndị na-efe efe dịka vulvovaginitis, balanitis, candidiasis, vaginal, na urinary tract.
- N'ihi mgbanwe nke usoro metabolic na ahụ, hypovolemia nwere ike ime.
- Nnukwu mmụba na urination.
- Ihe omume nke ihe iriba ama nke akpukpo mmiri, nke anabatakariri ya na iji ogwu mee ihe n’ebe ndi agadi.
Nyocha banyere ọgwụ ahụ, ndị mmadụ ji ya mee ihe, na-egosi na mmetụta ndị ka njọ ọ na-eme n’ahụ onye ọrịa adịkarịghị obere. Mgbe ihe ịrịba ama mbụ nke mmetụta ndị ọ ga-apụta, ị ga-akwụsị ị theụ ọgwụ ahụ ma chọọ enyemaka dọkịta gị.
Ihe contraindications dị iche iche maka iji ọgwụ ọjọọ eme ihe bụ ndị a:
- ụdị shuga 1
- ọnụ ala zuru ụwa ọnụ
- ọrịa mamịrị ketoacidosis,
- lactose anagide ihe,
- ime na lactation,
- Ọnọdụ nke anụ ahụ nke na-eyi egwu ịba mmiri.
Tupu ị theụ ọgwụ ahụ, ịkwesịrị ịgakwuru dọkịta gị ma duzie nyocha nke anụ ahụ maka mgbochi ọ bụla.
Analogues nke ọgwụ ahụ, ọnụ ahịa yana mmekọrịta ya na ọgwụ ndị ọzọ
Na ahịa ọgwụ Russia, ọ bụ naanị ọgwụ Jardins, nke emere na ntọala nke empagliflozin, ka a na-ere. Site na nke anyị nwere ike ikwubi na enweghị ọgwụ analogues na ọgwụ a na ahịa Russia. Ndị ọrụ ndị ọzọ nwere àgwà hypoglycemic nwere mmetụta dị iche n'ahụ ahụ.
Ọnụ ego ọgwụ a na-akwụ dị na mpaghara a na-ere ọgwụ ahụ, yana ndị na-ebubata ọgwụ ahụ. Nkezi ego ọgwụ Jardins dị na Russia sitere na 850 ruo 1030 rubles.
Mgbe ị na-eji ọgwụ ahụ, ekwesịrị iburu n'uche na ọ nwere ike ịkwalite mmetụta diuretic nke ojiji nke ụfọdụ ihe ọkụkụ thiazide, nke nwere ike itinye aka na mmepe nke akpịrị ịkpọ nkụ na hypotension akwara.
Ihe a na-achọghị bụ nchikota Jardins na ọgwụ ndị emebere iji mee ka ọbara mgbali elu.
Ojiji insulin na-eme ihe n’otu oge, Jardins na ọgwụ na-eme ka imepụta homonụ eke nwere ike ịkpalite ngosipụta nke hypoglycemia. Mgbe ị na-eme ọgwụgwọ mgbagwoju anya, achọrọ imeziwanye usoro nke ọgwụ na nhazi nke ọgwụ n'okpuru nlekọta nke dibịa na-aga. Na vidiyo dị n’isiokwu a ga-ekwu gbasara ọgwụgwọ ọrịa shuga.
Ahịa maka jardins na ụlọ ahịa ọgwụ na Moscow
| mbadamba ihe mkpuchi | 10 mg | 30 PC | ≈ 2867,4 rub. |
| 25 mg | 30 PC | ≈ 2849 rub. |
Ndi dibia nyocha banyere jardins
| Ikwu oke 2.9 / 5 |
| Irè |
| Ahịa / mma |
| Nsonaazụ |
Ọ dị irè nke ukwuu megide glycemia, na-enye aka ịbelata oke.
Riskbawanye n'ihe egwu metụtara urogenital.
Ọgwụ a nwere mmetụta dị mma na glycemia, mana chọrọ ịdị ọcha mgbe niile, nke na-agaghị ekwe omume maka ndị ọrịa niile. Na-enweghị idebe iwu nke usoro ọgwụgwọ nri, enwere ike mepụta ndị gosipụtara metabolism metabolism na ndị ọrịa nwere mmụba dị ukwuu na glycemia. Redubelata nri kalori n'ihi iwepu glucose na mmamịrị bụ nsonaazụ ọzọ dị mma, agbanyeghị na oge na-aga.
| Ikwu oke 3.8 / 5 |
| Irè |
| Ahịa / mma |
| Nsonaazụ |
Ọ bụ ezigbo ọgwụ maka ndị ọrịa nwere ọrịa mellitus na ọrịa obi na-adịghị ala ala.
Mmamịrị n'ime ndị ọrịa a bụ sirop shuga, nke na-abawanye n'ihe ize ndụ nke ibute ọrịa metụtara ọrịa. Ndị ọrịa ga-akpachapụ anya na-ele ọcha ọcha. Achọrọ m icheta akụkọ FDA banyere ihe ize ndụ dị elu nke gangrene perineal n'ihi nnukwu ihe ize ndụ nke ibute ọrịa anụ ahụ.
Ogwu a bu udiri mgbanwe n’olu. Ọrịa shuga mellitus na-eji nwayọ ghọrọ ngalaba nke akwara obi, ọ bụkwa ọgwụ izizi nke mbụ na-achịkwa ọrịa shuga nke nwere uru doro anya na uru ya na sistem.
| Rating 4.2 / 5 |
| Irè |
| Ahịa / mma |
| Nsonaazụ |
Nnukwu hypoglycemic dị mma maka ụdị shuga 1. Ọgwụ ọgwụ inspoglycemic ndị ọzọ na insulin na-aga nke ọma. Ọ nwere mmetụta adịghị adị.
Ọnụahịa ahụ dị elu karịa nkezi.
Ọ na-arụ ọrụ ọfụma. Ndị ọrịa na-ahụta ịdị mma nke iji - oge 1 kwa ụbọchị, nke na-eme ka nnabata ya na onye ọrịa nwekwuo ike.
| Ikwu oke 5.0 / 5 |
| Irè |
| Ahịa / mma |
| Nsonaazụ |
Ọgwụ "Jardins" bụ nke kachasị dị irè n'oge a maka ịgwọ ọrịa shuga. Aha ọgwụ a na Russian Federation. Ọtụtụ ndị ọrịa na-akpọ ya "mbadamba insulin." A na-egosipụta mmetụta a ngwa ngwa. Taa, ọgwụ a bụ ihe ọzọ na insulin.
Nyocha ndị ọrịa Jardins
Oria a guzobere kemgbe afọ 2012. Ọgwụ adịghị eji ọgwụ ọ bụla belata, yabụ, etinyere ya insulin ngwa ngwa ruo afọ 3. Na mbu o debere nkeji 16-14, emesịa 18-16, na ọnwa anọ gara aga. 22-18 nkeji Mana dọkịta anaghị agbanwe ọgwụ, naanị na-abawanye ọgwụ. O wee mee, ndị Jardins mere ihe site na enyemaka enyemaka mmadụ, nyere ha nnwale. Mgbe ụbọchị atọ gachara, shuga - nkeji iri, na nkeji asatọ. Enwere m ike na ọchịchọ ibi ndụ! Mana ọ bụ otu ọnwa, ha anaghị ede akwụkwọ n'efu, enweghị ụzọ ịzụta ya. Ma ana m akwado nke ukwuu, maka ndị na-enweghị ọganihu na ọgwụgwọ, ọ ga-enyere aka.
Ọgwụ Farmacology
Ogwu hypoglycemic ọgwụ. Empagliflozin bụ onye agbanweegharị, na-agbasi mbọ ike, na-ahọrọ ma gbochie onye na-ebu mmanụ glucose ụdị sodium abụọ na-adabere n'ụdị ọ bụla achọrọ iji gbochie 50% nke ọrụ enzyme (IC)50), hà nmol 1.3. Nhọrọ nke empagliflozin ji okpukpu puku ise dị elu karịa n ’ụdị onye na-ebuga glucose n'ụdị 1 sodium na-ahụ maka nnabata nke glucose na eriri afọ.
Na mgbakwunye, achọpụtara na empagliflozin nwere oke nhọrọ maka ndị na-ebuga glucose ndị ọzọ na-ahụ maka glucose homeostasis n'ụdị anụ ahụ dị iche iche.
Thedị sodium na-ebugharị ụdị glucose dị mkpa bụ protein protein na-ebu maka nnabata nke glucose site na renal glomeruli azụ banye n'ọbara.
Empagliflozin na-emezi nchịkwa glycemic na ndị ọrịa nwere ọrịa shuga nke 2 site na ibelata realsorption akụrụ. Ọbara glucose na-eto site na akụrụ jiri usoro a dabere na ntinye glucose dị n'ọbara na GFR. Mmachi nke ndị na-ebu sodium na-ebute ụdị glucose ụdị 2 n'ime ndị ọrịa nwere ụdị shuga 2 na hyperglycemia na-eduga na mkpocha glucose oke site na akụrụ.
N'ime ule nke ụlọ ọgwụ, achọpụtara na na ndị ọrịa nwere ọrịa shuga 2, akụrụ na-enwewanye glucose ngwa ngwa mgbe etinyere ọkwa mbụ nke empagliflozin, mmetụta a gara n'ihu ruo awa 24. Mmụba nke iwere glucose site na akụrụ gara n'ihu ruo mgbe ngwụsị nke oge izu 4. ihe eji emechi emagliflozin na 25 mg 1 oge / ubochi, na nkezi, ihe dika 78 g / ubochi. N'ime ndị ọrịa nwere ụdị ọrịa shuga nke 2, mmụba nke mkpụmkpụ nke akụrụ mere ka mbelata nke mkpụkọ glucose ozugbo na plasma ọbara.
Empagliflozin na -ebelata mkpokọ glucose na plasma ọbara ma n'okwu ọnụ na mgbe e risịrị nri.
Usoro nke empagliflozin na-adabere na ọnọdụ arụmọrụ nke mkpụrụ ndụ panc-pancreatic and na metabolulin metabolism. Achọpụtara mmetụta dị mma nke empagliflozin na akara ndị nọchiri anya ọrụ nke mkpụrụ ndụ β, gụnyere ntụpọ HOMA-β (ihe atụ maka inyocha homeostasis) na oke nke proinsulin na insulin. Na mgbakwunye, iwepụ glucose ọzọ site na akụrụ na-eme ka a ghara inwe calorie, nke na-esobelata olu nke anụ ahụ adipose na mbelata nke ahụ.
A na-ahụkarị Glucosuria n'oge eji empagliflozin yana ntakịrị mmụba na diuresis, nke nwere ike itinye aka na mbelata ọbara mgbali elu.
Na omumu ihe omumu ebe ejiri ogwu mee ihe dika monotherapy, ihe nchikota ya na metformin, nnwekorita ogwu na metformin na ndi oria a choputara oria ohuru mellitus, oria mmado ya na metformin na uzo ogwu, ihe nchikota ya na pioglitazone +/- metformin, ijikota ogwu na linagliptin na ndị ọrịa nwere ụdị ọrịa shuga abụọ ọrịa mellitus ọhụrụ, ọgwụgwọ njikọta na linagliptin, nke agbakwunyere na usoro ọgwụgwọ metformin, jikọtara ter FDI nwere metformin na glimepiride (data sitere n'ọmụmụ afọ 2), ọgwụgwọ ngwakọta na insulin (ọtụtụ injections insulin) +/- metformin, ọgwụgwọ ngwakọta na insulin basal, ọgwụ ngwakọta na dipeptidyl peptidase-4 inhibitor (DPP-4), metformin +/- Egosila ọgwụ ọgwụ hypoglycemic ọzọ gosipụtara na ọ nwere mbelata dị ukwuu na haemoglobin glycosylated (HbA1c), mbelata nke ibu glucose plasma na-ebu ọnụ, yana mbelata ọbara mgbali elu na oke ahụ.
Mlọ ọgwụ
A mụọla ọgwụ ọgwụ nke empagliflozin nke ọma na ndị ọrụ afọ ofufo ahụike na ndị ọrịa nwere ụdị shuga 2.
Mgbe imesịrị, a na-etinye empagliflozin ngwa ngwa, Cmax A na-erute empagliflozin na plasma ọbara mgbe awa 1.5 gachara, ịta ọkwa nke empagliflozin na plasma na-ebelata biphasic. Nkezi AUC n'oge plasma ịta ahụhụ bụ 4740 nmol × h / l, na ọnụahịa Cmax - 687 nmol / L. Iri nri adighi enwe ogwu di egwu banyere ogwu ogwu nke empagliflozin.
Ndị ọgwụ ọgwụ empagliflozin na ndị ọrụ afọ ofufo nwere ahụike na ndị ọrịa nwere ụdị ọrịa shuga 2 bụ ọrịa mellitus n'ozuzu yiri.
Ised oge itinye uche na plasma nke ọbara na-eme ihe dịka 73.8 l. Mgbe nchịkwa ọnụ gasịrị site n'aka ndị ọrụ afọ ofufo nwere ahụike nke akpọrọ empagliflozin 14 C, mmachi na protein plasma bụ 86%. Mgbe ị na-eji empagliflozin 1 oge / ụbọchị Css na plasma ruru mgbe ihe nke ise gasịrị.
Mainzọ kachasị nke metabolagliflozin metabolism n’ime mmadụ bụ glucuronidation na ntinye nke uridine-5'-diphospho-glucuronosyltransferases UGT2B7, UGT1A3, UGT1A8 na UGT1A9. Ihe ndị na-ahụkarị metabolites nke empagliflozin bụ glucuronide atọ (2-O, 3-O na 6-O glucuronide). Mmetụta sistemụ nke metabolite ọ bụla dị ntakịrị (ihe na-erughị 10% nke ngụkọta nke empagliflozin).
Ndi1/2 odika elekere 12.4. Mgbe abatasịrị nke akpọrọ empagliflozin 14 C n'ime ndị ọrụ afọ ofufo mara mma, ihe dịka 96% nke ọgwụ ahụ ka ewepụrụ (site na eriri afọ - 41%, akụrụ - 54%). Site na eriri afọ, ọtụtụ n'ime ọgwụ akpọrọ agbanweela agbanweghị. Ọ bụ nanị ọkara nke ọgwụ akpọrọ ahaghị ya na akụrụ na-agbanweghị.
Pharmacokinetics na otu ọrịa ọrịa pụrụ iche
N'ime ndị ọrịa nwere ajọ akụrụngwa dị nro, na-akwụkarị ọtọ (30 2) yana ndị ọrịa nwere ọdịda akụrụngwa njedebe, AUC nke empagliflozin mụbara ihe dịka 18%, 20%, 66%, na 48%, otu ọ bụla, ma e jiri ya tụnyere ndị ọrịa nwere ọrụ nkịtị. akụrụ. N'ime ndị ọrịa nwere ezughị oke gbasara akụrụngwa yana ndị ọrịa nwere ọkwa ọdịda ezughi okemax empagliflozin na plasma yiri ụkpụrụ kwekọrọ na ndị ọrịa nwere ọrụ gbasara ụlọ ọrụ. N'ime ndị ọrịa nwere nnukwu akụrụ siri ikemax empagliflozin na plasma dị ihe dị ka 20% karịa ndị ọrịa nwere ọrụ mkpo nkịtị. Nchịkọta nyocha nke ndị na-ahụ maka ọgwụ na onu ogugu na-egosi na mkpochapụ nke empagliflozin belatara na ibelata GFR, nke butere mmụba na ọgwụ ahụ.
N'ime ndị ọrịa nwere ọria ịgwọ ọrịa dị nwayọ, na-adigide, na nnukwu ọrịa (dịka nhazi nke ụmụaka-Pugh), ụkpụrụ AUC nke empagliflozin mụbara ihe dịka 23%, 47%, na 75%, n'otu n'otu, na Cmax odika 4%, 23% na 48%, n’otu n’otu (ma e jiri ya tụnyere ndị ọrịa nwere ọrụ imeju nkịtị).
BMI, okike, agbụrụ, na afọ enwebeghị mmetụta dị mkpa na ụlọ ọgwụ na ọgwụ ọgwụ nke empagliflozin.
Emebeghị nnyocha banyere ọgwụ ọgwụ nke empagliflozin n'ime ụmụaka.
Mpempe mwepụta
Mbadamba mbadamba, nke ihe mkpuchi na-acha odo odo, na-acha odo odo na agba, gburugburu, biconvex, nwere akụkụ gbara agba, kanyere akara na ụlọ ọrụ n'otu akụkụ yana "S10" n'akụkụ nke ọzọ.
| Taabụ 1 | |
| empagliflozin | 10 mg |
Ndị na-ahụ maka ihe: lactose monohydrate - 162.5 mg, microcrystalline cellulose - 62.5 mg, hyprolose (hydroxypropyl cellulose) - 7.5 mg, croscarmellose sodium - 5 mg, sillofon silicon dioxide - 1.25 mg, magnesium stearate - 1.25 mg.
Ihe mejupụtara Shell: Opadry edo edo (02B38190) - 7 mg (hypromellose 2910 - 3.5 mg, titanium dioxide - 1.733 mg, talc - 1.4 mg, macrogol 400 - 0.35 mg, iron oxide odo - 0.018 mg).
10 PC. - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
A na-ewere ọgwụ ọnụ, n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri a na-eri.
Usoro akwadoro ịmalite bụ 10 mg 1 oge / ụbọchị. Ọ bụrụ na kwa ụbọchị nke 10 mg anaghị enye njikwa glycemic zuru oke, enwere ike ịbawanye dose ahụ gaa 25 mg 1 oge / ụbọchị.
Oke kachasị kwa ụbọchị bụ 25 mg.
Mgbe ịwụsịrị ọgwụ, onye ọrịa ahụ kwesịrị ị takeụ ọgwụ ọgwụ ozugbo o chetara nke a. Ejila okpukpu abụọ n’ime otu ụbọchị.
Maka ndị ọrịa nwere nsogbu gbasara akụrụ na GFR site na 45 ruo 90 ml / min / 1.73 m 2, achọrọ ịgbanwe ndozi. N'ime ndị ọrịa nwere ọdịda akụrụ na GFR 2, a naghị atụ aro ka a na-a theụ ọgwụ ahụ n'ihi enweghị ike.
Ọchọghị ndị ọrịa nwere nsogbu ọria imeju ha.
Mmekorita
Empagliflozin nwere ike ịkwalite mmetụta diuretic nke thiazide na "loop", nke, n'aka nke ya, nwere ike ịbawanye ihe ize ndụ nke akpịrị ịkpọ nkụ na hypotension akwara.
Insulin na ọgwụ na-eme ka ihe nzuzo ya dịkwuo elu, dị ka sulfonylureas, nwere ike ịbawanye ohere nke hypoglycemia. Ya mere, n'iji insagliflozin na-ejikọ ya na insulin na ọgwụ na-eme ka nzuzo ya dịkwuo elu, ọ nwere ike ịdị mkpa iji belata ọgwụ ha, iji zere ihe ize ndụ nke hypoglycemia.
Na ntule mmekọrịta nyocha ọgwụ ọgwụ vitro. Empagliflozin anaghị egbochi, inactivate, ma ọ bụ kpalite CYP450 isoenzymes. Routezọ nke metabolism nke empagliflozin dị n’ime mmadụ bụ glucuronidation yana ntinye nke uridine-5’-diphospho-glucuronosyltransferases UGT2B7, UGT1A3, UGT1A8 na UGT1A9. Empagliflozin anaghị egbochi UGT1A1. Mkparịta ụka ọgwụ ọjọọ nke empagliflozin na ọgwụ ndị na-anọchi anya CYP450 na UGT1A1 isoenzymes bụ ihe a na-agaghị ele anya.
Empagliflozin bụ mkpụrụ maka P-glycoprotein yana mgbochi ọrịa ara ure na-ekpebi protein (BCRP), mana anaghị egbochi protein ndị a na usoro ọgwụgwọ. Dabere na data sitere na ọmụmụ nke vitro, ekwenyere na ike nke empagliflozin soro ndị ọgwụ na-eji dochie anya P-glycoprotein enweghị atụ. Empagliflozin bụ mkpụrụ maka ndị na - eburu ikuku anionic: OAT3, OATP1B1 na OATP1B3, mana abụghị ihe ndabere maka ndị na - eburu ikuku anionic 1 (OAT1) na ndị na - ebu cationic 2 (OST2). Ka osiladi, mmekorita ogwu nke empagliflozin ya na ogwu nke bu ihe dochie anya umu ihe ndi n’echebara uzo akowara n’elu di ka ekwesighi.
Na ntule mmekọrịta mkparịta ụka nke vivo. Site na ijiri empagliflozin na ọgwụ ndị ọzọ a na-ejikarị, ọ nweghị mmekọrịta ọgwụ ọgwụ dị ịrịba ama achọpụtara. Nsonaazụ nke ọmụmụ pharmacokinetic na-egosi na ọ dịghị mkpa ịgbanwe mkpụrụ ọgwụ ọgwụ Jardins while ka a na-eji ọgwụ ndị a na-ejikarị eme ya.
Aclọ ọgwụ ọgwụ nke empagliflozin anaghị agbanwe agbanwe na ndị ọrụ afọ ofufo mara mma mgbe ejiri ya na metformin, glimepiride, pioglitazone, sitagliptin, linagliptin, warfarin, verapamil, ramipril, simvastatin, torasemide na hydrochlorothiazide. Combinedjikọtara ojiji nke empagliflozin na gemfibrozil, rifampicin na probenecid gosipụtara mmụba na AUC nke empagliflozin site na 59%, 35% na 53%, n'otu n'otu, mana echeghị mgbanwe ndị a dị ka ọgwụ.
Empagliflozin enweghị mmetụta dị egwu na ọgwụ na ọgwụ ọgwụ nke metformin, glimepiride, pioglitazone, sitagliptin, linagliptin, warfarin, digoxin, ramipril, simvastatin, hydrochlorothiazide, torasemide na ọgwụ mgbochi na mma na ndị ọrụ afọ ofufo.
Nsonaazụ
Ọnọdụ dị njọ nke ihe ọjọọ na ndị ọrịa na-anata empagliflozin ma ọ bụ placebo bụ otu ihe ahụ na ọmụmụ ụlọ ọgwụ. Mmeghachi omume kachasị emetụta bụ hypoglycemia, bụ nke a hụrụ site na iji nke empagliflozin yana yana sulfonylurea ma ọ bụ ọgwụ insulin.
Mmeghachi omume ọjọọ ndị a hụrụ na ndị ọrịa na-anata empagliflozin n'ọmụmụ ihe nchịkwa placebo ka e gosipụtara n'okpuru ebe a dabere na nhazi nke akụkụ na sistemụ na usoro akara aka MedDRA na-egosi oge ha zuru oke. A kọwapụtara otu ugboro ugboro dị ka ndị a: ọtụtụ mgbe (≥1 / 10), ọtụtụ mgbe (site na ≥1 / 100 ruo 2,
N'iji nlezianya: ndị ọrịa nwere nsogbu nke ịmalite hypovolemia (iji ọgwụ antihypertensive nwere akụkọ banyere hypotension), yana ọrịa na eriri afọ na-eduga na mbufu mmiri, ọrịa urogenital, na-ejikọ ya na ọgwụ ma ọ bụ insulin, nri obere carb, ketoacidosis na-arịa ọrịa shuga. akụkọ ihe mere eme, obere ọrụ nzuzo nke mkpụrụ ndụ beta nke pancreatic, ndị ọrịa karịrị afọ 75.
Ime na lactation
A na-egbochi ojiji nke empagliflozin n'oge afọ ime n'ihi data ezughi oke na arụmọrụ yana nchekwa.
A na - egbochi contraagliflozin maka inye ara ara. Ihe omimi enwetara na omumu omumu banyere umu anumanu na egosi ezi nnabata nke mmiri ara ura. E wezuga ihe ize ndụ nke ịmara ụmụ ọhụrụ na ụmụaka ara ara. Ọ bụrụ na ọ dị mkpa iji empagliflozin n'oge ara, a ga-akwụsị ịhapụ inye ya ara.
Jiri maka ọrụ ezighi ezi na-arụ ọrụ
Ofdị irè nke ọgwụ Jardins ® na-adabere na ọrụ nke akụrụ. Ya mere, a na-atụ aro ka nyochaa ọrụ akụrụngwa tupu oge a ga-eme ya ma oge site n'oge ọgwụgwọ (ọbụlagodi oge 1 kwa afọ), yana tupu agbapụta usoro ọgwụgwọ, nke nwere ike imetụta ọrụ akụrụ.
Maka ndị ọrịa nwere nsogbu gbasara akụrụ na GFR site na 45 ruo 90 ml / min / 1.73 m 2, achọrọ ịgbanwe ndozi. N'ime ndị ọrịa nwere ọdịda akụrụ na GFR 2, a naghị atụ aro ka a na-a theụ ọgwụ ahụ n'ihi enweghị ike.
Jiri ndị ọrịa agadi
Ndị ọrịa dị afọ iri asaa na ise gbagowe nwere nsogbu nke mmiri akpọnwụ akpọnwụ. N'ime ndị ọrịa dị otú a na-emeso empagliflozin, a na-ahụkarị mmeghachi omume ọjọọ nke hypovolemia ugboro ugboro (ma e jiri ya tụnyere ndị ọrịa na-anabata placebo).
Ahụmịhe banyere ojiji nke empagliflozin na ndị ọrịa karịa afọ 85 dị obere, yabụ, anaghị atụ aro ka o nye ọgwụ ndị ọrịa Jardins ® nke otu ọgbọ a.
-
Ntinye ihe oriri E955
Kedu ihe bụ mgbakwunye nri nri E955 - sucralose? Kedu ihe bụ nri mgbakwunye E955 ma ọ bụ sucralose? ... -
-
-
