C peptides maka ọrịa shuga

Site na mmụba nke glucose ọbara, pancreas na-eme ka proinsulin ụmụ irighiri ihe na-eme, nke na-enye aka na mbibi ha na insulin na nsị amino acid, nke bụ C-peptide.

N'ihi ya, agịrị nke peptides na - apụta mgbe emepụtara insulin n'ime ahụ. Na elu ọdịnaya nke C-peptides n’ime ọbara, insulin na-arụ ọrụ n’ime ahụ.

Peptide nwetara aha "C" n'ihi na yinye ya bụ otu n'ụdị leta a. Na mbu, udiri insulin na-adi ka gburugburu.

N'ime ọrịa shuga mellitus ma ọ bụ ọrịa imeju, a na-eme nyocha maka C-peptides, n'ihi na mgbe akụkụ ahụ mepụtara, insulin na-agafere imeju, ebe ahụ na-edozi akụkụ ụfọdụ, na-abanye n'ọbara na-ezighi ezi. Ya mere, ọ gaghị ekwe omume ịchọpụta ego ole insulin rụpụtara.

Anyị na-enyekwa maka ịgụ: “A na-ekesa ọrịa shuga?”

Na usoro nchịkọta insulin, pancreas na - ewepụta ntọala izizi ya - preproinsulin. O nwere amino acid 110 jikọrọ ya na Peptide A, peptide L, B peptide na C peptide.

Otu obere akụkụ nke L-peptide na-ekewapụ na preproinsulin na etolite proinsulin, nke enzymes na-eme ka ọ rụọ ọrụ. Mgbe usoro a gasịrị, a na-ebipụ C-peptide, yana agbụ A na B jikọtara ọnụ site na akwa mbibi.

Ọ bụ ụdọ ndị a na àkwà mmiri ha bụ insulin homonụ.

A na-ahapụ insulin na C-peptide n'ime ọbara n'ụzọ kwekọrọ, nke a pụtara na site n'ọkwa nke ikpeazụ onye ahụ nwekwara ike ikpebi ọkwa insulin dị n'ọbara. Na mgbakwunye, C-peptide na-egosipụta ọnụego nke mmepụta insulin.

Ọkwa insulin na C-peptide n’ime ọbara na-adị iche mgbe niile. A kọwara eziokwu a site n'eziokwu ahụ bụ na insulin “dị ndụ” n'ime ọbara naanị maka nkeji 4, yana C-peptide ihe dịka nkeji iri abụọ. Ọ bụ ya mere ntinye nke C-peptide ji dị okpukpu ise karịa ọkwa insulin.

Peptide a na-ejikọ ọnụ (C-peptide) bụ akụkụ nke ụyọkọ peptide nke proinsulin, n'elu nsị nke insulin na-akpụ. Insulin na C-peptide bụ ngwaahịa ngwụcha nke mgbanwe nke proinsulin n'ime sel nke reat nke pancreatic isuore (pancreas) n'ihi ekpughe nke endoleptidase. N'okwu a, a na-ahapụ insulin na C-peptide n’ime eriri ọbara.

Ndụ ọkara na plasma nke C-peptide dị ogologo karịa nke insulin: na C-peptide - nkeji 20, na insulin - nkeji 4. Ọ bụ n'ihi nke a ka C-peptide dị n’ime ọbara ji ihe dị ka ugboro ise karịa insulin, ya mere, ihe nrịba nke C-peptide / insulin bụ 5: 1.

Nke a na-egosi nkwubi okwu na C-peptide bụ akara akara kwụsiri ike karịa nke insulin. Site na sistem okirikiri, imeju na-ewepụ insulin, yana C-peptide site na akụrụ.

Etechọpụta mkpokọta nke C-peptide n'ime ọbara na-eme ka o kwe omume ịkọwapụta ọrụ nsị nke mkpụrụ ndụ β-(mgbe a gbasasịrị ya na glucagon ma ọ bụ tolbutamide), ọkachasị ndị ọrịa mesoro insulin heterogene.

N’egwuregwu dị irè, a na-eji nchọpụta C-peptide chọpụta ihe na-akpata hypoglycemia. Dịka ọmụmaatụ, na ndị ọrịa nwere insulinoma, a na-achọpụta mmụba dị ukwuu nke mkpokọta C-peptide n'ime ọbara.

Iji gosipụta nchoputa a, a na-eme nnwale nke igbochi ụdị mkpụrụ ndụ ihe omimi nke C-peptide. N'ụtụtụ, a na-ewere ọbara site n'aka onye ọrịa ahụ ịchọpụta C-peptide, mgbe nke a gasịkwara insulin n'ọbara otu elekere na 0.1 U / kg ma werekwa ọbara ọzọ maka nyocha.

Ọ bụrụ na ọkwa nke C-peptide mgbe insulin infusion dara site na-erughị 50%, mmadụ ga-ekpebi maa ọkwa ọnụnọ insulin na-ezo n'ime onye ọrịa. Nnyocha nke C-peptide na-enye gị ohere inyocha nzuzo nke insulin megide ndabere nke iji insulin exogenous, na ọnụnọ nke autoantibodies na insulin.

C-peptide, n'ụzọ dị iche na insulin, anaghị emebe njikọta na ọgwụ mgbochi insulin (AT), nke na-eme ka o kwe omume ịchọpụta ọkwa insulin na-emetụta ndị ọrịa nwere ọrịa shuga site n'ọkwa ya. Knowingmara na ọgwụ insulin adịghị enwe ọgwụ C-peptide, site n’ọkwa ya n’ebe a na -eme ya ọbara, ọ ga-ekwe omume ịtụle ọrụ nke mkpụrụ ndụ reatcreatic in n’ime ndị ọrịa nwere ọria insulin.

Nnwale ọbara maka C-peptides na ọrịa shuga

Varidị C-peptide dị iche iche na-arụ ọrụ dị mkpa na nchọpụta nke ọrịa dị oke njọ. Usoro nke omume ha na nkwadebe kwesịrị ekwesị dịkwa mkpa iji nweta nsonaazụ ziri ezi na ebumnuche, site n'enyemaka nke usoro ọgwụgwọ zuru oke.

C-peptide: kedu ihe ọ bụ?

Iji chọpụta ọkwa nke glucose dị n’ọbara onye ọrịa, a na-eji ọbara venous eme ihe. Nsu ahụ na-eme tupu mgbe emechara, i.e. mgbe awa 2 gachara, mgbe mmadụ natara mgbanye glucose. Agbanyeghị, ọ dịkwa mkpa ịmata ọdịiche dị n'etiti ọrịa shuga na-adabere na ọrịa shuga na-abụghị insulin, na ebumnuche ndị a, a na-eme nnyocha na C-peptides.

C-peptide n'onwe ya adịghị arụ ọrụ nke ukwuu na ihe ndị dị ndụ, ụkpụrụ ya dị ala, mana ihe ngosi ya bụ ọnụego nke imepụta insulin. N’ezie, n’ime jumps dị iche iche na glucose, usoro nke proinsulin na-akụda n’ime insulin ma nweekwa otu C-peptide. Usoro nhazi nke ihe a na - aputa ihe n’ime sel.

Ihe ngosiputa maka nhọpụta ule ọbara maka C-peptide

C-peptide, n'ụzọ dị iche na insulin, anaghị emebe njikọta na ọgwụ mgbochi insulin (AT), nke na-eme ka o kwe omume ịchọpụta ọkwa insulin na-emetụta ndị ọrịa nwere ọrịa shuga site n'ọkwa ya. Mara na ọgwụ insulin enweghị ọgwụ C-peptide, enwere ike ịtụle arụmọrụ β-sel nke ndị ọrịa nwere ọrịa mellitus site n'ọkwa ya na ọbara. na-agwọ insulin.

C-peptide pụtara “ejikọ peptide”, sụgharịa ya na Bekee. Nke a bụ ihe na - egosi izochi insulin nke onwe gị. Ọ na-egosi ọkwa nke mkpụrụ ndụ beta pancreatic.

Mkpụrụ ndụ Beta na - ewepụta insulin n’ime akwara, ebe echekwara ya dịka proinsulin n’ụdị ụmụ irighiri ihe. N ’ụmụ irighiri ihe ndị a, dị ka ihe amino acid fọdụrụnụ, iberibe ihe ụfọdụ bụ nke a na-akpọ C-peptide.

Na mmụba nke glucose, ụmụ irighiri proinsulin na-agbadaru n'ime peptide na insulin. Nchikota di otua n’etiti obara na emekorita ibe ya. N'ihi ya, iwu bụ 5: 1.

Ọ bụ nyocha nke C-peptide na-enye anyị ohere ịghọta na nzuzo (mmepụta) nke insulin belatara, yana ikpebi ohere nke ọdịdị insulinoma, ya bụ, ọria.

A na-ahụta ọkwa dị elu nke ihe.

insulin na-arịa ọrịa shuga mellitus,
gbasara akwara
iji ọgwụ homonụ,
insulinoma
ọbara mgbali beta.

A gbadara ọkwa c-peptide bụ njiri mara maka:

shuga insulin na-akpata insulin na ọnọdụ hypoglycemic,
ọnọdụ nrụgide.

Kedu ihe nyocha dị mkpa maka?

Edere nyocha dị otú a n'ọnọdụ ụfọdụ:

na-enyo enyo ọrịa shuga nke ụdị dị iche iche,
na-enyo enyo cancer
na-ekpebi ọnụnọ / ọnụnọ ọnya ọnya dị iche iche,
na-enyo enyo nke nwanyi polycystic n'ime ụmụ nwanyị,
nyocha ọnụnọ / ọnụnọ echekwara akụkụ akụkụ akwara ahụ ka arụchara ọrụ,
nyocha nke steeti anụ ahụ na ndị na-eto eto nwere nsogbu maka oke ibu.

Ihe omumu ihe omumu nyere aka na C-peptide nwere ihe ndi di nkpa:

Nke mbu, nyocha di otua na enyere gi aka inyocha ogo insulin n’ime obara, obuna mgbe ogwu mgbochi autoimmune di n’ahu, nke n’eme na udiri oria m,
Nke abuo, ọkara ndu nke ihe a toro ogologo nke insulin, ya mere ihe ndi di otua g’esi no ike karie.
Nke atọ, nyocha a na-enyere aka ikpebi usoro insulin ọ bụla ọbụna na ọnụnọ nke homonụ na-akpụ akpụ.

A na-eme nyocha a mgbe nkwekọrịta kwekọrọ na endocrinologist ma ọ bụrụ na enwere enyo nke ọnụnọ nke ọrịa metabolic. Dịka iwu, a na-ese nnwale ọbara na afọ efu. Ọ kachasị mma ma ọ bụrụ na mmadụ erighị nri ọ bụla maka awa 6-8 tupu nyocha. Ọtụtụ ndị ọkachamara na-atụ aro ya n'ụtụtụ, mgbe onye ahụ tetara.

Mgbe itichara akwara, a na-anakọta ọbara achọrọ n'ime nnukwu efere pụrụ iche. N'ihe banyere hematomas mgbe nyocha nke ọrụ nyocha ahụ, a na-enye ndị na-ekpo ọkụ ọkụ ọkụ.

Ọbara na-agafere otu narị ihe ga-eme ka ọbara wee kewaa, ma ọ gafee. Mgbe nke a gasiri, usoro omumu amalite site na iji ihe ndi puru iche.

Atụmatụ nyocha

Nyocha C-peptide bụ mkpebi nke ọnụọgụ protein nke proinsulin n'ọbara ọbara site na iji usoro immunochemiluminescent.

Ihe nnwale: serum (nke anwara n’elu uto efu n’ututu (n’agbata awa nke 10-12). Tupu ịmalite nyocha ahụ, a na-atụ aro onye ọrịa ahụ ka ọ 200ụọ mmiri 200-300 ml. A na-enyocha ya ugboro abụọ n'ọnwa. Ormalkpụrụ a na-ahụkarị: n'ime ụmụ nwoke na ụmụ nwanyị: site na 5.74 ruo 60.3 nmol / l (na ọbara). Kpụrụ Ntuziaka:

ọbara ma ọ bụ plasma: 1.1-4.4 ng / ml (nkezi 1.96 ng / ml), 0.37-1.47 nmol / L (nkezi 0.65 nmol / L),
na mmamịrị mgbe awa 24 gachara: 17.2-181 mg / 24 h (nkezi, 54.8 mcg / awa 24), 5.74-60.3 nmol / 24 h (nkezi 18.3 nmol / 24 h) .

Insulin na C-peptide bụ ndị otu nnukwu ezinụlọ nke na-egbochi protein. C-peptide dị mkpa na ịtọbe insulin n'ụdị abụọ; yabụ, ọ bụ ihe ngosipụta nke imepụta insulin n’ime sel nke plọg.

Ọ bụ protein na - ejikọ aka na molekul proinsulin, site na nke ọ gbazere mgbe a gbanwere proinsulin ka ọ bụrụ insulin. Kpamkpam jikọrọ ọnụ nke sel dị iche iche, na-eme ka mmadụ mata usoro ọmụmụ ihe ma na-emetụta akara ngosipụta nke uto.

N'ịmepụta nguzogide insulin, a na-arụ ọrụ dị mkpa site na mkpụrụ ndụ ihe nketa na ihe gburugburu, karịchaa, oke ibu na oke ibu. Ahụ mmadụ na-achọ imeri enweghi mmetụta nke anụ ahụ site na ịba ụba mmepụta insulin site na mkpụrụ ndụ reat-pancreatic ((na-abawanye ụgwọ hyperinsulinemia - C-peptide).

Mkpa KNOWmata! Nsogbu nke thyroid gland? Onlychọrọ naanị kwa ụtụtụ ...

Ọbara ụgwọ hyperinsulinemia na mbụ merie nsonaazụ anụ ahụ na insulin ma na-ejikwa ọkwa suga dị mma. Mgbe mkpụrụ ndụ panc-pancreatic-emepụtaghị ụba insulin ogologo oge, ha na-aga n’ihu n’ihu.

Ọkwa insulin na plasma ọbara na-amalite ịda, nke na-eduga n'ọbara nke glucose n'ọbara (hyperglycemia) yana ngosipụta nke nnabata (ngosipụta) nke ụdị ọrịa shuga 2 nke ọrịa mellitus.

A na-enyocha C-peptide n'ọtụtụ ọnọdụ. Ihe ndị a na-anọchi anya isi, ọkachasị, site na ndị a:

ụdị ọrịa shuga ọria 1,
ọ bụrụ na-enyo enyo na mbelata nke mmepụta insulin site na mkpụrụ ndụ akwara ji ụdị shuga 2, onye emere mkpebi banyere ọgwụgwọ insulin,
n'ime ndị mmadụ na-enyo enyo ọrịa shuga mellitus ụdị LADA (ọrịa shuga autoimmune n'oge okenye),
iji chọpụta ihe kpatara hyperglycemia,
iji chọpụta nnukwu ọrịa ma ọ bụ nlọghachi hypoglycemia.

Valueskpụrụ belata nwere ike igosi ụdị ọrịa mellitus nke 1 ma ọ bụ 2, ọrịa shuga LADA, ma ọ bụ ịkwụsịlata mmepụta insulin site na iji insulin na-agbapụta. Enwere ike ịhụ ọkwa dị ala n'ihe ụnwụ nri, hypoglycemia na-abụghị physiology, ọrịa Addison, hypoinsulinism na mgbe ọrịa pancreatectomy gasịrị.

Ego C-peptide dị elu nwere ike ịme na ọkwa potassium dị ala n’ime afọ n’oge afọ ime ma n’etiti oke ibu.

Ọbara insulin dị na mkpụmkpụ mkpụmkpụ nke kromosome nke iri na otu. N'ime mkpụrụ ndụ sel nke pancreatic isuo nke Langerhans, mkpụrụ ndụ a na - abụ ihe omimi maka njikọta protin insulin.

Nzọụkwụ mbụ na insulin biosynthesis bụ nguzobe nke preproinsulin, nke, n'okpuru mmetụta nke otu prosthesis, na-agbanwe na proinsulin. Ọ mejupụtara pịpeiki peptide A (nsị nke amino acid 21) na B (nsị amino acid 30) nke insulin n'ọdịnihu.

Ejikọtara eriri abụọ a n'ọdụ mmiri akpọrọ C-peptide nwere nsị amino acid 35. A na-ekpocha Proinsulin site na protein n'ime C-peptide na insulin.

N'ime oge ikpochapu, C-peptide tụfuru amino acid 4 ma zoo n'ime mgbasa dịka otu siliki nwere 31 amino asịd.

Achọpụtara usoro nke C-peptide na 1967, ma rue mgbe puku afọ iri ọhụrụ, a na-ahụta naanị akara ngosi nke insulin insulin. Ka ọ dị ugbu a, a na-amata oke ọrụ ya mgbe ọ jikọrọ ọnụ nke sel dị iche iche, na-ebute nkwupụta mkpụrụ ndụ ma na-emetụta mmepụta nke ihe.

Na mgbakwunye, n'ọtụtụ anụ ahụ, ọ na-eme ka ATPase dabere na Na / K-enzyme nke mkpụrụ ndụ) na, site na usoro a na-akọwaghị, na-edozi mmezi ahụ na metabolism cell (metabolism) kpatara hyperglycemia.

Enwere ike ichikota nsogbu nke C-peptide na paragraf ndia:

nwere mmetụta pụtara ìhè na-apụtachaghị ìhè na-emetụta ogo na ọnụego mmepe nke vaskụla na mgbanwe mgbanwe akwara,
ọkwa dị elu na-egbochi nsị nke endothelial, belata nrapu nke albumin site na mgbidi vaskụla ma nwee mmetụta analgesic,
a gosipụtara na C-peptide, n'otu aka, bụ akara nke hyperinsulinemia na-emerụ ahụ, n'akụkụ nke ọzọ bụ ihe nchebe nke arịa ọbara na akwara site na mmetụta ọjọọ nke hyperinsulinemia na hyperglycemia.

Alzọ nyocha: nyocha RMS (ma ọ bụ ELISA) rụrụ, enwere nhọrọ atọ maka ikpebi:

Na afọ efu na mgbe mkpali nke glucagon: a na-achọpụta uru basal na nkeji 6 mgbe mkpali nke glucagon (1 mg intravenously). Uru uru aru nke C-peptide kariri 600 pmol / L, ma mgbe mkpali kwusiri ike, o kariri ugboro abụọ. Na mellitus na-arịa ọrịa shuga, C-peptide na-agbadata nke ukwuu n'okpuru obere ala ma ọ dịghị aza mkpali.
Ibu ọnụ na mgbe nri ụtụtụ ụfọdụ: a na-eme nnyocha ahụ n’afọ na-enweghị isi na minit 60 mgbe nri ụtụtụ zuru oke, nke a bụ: achịcha 100 g, 125 g nke obere obere abụba, 1 akwa, ị nwere ike teaụọ tii dị ọkụ.
N'ime usoro nke PTTG: a na-eme nlele on afọ efu, ma emesịa mgbe eburu ibu glucose ọnụ (75 g), na-abụkarị mgbe 60 na 120 gasịrị, n'ime nnwale ahụ, enwere ike ọbụna 30, 45, 90 na minit 180.

Ihe ndị a nwere ike imetụta nkọwa nke ndị na - egosi:

nnukwu hyperglycemia,
Ezinaụlọ gbasara akụrụngwa na nhichapu nke okike,
haemolysis (haemoglobin

Njirimara

Ọ na --eme na na afo efu, ọkwa C-peptide bụ ihe dịkarịsịrị mma ma ọ bụ gosipụta ala dị ala. Nke a na - eme ka ọ sie ike ịme nyocha ikpeazụ. Iji dokwuo anya nnwale kpaliri.

Maka iji ya, a na-eji glucagon injections, ma ọ bụ tupu nnwale, mmadụ kwesịrị ịnya ọkụ. Ọ ga na-echeta na glucagon bụ contraindicated maka ndị na-arịa ọbara mgbali elu.

Ọ bụrụ na a na-eme ọmụmụ ahụ na afọ na-enweghị isi, a na-ahapụ isiokwu ahụ ka ọ onlyụọ ntakịrị mmiri.

Iji ọgwụ ọ bụla anabataghị ya, ebe ọ bụ na ha nwere ike imetụta nsonaazụ ọmụmụ a.

Ọ bụrụ na ọ gaghị ekwe omume ịjụ iji ọgwụ a ma ọ bụ ọgwụ ahụ maka ebumnuche ebumnuche, mgbe ahụ ekwesịrị igosipụta nke a na mpempe akwụkwọ pụrụ iche.

Dịka iwu, oge kacha nta maka ịkwadebe nyocha ahụ bụ ihe dịka awa 3.Ngwa a kwadebere kwesịrị ekwesị maka nyocha ọnwa atọ, ma ọ bụrụhaala na ebe nchekwa ahụ dị -20 Celsius.

Nyocha na nkọwapụta nsonaazụ ya

Nkịtị bụ ọdịnaya nke C-peptide n’arụ na oke nke 0.78 ruo 1.89 ng / ml. Sistemu sis SI na aru oru ya 0.26-0.63 mmol / L.

Na ọkwa dị elu A na-ezokarị C-peptides:

Ọrịa shuga IIdị nke Abụọ
insulinoma
Ọrịa Hisenko-Cushing,
akụrụ ime
ọnụnọ nke ọrịa cirrhosis ma ọ bụ ịba ọcha n'anya n'ụdị dị iche iche.
polycystic ovary,
oke ibu (ụdị a kapịrị ọnụ).

Of estụ ọgwụ estrogens ugboro ugboro ma ọ bụ ọgwụ ọgwụ homonụ ọzọ nwekwara ike ime ka mmụba nke ọkwa C-peptide.

Obere dị ala mara na:

ọrịa shuga (ụdị nke m),
hypoglycemia nke wuru,
arụmọrụ na ebe ahụ.

Okwesiri iburu n’uche na okpukpu pere mpe, ihe ize ndu nke ibute nsogbu di iche-iche na-abawanye nke oma:

ezigbo nsogbu ọhụụ
ọnya anụ ahụ dị iche iche,
nsogbu siri ike na-arụ ọrụ na ngụgụ nri, dịka iwu, akụrụ, imeju,
mebie arịa na akwara nke ụkwụ, nke nwere ike ibute usoro gangrenous na mbepụ.

Maka nsonaazụ ebumnuche na-egosi ọnụnọ insulinoma, yana ọdịiche dị na hypoglycemia ụgha, ntụpọ C-peptide na mmekọrịta ha na ọkwa insulinoma. Ihe otu ma ọ bụ obere na-egosi na a na-emepụta insulin n'ime. Ọ bụrụ na ndị gosipụtara gafere ịdị n’otu, mgbe ahụ, nke a bụ ihe na-akpata ntinye na ikpughe insulin mpụga.

Ekwesịrị icheta na ụkpụrụ insulin na C-peptide nwere ike ịgbanwe ma ọ bụrụ na a chọpụta na mmadụ nwere ọrịa akụrụ na-arịa ọrịa ma ọ bụ ọrịa imeju.

Nkwupụta izugbe maka ịkwadebe maka nyocha ahụ

Njirimara nke nkwadebe maka nnyefe nke nyocha a, yana ike nke mmejuputa ya na ọnọdụ nke ọ bụla, bụ naanị dọkịta na-aga. Enwere ndụmọdụ n'ozuzu maka mmejuputa ya:

tupu iburu onye ọrịa kwesịrị ịhapụ iri nri ọ bụla maka awa 8,
ọ kachasị mma ị drinkụ mmiri naanị carbon, nke na-enweghị shuga ma ọ bụ adịghị ọcha ndị ọzọ.
amachibidoro ị alcoholụ mmanya ma ọ bụ ọgwụ nwere ya
Gbalịa ka ị toụ ọgwụ ọ bụla na-abụghị nke dị mkpa (mgbe ị na-ewere nke a, gwa ndị ọkachamara),
zere itinye aka na anụ ahụ ọ bụla, gbalịanụ izere ihe ndị nwere ike ịkpata,
Gbalịa izere ise sịga ọbụlagodi awa atọ tupu nyocha ahụ enyere.

Nsonaazụ nke nyocha ọgbara ọhụrụ

Sayensị ọgbara ọhụrụ esighi ike, na nsonaazụ nke ọmụmụ emere n'oge na-adịbeghị anya na-egosi na C-peptides abụghị naanị site na ngwaahịa insulin. Nke ahụ bụ, ihe a enweghị ihe omuma nke ọrịa ma na-arụ ọrụ, ọkachasị ndị mmadụ na-arịa ụdị ọrịa shuga dị iche iche.

Fọdụ ndị sayensị na-ekwu maka eziokwu ahụ bụ na otu nchịkwa insulin na peptide n'ụdị ọrịa shuga II na-ebelata ihe egwu nke nsogbu ndị nwere ike ịdapụta, gụnyere:

gbasara akwara
mmebi nke akwara na / ma ọ bụ arịa nke aka.

Obere obere peptide n'ime ọbara onye ọrịa nwere ike belata ihe egwu nke ịdabere na insulin ọ bụla.

Knowsnye maara, ma eleghị anya n'ọdịnihu a ga - enwe ọgwụ pụrụ iche nke peptide ga - enyere aka ịlụ ọgụ ma merie ọrịa shuga.

Ruo taa, etinyebeghị nsogbu na ọghọm dị na ụdị ọgwụgwọ a, mana agụmakwụkwọ mmụta dị iche iche na-aga n'ihu na-aga nke ọma.

Excellentzọ kachasị mma bụ nri nwere obere carb, nke oriri ya anaghị agafe ihe oriri achịcha 2.5. Usoro nri dị otú a mgbe niile na-enyere aka belata ị dependụ ọgwụ mgbe ọ bụla ị sugarụ ọgwụ shuga, yana insulin.

Na mgbakwunye, mmadụ ekwesịghị ichefu banyere usoro ịdị ọcha n'ozuzu, nke gụnyere ịgagharị mgbe niile na ikuku dị mma, ịjụ ihe ọjọọ niile, izere nchekasị, nleta mgbe niile na sanatoriums ọkachamara na ọgwụgwọ na mgbochi nke ọrịa endocrine.

C-peptides n’ime ọrịa shuga

Site na ụdị ọrịa mellitus ọ bụla, nyochaa ọnọdụ ya dị ezigbo mkpa maka onye ọrịa.

Nke a bụ nlezianya nyocha nke ọkwa glucose plasma. Enwere ike itinye usoro a site na enyemaka nke ngwaọrụ nchọpụta ọ bụla - glucometers.

Mana ọ dịghị ihe dị mkpa bụ nyocha nke C-peptide - ihe na-egosi mmepụta insulin n’ime ahụ na metabolism metabolism.

A na-eme nyocha dị otú ahụ naanị na ụlọ nyocha: ekwesịrị ịme usoro a mgbe niile maka ndị ọrịa nwere ọrịa shuga nke ụdị abụọ ahụ.

Gịnị bụ C-peptide

Sayensị sayensị na-enye nkọwa a:

C-peptide bụ ikwụsi ike nke ihe a na - arụ ọrụ n’ime ahụ mmadụ - proinsulin.

A na - ekewapụta C-peptide na insulin n'oge nke ikpeazụ: yabụ, ọkwa nke C-peptide na - egosi ọkwa insulin.

Kedu ka esi ejikọ C-peptide n'ime ahụ? Proinsulin, nke emepụtara na pancreas (nke ka nke ọma, n'ime mkpụrụ ndụ sel nke pancreatic) bụ nnukwu polypeptide silite nwere nsị amino acid 84. N’ụdị a, a napụrụ ihe ndị ahụ mmebi homonụ.

Mgbanwe nke proinsulin na-adịghị arụ ọrụ na insulin na-apụta n'ihi ngagharị nke proinsulin site na ọgịrịga nke dị n'ime sel ahụ ruo n'usoro mkpụrụ ndụ dị na usoro nke mmebi akụkụ nke molekul. N'otu oge ahụ, nsị amino acid 33, nke a maara dị ka peptide na-ejikọta ma ọ bụ C-peptide, na-apụ n'anya site n'otu njedebe nke yinye.

Ya mere, n’ime ọbara ahụ, enwere njikọ ọnụ n’etiti C-peptide na insulin na-arụ.

Laghachi n’ihe dị n’ime

Kedu ihe kpatara m ji chọọ nyocha C-peptide?

Iji nweta nghọta zuru oke banyere isiokwu ahụ, ịkwesịrị ịghọta ihe mere na a na-eme nnwale ụlọ nyocha na C-peptide, ọ bụghị na insulin n'ezie.

Nkwadebe insulin ọgwụ nwere ọgwụ C-peptide, yabụ, mkpebi siri ike nke ihe a na sel ọbara na-enye anyị ohere ịtụle ọrụ nke mkpụrụ ndụ akwara pancreatic na ndị ọrịa na-anata ọgwụgwọ.

Ọkwa basal nke C-peptide, na karịchaa nsonaazụ nke ihe a mgbe ịbịnyechara shuga, na-eme ka o kwe omume ịchọpụta ọnụnọ nke nnabata (ma ọ bụ nguzogide) onye ọrịa ahụ na insulin.

Ya mere, a na-ehiwe usoro nke mgbaghara ma ọ bụ iwe ọkụ na-edozi mmezi ọgwụgwọ.

Site na ịba ụba nke ọrịa shuga mellitus (ọkachasị ụdị nke m), ọdịnaya nke C-peptide n'ime ọbara dị ala: nke a bụ ihe akaebe zuru oke nke erughi insulin nke endogenous (esịtidem). Ọmụmụ nyocha nke mkpokọta peptide na-eme ka nyocha nke insulin insulin na ọnọdụ ụlọ ọgwụ dị iche iche.

Oke nke insulin na C-peptide nwere ike ịdị iche ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa imeju na akụrụ.

Insulin bụ metabolized n'ụzọ bụ isi na parenchyma imeju, A na - ekepụta C-peptide site na akụrụ. Ya mere, ndị na-egosi oke nke C-peptide na insulin nwere ike ịdị mkpa maka nkọwa ziri ezi nke data na ọrịa nke imeju na akụrụ.

Laghachi n’ihe dị n’ime

Kedu ka nyocha nke C-peptide dị

A na-enyocha ọbara maka C-peptide na afọ efu, belụsọ na enwere nduzi pụrụ iche site na endocrinologist (ekwesịrị ịgakwuru ọkachamara a ma ọ bụrụ na ị na-enyo ọrịa metabolic). Oge ibu ọnụ tupu inye ọbara bụ elekere 6-8: oge kachasị mma maka inye ọbara bụ ụtụtụ mgbe ị tetara.

Nnyocha ọbara onwe ya adịghị iche na nke mbụ: akwara akwara akwara, ọbara na-anakọta na tube tọgbọ (mgbe ụfọdụ a na-eji eriri gel). Ọ bụrụ na hematomas etolite mgbe a na - esochi ya, dọkịta kọwaa mmakọ ọkụ. Ọbara e weghaara gafere n'ọwa mmiri, nke na-ekewa ọbara ya na friji, wee nyocha ya n'ụlọ nyocha ahụ site na iji ihe eji eme ihe.

Nhọrọ kacha mma maka nchọpụta ọrịa bụ ịme nnwale abụọ:

nyocha nke ibu ọnụ
kpaliri.

Mgbe ị na-enyocha afọ efu, a na-ahapụ gị ị drinkụ mmiri, mana ị kwesịrị ịhapụ ị refụ ọgwụ ọ bụla nwere ike imetụta izi ezi nke nsonaazụ nyocha ahụ. Ọ bụrụ na ọgwụ enweghị ike ịkagbu maka ọgwụ na ahụike, a ga-egosipụta eziokwu a n'ụdị akwụkwọ ndekọ.

Oge nyocha ihe dịkarịa ala bụ awa 3. Enwere ike iji Archive whey echekwara na -20 Celsius C ruo ọnwa 3.

Laghachi n’ihe dị n’ime

Kedu ihe bụ ihe ngosipụta nke nyocha maka C-peptides

Mgbanwe dị na ọkwa nke C-peptide na serum kwekọrọ na ume insulin na ọbara. Ọdịnaya nke peptide na-ebu ọnụ sitere na 0.78 ruo 1.89 ng / ml (na sistemụ SI, 0.26-0.63 mmol / l).

Maka nchoputa nke insulinoma na ihe di iche na hypoglycemia ugha (eziokwu), a na-ekpebi nha nke C-peptide n’ogo insulin.

Ọ bụrụ na rashọn na otu ma ọ bụ ihe na-erughị uru a, nke a na-egosi ịba ụba nke insulin nke ime. Ọ bụrụ na ndị na - egosi ihe karịrị 1, nke a bụ ihe akaebe nke iwebata insulin nke mpụga.

Laghachi n’ihe dị n’ime

Ọrụ C peptide

Ndị na-agụ akwụkwọ nwere ike inwe ajụjụ dabara adaba: gịnị kpatara anyị ji achọ C-peptides n’ahụ?

Ruo n’oge na-adịbeghị anya, e kwenyere na akụkụ a nke usoro amino acid bụ adịghị arụ ọrụ nke biolojiiki na ọ bụ ngwaahịa sitere na nguzobe insulin.

Ma ihe omumu ohuru nke ndi endocrinologists na diabetologists mere ka nkwubi okwu bu na ihe a abaghị uru ọ bụla ma na-ekere òkè na ahụ, karịsịa maka ndị ọrịa nwere ọrịa shuga.

O kwere omume na n'oge na-adịghị anya, a ga-akwado ndị ọrịa mamịrị C-peptide yana insulin, mana ka ọ dị ugbua enwetabeghị ihe ọghọm na ọghọm ọgwụ ndị dị etu ahụ. Nnyocha nyocha sara mbara n'isiokwu a ka ga-abịa.

Laghachi n’ihe dị n’ime

C-peptide: mkpebi siri ike, ịkọwa ihe nyocha (usoro)

C-peptide pụtara “ejikọ peptide”, sụgharịa ya na Bekee. Nke a bụ ihe na - egosi izochi insulin nke onwe gị. Ọ na-egosi ọkwa nke mkpụrụ ndụ beta pancreatic.

Na mmụba nke glucose, ụmụ irighiri proinsulin na-agbadaru n'ime peptide na insulin. Nchikota di otua n’etiti obara na emekorita ibe ya. N'ihi ya, iwu bụ 5: 1.

Ọ bụ nyocha nke C-peptide na-enye anyị ohere ịghọta na nzuzo (mmepụta) nke insulin belatara, yana ikpebi ohere nke ọdịdị insulinoma, ya bụ, ọria.

A na-ahụta ọkwa dị elu nke ihe.

insulin na-arịa ọrịa shuga mellitus,
gbasara akwara
iji ọgwụ homonụ,
insulinoma
ọbara mgbali beta.

A gbadara ọkwa c-peptide bụ njiri mara maka:

shuga insulin na-akpata insulin na ọnọdụ hypoglycemic,
ọnọdụ nrụgide.

Normkpụrụ nke C-peptide na nkọwa

Normkpụrụ nke C-peptide bụ otu na ụmụ nwanyị na ụmụ nwoke. Normkpụrụ ahụ anaghị adabere na afọ ndị ọrịa ma ọ bụ 0.9 - 7.1ng / ml. Dọkịta maka ụmụaka n'ụdị nke ọ bụla ka dọkịta kpebiri.

Dịka iwu, ịdị omimi nke C-peptide n'ime ọbara kwekọrọ na ume nke ntinye insulin. Normkpụrụ nke C-peptide na-ebu ọnụ bụ 0.78 -1.89 ng / ml (SI: 0.26-0.63 mmol / L).

Maka ụmụaka, iwu maka nyocha ọbara na-agbanwe agbanwe. Agbanyeghị, ihe a na nwatakịrị n’oge nyocha banyere afọ na-enweghị isi nwere ike ịdị obere karịa ka mbelata nke usoro ahụ, ebe C-peptide na-ahapụ mkpụrụ ndụ beta n’ime ọbara naanị mgbe nri gachara.

Iji mata ọdịiche dị n'etiti insulin na hypoglycemia n'ezie, ọ dị mkpa iji chọpụta nha nke insulin na ọdịnaya C-peptide.

Ọ bụrụ na rashtin ahụ bụ 1 ma ọ bụ ihe na-erughị, nke a na-egosi mmụba nke insulin na-ejedebe. Ọ bụrụ na akara 1 gafere, enwere ike ịrụ ụka na a na-elekọta insulin na mpụga.

Enwere ike ịbawanye C-peptide na:

ọbara mgbali nke sel nke agwaetiti nke Langerhans. A na-akpọ mpaghara nke Langerhans mpaghara nke a na-eme ka insulin na-arụ ọrụ,
oke ibu
insulinoma
ụdị ọrịa shuga 2
Ọrịa cancer akpa ume
ogologo oge ọrịa QT,
ojiji nke sulfonylureas.

C-peptide na-ebelata mgbe:

mmanya hypoglycemia,
ụdị shuga 1.

Ihe dị na ọbara nwere ike ibelata maka ihe abụọ:

Ọrịa shuga mellitus
Ojiji nke thiazolidinediones, dịka ọmụmaatụ troglitazone ma ọ bụ rosiglitazone.

N'ihi ọgwụgwọ insulin, enwere ike ịbelata ogo nke C-peptide. Nke a na-egosi mmeghachi omume dị mma nke pancreas na - apụta na insulin "arụsị" dị n'ahụ.

Otodi, odi otutu mgbe, odi n’iru na onodu ahu di n’ime obara nke peptide n’onu efu bu nke oma ma obu ihe kari. Nke a pụtara na iwu enweghị ike ikwu ụdị ọrịa shuga mmadụ nwere.

Dabere na nke a, a na-atụ aro ịme ule mkpali pụrụ iche ka amata usoro nke onye enyere. Enwere ike ime omumu ihe a site na iji:

Glucagon injections (onye insulin antagonist), ọ na-ike contraindicated maka ndị nwere ọbara mgbali elu ma ọ bụ pheochromocytoma,
Ule nnabata glucose.

Ọ kachasị mma ịgafe ihe ngosi abụọ: nyocha banyere afọ efu, yana ule kpaliri. Ugbu a ụlọ nyocha dị iche iche na-eji usoro dị iche iche kọwaa ihe dị iche iche, na usoro dịtụ iche.

N'inwetara nsonaazụ nyocha ahụ, onye ọrịa ahụ nwere ike iji ya nyochaa onwe ya na ụkpụrụ ntụnye aka.

Peptide na ọrịa shuga

Ọgwụ ọgbara ọhụrụ kwenyere na ịchịkwa ọkwa nke C-peptide nke ọma na-egosipụta oke insulin karịa ịtụpụta insulin n’onwe ya.

Enwere ike ịkpọ uru nke abụọ eziokwu ahụ na site na enyemaka nke nyocha ọ dị mfe ịmata ọdịiche dị n'etiti insulin endogenous (nke ime) na insulin exogenous. N'adịghị ka insulin, C-peptide anaghị anabata ọgwụ mgbochi insulin, ọgwụ nje ndị a egbughịkwa ya.

Ebe ọ bụ na ọgwụ insulin adịghị enwe ọgwụ a, itinye uche ya n'ọbara onye ọrịa na-eme ka o kwe omume ịtụle arụmọrụ nke mkpụrụ ndụ beta. Icheta: sel beta nke na - eme ka aru mmadu mejuputa insulin.

N’ime onye nwere ọrịa shuga, ọkwa nke C-peptide, na mgbakwunye ya mgbe ịbịnyechara shuga, na-eme ka ọ kwe omume ịghọta ma enwere nnabata na mmetụta nke insulin.

Na mgbakwunye, a na-ekpebi usoro mgbaghara, nke ga-enye gị ohere idozi usoro ọgwụgwọ dị mma. Ọ bụrụ na ọrịa shuga na-aka njọ, mgbe ahụ ọkwa nke ihe ahụ anaghị aba ụba, kama wedata ala. Nke a pụtara na insulin ọgwụ endogen ezughi.

N'iburu n'uche ihe ndị a niile, anyị nwere ike ikwu na nyocha ahụ na-enye anyị ohere inyocha nzuzo nke insulin n'ọnọdụ dị iche iche.

Eterchọpụta ọkwa nke C-peptide na-enyekwa ohere maka ịkọwa mgbanwe dị na ịba ụba insulin n'oge eji ya na imeju.

N'ime ndị nwere ọrịa shuga nke nwere ọgwụ mgbochi ọgwụ insulin, enwere ike ịhụ ọkwa C-peptide ụgha na-adịghị mma n'ihi ọgwụ mgbochi na-agagharị na proinsulin. Ndị ọrịa nwere insulinoma nwere ọkwa ịrị elu nke C-peptide.

Ọ dị mkpa ịmara na ekwesịrị ịkwụ ụgwọ nlebara anya pụrụ iche iji gbanwee ịta nke otu ihe na ndị mmadụ na-arụ ọrụ na insulinomas. Nnukwu C-peptide dị elu na-egosi ma ọnya afọ ma ọ bụ metastases.

Achoro nyocha maka:

Iche iche usoro ịchọpụta ụdị ọrịa shuga,
Nhọrọ nke ụdị ọgwụgwọ ọgwụ,
Chohọrọ ụdị ọgwụ na usoro onunu ogwu,
Mkpebi nke ụkọ sel nke beta
Nchoputa nke hypoglycemic steeti,
Ntụle nke mmepụta insulin,
Mkpebi nguzogide insulin,
Otu ihe akara nke steeti ma kpochapu pancreas.

Ọgwụ ọgbara ọhụrụ

Ruo ogologo oge, ọgwụ ọgbara ọhụrụ ekwuola na ihe ahụ n’onwe ya anaghị ebu ọrụ ọ bụla ma na ọ bụ naanị n ’usoro ya dị mkpa. N’ezie, adọwara ya na proinsulin mọbụ mepee ụzọ n’ụzọ insulin na-aga n’ihu, mana nke ahụ bụ ihe niile.

Kedu ihe pụtara C-peptide? Mgbe ọtụtụ afọ nke nyocha na ọtụtụ narị akwụkwọ sayensị, ọ bịara mara na ọ bụrụ na a na-enye ndị ọrịa kansa ọrịa shuga yana C-peptide, mgbe ahụ enwere mbelata dị ukwuu n'ihe ize ndụ nke ọrịa shuga dị ka:

nephropathy
neuropathy
ọrịa shuga na-arịa ọrịa mamịrị.

Banyere nke a ugbu a, ndị sayensị kwuru na ntụkwasị obi zuru oke. Na agbanyeghị, ọ nwebeghị ike ịdabere na usoro iji chekwaa ihe eji edozi ihe a.

Biko rịba ama: n’oge na-adịbeghị anya, nkwupụta sitere na ọnụ ọgụgụ ndị ọrịa na-agwọ ọrịa shuga na ha na-agwọ ọrịa shuga mellitus n’ihi iwebata naanị otu ụzọ ọrụ ebube abụrụla ugboro ugboro. Treatmentdị “ọgwụgwọ” a na-abụkarị oke ọnụ.

N'ọnọdụ ọ bụla ị ga-ekwenye na ụdị ọgwụgwọ ahụ a na-enyo enyo. Ọnụego ihe ahụ, ịkọwapụta na usoro ọgwụgwọ ọzọ kwesịrị ịdị n'okpuru nlekọta nke dibịa ruru eru.

N’ezie, enwere nnukwu ọdịiche dị n’etiti nyocha ụlọ ọgwụ na omume. Ya mere, n'ihe gbasara C-peptide, a ka nwere arụmụka na gburugburu ọgwụ. Enweghị ozi ezughi oke na nsonaazụ yana ọghọm nke C-peptide.

Normkpụrụ nke C-peptide n'ime ahụ

Agnochọpụta ọrịa shuga mellitus chọrọ ọtụtụ ọmụmụ. Edere onye ọrịa ahụ nnwale ọbara na mmamịrị maka shuga, ule nnwale na glucose.

Na ọrịa shuga mellitus, mkpebi nke C-peptide n'ime ọbara bụ ihe amanyere.

Nsonaazụ nyocha a ga - egosi ma hyperglycemia bụ nsonaazụ insulin zuru oke ma ọ bụ na ọ dị ala. Kedu ihe na-atụ egwu mbelata ma ọ bụ ịrị elu na C-peptide, anyị ga-enyocha n'okpuru.

Enwere nyocha nke nwere ike inyocha ọrụ nke agwaetiti nke Langerhans na pancreas ma gosipụta ọnụọgụ nke homonụ hypoglycemic dị n'ahụ. A na-akpọ ihe ngosipụta a peptide ma ọ bụ C-peptide (C-peptide).

Anụ a na-echere bụ ụdị ebe a na-edobe homonụ protein. A na-echekwa ya ebe ahụ n'ụdị proinsulin. Mgbe mmadụ gbaruru shuga, proinsulin na-emebi ma nwee ọgwụ insulin.

N'ime ahụike, rashọn ha kwesịrị ịbụ 5: 1 oge niile. Mkpebi nke C-peptide na-ekpughe mbelata ma ọ bụ mmụba na mmepụta insulin. N'okwu nke mbụ, dọkịta nwere ike ịchọpụta ọrịa shuga, na nke abụọ, insulin.

N'okpuru ọnọdụ na ọrịa dị a isaa ka a na-eme nyocha?

Ọrịa nke edepụtara nyocha:

ụdị 1 na ụdị ọrịa shuga 2
ọrịa imeju dị iche iche
polycystic ovary,
etuto ahụ na-egbu mgbu,
ịwa ahụ
Ọrịa Cushing
Nyochaa ọgwụgwọ hormone maka ụdị ọrịa shuga 2.

Insulin dị mkpa nye mmadụ. Nke a bụ ihe bụ isi hormone na-emetụta metabolism metabolism na mmepụta ume. Nnyocha nke na-ekpebi ọkwa insulin dị n'ọbara abụghị ihe ziri ezi mgbe niile.

Ihe kpatara ya bu:

Na mbu, ana - emeju insulin n’ime akwara. Mgbe mmadụ rịrị shuga, homonụ ahụ na-abanye n’imeju. N'ebe ahụ, ụfọdụ n'ime ya edozi, ebe akụkụ nke ọzọ na-arụ ọrụ ya ma belata shuga. Ya mere, mgbe ị na-ekpebi ọkwa nke insulin, ọkwa a ga-adị ala mgbe niile karịa njikọta nke pancreas.
Ebe ọ bụ na mwepụta nke insulin na-apụta mgbe erichara carbohydrates, ọkwa ya na-ebili mgbe erichara nri.
A na - enweta data na - ezighi ezi ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa mellitus na - arịa ọrịa insulin.

N'aka nke ya, C-peptide anaghị edozi ebe ọ bụla wee banye n'ọbara ọbara ozugbo, yabụ ọmụmụ a ga-egosi ọnụọgụgụ na ọnụego homonụ nke pancreas zoro ezo. Na mgbakwunye, compound esighi na ngwaahịa nwere glucose, ya bụ, ọkwa ya anaghị abawanye mgbe ị risịrị nri.

Kedu otu esi eme nyocha ahụ?

Nri abalị 8 tupu ị bloodụ ọbara kwesịrị ịdị ọkụ, enweghị nri nwere abụba.

Algorithm nyocha:

Onye ọrịa na-abịa na afọ na-enweghị oghere gaa na ụlọ ịnakọta ọbara.
Nọọsụ na-anara ya ọgwụ ọjọọ.
A na-etinye ọbara n'ime ọkpọkọ pụrụ iche. Mgbe ụfọdụ o nwere gel pụrụ iche ka ọbara ya wee ghara kechie.
Mgbe ahụ, a na-etinye tube ahụ na centrifuge. Ihe a dị mkpa iji wee kewapụ plasma ahụ.
Mgbe ahụ, a na-etinye ọbara ahụ na friza ma jụọ oyi-ogo.
Mgbe nke ahụ gasịrị, a na-ekpebi nha peptide na insulin n'ime ọbara.

Ọ bụrụ na echere onye ọrịa ahụ ọrịa shuga, a na-edenye ya ule nyocha. Ọ mejupụtara na ntinye nke glucagon intravenal ma ọ bụ itinye glucose. Mgbe ahụ enwere mmachi nke shuga ọbara.

Olee ihe si na ya pụta?

Ọmụmụ ihe ahụ na-egosi nsogbu ahụ, yabụ isi iwu bụ idobe nri.

Ndụmọdụ ndị bụ isi maka ndị ọrịa na-enye ọbara na C-peptide:

8 awa ngwa ngwa tupu onyinye ọbara,
ị nwere ike ị drinkụ mmiri na-abụghị carbonated,
ị gaghị a alcoholụ mmanya ụbọchị ole na ole tupu ọmụmụ ihe ahụ,
belata nrụgide anụ ahụ na nke mmetụta uche,
a doụ sịga awa atọ tupu ọmụmụ ihe ahụ.

Normkpụrụ maka ụmụ nwoke na ụmụ nwanyị bụ otu ihe sitere na 0.9 ruo 7, 1 μg / L. Nsonaazụ nọọrọ onwe ya na ọgbọ na okike. Ekwesiri icheta na n'ụlọ nyocha dị iche iche nsonaazụ nke ụkpụrụ nwere ike ịdị iche, yabụ, ekwesịrị iburu ụkpụrụ ntụnye n'uche. Kpụrụ ndị a bụ nkezi maka laabu a ma guzobe mgbe nyochachara nke ndị ahụike.

Ozizi vidio banyere ihe kpatara ọrịa shuga:

N'ọnọdụ dị a isaa ka ọkwa dị n'okpuru nkịtị?

Ọ bụrụ na ọkwa peptide dị ala, yana shuga, na ntụle, dị elu, nke a bụ ihe ịrịba ama nke ọrịa shuga. Ọ bụrụ na onye ọrịa ahụ dị obere ma nwee oke mmụọ, o yikarịrị ka ọ ga-arịa ọrịa shuga 1.

A ga-enye ndị ọrịa agadi na ebumnuche oke ibu oke ụdị shuga 2 na usoro gbagọrọ agbagọ. N'okwu a, a ga-egosi onye ọrịa inle inulin.

Na mgbakwunye, onye ọrịa ahụ chọrọ nyocha ọzọ.

nyocha fundus
na-ekpebi steeti arịa na irighiri akwara nke ala nsọtụ.
mkpebi nke imeju na ọrụ akụrụ.

Akụkụ ahụ bụ "ebumnuche" ma na-ata ahụhụ na isi nwere nnukwu glucose n'ime ọbara. Ọ bụrụ na nyochachaa onye ọrịa ahụ nsogbu na akụkụ ndị a, mgbe ahụ ọ ga-achọ iweghachite ọkwa glucose nkịtị na ọgwụgwọ ọzọ nke akụkụ ahụ metụtara.

Mbelata peptide na - emekwa:

mgbe ọwachara akụkụ ahụ nke pancreas,
hypoglycemia artificial, ya bụ, mbelata shuga ọbara nke inje insulin butere.

N'ọnọdụ dị a isaa dị larịị karịa ụkpụrụ?

Nsonaazụ nke otu nyocha agaghị ezu, yabụ ekenye onye ọrịa ọ dịkarịa ala nyocha ọzọ iji chọpụta ọkwa shuga dị n'ọbara.

Ọ bụrụ na C-peptide dị elu ma shuga adịghị, mgbe ahụ, a na-achọpụta onye ọrịa na insulin resistance ma ọ bụ proiabetes.

N'okwu a, onye ọrịa ahụ achọghị ọgwụ insulin tupu ya, mana ọ kwesịrị ngwa ịgbanwe ụzọ ndụ ya. Jụ omume ọjọọ, bido igwu egwuregwu ma rie nri.

Ọnụọgụ C-peptide na glucose dị elu na-egosi ọnụnọ nke ọrịa shuga 2. Dabere n'ịdị njọ ọrịa ahụ, enwere ike ịnye mmadụ mbadamba ọgwụ ma ọ bụ ọgwụ insulin. A na-enye homonụ ahụ naanị ihe ogologo oge, 1 - ugboro 2 n'ụbọchị. Ọ bụrụ na achọtara ihe niile achọrọ, onye ọrịa nwere ike zere injers ma nọrọ naanị mbadamba.

Na mgbakwunye, mmụba na C-peptide ga-ekwe omume na:

insulinoma - akwara nke na - eme ka insulinoma hie nne,
insulin iguzogide - a ọnọdụ nke anụ ahụ mmadụ na-atụkwasị uche nke insulin,
polycystic ovary - ọrịa nke nwanyi na - ebute ọrịa ụkwara ara.
odida akwara nke na - egbu egbu - enwere ike ibute ọrịa shuga zoro ezo.

Mkpebi nke C-peptide n'ime ọbara bụ nyocha dị mkpa na nyocha nke ọrịa shuga mellitus na ụfọdụ ọrịa ndị ọzọ. Nchoputa oge na ọgwụgwọ oria bidoro ga - enyere aka ichekwa ahụike na ndu ogologo.

Akwukwo ndi ozo ndi ozo choro

Ọdịnaya nkịtị

Ofkpụrụ nke peptides sitere na 0.26 ruo 0.63 mol / L, ọ bụ ezie na a na-eji ndị na-eme nha ndị ọzọ na nyocha ahụ. A na-agbakọ ịba ụba nke ihe dị na nanogram kwa millilita ọbara, n'ọnọdụ nke a ụkpụrụ bụ 0.9-7.1 ng / ml. Gapdị ọdịiche ahụ dị ukwuu n'ọtụtụ nhọta nkịtị bụ n'ihi na ndị mmadụ nwere njirimara dị iche iche:

aru
afọ
ọrịa na-adịghị ala ala
ọrịa dị iche iche (ARVI, Influenza),
eto eto homonụ.

Obere dị ala

Dị ala ma e jiri ya tụnyere ọkwa nkịtị nke C-peptide mgbe:

Ọrịa shuga 1dị 1
Ọkpụkpụ hypoglycemia,
Surgerywa ahụ a na-ewepu pesọre.

Ọrụ C peptide

Ndị na-agụ akwụkwọ nwere ike inwe ajụjụ dabara adaba: gịnị kpatara anyị ji achọ C-peptides n’ahụ?

Ruo n’oge na-adịbeghị anya, e kwenyere na akụkụ a nke usoro amino acid bụ adịghị arụ ọrụ nke biolojiiki na ọ bụ ngwaahịa sitere na nguzobe insulin.

Ma ihe omumu ohuru nke ndi endocrinologists na diabetologists mere ka nkwubi okwu bu na ihe a abaghị uru ọ bụla ma na-ekere òkè na ahụ, karịsịa maka ndị ọrịa nwere ọrịa shuga.

Laghachi n’ihe dị n’ime

C-peptide: mkpebi siri ike, ịkọwa ihe nyocha (usoro)

C-peptide pụtara “ejikọ peptide”, sụgharịa ya na Bekee. Nke a bụ ihe na - egosi izochi insulin nke onwe gị. Ọ na-egosi ọkwa nke mkpụrụ ndụ beta pancreatic.

Na mmụba nke glucose, ụmụ irighiri proinsulin na-agbadaru n'ime peptide na insulin. Nchikota di otua n’etiti obara na emekorita ibe ya. N'ihi ya, iwu bụ 5: 1.

Ọ bụ nyocha nke C-peptide na-enye anyị ohere ịghọta na nzuzo (mmepụta) nke insulin belatara, yana ikpebi ohere nke ọdịdị insulinoma, ya bụ, ọria.

A na-ahụta ọkwa dị elu nke ihe.

insulin na-arịa ọrịa shuga mellitus,
gbasara akwara
iji ọgwụ homonụ,
insulinoma
ọbara mgbali beta.

A gbadara ọkwa c-peptide bụ njiri mara maka:

shuga insulin na-akpata insulin na ọnọdụ hypoglycemic,
ọnọdụ nrụgide.

Atụmatụ nyocha

Nyocha C-peptide bụ mkpebi nke ọnụọgụ protein nke proinsulin n'ọbara ọbara site na iji usoro immunochemiluminescent.

Nke mbu, a na - agbanye insulin n’ime ihe, proinsulin, n’ime sel beta nke pancreas, a na - aru oru ya naanị mgbe obara di n’ọbara gbagoro site na ikpochapu ihe ndi ozo - protein C-peptide n’ime ya.

Molecules nke insulin na C-peptide na-abanye n'ọbara ọbara ma na-ekesa ebe ahụ.

Iji n’ezie kpebie ego nke insulin nwere ọgwụ ndị na-egbochi ọrụ, nke na-agbanwe ihe ngosi, na-eme ka ha pere mpe. A na-ejikwa ya maka mmebi imeju siri ike.
Iji chọpụta ụdị ọrịa shuga mellitus na atụmatụ nke mkpụrụ ndụ beta pancreatic maka ịhọrọ usoro ọgwụgwọ.
Ịchọpụtapụta akpụ akpụ nke pancreas mgbe mwepụchara ya nke ọma.

Edere ule ọbara maka ọrịa ndị a:

Ọrịa shuga ,dị nke mbụ, nke a na-agbadata ọkwa protein.
Elldị shuga abụọ nke ọrịa mellitus, nke ngosipụta dị elu karịa nke nkịtị.
Mellitus na-arịa ọrịa shuga na-eguzogide ọgwụ, n'ihi mmepụta nke ọgwụ mgbochi nye ndị na - anabata insulin, ebe a na - agbada C-peptide.
Ọnwụ nke mwepụ ọrịa kansa na-akpata oge.
Infertility na ihe kpatara ya - polycystic ovary.
A na-akọwapụta ọrịa shuga na-arịa ọrịa mellitus (enwere ike ibute nwata ahụ).
Ọrịa dị iche iche na nrụrụ nke pancreas.
Somatotropinoma, ebe a na-atụkwa elu C-peptide.
Ọrịa Cushing.

Na mgbakwunye, mkpebi nke ihe dị n’ime ọbara mmadụ ga-ekpughe ihe kpatara hypoglycemic steeti na ọrịa shuga. Ihe ngosi a na-abawanye site na insulinoma, ojiji nke ọgwụ na-eme ka okpukpo okpukpo.

Edere ọmụmụ ihe ma ọ bụrụ na mmadụ emee mkpesa:

n'ihi na akpịrị ịkpọ nkụ mgbe niile
mmụba mmamịrị,
I nweta ibu.

Y’oburu n’inyocha oria obia, ya mere ihe ahu di iche iche itule ogo ogwu. Ọgwụ na-ezighi ezi na-eduga n'ụdị na-adịghị ala ala, ọtụtụ mgbe, na nke a, ndị mmadụ na-eme mkpesa banyere ọhụhụ na -ewelata ụkwụ na ụkwụ.

Na mgbakwunye, enwere ike ịchọpụta ihe ịrịba ama nke arụ akụrụ na oke ọbara mgbali.

Maka nyocha, a na-ewere ọbara venous n'ime igbe plastic. N'ime awa asatọ tupu nyocha ahụ, onye ọrịa enweghị ike iri nri, mana ị nwere ike ị drinkụ mmiri.

Ọ bụ ihe amamihe dị na ị andụ sịga ma ọ bụ ịghara inwe nrụgide anụ ahụ na nke mmetụta uche awa atọ tupu usoro ahụ. Mgbe ụfọdụ, a na-achọkarị mmezi insulin site na endocrinologist. Enwere ike ịmara nsonaazụ nyocha ahụ ka awa 3 gachara.

Normkpụrụ nke C-peptide na nkọwa

Dịka iwu, ịdị omimi nke C-peptide n'ime ọbara kwekọrọ na ume nke ntinye insulin. Normkpụrụ nke C-peptide na-ebu ọnụ bụ 0.78 -1.89 ng / ml (SI: 0.26-0.63 mmol / L).

Iji mata ọdịiche dị n'etiti insulin na hypoglycemia n'ezie, ọ dị mkpa iji chọpụta nha nke insulin na ọdịnaya C-peptide.

Enwere ike ịbawanye C-peptide na:

ọbara mgbali nke sel nke agwaetiti nke Langerhans. A na-akpọ mpaghara nke Langerhans mpaghara nke a na-eme ka insulin na-arụ ọrụ,
oke ibu
insulinoma
ụdị ọrịa shuga 2
Ọrịa cancer akpa ume
ogologo oge ọrịa QT,
ojiji nke sulfonylureas.

C-peptide na-ebelata mgbe:

mmanya hypoglycemia,
ụdị shuga 1.

Ihe dị na ọbara nwere ike ibelata maka ihe abụọ:

Ọrịa shuga mellitus
Ojiji nke thiazolidinediones, dịka ọmụmaatụ troglitazone ma ọ bụ rosiglitazone.

N'ihi ọgwụgwọ insulin, enwere ike ịbelata ogo nke C-peptide. Nke a na-egosi mmeghachi omume dị mma nke pancreas na - apụta na insulin "arụsị" dị n'ahụ.

Otodi, odi otutu mgbe, odi n’iru na onodu ahu di n’ime obara nke peptide n’onu efu bu nke oma ma obu ihe kari. Nke a pụtara na iwu enweghị ike ikwu ụdị ọrịa shuga mmadụ nwere.

Dabere na nke a, a na-atụ aro ịme ule mkpali pụrụ iche ka amata usoro nke onye enyere. Enwere ike ime omumu ihe a site na iji:

Glucagon injections (onye insulin antagonist), ọ na-ike contraindicated maka ndị nwere ọbara mgbali elu ma ọ bụ pheochromocytoma,
Ule nnabata glucose.

N'inwetara nsonaazụ nyocha ahụ, onye ọrịa ahụ nwere ike iji ya nyochaa onwe ya na ụkpụrụ ntụnye aka.

Peptide na ọrịa shuga

Ọgwụ ọgbara ọhụrụ kwenyere na ịchịkwa ọkwa nke C-peptide nke ọma na-egosipụta oke insulin karịa ịtụpụta insulin n’onwe ya.

N’ime onye nwere ọrịa shuga, ọkwa nke C-peptide, na mgbakwunye ya mgbe ịbịnyechara shuga, na-eme ka ọ kwe omume ịghọta ma enwere nnabata na mmetụta nke insulin.

N'iburu n'uche ihe ndị a niile, anyị nwere ike ikwu na nyocha ahụ na-enye anyị ohere inyocha nzuzo nke insulin n'ọnọdụ dị iche iche.

Eterchọpụta ọkwa nke C-peptide na-enyekwa ohere maka ịkọwa mgbanwe dị na ịba ụba insulin n'oge eji ya na imeju.

Achoro nyocha maka:

Iche iche usoro ịchọpụta ụdị ọrịa shuga,
Nhọrọ nke ụdị ọgwụgwọ ọgwụ,
Chohọrọ ụdị ọgwụ na usoro onunu ogwu,
Mkpebi nke ụkọ sel nke beta
Nchoputa nke hypoglycemic steeti,
Ntụle nke mmepụta insulin,
Mkpebi nguzogide insulin,
Otu ihe akara nke steeti ma kpochapu pancreas.

Ọgwụ ọgbara ọhụrụ

nephropathy
neuropathy
ọrịa shuga na-arịa ọrịa mamịrị.

Banyere nke a ugbu a, ndị sayensị kwuru na ntụkwasị obi zuru oke. Na agbanyeghị, ọ nwebeghị ike ịdabere na usoro iji chekwaa ihe eji edozi ihe a.

N’ezie, enwere nnukwu ọdịiche dị n’etiti nyocha ụlọ ọgwụ na omume. Ya mere, n'ihe gbasara C-peptide, a ka nwere arụmụka na gburugburu ọgwụ. Enweghị ozi ezughi oke na nsonaazụ yana ọghọm nke C-peptide.

Normkpụrụ nke C-peptide n'ime ahụ

Agnochọpụta ọrịa shuga mellitus chọrọ ọtụtụ ọmụmụ. Edere onye ọrịa ahụ nnwale ọbara na mmamịrị maka shuga, ule nnwale na glucose.

Na ọrịa shuga mellitus, mkpebi nke C-peptide n'ime ọbara bụ ihe amanyere.

Enwere nyocha nke nwere ike inyocha ọrụ nke agwaetiti nke Langerhans na pancreas ma gosipụta ọnụọgụ nke homonụ hypoglycemic dị n'ahụ. A na-akpọ ihe ngosipụta a peptide ma ọ bụ C-peptide (C-peptide).

Anụ a na-echere bụ ụdị ebe a na-edobe homonụ protein. A na-echekwa ya ebe ahụ n'ụdị proinsulin. Mgbe mmadụ gbaruru shuga, proinsulin na-emebi ma nwee ọgwụ insulin.

N'okpuru ọnọdụ na ọrịa dị a isaa ka a na-eme nyocha?

Ọrịa nke edepụtara nyocha:

ụdị 1 na ụdị ọrịa shuga 2
ọrịa imeju dị iche iche
polycystic ovary,
etuto ahụ na-egbu mgbu,
ịwa ahụ
Ọrịa Cushing
Nyochaa ọgwụgwọ hormone maka ụdị ọrịa shuga 2.

Ihe kpatara ya bu:

Na mbu, ana - emeju insulin n’ime akwara. Mgbe mmadụ rịrị shuga, homonụ ahụ na-abanye n’imeju. N'ebe ahụ, ụfọdụ n'ime ya edozi, ebe akụkụ nke ọzọ na-arụ ọrụ ya ma belata shuga. Ya mere, mgbe ị na-ekpebi ọkwa nke insulin, ọkwa a ga-adị ala mgbe niile karịa njikọta nke pancreas.
Ebe ọ bụ na mwepụta nke insulin na-apụta mgbe erichara carbohydrates, ọkwa ya na-ebili mgbe erichara nri.
A na - enweta data na - ezighi ezi ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa mellitus na - arịa ọrịa insulin.

Kedu otu esi eme nyocha ahụ?

Nri abalị 8 tupu ị bloodụ ọbara kwesịrị ịdị ọkụ, enweghị nri nwere abụba.

Algorithm nyocha:

Onye ọrịa na-abịa na afọ na-enweghị oghere gaa na ụlọ ịnakọta ọbara.
Nọọsụ na-anara ya ọgwụ ọjọọ.
A na-etinye ọbara n'ime ọkpọkọ pụrụ iche. Mgbe ụfọdụ o nwere gel pụrụ iche ka ọbara ya wee ghara kechie.
Mgbe ahụ, a na-etinye tube ahụ na centrifuge. Ihe a dị mkpa iji wee kewapụ plasma ahụ.
Mgbe ahụ, a na-etinye ọbara ahụ na friza ma jụọ oyi-ogo.
Mgbe nke ahụ gasịrị, a na-ekpebi nha peptide na insulin n'ime ọbara.

Olee ihe si na ya pụta?

Ọmụmụ ihe ahụ na-egosi nsogbu ahụ, yabụ isi iwu bụ idobe nri.

Ndụmọdụ ndị bụ isi maka ndị ọrịa na-enye ọbara na C-peptide:

8 awa ngwa ngwa tupu onyinye ọbara,
ị nwere ike ị drinkụ mmiri na-abụghị carbonated,
ị gaghị a alcoholụ mmanya ụbọchị ole na ole tupu ọmụmụ ihe ahụ,
belata nrụgide anụ ahụ na nke mmetụta uche,
a doụ sịga awa atọ tupu ọmụmụ ihe ahụ.

Ozizi vidio banyere ihe kpatara ọrịa shuga:

N'ọnọdụ dị a isaa ka ọkwa dị n'okpuru nkịtị?

A ga-enye ndị ọrịa agadi na ebumnuche oke ibu oke ụdị shuga 2 na usoro gbagọrọ agbagọ. N'okwu a, a ga-egosi onye ọrịa inle inulin.

Na mgbakwunye, onye ọrịa ahụ chọrọ nyocha ọzọ.

nyocha fundus
na-ekpebi steeti arịa na irighiri akwara nke ala nsọtụ.
mkpebi nke imeju na ọrụ akụrụ.

Mbelata peptide na - emekwa:

mgbe ọwachara akụkụ ahụ nke pancreas,
hypoglycemia artificial, ya bụ, mbelata shuga ọbara nke inje insulin butere.

N'ọnọdụ dị a isaa dị larịị karịa ụkpụrụ?

Nsonaazụ nke otu nyocha agaghị ezu, yabụ ekenye onye ọrịa ọ dịkarịa ala nyocha ọzọ iji chọpụta ọkwa shuga dị n'ọbara.

Ọ bụrụ na C-peptide dị elu ma shuga adịghị, mgbe ahụ, a na-achọpụta onye ọrịa na insulin resistance ma ọ bụ proiabetes.

N'okwu a, onye ọrịa ahụ achọghị ọgwụ insulin tupu ya, mana ọ kwesịrị ngwa ịgbanwe ụzọ ndụ ya. Jụ omume ọjọọ, bido igwu egwuregwu ma rie nri.

Na mgbakwunye, mmụba na C-peptide ga-ekwe omume na:

insulinoma - akwara nke na - eme ka insulinoma hie nne,
insulin iguzogide - a ọnọdụ nke anụ ahụ mmadụ na-atụkwasị uche nke insulin,
polycystic ovary - ọrịa nke nwanyi na - ebute ọrịa ụkwara ara.
odida akwara nke na - egbu egbu - enwere ike ibute ọrịa shuga zoro ezo.

Akwukwo ndi ozo ndi ozo choro

C-peptides na ọrịa shuga: ụdị 1, ụdị 2, ọkwa shuga (ihe ị ga-eme ma ọ bụrụ na ọ dị elu) nyocha, ụkpụrụ, ọgwụgwọ

C-peptides bụ ihe mkpụrụ ndụ beta nke mepụtara na - ewepụta oke insulin n'ime ahụ. Edere nyocha maka C-peptides maka ọrịa shuga mellitus maka nchọpụta ziri ezi nke ụdị (ụdị 1 ma ọ bụ ụdị 2) na ọrịa na-esochi ọrịa shuga.

Gịnị bụ C-peptides

Site na mmụba nke glucose ọbara, pancreas na-eme ka proinsulin ụmụ irighiri ihe na-eme, nke na-enye aka na mbibi ha na insulin na nsị amino acid, nke bụ C-peptide.

N'ihi ya, agịrị nke peptides na - apụta mgbe emepụtara insulin n'ime ahụ. Na elu ọdịnaya nke C-peptides n’ime ọbara, insulin na-arụ ọrụ n’ime ahụ.

Peptide nwetara aha "C" n'ihi na yinye ya bụ otu n'ụdị leta a. Na mbu, udiri insulin na-adi ka gburugburu.

N'ime ọrịa shuga mellitus ma ọ bụ ọrịa imeju, a na-eme nyocha maka C-peptides, n'ihi na mgbe akụkụ ahụ mepụtara, insulin na-agafere imeju, ebe ahụ na-edozi akụkụ ụfọdụ, na-abanye n'ọbara na-ezighi ezi. Ya mere, ọ gaghị ekwe omume ịchọpụta ego ole insulin rụpụtara.

Kedu nyocha

Peculiarities nke nyocha C-peptide maka onye ọrịa adịghị obere na nyocha ọbara biochemical dị na mbụ.

A na-ewepụta ọbara site na akwara iji chọpụta maka peptides, na ebe ọ bụ na nri na-emetụta kpọmkwem mmepụta insulin, a na-enye ọbara na afọ efu. Nri kwesịrị ịbụ awa 6-8 tupu nyocha.

Amachibidoro iwu nyocha:

na-a alcoholụ mmanya
na-ese anwụrụ
were ọgwụ homonụ (ma ọ bụrụ na ha adịghị mkpa maka ahụike),
rie chọkọleti ma ọ bụ ụdị ụtọ ndị ọzọ.

Mgbe ụfọdụ nyocha banyere afọ efu anaghị enye data ziri ezi, yabụ dọkịta depụtara usoro ndị na-akpali akpali maka nsonaazụ nyocha ọhụụ. Usoro ndị a gụnyere:

nri ụtụtụ nke nwere carbohydrates dị mfe (achịcha ọcha, mpịakọta, achịcha), nke na-abawanye mmepụta insulin na, ya mere, C-peptides,
Ọkpụkpụ glucagon bụ ọgwụ mgbochi insulin (a machibidoro ya usoro maka ndị nwere ọbara mgbali elu), ọ na-eme ka ọkwa glucose dị n'ọbara.

Onye ọrịa ahụ natara nsonaazụ ahụ ihe na-erughị awa 3 mgbe ịbịnye ọbara. Oge a nwere ike ịbawanye elu, ebe ọ bụ na emeghị nyocha nke C-peptide na ụlọ nyocha niile na-adakarị ma enwere ike ibuga ya na ebe nyocha ka ama ama. Oge nchere ọkọlọtọ bụ ụbọchị 1-3 site na ụbọchị nyocha.

N’ụbọchị nyocha, ịhapụ ị usingụ ọgwụ niile. Ọ bụrụ na ọjụjụ a na-eyi ndụ egwu ma ọ bụ ahụike, ọ dị mkpa ịkpọtụrụ dọkịta depụtara ọgwụ ndị a.

Ọdịnaya nkịtị

aru
afọ
ọrịa na-adịghị ala ala
ọrịa dị iche iche (ARVI, Influenza),
eto eto homonụ.

Ọkwa dị elu

A na-abawanye ọkwa ma ọ bụrụ na ihe ngosi ahụ karịrị 0.63 mol / l (karịa 7.1 ng / ml). A na-ahụ ọkwa dị elu nke peptides na:

ụdị 1 na ụdị ọrịa shuga 2
adrenal dysfunction,
imebi usoro endocrine,
oke ibu (oke ibu),
akpachaghị anya homonụ (n'ime ụmụ nwanyị na iji ọgwụ mgbochi),
homonụ (na nwoke nwoke n'oge nwoke na-eto eto),
insulinoma (nguzozi ojoo),
Ọrịa pancreatic
cirrhosis nke imeju.

Obere dị ala

A na-ebelata ọkwa C-peptides ma ọ bụrụ na ihe ngosi ahụ erughị 0.26 mol / l (erughị 0.9 ng / ml).

Ọdịnaya peptide dị ala na-egosi nsogbu nke ụdị ọrịa shuga 1 dị ka:

ọrịa mamịrị retinopathy (arịa arịa anya retina),
arụ ọrụ nke akụkụ akwara ozi na akwara ọbara nke ụkwụ (ihe ọghọm nke ibute gangrene na ibepu nke nsọtụ ala)
pathology nke akụrụ na umeji (nephropathy, ịba ọcha n'anya),
ọrịa mamịrị (ọrịa mamịrị) (ntụpọ ọbara ọbara ma ọ bụ papules nwere dayameta nke 3-7 cm na ụkwụ).

Ọrụ nke peptides na ọrịa shuga

Nnyocha nke endocrinologists nke C-peptides na-egosi abamuru nke amino acid yinye, nke na-eme ka ọnọdụ ndị ọrịa mamịrị dịkwuo mma. Site na nhazi nke C-peptides na insulin na ndị ọrịa nwere ọrịa mellitus, a na-ahụ mgbanwe dị mma, dịka:

mbelata na ugboro nke ọrịa nephrosis (mbibi akụrụ na mgbanwe ọrịa na akụrụ gbasara akụrụ),
ihe ọghọm nke neuropathy (mmebi akwara na-abụghị mbufụt),
ọdịmma,
ibelata ugboro ugboro nke ọgụ.

Ya mere, peptides na-arụ ọrụ metụtara iwu insulin dị na ahụ, ịdị ọcha ha ga-enyere aka melite ọnọdụ onye ọrịa.

Mkpa nyocha maka C-peptides dị mkpa maka:

Nkọwapụta ụdị ọrịa shuga.
Nhọrọ ziri ezi nke ọgwụ na usoro ọgwụgwọ.
Chọpụta erughị erule sel.
Nyochaa ọnọdụ onye ọrịa mgbe mwepu pancreas gasịrị.

Ntụle tozuru oke nke C-peptides nwere ike inye ozi karịa ọmụmụ ndị ọzọ nke anụ ahụ na insulin.

C peptide: nyocha, iwu, nyocha

C (C) peptide, ma ọ bụrụ na ị sụgharịa aha ahụ n'asụsụ Bekee, pụtara peptide njikọ. Ọ na-egosi ọkwa nke nzuzo ma bụrụkwa ihe na-egosi ọrụ arụ ọrụ akwara. Mkpụrụ ndụ ndị dị n’elu dị mkpa iji mepụta insulin.

Mkpụrụ Peptide na Ọrịa Shuga

Ndị ọkachamara n'ịgwọ ọrịa n'oge a kwenyere na nyocha nke peptide na-aza ajụjụ banyere ọdịnaya insulin zuru oke karịa nyocha nke insulin. Enwere ike ịkpọ nke a otu uru dị na nyocha a.

Uru nke abụọ bụ na nyocha dị otú a na-eme ka ọ dị mfe ịchọpụta ọdịiche dị n'etiti insulin na-agwụ aghara na endogenous. A kọwara nke a site n'eziokwu ahụ bụ na C - peptide enweghị mmeghachi omume na ọgwụ mgbochi insulin ma enweghị ike ibibi ha.

Ebe ọ bụ na ọgwụ enweghị ọgwụ peptide n’ime ihe mejupụtara ha, nyocha ahụ ga-eweta ozi gbasara arụmọrụ mkpụrụ ndụ beta n’ahụ mmadụ. Echefula na ọ bụ mkpụrụ ndụ beta na-ahụ maka mmepụta nke insulin endogenous.

Ọ bụrụ na mmadụ na-arịa ọrịa shuga, nnwale C - peptide ga-enye ozi maka ịdịmma na nguzogide anụ ahụ na insulin.

Ọzọkwa, dabere na nyocha ahụ, ọ ga-ekwe omume ikpebi usoro mgbaghara, ozi a ga - enyere gị aka ịhazi usoro ọgwụgwọ dị mma. Site na ịba ụba ọrịa shuga mellitus, ọkwa nke peptide n'ime akwara ọbara ga-adị ala karịa. Ya mere, enwere ike ikwubi na insulin na -akasị ahụ n'ahụ ezughị.

Ọ bụrụ n’iburu n'uche ihe niile a dị n’elu, ị nwere ike inyocha ọkwa nke insulin na-emetụta ọnọdụ dị iche iche. Ọ bụrụ na onye ọrịa ahụ nwere ọgwụ mgbochi ọgwụ insulin, n'ọnọdụ ụfọdụ, enwere ike ịbawanye ọkwa nke C - peptide. A kọwara nke a site na mmekọrịta nke sel na proinsulin.

Ọ dị ezigbo mkpa ị attentiona ntị na ntinye uche nke C - peptide n'ime akwara ọbara mgbe a rụchara insulinoma. N'okwu a, ụba ọdịnaya nke peptide ihe na-egosi nlọghachi nke tumo nke ihe ojoo ma ọ bụ usoro nke metastasis. Echefula na ọkwa nke C - peptide nwere ike ịdị iche na nke a na-enwe n'ọgba aghara na akwara ma ọ bụ akụrụ.

Kedu ihe kpatara ọmụmụ banyere C - peptide ji dị mkpa?

Nyocha ahụ ga-ekpebi ụdị ọrịa shuga.

Nyocha ahụ ga - enyere aka ikpebi usoro ọgwụgwọ.

Kpebie usoro onodu ogwu gi.

Nchịkọta ahụ ga-eweta ozi maka ọdịnaya nke mkpụrụ ndụ beta n’ime pancreas,

Ozi gbasara ogo njikọta insulin na-egosi.

You nwere ike ijikwa C peptide mgbe mwepụ nke pancreas gasịrị.

Kedu ihe kpatara C peptide?

N'ime oge dị anya, ndị ọkachamara n'ịgwọ ahụike rụrụ ụka na ahụ adịghị eji ihe peptide eme ihe n'ụzọ ọ bụla ma ndị dọkịta chọrọ naanị peptide iji chọpụta nsogbu ọrịa shuga mellitus.

N'oge na-adịbeghị anya, ndị ọkachamara n'ịchọpụta ahụike achọpụtala na iji ọgwụ peptide na insulin na-ebelata ihe ize ndụ nke ịmalite ọrịa shuga, ya bụ, neuropathy, angiopathy na nephropathy.

Arụ ụka arụmụka ka na-aga n'ihu n'okwu a. A kọwara nke a site n'eziokwu ahụ bụ na egosipụtaghị na ọgbụgba aka nke ihe peptide na-akpata ihe na-ebute nsogbu. Ugbu a, nke a ka bụ ihe dị ịtụnanya.

Ọ bụrụ n’ịchọpụta ọrịa shuga, ekwenyeghị na ọgwụgwọ ozugbo iji otu ntụtụ, nke ndị mmadụ na-abụghị ndị ọkachamara ahụike zuru oke na-enye. Ọ bụ dibia bekee ga-enyocha usoro usoro ọgwụgwọ niile.

May nwekwara ike ịchọta isiokwu bara uru na isiokwu a:

Gịnị bụ C peptide?

Enwere ike tụọ ọnụọgụ nke C-peptide na-adabaghị n'ime ọbara na insulin site na iji usoro nchọpụta pụrụ iche. Tụnyere mkpebi siri ike insulin na-eme, ọmụmụ a nwere uru nke ukwuu na-egbochi nkwụsi ike nke mmiri ọgwụ. Ta c-peptide na-arụkọ ọrụ na ọkwa insulin.

Na mgbakwunye na uru nchọpụta ya, C-peptide nwekwara mmetụta nke ya na metabolism cell dịka nsonaazụ ọhụụ mere. Ọ na - ekekọta ndị na - anabata ya na G-protein na akpụkpọ ahụ nke sel dị iche iche (neurons ma ọ bụ mkpụrụ ndụ endothelial) ma si otu a na - arụ ọrụ ụzọ mgbaàmà intracellular. N'ime omumu ihe omumu nke umu anumanu na-arịa oria 1, ochichi nke C-peptide ka aruputara oru oma nke akwara na akara nke neuropathy mamria.

Nnwale ọbara C-peptide: gịnị kpatara o ji dị mkpa?

A na-eji C-peptide achọpụta ọrịa shuga mellitus na akpụ na-emepụta insulin. C-peptides na-enyere aka ikpebi ihe kpatara hypoglycemia.

Ọtụtụ ndị na-ajụ: gịnị ka nyocha a gosipụtara? C-peptide na insulin bụ ụdọ peptide guzobere site na ịgbalite na ike nke proinsulin (ihe na - agbanye insulin n'oge na - adịghị arụ ọrụ). Mgbe ahụ ahụ́ chọrọ insulin, a na-ahapụ ya ka ọ banye n'ọbara iji mee ka glucose (dị ka ihe akụrụngwa maka ike) gaa na sel nke anụ ahụ, ebe ana-ahapụ sọha C-peptide n'otu oge.

Enwere ike iji nyocha C-peptide ọbara nyochaa nyocha nke insulin endogenous insulin (nke insulin na-emepụta site na mkpụrụ ndụ B n’ahụ). Dika odi, ana enweta obara obara site na akwara nke brachial. Ọ bụrụ na achọrọ elekere iri abụọ na anọ, a ga-anakọta mmamịrị n'ime awa iri abụọ na anọ.

Peptides na ọgwụgwọ ọrịa shuga

GLP-1 bụ homonụ nke emepụtara na sel pụrụ iche nke mucosa eriri afọ. A na-ahapụ homonụ ahụ mgbe ị risịrị nri - ọkachasị mgbe ị gluụchara glucose. Ọ na - arụ ọrụ na sel sel islet nke pancreas ma nwee mmetụta okpukpu abụọ:

Na-eme ka mmiri ọgwụ insulin na-arụ ọrụ site na mkpụrụ ndụ pancreatic B
Ọ na -ebelata ọnụego glucagon synthesis, nke a na-emepụta n’ime akwara ndị na - eme ka ọ bụrụ ọgwụ insulin.

E gosiputara na polypeptide insulinotropic polypeptide (HIP) enweghị mmetụta na-akpali akpali na mwepụta nke insulin na shuga dị elu. GLP-1 adịchaghị arụ ọrụ n’arịa ọrịa mamịrị karịa n’ozi ndị ahụ siri ike. Agbanyeghị, GLP-1 tụgharịrị bụrụ ihe akwụghị chịm mgbe ejiri ya dịka ọgwụ n'ihi mbibi nke dipeptidyl peptidase 4 site na enzymes na, ya mere, adịteghị aka.

Egosipụta Exenatide belatara oke ahụ. Na mgbakwunye, achọpụtara na ọgwụgwọ ogologo oge yana incretin mimetics na IDDP-4 nwere ike ichebe sel beta na mmebi. Mmetụta nke klas abụọ nke ọgwụ na-adaberekwa n'ọkwa glucose dị n'ọbara. Mgbe ị na-a theụ ọgwụ, hypoglycemia dị ụkọ.

N'ihi ọgwụ a, a na-ahapụ insulin ọzọ, ọ nwere ike ịnọ ogologo oge. Peptide eke ahụ na-ekpocha ihe dị ka nkeji 1 ruo 2 na enzyme dipeptidyl peptidase-4. Ya mere, GLP-1 nwere ike ime ihe obere oge. Iji mee ka ọrụ GLP-1 dị ogologo, e mepụta ọgwụ ndị na-egbochi enzyme mbibi ahụ DPP-4. Ọgwụ ndị a gụnyere sitagliptin na vildagliptin, nke akpọkwara DPP-4 inhibitors.

Enwere ike iji ọgwụ ọjọọ naanị ma ọ bụrụ na onye ọrịa emee insulin nke insulin zuru oke. Nsonaazụ dabere na nri. Maka nke a, ndị na - egbochi ihe adị anaghị ebute hypoglycemia. Ihe ize ndụ nke hypoglycemia dị ala ma e jiri ya tụnyere ndị ọzọ na-agwọ ọrịa antidiedi.

Ọgwụ ọjọọ dị n’otu a na-anabata nke ọma ma nwee mmetụta ole na ole. Ha na-eduga n'ibelata afọkwa na afọ iri nri. N'ihi ya, ha anaghị ebute ịba ụba. Ihe ize ndụ nke hypoglycemia dị obere. Patientsfọdụ ndị ọrịa nwere imi, akpịrị, isi na ahụ mgbu, na ọnya afọ. E bipụtabeghị ihe ọmụmụ ndidi ogologo oge.

Ọgwụ peptide ọgwụ ndị a na-eji maka shuga:

Liraglutide: Na July 2009, akwadoro ọgwụ maka ọgwụgwọ nke oke ibu na ọrịa shuga. Oge ihe a dị ruo awa iri abụọ na anọ,
Exenatide: A rụrụ polypeptide n'ụkpụrụ nke exendin-4 dị na asịrị nke azụ azụ nke Arizona. N'April 2005, United States kwadoro mkpebi iji ọgwụ ahụ yana mgbakwunye metformin ma ọ bụ glitazones. A na-eji ọgwụ ahụ eme ihe n’ụdị ọgwụ mgbochi kwa izu.
Albiglutide: anọwo na ahịa dị na Russia kemgbe Ọktoba 2014. Anabatara ya maka monotherapy oria,
Dulaglutide: rere ya na ahịa ọgwụ Russia kemgbe ọnwa Febụwarị 2015. Usoro onunu ogwu bukwara kwa izu,
Taspoglutide: a mepụtara analogue nke GLP-1 na njedebe nke 2009. Na Septemba 2010, Roche kwupụtara na a kwụsịrị ọmụmụ ihe niile ya na ọgwụ ahụ. Ihe kpatara nke a bụ ezigbo ihe nfụkasị ahụ na mmeghachi omume na-egbu oge na eriri afọ, ọkachasị ọgbụgbọ na ọgbụgbọ.

Ọnụ ego ọgwụ ọjọọ dịgasị iche iche: site na 5,000 ruo 32,000 rubles.

Ndụmọdụ! Ekwesịrị ịgwọ ọgwụ iji belata shuga ọbara dị ka ọgwụ ndị dọkịta nyere si dị. Ọ bụrụ na mgbaàmà nke hypoglycemia (shuga dị ala) kwa oge na-apụta, a na-atụ aro ka ị gwa dọkịta gị. A naghị atụ aro nwatakịrị ahụ ị drugsụ ọgwụ ndị a dị n'elu, ebe ọ bụ na emebeghị nnyocha ụlọ ọgwụ na ụmụaka.

Peptides na-arụ ọrụ dị mkpa na nhazi nke glycemia. N'ime usoro ọgwụgwọ, a na-eji ha dị ka ọgwụ na biomarkers nke ọrịa dị iche iche. A na-atụ aro ka ị were ọgwụ ahụ naanị n'okpuru nlekọta dọkịta, ọ bụrụkwa na mgbaàmà na-adịghị mma yana mgbaàmà dị ize ndụ, ị kwesịrị ịkpọtụrụ onye ọkachamara ọkachamara iji gbochie nsogbu ọ bụla enwere ike.