Isofan Insulin > Insulin

Elldị shuga abụọ nke ọrịa shuga, ọkwa nke iguzogide ọgwụ ọgwụ hypoglycemic, nke na-egbochi ọgwụ hypoglycemic nke ọgwụ (njikọta ọgwụ), ọrịa na-efe efe, usoro ịwa ahụ (mono-ma ọ bụ ọgwụ ọgwụgwọ), ọrịa shuga mellitus n'oge afọ ime (ya na ọgwụgwọ nri anaghị arụ ọrụ).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

P / C, 1-2 ugboro n'ụbọchị, nkeji iri atọ ruo iri anọ na ise tupu nri ụtụtụ (gbanwee ebe ngbanye oge niile). N'ọnọdụ ndị pụrụ iche, dọkịta nwere ike inye ọgwụ ọgwụ / ọgwụ m. Na / na ntinye insulin nke ọkara oge amachibidoro! A na-ahọrọ doses n'otu n'otu ma dabere na ọdịnaya nke glucose n'ọbara na mmamịrị, njirimara nke ihe ọrịa ahụ. Dịka ọ dị, usoro onunu ogwu ya bụ 8-24 IU 1 oge kwa ụbọchị. N'ime ndị okenye na ụmụaka nwere nnukwu mmetụta nke insulin, ọgwụ na-erughị 8 IU / ụbọchị nwere ike zuru ezu, n'ime ndị ọrịa nwere ọgụgụ isi - karịa 24 IU / ụbọchị. Na usoro ubochi gafere 0.6 IU / n'arọ, - n'ụdị injections abụọ dị iche iche. Ndị ọrịa na-anata 100 IU ma ọ bụ karịa kwa ụbọchị, mgbe ha na-edochi insulin, ọ bụ ihe amamihe dị na ya ịga ụlọ ọgwụ. Ekwesịrị ịgbanwe site na otu ọgwụ gaa n'ọzọ n'okpuru nchịkwa nke glucose ọbara.

Omume ọgwụ

Ọgwụ insulin na-arụ ọrụ. Na -ebelata mkpụkọ nke glucose n'ọbara, na-eme ka nnabata ya dịkwuo elu site na anụ ahụ, na-eme ka lipogenesis na glycogenogenesis, njikọ protein, na-ebelata ọnụego glucose na-emepụta site na imeju.

Ọ na - emekọrịta otu onye na - anabata ihe n'ụsọ akpụkpọ ahụ ma mepụta ebe nnabata insulin dị. Site na ịgbalite njikọta nke cAMP (n'ime sel ndị dị abụba na akwara) ma ọ bụ banye n'ime sel (akwara), ihe nnabata insulin na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthetase, wdg). Mbelata nke glucose ọbara bụ n'ihi mmụba na njem ya na intracellular, mmụba dị ukwuu na njigide anụ ahụ, mkpali nke lipogenesis, glycogenogenesis, njikọ protein, mbelata ọnụego glucose na-emepụta site na imeju (ibelata na mmebi glycogen), wdg.

Mgbe ọ gbasịrị sc, mmetụta ahụ na-apụta na awa 1-1.5. Mmetụta kachasị dị na etiti oge dị n'etiti awa 4-12, oge nke ime ihe bụ awa iri na abụọ ruo iri abụọ na anọ, dabere na nhazi nke insulin na ntinye ya, na-egosipụta ihe dị iche na ntughari nke onwe.

Nsonaazụ

Mmeghachi omume nfụkasị ahụ (urticaria, angioedema - fever, ụkwara ume ọkụ, mbelata ọbara mgbali),

hypoglycemia (pallor nke anụ ahụ, ịba ụba ọsụsọ, ọsụsọ, palpitations, ịma jijiji, agụụ, agụụ, nchekasị, paresthesias n'ọnụ, isi ọwụwa, ụra, ehighị ụra nke ọma, ụjọ, ọnọdụ ịda mbà n'obi, mgbakasị ahụ, omume na-enweghị atụ, enweghị mmeghari, ikwu okwu na nsogbu okwu na ọhụụ), hypoglycemic coma,

hyperglycemia na ọrịa shuga acidosis (na obere doses, injections ski, nri na-adịghị mma, na ahụ ọkụ na ọrịa): iro ụra, akpịrị ịkpọ nkụ, agụụ nri, ọdịdị ihu).

isi mmụọ (ruo na mmepe nke precoatose na coma),

nsogbu adịghị ahụ anya (yana oge mmalite ọgwụ),

mmeghachi omume immunological na insulin nke mmadụ, mmụba na ụzọ nke ọgwụ mgbochi insulin, mmụba nke glycemia,

hyperemia, itching na lipodystrophy (atrophy ma ọ bụ ọbara mgbali nke abụba subcutaneous) na ntụtụ.

Na nmalite ọgwụgwọ - mmerụ ahụ na mgbakasị ahụ (na-adị nwa oge na-aga n’ihu na ọgwụgwọ na-aga n’ihu). Ọria: ngbali, palpitations, ịma jijiji, agụụ, ụjọ, paresthesia n'ọnụ, pallor, isi ọwụwa, ura, ehighị ụra, ụjọ, ọnọdụ obi erughị ala, mgbakasị ahụ, omume na-enweghị atụ, enweghị mmegharị, ikwu okwu na ọhụụ, coma hypoglycemic coma, nkwarụ.

Ọgwụgwọ: ọ bụrụ na onye ọrịa ahụ maara, a na-edenye ya ọgwụ edere, s / c, i / m ma ọ bụ iv glu gluagon ma ọ bụ iv hypertonic dextrose. Site na ntinye nke hypoglycemic coma, 20-40 ml (ihe ruru 100 ml) nke mmiri 40% dextrose na-abanye n'ime iyi ruo mgbe onye ọrịa ahụ si na Coma pụta.

Ntụziaka pụrụ iche

Tupu iwere insulin site na vial ahụ, ọ dị mkpa iji nyochaa nghọta nke ihe ngwọta. Mgbe ozu ndị si mba ọzọ pụtara, na-ekpuchi ma ọ bụ na-ebute ihe dị na karama ahụ, enweghị ike iji ọgwụ a .ụ ọgwụ.

Okpomoku nke mmanu insulin kwesiri ino na okpomoku.

Aga-emeghari etu o kwesiri isi gbanwee insulin n'ihe banyere ọrịa na-efe efe, ọ bụrụ na nsị nke gland thyroid, ọrịa Addison, hypopituitarism, ọdịda akụrụ na-adịghị ala ala na ọrịa mellitus na-arịa mmadụ karịa afọ 65.

Ihe ndị na - akpata hypoglycemia nwere ike ịbụ: ịdoụ ọgwụ insulin, ị replacementụ ọgwụ, nzere nri, vomiting, afọ ọsịsa, nchekasị anụ ahụ, ọrịa na-ebelata mkpa insulin (ọrịa akụrụ na akụrụ na hypofunction nke adrenal cortex, pituitary ma ọ bụ thyroid gland), mgbanwe nke ebe inje (dịka ọmụmaatụ, anụ dị n’afọ, ubu, apata ụkwụ), yana ịmekọrịta ọgwụ ndị ọzọ. O kwere omume belata mkpụkọ glucose dị n'ọbara mgbe ị na-ebufe onye ọrịa site na insulin anụmanụ n'ime insulin nke mmadụ. Ibugharị onye ọrịa na insulin mmadụ kwesịrị ịbụ ihe ziri ezi mgbe nile ọfụma ma mekwa ya naanị n'okpuru nlekọta nke dibia.

Omume nke ịmalite hypoglycemia nwere ike imebi ikike nke ndị ọrịa ikere òkè zuru oke na okporo ụzọ, yana idozi igwe na usoro.

Ndị ọrịa nwere ọrịa shuga nwere ike ịkwụsị ntakịrị hypoglycemia ha na-enwe site na iri shuga ma ọ bụ nri nwere oke carbohydrates (a na-atụ aro ka gị na shuga dịkarịa ala 20 g). Banyere hypoglycemia a na-ebugharị, ọ dị mkpa ịgwa ndị dibịa bekee ka ọ kpebie mkpa ọgwụgwọ mgbazi dị. N'oge afọ ime, ọ dị mkpa iburu n'uche mbelata (M trimester) ma ọ bụ mmụba (II-III trimesters) nke insulin chọrọ. N'oge na mgbe amuchara nwa, ihe ndi choro insulin nwere ike igbadata nke ukwuu. N'oge a na-enye nwa ara, a na-achọ nlele kwa ụbọchị ruo ọtụtụ ọnwa (ruo mgbe a gbanwere mkpa insulin).

Mmekorita

N ’ogwu ọgwụ ekwekọghị na ọgwụ nke ọgwụ ndị ọzọ.

A na - eme ka mmetụta hypoglycemic dị na sulfonamides (gụnyere ọgwụ hypoglycemic ọgwụ, sulfonamides), MAO inhibitors (gụnyere furazolidone, procarbazine, selegiline), ndị na-egbochi carbon anhydrase inhibitors, ndị na-egbochi ACE, ndị na-egbochi NSAIDs (gụnyere salicylates), anabolic (gụnyere stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li +, pyridoxine, quinidine, quinine, chloroquin.

Hypoglycemic mmetụta nke isi glucagon, ibu hormone, corticosteroids, onu gbochie afọ, estrogens, thiazide na loop diuretics, BCCI, thyroid homonụ, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, calcium na-akụ ọkpọ, diazoxide, morphine, wii wii, nicotine, phenytoin, epinephrine, H1-histamine na-anabata ihe mgbochi.

Beta-egbochi, reserpine, octreotide, pentamidine nwere ike ịkwalite ma mee ka ike gwụ hypoglycemic mmetụta nke insulin.

Ihe ngosi maka ojiji na aha ahia ogwu

Ejiri ọgwụ a gosipụtara maka ụdị ọrịa shuga na-adabere na ọrịa shuga. Ọzọkwa, usoro ọgwụgwọ kwesịrị ịdị ogologo ndụ.

Insulin dị ka Isofan bụ ọgwụ eji emepụta mkpụrụ ndụ ihe nketa enyere mmadụ n'ụkpụrụ ndị a:

ụdị shuga 2 (insulin-dependance),
usoro ịwa ahụ
iguzogide ndị ọrịa hypoglycemic weere ọnụ dị ka akụkụ nke ọgwụgwọ siri ike,
ọrịa afọ ime (na enweghị uru ọgwụgwọ ọgwụ),
ihe omumu ogwu.

Companieslọ ọrụ na-emepụta ọgwụ na-emepụta insulin nke nwere mkpụrụ ndụ ihe n’okpuru aha dị iche iche. Ndị kachasị ewu ewu bụ Vozulim-N, Biosulin-N, Protafan-NM, Insuran-NPH, Gensulin-N.

A na-ejikwa ụdị insulin insulin ndị ọzọ nwere aha aha ndị a:

Adighi ike
Humulin (NPH),
Pensulin,
Isofan insulin NM (Protafan),
Actrafan
Insulidd N,
Biogulin N,
Protafan-NM Penifill.

Okwesiri iburu n'uche na ojiji nke dọkịta insulin Isofan kwesiri ekwenye.

Usoro onunu ogwu na nhazi

Ntụziaka maka iji insulin Isofan kwupụta na a na-enye ya subcutaneously ugboro abụọ n'ụbọchị tupu nri ụtụtụ (nkeji 30-45). N'okwu a, ịkwesịrị ịgbanwe ebe ntụtụ ụbọchị kwa ụbọchị ma chekwaa sirinji a na-eji eme ụlọ okpomọkụ, yana nke ọhụrụ na friji.

Mgbe ụfọdụ a na-a adminụ ọgwụ ahụ intramuscularly. Intzọ ọbara n'ime iji insulin eme ihe na-adịghị arụ ọrụ ihe fọrọ nke nta ka ọ bụrụ na ejighị ya.

A na-agbakọta usoro onunu ogwu ahụ n'otu oge maka onye ọrịa ọ bụla, dabere na ọkwa shuga na mmiri ọmụmụ yana nkọwa nke ọrịa ahụ. Dịka iwu, nkezi usoro ubochi kwa ụbọchị sitere na 8-24 IU.

Ọ bụrụ na ndị ọrịa nwere insensensitivity na insulin, mgbe ahụ, ezigbo ọgwụ kwa ụbọchị bụ 8 IU. Site na ịba uru nke homonụ ahụ, usoro ịba ụba na-abawanye - site na 24 IU kwa ụbọchị.

Mgbe ogo ọgwụ kwa ụbọchị karịrị 0.6 IU kwa 1 n'arọ nke uka, mgbe ahụ, a na-eme inje 2 n'akụkụ ahụ dị iche iche. Ndị ọrịa nwere otu ọgwụ kwa ụbọchị nke 100 IU ma ọ bụ karịa kwesịrị ịga ụlọ ọgwụ ma ọ bụrụ na edochi insulin.

Ọzọkwa, mgbe ị na-ebufe otu ụdị ngwaahịa gaa na nke ọzọ, ọ dị mkpa iji nyochaa ọdịnaya shuga.

Mmeghari Ahụhụ yana dofịkasị

Ojiji insulin mmadu nwere ike ime ka ekpughere ekpughe. Ọtụtụ mgbe, ọ bụ angioedema (hypotension, umi ume, fever) na urticaria.

Ọzọkwa, ịgafe usoro onunu ogwu nwere ike ibute hypoglycemia, nke ihe mgbaàmà ndị a gosipụtara:

ehighi ura
akpụkpọ ahụ,
ịda mba
hyperhidrosis
tua egwu
obi ụtọ ala
palpitations
isi ọwụwa
ndaba,
ọgba aghara vestibular
agụụ
ịma jijiji na ihe.

Mmetụta dị n'akụkụ ya gụnyere akpịrị acidosis na hyperglycemia, nke ọdịdị ihu na-egosipụta, ụra, nri agụụ na akpịrị ịkpọ nkụ. Ọtụtụ mgbe, ọnọdụ ndị dị otú ahụ na-ebilite megide nzụlite nke ọrịa na-efe efe na ahụ ọkụ, mgbe a na-efu ntụgharị, usoro ị theụ ọgwụ adịghị mma, ma ọ bụrụ na esoghị nri ahụ.

Mgbe ụfọdụ imebi mmụọ na-eme. N'ọnọdụ ndị siri ike, a na-amalite inwe precoatous na coma stema.

Na nmalite ọgwụgwọ, obere ọrụ na-eduga n'ịrụ ọrụ nwere ike ime. A na-ahụta mmụba na ụzọ ụzọ ọgwụ insulin na-enwewanye ọganihu nke glycemia na mmeghachi omume immunological nke ọdịdị obe na insulin mmadụ.

Oge ụfọdụ ka ọgwụ ịgba gburugburu na-efegharị na ọnya afọ. N'okwu a, hyperrophies anụ ahụ subcutaneous ma ọ bụ atrophies. Ma n’oge usoro ọgwụgwọ mbụ, njehie na edema nwere ike ime nwa oge.

Ọ bụrụ na ị doụbiga ọgwụ ọ hormonụ hormonụ ókè, ọbara shuga dị elu nke ukwuu. Nke a na - akpata hypoglycemia, mgbe ụfọdụ onye ọrịa na - adaba na mmiri.

Ọ bụrụ n ’ufere dị ntakịrị, ị ga-a takeụ nri carb dị elu (chocolate, achịcha ọcha, mpịakọta, swiiti) ma ọ bụ drinkụọ mmanya dị ụtọ nke ukwuu. N'ọnọdụ nkụda mmụọ, a na-enye onye ọrịa ọgwụ elektrose (40%) ma ọ bụ glucagon (s / c, v / m).

Mgbe onye ọrịa nwetaghachiri, ọ dị mkpa inye ya nri n'ụba carbohydrates.

Nke a ga - egbochi nlọghachi hypoglycemic na glycemic coma.

Olee otu o si arụ ọrụ

Isofan insulin nke mkpụrụ ndụ ihe nketa mmadụ na-emetụta ahụ, na-arụ ọrụ hypoglycemic. Ọgwụ a na-abanye na ndị na-anabata cytoplasmic nke akpụkpọ ahụ. Nke a na-emepụta ogige nnabata insulin. Ọrụ ya bụ ime ka metabolism dị n’ime mkpụrụ ndụ na-arụ ọrụ n’onwe ha, nyekwa aka na njikọ nke isi enzymes niile dị adị.

Cingbelata ogo shuga dị n’ọbara na-ewere ọnọdụ site na ịbawanye ụba n’ime njem ya n’ime sel, yana iwelata ọnụego mmepụta shuga, site n’inyere aka n’itinye mmiri. Uru ọzọ insulin na-eme bụ njikọta protein, ịgbalite nke lithogenesis, glycogenogenesis.

Ogologo oge ole ọgwụ a na - eme ihe kwekọrọ na ọnụego nnabata ọgwụ a n'ọbara, usoro nnabata ahụ dabere na usoro nchịkwa ya na oke ọgwụ ahụ. Ya mere, nsonaazụ nke ọgwụ a dị iche na ndị ọrịa dị iche iche.

Omenala, mgbe ogwu ogbugba gasịrị, nsonaazụ nke ọgwụ amalite mgbe awa 1.5 gachara. Ọnụ ọgụgụ kasị elu nke ịdị irè pụtara na isi ihe 4 awa mgbe nchịkwa ọgwụ ahụ. Oge o mere bụ awa iri abụọ na anọ.

Ọnụ ọgụgụ nke Isofan na-adabere n'ihe ndị a:

Ebe ntinye (buttock, afo, apata),
Ọrụ umi itinye n'ọrụ
Dose.

Ọkpụkpụ a na-amịpụta ọgwụ a.

Etu esi eme: ihe ngosiputa maka ojiji

Dabere na ntuziaka maka Isofan, a ga-achịrịrị ya subcutaneously ugboro abụọ n'ụbọchị: n'ụtụtụ na n'anyasị tupu nri (nkeji 30-40 tupu eri). Ekwesịrị ịgbanwe saịtị sirinji kwa ụbọchị, ekwesịrị ịchekwa sirinji eji eme ihe na nkịtị, okpomọkụ nkịtị, na nke ọhụrụ kwesịrị ịdị na nkwakọ ngwaahịa ahụ, na friji. N’oge na-adịghị anya, a na-abanye ọgwụ a n’arụ ahụ, mana ọ naghị abụkarị intraven, n’ihi na ọ bụ insulin na-arụ ọrụ.

A na-agbakọ ọ̀gwụ nke ọgwụ a n'otu n'otu maka onye ọ bụla na-arịa ọrịa shuga, na nyocha ya na dibia bekee. Dabere n’otú shuga dị na plasma na banyere ọrịa shuga. Nkezi nha kwa ubochi, dika omenala si di nke 8-24 IU.

N'ọnọdụ insulin, ọ dị mkpa ịghara ịfe ihe karịrị 8 IU kwa ụbọchị, ọ bụrụ na achọpụtaghị homonụ nke ọma, enwere ike ịbawanye ọnụọgụ ahụ ruo 24 ma ọ bụ karịa IU n'ụbọchị. Ọ bụrụ na ọgwụ kwa ụbọchị ga-agafe 0. 6 IU kwa kilogram nke ịdị arọ ahụ nke onye ọrịa, mgbe ahụ, a na-eme inje 2 n'otu oge n'otu ebe dị iche iche.

Urticaria,

Dodoụfe ọgwụ ọgwụ a juputara na hypoglycemia na coma. Enwere ike ịgabiga ọgwụ a ma ọ bụrụ na ị rie nri oke na carbohydrates (chocolate, swiiti, kuki, tii dị ụtọ).

Ọ bụrụ na amaghị ama, a ga-enye onye ọrịa ọsịsọ ihe ndozi nke Dextrose ma ọ bụ Glucagon. Mgbe nsụhọ ga-alaghachi, a ga-enye onye ọrịa nri nri oke carbohydrates. Nke a ga - eme ka o kwe omume izere ma glycemic coma na hypoglycemic nlọghachi.

Insulin-isophan: ntuziaka maka ojiji nke nkwusioru

Aha Latin: isoulinum insulinum
Koodu ATX: A10a
Arụ Ọrụ: insulin-genetic engineering isophane

Emeputa: Novo Nordisk, Denmark

Ọnọdụ ezumike n'aka ụlọ ahịa ọgwụ: Site na ndenye ọgwụ
Ọnọdụ nchekwa: t n'ime ogo 2-8
Bọchị mmebi: Afọ 2

A na - eji insulin isveran injinini mee ihe maka ịgwọ ọnọdụ metụtara njikọta nke hormone nke anụ ahụ nke ọma site na ngwa insulin. Enweghị ọgwụ ọ bụla nwere aha a na ere, ebe ọ bụ na nke a bụ ụdị nke ihe na-arụ ọrụ, mana enwere analogues. Ihe atụ doro anya nke ụdị ihe dị na ire bụ rinsulin.

Isofan insulin: enwere m ike iji ọgwụ ndị ọzọ

Na-abawanye mmetụta hypoglycemic (normalization nke shuga ọbara) Isofan symbiosis na:

Sulfonamides,
Chloroquinine
ACE inhibitors / MAO / carbon anhydrase,
Ethanol
Mebendazole,
Pụtara nke bụ akụkụ nke otu nwere steroid anabolic,
Fenfluramine
Ọgwụ Tetracycline
Clofibrate
Ọgwụ nke theophylline otu.

A na-ebelata hypoglycemic mmetụta (na-ebutelata shuga n'ọbara nkịtị) n'ihi symbiosis nke Isofan nwere ọgwụ ndị dị otú a:

Somatropin
Epinephrine
Ihe mgbochi
Epinephrine
Phenytoin
Ndị na-emegide Calcium.

Obara shuga dị n'ọbara na-ebelata n'ihi symbiosis nke insulin Isofan nwere thiazide na loop diuretics, yana BMCC, yana homonụ thyroid, sympathomimetics, Klondin, Danazole, sulfinpyrazone. Morphine, wii wii, mmanya na nicotine belata shuga ọbara. Ndị ọrịa nwere ọrịa shuga ekwesịghị ị drinkụ ma ọ bụ na-a smokeụ sịga.

Na mgbakwunye na nhazi nke ọgwụ adịghị mma na Isofan, ihe ndị dị ka nwere ike ịkpalite hypoglycemia yana:

N'ịbanye na ọgwụ ọzọ na -eme ka ọ̀kwa shuga dị,
Ọrịa shuga na-agbọpụta
Ọrịa afọ ọria mamịrị
Mmụba anụ ahụ ibu
Ọrịa na-ebelata mkpa insulin (pituitary, hypothyroidism, imeju imeju, ọdịda akụrụ),
Mgbe onye ọrịa ahụ erighị nri n'oge,
Sitegbanwe nbanye saịtị.

Ọgwụ ezighi ezi ma ọ bụ ogologo oge n'etiti injections nwere ike ibute ọrịa hyperglycemia (ọkachasị n'ọnọdụ nke ụdị shuga 1). Ọ bụrụ na emezighị ọgwụgwọ ahụ n'oge, onye ọrịa ahụ nwere ike ịdaba na ketoacidotic coma.

Onye ọrịa na-a usesụ ọgwụ a torola afọ iri isii, ma ọ bụdị nke ukwuu nke na-arụ ọrụ nke thyroid gland, akụrụ, imeju, ọ dị mkpa ịkpọtụrụ dibịa bekee banyere usoro ịulinụ ọgwụ insulin Isofan. E kwesịrị ime otu usoro ahụ ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa hypopituitarism ma ọ bụ ọrịa Addison.

Etu esi edozi: ntuziaka pụrụ iche

Tupu ị takeụọ ọgwụ ahụ na sirinji, lelee ma ihe ngwọta ya dị urukpuru. O kwesịrị ịbụ uzo. Ọ bụrụ na flakes, ahụ ndị si mba ọzọ apụtawo, ihe ngwọta aghọwo urukpuru, mmiri amalitela, enweghị ike iji ọgwụ ahụ.

Okpomọkụ dị iche iche nke ọgwụ a na-ahụ maka ụlọ kwesịrị ịbụ okpomoku ụlọ. Ọ bụrụ na ị nwere oge oyi ma ọ bụ karịa na ọrịa ọ bụla ọzọ na-efe efe, ị kwesịrị ịkpọtụrụ dọkịta gị banyere dose ahụ. Mgbe ị na-edochi ọgwụ, nke a kwesịrị ime n'okpuru nlekọta dọkịta, ọ bụ ihe amamihe dị na ya ịga ụlọ ọgwụ.

Ime ime, lactation na insulin Isofan

Womenmụ nwanyị dị ime nke nwere ọrịa shuga nwere ike were insulin Isofan, ọ gaghị eru nwa ebu n’afọ site na Plasenta. Can nwere ike iji ya na ndị nne na-enye nwa ara, na-amanye ịnwe ọrịa a. Ọ dị mkpa ịmara na n’oge afọ ime n’oge nke mbụ, mkpa maka insulin na-ebelata, n’oge nke abụọ na nke atọ na-abawanye.

Ihe ngosi maka ojiji

Ihe kachasị gosipụtara bụ ọgwụgwọ nke ọrịa shuga 1, mana n'ọnọdụ ụfọdụ, enwere ike ịkọwa ya na ọnụnọ ọrịa na-enweghị insulin. Aha ahia ọ bụla maka isophane dabara adaba maka ọgwụgwọ nke onye na-anaghị a hyụ ọgwụ hypoglycemic n'ihi nkwụsị zuru oke ma ọ bụ nke ele mmadụ anya n'ihu. Ọ dịkarịghị, a na-eji ọgwụ eme ihe n’ebe ụmụ nwanyị dị ime nke nwere ụdị shuga nke abụọ.

Ngwakọta na ịhapụ ụdị

Ngwunye 1 ml nwere mejupụtara 100 nkeji nke ihe na-arụ ọrụ arụ ọrụ. Ihe inyeaka - protamine sulfate, mmiri na-enweghị atụ maka injections, crystalline phenol, sodium dihydrate phosphate, glycerol, metacresol.

Nkwụsịtụ maka ntụtụ, transperent. Otu karama nwere 3 ml nke ihe ahu. Na otu ngwugwu enwere 5 katridges ma ọ bụ na-ere ya n'otu karama ozugbo ọgwụ ọgwụ 10 ml.

Ngwongwo na-agwọ ọrịa

Isofan insulin bụ nkezi oge ọrụ nke onye na-ahụ maka hypoglycemic, nke emere site na iji teknụzụ DNA recombinant.

Mgbe nchịkwa subcutaneous gasịrị, homonụ nke endogenous na-ekekọta na insulin receptor complex, na-ebute njikọ nke ọtụtụ enzyme ogige - hexokinase, pyruvate kinase na ndị ọzọ.

Ekele maka ihe ewepụtara site na mpụta, oghere intracellular nke glucose na-abawanye, n'ihi nke ya na anụ ahụ na-anabata ya nke ukwuu, na -ebelata ọnụego shuga nke imeju na-ebelata nke ukwuu. N'iji ya mee ihe ugboro ugboro, ọgwụ ahụ na-akpali usoro nke lipogenesis, glycogenogenesis na proteinogenesis.

Ogologo oge nke ihe na ọnụego mmalite nke mmetụta na ndị mmadụ dị iche iche na-adabere n'ọtụtụ ihe, ọkachasị na usoro nke usoro metabolic. Kedu ihe ọ pụtara - usoro a bụ nke onwe ya.

Na nkezi, ebe ọ bụ nke a bụ homonụ nke usoro ọsọ ọrụ, mmalite nke mmetụta ahụ na-etolite n'ime otu awa na ọkara site na mgbe nchịkwa subcutaneous.

Ogologo oge nke mmetụta ahụ bụ awa 24, ntinye uche kachasị elu na-apụta n'ime awa 4-12.

A na-etinye ọgwụ ahụ n'ụzọ na-adịghị agbanwe agbanwe, a na-ahụkarị site na akụrụ, ogo nke nsonaazụ ahụ na-adabere ozugbo na saịtị ịgba agba (afọ, ogwe aka ma ọ bụ apata). Ọgwụ anaghị agafe ihe mgbochi placental ma banye n’ime mmiri ara, yabụ enyere ya ohere ime ndị nne na-amụ nwa.

Ofzọ nke ngwa

Ọnụ ego otu ọgwụ na Russia bụ 1075 rubles kwa otu.

Isi igbaji n’abia, otu ugboro n’ụbọchị, n’ebe dị iche iche. Ogologo oge nke inje n'otu ebe ekwesịghị ịfe karịa oge 1 kwa ọnwa, ya mere a na-agbanwe ebe nchịkwa nke ọgwụ n'oge ọ bụla.

Tupu ojiji a na-eme ampoules ahụ n'ọbụ aka.

Ntụziaka maka ịgba ntụtụ - ọgwụgwọ sterilaiz, a na-etinye ọdụ n'okpuru ala n'okpuru akụkụ 45 diges n'ime ogige gbara agba, mgbe ahụ ebe ahụ na-ekpochasị nke ọma. A na-ahọrọ dos ndị dọkịta iche iche.

N’oge ime ime na inye nwa ara

Anakwere ọgwụ ahụ ka o jiri mee ihe n’oge ndị a.

Ntuziaka na mgbochi

Ndị a gụnyere: anabataghị otu ihe arụ ọrụ na shuga dị ala n'otu oge.

Mkparịta ụka ọgwụ ọjọọ

Belata nsonaazụ nke ọgwụ ahụ: sisitemu glucocorticoids, mgbochi afọ, estradiol na progesterone, steroid anabolic, diuretics, antidepressants, homonụ thyroid.

Mmụba arụmọrụ: mmanya, salicylates, sulfonamides na beta-blockers, MAO inhibitors.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Hypoglycemia ma ọ bụ lipodystrophy ga-ekwe omume ma ọ bụrụ na agbasoghị iwu maka ịgba ntụtụ na usoro ọgwụ enyere. Mmetụta ndị na-adịghị ala ala na-emetụta ụdị nke mmeghachi omume nfụkasị, mkpụmkpụ ume, mbelata ọbara mgbali elu, hyperhidrosis na tachycardia.

N'ihe banyere oke ị ,ụbiga mmanya ókè, akara ọdịnala nke shuga dị ala na-apụta: mmetụta agụụ, adịghị ike, mfu nke iwe, ọgbụgba, ọsụsọ, agụụ iri nri ụtọ, n'ihe isi ike - coma. A na-akwụsị ihe mgbaàmà ntakịrị site na ịnweta carbohydrates ngwa ngwa, ndị na-ajụ - na injero dextrose ma ọ bụ glucose. Ọnọdụ siri ike chọrọ maka ndị dọkịta n'ụlọ ka ọ kpọọ ngwa ngwa.

Rinsulin PNH

Geropharm-bio LLC, Russia

Nkezi ego na Russia - 1000 rubles kwa ngwugwu.

Rinosulin bu analog zuru oke ma mejuputara insulin nke obere oge. Drugdị ọgwụ a dị mma n'ihi na ọ chọghị nchịkwa subcutaneous ugboro ugboro.

Uru:

Irè
Mmepụta Russia.

Cons:

Ọ bụghị dị ọnụ ala
Nsonaazụ ndị enwere ike.

Humulin NPH

Eli Lilly East, Switzerland

Nkezi ọnụahịa na Russia - 17 rubles.

Humulin NPH bụ analog nke ogo ekpughepụru ụzọ.

Uru:

Ebere ọnụ ala
Iyi iji ya.

Cons:

Enwere mmetụta ndị ọ na-akpata
Odighi nma maka onye obula.

Ihe omuma banyere Biosulin N na Pharmacy.ru

I chebe 104,00 rub.

maka otu 1 - 183,00 ite.

I chebe 49,00 rub.

maka otu 1 - 438,00 rub.

I chebe 99,00 rub.

maka otu 1 - 256,00 rub.

Pharmstandard-Ufa Vitamin Plant, Ọrịa Shuga nke JSC Russia

Ọrịa hypoglycemic, insulin na-arụ ọrụ.

Dị Mwepụta

5 ml - karama nke iko na-enweghị ụcha (1) - ngwugwu. 5 ml - karama nke iko na-enweghị ụcha (2) - ngwungwu ngwakọ (1) - ngwugwu. 5 ml - flasks nke glassless glass (3) - blister packets Nkwụsị nke nchịkwa subcutaneous nke 100 IU / ml - 3 ml nke nkwadebe ahụ n'ime iko na-anọpụ iche nke iko, na-ejikọtara ya na okpo jikọtara ọnụ, maka iji ya na Biomat Pen-efeteere ya maka nchịkwa subcutaneous 100 M / ml - 3 ml nke ọgwụ na a katrij nke iko na-anọpụ iche na-enweghị ụcha, ejiri okpu ejikọtara ọnụ. A na-etinye bọọdụ ahụ na mkpịsị mkpụrụ mkpịsị mkpụrụ nke biomatikPen maka otu oge. Na sirinji 5 Biomatikpen abụọ eji naanị cartridges na ngwugwu.

Nkọwa nke ụdị usoro onunu ogwu

Nkwụsịtụ ọcha. Mgbe ị kwụ, nkwusioru ahụ ga-adị, na-akpụ ụrọ. Onye kachasị elu bụ ihe doro anya, enweghị agba ma ọ bụ nke enweghị agba. A na - eji nwayọ nwayọ were weghachite ihe omume. Nkwụsị maka nchịkwa s / c nke agba ọcha, mgbe ọ na-eguzo ọtọ, nkwusioru ahụ na-edozi, na-akpụ ụzụ ọcha. Onye kachasị elu bụ ihe doro anya, enweghị agba ma ọ bụ nke enweghị agba. A na - eji nwayọ nwayọ were weghachite ihe omume.

Mlọ ọgwụ

Mwepu izuzu ezuzu na nmalite mmetụta insulin na-esite na ntanetị ara (afọ, afọ, isi), dose (olu insulin insulin), na ntinye insulin na nkwadebe.

A na-ekesasị ya na anụ ahụ na - ekwekọghị. Ọ dịghị agafe ihe mgbochi placental ma agbanyeghị na mmiri ara ara. Metabolism bibiri insulinase tumadi na imeju na akụrụ.

Egosiputa mmamiri n’ime mmamiri - 30-80%.

Ọnọdụ pụrụ iche

Cangaghị enwe ike iji ọgwụ biosulin® N ma ọ bụrụ na, mgbe ịma jijiji gasịrị, nkwusioru ahụ anaghị acha ọcha ma yikwa igwe ojii. Na-emegide usoro ịgwọ ọrịa insulin, ọ dị mkpa ịdị na-achọpụta ọ̀tụ̀tụ̀ glucose ọ̀tụ̀tụ̀ ọbara mgbe niile.

Na mgbakwunye na insulin ị insụbiga mmanya ókè, ihe kpatara hypoglycemia nwere ike ịgụnye iji ọgwụ dochie anya, nri nri, vomiting, afọ ọsịsa, mmụba anụ ahụ, ọrịa na-ebelata mkpa insulin (ọrụ imeju na akụrụ, hypofunction nke adrenal cortex, pituitary ma ọ bụ thyroid gland), mgbanwe nke nsị, na na mmekorita ya na ogwu ndi ozo.

Usoro usoro ịsingụ ọgwụ na-adịghị mma ma ọ bụ ihe mgbochi n'ime nchịkwa insulin, karịsịa na ndị ọrịa nwere ụdị ọrịa shuga 1 nke ọrịa mellitus, nwere ike ibute hyperglycemia. Ọtụtụ mgbe, mgbaàmà mbụ nke hyperglycemia na-amalite nwayọọ nwayọọ karịa ọtụtụ awa ma ọ bụ ụbọchị.

Ndị a gụnyere akpịrị ịkpọ nkụ, mmamịrị nke ukwuu, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, ọbara ọbara na ajị anụ, akpịrị ịkpọ nkụ, agụụ, agụụ nke acetone na ikuku nwere oke. Ọ bụrụ na agwọtaghị ya, hyperglycemia n'ụdị shuga 1 nwere ike ibute mmepe nke ọrịa ketoacidosis na-eyi ndụ egwu.

Ekwesịrị idozi ọnụọgụ insulin maka arụmọrụ thyroid, ọrịa Addison, hypopituitarism, imeju na / ma ọ bụ ọrụ akụrụ, yana ọrịa mellitus n'ime ndị gbara afọ 65. Ọ dịkwa mkpa iji dozie insulin nke insulin ma ọ bụrụ na onye ọrịa ahụ na-eme ka mmega ahụ sie ike ma ọ bụ gbanwee ụdị nri a na-emebu.

Ọrịa concoitant (ọkachasị nje) na ọnọdụ ọnya jikọtara ọnụ na-amụba mkpa nke insulin. Ọkpụkpụ site na ụdị insulin na nke ọzọ ga-ebufe n'okpuru ịchịkwa ọkwa glucose ọbara. Ọgwụ a na-ebelata mmanya nnabata.

N'ihi na enwere ike ịda mmiri na ụfọdụ catheters, a naghị atụ aro iji ọgwụ ahụ na nfuli insulin.

Mmetụta ikike ịnya ụgbọ ala na usoro njikwa n’oge nchịkwa insulin mbụ, mgbanwe nke ụdị ya, ma ọ bụ nwee mmetụta dị egwu anụ ahụ ma ọ bụ nke uche, enwere ike belata ike ịkwọ ụgbọala ma ọ bụ jikwaa usoro dị iche iche, yana itinye aka na ihe omume ndị ọzọ dị ize ndụ nke chọrọ mmụba. Nlebara anya na ọsọ nke psychomotor mmeghachi omume Usoro ntụtụ mgbe ị na-eji insulin na katriji Cartridge yana ọgwụ Biosulin N bụ nke ezubere. maka iji ya na mkpịsị mkpụrụ osisi BiomatikPen. E kwesịrị ịdọ onye ọrịa ọdụ banyere mkpa ọ dị ịgbasochi ntuziaka na ntuziaka maka iji mkpụrụ akwụkwọ sirinji maka inye insulin. Tupu ojiji, gbaa mbọ hụ na enweghị mmebi (dịka ọmụmaatụ, cracks) na katriiki yana Biosulin® N. Ejila katriiki ma ọ bụrụ na enwere mmebi ọhụhụ ọ bụla. Ejila Biosulin® N ma ọ bụrụ na, mgbe ị na-agwakọta ọdịnaya nke kadi ahụ dabere na ntuziaka maka ojiji a, insulin anaghị acha ọcha na igwe ojii. Ejila Biosulin N ma ọ bụrụ na enwere flakes mgbe agwakọchara. Ejila biosulin N ma ọ bụrụ na ntụpọ ọcha siri ike na-agbado ala ma ọ bụ mgbidi nke katriiki, na -emepụta “nfuli ifuru”. Mgbe etinyere katriati n’ime mkpịsị sirinji, ị ga-ahụrịrị ibe ọcha na windo nke ihe eji klọọkụ. Tupu ịdebe katriki na pen sirinji, tụgharịa katriza elu na ala ka bọọlụ ahụ wee na-aga site na nsọtụ ruo na njedebe nke katrij. Ekwesịrị imeghachi usoro a opekata mpe 10 ruo mgbe mmiri mmiri niile ga-acha ọcha ma kpuchie igwe ojii. Ozugbo nke a gasịrị, ọgwụ ntụtụ dị mkpa. Ọ bụrụ na katriiki ahụ abanyelarị n’ime mkpụrụ edemede sirinji, ị ga-atụgharị ya na katriiki ahụ n’ime ma gbadaa ala ugboro iri. Ekwesiri imeghari usoro a tupu ntụtụ ọ bụla. Mgbe a gbasịrị ya, agịga kwesịrị ịdị n’okpuru anụ ahụ ma ọ dịkarịa ala 6 sekọnd. Debe bọtịnụ ahụ ruo mgbe a kpochapụrụ agịga ahụ n'okpuru akpụkpọ ahụ, wee si otú a hụ na usoro nchịkwa kwesịrị ekwesị na ohere nke ọbara ma ọ bụ lymph ịbanye na agịga ma ọ bụ klọọkụ insulin. A na-ezube katọn ahụ ọgwụ ọgwụ Biosulin N naanị maka ojiji nkeonwe naanị ya ekwesịghị iju. Inzọ Ọgwụ Isi • Site na iji mkpịsị aka abụọ, kpokọta akpụkpọ anụ, tinye agịga ahụ n'okpuru isi nke mkpanaka ahụ n'ihe dịka 45 Celsius, ma tinye insulin n'okpuru anụahụ. • Mgbe a gbasịrị ya, agịga kwesịrị ịdị n’akpụkpọ ahụ ọ dịkarịa ala 6 sekọnd iji hụ na etinye insulin ahụ kpamkpam. • Ọ bụrụ na ọbara apụta na ebe a gbanye ọgwụ were agịga, jiri nwayọ kpochaa ebe a na-agbanye ya na mmiri nwere ọgwụ mgbochi (dịka mmanya). • Ọ dị mkpa ịgbanwe saịtị ntụtụ.

insulin-isophan (injinịa mmadụ) 100 IU Nlekọta: zinc oxide, sodium hydrogen phosphate, protamine sulfate, metacresol, crystalline phenol, glycerol, mmiri d / i.

Nsonaazụ Biosulin N

Site n'akụkụ nke metabolism: ọnọdụ hypoglycemic (pallor nke anụ ahụ, ịsụsọ nke ukwuu, mmetụta nke palpitations, jijiji, agụụ, oke iwe, paresthesia na ọnụ, isi ọwụwa). Nnukwu hypoglycemia siri ike nwere ike iduga mmepe nke hypoglycemic coma. Mmeghachi omume nfụkasị: na - adịkarịghị - ọnya anụ ahụ, ụbụrụ Quincke, n'ọnọdụ ụfọdụ - ujo anafilactic. Mmeghachi omume mpaghara: hyperemia, ọria na itching na ntụtụ ahụ, yana iji ogologo oge - lipodystrophy na saịtị ahụ. Ndị ọzọ: edema, njehie na - ezighi ezi mmebi (oge ụfọdụ na mmalite ọgwụgwọ).

Mkparịta ụka ọgwụ ọjọọ

E nwere ọtụtụ ọgwụ na-emetụta mkpa maka insulin.

Mmetụta hypoglycemic nke insulin na-eme ka ọ dị mma site na ọnụ ọgwụ hypoglycemic ọgwụ, ndị na-egbochi MAO, ndị na-adịghị ahọrọ beta-blockers, ACE inhibitors, sulfanilamides, anabolic steroid, carbonic anhydrase inhibitors, bromocriptine, octreotide, tetracyclines, kefiloflindofilflallollinkol kinkolilimin, klalline klallinkoline, klalline, klalline, klalline, nkwadebe nwere ethanol. Mmetụta hypoglycemic nke insulin na-ebelata site na mgbochi afọ, corticosteroids, homonụ thyroid, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, calcium channel blockers, diazoxide, morphine, not, not.N'okpuru mmetụta nke reserpine na salicylates, ma ike na-agwụ ike ma na-abawanye na ọrụ ọgwụ a ga-ekwe omume

Ahịa maka Biosulin N n'obodo ndị ọzọ

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Isi nnyefe niile na Moscow - ụlọ ahịa 696

Bọchị nyocha: Eprel 2, 2016

Gụọ nyocha niile Nyochaa: Bondareva Margarita

Bọchị ntụleghachi: Ọgọst 1, 2016

Bọchị ntụleghachi: Ọgọst 19, 2016

Bọchị nyocha: Septemba 15, 2016

Bọchị ntụleghachi: February 18, 2017

Isofan mepụtara ọgwụ mmadụ site n'aka mmadụ: iji ya na ọnụ ahịa ọgwụ ahụ

Isofan bụ insulin injin nke ukwuu nụchara anụcha, nke a na-eji maka ọgwụgwọ nke ndị ọrịa nwere ọrịa shuga.

A na-ahụta insulin mmadụ, nke enwetara na mkpụrụ ndụ ihe nketa site na iji teknụzụ DNA recombinant, bụ ọgwụ ogologo oge.

N’ụlọ ahịa ebe a na-ere ọgwụ, a na-ere ya n’ụdị nkwusioru ejiri ọgwụ ịgba agba agba n’ahụ. Ọnụahịa ahụ dabere na usoro onunu ogwu, onye nrụpụta ma dịgasị iche site na 500 ruo 1000 rubles.

Ọgwụ Farmacology

Isofan - insulin, nwere mmetụta hypoglycemic. Ọ dị na nsọtụ pụrụ iche nke sel sel cytoplasmic nke dị na mpụta, n'ihi nke mepụtara usoro nnabata insulin. Ọ na - enyere aka ịgbalite usoro intracellular.

N'ihi eziokwu ahụ bụ na ngagharị nke glucose n'ime sel na-abawanye, ego ya na ọbara na-ebelata. A na-enweta mmetụta yiri nke ahụ site na ibelata ọnụego glucose site na imeju na ịba ụba nnweta site na anụ ahụ.

Ọgwụ a na - arụ ọrụ ogologo oge n'ihi ọsọ nke mmiri, nke na - emetụta ọtụtụ ihe: otu esi etinye insulin (enwere ike itinye ya n'afọ, apata ma ọ bụ isi), usoro nchịkwa, usoro onunu ogwu.

Mgbe iwebata insulin jiji mkpụrụ ndụ ihe mejupụtara agbanye n'okpuru anụ ahụ na ntụtụ, ọ na-eme ka otu elekere na ọkara gachara. Ọgwụ kachasị dị irè site na 4 ruo elekere nke 12, na-arụ ọrụ n'oge ụbọchị.

Enwere ike ịme ihe ndị a na njirimara ndị dị mkpa nke Isofan: ọ naghị etinye uche na mmiri ara nne. Nkesa na anụ ahụ ezighi ezi. Anaghị agafe Plasenta. Site na 30 ruo 80% bụ akụrụ.

Ntụziaka maka ojiji

Ntụziaka maka ojiji gosipụtara ụdị ọrịa ọrịa insulin na - eji emepụta mkpụrụ ndụ - eji agwọ ọrịa shuga na - akpata ọrịa shuga mellitus. A na-eme ọgwụgwọ n'ọnọdụ a n'oge ndụ niile. N'okwu a, ọ dị mkpa ịgbaso usoro injection. Na mgbakwunye, a na-eji Isofan eme ihe maka ụdị 1 na ụdị shuga 2.

Dọkịta nwere ike inye gị ọgwụ ahụ ma ọ bụrụ na enwereghị nsonaazụ site na ọgwụ nwere ike ịbelata shuga. Emezie insulin ka ọ bụrụ ọgwụgwọ agwakọta.

Mmụba na shuga ọbara nwekwara ike ịbụ nsonaazụ nke nsogbu, dịka ọmụmaatụ, mgbe ọwachara ahụ. N'okwu a, enwere ike ịkọ ọgwụ insulin ka ọ bụrụ ọgwụgwọ dị mgbagwoju anya. Edere ya ọgwụ maka ụmụ nwanyị dị ime nke nwere ọrịa shuga.

A na-eji Isofan mee ihe naanị maka ụdị 1 na ụdị 2 ọrịa shuga!

A na-egbochi ọgwụ a na ndị ọrịa na-enwekarị mmeghachi omume nfụkasị yana inwe hypoglycemia.

Mmetụta mmetụta

Isi mmetụta dị na ị Iụ Isofan bụ:

Mmetụta ọjọọ na metabolism metabolism. E gosipụtara nke a n'ụdị pallor nke anụ ahụ, ịsụ ngọngọ na-asọ asọ, nkụchi obi ngwa ngwa, ọdịdị ahụ na-ama jijiji, mmadụ na-achọkarị iri nri, na-enwe ahụmịhe ụjọ, isi ọwụwa ugboro ugboro.
Allergy gosipụtara site na nsị anụ ahụ, edere nke Quincke. N'ọnọdụ ndị a na-adịghị ahụkebe, ọgwụ ahụ na-akpata akpata ụjọ akpata anaphylactic.
O nwere ike iputa.
Mgbe ogwu ogbugba, itching ma ọ bụ ọria, ọnya nwere ike ime. Ọ bụrụ na ọgwụgwọ ahụ na-adịgide ogologo oge, etolite lipodystrophy guzobere.

N'akụkụ a, na mmalite ọgwụgwọ, enwere ike ịme ọgwụ insulin naanị mgbe ọ họpụtara dọkịta ma n'okpuru nlekọta ya.

Dose doseụbiga ihe ókè

N'ihe banyere iwebata ọgwụ ịba ụba, onye ọrịa ahụ nwere ike ịnweta ihe ịrịba ama nke hypoglycemia. N'okwu a, ịkwesịrị iri otu shuga ma ọ bụ nri nwere carbohydrates. Ọ nwere ike ịbụ kuki, ihe ọ fruitụ fruitụ mkpụrụ osisi, sweets.

Mata oke Isofan nwere ike ibute enweghị mmụọ. A na-atụ aro ka ịnye ọgwụ ntụtụ nke 40% dextrose. Enwere ike ijikwa Glucagon intramuscularly, intravenously ma ọ bụ subcutaneously.

Nchedo nchekwa

Mgbe ị na-eji Isofan, ekwesịrị iburu n'uche na ọ bụrụ na ịgbanye ọgwụ ahụ n'otu ebe, lipodystrophy nwere ike ịmalite. Iji gbochie ya, a na-atụ aro ịgbanwe ebe injection. Mgbe ị na-eme ọgwụ insulin, ị kwesịrị iji nlezianya nyochaa shuga ọbara gị.

A ga-enyocha ya nke ọma dabere na usoro nke dọkịta nyere. Ma ọ bụghị ya, hypoglycemia nwere ike ịmalite. Ọ nwere ike pụta site na nri ị na-eri n'oge na-adịghị. N'okwu a, mmadụ na-enwe mmetụta akpịrị ịkpọ nkụ, akpịrị na-akpọ nkụ, mgbe ọ na-awa ahụ, ahụike na-egosi ya, site na ọgbụgbọ, ruo mgbe ọ na-agbọ, agụụ, iku ume nke acetone n'ọnụ.

Ogwu a na-achịkwa kwesịrị ịbụ nke anụ ahụ ọ bụla, na-enyocha ya, na-enweghị okpuru mmiri na ala. Ọnụnọ ya na-egosi nsị nke insulin, n'ihi ya iji ọgwụ nwere ike ịdị ize ndụ nye onye ọrịa.

Isophan kwesịrị ịdị n ’ụlọ okpomọkụ mgbe a na-ahazi ya. Site na ọrịa na-efe efe nwetara n'ihi nsị thyroid, hypopituitarism, usoro nke ọgwụ ịchọrọ kwesịrị ka ọ gbanwee.

Dabere na nke Isofan, dọkịta depụtara ya mgbe enweghị ọgwụ ọ bụla iji ọgwụ belata shuga.

Mkpakọrịta

Ntuziaka maka iji ọgwụ ahụ na-akọwa n'ụzọ zuru ezu njirimara ọgwụ ahụ na nuzu nke iji ya.

Injinia Isofan mmadụ nwere ike rụọ ọrụ ma ọ bụrụ na a areụọ ọgwụ ndị a n'otu oge:

Hypoglycemic ọnụnọ nke mmadụ.
MAO na ACE inhibitors, carbon anhydrase.
Sulfonamides.
Anabolikov.
Tetracyclines.
Ọgwụ nwere ethanol.

Idị nke Isofan na-adalata mgbe ejiri ya: mgbochi ogwu a na-ede ede, ọgwụ glucocorticoid, homonụ thyroid, antidepressants, morphine. Ọ bụrụ na-agaghị ekwe omume ịkagbu ọgwụ na-emetụta ihe nke insulin, ọ dị mkpa ịdọ ndị dọkịta na-aga ya aka banyere nke a.

Ọgwụ yiri ya

Ndị ọrịa shuga nwere mmasị n’ajụjụ nke ihe a ga-eji dochie insulin. A na-atụ aro ka iji ọgwụ analogues ndị Isofan na-eso maka ọgwụgwọ: Humulin (NPH), Protafan-NM, Protafan-NM Penfill, Insumal, Actrafan.

Tupu ị gbanwee Isofan ka analog, ọ dị mkpa ịkpọtụrụ dọkịta gị. Usoro ọgwụgwọ insulin bụ ọgwụgwọ siri ike. Ọ chọrọ ịdọ aka ná ntị nke onye ọrịa na ịlele dọkịta.

Ọrịa shuga mellitus bụ nnukwu ọrịa, nke, ọ dị mwute ikwu na enweghị ike iwepụ ya kpamkpam. Dị ka ị maara, megide azụ nke ọrịa, enwere mmebi nke ịba uru nke homonụ na akwara nke pancreas. Ọtụtụ mgbe, a na-enye ndị ọrịa ọgwụ Isofan ọgwụ insulin. Ihe a na - achịkwa ọkwa shuga dị n’ọbara, na - arụ ọrụ arụ ọrụ niile na arụ ọrụ.

N'ezie, ndị ọrịa nwere mmasị na ozi ọ bụla ọzọ banyere ọgwụ. Kedụ ka Isofan na-emepụta sịntetik sịntetik gbara anụahụ? Ntuziaka, contraindications, nsogbu enwere ike n'oge ọgwụgwọ bụ isi ihe dị mkpa a ga-atụle n'isiokwu ahụ.

Mpempe mwepụta

Ọ bụghị ihe nzuzo na ọrịa shuga bụ ọrịa a na-ahụkarị ma dị ize ndụ nke chọrọ iji ọgwụ dị iche iche, gụnyere insulin.

"Isofan" bụ aha ahia ọgwụ, nke bụ ngwakọta edozila nke homonụ semisynthetic. A na-emepụta ọgwụ ọgwụ n'ụdị ihe ngwọta maka nchịkwa subcutaneous.

A na-ere ọgwụ ahụ na karama iko nke 10 ml na usoro onunu ogwu nke 40 IU / ml. Iji kwadebe osisa ahụ, a na-eji mmiri dị ọcha maka ntụtụ.

Ọ bụrụ na ọgwụ ndị ọzọ nwere otu ihe mejupụtara na akụrụngwa insulin Isofan. Mmechi ya bu “Insuman”, “Protafan” na “Himulin”. Ọ bara uru ikwu ozugbo na ọgwụ ndị dị otú ahụ na-enye ndị mmadụ ọgwụ naanị ma ọ bụ ndị endocrinologist na-enye ha.

Kedụ akụrụngwa ọgwụ a nwere?

Isofan insulin bu homonụ nke mmiri na - eme nke nwere ihe ala dị ka ihe mmadụre na-emepụta. Ọgwụ na-ebelata oke glucose n'ọbara site na ịkwalite usoro nke lipogenesis na gluconeogenesis.

Homonụ sịntetik na-emekọ ihe na insulin na-anabata ndị mejupụtara sel, na-eme ka usoro metabolic dị n’ime sel ahụ rụọ ọrụ. Mgbe ị theụsịrị ọgwụ ahụ, enwere mmegharị nke njikọ nke ụfọdụ enzymes, gụnyere glycogen synthetases, pyruvate kinases na hexokinases.

Enwere ike ichoputa utịp ahụ awa 1,5.5 mgbe iwebata usoro a. Dabere na nha na njiri nke ahụ onye ọrịa, a na-ahụ ọrụ kachasị nke insulin sịntetik awa 4-12 mgbe nchịkwa gasịrị. Mmetụta ahụ dị site na 11 ruo 24 awa.

Isi ihe ngosi maka ojiji

A na - eji ọgwụ "insulin-Isofan" mee ihe maka ọrịa shuga mellitus nke ụdị nke abụọ (ụdị ịdabere insulin). A na-ejikwa ya maka ọgwụgwọ insulin nke nwa oge. Mgbe ụfọdụ, a na-achọ ọgwụgwọ maka ụdị ọrịa shuga 1. Dịka ọmụmaatụ, a na-atụ aro iwebata usoro maka ndị ọrịa n'ọnọdụ ebe ọgwụ na-ebunye shuga adịghị enye mmetụta achọrọ.

Iwebata insulin mmadụ chọrọ mgbe ụfọdụ usoro ịwa ahụ gasịrị. A na-ejikwa ọgwụ a maka ọrịa shuga mellitus (ụdị ọrịa a na-ebilite n'ime ụmụ nwanyị n'oge afọ ime). A na-atụ aro iwebata insulin nye ndị nne na - atụ anya ma ọ bụrụ na usoro ọgwụgwọ enweghị ike ọ chọrọ.

Ngwunye insulin na-eme ka "Isofan": ntuziaka maka ojiji

Site n'ọrịa shuga nke 2, ndị ọrịa chọrọ ọgwụgwọ ogologo ndụ. Dose, ego kwa ụbọchị, usoro nhazi - a na-ekpebi ihe ndị a site na ịga endocrinologist. Ọ dị mkpa ịgbaso ndụmọdụ niile nke ọkachamara. Enwere ụfọdụ iwu izugbe maka iji insulin-Isofan.

Ihe ngwọta a bụ naanị maka nchịkwa subcutaneous. N'ọnọdụ ndị na-adịghị ahụkebe, dọkịta nwere ike ịkwado inye ọgwụ ahụ intramuscularly. Amachibidoro inje intraven.
Enweghi ike inye ọgwụ ahụ n'otu ebe.
Ikwesiri ịkwanye karama ahụ ọtụtụ oge, wee dọpụta ego achọrọ nke ngwọta n'ime sirinji (ahọpụtara oke ahụ n'otu n'otu).
Ekwesịrị ịme ka ọgwụ ịgba ntụtụ ahụ ozugbo ejupụtachaa sirinji ahụ.

A na-echekwa vials na ngwọta ya na friji n'oge okpomọkụ nke ogo 2-8 Celsius. Tupu ị ghaa ọgwụ, ịchọrọ tụọ ọkwa nke glucose dị n'ọbara. N'ọnọdụ ọ bụla ị ga-eji ọgwụ ahụ ma ọ bụrụ na ịchọpụta ihe ngwọta igwe ojii, nhazi nke mgbidi dị na karama ahụ.

Enwere ọgwụ mgbochi ọ bụla?

Ọgwụ nwere ụfọdụ contraindications - data ndị a nwere ntuziaka maka ojiji. Edeghị "insulin-Isofan" maka ndị ọrịa nwere hypoglycemia.

Ihe mgbochi contraindines gụnyere insulinoma, yana hypersensitivity na mmiri ọgwụ.

Ọ dị mma ịmara na mgbe ụfọdụ ọbụna mgbanwe na saịtị ịgba ahụ nwere ike ibute mmeghachi ahụ nfụkasị na ọdịdị nke mmetụta ndị ọzọ.

Eleghị anya mmetụta

Ọgwụ a dị mkpa maka ndị ọrịa nwere ụdị ọrịa shuga na-akpata. Ka o sina dị, ọgwụgwọ metụtara ụfọdụ nsogbu. Mmebi iwu dị a canaa nwere ike ibute iji Isofan-Insulin mee ihe? Ntụziaka ahụ nwere ozi ndị a:

Ndepụta nke nsogbu ndị a na-ahụkarị nwere ike ịgụnye mmeghachi omume nfụkasị, nke a na-esonyere na nrịba ọnya na urticaria, mbelata ọbara mgbali elu, mmụba ahụ ọkụ na ọdịdị nke edema.
Ihe dị ize ndụ na ọgwụgwọ insulin bụ hypoglycemia, ọnọdụ a na-egosipụta mbelata nke shuga ọbara. Ihe mgbaàmà gụnyere pallor nke anụ ahụ, ọnya obi ngwa ngwa, nchekasị, nsogbu ihi ụra, mmetụta agụụ oge niile. A na-ejikọ ụdị mmebi a na usoro ọgwụgwọ ma ọ bụ na-agbasoghị ndụmọdụ dọkịta. N'okwu ndị kachasị sie ike, a na-amalite inwe hypoglycemic coma.
Treatmentmalite ọgwụgwọ na ụfọdụ ndị ọrịa metụtara nkwarụ anya. Ọ baghị uru ichegbu onwe gị banyere nke a, ebe ọ bụ na n'ọnọdụ ka ukwuu, mmetụta ndị dị otú ahụ na-akwụsị n'onwe ha.
Ndepụta nke nsogbu enwere ike ịnwe mmeghachi omume immunological, nke na-agafekwa ka ahụ ahụ na-emegharị ụdị insulin a.
Na mbido ị theụ ọgwụ ahụ, ọ ga-ekwe omume mmeghachi omume anụ ahụ, gụnyere redness na itching. Ha na-agafekwa onwe ha.
Nkpata nke oke ọgwụ ị tooụ ọgwụ ọjọọ buru ibu nwere nsogbu uche. Mgbakasị ahụ na-abawanye, nchekasị, mgbanwe omume, mmepe nke ịda mba kwuru.

Ọ dị mma ịghọta na ekwesịrị inye insulin insulin dịka usoro nke dọkịta si hazie. Imeghari ntụtụ ntụtụ na uto nke acid na-arịa ọrịa mamịrị.

N'ime ọgwụ ọgbara ọhụrụ, a na-eji insulins mmadụ na-eme ihe (obere oge na nke obere oge), analogues nke homonụ mmadụ, yana ngwakọta na-ejikwa ọkwa nchịkwa glucose. N'ezie, ahịa ọgwụ na-enye ọtụtụ ọgwụ na-enyere aka iwepụ ihe mgbaàmà nke ọrịa shuga oge ụfọdụ.

N'ime listi analogues nwere ike itinye ọgwụ dika “Actrafan”, “Biogulin”, “Diafan”. N'ọnọdụ ụfọdụ, a na-atụ aro ka ndị ọrịa mee nkwadebe "Protafan", "Humodar", "Pensulin". A na-ahụkwa insulin nke Bazal na Fereyn dị mma.

Ekwesiri ighota na homonụ ndi ahu bu ogwu di ezigbo ike, i gaghi eji ya onwe gi n’okwu obula. Naanị dọkịta nwere ike ịhọrọ analọg wee chọpụta dose ahụ.

Iji maa atụ, ọnụnọ nke opekata mpe mgbakwunye na ụfọdụ ndị ọrịa nwere ike ibute mmeghachi omume nfụkasị ahụ ruo ujo anacticlactic.

Ihe omuma ndi ozo banyere ogwu

Tupu ịmalite usoro ọgwụgwọ, ị ga-agwarịrị dọkịta gị banyere ọgwụ ị na-a .ụ. A na - eme ka ihe insulin sịntetik dịkwuo mma ma na - ewere ya na sulfonamides, adrogen na anabolic steroid, MAO inhibitors, ọgwụ mgbochi na - abụghị ọgwụ steroid.

A na-ekwupụta mmetụta hypoglycemic megide ndabere nke otu ọgwụ Isofan na ketoconazole, cyclophosphamide, quinine, chloroquinine, quinidine, na ọgwụ nwere lithium.

Site n'ụzọ, a naghị atụ aro ị drinkụ mmanya n'oge ọgwụgwọ, ebe ọ bụ na ethanol na-eme ka mmetụta insulin na-eme ka ọ dịkwuo ala.

Estrogens, mgbochi mkpị ọnụ, glucagon, heparin, homonụ thyroid na-ebelata ike nke ọgwụ. Enwere ike ikwu otu ihe ahụ banyere nicotine, wii wii, morphine, ụfọdụ diuretics (karịchaa, thiazide na loop), ọgwụ antidepressants tricyclic.

N'ọnọdụ ọ bụla, ekwesịrị ịghọta na na-enweghị ihe ọmụma dọkịta, ị nweghị ike ịgbanwe dose ma ọ bụ usoro nke insulin. Ekwesiri igosipụta mmekpa ahụ na-akawanye njọ ma na-emebi emebi na nnọchi anya endocrinologist.

Isofan insulin: ntuziaka maka ojiji na ọnụahịa ọgwụ

Ọgwụ insulin nwere agwa nnọchi, n'ihi na isi ọrụ ọgwụgwọ bụ imegwara ihe ndị na-adịghị mma na metabolism metabolism site na iwebata ọgwụ pụrụ iche n'okpuru anụ ahụ. Ọgwụ dị otú ahụ na-emetụta ahụ mmadụ na insulin nke sitere na pancreas mepụtara. N'okwu a, ọgwụgwọ ahụ zuru oke ma ọ bụ ele mmadụ anya n'ihu.

N'ime ọgwụ ndị a na-eji maka ọrịa shuga, otu n'ime ihe kachasị mma bụ insulin Isofan. Ọgwụ nwere insulin nke sitere na mkpụrụ ndụ ihe mmadụ jiri oge ọkara.

Ngwá ọrụ dị n'ụdị dị iche iche. A na-edozi ya n'ụzọ atọ - subcutaneously, intramuscularly na intravenously. Nke a na-enye onye ọrịa ohere ịhọrọ nhọrọ kachasị mma maka ịchịkwa ọkwa nke glycemia.