Ntuziaka maka glimekomb - (Glimekomb) maka ojiji

Sdị usoro onunu ogwu - mbadamba nkume: cylindrical, si na-acha ọcha ruo ọcha na kema ma ọ bụ odo odo (agba marbling ga-ekwe omume), na njiri mara mma na bevel (PC 10. Na ngwugwu nke mkpụrụ ndụ contour, na igbe kaadiboodu 6 ngwugwu, ngwugwu 20) Na ngwugwu blisters, na ngwungwu ngwugwu 5 ngwugwu, 30, 60 na PC abụọ na karama plastik, na ngwugwu kaadiboodu 1).

Ihe dị n'ime 1 mbadamba:

• metformin hydrochloride - 500 mg,
• gliclazide - 40 mg.

Ihe ndi ozo: sodium croscarmellose, povidone, magnesium stearate, sorbitol.

Ihe ngosi maka ojiji

• ụdị 2 ọrịa shuga mellitus bụrụ na enweghi ike nke usoro ọgwụgwọ nri, arụ ọrụ anụ ahụ na monotherapy gara aga na gliclazide ma ọ bụ metformin,
• ụdị shuga abụọ ọrịa shuga na -eme ka ọ̀tụ̀tụ̀ glucose ọbara na-achịkwa nke ọma - iji dochie ọgwụ ịchikota gara aga na ọgwụ abụọ (gliclazide na metformin).

Ihe ngbanwe

• hypoglycemia,
• ọrịa mamịrị ketoacidosis, precca mamịrị shuga,
• ụdị shuga 1
• imeju imeju
• ọrịa na-adịghị ala ala na hypoxia anụ ahụ: infarction myocardial na-adịbeghị anya, akụkụ okuku ume na nkụchi obi, ujo,
• Ọnọdụ ọjọọ nke pụrụ iduga n'ịrụ ọrụ akụrụ: ọrịa na-efe efe, akpịrị ịkpọ nkụ, ujo,
• oke nrụrụ akụrụ
• lactic acidosis, gụnyere akụkọ ihe mere eme nke
• ọrịa na-efe efe, oke ọkụ, mmerụ ahụ, nnukwu ịwa ahụ na ọnọdụ ndị ọzọ chọrọ ọgwụgwọ insulin.
• porfria
• nnukwu mmanya mmịnya, mmanya na-egbu egbu,
• rube isi na obere kalori (na-erughị calorie 1000 / ụbọchị),
• oge ime na inye nwa ara,
• na-eme nyocha nke radioisotope ma ọ bụ X-ray na ntinye nke ayodiin nwere ihe dị iche (48 awa tupu yana 48 awa mgbe ọ gasịrị),
• ojiji nke miconazole,
• hypersensitivity na ọgwụ ọ bụla na-arụ ọrụ ma ọ bụ nke inyeaka nke ọgwụ ma ọ bụ ihe ndị ọzọ na-eme ka sulfonylurea.

A naghị akwado Glimecomb maka ndị ọrịa karịrị afọ 60 ndị na-arụ ọrụ anụ ahụ dị ukwuu (n'ihi nnukwu ihe ize ndụ nke ịmalite ọrịa lactic acidosis).

• ọrịa thyroid na imebi ọrụ ya,
• adrenal ezughi ezu,
• ọrịa febrile
• hypofunction nke akụkụ ahụ ike ihu.

Usoro onunu ogwu na nhazi

Ekwesịrị iji ọnụ glimecomb mgbe a risịrị nri ma ọ bụ ozugbo nri.

Dọkịta na-ekpebi ọgwụ n’otu n’otu, dabere n’ogo glucose dị n’ọbara.

Ọgwụ mbụ kwa ụbọchị, dịka iwu, bụ mbadamba 1-3, mgbe ahụ ọ na-eji nwayọ nwayọ, ma ọ bụrụ na ọ dị mkpa, ruo mgbe enwere ike ịkwụ ụgwọ nkwụghachi nke ọrịa ahụ.

Oke kachasị kwa ụbọchị bụ mbadamba ise.

A na-ekekarị ụbọchị kwa ụbọchị ụzọ abụọ - ụtụtụ na mgbede.

Nsonaazụ

• mmeghachi omume nfụkasị ahụ: akwara na - akpachapụ anya, itching, urticaria,
• site n'akụkụ nke metabolism: na nri na-ezighi ezi na mmebi nke usoro dosing - hypoglycemia (agụụ, isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ọgbụgbọ, mmụba ịba ụba, nsogbu akwara ozi na-adịru nwa oge, njikwa nkwonkwo nke mmeghari, palpitations, na ọganihu nke hypoglycemia - ọnwụ nke njide onwe onye na nsụhọ) , n'ọnọdụ ụfọdụ - lactic acidosis (mgbu azụ, nsogbu nke akụkụ iku ume, wedata ọbara mgbada, ụra, myalgia, adịghị ike, hypothermia, reflex bradyarrhythmia),
• site na akụkụ ahụ haemopoietic: adịkarịghị - mgbochi nke ụmị ọkpụkpụ (thrombocytopenia, anaemia, leukopenia),
• site na nri digestive: ọnwụ nke agụụ, ọrịa dyspeptik (ụtọ ọla na ọnụ, afọ ọsịsa, ọgbụgbọ, mmetụta nke oke ibu na epigastrium), adịkarịghị - mmebi imeju (ịba ụba ọrụ nke ọrịa hepatic na alkaline phosphatase, cholestatic jaundice, ịba ọcha n'anya),
• Ndị ọzọ: enweghi ike ịhụ ụzọ.

Ngwurugwu nke sulfonylureas, nke nwere otu n'ime ihe ndị na - arụ ọrụ nke Glimecomb (glyclazide), nwere ike ibute nsonaazụ ndị a: vasculitis nfụkasị, ọrịa hemolytic, agranulocytosis, pancytopenia, erythropenia, na ọrịa imeju na-eyi ndụ egwu.

N'ihe banyere ịdoụbiga mmanya ókè na ọnụnọ nke ihe ndị dị ize ndụ n'ihi metformin nke bụ akụkụ nke ọgwụ ahụ, mmepe nke lactic acidosis ga - ekwe omume - ọnọdụ chọrọ nlekọta ahụike mberede (akọwapụtara ihe mgbaàmà ya n'elu). Ekwesịrị ịmalite ọgwụgwọ n'ụlọ ọgwụ. Treatmentzọ kachasị dị irè maka nsogbu a bụ ịba ọcha n'anya.

Ọzọkwa, ịdoụbiga mmanya ókè nwere ike ibute mmepe nke hypoglycemia, ebe ọ bụ na gliclazide bụ akụkụ nke ọgwụ. Site na ịdị nro nke hypoglycemia dị nro, a ga-achịkwa glucose (dextrose) ma ọ bụ jiri shuga mee ihe iji gwọọ ya ọnụ. Na nnukwu hypoglycemia (nke e gosipụtara site na mmụọ ịmara) ihe 40% glucose (dextrose) na-abanye n'ime intravenously, subcutaneously ma ọ bụ intramuscularly glucagon. Mgbe onye ọrịa ahụ mechara nwetaghachi mmụọ, ọ dị mkpa inye ya nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Ntụziaka pụrụ iche

A na-enye Glimecomb naanị maka ndị ọrịa na-anata nri mgbe nri nwere obere carbohydrate, nke gụnyere nri ụtụtụ.

N'oge ọgwụgwọ, ị kwesịrị ị na-enyocha ọkwa nke glucose n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri, karịsịa n'ụbọchị mbụ ị takingụ ọgwụ ahụ.

Ekwesịrị ịkwụsị Glimecomb awa iri anọ na asatọ tupu nchịkwa ọgbụgba nke radioineine nwere ọgwụ iodine ma ọ bụ ịwa ahụ. Inwere ike ịmaliteghachi were oge tupu 48 awa.

Ekwesiri iburu n'uche na ihe ndị a na - emepụta sulfonylurea (n'ọnọdụ a, glyclazide) nwere ike ibute hypoglycemia, n'ọnọdụ ụfọdụ n'ụdị siri ike ma dịte aka. Ọtụtụ mgbe, ọnọdụ a na - ebilite site na nri nwere obere kalori, mgbe ike gbasiri ike ma ọ bụ ogologo oge, mgbe ị drinkingụ mmanya na-egbu egbu, yana mgbe ị na - ewere ọtụtụ ndị ọrịa hypoglycemic. Iji zere mmepe nke hypoglycemia, ọ dị mkpa iji nlezianya họrọ otu maka onye ọrịa ọ bụla ma nye ya ozi zuru ezu banyere ọgwụgwọ na-abịanụ.

O kwesiri imeghari uzo Glimecomb ga-agbanwe mgbe ị na-agbanwe nri, ya na nrụgide mmụọ na nke anụ ahụ.

Ndị otu ndị ọrịa nwere ndị na-esote na-ahụkarị ọrụ nke ọgwụ hypoglycemic:

• ndị ọrịa na-enweghi ike ọgbụgba
• ndị agadi
• ndị na-anaghị enweta nri edozi,
• ndị ọrịa nwere ọnọdụ adịghị ike.

Agụụ na-egbu egbu, mmanya na ọgwụ mgbochi na-abụghị steroidal na-abawanye ihe ize ndụ nke hypoglycemia.

Guanethidine, reserpine, clonidine na beta-blockers nwere ike kpuchie akara nke ọgwụ hypoglycemia.

Na ọrịa na-efe efe na ọrịa febrile syndrome, oke ọkụ, mmerụ ahụ na nnukwu ịwa ahụ, ịkagbu Glimecomb na ịhọpụta ọgwụ insulin. N'oge usoro ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ akụrụ na oge (ọbụlagodi ugboro 2 n'afọ) na-ekpebi lactate na plasma. N'ihe banyere lactic acidosis, ọ dị mkpa ịkagbu ọgwụ ahụ.

Mgbe ị na-eme atụmatụ ịtụrụ ime na ihe omume ya oge a na-a theụ ọgwụ, ọ dị mkpa ịkwụsị ị andụ ọgwụ ọgwụ insulin.

Amachibidoro ị alcoholụ mmanya na-aba n'anya. Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala ma na-arụ ụdị ọrụ dị ize ndụ nke chọrọ nlebara anya, ọsọ nke mmeghachi omume nke uche na moto.

Mkparịta ụka ọgwụ ọjọọ

Mmetụta hypoglycemic nke Glimecomb na-eme ka hypoglycemic ndị ọzọ dịkwuo elu (dịka, insulin, acarbose, biguanides), ndị na-egbochi ihe nzuzo nke tubular, sulfonamides na-arụ ọrụ ogologo oge, ndị na-egbochi N₂histamine ihe nnabata-akụ ọkpọ (e.g. cimetidine), coumarin anticoagulants, antifungal elekọta mmadụ (fluconazole, miconazole), Ace inhibitors (enalapril, captopril), beta-blockers, salicylates, ndị so ná ndị mgbochi mkpali ọgwụ ọjọọ (oxyphenbutazone, azapropazone, phenylbutazone), monoamine oxidase inhibitors , ọgwụ mgbochi TB (ethionamide), fibrates (clofibrate, bezafibrate), anabolic steroids, oxytetracycline, fenfluramine, na-enupụ isi, tetracycline, guanethidine, fluoxetine, c cyclophosphamide, allopurinol, reserpine, chloramphenicol, pyridoxine, theophylline, pentoxifylline, bromocriptine.

Hypoglycemic edinam Glimekomba imeda carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, lithium, mgbochi akwụkwụ ọgwụ (phenytoin), thyroid homonụ blockers ngwa ngwa calcium ọwa, Steroid, barbiturates, agonists (epinephrine, clonidine), rifampicin, baclofen, chlorthalidone, diazoxide, furosemide, glucagon, isoniazid, triamteren, terbutaline, morphine, asparaginase, salbutamol, danazol, ritodrin, na oke onunu ogwu - mgbochi ura, estrogens, chlorpromazine, nicotine hydrochloric acid.

Ọgwụ ndị na-egbochi ụmị ọbara hematopoiesis na-amụba ohere nke myelosuppression, ethanol - mmepe nke lactic acidosis.

N'ihe banyere ijikọ ya na glycosides cardiac, Glimecomb na-abawanye n'ihe ize ndụ nke extrasystole ventricular.

Nifedipine na - akwalite mmịpụta ma na - eme ka ikpochapu metformin kwụsị.

Site na iji ogologo oge, ndị na-eme ka cationic zoro ezo na tubules (procainamide, amiloride, vancomycin, quinine, quinidine, digoxin, triamteren, morphine, ranitidine) na-abawanye oke nke metformin n'ọbara site na 60%, furosemide - site na 22%.

Metformin na-ebelata oke ịta na ọkara ndụ nke furosemide site na 31 na 42.3%, otu isi.

Leasedị mwepụta, nkwakọ na ihe mejupụtara Glimecomb ®

Mbadamba sitere na ọcha ruo ọcha nwere ude ma ọ bụ odo na-acha odo odo, cylindrical ewepụghị, yana chamfer na ihe ize ndụ, a na-anabata marbling.

Ndị pụrụ iche: sorbitol, povidone, ssumum croscarmellose, magnesium stearate.

10 PC - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Ngwakọta ọgwụ hypoglycemic ejikọtara ọnụ maka iji ọnụ mee ihe. Glimecomb® bụ ngwongwo abụọ nke ndị na-eme ọnụ hypoglycemic nke otu biguanide na otu sulfonylurea.

Ọ nwere palọ na extrapancreatic edinam.

Glyclazide bụ usoro sitere na sulfonylurea. Na-akpali mmiri ọgwụ insulin site na pancreas, na-eme ka ahụrịị anụ ahụ na-emetụta insulin. Na-akpali ọrụ nke enzymes intracellular - muscle glycogen synthetase. Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ, na --belata oge dị iche site na oge iri nri na mmalite insulin insulin, ma belata hyperglycemia postprandial. Na mgbakwunye na emetụta metabolism metabolism, ọ na - emetụta microcirculation, na - ebelata nrapado platelet na nchịkọta, na - egbu oge mmepe nke parietal thrombosis, na - egbochi vaskụla permeability ma na - egbochi mmepe microthrombosis na atherosclerosis, na - eweghachi usoro nke physiological parietal fibrinolysis, ma na - anata akwara mbuba. Na-eme ka mmepe nke ọrịa mamịrị na-arịa ọrịa retinopathy na-abụghị nke na-aba ụba, na-arịa nephropathy na-arịa ọrịa ogologo oge, a na-ahụta mbelata dị ukwuu na proteinuria. Ọ naghị ebute mmụba n’arụ ahụ, n’ihi ọ nwere mmetụta kachasị ukwuu na mmalite nke insulin insulin ma ghara ịkpata hyperinsulinemia, na-enyere aka belata oke ahụ n'ahụ ndị ọrịa buru ibu, na-agbaso nri kwesịrị ekwesị.

Metformin bụ otu nke biguanides. Ọ na --ebelata mkpụkọ glucose n'ime ọbara site na igbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na ngụgụ nri ma na - abawanye uru ya na anụ ahụ. Ọ na-ebelata ịta nke triglycerides, cholesterol na LDL (kpebisiri ike na afọ efu) na ọbara ọbara na adịghị agbanwe ntinye uche nke lipoproteins nke ịdị iche iche. Ọ na - enyere aka ịgbatị ma ọ bụ belata ahụ. Na enweghị insulin n'ime ọbara, a naghị egosipụta mmetụta ọgwụgwọ. Ọkpụkpụ hypoglycemic anaghị akpata. Ọ na - eme ka akwara fibrinolytic dị n'ọbara n'ihi mkpesa nke onye na - egbochi nnabata profibrinolysin (plasminogen) ụdị anụ ahụ.

Mmegha nke otu nosological

Mlọ ọgwụ

Mgbu na nkesa

Mgbe nchịkwa ọnụ gasịrị, mmịcha dị elu. Mgbe ewere ya na ọgwụ nke 40 mg C max na plasma ọbara ruru mgbe awa 2-3 gachara 2-3 μg / ml. Ihe mgbochi protin Plasma bụ 85-97%.

Metabolism na ntụpọ

Metabolized na imeju. T 1/2 - 8-20 awa 9. Ọ bụ n’arụ dị ka ụdị metabolites site na akụrụ ya - 70%, site na eriri afọ - 12%.

N'ime ndị ọrịa agadi, anaghị ahụ mgbanwe mgbanwe dị ukwuu na ọgwụ ọgwụ.

Mgbu na nkesa

Mgbe nchịkwa ọnụ gachara, mmịpụta ahụ bụ 48-52%. Anọrọ ngwa ngwa si na nri diges. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%. C max na plasma ọbara ruru ka 1.81-2.69 h ma ọ gafere 1 μg / ml. Ceptionnabata nri na-ebelata C max na plasma site na 40% ma belata ọganiizu ya na nkeji 35. Mgbakwunye protein Plasma bụ nke ileghara anya. Metformin nwere ike ịgbakọta na mkpụrụ ndụ ọbara uhie.

T 1/2 bụ awa 6.2. Ọ bụ akụrụ na-apịpụta ya, ọkachasị adịghị agbanwe agbanwe (ihe nhicha na ngwakọta nke mmiri) na site na eriri afọ (ihe ruru 30%).

Ọnụ ahịa ahịa ọgwụ na Moscow

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Asambodo ndenye aha Glimecomb ®

• LSR-009886/09

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

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Mgbe ị na-ehota ihe ederede nke edepụtara na ibe saịtị ahụ: www.rlsnet.ru, njikọ ga-enweta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Ngwa

A na-atụ aro Glimecomb maka ndị ọrịa nwere ọrịa shuga nke ụdị shuga 2. Ọ dị mkpa na ọgwụ a na-ezubere ụdị ụdị ọrịa a mgbe ọrụ mmega ahụ na maapụ nri ahaziri iche anaghị ewetara nsonaazụ kwesịrị ekwesị. Nke a pụtara na edepụtara ọgwụ a ka ọ bụrụ na enwere usoro ọgwụgwọ siri ike na-aga nke ọma, na ijikọ ọgwụ abụọ (ọtụtụ oge iche na metformin na gliclazide) yana mmega ahụ na nri.

N'oge ọgwụgwọ a na-eji Glimecomb, nlele oge niile maka ọkwa shuga ọbara nke onye ọrịa tupu nri ma mgbe ọ gachara nri dị mkpa (ekwesịrị ị attentiona ntị na izu mbụ nke nnabata).

Dị Mwepụta

Glimecomb nwere otu mpempe akwụkwọ n'ụdị mbadamba ihe. A na-ekewa ọgwụ ahụ site na iji otu esi eme ihe na otu ndị a:

• na karama plastik na ngwugwu kaadiboodu. Otu vial a nwere ike ịnwe mbadamba 30, 60 ma ọ bụ 120,
• N’ime kaadiboodu tinyere blisters nke mbadamba 10 n’ime otu. Otu ngwugwu nwere blisters 6,
• N’ime kaadiboodu tinyere blisters nke mbadamba 20 n’ime otu. Otu ngwugwu dị otú ahụ nwere 5 blisters.

Mbadamba ndị ahụ n’onwe ha dị n’ụdị cylinder dị larịị, ọtụtụ mgbe ọcha (beige, marble ma ọ bụ odo na-anakwere). Erere nwere ihe egwu na bevel. Ihe mejupụtara nke Glimecomb gụnyere metformin na hydrochloride na ego nke 500 mg, yana glycoslide 40 mg. Na mgbakwunye, povidone, magnesium stearate, sorbitol na sodium croscarmellose dị na ntakịrị.

Ihe ngosi nke ogwu Glimecomb ®

• ụdị 2 ọrịa shuga mellitus (nke na-abụghị insulin) na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na ọgwụgwọ mbụ na metformin ma ọ bụ gliclazide,
• dochie usoro ọgwụgwọ gara aga site na ọgwụ abụọ (metformin na gliclazide) na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa mellitus (na-abụghị insulin) na ọkwa glucose ọbara dị mma.

Ntụziaka maka ojiji

Glimecomb ji ọnụ mee ya, ozugbo ị risịrị nri ma ọ bụ soro ya, dabere na usoro onunu ogwu. Mgbe ị na-eji mbadamba ọgwụ eme ihe, ị kwesịrị ịrapara na obere nri carb ndị ọkachamara tụrụ aro ya, nke ga-agụnye nri ụtụtụ. Ọgwụ mbadamba ọrụ kwesịrị iburu n'uche ọ bụghị naanị ogo nke ọrịa shuga mellitus nke ụdị nke abụọ, kamakwa ọnọdụ mmetụta uche na nke anụ ahụ nke onye ọrịa. Ọzọkwa, mgbanwe ọ bụla na nri chọrọ ka ya na dọkịta jikọọ ọnụ (a naghị anabata oke ọnụ na ị fastingụbiga mmanya ókè). Ọ dị mkpa iji chekwaa ọgwụ a kpọrọ nkụ, ebe gbara ọchịchịrị na-adịghị elu karịa ogo 25 Celsius. Ndụ shelf afọ 2.

Ekwesịrị icheta na ngwaahịa sulfonylurea dị na ọgwụ ahụ nwere ike ibute hypoglycemia. Iji gbochie nke a, ịhọrọ nlezianya nke usoro na nri maka okwu ọ bụla dị mkpa. N'oge ọgwụgwọ, ekwesịrị ilebara anya pụrụ iche mgbe ị na-anya ụgbọ ala na ọrụ chọrọ nnukwu itinye uche na nlebara anya.

Usoro usoro onunu ogwu

A na-a oụ ọgwụ ahụ n’oge a na-eri nri ma ọ bụ ozugbo nri. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ogologo glucose ọbara.

Usoro izizi a na-abụkarị mbadamba 1-3 / ụbọchị yana nhọrọ nwayọ nwayọ nke ọgwụ ruo mgbe a ga-enweta ụgwọ nkwụghachi nke ọrịa ahụ. Oke kachasị kwa ụbọchị bụ mbadamba ise.

A na-a theụ ọgwụ ahụ ugboro abụọ / ụbọchị (ụtụtụ na mgbede).

Nsonaazụ

Mmetụta ndị na-achọghị ka enwere ike ịbịara gị mgbe ị na-ewere Glimecomb na-abụkarị n'ihi oke mmachi ya ma ọ bụ enweghị ike n'akụkụ ahụ onye ọrịa nwere ike ịdabere na ya. Ọdịnaya nke usoro sulfonylurea na-eme ka ohere dị ukwuu nke nsonaazụ ya dịkwuo egwu. Enweghi ike ịhọrọ onye ọrịa maka mmepe nke lactic acidosis, mịga na-eso ya, adịghị ike oge niile, oke ụra, yana ịbelata mgbu na mpaghara apịtị yana mbelata mgbali na akwara.

Ihe ndị a bụ mmetụta ndị a na-achọghị mgbe ị na-ewere Glimecomb:

• mmepe nke hypoglycemia na lactocidosis nwere ihe mgbu mgbu niile dị mkpa,
• ọdịdị nke afọ ọsịsa na flatulence,
• Uche ị na-enwe mgbe nile afọ,
• belata agụụ agụụ,
• oge uto nke uto ọbara n'ọnụ na akpịrị,
• mmepe nke ọrịa ọrịa imeju siri ike (ịba ọcha n'anya, wdg) dị ụkọ
• mmeghachi omume nfụkasị ahụ na mmiri mejupụtara (urticaria, itching, etuto ahụ,
• ọbara ọbara (ụdị rashes dị iche iche)
• enwere nsogbu nke enweghi ike ịhụ ụzọ mgbe ị na-ewere Glimecomb.

Ọ bụrụ na ịnwere mgbaama ndị a dị n'elu, ị kwesịrị ịkpọtụrụ onye ọkachamara ozugbo.

N'ime ndị ahịa ọgwụ Russia, ọnụahịa nke Glimecomb dị iche site na 200 ruo 600 rubles, dabere na nkwakọ ngwaahịa na ọnụ ọgụgụ mbadamba dị na ya, yana onye na-ebubata ya na mpaghara ire ya. Costgwọ ọgwụ a na-eme ka ọ bụrụ ọnụ ala maka ọnụ ọgụgụ buru ibu nke ndị bi, ya mere na ịchọrọ na ahịa ọgwụ. Ya mere, ọnụahịa dị elu na ụlọ ahịa n'ịntanetị maka mbadamba Glimecomb bụ 40 mg + 500 mg 450 rubles kwa ngwugwu, nke nwere mbadamba 60. N'ime ụlọ ahịa ọgwụ network, ọnụ ahịa ọgwụ maka mbadamba 60 ga-abụ ihe 500-550 rubles.

Ihe ana - eme glimecomb bu ogwu ndia:

• Gliformin (ihe dị ka 250 rubles maka mbadamba 60), ụkpụrụ nke ime ihe bụ nke Glimecomb, ihe mejupụtara bụ otu ihe, mana ọnụnọ insulin na-eme ka ọgwụ a ghara ịma mma,
• Diabefarm (maka mbadamba 60, ị ga-akwụ ụgwọ ihe dịka 150 rubles). O nwere ntinye uche siri ike nke glyclazide - 80 mg, nke choro ikpocha otu nsogbu dika Glimecomb.
• Gliclazide MV (nkezi ọnụahịa maka mbadamba 60 bụ 200 rubles). Ọ nwere ihe mejupụtara dị iche na Glimecomb, ọ nwere naanị 30 mg nke glycoslazide. Ngosipụta maka ojiji bụ otu ihe dị na ọgwụ mbụ.

Dodoụbiga ya ókè

N'ihe banyere njupụta nke Glimecomb, lactacidosis na hypoglycemia na-ewere ọnọdụ. Iji lụsoro ọnọdụ ndị a, a na-enyekarị ọgwụgwọ maka ịwa ahụ ụkwụ. Ọrịa glycemia dị mkpa iji glucose ma ọ bụ ihe ngwọta nke shuga n'ime (na ogo nwayọ nwayọ ma ọ bụ agafeghị oke). N'okwu ndị siri ike karị, ruo ọnwụ nke mmụọ, ekwesịrị inye nchịkwa glucose 50% (enwere ike dochie ya na glucagon). Ozugbo onye ọrịa nwetaghachiri onwe ya, ọ dị mkpa inye ya nri nwere nnukwu carbohydrate iji gbochie ọrịa hypoglycemia.

Ọzọkwa, ọ bụrụ na ị drugụ ọgwụ ọ drugụ drugụ na-enweghị nnukwu nsogbu, onye ọrịa ahụ nwere ike inwe ahụ iru ala n'ụdị akpịrị oge ruo nkụda mmụọ, ọgbụgbọ, flatulence na afọ ọsịsa, yana ịmeghari migraine. N'okwu a, ịkwesịrị itinye enyemaka mbụ ozugbo. N'ụlọ, ọ dị mkpa ịsacha afọ ma wepụ ọgwụ ahụ ozugbo na nri diges, na-esote nri nwere carbohydrates. Ọ bụrụ na ọ dị mkpa, ịga n'ụlọ ọgwụ na-esote omume ga-ekwe omume n'okpuru nlekọta oge niile nke ọkachamara.

Ofdị irè nke ọgwụ a karịa nchịkwa shuga ọbara na ọrịa shuga nke ụdị nke abụọ, yana ọnụ ala ya, na-eme ka ọgwụ ahụ bụrụ nke a ma ama ma nweta ọtụtụ nyocha dị mma. Mana echefula banyere nsonaazụ ndị ọgwụ a nyere. Ọ bụ n'ihi nnukwu ndepụta nke mmetụta na-adịghị mma ka achọpụtara nyocha na-adịghị mma nke ndị ọrịa. N'okpuru bụ ụfọdụ nyocha maka ọgwụ ndị a:

Dị ka usoro omume siri gosi, glimecomb bụ ọgwụ a ma ama na ọgwụgwọ ụdị ọria mamịrị 2. Nchikota ọnụahịa, ịdị mma na arụmọrụ dị elu na-eme ka mbadamba ihe mara mma na ahịa ọgwụ.

Mmetụta akụkụ

Site na usoro endocrine: hypoglycemia (nke megidere usoro dosing regimen na nri na-ezighi ezi) - isi ọwụwa, ịda mba, agụụ, mmụba ọsụsọ, ike ọgwụgwụ, palpitations, ọgbụgba, njiri nkwaghari nke mmeghari, nsogbu akwara ozi nwa oge, na ịba ụba nke hypoglycemia, ọnwụ nke njide onwe onye ga-ekwe omume, ọnwụ nke mmụọ.

Site n'akụkụ nke metabolism: n'ọnọdụ ụfọdụ - lactic acidosis (adịghị ike, myalgia, nsogbu nke akụkụ iku ume, iro ụra, mgbu afọ, hypothermia, ọbara mgbali, bradyarrhythmia).

Site na usoro digestive: dyspepsia (ọgbụgbọ, afọ ọsịsa, mmetụta nke oke na epigastrium, "ụtọ" n'ọnụ), belatara agụụ (ogo nke mmeghachi omume ndị a na-ebelata ọgwụ mgbe ị na-eri nri), ịba ọcha n'anya, cholestatic jaundice (iwere ọgwụ dị mkpa) , mmụba nke ọrụ nke hepatic transaminases, alkaline phosphatase.

Site na sistemu hemopoietic: adịkarịghị - mgbochi nke ụmị ọkpụkpụ (anaemia, thrombocytopenia, leukopenia).

Mmeghachi omume nfụkasị ahụ: itching, urticaria, flop na maculopapular.

Ndị ọzọ: enweghi ike ịhụ ụzọ.

Ọ bụrụ na nsonaazụ ndị ọzọ, a ga-belata dose ahụ ma ọ bụ kwụsị ọgwụ ahụ ruo nwa oge.

Nsonaazụ ndị ọzọ a na-ahụkarị na njikọta sulfonylurea: erythropenia, agranulocytosis, hemolytic anaemia, pancytopenia, vasculitis nfụkasị, ọrịa imeju na-egbu ndụ.