Glimecomb - ntuziaka maka ojiji, nyocha, analogues na ụdị mwepụta (mbadamba 40 mg 500 mg) nke ọgwụ maka ọgwụgwọ nke ụdị shuga na-enweghị insulin na ndị okenye, ụmụaka na ime ime.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Glimecomb. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara ojiji Glimecomb na-eme. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Glimecomb analogues na ọnụnọ nke ụdị analogues dị na nhazi. Jiri maka ọgwụgwọ nke ụdị shuga na-abụghị insulin na ndị okenye, ụmụaka, yana n’oge ime na lactation. Ngwakọta na mmekọrịta nke ọgwụ na mmanya.

Glimecomb - jikọtara ọgwụ hypoglycemic maka ojiji ọnụ. Glimecomb bụ ngwongwo abụọ nke ndị na-eme ọnụ hypoglycemic nke otu biguanide na otu kọmịkwa nke sulfonylurea. Ọ nwere palọ na extrapancreatic edinam.

Glyclazide (ihe mbụ na-arụ ọrụ nke ọgwụ Glimecomb) bụ usoro sitere na sulfonylurea. Na-akpali mmiri ọgwụ insulin site na pancreas, na-eme ka ahụrịị anụ ahụ na-emetụta insulin. Na-akpali ọrụ nke enzymes intracellular, gụnyere akwara glycogen synthetase. Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ, na - ebelata oge dị iche site na oge iri nri na mmalite insulin insulin, ma belata postprandial (mgbe ị risịrị) hyperglycemia. Na mgbakwunye na emetụta metabolism metabolism, ọ na - emetụta microcirculation, na - ebelata nrapado platelet na nchịkọta, na - egbu oge mmepe nke parietal thrombosis, na - egbochi vaskụla permeability ma na - egbochi mmepe microthrombosis na atherosclerosis, na - eweghachi usoro nke physiological parietal fibrinolysis, ma na - agbaghaghachi mmeghachi omume akwara. Na-eme ka mmepe nke ọrịa mamịrị na-arịa ọrịa retinopathy na-abụghị nke na-aba ụba, na-arịa nephropathy na-arịa ọrịa ogologo oge, a na-ahụta mbelata dị ukwuu na proteinuria. Ọ dịghị ebute mmụba n’arụ ahụ, ebe ọ nwere mmetụta kachasị na mbido insulin insulin ma ghara ibute hyperinsulinemia, ọ na - enyere aka belata oke ahụ n'ahụ ndị ọrịa buru ibu, na - agbaso nri kwesịrị ekwesị.

Metformin (ihe nke abụọ na-arụ ọrụ nke ọgwụ Glimecomb) bụ otu nke biguanides. Ọ na - eme ka nchịkọta glucose dị n'ọbara site na igbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na eriri afọ (GIT) ma na - abawanye ojiji nke anụ ahụ. Ọ na-ebelata mkpụkọ ọbara ọbara nke triglycerides, cholesterol na obere lipoproteins (LDL), kpebisiri ike na afọ efu, anaghị agbanwe ntinye uche nke lipoproteins nke njupụta dị iche. Ọ na - enyere aka ịgbatị ma ọ bụ belata ahụ. Na enweghị insulin n'ime ọbara, a naghị egosipụta mmetụta ọgwụgwọ. Ọkpụkpụ hypoglycemic anaghị akpata. Ọ na - eme ka akwara fibrinolytic dị n'ọbara n'ihi mkpesa nke onye na - egbochi nnabata profibrinolysin (plasminogen) ụdị anụ ahụ.

Ngwakọta

Glyclazide + Metformin + nke ndị bu ya.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, nnabata gliclazide dị elu. Ihe mgbochi protin Plasma bụ 85-97%. Metabolized na imeju. A na - abụkarị ya n'ụdị metabolites site na akụrụ ya - 70%, site na eriri afọ - 12%.

Mgbe nchịkwa ọnụ gachara, nnabata nke metformin bụ 48-52%. Anọrọ ngwa ngwa si na nri diges. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%. Mgbakwunye protein Plasma bụ nke ileghara anya. Metformin nwere ike ịgbakọta na mkpụrụ ndụ ọbara uhie. Ọ bụ ya bụ akụrụ, nke kachasị n’ụdị na - agbanweghi agbanwe (mmụba na tubular secretion) yana eriri afọ (ihe ruru 30%).

Ihe na-egosi

ụdị 2 ọrịa shuga mellitus (nke na-abụghị insulin) na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na ọgwụgwọ mbụ na metformin ma ọ bụ gliclazide,
dochie usoro ọgwụgwọ gara aga site na ọgwụ abụọ (metformin na gliclazide) na ndị ọrịa nwere ụdị shuga mellitus 2 (nke na-abụghị insulin) na ọkwa glucose ọbara dị mma.

Dị Mwepụta

Mbadamba 40 mg + 500 mg.

Ntuziaka maka usoro na usoro onunu ogwu

A na -ekwu Glimecomb ọnụ n'oge nri ma ọ bụ ozugbo nri. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ogologo glucose ọbara.

Usoro izizi na-abụkarị mbadamba 1-3 kwa ụbọchị yana nhọrọ nwayọ nwayọ nke ọgwụ ruo mgbe eburu ụgwọ kwụsịrị ọrịa ahụ. Oke kachasị kwa ụbọchị bụ mbadamba ise.

A na-a theụ ọgwụ ahụ ugboro abụọ n'ụbọchị (n'ụtụtụ na mgbede).

Mmetụta akụkụ

hypoglycemia (nke megidere usoro usoro onunu ogwu na nri ezughi oke) - isi ọwụwa, ike ọgwụgwụ, agụụ, ịsụsọ nke ukwuu, ike ọgwụgwụ, ahụ ike ọgwụgwụ, njiri mara mmeghari, nsogbu akwara ozi nwa oge,
na ịba ụba nke hypoglycemia, ọnwụ nke njide onwe onye, ọnwụ nke mmụọ
lactic acidosis - adịghị ike, myalgia, nsogbu nke akụkụ iku ume, iro ụra, mgbu nke afọ, hypothermia, mgbali ọbara (BP), bradyarrhythmia,
dyspepsia - ọgbụgbọ, afọ ọsịsa, mmetụta nke ịda mbà n'obi na epigastrium, ụtọ "ọla" n'ọnụ, ọnwụ nke nri,
ịba ọcha n'anya, cholestatic jaundice (ndọrọ ego choro ọgwụ),
mmụba nke ịba ọcha n'anya transpeases, alkaline phosphatase (ALP),
mgbochi nke ụmị ọkpụkpụ - anaemia, thrombocytopenia, leukopenia,
pruritus, urticaria, maculopapular rash,
mmebi anya
hemolytic anaemia,
nfụkasị vasculitis,
mẹ ndu-ishi ndu ojọgu.

Ihe ngbanwe

ụdị shuga mellitus (ọgwụ insulin)
ọrịa mamịrị ketoacidosis,
mamịrị precca, mamịrị shuga,
hypoglycemia,
oke nrụrụ akụrụ
ọnọdụ ọjọọ nke nwere ike iduga mgbanwe mgbanwe n'ọrụ akụrụ: akpịrị ịkpọ nkụ, ọrịa siri ike, ujo,
ajọ ọrịa ma ọ bụ nke na-adịghị ala ala nke gụnyere hypoxia anụ ahụ: nkụchi obi, iku ume iku ume, ụkwara ume ọkụ myocardial, ujo,
imeju imeju
porfria
tụụrụ ime
lactation (inye ara),
ojiji nke miconazole,
ọnọdụ chọrọ insulin ọgwụ, gụnyere ọrịa na-efe efe, nnukwu ịwa ahụ, mmerụ ahụ, oke ọkụ,
egbu egbu egbu,
nnukwu mmanya ịxụbiga mmanya ókè,
lactic acidosis (gụnyere akụkọ ihe mere eme)
jiri ma ọ dịkarịa ala awa 48 tupu na n'ime awa 48 mgbe ị mụsịrị redioisotope ma ọ bụ x-ray na ntinye nke ayodiin nwere ọdịiche,
na-agbaso nri kalori (obere kalori 1000 kwa ụbọchị),
hypersensitivity nke mmiri ọgwụ,
hypersensitivity na usoro ndị ọzọ dị na sulfonylurea.

Ime na lactation

Ihe ogwu Glimecomb di ime n’oge contraindicated. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n'ihe gbasara afọ ime n’oge ịlụ ọgwụ Glimecomb, ekwesịrị ịkagbu ya na ọgwụ insulin.

Glimecomb na - enye ndị ara ara, ebe ọ bụ na mmiri ara ehi nwere ike ịmị mmiri ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Jiri na umuaka

Jiri ndị ọrịa agadi

A naghị atụ aro ya iji ọgwụ Glimecomb mee ihe na ndị ọrịa gaferela afọ 60 ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke lactic acidosis.

Ntụziaka pụrụ iche

A na-eme ọgwụgwọ Glimecomb naanị na njikọta nri kalori, carb dị ala. Ọ dị mkpa ịdị na-enyocha ọkwa glucose mgbe niile n'ọbara na afọ na-enweghị nri na mgbe erichara nri, ọkachasị na ụbọchị mbụ ọgwụgwọ ọgwụ.

Enwere ike inye glimecomb naanị ndị ọrịa na-anata nri mgbe niile, nke na-agụnye nri ụtụtụ ma na-enye ezigbo carbohydrates.

Mgbe ị na-edepụta ọgwụ ahụ, ekwesịrị iburu n'uche na n'ihi nnweta nke ikike dị iche iche nke sulfonylurea, hypoglycemia nwere ike ịmalite, na n'ọnọdụ ụfọdụ n'ụdị siri ike ma dịte aka, chọrọ ụlọ ọgwụ na nchịkwa glucose ruo ọtụtụ ụbọchị. Hypoglycemia na-etolitekarị nri nwere kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị alcoholụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge. Iji zere mmepe nke hypoglycemia, a chọrọ nlezianya na nhọrọ nke usoro onunu ogwu, yana inye onye ọrịa ozi zuru ezu gbasara ọgwụgwọ a tụrụ aro. Site na iji oke oke nke anụ ahụ na nke mmetụta uche, mgbe ị na-agbanwe nri, ịhazigharị ọgwụ nke Glimecomb dị mkpa.

Karịsịa mmetụta nke ọgwụ hypoglycemic bụ ndị agadi, ndị ọrịa na-anaghị enweta nri edozi, yana ọnọdụ adịghị ike, ndị ọrịa na-ata ahụhụ site na enweghi nri.

Beta-blockers, clonidine, reserpine, guanethidine na-enwe ike ikpuchi ngosipụta nke ọrịa hypoglycemia.

E kwesiri ịdọ ndị ọrịa aka na ntị gbasara ịba ụba nke hypoglycemia n'ihe banyere ị etụ ọgwụ ethanol (mmanya), ọgwụ mgbochi mkpali (NSAIDs), na agụụ.

Site na nnukwu ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile, ọ nwere ike ịdị mkpa ịkagbu ọgwụ hypoglycemic ọgwụ ma nyekwa ọgwụ insulin.

N’ime ọgwụgwọ, ọ dị mkpa inyocha akụrụ. A ga - ebu ụzọ kpebie lactate na plasma ma ọ dịkarịa ala ugboro abụọ n'afọ, yana ọdịdị nke myalgia. Site na mmepe nke lactic acidosis, achọrọ ịkwụsị ọgwụgwọ.

Oge awa 48 tupu ịwa ahụ ma ọ bụ nchịkwa ọgbụgba nke ihe na-alụ ọgụ ọrịa iodine, ịhapụ Glimecomb kwesịrị ịkwụsị. A na-atụ aro ọgwụgwọ ka ịmaliteghachi mgbe awa 48 gachara.

Megide usoro ọgwụgwọ na Glimecomb, onye ọrịa ahụ ga-ahapụ ị alcoholụ mmanya na / ma ọ bụ ọgwụ na nri.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge ọgwụgwọ Glimecomb, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

Ngkwalite mmetụta hypoglycemic nke ọgwụ Glimecomb ka ejiri ya mee ihe n’otu oge na enzyme angiotensin-converting (ACE), ọgwụ mgbochi H2-receptor blockers (cimetidine), ọgwụ antifungal (miconazole, fluconazole), NSA (clofibrate, bezafibrat), ọgwụ mgbochi TB (ethionamide), salicylates, coumarin anticoagulants, steroid anabolic, beta-blockers, monoa inhibitors. inoxidase (MAO), sulfonamides na-arụ ọrụ ogologo oge, ya na cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocasureine ,rimrimam, ihe ọzọ insulin), allopurinol, oxytetracycline.

A na-ahụta mbelata hypoglycemic nke ọgwụ Glimecomb site na iji ya mee ihe n'otu oge na barbiturates, glucocorticosteroids (GCS), ndị na-ahụ maka agrenistgic (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), ndị na-egbochi ngwa ngwa na-egbochi ọgwụ na-amị amị amị am asparaginase, ya na baclofen, danazole, diazoxide, isoniazid, ya na morphine, rhytodrine, salbutamol, terbutaline, ya na glucagon, rifampicin, ya na g rmonami thyroid, lithium salts, na elu doses nke nicotinic acid, chlorpromazine, onu gbochie afọ na estrogens.

Na-eme ka ihe ọghọm ventricular extrasystole dị na ndabere nke gbasara glycosides cardiac.

Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ethanol (mmanya) na - eme ka ohere nke lactic acidosis belata.

Metformin belatara itinye uche kachasị na plasma na ọkara ndụ furosemide site na 31 na 42.3%, otu isi.

Furosemide na-eme ka mmelite metformin kacha karịa site na 22%.

Nifedipine na-abawanye nnabata, na-agbada ngwa ngwa nke metformin.

Ọgwụ cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro tubular na, site na usoro ọgwụgwọ ogologo oge, nwere ike ime ka mkpokọ metformin dị ukwuu na plasma ọbara dị 60%.

Analogs nke ọgwụ Glimecomb

Glimecomb enweghị usoro analogues maka ihe arụ ọrụ.

Analogs maka ọgwụgwọ ọgwụgwọ (ọgwụ maka ọgwụgwọ nke ọrịa mellitus na-abụghị insulin na-adabere):

Avandamet
Avandia
Adebite
Amaril
Anvistat
Antidiab
Arfazetin,
Akpa,
Ndị Betani
Biosulin P,
Vazoton
Victoza
Vipidia,
Galvus
Glemaz
Glibamide
Glibenez
Glibomet,
Glidiab
Glucophage,
Glurenorm,
Daonil
Ọrịa mamịrị
Diastabol,
Dibikor
Insulin s
Ndepụta aha
Metfogamma,
Metformin
Mikstard Penfill,
Monotard MC,
Neovitel
NovoMix Penfill,
Noliprel A
Orsoten
Pankragen,
Pensulin,
Pioglar
Predian
Presartan
Ntugharị
Saxenda
Silubin Retard,
Siofor
Starlix
Telzap
Telsartan
Ihe omumu
Mpempe akwụkwọ,
Chitosan
Chlorpropamide
Humalog,
Humulin
Cigapan
Endur-B,
Erbisol
Euglucon,
Januvius
Yanumet Long.

Echiche nke Endocrinologist

Ọgwụ antidiabetic Glimecomb nwere ndepụta dị ntakịrị na-egosi na contraindications dị obosara. Ya mere, odi nkpa ichoro ya mgbe mgbe. Ọbara nye onye ọrịa ọ bụla nwere ụdị ọrịa shuga mellitus abụọ ka m họrọ n’otu n’otu. N'ime ndị ọrịa na-agbaso iwu nke iwere Glimecomb, mmeghachi omume ọjọọ na-etolitekarị obere karịa ndị ọrịa ahụ anaghị agbaso ndụmọdụ ndị ahụ. Ọbụlagasị ọnọdụ nke hypoglycemia siri ike na enweghị mmerụ ahụ ewerewo na omume m mgbe a ga-enyerịrị ndị ụlọ ọgwụ n'ụlọ ọgwụ. Mana n’ozuzu, enwere m ike ikwu na ndị ọrịa na-anabata ọgwụ ahụ nke ọma.

Ihe ngosi maka ojiji

- ụdị shuga mellitus nke 2 (nke na-abụghị insulin) na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na usoro ọgwụgwọ gara aga na metformin ma ọ bụ gliclazide,

- iji dochie usoro ọgwụgwọ gara aga site na ọgwụ abụọ (metformin na gliclazide) na ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa mellitus (na-abụghị insulin) na ọkwa glucose ọbara dị mma.

Ihe ngbanwe

- ụdị shuga mellitus (afọ insulin),

- oke nsogbu gbasara akụrụ,

- nnukwu ọnọdụ nke nwere ike ibute mgbanwe na ọrụ akụrụ: akpịrị ịkpọ nkụ, ọrịa siri ike, ujo,

- ọrịa ukwu ma ọ bụ nke na-adịghị ala ala nke gụnyere hypoxia anụ ahụ: nkụchi obi, ọrịa iku ume, ndagwurugwu myocardial, ujo,

- lactation (inye ara),

- ọnọdụ chọrọ insulin ọgwụ, gụnyere ọrịa na-efe efe, nnukwu ihe ịwa ahụ, mmerụ ahụ, oke ọkụ,

intoụbiga mmanya ókè,

- lactic acidosis (gụnyere akụkọ ihe mere eme),

- iji maka opekata mpe, tupu elekere iri anọ na asatọ tupu ma ọ bụ n'ime elekere 48 ka ị mụchara nyocha redio ma ọ bụ X-ray na ntinye nke ayodiin nwere ihe dị iche,

- esoro na nri kalori (erughi 1000 cal / day),

- Hypersensitivity na mmiri ọgwụ,

- Hypersensitivity na usoro ndị ọzọ dị na sulfonylurea.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-a oụ ọgwụ ahụ n’oge a na-eri nri ma ọ bụ ozugbo nri. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ogologo glucose ọbara.

Usoro izizi a na-abụkarị mbadamba 1-3 / ụbọchị yana nhọrọ nwayọ nwayọ nke ọgwụ ruo mgbe a ga-enweta ụgwọ nkwụghachi nke ọrịa ahụ. Oke kachasị kwa ụbọchị bụ mbadamba ise.

A na-a theụ ọgwụ ahụ ugboro abụọ / ụbọchị (ụtụtụ na mgbede).

Nsonaazụ

Site na usoro endocrine: hypoglycemia (nke megidere usoro dosing regimen na nri na-ezighi ezi) - isi ọwụwa, ịda mba, agụụ, mmụba ọsụsọ, ike ọgwụgwụ, palpitations, ọgbụgba, njiri nkwaghari nke mmeghari, nsogbu akwara ozi nwa oge, na ịba ụba nke hypoglycemia, ọnwụ nke njide onwe onye ga-ekwe omume, ọnwụ nke mmụọ.

Site n'akụkụ nke metabolism: n'ọnọdụ ụfọdụ - lactic acidosis (adịghị ike, myalgia, nsogbu nke akụkụ iku ume, ụra, afọ mgbu, hypothermia, ọbara mgbali, bradyarrhythmia).

Site na usoro digestive: dyspepsia (ọgbụgbọ, afọ ọsịsa, mmetụta nke oke na epigastrium, "ụtọ" n'ọnụ), belatara agụụ (ogo nke mmeghachi omume ndị a na-ebelata ọgwụ mgbe ị na-eri nri), ịba ọcha n'anya, cholestatic jaundice (iwere ọgwụ dị mkpa) , mmụba nke ọrụ nke hepatic transaminases, alkaline phosphatase.

Site na sistemu hemopoietic: adịkarịghị - mgbochi nke ụmị ọkpụkpụ (anaemia, thrombocytopenia, leukopenia).

Mmeghachi omume nfụkasị ahụ: itching, urticaria, flop na maculopapular.

Ndị ọzọ: enweghi ike ịhụ ụzọ.

Ntụziaka pụrụ iche

Enwere ike inye glimecomb naanị ndị ọrịa na-anata nri mgbe niile, nke na-agụnye nri ụtụtụ ma na-enye ezigbo carbohydrates.

Mmekorita

Strekwado mmetụta hypoglycemic nke ọgwụ Glimecomb ka ejiri ya mee ihe n'otu oge na ndị na-egbochi ACE (captopril, enalapril), ndị na-egbochi ọgwụ H2-receptor (cimetidine), ọgwụ antifungal (miconazole, fluconazole), NSAIDs (phenylbutazoneba, oplapla, sitpooppopopo, alappoplase, alappopopoppepapepapopapo] ), ọgwụ mgbochi (TB) (ethionamide), salicylates, ọgwụ coumarin anticoagulants, steroid anabolic, beta-blockers, MAO inhibitors, sulfonamides na-arụ ọrụ ogologo oge. , ya na cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, ihe mgbochi nzuzo tubular, reserpine, bromocriptine, na-enupụrụ, pyridoxine, ya na ọgwụ ndị ọzọ. .

A na-ahụta mbelata hypoglycemic nke ọgwụ Glimecomb site na iji ya mee ihe na barbiturates, GCS, ọgwụ agrenergic (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), na-eji ngwa mkpọchi mkpụrụ ndụ klọọkụ, carbon anhydrase inhibitors, acetazolamide diide diides diaging. ya na baclofen, danazole, diazoxide, isoniazid, ya na morphine, ritodrin, salbutamol, terbutaline, ya na glucagon, rifampicin, ya na homonu thyroid. s, nnu nke lithium, nwere nnukwu nicotinic acid, chlorpromazine, ọgwụ mgbochi mkpị na estrogens.

Na-eme ka ihe ọghọm ventricular extrasystole dị na ndabere nke gbasara glycosides cardiac.

Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ethanol na - eme ka o nwee ohere nke lactic acidosis.

Ajuju, azịza, nyocha banyere ọgwụ Glimecomb

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Akwụkwọ ntuziaka

Onye nwe asambodo ndenye aha: Chemical na ọgwụ ọgwụ Combine Akrikhin, OJSC (Russia)
Onye nnọchi anya: Akrikhin OJSC (Russia)

Mpempe mwepụta
Mbadamba 40 mg + 500 mg: 60 pcs.

Ngwakọta ọgwụ hypoglycemic ejikọtara ọnụ maka iji ọnụ mee ihe. Glimecomb® bụ ngwongwo abụọ nke ndị na-eme ọnụ hypoglycemic nke otu biguanide na otu sulfonylurea.

Ọ nwere palọ na extrapancreatic edinam.

Glyclazide bụ usoro sitere na sulfonylurea. Na-akpali mmiri ọgwụ insulin site na pancreas, na-eme ka ahụrịị anụ ahụ na-emetụta insulin. Na-akpali ọrụ nke enzymes intracellular - muscle glycogen synthetase. Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ, na --belata oge dị iche site na oge iri nri na mmalite insulin insulin, ma belata hyperglycemia postprandial. Na mgbakwunye na emetụta metabolism metabolism, ọ na - emetụta microcirculation, na - ebelata nrapado platelet na nchịkọta, na - egbu oge mmepe nke parietal thrombosis, na - egbochi vaskụla permeability ma na - egbochi mmepe microthrombosis na atherosclerosis, na - eweghachi usoro nke physiological parietal fibrinolysis, ma na - agbaghaghachi mmeghachi omume akwara. Na-eme ka mmepe nke ọrịa mamịrị na-arịa ọrịa retinopathy na-abụghị nke na-aba ụba, na-arịa nephropathy na-arịa ọrịa ogologo oge, a na-ahụta mbelata dị ukwuu na proteinuria. Ọ naghị ebute mmụba n’arụ ahụ, n’ihi ọ nwere mmetụta kachasị ukwuu na mmalite nke insulin insulin ma ghara ịkpata hyperinsulinemia, na-enyere aka belata oke ahụ n'ahụ ndị ọrịa buru ibu, na-agbaso nri kwesịrị ekwesị.

Metformin bụ otu nke biguanides. Ọ na --ebelata mkpụkọ glucose n'ime ọbara site na igbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na ngụgụ nri ma na - abawanye uru ya na anụ ahụ. Ọ na-ebelata ịta nke triglycerides, cholesterol na LDL (kpebisiri ike na afọ efu) na ọbara ọbara na adịghị agbanwe ntinye uche nke lipoproteins nke ịdị iche iche. Ọ na - enyere aka ịgbatị ma ọ bụ belata ahụ. Na enweghị insulin n'ime ọbara, a naghị egosipụta mmetụta ọgwụgwọ. Ọkpụkpụ hypoglycemic anaghị akpata. Ọ na - eme ka akwara fibrinolytic dị n'ọbara n'ihi mkpesa nke onye na - egbochi nnabata profibrinolysin (plasminogen) ụdị anụ ahụ.

Mgbu na nkesa

Mgbe nchịkwa ọnụ gachara, mmịcha ahụ dị elu. Mgbe ewere ya na ọgwụ nke 40 mg C max na plasma ọbara ruru mgbe awa 2-3 gachara 2-3 μg / ml. Ihe mgbochi protin Plasma bụ 85-97%.

Metabolism na ntụpọ

Metabolized na imeju. T 1/2 - 8-20 awa 9. Ọ bụ n’arụ dị ka ụdị metabolites site na akụrụ ya - 70%, site na eriri afọ - 12%.

N'ime ndị ọrịa agadi, anaghị ahụ mgbanwe mgbanwe dị ukwuu na ọgwụ ọgwụ.

Mgbu na nkesa

Mgbe nchịkwa ọnụ gachara, mmịpụta ahụ bụ 48-52%. Anọrọ ngwa ngwa si na nri diges. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%. C max na plasma ọbara ruru ka 1.81-2.69 h ma ọ gafere 1 μg / ml. Ceptionnabata nri na-ebelata C max na plasma site na 40% ma belata ọganiizu ya na nkeji 35. Mgbakwunye protein Plasma bụ nke ileghara anya. Metformin nwere ike ịgbakọta na mkpụrụ ndụ ọbara uhie.

T 1/2 bụ awa 6.2. Ọ bụ akụrụ na-apịpụta ya, ọkachasị adịghị agbanwe agbanwe (ihe nhicha na ngwakọta nke mmiri) na site na eriri afọ (ihe ruru 30%).

- ụdị shuga mellitus nke 2 (nke na-abụghị insulin) na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na ọgwụgwọ mbụ ya na metformin ma ọ bụ gliclazide,

- iji dochie usoro ọgwụgwọ gara aga site na ọgwụ abụọ (metformin na gliclazide) na ndị ọrịa nwere ụdị shuga mellitus 2 (nke na-abụghị insulin) na ọkwa glucose ọbara dị mma ma na-achịkwa nke ọma.

A na-a theụ ọgwụ ahụ ugboro abụọ / ụbọchị (ụtụtụ na mgbede).

Site n'akụkụ nke metabolism: n'ọnọdụ ụfọdụ - lactic acidosis (adịghị ike, myalgia, nsogbu nke akụkụ iku ume, ụra, afọ mgbu, hypothermia, ọbara mgbali, bradyarrhythmia).

Site na sistemu hemopoietic: adịkarịghị - mgbochi nke ụmị ọkpụkpụ (anaemia, thrombocytopenia, leukopenia).

Mmeghachi omume nfụkasị ahụ: itching, urticaria, flop na maculopapular.

Ndị ọzọ: enweghi ike ịhụ ụzọ.

Ọ bụrụ na nsonaazụ ndị ọzọ, a ga-belata dose ahụ ma ọ bụ kwụsị ọgwụ ahụ ruo nwa oge.

Nsonaazụ ndị ọzọ a na-ahụkarị na njikọta sulfonylurea: erythropenia, agranulocytosis, hemolytic anaemia, pancytopenia, vasculitis nfụkasị, ọrịa imeju na-egbu ndụ.

- ụdị shuga mellitus (afọ insulin),

- arịa ọrịa mamịrị

- oke nsogbu gbasara akụrụ,

- nnukwu ọnọdụ nke nwere ike ibute mgbanwe na ọrụ akụrụ: akpịrị ịkpọ nkụ, ọrịa siri ike, ujo,

- ọrịa ukwu ma ọ bụ nke na-adịghị ala ala nke gụnyere hypoxia anụ ahụ: nkụchi obi, ọrịa iku ume, ndagwurugwu myocardial, ujo,

- lactation (inye ara),

- nhazi nke miconazole,

- ọnọdụ chọrọ insulin ọgwụ, gụnyere ọrịa na-efe efe, nnukwu ihe ịwa ahụ, mmerụ ahụ, oke ọkụ,

intoụbiga mmanya ókè,

- lactic acidosis (gụnyere akụkọ ihe mere eme),

- iji maka opekata mpe, tupu elekere iri anọ na asatọ tupu ma ọ bụ n'ime elekere 48 ka ị mụchara nyocha redio ma ọ bụ X-ray na ntinye nke ayodiin nwere ihe dị iche,

- esoro na nri kalori (erughi 1000 cal / day),

- Hypersensitivity na mmiri ọgwụ,

- Hypersensitivity na usoro ndị ọzọ dị na sulfonylurea.

A naghị atụ aro iji ọgwụ ahụ mee ihe na ndị ọrịa gaferela afọ 60 ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke lactic acidosis.

Iji nlezianya kpachara anya, a ga-eji ọgwụ ahụ mee ihe banyere ọrịa febrile, adrenal insufficiency, hypofunction of the face pituitary, ọrịa nke akwara gland na arụ ọrụ.

Iji ọgwụ a glimecomb ® n'oge ime dị ime. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n'ihe gbasara afọ ime n’oge ịlụ ọgwụ Glimecomb ®, ekwesịrị iwepụ ya na ọgwụ insulin.

A na-egbochi Glimecomb ind n'ime ara, ebe ọ bụ na mmiri ara ehi nwere ike ịmị mmiri ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Ọrịa: lactic acidosis ga - ekwe omume (n'ihi na metformin bụ akụkụ nke ọgwụ), hypoglycemia.

Ọgwụgwọ: mgbe ihe mgbaàmà nke lactic acidosis pụtara, ịkwesịrị ịkwụsị ị .ụ ọgwụ ahụ. Lactic acidosis bụ ọnọdụ chọrọ nlekọta ahụike mberede, a na-eme ọgwụgwọ n'ụlọ ọgwụ. Ọgwụ kachasị dị irè bụ ịba ọcha n'anya.

Site na iji hypoglycemia dị nro ma ọ bụ na-agafeghị oke, a na-eji ọnụ gwuo glucose (dextrose) ma ọ bụ mmiri shuga. N'ihe banyere hypoglycemia siri ike (enweghị mmerụ), 40% dextrose (glucose) ma ọ bụ iv glucagon, i / m ma ọ bụ s / c ka a na-eduzi iv. Mgbe ọ nwetasịrị onwe ya, a ga-enyerịrị onye ọrịa ahụ nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Strekwado mmetụta hypoglycemic nke ọgwụ Glimecomb ® ka ejiri ya mee ihe n'otu oge na ndị na - egbochi ACE (captopril, enalapril), ndị na - anabata ọgwụ mgbochi H 2 (cimetidine), ọgwụ antifungal (miconazole, fluconazole), NSAIDs (phenylbutazonebode, oxalappolon) , bezafibrat), ọgwụ mgbochi TB (ethionamide), salicylates, coumarin anticoagulants, steroid anabolic, beta-blockers, MAO inhibitors, sulfonamides na-arụ ọrụ ogologo oge. vii, ya na cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, ndị na-egbochi nzuzo, reserpine, bromocriptine, na-enupụ isi, pyridoxine, ọgwụ ndị ọzọ, Ọkpụkpụ oxygen.

A na-ahụta mbelata hypoglycemic nke ọgwụ Glimecomb ® site na iji ya mee ya na barbiturates, GCS, ọgwụ agrenergic (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), na-eji ngwa mkpọchi mkpụrụ ndụ calcium, carbonic anhydrase inhibitors, acetyl azidemide ditics. , ya na baclofen, danazole, diazoxide, isoniazid, ya na morphine, ritodrin, salbutamol, terbutaline, ya na glucagon, rifampicin, ya na homonu thyroid. zy, lithium salts, na elu doses nke nicotinic acid, chlorpromazine, onu gbochie afọ na estrogens.

Na-eme ka ihe ọghọm ventricular extrasystole dị na ndabere nke gbasara glycosides cardiac.

Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ethanol na - eme ka o nwee ohere nke lactic acidosis.

Metformin belatara C max na plasma na T 1/2 nke furosemide site na 31 na 42.3%, n'otu n'otu.

Furosemide mụbara C max metformin na 22%.

Nifedipine na-abawanye nnabata, na-abawanye C max na plasma ọbara, na-ebelata iweze nke metformin.

Ọgwụ cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi nke usoro tubular na, site na usoro ọgwụgwọ ogologo oge, nwere ike ime ka C max metformin na plasma ọbara dị 60%.

Contraindicated na imeju ọdịda.

Contraindicated n’ime nnukwu nsogbu gbasara akụrụ, ọnọdụ tara akpụ nke nwere ike ibute mgbanwe n’ọrụ gbasara akụrụ: akpịrị ịkpọ nkụ, ọrịa siri ike, ujo.

Ọgwụ Glimecomb ® ka a na-eme naanị na mgbakwunye na obere kalori, nri nwere obere carb. Ọ dị mkpa ịdị na-enyocha ọkwa glucose mgbe niile n'ọbara na afọ na-enweghị nri na mgbe erichara nri, ọkachasị na ụbọchị mbụ ọgwụgwọ ọgwụ.

Enwere ike ịnye glimecomb ® naanị ndị ọrịa na-eri nri mgbe niile, nke na-agụnye nri ụtụtụ ma na-enye ezigbo carbohydrates.

Karịsịa mmetụta nke ọgwụ hypoglycemic bụ ndị agadi, ndị ọrịa na-anaghị enweta nri edozi, yana ọnọdụ adịghị ike, ndị ọrịa na-ata ahụhụ site na enweghi nri.

Beta-blockers, clonidine, reserpine, guanethidine na-enwe ike ikpuchi ngosipụta nke ọrịa hypoglycemia.

E kwesiri ịdọ ndị ọrịa aka na ntị gbasara ike ịba ụba hypoglycemia n'ọnọdụ ethanol, NSAIDs, na agụụ.

Site na nnukwu ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile, ọ nwere ike ịdị mkpa ịkagbu ọgwụ hypoglycemic ọgwụ ma nyekwa ọgwụ insulin.

Oge awa 48 tupu a waa ya ahụ ma ọ bụ na / na ntinye nke onye na-ahụ maka rediopaf nke iodine, ọgwụ Glimecomb ® kwesịrị ịkwụsị. A na-atụ aro ọgwụgwọ ka ịmaliteghachi mgbe awa 48 gachara.

Megide usoro ọgwụgwọ na Glimecomb ®, onye ọrịa ahụ ga-ahapụ ị alcoholụ mmanya na / ma ọ bụ ọgwụ ethanol nwere.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Ọgwụ site na-acha ọcha na-acha ọcha na-acha uhie uhie ma ọ bụ nke na-acha odo odo, nke dị larịị, nke nwere chamfer na notch, a na-anabata ala.

Taabụ 1
gliclazide	40 mg
metformin hydrochloride	500 mg

Ndị ọkachamara: sorbitol, povidone, sodium croscarmellose, magnesium stearate.

10 PC. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Ngwakọta ọgwụ hypoglycemic ejikọtara ọnụ maka iji ọnụ mee ihe. Glimecomb® bụ ngwongwo abụọ nke ndị na-eme ọnụ hypoglycemic nke otu biguanide na otu sulfonylurea.

Ọ nwere palọ na extrapancreatic edinam.

Glyclazide - usoro sulfonylurea. Na-akpali mmiri ọgwụ insulin site na pancreas, na-eme ka ahụrịị anụ ahụ na-emetụta insulin. Na-akpali ọrụ nke enzymes intracellular - muscle glycogen synthetase.

Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ, na --belata oge dị iche site na oge iri nri na mmalite insulin insulin, ma belata hyperglycemia postprandial.

Na mgbakwunye na emetụta metabolism metabolism, ọ na - emetụta microcirculation, na - ebelata nrapado platelet na nchịkọta, na - egbu oge mmepe nke parietal thrombosis, na - egbochi vaskụla permeability ma na - egbochi mmepe microthrombosis na atherosclerosis, na - eweghachi usoro nke physiological parietal fibrinolysis, ma na - agbaghaghachi mmeghachi omume akwara. Na-eme ka mmepe nke ọrịa mamịrị na-arịa ọrịa retinopathy na-abụghị nke na-aba ụba, na-arịa nephropathy na-arịa ọrịa ogologo oge, a na-ahụta mbelata dị ukwuu na proteinuria. Ọ naghị ebute mmụba n’arụ ahụ, n’ihi ọ nwere mmetụta kachasị ukwuu na mmalite nke insulin insulin ma ghara ịkpata hyperinsulinemia, na-enyere aka belata oke ahụ n'ahụ ndị ọrịa buru ibu, na-agbaso nri kwesịrị ekwesị.

Metformin nke otu biguanides. Ọ na --ebelata mkpụkọ glucose n'ime ọbara site na igbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na ngụgụ nri ma na - abawanye uru ya na anụ ahụ.

Ọ na-ebelata ịta nke triglycerides, cholesterol na LDL (kpebisiri ike na afọ efu) na ọbara ọbara na adịghị agbanwe ntinye uche nke lipoproteins nke ịdị iche iche. Ọ na - enyere aka ịgbatị ma ọ bụ belata ahụ. Na enweghị insulin n'ime ọbara, a naghị egosipụta mmetụta ọgwụgwọ. Ọkpụkpụ hypoglycemic anaghị akpata.

Ọ na - eme ka akwara fibrinolytic dị n'ọbara n'ihi mkpesa nke onye na - egbochi nnabata profibrinolysin (plasminogen) ụdị anụ ahụ.

Mlọ ọgwụ

Mgbu na nkesa

Mgbe nchịkwa ọnụ gachara, mmịcha ahụ dị elu. Mgbe ewere ya na ọgwụ nke 40 mg Cmax na plasma ruru mgbe awa 2-3 gachara 2-3 μg / ml. Ihe mgbochi protin Plasma bụ 85-97%.

Metabolism na ntụpọ

Metabolized na imeju. T1 / 2 - awa 8-20. Ọ bụ ọkachasị n'ụdị metabolites site na akụrụ - 70%, site na eriri afọ - 12%.

N'ime ndị ọrịa agadi, anaghị ahụ mgbanwe mgbanwe dị ukwuu na ọgwụ ọgwụ.

Mgbu na nkesa

Mgbe nchịkwa ọnụ gachara, mmịpụta ahụ bụ 48-52%. Anọrọ ngwa ngwa si na nri diges. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%. Cmax na plasma ọbara ruru ka 1.81-2.69 h ma ọ gafere 1 μg / ml. Ceptionnabata nri na-ebelata Cmax na plasma site na 40% ma belata ọganiizu ya na minit 35. Mgbakwunye protein Plasma bụ nke ileghara anya. Metformin nwere ike ịgbakọta na mkpụrụ ndụ ọbara uhie.

T1 / 2 bụ awa 6.2. Ọ bụ akụrụ na-emegharị ya, ọkachasị na-agbanweghi agbanwe (mmiri nhicha na ngwakọta nke mmiri) yana site na eriri afọ (ihe ruru 30%).

- ụdị shuga mellitus nke 2 (nke na-abụghị insulin) na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na ọgwụgwọ mbụ ya na metformin ma ọ bụ gliclazide,

Dodoụbiga ya ókè

Ọrịa lactic acidosis ga - ekwe omume (ebe metformin bụ akụkụ nke ọgwụ), hypoglycemia.

Ọgwụgwọ: ọ bụrụ na mgbaama nke lactic acidosis apụta, kwụsị ị theụ ọgwụ. Lactic acidosis bụ ọnọdụ chọrọ nlekọta ahụike mberede, a na-eme ọgwụgwọ n'ụlọ ọgwụ. Ọgwụ kachasị dị irè bụ ịba ọcha n'anya.

Mkparịta ụka ọgwụ ọjọọ

Na-eme ka ihe ọghọm ventricular extrasystole dị na ndabere nke gbasara glycosides cardiac.

Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ethanol na - eme ka o nwee ohere nke lactic acidosis.

Metformin belatara Cmax na plasma na T1 / 2 nke furosemide site na 31 na 42.3%, n'otu n'otu.

Furosemide na-abawanye Cmax nke metformin site na 22%.

Nifedipine na-abawanye nnabata, na-abawanye Cmax na plasma ọbara, na-ebelata excretion nke metformin.

Ime na lactation

Glimecomb na - enye ndị ara ara, ebe ọ bụ na mmiri ara ehi nwere ike ịmị mmiri ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Usoro na ọnọdụ nchekwa

Ndepụta B. Ekwesịrị ịchekwa ọgwụ ahụ ka ụmụaka ghara iru, kpọnwụọ ya, na-echebe ya site na ọkụ, na-enweghị okpomọkụ karịa ogo 25 Celsius. Ndụ shelf bụ afọ 2.

Nkọwa nke ọgwụ GLIMECOMB sitere na ntuziaka akwadoro maka ojiji ndị ọrụ mepere emebere ya.

Chọta ahụhụ? Họrọ ya wee pịa Ctrl + Tinye.

Iwu nke ị takingụ ọgwụ Glimecomb yana ọgwụ analog

Glimecomb na-ezo aka ọgwụ ejiri maka ụdị shuga 2.

Ngwá ọrụ nwere ihe hypoglycemic jikọtara ọnụ.

Mgbe ị theụsịrị ọgwụ ahụ, a na-ahụta nhazi nke ọkwa glucose dị n'ọbara onye ọrịa.

Ozi izugbe, ihe mejupụtara na ụdị ntọhapụ

Ọgwụ ahụ akọwapụtara na-ezo aka n'ụgwọ ndị ọrịa hypoglycemic ejiri ọnụ. Ngwá ọrụ ahụ nwere mmetụta jikọtara ọnụ. Na mgbakwunye na mmetụta belata shuga, Glimecomb nwere mmetụta nke pancreatic. N'ọnọdụ ụfọdụ, ọgwụ ahụ nwere mmetụta extrapancreatic.

Ngwakọta ọgwụ a nwere Metformin hydrochloride na ọnụọgụ 500 mg na Gliclazide - 40 mg, yana sorbitol na ssum silium nke na-ebu mmiri. Na obere ego, magnesium stearate na povidone dị na ọgwụ.

Ọgwụ dị n'ụdị mbadamba cylindrical na ọcha, ude ma ọ bụ ndo odo. Maka mbadamba ihe, a na-anabata marbling. Erere nwere ihe egwu na bevel.

A na-ere Glimecomb na mbadamba 10 n'ime paịlị. Otu mkpọ nwere ngwugwu 6.

Pharmacology na pharmacokinetics

Glimecomb bụ ọgwụ ọgwụ ejikọtara ọnụ nke ndị na - ejikọ hypoglycemic nke ndị otu biguanide na ọgwụ sulfonylurea.

Ejiri mara onye na-anọchite anya onye na-ahụ anya.

Gliclazide bụ otu n'ime isi ihe dị na ọgwụ ahụ. Ọ bụ usoro nke sulfonylurea.

emeputa insulin
ịba mgbanye glucose ọbara,
ibelata platelet, na-egbochi ikebe ọbara ọgbụgba ọbara,
normalization nke vaskụla permeability.

Gliclazide na - egbochi ihe microthrombosis. Mgbe ịedụ ọgwụ ogologo oge na ndị ọrịa nwere ọrịa nephropathy, a na-achọpụta mbelata proteinuria (ọnụnọ protein na mmamịrị).

Gliclazide na-emetụta oke ibu nke onye ọrịa na-a theụ ọgwụ. Site na nri kwesiri ekwesi na ndi ọrịa oria na - ewere Glimecomb, a na - ahụtalata oke ibu.

Metformin, nke bụ akụkụ nke ọgwụ ahụ, na-ezo aka n'òtù biguanide. Ihe ahụ na-ebelata ọ̀tọ glucose n’ọbara, na-enyere aka mee ka ike gwụ usoro dị n’itinye glucose si n’afọ na eriri afọ. Metformin na-enyere aka ịgbalite ngwa ngwa iji glucose site na anụ ahụ.

Ihe na-ebelata cholesterol, obere lipoproteins dị ala. N'okwu a, Metformin anaghị emetụta ọkwa nke lipoproteins nke njupụta dị iche. Dị ka Gliclazide, ọ na-ebelata ịdị arọ nke onye ọrịa.

Ọ nweghị mmetụta ọ bụla na enweghi insulin n'ime ọbara. Emeghị ka ntinye hypoglycemic mmeghachi omume. Gliclazide na metformin na-anabata ma wepu ya na onye ọrịa.

Ihe eji amata Gliclazide bu ihe kariri nke Metformin.

Mkpuchi Gliclazide kacha n'ọbara erute mgbe awa atọ gachara ọgwụ a malitere. A na-ewepụta ihe ahụ n’akpa akụrụ (70%) na eriri afọ (12%). Iwepu ọkara ndụ na-eru awa iri abụọ.

Bioavailability nke Metformin bụ 60%. Ihe ahụ na-agbakọta n’ịgha mkpụrụ ndụ ọbara uhie. Nkeji ọkara bụ 6 awa. Drawepu iwe ahụ na-aputa ihe site na akụrụ, yana eriri afọ (30%).

Ihe ngosi na contraindications

A na-atụ aro ọgwụ ahụ maka ndị ọrịa mamịrị nwere ọrịa shuga 2 ọ bụrụ:

ọgwụgwọ izizi yana nri na mmega ahụ arụghị arụ ọrụ kwesịrị ekwesị.
enwere mkpa iji dochie ọgwụ ịchikọta na mbụ iji Gliclazide na Metformin na ndị ọrịa nwere ọkwa glucose ọbara dị ala.

Ejiri ọgwụ ahụ gosipụtara ọtụtụ ọgwụ contraindications, n'etiti ndị:

ọnụnọ nke ọrịa shuga 1,
nnabata nke ọgwụ ahụ,
arụ ọrụ akụrụ
tụụrụ ime
imeju imeju
lactic acidosis,
obi obara
ọrịa mamịrị
lactation
ọrịa dị iche iche
infarction myocardial
Ọrịa porphyrin
precca ọrịa mamịrị
ihe ogwugwo gara aga,
oge onye ọrịa na-eme nyocha ray-ray na nyocha na-eji redioisotopes na ntinye nke ndị na-emegide iodine (amachibidoro ị were ụbọchị abụọ tupu ọmụmụ ndị a),
nnukwu mmerụ ahụ
Ọnọdụ oke ụjọ maka ụdị ọrịa obi na akụrụ,
okuku ume iku ume
mmanya na-egbu egbu,
ọbara shuga dị ala (hypoglycemia),
nnukwu ọrịa akụrụ
egbu egbu egbu,
Anụ na-ere ọkụ n’arụ,
rube isi na ndị ọrịa nwere nri hypocaloric,
na-ewere miconazole,
ọrịa mamịrị ketoacidosis.

Echiche nke ndị ọkachamara na ndị ọrịa

Site na nyocha ndị ọrịa, enwere ike ikwubi na Glimecomb na-ebelata shuga ọbara nke ọma ma na-anabatakwa nke ọma, Otú ọ dị, ndị dọkịta na-ekwusi ike na ịkpachara anya ya n'ihi ọtụtụ nsonaazụ ya.

A na-enye ọgwụ ndị akọwapụtara site na ndenye ọgwụ. Ọnụ ahịa ya dị site na 440-580 rubles. Ọnụahịa nke ndị mmekọ ụlọ ọzọ sitere na 82 ruo 423 rubles.

Akwukwo ndi ozo ndi ozo choro

Glimecomb: ntuziaka maka ojiji, ọnụahịa, nyocha, analogues

Ọgwụ a na-ekwu okwu ọnụ, nke chọrọ ịchịkwa ọkwa nke glucose na ọbara onye ọrịa nwere ụdị shuga 2.

Bgwakọta ma Metformin na Glyclazide, Glimecomb bụ ezigbo ihe ngwọta maka nsogbu nke glucose ọbara, njikwa nke kwesịrị ịdị mfe nchịkwa.

E kwuwerị, ngwá ọrụ a enweghị ike, yabụ adabaghị na ndị ọrịa na ọkwa shuga dị elu na-enweghị mgbagha. Ihe ndị a bụ ihe achọrọ nke a ga-agbaso mgbe ị na-a thisụ ọgwụ a.

Ngwa

A na-atụ aro Glimecomb maka ndị ọrịa nwere ọrịa shuga nke ụdị shuga 2.

Ọ dị mkpa na ọgwụ a na-ezubere ụdị ụdị ọrịa a mgbe ọrụ mmega ahụ na maapụ nri ahaziri iche anaghị ewetara nsonaazụ kwesịrị ekwesị.

Nke a pụtara na edere ọgwụ a ka ọ bụrụ na enwere usoro ọgwụgwọ siri ike na-aga nke ọma, na ijikọ ọgwụ abụọ (na-ejikarị metformin na gliclazide iche) yana mmega ahụ na nri.

N'oge ọgwụgwọ a na-eji Glimecomb, nlele oge niile maka ọkwa shuga ọbara nke onye ọrịa tupu nri ma mgbe ọ gachara nri dị mkpa (ekwesịrị ị attentiona ntị na izu mbụ nke nnabata).

Dị Mwepụta

Glimecomb nwere otu mpempe akwụkwọ n'ụdị mbadamba ihe. A na-ekewa ọgwụ ahụ site na iji otu esi eme ihe na otu ndị a:

na karama plastik na ngwugwu kaadiboodu. Otu vial a nwere ike ịnwe mbadamba 30, 60 ma ọ bụ 120,
N’ime kaadiboodu tinyere blisters nke mbadamba 10 n’ime otu. Otu ngwugwu nwere blisters 6,
N’ime kaadiboodu tinyere blisters nke mbadamba 20 n’ime otu. Otu ngwugwu dị otú ahụ nwere 5 blisters.

Mbadamba ndị ahụ n’onwe ha dị n’ụdị cylinder dị larịị, ọtụtụ mgbe ọcha (beige, marble ma ọ bụ odo na-anakwere). Erere nwere ihe egwu na bevel. Ihe mejupụtara nke Glimecomb gụnyere metformin na hydrochloride na ego nke 500 mg, yana glycoslide 40 mg. Na mgbakwunye, povidone, magnesium stearate, sorbitol na sodium croscarmellose dị na ntakịrị.

Mbadamba ụrọ dị naanị na ndenye ọgwụ.

Nsonaazụ

Mmetụta ndị na-achọghị ka enwere ike ịbịara gị mgbe ị na-ewere Glimecomb na-abụkarị n'ihi oke mmachi ya ma ọ bụ enweghị ike n'akụkụ ahụ onye ọrịa nwere ike ịdabere na ya.

Ọdịnaya nke usoro sulfonylurea na-eme ka ohere dị ukwuu nke nsonaazụ ya dịkwuo egwu.

Enweghi ike ịhọrọ onye ọrịa maka mmepe nke lactic acidosis, mịkọ na-agakọ, adịghị ike oge niile, oke ụra, yana ịbelata mgbu na mpaghara apịtị yana mbelata mgbali na akwara.

Ihe ndị a bụ mmetụta ndị a na-achọghị mgbe ị na-ewere Glimecomb:

mmepe nke hypoglycemia na lactocidosis nwere ihe mgbu mgbu niile dị mkpa,
ọdịdị nke afọ ọsịsa na flatulence,
Uche ị na-enwe mgbe nile afọ,
belata agụụ agụụ,
oge uto nke uto ọbara n'ọnụ na akpịrị,
mmepe nke ọrịa ọrịa imeju siri ike (ịba ọcha n'anya, wdg) dị ụkọ
mmeghachi omume nfụkasị ahụ na mmiri mejupụtara (urticaria, itching, etuto ahụ,
ọbara ọbara (ụdị rashes dị iche iche)
enwere nsogbu nke enweghi ike ịhụ ụzọ mgbe ị na-ewere Glimecomb.

Ọ bụrụ na ịnwere mgbaama ndị a dị n'elu, ị kwesịrị ịkpọtụrụ onye ọkachamara ozugbo.

Dabere ogo mmetụta nke ọghọm dị na ya, dọkịta kwesịrị belata usoro ị theụ ọgwụ ahụ ma ọ bụ dochie ya na nhọrọ a na-anabata nke ọma karị (hapụ kpamkpam iji Glimecomb).

N'ime ndị ahịa ọgwụ Russia, ọnụahịa nke Glimecomb dị iche site na 200 ruo 600 rubles, dabere na nkwakọ ngwaahịa na ọnụ ọgụgụ mbadamba dị na ya, yana onye na-ebubata ya na mpaghara ire ya.

Costgwọ ọgwụ a na-eme ka ọ bụrụ ọnụ ala maka ọnụ ọgụgụ buru ibu nke ndị bi, ya mere na ịchọrọ na ahịa ọgwụ. Ya mere, ọnụahịa dị elu na ụlọ ahịa n'ịntanetị maka mbadamba Glimecomb bụ 40 mg + 500 mg 450 rubles kwa ngwugwu, nke nwere mbadamba 60.

N'ime ụlọ ahịa ọgwụ network, ọnụ ahịa ọgwụ maka mbadamba 60 ga-abụ ihe 500-550 rubles.

Ihe ana - eme glimecomb bu ogwu ndia:

Gliformin (ihe dị ka 250 rubles maka mbadamba 60), ụkpụrụ nke ime ihe bụ nke Glimecomb, ihe mejupụtara bụ otu ihe, mana ọnụnọ insulin na-eme ka ọgwụ a ghara ịma mma,
Diabefarm (maka mbadamba 60, ị ga-akwụ ụgwọ ihe dịka 150 rubles). O nwere ntinye uche siri ike nke glyclazide - 80 mg, nke choro ikpocha otu nsogbu dika Glimecomb.
Gliclazide MV (nkezi ọnụahịa maka mbadamba 60 bụ 200 rubles). Ọ nwere ihe mejupụtara dị iche na Glimecomb, ọ nwere naanị 30 mg nke glycoslazide. Ngosipụta maka ojiji bụ otu ihe dị na ọgwụ mbụ.

Glimecomb: ntuziaka maka ojiji, ọnụahịa, nyocha na analogues

Mgbe ụfọdụ ndị ọrịa na-arịa ọrịa shuga ga-ewere ọtụtụ ọgwụ otu oge. Mana enwere ngwaọrụ nke ihe mejupụtara ya na - agwakọta ihe ndị dị mkpa. Ha na-enye gị ohere ịme otu mbadamba. “Glimecomb” bụ ọgwụ nwere ọgwụ ndị dị etu ahụ. Tulee ntuziaka maka ojiji ya n'uju.

Tụnyere ihe analogues

Ọgwụ a nwere ọtụtụ analogues na mejupụtara ma Njirimara. Ka anyị lerukwuo anya n’ihe dọkịta Glimecomb nwere ike ịnọchi.

Gliformin. Ọnụahịa - site na 250 rubles kwa ngwungwu (iberibe 60). Onye na-eme JSC Akrikhin, Russia. Nwere metformin. Ngwongwo nke mbadamba nkume yiri nke a, mana ọ bụghị maka mmadụ niile. Ejiri mee ka ahụ dị arọ.

Diabefarm. Efu - 160 rubles (mbadamba 60). A na - emepụta ụlọ ọrụ "Pharmacor", Russia. O nwere ihe ndi ozo gliclazide (80 mg), ihe ndi ozo nwere ike ime.

Gliclazide. Site na 200 rubles kwa mkpọ (mpempe 60) Onye na-emepụta ihe - Canonfarm, Russia. Nwere obere gliclazide na ihe mejupụtara (30 mg). Na-enyere aka mee ka ịdị arọ ya dị mma. Ihe mgbakwunye ozo bu ego di ala.

Amaril. Mbadamba ndị dị otú ahụ na-efu site na 800 rubles kwa ngwugwu. Ejiri aka Handoc Inc., Korea. Ọ bụkwa ọgwụgwọ ngwakọta maka ọrịa shuga (glimepiride + metformin). Contraindications yikwara. Mbepu dị ọnụ karịa.

Galvus. Ọnụahịa ahụ na-amalite site na 1600 rubles. Onye rụpụtara ya bụ Novartis Pharma, Germany. Ngwakọta ọgwụ (vildagliptin + metformin). Ọ nwere otu mmetụta na mmachibido maka nnabata dị ka Glimecomb. Ọ na-akwụ ụgwọ karịa, mana oge ụfọdụ ọ na - agbanwe ịdị irè karịa ibe ya.

Ke ofụri ofụri, ndị ọrịa mamịrị nwere ahụmịhe na-azaghachi ọgwụ a. A na-achọpụta nziwanye nke ọgwụgwọ ejikọtara ọnụ mgbe ihe abụọ dị n'ọrụ nọ n'otu mbadamba. Mgbe ụfọdụ, ha na-ede na usọbọ ahụ adabaghị. Nsonaazụ ndị dị ụkọ adịkarịghị.

Victor: “Enwere m ọrịa shuga 2. M na-ewere metformin na gliclazide iche. Ọ dịrịghị m mfe ma dịkwa ọnụ. Dọkịta ahụ kpọfere na Glimecomb. E wezụga eziokwu ahụ m na-a oneụ otu mbadamba mmanya kama abụọ, ana m enwe ahụ efe dị mma. Ahụghị m mmetụta ọ bụla, enwere m afọ ojuju na ọgwụ ahụ. "

Valeria: “Nna m dị afọ 63, a chọpụtara afọ ole na ole gara aga. E meelarị ọtụtụ ihe, ihe niile jiri nwayọ kwụsị ime ihe. Dọkịta dụrụ m ọdụ ka m nwalee Glimecobm, mana dọrọ aka ná ntị na m ga-agbaso nri siri ike ma nyochaa ahụike m. Ọ na-ada kemgbe ọnwa atọ ugbu a, ndị na-egosi shuga dị n’usoro, ibu ahụ adịchabeghị ntakịrị. Ọ masịrị nna m. ”

Lovehụnanya: “Ejirila m ọgwụgwọ a ogologo oge. Enwere m mmasị na oke nke ọnụ ala dị ala na ezigbo mma. Shuga adịghị aba ụba, enwere m mmetụta nke ukwuu, enweghị mmetụta ọ bụla na ya. ”

Gregory: “Dọkịta ahụ nyere Glimecomb iwu. Mgbe ọnwa m gachara, m gbanwere Ntụziaka. Emeghị m nke ọma. Nsogbu diges malitere, yana isi ọwụwa na mgbakwunye. Dọkịta kwuru na ọ bụghị mmadụ niile na-eme ya. Ma nke ahụ ekweghị m. ”

Alla: “Ha họpụtara Glimecomb. A gwọchara ya maka izu abụọ, mana a manyere ya ịgbanye ọgwụgwọ ọzọ. Ọkwa shuga agbanwebeghị, na Kama nke ahụ, ọ buliela ntakịrị. Mana maka ụdị ọnụahịa a, ọ bụghị ihe jọgburu onwe ya na ọ gaghị adabara. ”

Glimecomb jikọtara ọgwụ shuga na-arịa ọrịa shuga

Ọrịa shuga na mba bụ otu n'ime ọrịa ise dị n'obodo anyị nwere nkwarụ ma na-anwụ. Ọbụnadị dịka atụmatụ siri ike siri dị, ihe dị ka ndị ọrịa mamịrị na-egbu ihe ruru 230 puku kwa afọ n’arịa ọrịa shuga na mba. Imirikiti n'ime ha enweghị ike ijikwa ọnọdụ ha na-enweghị ọgwụ mara mma.

Ọgwụ ndị kachasị ewu ewu na oge nwalere shuga bụ shuga sitere na otu nke biagunides na sulfonylureas. A na-agụ ha n'ọtụtụ ebe na-adakarị ọgwụ yana ọtụtụ ọmụmụ, a na-eji ha na ọkwa niile nke ụdị shuga 2.

Ejikọtara ọgwụ Glimecomb (n'ụdị mba Glimekomb) na ndabere nke biagunide na nkwadebe sulfonylurea, na-ejikọ ike nke metformin na glycazide, nke na-enye ohere iji glycemia rụọ ọrụ nke ọma.

Ọgwụ Farmacology Glimecomb

Usoro ihe omume nke nkwadebe siri ike nke ihe mgbagwoju anya di iche iche, nke a na - eme ka o kwe omume imetuta nsogbu site na uzo ozo.

Akụkụ mbụ nke ọgwụ ahụ bụ onye nnọchi anya ọgbọ ọhụrụ nke sulfonylureas. Ike nke ọgwụ nwere ike belata ike ịwalite imepụta insulin ọgwụ ụbara site cells-sel nke pancreas.

Site na mkpali nke muscle glycogen synthase, a na-eme ka itinye glucose site na uru ahụ dị mma, nke pụtara na ọ gbanyeghị abụba.

Na - akọwapụta profaịlụ glycemic nke gliclazide n'ime ụbọchị ole na ole, gụnyere ọrịa shuga metabolic latent.

Site na oge nnata nke nri na nri diges na mmalite nke njikọ nke insulin onwe ya na ọgwụ, mkpa obere oge chọrọ karịa na-enweghị ya.

Hyperglycemia, nke na-egosipụta onwe ya mgbe a afterụsịrị carbohydrates, adịghị ize ndụ mgbe ejiri gliclazide gasịrị. Njikọ Platelet, fiblinolytic na ọrụ heparin na-abawanye na ọgwụ.

Tolebawanyewanye nye heparin, nwere ọgwụ na akụrụngwa antioxidant.

Usoro nke metformin, akụkụ nke abụọ nke Glimecomb, bụ nke sitere na mbelata ọkwa shuga n'ihi mmụba nke glycogen wepụtara na imeju.

Na-eme ka uche nke ndị na - anabata ya, ọgwụ a na --ebilata nguzobe sel nke insulin.

Site na igbochi mmepụta glucose na protin na abụba, ọ na-eme ka ọ dị ngwa ngwa na-ebuga ya na anụ ahụ maka ike ọrụ.

N'ime eriri afọ, metformin na-egbochi nnabata nke glucose na mgbidi. Ihe mejupụtara ọbara na-emeziwanye: nchịkọta nke cholesterol zuru oke, triglycerol na LDL (cholesterol "ọjọọ") na-ebelata, ọkwa HDL (cholesterol) dị mma. Metformin anaghị emetụta mkpụrụ ndụ β-maka ọrụ ndị mepụtara insulin ha. N'akụkụ a, usoro a na-ejikwa gliclazide.

Onye na adighi nma Glimecomb

Edere ọgwụ ejikọtara:

Ọrịa mamịrị nwere oria 1,
Na ketoacidosis (ụdị ọrịa mamịrị),
Site na precca mamịrị shuga
Ọrịa nwere oke akụrụngwa gbasara akụrụngwa
Na ọrịa hypoglycemia,
Ọ bụrụ na ọnọdụ dị njọ (ọrịa, akpịrị ịkpọ nkụ, ujo) nwere ike ibute akụrụ ma ọ bụ imeju afọ,
Mgbe ọrịa pathologies tinyere anụ ahụ oxygen na-akpata (nkụchi obi, obi ma ọ bụ akụkụ iku ume),
Ndị nne dị ime na ndị na-enye nwa ara
Site n'iji miconazole mee ihe,
N'ọnọdụ metụtara dochie mbadamba ụrọ na insulin (ọrịa, arụ ọrụ, nnukwu mmerụ ahụ),
Site na nri hypocaloric (ruo 1000 kcal / ụbọchị),
Maka ndị na-a alcoholụbiga mmanya ókè na-egbu egbu.
Ọ bụrụ na ị nwere akụkọ banyere lactic acidosis.
Na hypersensitivity na ihe nke usoro ọgwụ.