Etu esi eji ogwu Mikardis 80? > Ọgwụgwọ na mgbochi

A na-emepụta Mikardis n'ụdị mbadamba: oke, ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha, n'otu akụkụ enwere ihe osise "51N" ma ọ bụ "52N" (40 ma ọ bụ 80 mg, n'otu n'otu), n'akụkụ nke ọzọ - akara nke ụlọ ọrụ (pcs 7. Na blisters, ọ bụla Mpekere 2, 4, 8 ma ọ bụ 14 n'ime igbe kaadi).

Ngwakọta nke mbadamba 1 gụnyere:

Ihe eji arụ ọrụ: telmisartan - 40 ma ọ bụ 80 mg,
Ngwa ntinye aka (40/80 mg nke ọ bụla): magnesium stearate - 4/8 mg, sodium hydroxide - 3.36 / 6.72 mg, meglumine - 12/24 mg, polyvidone (collidone 25) - 12/24 mg, sorbitol - 168.64 / 337.28 mg.

Mpempe mwepụta

Ọgwụ bụ mbadamba ihe na-acha ọcha na-acha uhie uhie nwere ihe osise 51H nke dị n'otu akụkụ na akara ụlọ ọrụ dị na nsọtụ ọzọ.

7 ụdị mbadamba ụrọ nke nwere 40 mg na paịlị; 2 ma ọ bụ 4 na blisters dị na igbe kaadi. Edide 7 dị mbadamba ụrọ dị otú a na-a ofụ ọgwụ dị 80 mg na chara acha, 2, 4 ma ọ bụ 8 na blisters dị otú ahụ na igbe kaadi.

Pharmacodynamics na pharmacokinetics

Mlọ ọgwụ

Telmisartan - ihe na - ahọrọ ihe nnabata angiotensin II. Nwere nnukwu ebe ije dị AT1 ụdị nnabata angiotensin II. Asọmpi na angiotensin II na ndị nnabata kpọmkwem na-enweghị otu mmetụta. Njikọ ahụ na-aga n'ihu.

O gosiputaghi ikpo oku maka ihe ndi ozo nke nabata ya. Na-ebelata ọdịnaya aldosterone n'ọbara, anaghị egbochi plasma renin na ọwa ion n’ime sel.

Bido mmetụta hypotensive A hụrụ n'ime elekere atọ izizi mgbe nchịkwa gasịrị telmisartan. Omume ahụ dịgide otu ụbọchị ma ọ bụ karịa. Nkwupụta akpọrọ ahụ na-etolite otu ọnwa mgbe nchịkwa na-aga n'ihu.

N'ime ndị mmadụ na- ọbara mgbali iketelmisartan na-ebelata systolic na ọbara mgbali ọbara, mana anaghị agbanwe ọnụọgụ nke obi obi.

Ọ naghị akpata ọrịa wepụ ego.

Mlọ ọgwụ

Mgbe a na -ewere ya okwu ọnụ, ọ na-abanye na eriri afọ ngwa ngwa. Bioavailability na-erute 50%. Mgbe awa atọ gachara, plasma ịta ga-akachasị. 99.5% nke ihe arụ ọrụ na-egbochi protein protein. Metabolized site na nzaghachi na acid glucuronic. Metabolites nke ọgwụ ahụ anaghị arụ ọrụ. Iwepu ọkara ndụ dị ihe karịrị awa iri abụọ. A na-ewepụta ya site na ngwara, digesion na mmamiri erughị 2%.

Ihe ngbanwe

Mpempe akwụkwọ Micardis na-egbochi ndị mmadụ iche iche allergies n'ihe ndị dị na ọgwụ ahụ, dị arọ ọrịaimeju ma obu akụrụ, fructose anabataghị ya, n'oge ime na lactation, ụmụaka ndị gbara afọ 18.

Nsonaazụ

Site na usoro ụjọ ahụ: ịda mbaanya ntughari isi ọwụwaike ọgwụgwụ, nchekasị, ehighi ura, ogwe.
Site na usoro iku ume: ọrịa nke akụkụ okuku ume na elu (sinusitis, pharyngitis, ọla kọpa), ụkwara.
Site na sistemụ mgbasa: ekwuputala mbelata nke nrụgide, tachycardia, bradycardiaobi mgbu.
Site na usoro digestive: ọgbụgbọ, afọ ọsịsa, dyspepsiaịba ụba ịta nke enzymes imeju.
Site na usoro mọzụlụ: myalgiaobere azụ mgbu arthralgia.
Site na usoro genitourinary: edema, ọrịa nke usoro genitourinary, hypercreatininemia.
Mmeghachi omume Hypersensitivity: Skin Rash, angioedema, urticaria.
Ihe ngosi ulo oru: anaemia, hyperkalemia.
Ndị ọzọ: erythemaitching dyspnea.

Mikardis, ntuziaka maka ojiji

Dika ntuziaka maka iji Mikardis, a na-ewere ọgwụ ọnụ. Akwadoro maka ndị okenye kedụ 40 mg otu ugboro n'ụbọchị. N'ọtụtụ ndị ọrịa, a chọpụtalarị ọgwụgwọ ahụ mgbe ị na-a aụ ọgwụ 20 mg kwa ụbọchị. Ọ bụrụ na-egobe nrụgide nke ọkwa nke ịchọrọ, ọ pụtaghị ịrị elu ahụ gaa na 80 mg kwa ụbọchị.

Mmetụta kachasị nke ọgwụ ahụ na-enweta izu ise mgbe ịmalite ọgwụgwọ.

N'ime ndị ọrịa nwere ụdị siri ike ọbara mgbali ike enwere ike iji ya 160 mg ọgwụ kwa ụbọchị.

Mmekorita

Telmisartan rụọ ọrụ mmetụta hypotensive ụzọ ndị ọzọ nke iwetulata nrụgide.

Mgbe ejikọtara ọnụ telmisartan na digoxin oge ekwesiri itinye uche n'ihe digoxin n’ime ọbara, dịka o nwere ike ibili.

Mgbe ị na-a drugsụ ọgwụ ọjọọ lithium na Ihe mgbochi ACE enwere ike ịhụgo mgbakwunye na ọdịnaya nwa oge lithium n'ọbara, nke ihe ndia na aru aru.

Ọgwụgwọ ọgwụ mgbochi-anaghị egbochi steroidal ya na Mikardis na ndi oria akpukpo aru nwere ike ibute mmepe nke nnukwu akwara gbasara ha.

Ntụziaka pụrụ iche

N'ihi na ndị ọrịa gwụrụ (mgbochi nnu, ọgwụgwọ diuretics, afọ ọsịsa, vomiting) mbelata nke ọgwụ Mikardis dị mkpa.

Jiri nlezianya na-ahọpụta ndị mmadụ stenosis ha abuo gbasara akwara, mitral valve stenosis ma obu cardioyopathy aortic hypertrophic ihe mgbochi, nnukwu akụrụ, ọrịa ịba ọcha n'anya ma ọ bụ nkụchi obi, ọrịa nke ngwara nri.

Amachibidoro iji ya mgbe isi izizi na fructose anabataghị ya.

Site na ịtụrụ ime, ị ga-ebu ụzọ chọta onye ọzọ maka Mikardis ọgwụ antihypertensive.

Jiri mkpachapụ anya mgbe ị na-anya ụgbọala.

Na concomitant iji ọgwụ ọjọọ lithium A na - egosiputa nlezianya nke ọdịnaya lithium n'ime ọbara, ebe ọ bụ na enwere ike ịbawanye nwa oge na ọkwa ya.

Mikardis Ahịa

Na Russia, ngwugwu nke 80 mg Nke 28 ga-efu site na 830 ruo 980 rubles. Na Ukraine, ọnụahịa Mikardis n'otu mbipụta ahụ na-eru nso hryvnias 411.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Mikardis. Na-enye nzaghachi sitere na ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara iji Mikardis na-eme ha. Arịrịọ dị ukwuu bụ ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Mikardis analogues n'ihu nke usoro analogues nke dịnụ. Jiri maka ọgwụgwọ ọbara mgbali elu na mbelata mgbali ọbara n’etiti ndị okenye, ụmụaka, yana n’oge afọ ime na n’ara. Ngwakọta ọgwụ ahụ.

Mikardis - ọgwụ antihypertensive.

Telmisartan (ihe na-arụ ọrụ nke Mikardis ọgwụ) bụ onye na - emegide ihe nnabata nke angiotensin nke 2. Ọ nwere oke mmekọrịta maka AT1 receptor subtype nke angiotensin 2, site na nke a ga - amata site na angiotensin 2. Telmisartan chụpụrụ angiotensin 2 site na onye nnabata, na - enweghị ọrụ nke agonist n'ihe metụtara nnabata a. Ọ na-etolite njikọ naanị na AT1 receptor subtype nke angiotensin 2. Ijikọ ahụ na-aga n'ihu. Telmisartan enweghị mmekọrịta maka ndị na-anabata ndị ọzọ (gụnyere ndị na-anabata AT2) na ndị na-anabata angiotensin na-erughị ọmụmụ. Ọdịghị uru ọrụ ndị nnata a bara, yana nsonaazụ nke ike ha nwere ike ọfụma ya na angiotensin 2, amụchaghị nke na-abawanye na nhọpụta nke telmisartan. Ọ na -ebelata mkpụkọ aldosterone n'ọbara, anaghị egbochi mmiri renin na plasma ọbara ma ọ dịghị egbochi ụzọ ion. Ọ naghị egbochi ACE (kininase 2), enzyme nke na-ebibikwa bradykinin, yabụ, atụghị anya na nsonaazụ ndị ọ bụla na-akpata bradykinin.

Mikardis na nha nke 80 mg kpamkpam egbochi hypertensive mmetụta nke angiotensin 2. A na-ahụ mmalite mmalite nke hypotensive n'ime elekere 3 mgbe nchịkwa nke telmisartan mbụ. Mmetụta ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo ihe dị ka awa 48. Mmetụta mmetụta hypotensive na-amalitekarị mgbe izu 4-8 nke ị na-eji eme ya mgbe niile.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata systolic na ọbara mgbali, na-enweghị emetụta mmetụ obi.

N'ihe banyere ịkagbu Mikardis na mberede, AD ji nwayọ laghachi ọkwa mbụ ya na enweghị mmepe nke ọrịa ndọrọ ego.

Hydrochlorothiazide (ihe na-arụ ọrụ nke ọgwụ Mikardis Plus) bụ thiazide diuretic. Thiazide diuretics emetụta reabsorption nke electrolytes n'ime akụrụ renal, na-abawanye mkpachapụ nke sodium na chlorides (ihe dị ka nha). Mmetụta diuretic nke hydrochlorothiazide na-eduga ná mbelata nke bcc, mmụba na ọrụ plasma renin, mmụba na nzuzo nke aldosterone ma na-esokwa mmụba na potassium na bicarbonates, na n'ihi ya, mbelata nke potassium na plasma ọbara. N'iji telmisartan na-eme n'otu oge, enwere echiche nke ịkwụsị potassium na-akpata site na diuretics ndị a, a ga-eche na ọ bụ ihe mgbochi RAAS.

Mgbe iwere hydrochlorothiazide, diuresis na-abawanye mgbe oge awa abụọ gasịrị, a na-ahụkwa mmetụta kachasị mgbe ọ gachara awa 4. Mmetụta diuretic nke ọgwụ ahụ na-adịgide ruo ihe dịka awa 6-12.

Ogologo oge iji hydrochlorothiazide na-ebelata ihe egwu nke ọrịa obi na onwu site na ha.

Mmetụta antihypertensive kachasị nke ọgwụ Mikardis Plus na-arụkarị izu 4-8 mgbe mmalite ọgwụgwọ.

Ngwakọta

Ndị na-ahụ maka Telmisartan + (Mikardis).

Telmisartan + hydrochlorothiazide + excipients (Mikardis Plus).

Mlọ ọgwụ

Mgbe a na - eduzi ya, a na - etinye telmisartan ngwa ngwa site na nri diges. Bioavailability bụ 50%. Mgbe ewere nri n'otu oge, mbelata nke ụkpụrụ AUC sitere na 6% (mgbe ejiri ya na 40 mg) ruo 19% (mgbe ejiri ya na 160 mg). Mgbe awa atọ gachara, ochichi ọbara nke plasma dị n'ọbara na agbanyeghị oge ị ga-eri nri. A na-agagharị ya site na conjugation na glucuronic acid. Metabolites anaghị arụ ọrụ ọgwụ. Ọ nọ n’eriri na - agbanweghi agbanwe, akwara ewepụrụ ya - na - erughi 2% nke ọgwụ a .ụrụ.

Enwere ọdịiche na mkpokọta dị n'etiti ụmụ nwoke na ụmụ nwanyị. N'ime ụmụ nwanyị, Cmax na AUC dị ihe dịka ugboro atọ na oge abụọ karịa nke ụmụ nwoke (na-enweghị nnukwu mmetụta na arụmọrụ).

Pharmlọ ọgwụ ọgwụ nke telmisartan na ndị ọrịa merela agadi adịghị iche na pharmacokinetics na-arịa ọrịa na-eto eto. Dose ukpụhọde adịghị.

Achọghị mgbanwe mgbanwe nke oge a na ndị ọrịa nwere ọrịa akụrụ, gụnyere ndị ọrịa n'ọrịa metụtara akwara ụkwụ. Achọpụghị Telmisartan.

N'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ nke obere ruo ogo dị ala (klas A na B n'ọtụtụ -mụaka), kwa ụbọchị ọgwụ ahụ agaghị agafe 40 mg.

Ihe ngosiputa nke pharmacokinetics nke telmisartan na umuaka na umuaka noo n’agbata afọ 6 ruo 18 ka ha gbasachara telmisartan na 1 mg / n'arọ ma ọ bụ 2 mg / n'arọ maka izu anọ na-adịkarị na data enwetara na ọgwụgwọ nke ndị toro eto ma gosipụta na abụghị linearity nke pharmacokinetics. telmisartan, ọkachasị na-akwanyere Cmax.

Mgbe nchịkwa ọnụ gasịrị, a na-enweta Mikardis Plus Cmax hydrochlorothiazide n'ime awa 1-3. Ihe na-emetụta bioavailability zuru oke site na mmiri ọgwụ hydrochlorothiazide ma ihe dị ka 60%. Ọ na-ejikọ protein protein plasma site na 64%. Adịghị metabolized n'ime ahụ mmadụ ma wepụta ya na mmamịrị na-agbanweghi agbanwe. A na-ewepụ ihe dị ka 60% nke ọgwụ a na-etinye ọnụ n'ime awa 48.

Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. N'ime ụmụ nwanyị, enwere ebumnuche nke mmụba dị ukwuu na clinical nke mmiri hydrochlorothiazide.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, ọnụego mkpochapu hydrochlorothiazide belatara.

Ihe na-egosi

ọbara mgbali ọbara (mbelata mgbali),
mbelata na ọrịa obi na ọrịa na ndị ọrịa afọ 55 gbagoro ma nwee nnukwu ọrịa nke ọrịa obi.

Dị Mwepụta

Mbadamba 40 mg na 80 mg.

Mbadamba 40 mg + 12.5 mg na 80 mg + 12.5 mg (Mikardis Plus).

Ntụziaka maka ojiji na usoro onunu ogwu

Edere ọgwụ a n'ọnụ, n'agbanyeghị nri ị ga-eri.

Site n'ọbara mgbali elu, usoro ọgwụgwọ akwadoro nke Mikardis bụ mbadamba 1 (40 mg) otu ugboro n'ụbọchị. N'ọnọdụ ebe enweghi ike nweta ọgwụgwọ ọgwụgwọ, enwere ike ịba ụba nke ọgwụ ahụ ka ọ bụrụ 80 mg otu ugboro kwa ụbọchị. Mgbe ị na-ekpebi ma ịbawanye ọgwụ ahụ, ekwesịrị iburu n'uche na mmetụta antihypertensive kachasị na-arụkarị n'ime izu 4-8 mgbe mmalite nke ọgwụgwọ.

Iji belata ọrịa obi na ọrịa, usoro a tụrụ aro ya bụ mbadamba 1 (80 mg) otu ugboro n'ụbọchị. N’oge mmalite ọgwụgwọ, enwere ike ịchọ mgbazi ọbara mgbali elu ọzọ.

Ọria achọrọ ndị ọrịa nwere akụrụngwa akụrụngwa (ya na ndị nke metụtara ịwa ahụ).

N'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ nke obere ruo ogo dị ala (klas A na B n'ọtụtụ -mụaka), kwa ụbọchị ọgwụ ahụ agaghị agafe 40 mg.

Usoro usoro onunu ogwu n’ebe ndi agadi no achoghi mgbanwe.

Ekwesịrị iji ọnụ Mikardis Plus ugboro 1 kwa ụbọchị, n'agbanyeghị nri.

Enwere ike inye Mikardis Plus 40 / 12.5 mg maka ndị ọrịa ebe ọgwụ Mikardis dị na ọgwụ nke 40 mg ma ọ bụ hydrochlorothiazide adịghị ebute nchịkwa zuru oke nke ọbara mgbali.

Enwere ike inye Mikardis Plus 80 / 12.5 mg nye ndị ọrịa ebe ọgwụ Mikardis dị na ọgwụ nke 80 mg ma ọ bụ Mikardis Plus 40 / 12.5 mg anaghị ebute nchịkwa zuru oke nke ọbara mgbali.

N'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba, ọnụọgụ kachasị kwa ụbọchị nke telmisartan bụ 160 mg kwa ụbọchị. Ogo ọgwụ a dị irè ma na-anabata nke ọma.

Mmetụta akụkụ

ọrịa mgbakasị ume (gụnyere oyi baa na ure),
mkpụkpu ume
arrhythmias
tachycardia
bradycardia
mbelata ọbara mgbali elu (gụnyere hyporatet orthostatic),
ịkụda mmụọ
paresthesia
nsogbu ịrahụ ụra
ehighi ura
anya ntughari
nchegbu
ịda mba
mgbakasị ahụ
isi ọwụwa
afọ ọsịsa, afọ ntachi,
akọrọ mucosa onu,
flatulence
mgbu afọ
vomiting
eriri afọ
nri riri
anorexia
hyperglycemia
hypercholesterolemia,
ọria aru
ọrụ imeju na-arụ ọrụ,
jaundice (hepatocellular ma ọ bụ cholestatic),
dyspepsia
amata aja aja
azu mgbu
akwara mgbu
myalgia
arthralgia,
akwara gbasara ahụ,
ọrịa ogbu na nkwonkwo,
Mgbaàmà tendonitis
obi mgbu
ụkọ iron, ọrịa anaemia, hemolytic anaemia, thrombocytopenia, eosinophilia, leukopenia, agranulocytosis, thrombocytopenia,
gbasara akụrụngwa, gụnyere nnukwu gbasara akụrụ,
intersitial nephritis,
glucosuria
mmebi anya
oge adịghị anya
mmechi akpukpo aru
enweghi ike
sepsis, gụnyere ikpe na-egbu egbu,
ọrịa elu akụkụ akụkụ okuku ume na akwara (bronchitis, pharyngitis, sinusitis),
Ọrịa urinary na-efe efe (gụnyere cystitis),
mbufụt nke gland,
ụba ọrụ nke enzymes imeju,
ụba ọrụ nke CPK,
ịba ụba nke uric acid n'ime ọbara,
hypertriglyceridemia,
hypokalemia, hyperkalemia,
hyponatremia,
hyperuricemia
hypoglycemia (n'ime ndị ọrịa na-arịa ọrịa shuga mellitus),
enwere ikike nnabata glucose,
wedata na haemoglobin n'ime ọbara,
ọrịa anakedeede (gụnyere ọrịa na-egbu egbu),
erythema
akpụkpọ anụ?
ihe nwu
mmeghachi omume anaphylactic,
amu amu
Ọgwụ ọgwụ
necrolysis na-egbu egbu
lupus-dị ka mmeghachi omume
iwe ma ọ bụ njọ nke ihe mgbaàmà nke lupus erythematosus,
necrotic vasculitis,
systemic vasculitis
mmeghachi omume nzibe,
nlọghachi nke system lupus erythematosus,
vasculitis
oria-di ka oria
ahụ ọkụ
adịghị ike.

Ihe ngbanwe

ọrịa biliary ọnya na-egbochi,
oke ọrụ imeju (Child-Pugh klas C),
nnukwu nsogbu gbasara akụrụ (CC na-erughị 30 ml / min),
hypokalemia refractory, hypercalcemia,
n'otu oge iji aliskiren n'ime ndị ọrịa nwere ọrịa mellitus na ọdịda akụrụ (GFR erughị 60 ml / min / 1.73 m2),
hereditary fructose ekweghị ibe (ọgwụ nwere sorbitol),
ụkọ lactase, nnagide nri nke lactose, ọrịa glucose-galactose malabsorption,
gbara afọ 18 (nchekwa na arụmọrụ edozighi),
tụụrụ ime
lactation (lactation),
hypersensitivityị ma ọ bụ ihe enyemaka nke ọgwụ ma ọ bụ ihe ndị ọzọ na-eme ka sulfonamide.

Stenosis abụọ akụrụngwa akwara ma ọ bụ stenosis nke otu akụrụ,
ọrụ imeju na-arụ ọrụ ma ọ bụ ọrịa imeju na-aga n'ihu (klas A na B n'ọtụtụ nwatakịrị).
mbelata na BCC n'ihi usoro ọgwụgwọ ụkwara ọsịda, mmachi na ị ofụ nnu, afọ ọsịsa ma ọ bụ ọgbụgbọ,
hyperkalemia
Ọnọdụ mgbe akụrụgharị akụrụ (enweghị ahụmịhe iji ya),
okpukpo obi nke na-ala ala 3-4 FC dị ka nhazi nke New York Heart Association,
stenosis nke aortic na valvụ valve,
mmiri ọgwụ mgbochi sitenaosis hypertrophic,
ike obara nke obara,
ọrịa shuga mellitus
isi izizi,
gout
glaucoma nke mechiri emechi (n'ihi ọnụnọ hydrochlorothiazide na ihe mejupụtara).

Ime na lactation

Ihe contraindicated ka ojiji nke Mikardis na Mikardis Plus n'oge ime.

Ekwesighi iji ọgwụ angiotensin 2 antagonists na ọkara nke 1 nke afọ ime, ekwenyeghị ọgwụ ndị a n'oge ime. Mgbe ime dị ime, a ga-akwụsị ọgwụ ozugbo. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịkọwa usoro ọgwụgwọ ọzọ (klas ndị ọzọ nke ọgwụ nje na-akwadoro iji mee n'oge afọ ime).

A na - emegidekwa ọgwụ maka angiotensin 2 antagonists na ọkara nke abụọ na nke atọ nke afọ ime. N'ime ọmụmụ ọmụmụ telmisartan, achọpụtaghị mmetụta teratogenic, mana etinyere fetotoxicity. A maara na mmetụta nke angiotensin 2 antagonist antagonists na oge nke abụọ na nke atọ nke afọ ime na-akpata fetotoxicity na mmadụ (belatara ọrụ gbasara aha, oligohydramnios, igbu oge ossification nke okpokoro isi), yana nsonye obi nke akwara (ọdịda akụrụ, ọdịda, hypotension, hyperkalemia). Ekwesịrị inye ndị ọrịa na-eme atụmatụ ịtụrụ ime. Ọ bụrụ na a na - eme ọgwụgwọ na angiotensin 2 antagonist antagonists na ọnwa nke abụọ nke afọ ime, a na - atụ aro ultrasound nke akụrụ na ọkpụkpụ isi nke nwa ebu n’afọ.

Ndi amuru ohuru ndi nne ha nwetara anakpo angiotensin 2 kwesiri ileba anya n’ariri arusi.

Ahụmahụ hydrochlorothiazide n'oge afọ ime, ọkachasị n'oge ọnwa atọ. Hydrochlorothiazide na-agafe ihe mgbochi placental. Nyere usoro ogwu nke aru nke hydrochlorothiazide, ekwenyere na ojiji ya n’ime oge nke ato na nke ato n’abia nwere ike imebi udiri ekpomoku ma mee mgbanwe n’ime ẹmbrayo na nwa n’afọ, dika jaundice, electrolyte improlance, na thrombocytopenia. Ekwesighi iji Hydrochlorothiazide maka edema nke ụmụ nwanyị dị ime, maka ụmụ nwanyị dị ime nwere ọbara mgbali elu, ma ọ bụ n'oge preeclampsia. enwere ọghọm dị na olu plasma na mbelata nke ọgbụgba placental, enweghị mmetụta dị mma n'ọnọdụ ọnọdụ ndị a.

Ekwesighi iji Hydrochlorothiazide na-agwọ ọbara mgbali dị mkpa n'ime ụmụ nwanyị dị ime, belụsọ n'ọnọdụ ndị ahụ dị ụkọ ebe enweghị ike iji ọgwụgwọ ndị ọzọ.

Usoro ọgwụgwọ na ọgwụ Mikardis na Mikardis Plus bụ contraindicated n’oge a na-enye nwa ara.

N'ime nyocha anụmanụ, a hụghị nsonaazụ nke telmisartan na hydrochlorothiazide na ọmụmụ.

Emebeghị nnyocha banyere mmetụta na ọmụmụ ụmụ mmadụ.

Jiri na umuaka

A na - egbochi ọgwụ ndị Mikardis na Mikardis Plus maka ụmụaka na ndị nọ n'afọ iri na asatọ, n'ihi na Enweghị data dị mma na nchekwa dị na ụdị ndị ọrịa a.

Jiri ndị ọrịa agadi

Achọghị mgbanwe n’usoro usoro onunu ogwu n’ebe ndị ọrịa nọ.

Ntụziaka pụrụ iche

Ọnọdụ na-eme ka Ọrụ RAAS dịkwuo elu

Somefọdụ ndị ọrịa, n'ihi nnabata nke ọrụ RAAS, ọkachasị na nchịkwa nke otu ọgwụ ọgwụ na-arụ ọrụ na sistemụ a, arụ ọrụ akụrụngwa (gụnyere nnukwu akụrụ gbasara akwara). Ya mere, usoro ọgwụgwọ a na-ejikọ ya na mgbochi abụọ yiri ya nke RAAS (dịka ọmụmaatụ, na mgbakwunye nke ACE inhibitor ma ọ bụ onye na-egbochi renin inhibitor, aliskiren, na angiotensin 2 receptor antagonist blockers), kwesịrị ịrụ ọrụ na-akwụghị aka n'otu n'otu na iji nlezianya na-arụ ọrụ na-akwụghachi ụgwọ oge niile serum creatinine).

Ojiji nke thiazide diuretics n'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa nwere ike ibute azotemia. A na-atụ aro maka oge ọrụ nke akụrụngwa.

N'ime ndị ọrịa nwere akwara mkpụrụ ndụ akwara stenosis ma ọ bụ stenosis akwara nke naanị akụrụ na-arụ ọrụ, n'iji ọgwụ na-emetụta RAAS, ihe ize ndụ nke ịmalite ịrịa hypotension akwara na ọdịda akụrụ na-abawanye.

Ọrụ imeju na-arụ ọrụ

N'ime ndị ọrịa nwere ọrụ imeju na-arịa ọrịa ma ọ bụ ọrịa imeju na-aga n'ihu, ekwesịrị iji MikardisPlus jiri nlezianya mee ihe, ebe ọ bụ na obere mgbanwe na mmiri-electrolyte nwere ike inye aka na mmepe nke hepatic coma.

Mmetụta metabolism na ọrụ nke glands endocrine

N'ime ndị ọrịa nwere ọrịa shuga, mgbanwe mgbanwe nke insulin ma ọ bụ ndị na-ahụ maka hypoglycemic maka nchịkwa ọnụ. N'oge ọgwụgwọ turezide diuretics, ọrịa shuga mellitus latent nwere ike igosipụta.

N'ụfọdụ, ojiji nke thiazide diuretics nwere ike ịmalite hyperuricemia na iwe nke usoro gout.

N'ime ndị ọrịa nwere ọrịa mellitus na ọrịa obi, dịka ọmụmaatụ, n'ime ndị ọrịa nwere ọrịa mellitus na ọrịa obi, ojiji nke ọgwụ ndị na-ebelata ọbara mgbali, dịka angiotensin 2 antagonists ma ọ bụ ndị na-egbochi ACE, nwere ike ịbawanye n'ihe ize ndụ nke infarction myocardial infarction na mberede obi. ọnwụ nke akwara. N'ime ndị ọrịa nwere ọrịa shuga, ọrịa obi na-arịa ọrịa obi nwere ike ịbụ asymptomatic ya mere ya agaghị enwe ike ịchọpụta ya. Tupu ịmalite iji ọgwụ Mikardis na Mikardis Plus maka nchọpụta na ọgwụgwọ nke ọrịa obi, a ga-eme ọmụmụ nchọpụta kwesịrị ekwesị, gụnyere nwalee ya na mmega ahụ.

Nnukwu myopia na akụkụ ihu nke mechiri glaucoma

Hydrochlorothiazide, ịbụ ihe na-esite na sulfonamide, nwere ike ime mmeghachi omume uche n'ụdị myopia na-adịghị ala ala na nnukwu mmechi glaucoma. Ihe mgbaàmà nke nsogbu ndị a bụ mbelata nke a na-atụghị anya ya na nhụjuanya anya ma ọ bụ ihe mgbu anya, nke na-emekarị n'ime awa ole na ole ruo ọtụtụ izu mgbe ịmalite ọgwụ. Ọ bụrụ na agwọtaghị ya, glaucoma nwere nnukwu nsogbu, nwere ike bute ọnwụ. Isi ọgwụgwọ bụ ịkwụsị hydrochlorothiazide ngwa ngwa o kwere mee. Ekwesịrị iburu n'uche na ọ bụrụ na nrụgide intraocular na-anọgide na-achịkwa, enwere ike ịchọrọ ọgwụgwọ ma ọ bụ ọgwụgwọ ịwa ahụ ngwa ngwa. Ihe ndị dị egwu maka mmepe nke glaucoma nwere nnukwu ọrịa mejupụtara gụnyere akụkọ banyere allergies na sulfonamides ma ọ bụ penisilini.

Mmebi nke mmiri-electrolyte itule

Mgbe ị na-eji ọgwụ Mikardis Plus, dị ka ọ dị n'ihe banyere ọgwụgwọ ọrịa diuretic, nlele oge niile nke ọdịnaya electrolytes n'ọbara ọbara.

Thiazide diuretics, incl. hydrochlorothiazide, nwere ike ịkpata ọgba aghara na mmiri-electrolyte nguzo ya na steeti acid-base (hypokalemia, hyponatremia na hypochloremic alkalosis). Ihe mgbaàmà nke ọrịa ndị a gụnyere mucosa a na-akpọ ede, akpịrị ịkpọ nkụ, adịghị ike n'ozuzu, ụra, ụjọ, myalgia ma ọ bụ ntigbu akwara nke nwa ehi (crumpi), adịghị ike anụ ahụ, mbelata ọbara mgbali elu, oliguria, tachycardia, na eriri afọ dị otú ahụ. nsogbu nke eriri afọ dịka ọgbụgbọ ma ọ bụ ọgbụgbọ.

Mgbe ejiri thiazide diuretics, hypokalemia nwere ike ịmalite, mana telmisartan ejiri otu oge ahụ nwere ike iwelie ọdịnaya potassium na ọbara. Ihe isi ike nke hypokalemia na-abawanye na ndị ọrịa nwere ọrịa cirrhosis, na ịba ụba diuresis, na nri nnu na-enweghị, yana n'ihe banyere n'otu oge iji gluco na mineralocorticosteroids ma ọ bụ corticotropin. Telmisartan, nke bụ akụkụ nke nkwadebe Mikardis na Mikardis Plus, na ntụle, nwere ike ibute hyperkalemia n'ihi antagonism na angiotensin 2 receiptors (subtype AT1). Agbanyeghị na enwebeghị akuko hyperkalemia dị n'ụlọ ọgwụ site na iji Mikardis Plus, ihe ndị nwere ike ibute ya na mmepe gụnyere akụrụ gbasara akwara na / ma ọ bụ nkụchi obi na ọrịa shuga mellitus.

Enweghị ihe akaebe na ọgwụ Mikardis Plus nwere ike belata ma ọ bụ gbochie hyponatremia nke diuretics kpatara. Hypochloremia na-adịkarị obere ma ọ chọghị ọgwụgwọ.

Ọrịa akụrụngwa Thiazide nwere ike belata akụrụ kals nke calcium na ihe kpatara ya (enweghị enweghị mgbakasị ahụ na calcium metabolism), obere oge na -ewelata kalsum ahụ. Ọrịa hypercalcemia siri ike karị nwere ike ịbụ akara nke hyperparathyroidism latent. Tupu ị nyochaa ọrụ nke glands parathyroid, ekwesịrị ịkwụsị thiazide diuretics.

Egosipụtala ya na mkpụrụ osisi thiazide na-eme ka akịrịkọ magnesium na-abawanye site na akụrụ, nke nwere ike ibute hypomagnesemia.

N'ime ndị ọrịa nwere ọrịa obi, iji ọgwụ ọ bụla antihypertensive, n'ihe banyere mbelata ọbara mgbali elu, nwere ike ibute infarction ma ọ bụ ọnya afọ.

Enwere akụkọ banyere mmepe nke systemic lupus erythematosus na thiazide diuretics.

Enwere ike iji Mikardis na Mikardis Plus, ma ọ bụrụ na ọ dị mkpa, na ndị ọzọ na - eme ihe ọnụ.

Dysfunction of the imeju na mgbe a na-ahọpụta telmisartan n'ọtụtụ ikpe ka a hụrụ n'etiti ndị bi na Japan.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Nnyocha ọmụmụ pụrụ iche iji chọpụta mmetụta ọgwụ ọgwụ Mikardis Plus nwere ike ịkwọ ụgbọala na ịrụ ọrụ na-achọkarị mmụba ọ bụla. Agbanyeghị, mgbe ị na-anya ụgbọala na itinye aka n'ihe ndị nwere ike ibute nsogbu ahụ, ekwesiri ịbanye na iwe na ujo ụra, nke chọrọ ịkpachara anya.

Mkparịta ụka ọgwụ ọjọọ

N'iji oge nke telmisartan na:

ndị ọzọ na - arụ ọrụ antihypertensive nwere ike ịkwalite mmetụta antihypertensive. N’otu nnyocha, na iji telmisartan na ramipril jikọtara ọnụ, a hụrụ mmụba nke okpukpu abụọ na AUC0-24 na Cmax nke ramipril na ramipril. Egosipụtaghi mkpa ihe omumu a diri. Nchoputa nke ihe ojoo na-eduga na nkwụsị ọgwụgwọ na nyocha banyere ihe ọjọọ dị njọ enwetara n’oge nnwale ahụike kpughere na ụkwara na angioedema yikarịrị na ramipril, ebe hypotension na-ahụkarị na telmisartan. Ọnọdụ nke hyperkalemia, akwara odida, akwara hypotension na syncope ka a hụrụ nke ukwuu oge nke sistemu na telmisartan na ramipril,
Nkwadebe lithium chọpụtara mmụba na -agaghari iwebata lithium n'ọbara, tinyere nsonaazụ yana ojiji nke ndị na - egbochi ACE. N'ọnọdụ ndị a na-adịghị ahụkebe, a kọọrọ mgbanwe ndị dị otú ahụ na nchịkwa nke angiotensin 2 antagonists, na telmisartan. N'iji oge nke lithium eji eme ihe na angiotensin 2 antagonist antagonist, a na-atụ aro iji chọpụta ọdịnaya lithium dị n'ọbara,
ọgwụ mgbochi anaghị agwọ ọrịa (NSAIDs), gụnyere acetylsalicylic acid na usoro onyonyo ndị a na-eji ọgwụ mgbochi mkpali, ndị na-egbochi COX-2 na ndị na-adịghị ahọrọ NSAIDs, nwere ike ibute nnukwu ọrịa gbasara akụrụngwa na ndị ọrịa nwere BCC belatara. Ọgwụ ndị na-emetụta RAAS nwere ike inwe mmetụta synergistic. N'ime ndị ọrịa na-anata NSAIDs na telmisartan, BCC ga-akwụghachi ụgwọ na mbido ọgwụgwọ ya ma a ga-eme nyocha banyere ọrụ akụrụ. Mbelata na nsonaazụ nke ndị na - egbochi ọgwụ mgbochi, dịka telmisartan, site na mgbochi nke vasodilating mmetụta nke prostaglandins ka a hụrụ yana usoro ejikọtara ya na NSAIDs. Site n'iji telmisartan na ibuprofen ma ọ bụ paracetamol, na-enweghị mmetụta pụtara ìhè n'ụlọ ọgwụ,
digoxin, warfarin, hydrochlorothiazide, glibenclamide, simvastatin na amlodipine egosighi mmekọrịta dị ịrịba ama na ụlọ ọgwụ. Mmụba dị ịrịba ama na nkezi nke digoxin na plasma ọbara site na nkezi 20% (n'otu oge, pasent 39%). Site na nlekọta nke telmisartan na digoxin, ọ bụ ihe amamihe dị na ya ikpebi oge ịhapụ digoxin n'ọbara.

Iji nke imekotaotuugbo iji:

ethanol (mmanya), barbiturates ma ọ bụ opioid analgesics, enwere ihe ize ndụ nke ịmalite hyperension orthostatic,
ọgwụ hypoglycemic maka nchịkwa ọnụ na insulin nwere ike ịchọ mmegharị nke ndị hypoglycemic ndị na-ahụ maka nchịkwa ọnụ na insulin,
metformin nwere ihe ize ndụ nke lactic acidosis,
kolestiraminom na kolestipolom - na ọnụnọ nke mgbanwe mgbanwe anionic na-amalite ịnwe mmiri hydrochlorothiazide,
Cardiac glycosides na-abawanye ihe ize ndụ nke ịmalite hypokalemia ma ọ bụ hypomagnesemia nke thiazide diuretics, mmepe nke arrhythmias nke kpatara cardiac glycosides,
pressor amines (dịka ọmụmaatụ norepinephrine) nwere ike ibelata nsogbu nke amor pressor,
ndị na - anaghị eme ka akwara dị jụụ (dịka tubocurarine chloride) hydrochlorothiazide nwere ike ịkwalite nsonaazụ na - abụghị nke depolarizing muscle muscle,
ndị na-emegide ọgwụ na-eme ka ike ịbawanye ụba nke uric acid n'ime ọbara ọbara yabụ ya mere enwere ike ịchọ mgbanwe na dose nke uricosuric. Ojiji nke thiazide diuretics na-abawanye ugboro nke mmepe nke mmeghachi omume hypersensitivity na allopurinol,
nhazi nke calcium - thiazide diuretics nwere ike ịbawanye calcium serum n'ihi mbelata akwara ya site na akụrụ. Ọ bụrụ n’ịchọrọ iji calcium eme ihe, ị kwesịrị ị na-enyocha ihe ndị dị na calcium n’ọbara, ma ọ bụrụ na ọ dị mkpa, gbanwee dose nke nkwado calcium.
beta-igbochi na diazoxide thiazide diuretics nwere ike ịkwalite hyperglycemia nke beta-blockers na diazoxide kpatara,
m-anticholinergics (dịka ọmụmaatụ, atropine, biperidine) - mbelata nke eriri afọ, mmụba na bioavailability nke diuretics thiazide,
amureadine thiazide diuretics nwere ike ịbawanye n'ihe ọghọm nke mmetụta amantadine kpatara,
ndị na - eme cytotoxic (dịka ọmụmaatụ, cyclophosphamide, methotrexate) - mbelata nke mkpịsị akụrụngwa nke ndị ọrụ cytotoxic na mmụba na mmetụta myelosuppressive ha,
NSAIDs - jikọtara ya na thiazide diuretics nwere ike ibute mbelata mmetụta di egwu na antihypertensive,
ọgwụ ndị na - eduga na mkpochapụ nke potassium na hypokalemia (dịka ọmụmaatụ, diuretics na - ewepu potassium, laxatives, gluco- na mineralocorticosteroids, corticotropin, amphotericin B, carbenoxolone, benzylpenicillin, ihe dị iche iche nke acetylsalicylic acid) - mụbara mmetụta hypokalemic. Hypokalemia nke hydrochlorothiazide na-amalite na-eme ka ọ bụrụ mkpụrụ sitere na mkpụrụ ọgwụ potassium nke telmisartan,
mmepe nke hyperkalemia ga - ekwe omume site na ọgwụ ndị na - eme ka potassium dị ukwuu, ịkwado potassium, ụzọ ndị ọzọ nke nwere ike ịbawanye ọdịnaya potassium n'ụba (dịka ọmụmaatụ, heparin) ma ọ bụ dochie sodium na sodium chloride na potassium salts. A na-atụ aro ka ịlele potassium na oge plasma ọbara n'ọbara ebe a na-eji ọgwụ Mikardis Plus eme ihe n'otu oge yana ọgwụ ndị nwere ike ibute hypokalemia, yana ọgwụ nwere ike ịba ụba potassium.

Analogues nke ọgwụ Mikardis

Anakpụrụ nke analogues nke na-arụ ọrụ:

Analogs na otu ọgwụ ọgwụ (angiotensin 2 antagonist antagonist):

Angiakand
Aprovel
Atacand
Ngọngọ
Vasotens,
Valz
Aha ya bụ Valsartan
Valsafors,
Valsacor
Hyposart,
Diovan
Zisakar
Ibertan
Irbesartan
Izar
Candecor
Candesartan
Cardosal
Cardosten
Cardostin
Karzartan
Cozaar
Xarten
Lakea
Lozap,
Lozarel
Losartan
Lorista
Losacor
Lotor
Mikardis Gụnyere,
Naviten
Nortian
Olimestra
Ordiss
Ochichi
Presartan
Nkọwapụta
Sartavel
Tanidol
Tantordio
Tareg
Gụrụ
Itinye
Telzap
Telmisartan
Telmista
Telsartan
Firmast
Edarby.

Nọmba ndebanye: P N015387 / 01

Aha ahia ogwu: Mikardis ®

International Nonproprietary Aha (INN): telmisartan

Mpempe usoro onunu ogwu: mbadamba

Ngwakọta: 1 mbadamba ihe nwere:
Ihe eji arụ ọrụ: - Telmisartan 40 mg ma ọ bụ 80 mg,
Ndị pụrụ iche: - sodium hydroxide 3.36 mg / 6.72 mg, polyvidone (Kollidon 25) 12 mg / 24 mg, meglumine 12 mg / 24 mg, sorbitol 168.64 mg / 337.28 mg, magnesium stearate 4 mg / 8 mg

Nkọwa
Mbadamba 40 mg
Mbadamba ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke dị ọcha, n'otu akụkụ ihe osise "51H", n'akụkụ nke ọzọ - akara nke ụlọ ọrụ ahụ.
Mbadamba 80 mg
Mbadamba ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke dị ọcha, n'otu akụkụ nke ihe osise "52H", n'akụkụ nke ọzọ - akara nke ụlọ ọrụ ahụ.

Ndị na-ere ọgwụ: angiotensin II antagonist.
Koodu ATX C09CA07

Ngwongwo ogwu
Mlọ ọgwụ
Telmisartan bụ onye antagonistin II na-anabata ihe mgbochi (ụdị AT1), dị irè mgbe a na-ewere ya ọnụ. Ọ nwere oke mmekọrịta dị mma maka AT1 subtype nke ndị na-anabata angiotensin II, site na nke a na-ahụ ihe omume nke angiotensin II. Na-egosiputa angiotensin nke m na njikọta na onye na-anabata ihe, na-ejighi ihe onye na-ekwu gbasara ihe gbasara onye nnata.
Telmisartan na ejikọ naanị AT1 ụdị nke ndị nnabata angiotensin II. Njikọ ahụ na-aga n'ihu. O nweghi nmekorita ya nye ndi nnabata ozo, tinyere ndi nnabata AT2 na ndi nnabata angiotensin di obere. Amamịghe ọrụ nke ndị nnabata ndị a, yana nsonaazụ nke ike ha nwere na angiotensin nke abụọ, amụchaghị nke na-abawanye na nhọpụta nke telmisartan. Ọ na -ebelata mkpụkọ aldosterone n'ọbara, anaghị egbochi mmiri renin na plasma ọbara ma ọ dịghị egbochi ụzọ ion. Telmisartan anaghị egbochi angiotensin na-agbanwe enzyme (kininase II) (enzyme nke na-akụda bradykinin). Yabụ, atụghị anya mmụba nke mmetụta n'akụkụ bradykinin kpatara.
N'ime ndị ọrịa, telmisartan na ọgwụ nke 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. A na-achọpụta mmalite nke hypotensive n'ime ọnwa 3 mgbe nchịkwa izizi nke telmisartan. Mmetụta ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo 48 awa. Mmetụta antihypertensive na-ebikarị izu anọ 4-8 mgbe ị regularụsịrị ya.
N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan lowers systolic na ọbara mgbali ọbara (BP) na-enweghị emetụta mmetụ obi (HR).
N'ihe banyere ịkagbu telmisartan na mberede, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya na enweghị mmepe nke “ngbanwe” ọrịa ahụ.

Mlọ ọgwụ
Mgbe a na -ewere ya okwu ọnụ, a na-etinye ya ngwa ngwa site na eriri afọ. Bioavailability nke -50%. Mgbe ewere nri n'otu oge, mbelata na AUC (mpaghara n'okpuru oge ịta ahụhụ) sitere na 6% (na kilogram 40) na 19% (na dose 160 mg). Mgbe awa 3 a malitesịrị ịbanye n'ọbara plasma ọbara, ọ gụpụrụ nri. Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. Cmax (ntinye uche kacha ukwuu) na AUC dị ihe dịka ugboro atọ na oge abụọ, otu, ka elu na ụmụ nwanyị ma e jiri ya tụnyere ndị nwoke na-enweghị nnukwu mmetụta na arụmọrụ.
Nkwukọrịta na protein protein plasma - 99.5%, tumadi na albumin na alfa-1 glycoprotein.
Ogo nke ogo ihe pụtara ìhè n’inweta nha anya bụ lita 500. A na-agagharị ya site na conjugation na glucuronic acid. Metabolites anaghị arụ ọrụ ọgwụ. Mkpochapu ọkara ndụ (T½) karịrị awa 20. Ọ na-ewepụta ya na eriri afọ na - agbanweghi, na - ewepụta site na akụrụ - ihe na - erughị 2%. Mkpochapu plasma dị elu (900 ml / min.) E jiri ya tụnyere usoro ọbara ọbara "ọria" (ihe dị ka 1500 ml / min.).
Ndị okenye na-arịa ọrịa
Pharmlọ ọgwụ ọgwụ telmisartan na ndị ọrịa agadi adịghị iche na ndị ọrịa na-eto eto. Dose ukpụhọde adịghị.
Ọrịa enweghị akụrụ
Achọghị mgbanwe mgbanwe nke oge a na ndị ọrịa nwere ọrịa akụrụ, gụnyere ndị ọrịa n'ọrịa metụtara akwara ụkwụ.
Achọpụghị Telmisartan.
Ndị ọrịa nwere ọrịa imeju
N'ime ndị ọrịa nwere ọrịa imeju na-arụ ọrụ dị nro ma na-agafe agafe (klas A na B n'ihe ọ̀tụ̀tụ̀ nwatakịrị ahụ).
Na ụmụaka
Ihe ngosiputa nke pharmacokinetics nke telmisartan na umuaka noo n’agbata afọ 6 ruo na iri na asatọ, n’ozuzu ha, yiri ihe data enwetara na ọgwụgwọ nke ndị toro eto, ma gosipụta na enweghị usoro nke pharmacokinetics nke telmisartan, ọkachasị n’ihe gbasara Cmax.

Ihe ngosi maka ojiji

Ọbara ọbara.
Mbelata obi na ọrịa obi na ọrịa na ndị ọrịa afọ 55 gbagoro ma nwee nnukwu ọrịa nke ọrịa obi.

Ihe ngbanwe

Ejikọtara onwe ya na ihe na-arụ ọrụ ma ọ bụ ihe enyemaka nke ọgwụ ahụ
Ime
Oge ịgba akwụkwọ
Ọrịa na-egbochi ọnya biliary
Ọrịa hepatic siri ike (-mụaka-Pugh klas C)
Mkpụrụ nke fructose anabataghị (nwere sorbitol)
Afọ ruo afọ iri na asatọ (anaghị arụ ọrụ na nchekwa adịghị)

Jiri nlezianya

Stenosis akwara klaasị ma ọ bụ stenosis nke otu akụrụ
Imeju na-arụ ọrụ na / ma ọ bụ ọrụ akụrụ (leekwa ntuziaka pụrụ iche),
Mbelata na-ekesa ọbara (BCC) n'ihi usoro ọgwụgwọ mbelata gara aga, mmachi nnu, afọ ọsịsa, ma ọ bụ vomiting
Hyponatremia,
Hyperkalemia
Ọnọdụ mgbe akụrụgharị akụrụ (enweghị ahụmịhe eji ya),
Ọrịa obi na-adịghị ala ala
Stenosis nke aortic na valvụ valve,
Idiopathic hypertrophic subaortic stenosis,
Aldosteronism nke mbu (arụmọrụ na nchekwa adịghị ike)

Usoro onunu ogwu na nhazi
N'ime, n'agbanyeghị nri.
Ọbara ọbara
Recommendednyịnya ọgwụ mbụ akwadoro Mikardis ® bụ taabụ 1. (40 mg) otu ugboro n'ụbọchị. N'ọnọdụ ebe enweghi ike nweta ọgwụgwọ, enwere ike ịba ụba nke ọgwụ Mikardis ® ka ọ bụrụ 80 mg otu ugboro n'ụbọchị. Mgbe ị na-ekpebi ma ịbawanye ọgwụ ahụ, ekwesịrị iburu n'uche na mmetụta antihypertensive kachasị na-arụkarị n'ime izu 4-8 mgbe mmalite nke ọgwụgwọ.
Mbelata na ọrịa obi na ọnwụ
Usoro a tụrụ aro bụ 1 mbadamba ọgwụ Mikardis ® 80 mg, m otu ugboro n'ụbọchị.
N’oge mmalite ọgwụgwọ, enwere ike ịchọ mgbazi ọbara mgbali elu ọzọ.
Renrụ ọrụ na-arụ ọrụ na ụlọ
N'ime ndị ọrịa nwere akụrụ gbasara akwara, gụnyere ndị ọrịa na-anwale hemodialysis, a chọghị ndozi usoro dosing regimen.
Ọrụ imeju na-arụ ọrụ
N'ime ndị ọrịa nwere ọrịa imeju na-adịghị arụ ọrụ nke ọma (klas A na B n'ọtụtụ Child-Pugh, dị iche iche), kwa ụbọchị Mikardis ® agaghị agafe 40 mg.
Ndị okenye na-arịa ọrịa
Usoro usoro usoro ọgwụgwọ adịghị achọ mgbanwe.

Mmetụta akụkụ
Ọnọdụ ndị a chọpụtara na nsonaazụ ndị ọzọ emetụtaghị na okike, afọ ma ọ bụ agbụrụ ndị ọrịa.
Ọrịa:
Sepsis, gụnyere sepsis na-egbu egbu, ọrịa urinary tract (gụnyere cystitis), ọrịa akụkụ okuku ume na elu.
Site na sistem na okirikiri ọbara:
Ọbara, eosinophilia, thrombocytopenia.
Si n'etiti ụjọ usoro:
Nchegbu, ura ehighị ụra, ịda mba, ịda mba.
Site na akụkụ ahụ nke ịhụ ụzọ na ịnụ ihe:
Nkịtị Anya, anya.
Si usoro obi:
Bradycardia, tachycardia, akara mbelata ọbara mgbali elu, orthostatic hypotension
Site na usoro iku ume:
Ntutu ume.
Site na nri digestive:
Mgbu afọ, afọ ọsịsa, akpịrị akpọ nkụ, dyspepsia, flatulence, erughị ala n’afọ, ọgbụgbọ, ọrụ imeju na-arịa.
Mmeghachi omume nfụkasị ahụ:
Mmeghachi omume anaphylactic, hypersensitivity na ihe na-arụ ọrụ ma ọ bụ ihe inyeaka nke ọgwụ ahụ, angioedema (egbu egbu), eczema, erythema, itching skin, fash (gụnyere ọgwụ), hyperhidrosis, urticaria, fashids na-egbu egbu.
Site na usoro mọzụlụ:
Arthralgia, mgbu azụ, ihe mgbu akwara (ngwụrọ nke akwara nke nwa ehi), ihe mgbu na nsọtụ nke ala, myalgia, ihe mgbu na akwara (akara yiri nke ngosipụta nke akwara).
Site na akụrụ na eriri afọ:
Ọrụ akụrụngwa na-arụ ọrụ, gụnyere nnukwu ọrụ gbasara akụrụ.
Ohaneze:
Obi mgbu, ọrịa na-efe efe dị ka ọrịa, asthenia (adịghị ike), hyperkalemia, hypoglycemia (na ndị ọrịa nwere ọrịa mellitus).
Nnyocha ụlọ nyocha:
Mbelata nke uche nke haemoglobin, mmụba nke mkpo acid uric, creatinine n'ọbara, mmụba nke ọrụ enzymes “imeju”, mmụba nke mkpokọta nke creatine phosphokinase (CPK).

Dodoụbiga ya ókè
Onwebeghi ọnọdụ ị ofụbiga mmanya ókè achọpụtala
Mgbaàmà: mbelatala mgbali ọbara, tachycardia, bradycardia.
Ọgwụgwọ: ọgwụgwọ Symptomatic, ịba ọcha n'anya adịghị arụ ọrụ.

Mmekọrịta na ọgwụ ndị ọzọ
Telmisartan nwere ike iwelie mmetụta hypotensive nke ndị ọrụ antihypertensive ndị ọzọ. Achọpụtaghị ụdị mmekọrịta ndị ọzọ dị mkpa nke ụlọ ọgwụ. Ihe jikọtara ya na digoxin, warfarin, hydrochlorothiazide, glibenclamide, ibuprofen, paracetamol, simvastatin na amlodipine anaghị eduga na mkparịta ụka dị egwu na ụlọ ọgwụ. Mmụba dị ịrịba ama na nkezi nke digoxin na plasma ọbara site na nkezi 20% (n'otu oge, pasent 39%). Site na nlekọta nke telmisartan na digoxin, ọ bụ ihe amamihe dị na ya ikpebi oge ịhapụ digoxin n'ọbara.
Site na iji telmisartan na ramipril na-eme n'otu oge, mmụba na AUC0-24 na Cmax nke ramipril na ramiprilat ugboro abụọ. Egosipụtaghi mkpa ogwu di egwu a.
Site na nlekọta nke angiotensin na-agbanwe ntụgharị enzyme (ACE) na nkwadebe lithium, a hụrụ mmụba na-atụgharị atụgharị nke lithium n'ọbara, yana mmetụta nsonaazụ. N'ọnọdụ ndị a na-adịghị ahụkebe, a kọọrọ mgbanwe ndị dị otú ahụ na nchịkwa nke ndị na-anabata angagonensin II antagonist. Site na nhazi nke lithium na angiotensin II antagonist antagonists, a na-atụ aro iji chọpụta mkpo lithium n'ime ọbara.
Ọgwụ na ọgwụ mgbochi na - abụghị ọgwụ steroidal (NSAIDs), gụnyere acetylsalicylic acid, cyclooxygenase-2 inhibitors (COX-2) na NSAIDs na - ahọrọghị, nwere ike ibute nnukwu ọrịa gbasara ndị ọrịa akpịrị. Ọgwụ na-eme ihe na sistemụ renin-angiotensin-aldosterone (RAAS) nwere ike inwe mmetụta synergistic. N'ime ndị ọrịa na-anata NSAIDs na telmisartan, bcc ga-akwụghachi ụgwọ na mbido ọgwụgwọ na ọrụ gbasara akụrụ.
Mbelata mmetụta nke ndị na - egbochi ọgwụ mgbochi, dịka telmisartan, site na mmachi nke mmetụta vasodilating nke prostaglandins ka a hụchara site na iji ọgwụgwọ na ndị NSAID.

Ntụziaka pụrụ iche
Somefọdụ ndị ọrịa, n'ihi nnabata nke RAAS, ọkachasị mgbe ị na-eji ọgwụ ọgwụ ndị na-eme ihe na sistemụ a, arụ ọrụ akụrụngwa (gụnyere nnukwu gbasara akụrụ akwara). Yabụ, usoro ọgwụgwọ a na-ejikọ ọnụ nke abụọ RAAS dị otu a ga-emerịrị kpamkpam n'otu n'otu yana jiri nlezianya na-elele ọrụ gbasara akụrụngwa (gụnyere nlebara anya oge nri nke potassium na creatinine.
N'ihe banyere ndabere nke akwara olu na ọrụ akụrụ tumadi na ọrụ RAAS (dịka ọmụmaatụ, na ndị ọrịa nwere nkụchi obi na-adịghị ala ala, ma ọ bụ ọrịa akụrụ, gụnyere akwara mkpọnwụ, ma ọ bụ stenosis akwara), nhọpụta ọgwụ nke na-emetụta usoro a, enwere ike ijikọ ya na mmepe nke hypotension hypotension, hyperazotemia, oliguria, na, n'oge ụfọdụ, nnukwu ọdịda gbasara akụrụngwa.
Dabere na ahụmịhe iji ọgwụ ndị ọzọ na-emetụta RAAS, ya na iji ọgwụ ndị Mikardis ® na ọgwụ ndị na-egbu ihe na-egbu egbu, ihe mgbakwunye potassium, nnu nke nwere potassium, yana ọgwụ ndị ọzọ na-eme ka nchịkọta nke potassium dị n'ọbara (dịka ọmụmaatụ, heparin), a ga-enyocha ihe ngosi a na ndị ọrịa.
N'aka ozo, enwere ike iji Mikardis ® mee ya na thiazide diuretics, dika hydrochlorothiazide, nke ozo nwere mmetụta hypotensive (dika imaatu, Mikardis Plus ® 40 mg / 12.5 mg, 80 mg /) 2.5 mg).
N'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba, ọnụọgụ nke telmisartan bụ 160 mg / ụbọchị yana mgbakwunye hydrochlorothiazide 12.5-25 mg nke ọma anabata ma dị irè. Mikardis ® adịchaghị irè na ndị ọrịa agbụrụ Negroid.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ
Emebeghị nnyocha ọmụmụ pụrụ iche banyere mmetụta ọgwụ nwere ike ịkwọ ụgbọ ala na usoro emebeghị. Agbanyeghị, mgbe ị na-anya ụgbọala na-arụ ọrụ na iji usoro, enwere ike ibute ọgbụgba na ụra ụra, buru n'uche ịkpachara anya.

Mpempe mwepụta
Mbadamba 40 mg na 80 mg.
Mkpụrụ mbadamba nkume asaa n'ime paịlị emere na polyamide / aluminom / PVC. 2 ma ọ bụ 4 na blisters nwere ntuziaka maka iji ya na igbe kaadi (maka usoro 40 mg). Maka blisters 2, 4 ma ọ bụ 8 nwere ntuziaka maka iji ya na igbe kaadi (maka usoro nke 80 mg).

Ọnọdụ nchekwa
Ndepụta B.
Chekwaa na nju okpomọkụ adighi 30 Celsius C n’ebe anabataghi ya.
Nọ ebe aka ndi umu aka!

Exbọchị mmebi
Afọ 4 Ejila oge emechaala.

Usoro ahịa ọgwụ ahịa
Site na ndenye ọgwụ.

Aha na adresị nke ụlọ ọrụ iwu nke enyere aha asambodo ndenye aha ya
Beringer Ingelheim International GmbH Bingsr Strasse 173,
55216, Ingelheim am Rhein, Germany

Emeputa
Beringer Ingelheim Pharma GmbH & Co.KG
Bingerstrasse 173, 55216 Ingelheim am Rhein, Germany

You nwere ike nweta ozi ndị ọzọ gbasara ọgwụ ahụ, zigakwa mkpesa gị na ozi gbasara ihe ọjọọ na adres na-esote Russia
Beringer Ingelheim LLC 125171, Moscow, Leningradskoye Shosse, 16A p. 3

Mpempe usoro onunu ogwu

Mbadamba 80 mg / 12.5 mg, 80 mg / 25 mg

Otu mbadamba ihe

bekee arụ ọrụ: telmisartan 80 mg

hydrochlorothiazide 12.5 mg ma ọ bụ 25 mg, n'otu n'otu

ndị na-ebu ụzọ: sodium hydroxide, polyvidone K 25 (povidone), meglumine, sorbitol, magnesium stearate, lactose monohydrate, celclose microcrystalline, ọka (III) na-acha ọbara ọbara (E172) (maka usoro onunu ogwu 80 / 12.5), iron (ІІІ) oji edo edo (Е172) (maka usoro onunu ogwu 80/25), sodium starch glycolate (ụdị A).

80 mg / 12.5 mg: Mbadamba ụcha dị mma nke nwere biconvex elu, nke nwere okpukpu abụọ: otu oyi akwa na-acha ọcha na mbipụta “H8” na akara ụlọ ọrụ ahụ, nke nwere ikike na-acha ọbara ọbara, nke ọzọ na-acha odo odo na-acha odo odo.

80 mg / 25 mg: Mbadamba ụcha dị mma nke nwere biconvex elu, nke nwere okpukpu abụọ: otu oyi akwa na-acha ọcha na akara ngosi “H9” na njikwa ụlọ ọrụ, nwere agba na-anabata agba agba, nke ọzọ na-acha odo odo.

Ngwongwo ogwu

Mlọ ọgwụ

Ojiji nke hydrochlorothiazide na telmisartan anaghị emetụta ọgwụ ọgwụ nke ọgwụ ndị a.

Telmisartan: mgbe nchịkwa ọnụ gasịrị, a na-etinye telmisartan ngwa ngwa, mkpokọta kachasị nke telmisartan na awa 0,5-1.5.

Onyinye zuru oke banyere telmisartan ruru 50%. Iri obere belata bioavailability nke telmisartan na mbelata na mpaghara n'okpuru usoro "oge ịta ụta plasma" (AUC) site na 6% mgbe ewere ya na 40 mg ruo 19% mgbe ewere ya na 160 mg. Mgbe awa 3 gachara telmisartan, ịta ụbara na plasma ọbara a kwụsiri ike ma ghara ịdabere na iri nri. Mbelata nke obere na AUC anaghị ebute mbelata nke arụmọrụ ọgwụgwọ.

Aclọ ọgwụ ọgwụ telmisartan mgbe a na-ewere ya bụ nke na-abụghị ahịrị na usoro onunu sitere na 20 mg ruo 160 mg yana mmụba dị ukwuu na mkpokọta plasma (Cmax na AUC) na-abawanye ụba. Telmisartan adịghị agbakọ na plasma ọbara n'ọtụtụ ebe yana iji ya ugboro ugboro.

Hydrochlorothiazide: mgbe nchịkwa ọnụ gasịrị, a na-enweta ntinye kachasị nke hydrochlorothiazide ihe dịka 1.0-3.0 awa mgbe nchịkwa gasịrị. Ezigbo bioavailability hydrochlorothiazide bụ ihe dịka 60%.

Telmisartan: nwere ikike dị elu na-egbochi protein ndị dị na plasma (> 99.5%), ọkachasị nwere albumin na alfa-1 acid glycoprotein. Olu nke nkesa dị ihe dị ka lita 500.

Hydrochlorothiazide: 64% dị na protein plasma na oke nkesa ya pụtara oji 0.80.3 l / n'arọ.

Metabolism na ntụpọ

Telmisartan: mgbe nchịkwa ọnụ nke 14C nke akpọrọ telmisartan, ọtụtụ ọgwụ (> 97%) ka abụpụtara na feces site na biliary excretion, ọ dịkwa obere mm ụta ka achọpụtara na mmamịrị. A na-agwakọta ya site na iji ihe dị n'ime ala ahụ rụpụta ọgwụ mmalite acylglucuronide, nke naanị glucuronide bụ mmadụ.

Mgbe nchịkwa nke otu 14C nke akara telmisartan, glucuronide achọpụtara n'ihe dị ka 11% nke redioachibidoro plasma tụọ. Cytochrome P450 isoenzymes anaghị esonye na metabolism nke telmisartan. Mkpokọta mkpokọ plasma nke telmisartan bụ ihe dị ka 1500 ml / min, njedebe ọkara ndụ nke ihe karịrị awa 20.

Hydrochlorothiazide: n'ime ụmụ mmadụ, ọ bụ metabolized ma kpochapụ ya ihe kpamkpam agbanweghi na mmamịrị. Ihe dịka 60% nke ọnụ a na-ahụ anya dị ka ihe na-agbanweghi agbanwe n'ime awa 48. Mkpochapu ntaramahụhụ dị ihe dịka 250-300 ml / min. Oge ndụ ọkara ikpeazụ nke hydrochlorothiazide bụ awa 10-15.

Ndị okenye na-arịa ọrịa: ọgwụ pharmacokinetics nke telmisartan na ndị ọrịa agadi na ndị na-erubeghị afọ 65 afọ adịghị iche.

Okike: ọkwa plasma nke telmisartan n'ime ụmụ nwanyị ji okpukpu abụọ dị elu karịa nke ụmụ nwoke. Agbanyeghị, n'ọmụmụ ihe gbasara ụlọ ọgwụ, enweghi oke mmụba na ọbara ọgbụgba ma ọ bụ onodu nkwalite orthostatic n'ime ụmụ nwanyị. Enweghị mkpa ịmegharị dose. Enwere echiche nke itinye uche nke hydrochlorothiazide na plasma ọbara dị elu karịa ụmụ nwoke.

Onweghi otutu mkpocha egwu telmisartan achoputara.

Ọrịa enweghị akụrụ

Rezọ ịgba ụgwọ adịghị emetụta mwepụ telmisartan. Site na ahụmịhe nke iji ọgwụ ahụ eme ihe na ndị ọrịa nwere obere ọdịda obere ahazi ahaghị (mwepu nke 30-60 ml / min, nkezi nke ihe dịka 50 ml / min), egosiri na idozi dose adịghị mkpa na ndị ọrịa nwere obere ọrụ gbasara ọrụ. Achọpụtaghị Telmisartan n'oge usoro ọgwụgwọ hemodial. N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, ọnụego mkpochapu hydrochlorothiazide belatara.

N'ime ihe omumu na ndi ọrịa nwere ikike okike okike 90 ml / min, ọkara nke hydrochlorothiazide mụbara. N'ime ndị ọrịa nwere akụrụ na-anaghị arụ ọrụ, ọkara ndụ iwepụ bụ ihe dịka 34 awa.

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere ọrịa imeju, enwere ịrị elu bioavailability zuru oke na 100%. Ọkara ndụ adịghị agbanwe na mmebi imeju.

Mlọ ọgwụ

MIKARDIS Plus bụ ngwakọta nke antagonistin II receptor antagonist - telmisartan na thiazide diuretic - hydrochlorothiazide. Njikọ nke ihe ndị a na-enye ọkwa dị elu nke mmetụta antihypertensive karịa iburu akụkụ nke ọ bụla iche. Remata MIKARDIS Plus otu ugboro kwa ụbọchị na usoro ọgwụgwọ ọgwụgwọ na-enye mbelata nke ọbara mgbali elu.

Telmisartan: Ọ bụ usoro antiotensin II receptor antagonist dị mma ma doo anya (ụdị AT1). Telmisartan nwere ezigbo mmekọrịta dị n'otu na-etolite njikọ naanị na AT1 subtype, ndị na-anabata angiotensin II. Telmisartan enweghị mmekọrịta maka ndị na-anabata ndị ọzọ, gụnyere AT2 - ndị na-anabata angiotensin, na ndị ọzọ, na-amụchaghị, ndị na-anabata ndị na-anabata AT. Amamịghe ọrụ nke ndị nnabata ndị a, yana nsonaazụ nke ike ha nwere na angiotensin nke abụọ, amụchaghị nke na-abawanye na nhọpụta nke telmisartan.

Telmisartan na-eduga n'ịbelata ọkwa aldosterone dị n'ọbara. Telmisartan anaghị egbochi renin na plasma mmadụ ma ọ dịghị egbochi ọtụ ụzọ dị na ya. Telmisartan anaghị egbochi ọrụ nke angiotensin na - agbanwe enzyme (kinase II), na ntinye nke enwere mbelata na njikọ bradykinin. Ya mere, enweghị ịrị elu na nsonaazụ ndị a na-akpata bradykinin.

N'ime ndị ọrịa, telmisartan na ọgwụ nke 80 mg fọrọ nke nta ka ọ gbochie mmetụta ọbara ọgbụgba nke angiotensin II. Mmetụta ahụ na-adịgide ruo awa 24 ma na-adịgide ruo ihe ruru awa 48.

Mgbe ị theụsịrị ọgwụ ọgwụ mbụ nke telmisartan, ọgwụ mmegharị ahụ na-eji nwayọ nwayọ achọpụta 3 awa. A na - enweta nwayọ na mbelata ọbara mgbali elu karịa izu anọ mgbe ebidochara ọgwụgwọ a ga - ejikwa ya ogologo oge.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan lowers systolic na ọbara mgbali ọbara na-enweghị ịgbanwe mgbanwe obi.

Ngwọta antihypertensive nke telmisartan yiri nke ndị ọzọ maka ọgwụ antihypertensive (dịka egosiri na ọmụmụ ụlọ ọgwụ na-atụnyere telmisartan na amlodipine, atenolol, enalapril, hydrochlorothiazide, losartan, lisinopril, ramipril, na valsartan).

N'ihe banyere ịkagbu telmisartan na mberede, ọbara mgbali ji nwayọọ nwayọọ na-alaghachikwute ụkpụrụ ahụ tupu a gwọọ ya ọtụtụ ụbọchị na-enweghị ihe ịrịba ama nke ịmaliteghachi ọbara mgbali elu (enweghị "nkwụsị").

N'ime omumu ihe omumu, ya na atughari uche nke uzo abuo a na aru ogwu, onodu nke okpomoku na ndi oria na - ebute telmisartan di ala karie na ndi na - anata angiotensin-enugitors enzyme.

Hydrochlorothiazide: bụ thiazide diuretic. Amaghị usoro nke antihypertensive mmetụta nke thiazide diuretics. Thiazides na-arụ ọrụ na sistem tubular toroal nke electrolyte reabsorption, na-abawanye ihie sodium na kloride na mkpokọ nha. Mmetụta diuretic nke hydrochlorothiazide na-ebelata oke olu nke plasma, na-eme ka ọrụ plasma renin dịkwuo elu, na-eme ka mmiri ọgwụ aldosterone na-esochi, mgbakwunye nke potassium na bicarbonate na-abawanye na mmamịrị na mbelata na potassium serum. Ihe mgbochi ngwụcha ngwụcha ngwụcha nke sistemụ renin-angiotensin-aldosterone mgbe ejikọtara ya na telmisartan na-eme ka mbibi potassium na-emetụta ya.

Mgbe ị na-ewere hydrochlorothiazide, a na-achọpụta mmụba nke diuresis mgbe elekere 2 gasịrị, mmetụta kachasị na-apụta mgbe ihe dị ka awa anọ gasịrị, ebe oge ọrụ ga-abụ ihe dịka awa 6-12.

Ọmụmụ Epidemiological egosila na ọgwụgwọ ogologo oge na hydrochlorothiazide na-ebelata ihe ize ndụ nke ọrịa obi na ọnwụ na ha.

Usoro onunu ogwu na nhazi

A na-eji MIKARDIS Plus otu ugboro n'ụbọchị.

Mgbe ị na-atụgharị na telmisartan ka MIKARDIS Plus, dose nke telmisartan nwere ike buru ibu na-abawanye. O kwere omume ntụgharị sitere na monotherapy rue na ị takingụ ọgwụ ngwakọta.

Enwere ike inye MIKARDIS 80 mg / 12.5 mg nye ndị ọrịa ebe ọgwụ telmisartan (MIKARDIS) 80 mg anaghị egbochi ọbara mgbali elu.

Enwere ike inye MIKARDIS Plus 80 mg / 25 mg nye ndị ọrịa ebe ọgwụ MIKARDIS gbakwunyere 80 mg / 12.5 mg anaghị egbochi ọbara mgbali elu ma ọ bụ ndị ọrịa ọnọdụ eburula ụzọ site na telmisartan ma ọ bụ hydrochlorothiazide mgbe ejiri ya iche.

Mmetụta antihypertensive kachasị na-arụkarị n'ime izu 4-8 mgbe mmalite ọgwụgwọ.

Ọ bụrụ na ọ dị mkpa, enwere ike ijikọ MIKARDIS na ọgwụ mgbochi ndị ọzọ.

N'ime ndị ọrịa nwere nnukwu ọbara mgbali elu, telmisartan na doses ruo 160 mg kwa ụbọchị (capsules abụọ nke MIKARDIS 80 mg) ma ọ bụ na njikọta hydrochlorothiazide 12.5-25 mg kwa ụbọchị (capsules abụọ nke MIKARDIS Plus 80 mg / 12.5 mg ma ọ bụ 80 mg / 25 mg) nabatara nke oma ma di ire.

A P beR M MIKARDIS Plus n'agbanyeghị nri nri.

N'ihi ọnụnọ nke MIKARDIS Plus hydrochlorothiazide na nkwadebe ahụ, ekwesighi inye ya ndị ọrịa nwere nnukwu akụrụngwa (mmebi nke creatinine)