Nsonaazụ ojiji nke Amikacin 1000 mg na prostatitis

A na-eme ọgwụ ahụ n'ụdị ọcha ntụ ntụ, site na ya ọ dị mkpa iji dozie usoro maka nchịkwa intramuscular na intravenous.

Ihe na-arụ ọrụ bụ amikacin sulfate, nke n'ime karama 1 nwere ike ịbụ 1000 mg, 500 mg ma ọ bụ 250 mg. Ihe inyeaka nwekwara: mmiri, disodium edetate, hydrogen phosphate sodium.

Omume ọgwụ

Ogwu ogwu enerieen̄ ya ìre ogwu usun̄ ya. Ọgwụ nwere mmetụta antibacterial, na-ebibi ụdị nje ndị na-eguzogide cephalosporins, na-ebibi mkpụrụ ndụ cytoplasmic ha. Ọ bụrụ na edebere benzylpenicillin n'otu oge na inje, a ga-ahụ mmetụta mmekọrịta na ụfọdụ ụdị. Ọgwụ anaghị emetụta microorganisms anaerobic.

Mwepụta wepụtara ya na ihe mejupụtara

Ọgwụ dị n'ụdị ntụ ntụ, site na ya nke edoziworo maka intramuscular and intravenous injection. Ọ bụ ihe dị n’ime ude ude hygroscopic microcrystalline a na-eweta n’ime karama iko dị milimita iri. Vial ọ bụla nwere amikacin sulfate (1000 mg). A na-etinye karama 1 ma ọ bụ 5 na kaadiboodu nwere ntuziaka.

Mlọ ọgwụ

Mgbe agwara intramuscular, a na-etinye ọgwụ ahụ 100%. Penetrates banye n’akwara ndị ọzọ. Ihe ruru 10% jikọrọ protein protein. A na-ekpughere ntụgharị na ahụ. Ọ na-ewepụta ya site na akụrụ na-agbanweghi ihe dị ka awa 3. Amta ụbara amikacin na plasma ọbara dịkarịsịrị 1.5 awa mgbe ịgba ọgwụ ịgba. Mkpochapu ntaramahụhụ - 79-100 ml / min.

Ihe na-arụ ọrụ bụ amikacin sulfate, nke n'ime karama 1 nwere ike ịbụ 1000 mg, 500 mg ma ọ bụ 250 mg.
Amikacin nwere mmetụta antibacterial, na-ebibi ụdị nje ndị na-eguzogide cephalosporins, na-ebibi mkpụrụ ndụ cytoplasmic ha.
A na-eme ọgwụ ahụ n'ụdị ọcha ntụ ntụ, site na ya ọ dị mkpa iji dozie usoro maka nchịkwa intramuscular na intravenous.

Mlọ ọgwụ

Amikacin nwere mmetụta nje. Ihe na-arụ ọrụ na-emekọ ihe n'okpuru 30S nke ribosomes ma na-egbochi guzobe matriks na ebufe ogige RNA. Ọgwụ nje na-egbochi mmepụta protein protein na-eme cytoplasm nke mkpụrụ ndụ nje. Ọgwụ dị irè megide:

• gram-adịghị mma aerobic nje (pseudomonas, Escherichia, Klebsiella, serrations, Ndokwa, enterobacter, Salmonella, Shigella),
• Ọrịa nje dị mma (staphylococci, gụnyere ụdị na-eguzogide ọgwụ penicillin na cephalosporins 1st).

Mgbanwe mgbanwe dị iche iche maka amikacin nwere:

• streptococci, gụnyere ụdị ọbara haemolytic,
• fecal enterococcus (a ghaghi inye ọgwụ a yana ijikọ ya na benzylpenicillin).

Nsonaazụ nke ọgwụ nje anaghị emetụta nje nje anaerobic na nje nje intracellular. Egwuregwu ọgwụ ahụ anaghị emebi emebi site na enzymes nke na-ebelata ọrụ nke aminoglycosides ndị ọzọ.

Ihe ngosi maka iji Amikacin 1000 mg

Ihe ngosiputa maka ochichi nke ogwu bu:

• Ọrịa na-efe efe nke akụkụ okuku ume na (oyi baa, njọ nke bronchitis na-adịghị ala ala, purulent pleurisy, pulmonary abscess),
• ọrịa septisiia nke nje na-akpata amikacin,
• nje na-emebi akpa obi,
• ọrịa na-efe efe nke akwara ozi (meningitis, meningoencephalitis),
• ọrịa afọ (cholecystitis, peritonitis, pelvioperitonitis),
• ọrịa na-efe efe na ọnya afọ nke urinary tract (mbufụt nke akụrụ na ọnya, ọnya nje nke urera),
• ọnya ọnya anụ ahụ dị nro (ọnya na-efe efe, ihe nrịba nke nje na nke herpetic na-efe efe, ọnya trophic dị iche iche sitere, pyoderma, phlegmon),
• Usoro mbufụt ke akụkụ pelvic (prostatitis, cervicitis, endometritis),
• ọnya nke na - efe efe nke anụ ahụ na akwara nke na - arịa ọrịa ogbu na nkwonkwo, osteomyelitis),
• nsogbu ndị metụtara postologi na-esonye na ntopute nke nje bacteria.

Ngwaahịa egosipụtara

Ozi Ngwaahịa

• Usoro onunu ogwu: 1000 mg
• Mpempe nnabata: uzuzu maka nkwadebe nke ihe n ’d / n’ime / na nke m / nnabata nke ihe eji arụ ọrụ: ->
• Mbukota: fl.
• Emeputa: Synthesis OJSC
• Osisi na-emepụta: Synthesis (Russia)
• Ihe eji eme ihe: amikacin

Ntụ ntụ maka nkwadebe nke ihe ngwọta maka nchịkwa mgbochi intramuscular - 1 vial:

Ihe na-arụ ọrụ: Amikacin (n'ụdị sulfate) 1 g.

Kalama nke milimita 1000, mpempe mpempe akwụkwọ.

Ngwakọta ntụ ntụ maka nkwadebe nke ihe ngwọta maka nchịkwa ọbara na nke intramuscular nke ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ụcha ọcha bụ hygroscopic.

Mgbe nchịkwa m gachara, a na-etinye ya ngwa ngwa na kpamkpam. Cmax na plasma ọbara na nchịkwa m / m n'ọtụtụ nke 7.5 mg / n'arọ - 21 μg / ml, mgbe minit 30 nke iv infusion na dose nke 7.5 mg / kg - 38 μg / ml. Mgbe ogwesiri intramuscular nke Tmax - ihe dị ka awa 1.5

A na-agbado oge ịta ahụ dị omimi na iv ma ọ bụ nchịkwa intramuscular maka awa 10-12.

Indmịnye protein ndị dị na plasma bụ 4-11%. Vd n'ime ndị okenye - 0.26 l / n'arọ, na ụmụaka - 0.2-0.4 l / n'arọ, n'ime ụmụ amụrụ ọhụrụ: na nwata erughị 1 izu wee tụta ihe na-erughị 1500 g - ruo 0.68 l / n'arọ, na afọ erughị 1 izu ma tụọ ihe karịrị 1500 g - ruo 0,58 l / n'arọ, n'ime ndị ọrịa nwere ọnya cystic - 0.3-0.39 l / n'arọ.

A na-ekesa ya nke ọma na mmiri extracellular (ọdịnaya nke etuto, ihe na -akasị anụ ahụ, ascitic, pericardial, synovial, lymphatic and peritoneal fluid), a na-ahụ ya anya na oke mmamịrị, dị ala - na bile, mmiri ara ara, ihu ọchị nke anya, ihe gbasara akwara ozi, sputum na eriri azụ mmiri. Ọ na-abanye nke ọma na akwara niile nke ahụ ebe ọ na-agbakọta intracellularly, a na-ahụ ihe ndị dị elu na akụkụ ahụ nwere ọbara dị mma: akpa ume, umeji, myocardium, na akụrụ, na akụrụ, ebe ọ na-agbakọta na ngwongwo cortical, mkpụkọ dị ala - na akwara, anụ ahụ adipose na ọkpụkpụ .

Mgbe etinyere ya na usoro ọgwụgwọ oke (nke kwesịrị) maka ndị okenye, amikacin anaghị abanye na BBB, ya na mbufụt nke meninges, permeability na-abawanye ntakịrị. N'ime ụmụ amụrụ ọhụrụ, a na-enwetakarị ohere dị elu na mmiri sel akpa nwa ga - eme nke ọma karịa na ndị okenye. Penetrates site na ihe mgbochi placental: achọtara n’ọbara nke nwa ebu n’afọ na mmiri ọmụmụ.

T1 / 2 n'ime ndị okenye - awa nke 2-4, na ụmụ amụrụ ọhụrụ - 5-8 awa, na ụmụaka toro eto - awa 2.5-4. T1 / 2 nke ikpeazụ - karịa awa 100 (eweputara na depot intracellular).

Ọ bụ ya mere akụrụ site na nzacha ụwa (65-94%), ọkachasị adịghị agbanwe agbanwe. Mkpochapu ntaramahụhụ - 79-100 ml / min.

Pharmacokinetics n'ihe gbasara ọrịa.

T1 / 2 n'ime ndị okenye nwere ọrụ akụrụ na-arụ ọrụ dịgasị iche dabere na ogo nke nkwarụ - ruo 100 awa, n'ime ndị ọrịa nwere cystic fibrosis - awa 1-2, na ndị ọrịa nwere ọnya na ọbara mgbali elu, T1 / 2 nwere ike ịdị mkpụmkpụ karịa nkezi n'ihi mmụba dị elu n'ihi mmụba dị elu. .

A na-ewepụ ya n'oge ịba ọcha n'anya (50% na awa 4-6), usoro nyocha nke na - adịchaghị mma (25% na awa 48-72).

Ọgwụ nje nke na-emepụta ihe dị ka mkpụrụ nke aminoglycosides, na-egbu nje. Site na itinye 30S nke ribosomes nke 30S, ọ na-egbochi ịmepụta njem nke ụgbọ njem na onye ozi RNA, na-egbochi mkpokọ protein, ma na-ebibakwa membranes cytoplasmic nke nje.

Arụ ọrụ nke ukwuu megide microorganisms nke aerobic gram-Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Somefọdụ micromgangan gram-positive: Staphylococcus (gụnyere iguzogide penisilini, ụfọdụ cephalosporins). Anaghị arụ ọrụ ngwa ngwa megide Streptococcus spp.

Site na nchịkwa nke oge a na benzylpenicillin, ọ na-egosipụta mmetụta synergistic megide ụdị mmiri Enterococcus faecalis. Microorganisms anaerobic na-eguzogide ọgwụ. Amikacin anaghị arụ ọrụ n'okpuru ọrụ nke enzymes na-eme ka aminoglycosides ndị ọzọ na-arụ ọrụ, ma nwee ike ịnọgide na-arụ ọrụ megide ụdị Pseudomonas aeruginosa na-eguzogide tobramycin, gentamicin na netilmicin.

Ọgwụ nje nke aminoglycoside otu.

A na-eji amamacin abanye / na amikacin maka nkeji 30-60, ọ bụrụ na ọ dị mkpa, site na jet.

Ọ bụrụ na arụrụ ọrụ ezumike ezumike ezumike, mbelata dose ma ọ bụ mmụba n'etiti oge dị n'etiti ọchịchị ndị dị mkpa. N'ihe banyere mmụba na etiti oge nke nchịkwa (ọ bụrụ na amabeghi na uru QC adịghị, na ọnọdụ onye ọrịa kwụsie ike), etinyere nkeji oge n'etiti nchịkwa ọgwụ site n'ụkpụrụ a:

Maka nchịkwa iv (drip), ọgwụ na-ebu ụzọ jiri 200 ml nke 5% dextrose (glucose) edozi ma ọ bụ 0.9% sodium chloride solution. Ntinye uche nke amikacin na mmezi maka ochichi iv ekwesịghị gafere 5 mg / ml.

Agbata oge (h) = nlebara anya n'ọbara × 9.

Ọ bụrụ na itinye uche nke serum creatinine bụ 2 mg / dl, mgbe ahụ a ga-enyerịrị otu mkpụrụ ọgwụ a tụrụ aro (7.5 mg / n'arọ) kwa awa 18. Site na mmụba na nkeji oge, a naghị agbanwe otu mmiri.

N'ihe banyere mbelata nke otu mkpụrụ ọgwụ yana usoro usoro ị doụ mmiri oge niile, usoro izizi maka ndị ọrịa nwere ọdịda akwara bụ 7.5 mg / kg. Ngụkọta nke usoro onodu ogwu a na -eme dị ka usoro a si dị:

Subsequhe na-esote (mg), a na-elekọta kwa awa iri abụọ na abụọ = KK (ml / min) na onye ọrịa × ọgwụ mbụ (mg) / KK bụ ihe dị mma (ml / min).

• Ọrịa akụkụ akụkụ iku ume (ọnya afọ, oyi baa, nsogbu nke akpa ume, akpa ume),
• sepsis
• oria endocarditis,
• Ọrịa CNS (gụnyere meningitis),
• ofufe ọrịa nke eriri afọ (gụnyere peritonitis),
• ọrịa urinary na-efe efe (pyelonephritis, cystitis, urethritis),
• ọnya na-efe efe nke anụ ahụ na anụ ahụ dị nro (gụnyere ọnya na-ere ọkụ, ọnya na ọrịa mgbali dị iche iche),
• ọrịa biliary tract
• ọrịa nke ọkpụkpụ na nkwonkwo (gụnyere osteomyelitis),
• ọnya ọrịa
• ọrịa na-efe efe postolowo.

• Auditory akwara neuritis,
• nnukwu nsogbu gbasara akụrụ na azụ azotemia na uremia,
• ime
• hypersensitivity nke mmiri ọgwụ,
• hypersensitivity na aminoglycosides ndị ọzọ na akụkọ ihe mere eme.

Na ịkpachapụ anya, ekwesịrị iji ọgwụ ahụ mee ihe maka myasthenia gravis, parkinsonism, botulism (aminoglycosides nwere ike ibute mgbasa nke neuromuscular, nke na-eduga n'iwekwu akwara ọkpụkpụ), akpịrị ịkpọ nkụ, ọdịda akụrụngwa, na oge ọmụmụ, na ụmụ aka na-amụghị amụ, na ndị agadi agadi, na oge lactation.

Contraindicated na ime na ụmụaka n'okpuru 6 afọ.

Site na usoro digestive: ọgbụgbọ, ọgbụgbọ, ọrụ imeju na-arụ ọrụ (ụba ọrụ nke ọrịa hepatic transaminases, hyperbilirubinemia).

Site na sistemụ hemopoietic: anaemia, leukopenia, granulocytopenia, thrombocytopenia.

Site n'akụkụ nke sistemụ akwara na akụkụ akwara: isi ọwụwa, iro ụra, mmetụta neurotoxic (ntugbu akwara, ọnya na-eme mkpọtụ, ọnya na-egbu egbu), nfe na-emegharị neuromuscular (njide akụkụ iku ume).

Site na akwara anụ ahụ: ototoxicity (ọnwụ ịnụ, vestibular na nsogbu labyrinth, ntị chiri agbagha), nsonaazụ na-emetụta ngwa ọrụ vestibular (ịchọpụta mmegharị, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ).

Site na usoro urinary: nephrotoxicity - arụ ọrụ ezughị ezu ọrụ (oliguria, proteinuria, microredituria).

Mmeghachi omume nfụkasị: ọnya ọnya, itching, akpọnwụ akpịrị, ahụ ọkụ, ọnya Quincke.

Mmeghachi omume mpaghara: ihe mgbu na saịtị ịgba ahụ, dermatitis, phlebitis na periphlebitis (ya na nchịkwa iv).

Ọ bụ nke ọgwụ ekwekọghị na penisiliniins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, vitamin B na C, na chloride potassium.

Oke kachasị maka ndị okenye bụ 15 mg / kg / ụbọchị, mana ọ karịghị 1.5 g / ụbọchị maka ụbọchị 10. Ogologo oge ọgwụgwọ ya na a / na ntinye bụ ụbọchị 3-7, yana ụbọchị / m - 7-10.

Maka ụmụ amụrụ ọhụrụ, otu ụzọ izizi bụ 10 mg / kg, mgbe ahụ 7.5 mg / n'arọ kwa awa 18-24, maka ụmụ amụrụ ọhụrụ na ụmụaka na-erubeghị afọ 6, ọgwụ mbụ bụ 10 mg / kg, mgbe ahụ 7.5 mg / kg ọ bụla 12 h maka ụbọchị 7-10.

Maka apa ọkụ a na - ebute oria, a ga - achọ ọgwụ nke 5-7.5 mg / kg kwa elekere 4-6 n'ime ọ bụla n'ihi mkpụmkpụ T1 / 2 (awa 1-1.5) na ndị ọrịa a.

Mmeghachi nke nsí - ịnụ ụfụ, ataxia, dizzness, nsogbu nke urination, akpịrị ịkpọ nkụ, agụụ, agụụ, ọgbụgbọ, mkpọtụ ma ọ bụ inwe afọ nri na ntị, ọdịda nke iku ume.

Etu esi ewere Amikacin-1000

Ọgwụ a na-abanye n'ime ahụ yana enyemaka nke injections. Shouldkwesịrị ịkpọ dọkịta gị ka ịhọrọ usoro ọgwụgwọ kwesịrị ekwesị ma ọ bụ gụọ ntuziaka maka ọgwụ.

Tupu ịmalite iji ya, a ga-eme nnwale nke ọgụgụ isi. Maka nke a, a na-enye ọgwụ nje n'okpuru anụahụ.

Maka umuaka kariri otu onwa na ndi okenye, nhọrọ onunu ogwu 2 ga - ekwe omume: 5 mg kwa 1 n'arọ nke ibu mmadu ugboro ato n ’ụbọchị ma obu 7.5 mg kwa 1 kg nke ịdị arọ mmadụ ugboro 2 n’ụbọchị. Usoro ọgwụgwọ ya dị ụbọchị iri. Oke kachasị kwa ụbọchị bụ 15 mg.

Amachibidoro iji ọgwụ eme ihe na usoro mkpali na akwara auditory.
Amacacin na emebi akụrụ.
Shouldkwesịrị ịkpọ dọkịta gị ka ịhọrọ usoro ọgwụgwọ kwesịrị ekwesị.
Ọgwụ a na-abanye n'ime ahụ yana enyemaka nke injections.
Tupu ị theụ ọgwụ ahụ, ọ dị mkpa iji nyocha nyocha nke ọgụgụ isi, n'ihi na a na-enye ọgwụ nje n'okpuru anụahụ.
Usoro ọgwụgwọ ya na Amikacin na-anọ ụbọchị iri.

Maka ụmụ amụrụ ọhụrụ, usoro ọgwụgwọ ga-adị iche. Nke mbu, a na enye ha ogwu 10 kwa ubochi, mgbe emesiri ka onodu ogwu belata 7.5 mg kwa ubochi. Na-emeso ụmụ ọhụrụ ihe karịrị ụbọchị iri.

Nsonaazụ nke usoro ọgwụgwọ na ọgwụgwọ na-egosi n'ụbọchị mbụ ma ọ bụ n'ụbọchị nke abụọ.

Ọ bụrụ na mgbe ụbọchị 3-5 ọgwụ ahụ arụghị ọrụ dị ka achọrọ, ị kwesịrị ịkpọtụrụ dọkịta ka ịhọrọ ọgwụ ọzọ.

Ọkpụkpụ afọ

Mmadu nwere ike iru ura, ọgbụgbọ, hyperbilirubinemia.

Ekwesịrị ịkpachara anya mgbe ị na-a theụ ọgwụ ahụ na agadi.
A na-egosipụta mmeghachi omume nfụkasị nke ọgwụ ahụ site na ncha ntutu, itching.
A naghị atụ aro ka ịkwọ ụgbọala ahụ ma ọ bụrụ na rịbaara nsonaazụ ndị ọzọ: nke a nwere ike ibute onye ọkwọ ụgbọ ala na ndị ọzọ ihe egwu.

Ntụziaka pụrụ iche

Popufọdụ ndị bi kwesịrị ịgbaso iwu pụrụ iche maka ị .ụ ọgwụ.

Enwere ike itinye ọgwụ maka ụmụaka ma ọ bụrụ na uru ọgwụgwọ ahụ karịrị mmerụ ahụ ọ bụla.
Edere ọgwụ a ka ọ bụrụ naanị ụmụ nwanyị dị ime na ọnọdụ ndị ahụ mgbe ndụ nwanyị dabere na ị theụ ọgwụ.
Amachibidoro ọgwụ a n'oge a na-enye ya ara.

Mmekọrịta na ọgwụ ndị ọzọ

Iji otu oge eji ọgwụ ndị ọzọ, ọ ga-ekwe omume mmeghachi omume na-adịghị mma. A na-atụ aro iji ihe ịchọ mma, ihe ngwọta maka lenses kọntaktị na-akpachara anya n'oge ọgwụgwọ.

N'oge ị ofụ ọgwụ ahụ, a na-atụ aro iji ihe ịchọ mma na-akpachara anya.
An overụbiga ọgwụ ókè, akpịrị na-akpọ onye ọrịa nkụ.Ọ bụrụ n ’ị ofụ ọgwụ ọgwụ gabigara, a ga-akpọrịrị ụgbọ ihe mberede.

Mgwakọta chọrọ ịkpachara anya

Site na cyclosporine, methoxyflurane, cephalotin, vancomycin, NSAID, na-eji nlezianya eme ihe, ebe ọ bụ na ohere nke ịmalite nsogbu nsogbu gbasara akụrụ na-abawanye. Na mgbakwunye, jiri nlezianya kpoo ya, cisplatin. Ihe ize ndụ nke nsogbu na-abawanye mgbe ị na-ewere ndị ọrịa na-agwọ ọrịa.

Mmanya ndakọrịta

Amachibidoro ị toụ mmanya na-aba n'anya n'oge ịgwọ ọrịa.

Analogs di ka ihe osisa. Ndị ọrụ dị irè bụ Ambiotik, Lorikacin, Flexelit.

Amachibidoro ị toụ mmanya na-aba n'anya n'oge ịgwọ ọrịa.
Ihe analog nke ọma bụ ọgwụ bụ Loricacin.
Ọ gaghị ekwe omume inweta ọgwụ ma ọ bụrụ na dọkịta edebeghị ya.

Amikacin 1000 Nyocha

Diana, 35 afọ, Kharkov: “Ọkachamara urologist nyere ọgwụ ka a gwọọ ọrịa cystitis.Ọ were otu oge ọgwụ ndị ọzọ, ọgwụgwọ ndị mmadụ. O nyeere aka ngwa ngwa, achọpụtara m ahụ efe site na ụbọchị mbụ. Ngwá ọrụ dị irè ma dị ọnụ ala. "

Dmitry, 37 dị afọ 37, Murmansk: “Ọ gwọtara ara mgbu nke Amikacin. Ọgwụ ngwa ngwa, nke dị irè na-enyere aka, ọbụlagodi na ọ bụ ihe na-enye obi ụtọ ịnye mmadụ ọgwụ ugboro abụọ n'ụbọchị. Afọ na ọnụ ala dị ala. "