Glycvidone (glurenorm) na glipizide (minidiab) n'ịgwọ ọrịa shuga

Glycidone na glipizide - ndị nnọchi anya ọgwụ ọgwụ na - wedata shuga sitere na otu sulfonylurea. Kedu ka glycidone ma ọ bụ glitizide si eme ihe na n'ọnọdụ dị a ?aa? Will ga-ahụ azịza ya n'isiokwu nke taa. Umunne m ndi enyi! Taa achoro m ikwusi okwu banyere ogwu nke otu ndi sulfonylurea, ma obughi banyere ogwu iwenyere shuga n’ozuzu, ebe obu na otutu ndi n’enweghi mmasi.

Ichetara, edegoro m akwụkwọ banyere ndị na - anọchite anya nnukwu otu ndị a n'isiokwu "Diabeton MV ma ọ bụ Gliclazide", "Glimepiride n'ịgwọ ụdị ọrịa shuga" 2, na n'ihe banyere maninil n'isiokwu "Ọgwụ ndị dị ala nke shuga na ndụ onye ọrịa nwere ọrịa shuga," ọ bụrụ n’agụghị nke ọ bụla, biko, arịọ m gị.

Glycvidone na glipizide abụghị ọgwụ ndị ama ama maka ịgwọ ọrịa shuga mellitus n'ozuzu. A na-ahụta ha dị ka ọgwụ ọgwụ nwere ike ịdalata shuga, ọ bụ ezie na usoro nke glycidone na glipizide yiri ndị ogbo ọzọ siri ike: mannil ma ọ bụ ọrịa shuga. Nke ahụ bụ, ha na - akpalite mkpụrụ ndụ beta nke na - eme pancreatic, na - eme ka mmiri ọgwụ insulin dịkwuo elu. A naghị edenye ọgwụ abụọ ahụ ka monotherapy, ọtụtụ oge dịka akụkụ nke ọgwụgwọ njikọta.

N'ezie, aha "glycidone", "glipizide" bụ ndị na-abụghị nke ala, na ụlọ ahịa ọgwụ ị nwere ike ịchọta ha n'okpuru aha azụmaahịa ndị ọzọ.

Glycvidone = Glenrenorm

A na-ahụkarị Glycvidone n'okpuru aha Glyurenorm, mana ị nwere ike ịchọta ọgwụ nwere aha ụwa. Nweta dị na mbadamba nkume na 30 mg. Usoro izizi bụ 1/2 mbadamba kwa ụbọchị, mgbe ahụ, usoro na / ma ọ bụ ugboro ole nchịkwa ga-abawanye. Oke kachasị glurenorm bụ mbadamba 4 kwa ụbọchị (120 mg / ụbọchị). A na-ewere ọgwụ ahụ nkeji iri atọ tupu nri, na-enye ya ohere ịnabata ma gbasaa mmetụta ya. Ọnụ ọgụgụ kachasị elu nke ihe a na-eme na oge kachasị elu nke ntinye nri - mgbe awa 1.5-2 gasịrị, oge ihe a na-eme bụ ihe dịka awa 8-10.

Otu ihe pụrụ iche nke glycidone bụ na ọ fọrọ obere ka ọ bụrụ na imeju ya na imeju ma na-ewepu ya na eriri afọ. Site na akụrụ, naanị 5% nke ọgwụ a kpochapụrụ, nke na-eme ka ndị ọrịa nwere akụrụ ghara iji ya mee ihe n’atụghị ụjọ.

Ebe ọgwụ a nwere mmetụta na-esighi ike, enwere ike iji ya na mbido ọrịa shuga mellitus maka ndị ọrịa na-enweghị oke ibu, mgbe ọkwa glucose ọbara adịghị elu. Ọ bụrụ na glurenorm adịghị arụ ọrụ, ọgwụ ọzọ sitere na otu a ka a na-edebere ya, ma ọ bụ ọgwụ ọzọ dochie ya.

Dị ka ọgwụ niile na -ebelata shuga, glycidone nwere otu ọgwụ mgbochi:

ụdị shuga 1
ime
lactation
ketoacidosis ma ọ bụ ketoacidotic coma

hypoglycemia (glucose ọbara dị ala)
ọgbụgbọ ọgbụgba
agụụ
mmeghachi omume nfụkasị ahụ
leukopenia
isi ọwụwa

Glipizide = minidiab

You nwere ike ịchọta glitizide na ụlọ ahịa ọgwụ n'okpuru aha "minidiab" ma ọ bụ "glibenesis." Mbadamba onwe ya pụrụ iche. Nke a bụ mbadamba ụrọ nke nwere ihe nchịkwa na - achịkwa, i.e., ihe na - arụ ọrụ, glibenesis, na - eji nwayọ wepụta, na - agafe ogologo eriri afọ, si otú a na-enye mbelata nke ọbara shuga na mmetụta dị ogologo. A na-ahụ mmetụta yiri ya na ọrịa mellitus.

Glipizide dị na mbadamba 5 mg. Ọ na-amalite ịrụ ọrụ mgbe nkeji iri na ise ruo 15-30, yabụ, ọ dị mkpa ị were ya nkeji iri na ise ruo iri atọ tupu iri nri. Mmetụta kachasị bụ mgbe awa 1,5-2 gachara, nọ na ọbara ruo ihe ruru awa iri abụọ. Emere mmetụta ahụ ka elekere abụọ na-esote tupu i jiri mita glucose ọbara ọbara n’ụlọ.

Bido takingụọ 5 mg kwa ụbọchị, jiri nwayọọ nwayọọ na-abawanye dabere na ọkwa nke glycemia. Ọgwụ kachasị kwa ụbọchị bụ 40 mg. Enwere ike ekewa ubochi ubochi abuo na ato.

Contraindications na nsonaazụ ndị ọzọ yiri nke glycidone (glurenorm).

Dịka m kwurula, ọgwụ ndị a na-arụ ọrụ nke ọma na njikọta yana ọgwụ ndị ọzọ na-alụ ọzọ. Dịka ọmụmaatụ, ọ dị mma na metformin, usoro ọgwụgwọ nke dọkịta kpebiri, yana thiosalidinedione (actos, avandium) ma ọ bụ insulin.

Na mkpokọta, nke a bụ ihe m chọrọ ikwu banyere glycidone na glipizide. Site na iji ihe omuma a, ị nwere ike ịtụle arụmọrụ nke ọgwụ ejiri, ma ọ bụrụ na ọ nweghị arụmọrụ, gbanwee ya ka ọgwụ siri ike. Iji mee ihe n'eziokwu, ọ na-esiri m ike ị drugsụ ọgwụ ndị a.

Ma na mpaghara dị iche iche na nnweta dị iche iche, ọ ga - ekwe omume na mgbakwunye na ha ị nweghị ihe ọzọ ịhọpụta dọkịta. Ọ na - eme ka ọgwụ a dabara gị nke ọma yana ọkwa suga dị n'ọbara, ịgaghị achọ ihe dị mma n'ihe ọma, mana were nwayọ were ọgwụ ndị a.

Site n'ụzọ, echefurula m ịhapụ njikọ na otu isiokwu na ọgwụ ọhụrụ maka ọrịa shuga maka ndị na-agụbeghị ma tụgharịa bụrụ nke mbụ na ntanetị. Isiokwu a bụ "Nkwa Nkwa na Usoro Ọrịa shuga."

Kedu ka akụkọ si amasị gị? Obi ga-atọ m ezigbo ụtọ ma ọ bụrụ na ị na-eso ndị enyi gị ekerịta ya site na ndị ọrụ mmekọrịta. netwọdi ka ndị nọ na mkpa, dị ka gị, na-enweta naanị ozi dị mkpa gbasara ọrịa shuga. Maka ịdị mma gị, n'okpuru edemede enwere bọtịnụ nke netwọ mmekọrịta mmadụ ama ama. netwok nke obodo igha itinye aha gi na mbu.

Site na ikpo ọkụ na nlekọta, ọkà mmụta endocrinologist Dilara Lebedeva

Omume ọgwụ

Glipizide - ihe nnọchianya hypoglycemic nke na-ekwu okwu, na-ezo aka n'ụkpụrụ nke sulfonylurea nke ọgbọ II. Na-akpali secretion nke insulin site na beta-endocrinocytes nke pancreas, na-abawanye ntọhapụ nke insulin.

Ọ na - eme ka insulin mara ihe. Ọ nwere hypolipPs, fibrinolytic Njirimara, na-egbochi nchịkọta platelet. Omume ahụ malitere nkeji 10-30 ka ị takingụ ọgwụ ahụ.

2dị shuga abụọ nke ọrịa mellitus (na enweghị usoro ọgwụgwọ nri).

Ngwa

A na-etinye dose ahụ n'otu n'otu dabere na foto nyocha nke ọrịa ahụ. Usoro izizi ụbọchị kwa ụbọchị bụ 2.5-5 mg. Ihe kacha otu bụ 15 mg. Oke kachasị kwa ụbọchị bụ 45 mg. Oge nchịkwa bụ 2-4 r / ụbọchị 30 nkeji tupu nri.

Mgbe ị na-edepụta glipizide mgbe ojiji insulin ma ọ bụ ihe ndị ọzọ hypoglycemic, a ga-atụle ngwa ngwa oriri nke glipizide n'ime ọbara na ekwesịrị ịchịkwa dose ahụ dabere na ọkwa nke glycemia 2-4 r / ụbọchị na ụbọchị 4-5 mbụ. Site na mmepe nke hypoglycemia, ọ bụrụ na onye ọrịa maara, a na-edenye glucose (ma ọ bụ ihe ngwọta shuga) n'ime.

Ọ bụrụ na mmụọ amaghị, a na-edozi glucose intravenous ma ọ bụ glucagon sc, intramuscularly ma ọ bụ intraven. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere carbohydrates iji zere ịmaliteghachi hypoglycemia. Site na mmerụ ahụ, ọnya na-efe efe, nnukwu ịwa ahụ, a ga-ebufere onye ọrịa ahụ ka ọ jiri insulin.

Mmetụta akụkụ

- Ikebịghike - hypoglycemia (ọkachasị na ndị agadi, ndị ọrịa na-esighi ike, na-eri nri oge adịghị mma, ị alcoholụ mmanya, na-arụ ọrụ imeju na akụrụ), ọnyụnyụ dyspeptik, isi ọwụwa, nke na-apụ na mmezi ọ̀gaghị.

- Akpukpo AR akpukpo ahu adighi eme, enwee udiri aru, achoghi iwepu ogwu.
- Ọ bụ oké obere - hematopoiesis.

Ihe omuma banyere ihe

Akụkụ a bụ hypoglycemic synthetic guarantee.

Enweghị ike ịgbanye Glipizide na mmiri ma ọ bụ mmanya na-egbu egbu, agbanyeghị, azịza NaOH (mkpokọta 0.1 mol / L) na mbelata nke disethylformamide. A na-emepụta ihe a na mbadamba ụrọ na mbadamba ihe ọ bụla

Ozugbo otu ihe batara n’ahụ onye ọrịa mamịrị, ọ na - eme ka mwepụta nke insulin ghara ịrụ ọrụ n’ime mkpụrụ nke beta nke islet ngwa ọrụ.

Glipizide na-eme dị ka ndị a:

Na -ebe glucose na glycosylated haemoglobin n’elu afọ efu.
Na - eme ka nnabata glucose na - abawanye ntakịrị - nhichapụ nke mmiri mmiri n'efu.
Na-ebelata ohere nke hyperglycemia mgbe ị risịrị nri.

Ihe eji arụ ọrụ adịghị emetụta metabolism lipid. Mgbado ya na-amalite mgbe nkeji iri atọ ji abanye ma ọ na-aga n'ihu ụbọchị dum. A na-ahụta mkpụmkpụ nke ihe ahụ mgbe ejiri awa 1-3 gachaa.

Okwesiri iburu n'uche na Glipizide ka nma adighi eji ya mgbe nri, ebe nnabata ya kpamkpam na-ebelata. Biotransformation nke ihe ahụ na-eme na imeju.

Akụkụ ahụ dị ka metabolite yana feces na mmamịrị, gụnyere na - agbanweghi agbanwe - ihe dịka 10%.

Ntụziaka maka ojiji

Tupu iji nkwadebe nwere glitizide, ịkwesịrị ịgakwuru dọkịta ma ọ bụ endocrinologist. Naanị dọkịta nwere ike iji nlezianya nyochaa izi ezi nke iji otu ngwaọrụ.

Mgbe ịzụrụ ọgwụ ahụ, ịkwesịrị iji nlezianya gụọ mpempe akwụkwọ ntụziaka. Usoro izizi bụ 5 mg, nke a na-ahụ maka otu ugboro n'ụbọchị tupu ma ọ bụ mgbe nri ahụ gasịrị. Ka oge na-aga, enwere ọdịmma ọrịa shuga nkịtị, enwere ike ịbawanye ọgwụ ahụ ruo 15 mg, na-ekewa nchịkwa nke ọgwụ ahụ ọtụtụ oge.

Ntụziaka ahụ na-ekwu na ọ bụrụ na azaghị ọgwụ ahụ, mana awa ole na ole agaala kemgbe ọgwụ dị mkpa, a ga-enye ọgwụ ngwa ngwa. Ma ọ bụrụ na ọ dịkarịa ụbọchị, ị ga-agbaso usoro ọgwụgwọ ọ na-emebu.

Ndị ọrịa nke ịka nká ma na-ata ahụhụ site na ọrịa imeju kwesịrị iji ọgwụ mee ihe na ntakịrị usoro - 2.5 mg kwa ụbọchị, na mbadamba oge ịhapụ oge - site na 5 ruo 10 mg otu ugboro, ọkacha mma n'ụtụtụ.

Dika ogwu ogwu ndi ozo, ekwesiri ịchekwa Glipizide n’ebe umuaka no ebe anakpo ya iru mmiri.

Ntuchi ogwu na ihe ojoo

Categoriesfọdụ ụdị ndị ọrịa mamịrị enweghị ike ị nweta ọgwụgwọ a.

Ntụziaka ndị ejikọtara na contraindications metụtara mmetụta nke mmadụ na ihe ahụ, akpịrị shuga, ụdị shuga, shuga, ketoacidosis, ịwa ahụ n'oge na-adịbeghị anya, afọ ime na oge inye ara.

N'okwu ikpe kachasị njọ, iji Glipizide mee omume n'oge ịmụrụ nwa. Mana ọ ghaghi ịkagbu iji ya ọnwa 1 tupu amụọ nwa.

N'ime oge ara, ị theụ ọgwụ ahụ ka amachibidoro.

Achọrọ ndụmọdụ dọkịta tupu iji Glipizide mee ihe, ebe ọ bụ na nchịkwa na-adịghị mma nke ọgwụ ahụ nwere ike ibute ọtụtụ nsonaazụ na-achọghị.

isi ọwụwa, nsụhọ ọgbụgba, ike ọgwụgwụ, ọbara ọgbụgba azụ, akpịrị ịkpọ nkụ, nkụda mmụọ, paresthesia, nchekasị, anya mgbu na ọnụnọ ọnụnọ,
flatulence, ọgbụgbọ, ọgbụgbọ, ọgbụgba ọbara na feces, afọ ntachi, dyspepsia na anorexia,
itching, rashes na hives,
pharyngitis, rhinitis na dyspnea,
jikọtara ya na sistem obi yana akpụpụta ọbara: arrhythmia, syncope, mmetụta nke ọkụ ọkụ na oke ọbara,
na - glycemia na ụdị ọrịa shuga abụọ nke ọrịa shuga na glycemic coma.
metụtara sistemụ ịkpụkọ anụ ahụ: belata agụụ mmekọahụ na dysuria.

Na mgbakwunye, ụfọdụ mmetụta ndị ọzọ nwere ike ịdapụta - nkwarụ, akpịrị ịkpọ nkụ, myalgia, arthralgia, sweating, mgbu anụ ahụ.

Efu, nyocha na analogues

Ebe ọ bụ na glipizide bụ akụkụ dị ike, enwere ike ịchọta ọtụtụ ọgwụ nwere ihe dị otú ahụ na ahịa ọgwụ Russia. Dịka ọmụmaatụ, Glucotrol CL na Glibenez Retard. Dabere n'ụdị ntọhapụ, ọnụahịa ọgwụ Glucotrol CL sitere na 280 ruo 360 rubles, na Glibenez Retard - site na 80 ruo 300 rubles.

Nyocha nke ọtụtụ ndị ọrịa mamịrị lụrụ ụdị ọgwụgwọ a bụ afọ ojuju. Agbanyeghị, ọtụtụ ndị chọpụtara na ọgwụgwọ ọgwụgwọ nke glipizide na-ebelata ka oge na-aga, yabụ a na-ejikarị ya na ọgwụ ndị ọzọ na-arịa ọrịa shuga. Otu n'ime uru ọgwụ dị nwere ike ịpụta ọdịiche dị mfe iji yana ọnụ ahịa na-eguzosi ike n'ihe nke ọgwụ nwere glitizide.

N'okwu ahụ mgbe otu ọgwụ adịghị mma n'ihi contraindications ma ọ bụ mmeghachi omume na-adịghị mma, dọkịta depụtara analog. Ọgwụ ndị a gụnyere:

Enweghị nkwenye nke dọkịta, ọgwụ ịchọrọ onwe ya adịghị mma. Nkwadebe nke nwere glitizide nwere ike inwe mmetụta ọjọọ n'ahụ ahụ mmadụ. Site n'iji ọgwụ n'ụzọ ziri ezi, ị nwere ike mee ka ọkwa shuga dị ka ọ dị mma ma wepụsịa ihe mgbaàmà nke ọrịa shuga. Mana anyị agaghị echezọ gbasara ọgwụgwọ mmega ahụ maka ọrịa shuga na ezigbo nri.

Na vidiyo dị n'isiokwu a, dọkịta ga-ekwu maka ọgwụ maka ọrịa shuga.

Ọgwụ Farmacology

Na-akpali mwepụta nke insulin site na mkpụrụ ndụ beta nke na-arụ ọrụ. Ọ na -ebelata ọkwa nke haemoglobin glycosylated na ịba ụba glucose na ndị ọrịa nwere ụdị ọrịa mellitus na-abụghị insulin na-agbadata. Na-ebelata hyperglycemia mgbe nri-nri gasịrị, na-eme ka ịnagide glucose na nhichapụ mmịpụta nke mmiri na-adịghị ala (na obere ntakịrị). Nzaghachi insulinotropic na-amalite n'ime minit 30 mgbe nchịkwa ọnụ gasịrị, oge iji mee ihe otu obere ruru awa 24. Ọ dịghị emetụta profaịlụ nke plasma ọbara.

N'ime nnwale na oke na ụmụ oke na nha 75 ugboro dị elu karịa MPD, ọ naghị ebute ọrịa carcinogenesis ma ghara emetụta ọmụmụ (oke). Emere nnyocha banyere nje nje, na na vivo , ekpugheghị Njirimara mutagenic.

Isdị ngwa ngwa na-abanye ngwa ngwa kpamkpam. Iri nri anaghị emetụta ngụkọta oge niile, mana ọ na-agbada ya ruo nkeji iri anọ. C_max kpebisiri ike awa 1 1-3 mgbe ọ gbasasịrị otu ọgwụ. Ndi_1/2 bụ awa 2–4. Mgbe ọ gbasịrị nwayọ nwayọ, ọ na-apụta n’ọbara mgbe awa 2-3 gachara, C_max Ọ na-eru mgbe awa 6-12. Ọ na-ejikọ protein ndị dị na plasma ọbara site na 98-99%. Olu nke nkesa mgbe nchịkwa iv bụ 11 L, nkezi T_1/2 - Oge awa 2-5. Nchikota Cl mgbe agwara otu ivish bụ 3 l / h. Biotrans gbanwee na imeju (ya na amaokwu nke mbụ - ntakịrị). Ihe na-erughi 10% na-agbanwegharị na mmamịrị na feces, ihe dị ka 90% dị n'ụdị metabolites na mmamịrị (80%) na feces (10%).

Mmetụta dị iche iche nke ihe Glipizide

Maka ụdị ngwa ngwa glitizide:

Site na ụjọ na akwara anụ ahụ: dizzness, isi ọwụwa, ehighi ura, ura, nchekasị, obi erughị ala, ọgba aghara, ọgba aghara, paresthesia, hypersthesia, veel n'ihu anya, mgbu anya, conjunctivitis, mbufụt azụ.

Site na sisitemu obi na obara (hematopoiesis, hemostasis): syncope, arrhythmia, ọbara ọgbụgba, akụrụngwa nke ọkụ dị ọkụ.

Site n'akụkụ nke metabolism: hypoglycemia.

Site na ngwara: anorexia, ọgbụgbọ, ọgbụgbọ, mmetụta nke ike dị na mpaghara epigastric, dyspepsia, afọ ntachi, ọbara ọgbụgba na stool.

Na akpukpo ahu: ọnya, urticaria, itching.

Site na usoro iku ume: rhinitis, pharyngitis, dyspnea.

Site na usoro mkpụrụ ndụ: dysuria, mbelata libido.

Ndị ọzọ: akpịrị ịkpọ nkụ, ịma jijiji, akụkụ ụkwara akwara, ihe mgbu na - abụghị mpaghara niile, arthralgia, myalgia, cramps, sweating.

Maka ụdị ngwa ngwa glitizide:

Site na ụjọ na akwara anụ ahụ: isi ọwụwa, nkụchi, iro ụra.

Site na sisitemu obi na obara (hematopoiesis, hemostasis): leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic ma ọ bụ aplastic anaemia.

Site n'akụkụ nke metabolism: ọrịa shuga insipidus, hyponatremia, ọrịa porphyrin.

Site na ngwara: ọgbụgbọ, ọgbụgbọ, mgbu epigastric, afọ ntachi, ịba ọcha n'anya nke ọrịa akpụkpọ (akpịrị na-acha odo odo nke akpịrị na ọnya akpọnwụ ọnya)

Na akpukpo ahu: erythema, maculopapular fash, urticaria, photoensitivity.

Ndị ọzọ: mmụba na mkpokọta nke LDH, alkaline phosphatase, bilirubin na-apụtaghị ìhè.

Mmekorita

Ralnweta mineral, glucocorticoids, amphetamines, anticonvulsants (ọgwụ hydantoin), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, ọgwụ mgbochi, epinephrine, ethacinic acid, giurimmeme, thymo gland, triamteren na ọgwụ ndị ọzọ na - ebute hyperglycemia. Anabolic steroid na androgens na-eme ka ọrụ hypoglycemic dịkwuo elu. Anticoagulants na-apụtaghị ìhè, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin na-eme ka mkpokọta nke irighiri irighiri ọbara dị n'ọbara (n'ihi nchụpụ pụọ na protein plasma) ma mee ngwa ngwa biotransformation. Ketonazole, miconazole, ngọngọ sulfinpyrazone na-abawanye ma bulie hypoglycemia. Na-emegide nzụlite mmanya, mmepe nke disulfiram-syndrome (afọ mgbu, ọgbụgbọ, ọgbụgbọ, isi ọwụwa) ga-ekwe omume. Ọgwụ Antithyroid na ọgwụ myelotoxic na-eme ka ohere nke ịmalite ịrịa agranulocytosis, nke ikpeazụ, na mgbakwunye - thrombocytopenia.

Dodoụbiga ya ókè

Ọgwụgwọ: mwepu ọgwụ, nnabata glucose na / ma ọ bụ mgbanwe nri n’ime ya na nlezianya nyocha nke glycemia, na nnukwu hypoglycemia (coma, ihe ọdịdọ) - ụlọ ọgwụ ozugbo, nchịkwa nke glucose ọgwụ dị 50% na ntanetị ọnụ (iv drip) nke 10% ngwọta glucose dị mkpa iji hụ na ịbara glucose ọbara karịa 5.5 mmol / l, nlekota glycemia dị mkpa ruo ụbọchị 1-2 mgbe onye ọrịa ahụ hapụsịrị. Dialysis adighi ike.