Arthrosan Injection - Isi * Usoro maka Ọrụ

Ọgwụ dị n'ụdị mbadamba nkume. Isi ihe nọ n'ọrụ bụ pioglitazone na usoro nke 30 mg. Ihe ndi ozo mejuputara: lactose, magnesium stearate, hyprolose, ssumum croscarmellose.

A na-etinye mbadamba na paịlị mbadamba 10.

Na 1 mkpọ nke kaadiboodu nwere ike ịbụ 3 ma ọ bụ 6 nke ngwugwu ndị a. Ọzọkwa, enwere ike ịchọta ọgwụ ahụ na karama polymer (mbadamba 30 ọ bụla) na otu karama (mkpụrụ 30).

Omume ọgwụ

Ọkpụkpụ microbiology kpọrọ ọgwụ a dị ka usoro thiazolidinedione. Ọgwụ a bụ nhọrọ agonist nke ndị na-anabata gamma nke nanị isoenzymes.

N'ime ọrịa shuga mellitus nke ụdị nke abụọ, ọgwụ na-ebelata insulin iguzogide sel sel.

Enwere ike ịchọta ha na imeju, akwara na anụ ahụ adipose. N'ihi ihe ndị na-anabata ndị na-anabata ya, a na-agbanwe ntụgharị mkpụrụ ndụ ihe nketa nke e kpebiri na ọ ga - emeghari insulin ngwa ngwa. Ha na-etinyekwa aka na ịmeju glucose ọbara dị ala.

Usoro metabolism nke lipid metabolism na-alaghachikwa na nkịtị.

Ọkwa nke nguzogide anụ ahụ na - ebelata, nke na - eso akpata oriri ngwa ngwa glucose na - ebute insulin. Na nke a, ọ̀kwa dị ka Hemoglobin dị n'ọbara ọbara.

N'ime ọrịa shuga mellitus nke ụdị nke abụọ, insulin na-egbochi sel sel imeju. Nke a na - ebute mbelata glucose n'ọbara, ọkwa insulin na plasma na - agbada.

Mlọ ọgwụ

Mgbe ị theụchara ọgwụ ahụ na afọ na-enweghị isi, a na-ahụta pioglitazone kachasị na plasma ọbara mgbe ọkara elekere gachara. Ọ bụrụ na ị pụọ ọgwụ mgbe ị risịrị nri, mgbe ahụ ị nweta nsonaazụ ahụ n'ime elekere ole na ole. Bioav adị na itinye aka na protein ndị dị n'ọbara dị elu.

Metabolism Pioglitazone na-aputa imeju. Ọkara ọkara bụ ihe dịka awa asaa. A na-ewepụ ihe ndị na-arụ ọrụ n'ụdị metabolites yana mmamịrị, mmiri na feces.

A na - ewepụ ihe ndị na - arụ ọrụ nke Astrozone n'ụdị metabolites dị na mmamịrị.

Ihe ngbanwe

Ihe zuru oke mgbochi iji ọgwụ a bụ:

• hypersensitivity na mmiri,
• ụdị shuga 1
• ọrịa mamịrị ketoacidosis,
• nsogbu nke imeju na akụrụ,
• ime na lactation,
• ụmụaka gbara afọ 18,

Jiri nlezianya

Ekwesiri ịkpachara anya mgbe ị na-edegara ndị nwere akụkọ ntanetị ọgwụ:

• ọzịza
• anaemia
• mmeghari akwara obi.

Na-arịa ọrịa shuga

Y’oburu n’iji ogwu ahu ya na ndi ozo hypoglycemic ma obu metformin, ogwugwo kwesiri ibido n ’onodu a kacha nta. were ihe karịrị 30 mg kwa ụbọchị.

Nkwonkwo ọgwụgwọ na insulin gụnyere iji otu ọgwụ Astrozone na 15-30 mg ụbọchị, yana insulin na-adịgide otu ma ọ bụ jiri nwayọ belata, karịchaa n'ihe banyere hypoglycemia.

Nsonaazụ Astrozone

Na-akpata ọtụtụ oghom mmeghachi omume, nke nwere ike ịda site na oriri na-ekwesịghị ekwesị ma ọ bụ mebiri emebi doses.

Astrozone nwere ike ịkpalite nkụda obi.

N'ihe fọrọ nke nta ka ọ bụrụ n'ọnọdụ niile, ndị ọrịa nwere oke ọria. Nkwarụ anya nwere ike jikọta ya na mgbanwe na ọkwa glucose ọbara, ọkachasị na mmalite ọgwụgwọ. N'ọnọdụ ndị a na-adịghị ahụkebe, mmepe nke nkụda mmụọ na-ekwe omume.

Mmetụta ikike ịchịkwa usoro

N'ihi na n'ihi ojiji nke ọgwụ a, mmepe nke hypoglycemia ga-ekwe omume, yana nnukwu ọgbụgbọ na mgbakasị ahụ, ịkwesịrị ịjụ ịnya ụgbọ ala ma chịkwaa usoro ndị ọzọ dị mgbagwoju anya. Ọnọdụ a nwere ike imetụta ọnụego mmeghachi omume na itinye uche.

Should kwesịrị ịjụ ịnya ụgbọ ala n’oge a na-eji Astrozone agwọ ọrịa.

Ntụziaka pụrụ iche

N'iji nlezianya mee ọgwụ, a na-enye ndị ọrịa ọrịa edema oke ọgwụ, yana ịwa ahụ (tupu ịwa ahụ). Ọbara ana - ebilite (mbelata nke nwayọ nwayọ ọbara na - ebikọkarị na mmụba nke ọbara na - ebugharị n'ime arịa).

Nyochaa ọkwa nke hypoglycemia dị mkpa mgbe ị na-eji ọgwụgwọ yana njikọta na ketoconazole.

Jiri n'oge ime na lactation

Iwere mbadamba ụrọ bụ oge a na-emechi ya na n'oge a na-enye nwa ara. N'agbanyeghi na achoputara na umi ahu ike n’enweghi nsogbu teratogenic na omumu, odika ihapuru udiri omume a n’oge aturiri ime.

Iwere mbadamba Astrozone n’oge eji ara ara.

Doụbiga Astrozone

Onweghị nsogbu Astrozone zoro ezo achọpụtala na mbụ. Ọ bụrụ n ’ị takeụ ọgwụ n’echeghị anya, enwere ike ịbelata mmeghachi omume kachasị njọ nke ọrịa dyspeptik na mmepe nke hypoglycemia na-akpata.

N'ọnọdụ mgbaàmà njiri mara nke ịdoụbiga mmanya ókè, ọ dị mkpa ka a na-eme ọgwụgwọ Symptomatic ruo mgbe a ga-ewepụ ihe niile na-adịghị mma.

Ọ bụrụ hypoglycemia amalite ịmalite, ọgwụgwọ detoxification na hemodialysis nwere ike ịchọ.

Ọ bụrụ na hypoglycemia na-amalite site na ịjuju nke Astrozone, enwere ike ịchọ hemodialysis.

Mmekọrịta na ọgwụ ndị ọzọ

Mgbe ejiri ya na ọgwụ mgbochi ọnụ, a na-achọpụta mbelata siri ike na metabolites nke ihe na - arụ ọrụ. Ya mere, arụ ọrụ nke iji ọgwụ mgbochi egbochi ebelata.

Usoro metabolism nke pioglitazone na ọ fọrọ nke nta ka ọ bụrụ na a na-egbochi ya mgbe a na-ejikọ ya na ketoconazole.

Mmanya ndakọrịta

Nweghị ike iji ọgwụ were ọgwụ ị therapyụ ọgwụ gwọọ ọrịa. Nke a nwere ike ibute ịbawanye ụba na sistemụ ụjọ. Ihe-ọghọm nke tolitere dyspeptik na-abawanye. Ọrịa na-egbu egbu na-aba ụba n'ike n'ike.

Enwere otutu analogues nke Astrozone yiri ya na usoro nke ike na usoro ọgwụgwọ:

• Diab Norm
• Diaglitazone,
• Amalvia
• Pioglar
• Pioglite
• Piouno.

Exbọchị mmebi

O rughị afọ 2 site na ụbọchị emepụtara egosipụtara na ngwugwu. Ejila oge ngafe.

A na - ejikarị ike nke Astrozone eme ihe - a gaghị enwe ike iji ọgwụ Piuno mee ihe na njedebe ụbọchị.

Ngwakọta 1 ml

Meloxicam - 6.00 mg

Ndị pụrụ iche: meglumine - 3.75 mg, poloxamer 188 - 50,00 mg, tetrahydrofurfuril macrogol (glycofurol) - 100,00 mg, glycine - 5.00 mg, sodium chloride - 3.00 mg, 1 M sodium hydroxide solution - ka pH nke 8.2-8.9, mmiri maka injection - ruo 1 ml.

Otu ampoule (2.5 ml) nwere 15 mg nke meloxicam.

doro anya greenish-edo edo mmiri.

Nyocha Astrozone

Oleg, onye gbara afọ 42, Penza

Anọwo m ogologo oge na-arịa ọrịa shuga 2. Edere ọtụtụ ọgwụ, mana nsonaazụ ha anaghị adị oge ọ bụla anyị chọrọ. O kweghi m omume oge inje ogologo oge. Mgbe ahụ, dọkịta gwara m ka m drinkụọ ọgwụ Astrozone. Enwere m mmetụta nke ha ozugbo ezuru. Ọnọdụ izugbe dị mma ozugbo. N'afọ ole na ole, ọbara shuga dịghachiri dị ka ọ dị mma. N'okwu a, 1 mbadamba 1 ezuru ụbọchị dum. Enwere m afọ ojuju n'ihi ọgwụgwọ a.

Andrey, gbara afọ 50, Saratov

Dọkịta ahụ depụtara mbadamba nkume Astrozone na 15 mg kwa ụbọchị n'ihi eziokwu ahụ bụ na mmalite nke ọgwụgwọ enwere nyocha imeju na-adịghị mma. Ma usoro ọgwụgwọ ahụ enyereghị aka. Dọkịta tụrụ aro ka iwelie ọgwụ ahụ ruo 30 mg kwa ụbọchị, nke nyere nsonaazụ doro anya ozugbo. Site na nyocha ahụ, akara ngosi glucose belatara. Mmetụta ahụ dịgidere ogologo oge ruo mgbe ịkagbu ọgwụ ahụ. Mgbe nnwale ndị ahụ malitere ịka njọ, dọkịta depụtara usoro ọgwụgwọ mmegide nke 15 mg kwa ụbọchị. Sugar nwere ihe fọrọ nke nta ka ọ bụrụ otu afọ ugbu a, yabụ enweghị m ike ikwu ihe ọjọọ ọ bụla banyere ọgwụ ahụ.

Peter, gbara afọ 47, Rostov-on-Don

Ogwu adighị. Enweghi m mmetụta ọ bụla site na usoro ọgwụgwọ nke 15 mg. Dabere na nsonaazụ nyocha ndị ahụ, enweghịkwa mgbanwe pụrụ iche. Ozugbo etinyere ọgwụ ahụ ruo 30 mg, ọnọdụ ahụ dum kawanyere njọ ozugbo. Nnukwu ọbara ọgbụgba malitere, ihe mgbaàmà nke na-agwụ m ike. Aghaghị m dochie ọgwụ ahụ.

Mpempe mwepụta, ihe mejupụtara

Ọgwụ dị n'ụdị edozi maka nchịkwa intramuscular. Ihe ahụ bụ meloxicam dịka akụrụngwa na-arụ ọrụ. 1 ml nke ihe ngwọta nwere 6 mg nke meloxicam.

Dika ihe inyeaka bu glycine, sodium hydroxide, glycofurol, sodium chloride, mmiri maka injection.

N'ihi mmetụta ya, ihe na - arụ ọrụ nke ọgwụ kacha nta na - enye aka na mmepe nke mbuze ọnya afọ na duodenum.

Ofzọ nke ngwa, usoro onunu ogwu

Nkwekọrịta nke intramuscular nke ọgwụ ahụ ka amachibidoro n'ime ụbọchị mbụ mbụ nke ọgwụgwọ. N’ọdị n’ihu, a na-atụ aro ntụgharị aka nke ọgwụ a (ụ ọgwụ (mbadamba).

Usoro ọgwụgwọ a tụrụ aro ya kwa ụbọchị sitere na 7.5 ruo 15 mg. Dọkịta kpebiri na oge ọ ga-eji ọgwụ ndị ahụ mee ihe, na-eburu n'uche ngosipụta nke ọrịa ahụ na njirimara nke ahụ onye ọrịa.

Ndị ọrịa nọ n'ọrịa akwara ụkwụ ma nwee akụrụngwa akụrụkaka akụrụngwa akarịghị oke ọgwụ kwa ụbọchị nke 7.5 mg.

Achọghị ka Arthrosan gwakọta na otu sirinji ya na ọgwụ ndị otu ndị ọzọ. Anabataghị nchịkwa nchịkwa nke ọgwụ.

Mkpakọrịta na otu ọgwụ ọgwụ ndị ọzọ

Ekwesịrị iji ọgwụ ọjọọ a mee ihe mgbe ejiri ya mee ihe n'otu oge iji ọgwụ ọjọọ eme ihe site na otu anticoagulants (Warfarin), ndị nnọchi antiplatelet (Plavix, Clopidogrel), mmanya, corticosteroids mbadamba (Prednisolone), Fluoxetine, Paroxetine.

Ekwesighi iji Arthrosan na njikọ ya na ọgwụ ndị ọzọ site na otu ọgwụ ọgwụ mgbochi mkpali.

N'iji oge a, ana - eji nsogbu akwara ozi, ihe ọghọm nke etolite akwara na-abawanye.

N'iji ọgwụ ndị na-eme ọbara mgbali elu n'otu oge, mmetụta ha nwere ike ịdalata.

Mgbe ejikọtara ya na vitamin K, heparin, serotonin reuptake inhibitors, na fibrinolytics, ohere nke ọbara na-abawanye.

Nduzi ndi ozo

Site na mmepe nke mmeghachi omume anụ ahụ nke na-egosi imebi ọrụ akụrụ dị mma (itching na yellowness nke anụ ahụ, vomiting, mmamịrị gbara ọchịchịrị, ọnya afọ), ị ofụ ọgwụ ahụ kwesịrị ịkwụsị ozugbo ma gakwuru dọkịta.

Arthrosan nwere ike kpuchie ekpughe nke ọrịa na-efe efe.

Agaghị eji ọgwụ a mee ihe dịka proromlaxis nke thrombosis, n'agbanyeghị ike ya belata nchịkọta platelet.

Analogs nke injections Arthrosan

Ọgwụ ndị a bụ analogues nke nkwadebe Arthrosan: Melox, Amelotex, Mirlox, Mesipol, Movasin, Movalis. Ọ bụrụ n’ịchọrọ iji dochie ọgwụ, ị ga-ebu ụzọ kpọtụrụ dọkịta gị.

Ekwesịrị idobe ọgwụ injero Arthrosan n'ebe gbara ọchịchịrị, echedo ya site na ìhè anyanwụ kpọmkwem, n'ebe ụmụaka nọ. Ọnọdụ nchekwa - enweghị ihe karịrị ogo 25.

Pharmacodynamics na pharmacokinetics

Ihe eji arụ ọrụ meloxicam- weputara oksikama. Ọ nwere mmetụta mgbochi mkpali, igbochi njikọprostaglantins na enzyme chicooxygenase-2nke na-ekere òkè na okirikiri arachidonic acid.

N'okpuru nduzi nke meloxicam, ọrụ ndi ogbugbu ivu na permeability vaskụla mgbidimbelata nke ukwuu, braking na-eme mmeghachi omume na radicals n'efu. Nkụnwụ ahụ na-apụta n'ihi mbelata ọrụ nke njikọta prostaglantins yana akwara endings.

Enwetara oke ịkwụsi ike n'ime ụbọchị atọ na ụbọchị ise. Ọ na - ejikọ nke ọma na protein plasma (99% na karịa). Metabolizedna imeju, na-akpụ metabolites 4. Ha anaghị arụ ọrụ na usoro ọgwụ. A na - ekepụta metabolabolites na feces na mmamịrị n'ime oge 15 ruo 20 awa.

Ihe ngosi maka ojiji

na monotherapy na ndị ọrịa (ọkachasị ndị buru oke ibu) ndị anaghị enweta njikwa glycemic site na isoro nri ma na-eme mmega ahụ na onye nchịkwa nke metformin contraindicated,

yana metformin na ndị ọrịa (ọkachasị oke) ndị na-enwetaghị njikwa glycemic megide ndabere nke usoro ọgwụgwọ kachasị anabata nke metformin.

yana ọgwụ sulfonylurea dị na ndị ọrịa na-enwetaghị nchịkwa glycemic megide nzụlite nke usoro ọgwụgwọ sulfonylurea kachasị ekwenye na nke gọọmentị nke metformin mejupụtara,

yana usoro metformin na sulfonylurea na ndị ọrịa (ọkachasị ndị buru oke ibu) ndị anaghị enweta njikwa glycemic n'oge usoro ọgwụgwọ na usoro ọgwụgwọ metformin na sulfonylurea,

yana insulin na ndi ọrịa n’enweghi ike nchịkwa n'ime mmịnye a na - eme onye mejuputara nlekọta nke metformin.

Ntụziaka maka iji Arthrosan (Usoro na usoro onunu ogwu)

A na-ewere mbadamba otu ugboro n'ụbọchị, yana nri, jiri mmiri sachaa ya. Ọgwụ a na-atụ aro kwa ụbọchị sitere na 7.5 mg ruo 15 mg, dabere na ịdị ike nke ọrịa mgbu yana usoro nke ọrịa ahụ.

Ọ bụrụ na ọgwụ enweghị ike ị takenụ ya n'ọnụnwere ike ịhọpụta irighiri irighiri akwara.

Inje nke Arthrosan, ntuziaka maka ojiji

Edere injero ọrịa Arthrosan maka oke ihe mgbu n'ime ụbọchị mbụ ndị ọrịa. Ọgwụ ọgwụ ọjọọ na-emepụta intramuscularlymiri na akwa. Thebọchị kwa ụbọchị sitere na 7.5 ruo 15 mg, a na-amalite usoro ọgwụgwọ site na obere doses ma mụbaa ruo mgbe a ga-enweta nsonaazụ achọrọ.

Agaferela usoro ọgwụgwọ a tụrụ aro ya, ikekwe ịba ụba nke nsonaazụ ndị ọzọ.

Ngwongwo ogwu

Mlọ ọgwụ

Meloxicam bụ ọgwụ mgbochi anti-mbufụt (NSAID), na-ezo aka na enolic acid ma nwee mmetụta mgbochi, analgesic na antipyretic. Ekwuputara ọgwụ mgbochi mkpali nke meloxicam na ụdị usoro mbufụt niile. Usoro nke usoro nke meloxicam bụ ikike ya igbochi njikọ nke prostaglandins, ndị mgbasa ozi amara ama ama. Na vivo meloxicam na - egbochi ịrọkọta prostaglandin na saịtị nke ọnya nwere oke karịa na mucosa gastric ma ọ bụ akụrụ.

Ejikọtara ọdịiche ndị a na mgbochi nhọrọ cyclooxygenase-2 (COX-2) ma e jiri ya tụnyere cyclooxygenase-1 (COX-1). A kwenyere na mgbochi nke COX-2 na-enye nsonaazụ ọgwụgwọ nke NSAIDs, ebe mgbochi nke COX-1 isoenzyme oge niile nwere ike ibu ọrụ maka nsonaazụ ndị si na afọ na akụrụ. A choputara ihe choputara nke meloxicam n'ihe banyere COX-2 n'usoro nyocha di iche iche, ma na vitro na vivo. A na-egosi ike nhọrọ nke meloxicam igbochi COX-2 mgbe ị na-eji ọbara mmadụ dum dị ka usoro nnwale.

E guzobere na meloxicam (na usoro nke 7.5 na 15 mg) na-egbochi COX-2 nke ọma karị, na-arụ ọrụ dị ukwuu na inhibitory na mmepụta nke prostaglandin E2 na-akpali site na lipopolysaccharide (mmeghachi omume nke COX-2 na-achịkwa) karịa mmepụta nke thromboxane, nke na-etinye aka na ọbara ọbara. (mmeghachi omume nke COX-1 na-achịkwa).Mmetụta ndị a nwere ọgwụ dabere na ya. Ọmụmụ nyocha nke vi vivo gosipụtara na meloxicam (na usoro nke 7.5 mg na 15 mg) enweghị mmetụta na nchịkọta platelet na oge ọbara ọgbụgba.

Na omumu ihe omumu, ogwu uto site na eriri afọ (GIT) n'ogologo ebilitela obere oge mgbe ị na-ewere meloxicam 7.5 na 15 mg karịa mgbe ị na-ewere NSAID ndị ọzọ eji tụnyere ntụnyere. Ọdịiche a na nsonaazụ nke nsonazụ akwara na-abụkarị n'ihi eziokwu ahụ bụ na mgbe ị na-ewere meloxicam, ihe na-apụtakarịghị ike dịka dyspepsia, vomiting, ọgbụgbọ, mgbu afọ. Ugboro nke perforations na elu eriri afọ, ọnya na ọbara ọgbụgba, nke metụtara ojiji nke meloxicam, dị ala ma dabere na oke ọgwụ ahụ.

Mlọ ọgwụ

A na-etinye Meloxicam kpamkpam mgbe nchịkwa intramuscular gasịrị. Mkpakọrịta bioavailability dịnụ ma e jiri ya tụnyere bioavailability ọnụ bụ ihe fọrọ nke nta ka ọ bụrụ 100%. Yabụ, mgbe a na-agbanwe ịgbanwe ọgwụ injection ọ bụla ịhọrọ ya. Mgbe nchịkwa nke 15 mg nke ọgwụ ọgwụ intramuscularly, a na-etinye ọnụ ọgụgụ kachasị elu plasma (ihe dịka 1.6 - 1.8 μg / ml) n'ime ihe dị ka nkeji 60 - 96.

Meloxicam na - ejikọ protein na plasma nke ọma, ọkachasị na albumin (99%). Penetrates n'ime mmiri synovial ahụ, itinye uche na mmiri synovial bụ ihe dị ka 50% nke ịkpụkpọ plasma. Olu nke nkesa dị ala, ihe dịka 11 lita. Ndịiche dị iche iche bụ 7-20%.

Meloxicam bụ ihe fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju na ịmepụta 4 ọgwụ ọgwụ na-adịghị arụ ọrụ. Ihe bụ metabolite bụ isi, 5-carboxy-meloxicam (60% nke dose), bụ nke a na-eme ka ọ bụrụ ihe na - eme ka ọ bụrụ ihe anakpo metabolite, 5-hydroxymethylmeloxicam, nke a na - ewepụtakwa ya, mana ruo obere ala (9% nke dose). Nnyocha ọmụmụ vitro egosila na CYP2C9 isoenzyme na-arụ ọrụ dị mkpa na mgbanwe mgbanwe metabolic a, na CYP3A4 isoenzyme na-arụ ọrụ ndị ọzọ. Na nguzobe nke metabolites abuo ndi ozo (mejuputara, dika onodu 16% na 4% nke ogwu), peroxidase bu ihe ndi ozo, nke omume nwere ike di iche na ndi ozo. Ojiji

A na-ekewa ya n ’otu akụkụ eriri afọ na akụrụ, ọkachasị n’ụdị metabolites. N’ọnọdụ na-agbanweghi, ihe na-erughị 5% nke ọgwụ a na-ahụ kwa ụbọchị nwere agịga, na mmamịrị n’ụdị na-agbanweghi agbanwe, ọgwụ ahụ na-enweta naanị n ’usoro ọnụọgụ. Nkezi iwepu ọkara ndụ nke meloxicam dịgasị site na awa 13 ruo 25. Plasma nwechara ihe dị ka 7-12 ml / min mgbe ejiri otu ugboro. Meloxicam gosipụtara ọgwụ linear na usoro nke 7.5-15 mg na nchịkwa intramuscular.

Enweghị umeji na / ma ọ bụ ọrụ akụrụ

Enweghị ọrụ imeju, yana ọdịda akwara dị nro, anaghị emetụta ọgwụ ọgwụ nke meloxicam nke ukwuu. Ọnụego mkpochapụ abụba dị na ahụ dị elu karịa na ndị ọrịa nwere obere akwara na-ada ada. Meloxicam yikarịrị ka ọ ga-ejikọ protein ndị dị na plasma na ndị ọrịa nwere ọdịda mgbazinye ọkwa. Na ọdịda renal ọdịda, mmụba nke olu nkesa nwere ike ibute ịdị elu nke meloxicam n'efu, yabụ na ndị ọrịa a, ọgwụ kwa ụbọchị ekwesịghị ịkarị 7.5 mg.

Ọrịa ndị agadi nwere ike iji ha tụnyere ndị ọrịa na-eto eto nwere usoro ọgwụ ọgwụ ahụ yiri ya. N’ime ndị ọrịa meworo agadi, mkpochasị ọbara nke plasma n’oge ikike izizi dị obere karịa na ndị ọrịa na-eto eto. Womenmụ nwanyị meworo okenye nwere ụkpụrụ AUC dị elu (mpaghara n'okpuru oge ịta ahụhụ) na ogologo oge iwepụ ọkara ndụ, ma e jiri ya tụnyere ndị ọrịa na-eto eto nke ma nwoke ma nwanyị.

Usoro onunu ogwu na nhazi

Osteoarthritis na mgbu: 7.5 mg kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ a ruo 15 mg kwa ụbọchị.

Ọrịa ogbu na nkwonkwo: 15 mg kwa ụbọchị. Dabere na ọgwụgwọ ọgwụgwọ, enwere ike belata ọgwụ a na 7.5 mg kwa ụbọchị.

Spondylitis na-egbu mgbu: 15 mg kwa ụbọchị. Dabere na ọgwụgwọ ọgwụgwọ, enwere ike belata ọgwụ a na 7.5 mg kwa ụbọchị.

N'ime ndị ọrịa nwere oke ihe ize ndụ nke mmeghachi omume ọjọọ (akụkọ ihe mere eme nke eriri afọ, ọnụnọ nke ihe ize ndụ maka ọrịa obi), a na-atụ aro ịmalite ọgwụgwọ site na iji 7.5 mg kwa ụbọchị (lee akụkụ "Ntuziaka Pụrụ Iche"). N'ime ndị ọrịa nwere nnukwu akụrụ siri ike nke na-anabataghị usoro akụrụngwa, ọ̀tụ̀tụ̀ ahụ ekwesịghị gafere 7.5 mg kwa ụbọchị.

Nkwado izugbe

Ebe ọ bụ na enwere ike ịnwe mmeghachi omume na-adabere na ọnụọgụ na oge ọgwụgwọ, ekwesịrị iji obere elele yana oge ole eji ya. Oke kachasị tụrụ aro kwa ụbọchị bụ 15 mg.

Ejikọtara ojiji

Shouldkwesighi iji ọgwụ ahụ otu oge na ndị NSAID ndị ọzọ. Mkpokọta ọgwụ kwa ụbọchị Arthrosan® ejiri mee ihe n'ụdị usoro dịgasị iche ekwesịghị gafere 15 mg.

A na-egosipụta nchịkwa intramuscular nke ọgwụ naanị n’ime ụbọchị ole na ole mbụ nke ọgwụgwọ. Ọga n'ihu n’iji usoro nke onunu ogwu eme ya. Usoro a tụrụ aro bụ 7.5 mg ma ọ bụ 15 mg 1 oge kwa ụbọchị, dabere na ihe mgbu na ogo nke usoro mbufụt.

A na-ahụ maka ọgwụ ahụ site na ntụtụ nke intramuscular.

Enweghi ike inye ọgwụ ahụ intravenously.

Nyere ohere nke Arthrosan ga - ekwe omume, ihe ngwọta maka nchịkwa intramuscular ekwesịghị agwakọta na otu sirinji ya na ọgwụ ndị ọzọ.

Mmetụta akụkụ

A kọwara mmetụta dị n'okpuru ebe a, a na-ewere mmekọrịta nke iji ọgwụ egwu egwu dị ka o kwere mee.

Nsonaazụ ndị edere n'oge a na-ere ahịa mgbere, a na-ahụta mmekọrịta nke iji ihe na-egosi ọgwụ dị ka o kwere mee, ejiri akara *.

Ejiri usoro ndị a n'ime usoro nke sistemu ahụ yana oge ole ọ bara:

otutu oge (> 1/10),
Ọtụtụ mgbe (> 1/100. 1 / 1,000. 1 / 10,000) Ọbara site na ọbara na sistem lymphatic:

N'oge na-adịghị anya - leukopenia, thrombocytopenia, mgbanwe na ọnụ ọgụgụ sel ọbara, gụnyere mgbanwe na usoro leukocyte.

Ọrịa sistemụ immune:

N’oge na-adịghị anya, mmeghachi mmekpa ahụ ozigbo ozigbo *, Achọpụtaghị ya - anaphylactic jijiji *, mmeghachi anaphylactoid. Nsogbu uche: N’oge na-adịbeghị anya - mgbanwe ọnọdụ *,

Ezighi ntọala - ọgba aghara *, esemokwu *. Ọrịa sitere na sistem ụjọ: Ọtụtụ mgbe - isi ọwụwa, N’oge na - adịghị anya, ihi ụra.

Mmebi nke akụkụ nke ahụ nke ọhụhụ, ntị na nhụsianya labyrinth: Ugboro - vertigo,

N'oge na-adịghị anya - conjunctivitis *, nkwarụ anya, gụnyere ọhụhụ ọhụụ *, tinnitus. Nmebi nke obi na akwara ọbara:

N’oge na-adịghị anya - mmụba nke ọbara mgbali elu, mmetụta nke “ịsọ ọsọ” ọbara n’iru, N’oge na-adịghị anya - obi ọgbụgba.

Mmebi nke usoro iku ume:

N’oge na-adịghị anya - ụkwara ume ọkụ na-arịa ụkwara ume ọkụ na ndị ọrịa nfụkasị Acetylsalicylic acid na ndị NSAID ndị ọzọ.

Imebi ọnya ọgbụgba na - arụ ọrụ: Mgbe mgbe - mgbu afọ, dyspepsia, afọ ọsịsa, ọgbụgbọ, ọgbụgbọ,

N’oge na-adịghị anya - ọnya afọ na-egbu oge ma ọ bụ nke nwere eriri afọ, gastritis *, stomatitis, afọ ntachi, bloating, belching, Udiri - ọnya gastroduodenal, ọnya afọ, esophagitis, adịkarịsịrị - perforation of the gastrointestinal tract. Nmebi nke imeju na ọnya biliary:

Ugboro ugboro - mgbanwe dị iche iche na ntinye ọrụ nke imeju (dịka ọmụmaatụ, ịba ụba ọrụ nke transaminases ma ọ bụ bilirubin), adịkarịghị - ịba ọcha n'anya *.

Ọrịa site na anụ ahụ yana akwara dị n'okpuru ala: Na - adịghị ala ala - angiotek *, itching, ọnya ọnya,

Uri ala a na-egbu egbu *, Stevens-Johnson syndrome *, urticaria,

Ọ na-esighi ike - bulmatry dermatitis *, erythema multiforme *, Achọpụtaghị - fotoensitivity.

Nmebi nke akụrụ na akwara:

Ugboro ugboro - mgbanwe na ngosipụta nke ọrụ akụrụ (ụba creatinine na / ma ọ bụ urea n'ọbara ọbara), nsogbu nke urination, gụnyere nnukwu njigide urinary *,

Ọ dị ụkọ - nnukwu nnukwu akwara *.

Mmebi nke agbụrụ na mammary glands:

Ugboro ugboro - oge ovu *,

Emezighi - amụghị ụmụ na ụmụ nwanyị *.

Ọrịa na nkwarụ izugbe na saịtị ịgba ahụ:

Ọtụtụ mgbe - ihe mgbu na ọzịza na ebe ntụtụ,

Iji ọgwụ mee ihe na-egbochi ụmị ọkpụkpụ (dịka ọmụmaatụ methotrexate) nwere ike ịkpalite cytopenia.

Ọbara afọ, ọnya afọ, ma ọ bụ imegharị anya nwere ike igbu mmadụ.

Banyere ndị NSAIDs ndị ọzọ, ha anaghị ewepụ ohere nke ọdịdị nke nephritis interstitial, glomerulonephritis, renal medullary necrosis, na ọrịa nephrotic.

Mmekọrịta na ọgwụ ndị ọzọ

Ihe ndị ọzọ na - egbochi prostaglandin njikọ, gụnyere glucocorticoids na salicylates, ojiji a na-ejikọ ya na meloxicam na - ebulite ohere nke ọnya na eriri afọ na ọbara ọgbụgba (n'ihi mmekọrịta nke ihe). Ekwesighi iji NSAID ndị ọzọ emekọrịta ihe. Anticoagulants maka nchịkwa ọnụ, heparin maka iji ya mee ihe, ndị na - eme thrombolytic - nchịkwa nke imekotaotu onwe ya na meloxicam na - ebute nsogbu ọbara ọgbụgba. N'ọnọdụ n'otu oge, ọ dị mkpa iji nlezianya nyochaa usoro coagulation ọbara.

Ọgwụ Antiplatelet, ọgwụ serotonin reuptake inhibitors, ojiji a na-ejikọ ya na meloxicam na-eme ka ọbara ọgbụgba dịkwuo njọ n'ihi ihe a na-egbochi ọrụ platelet. N'ọnọdụ n'otu oge, ọ dị mkpa iji nlezianya nyochaa usoro coagulation ọbara.

Nkwadebe Lithium - NSAIDs na-abawanye ọkwa nke lithium na plasma site na ibelata mkpụmkpụ ya site na akụrụ. A naghị atụ aro iji abụ abụba a na-ejikarị eme ihe maka lithium. Ọ bụrụ na ọ dị mkpa, n'otu oge ahụ, iji nlezianya na-eleba anya n'oké lithium na plasma n'oge usoro lithium.

Methotrexate - NSAIDs na - ebelata akụrụngwa nke methotrexate site na akụrụ, ma si otú a na - amụba itinye uche ya na plasma. A na-atụ aro ka iji abụ abụba na-egbu egbu na methotrexate (na ọnụọgụ karịrị 15 mg kwa izu). Ọ bụrụ na ịgagharị n'otu oge, ọ dị mkpa iji nlezianya nyochaa ọrụ gbasara akụrụngwa na ọnụ ọgụgụ ọbara. Meloxicam nwere ike ịba ụba mmadụ na-egbu oke nke methotrexate, ọkachasị ndị ọrịa nwere ezigbo ọrụ ezumike.

Mgbochi - enwere ihe akaebe na NSAID nwere ike belata arụmọrụ nke ngwaọrụ intrauterine, mana egosighi nke a.

Diuretics - iji NSAIDs mee ihe mgbe akpịrị na-arịa ọrịa na-esonyere ya na nnukwu ihe gbasara akụrụ.

Ndị na - egbochi Antihypertensive (beta-blockers, angiotensin-na - agbanwe enzyme inhibitors, vasodilators, diuretics). NSAIDs na-ebelata mmetụta nke ọgwụ ọgwụ na-egbochi ihe mgbochi, n'ihi mgbochi nke prostaglandins na njikwa vasodilating.

Ndị na-anabata Angiotensin II na ndị na-anabata antagonensin, yana ndị na-egbochi enzyme enzyme mgbe ejikọtara ha na NSAIDs, na-eme ka mmụba nke glomerular, nke nwere ike ibute mmepe nke nnukwu gbasara akụrụngwa akarị, ọkachasị ndị ọrịa nwere ọrụ mgbazinye nsogbu.

Colestyramine, na - ejikọ ya na egwu dị na eriri afọ, na - eduga ya na ngwa ngwa.

Pemetrexed - na ojiji nke meloxicam na pemetrexed na ndị ọrịa mkpochapu site na 45 ruo 79 ml / min, a ga-akwụsị meloxicam ụbọchị ise tupu mmalite nke pemetrexed ma enwere ike ịmaliteghachi ụbọchị 2 mgbe ngwụsị nke dose ahụ. Ọ bụrụ na ọ dị mkpa maka ijikọ abụba na pemetrexed, ọ bụrụ na a ga-enyocha ndị ọrịa dị otú a, ọkachasị gbasara myelosuppression na omume nke nsonaazụ na eriri afọ. N'ime ndị ọrịa nwere nhichapụ ihe na-erughị 45 ml / min, iwere meloxicam na pemetrexed.

NSAIDs, na-eme ihe na prostaglandins renal, nwere ike iwelie nephrotoxicity cyclosporin.

Mgbe ejiri ya mee ihe na ọgwụ ọgwụ meloxicam nke nwere ike amaara igbochi CYP 2C9 na / ma ọ bụ CYP ZA4 (ma ọ bụ enzymes ndị a metabolized), dị ka sulfonylureas ma ọ bụ probenecid, enwere ike ibute mmekọrịta nke ọgwụ pharmacokinetic. Mgbe ejikọtara ya na ndị nnọchi ọgwụ antidiabet maka nchịkwa ọnụ (dịka ọmụmaatụ, ihe dị n'ụkpụrụ sulfonylurea, nateglinide), mmekorita nke CYP 2C9 nke onye mgbasa ozi bụ CGP 2C9 bụ nke enwere ike ibute mmụba nke ọgwụ abụọ a na meloxicam n'ọbara. Ndị ọrịa na-a meloụ ọgwụ a na-akpọ meloonyam ma ọ bụ na ndọkụrịta kwesịrị iji nlezianya nyochaa shuga ọbara ha n'ihi ọrịa hypoglycemia.

Site na ojiji nke antacids, cimetidine, digoxin na furosemide, enweghi mmekọrịta dị iche iche nke ọgwụ pharmacokinetic.

Usoro onunu ogwu na nhazi

A na-eji ọgwụ ndị metụtara Arthrosan naanị ụbọchị ole na ole mbụ ọgwụgwọ otu ugboro kwa ụbọchị, na 7.5 ma ọ bụ 15 ml, mgbe emesịrị iji mbadamba ọgwụ na-aga n'ihu. N'ihi ihe egwu dị na nsonaazụ ndị ọzọ, a na-atụ aro ka ị theụ ọgwụ a opekata mpe. A ga-agwọrịrị ya na Arthrosan naanị intramuscularly ọ naghị atụ aro ka ị gwakọta ọgwụ ahụ n'otu sirinji yana ọgwụ ndị ọzọ.

A na-ewere mbadamba Arthrosan otu ugboro n'ụbọchị, ọkacha mma na nri. Oke kachasị kwa ụbọchị bụ 15 mg. Usoro onunu ogwu dabere na oria a:

• Jiri osteoarthrosis, were otu mbadamba nkume nke Artrozan 7.5 mg, na enweghị mmetụta ọ bụla, enwere ike ịgbanye okpukpu abụọ,
• Usoro a na-atụ aro kwa ụbọchị maka ọrịa ogbu na nkwonkwo bụ 15 mg, mgbe ọ nwesịrị nkwalite, enwere ike belata ọgwụ ahụ na 7.5 mg kwa ụbọchị,
• Site na ankylosing spondylitis, were otu mbadamba mkpụrụ ọgwụ Arthrosan 15 mg kwa ụbọchị.

Dabere na ntuziaka maka Arthrosan, n'ihe banyere oke ị ,ụbiga mmanya ókè, mgbu nke epigastric, nsụchi azụ, ọgbụgbọ, njide iku ume, ọgbụgbọ, oke akụrụ na ọrịa ịba ọcha n'anya, asystole nwere ike ime.

Ekwesịrị ịkpachara anya mgbe ị na-eji Arthrosan na ọgwụ antihypertensive, methotrexate, diuretics, cyclosporine, nkwadebe lithium, na ụfọdụ ọgwụ ndị ọzọ. Ọdịmma ọbara ọgbụgba si eriri afọ na-abawanye site na iji ọgwụ Arthrosan na-ejikọ ya na ọgwụ mgbochi ndị ọzọ na - abụghị steroidal, gụnyere acid acetylsalicylic.

Eji Arthrosan jiri akpachapụ anya mee ọnya ọnya afọ nke anamnesis na agadi.

Nyocha banyere Arthrosan

Nyocha banyere inje nke Arthrosan dị mma. Ọgwụ a adịghị ọnụ ma dịkwa oke mma. Ọtụtụ nyere aka ịnagide ihe mgbu na ọrịa nkwonkwo dị iche iche. Iwe ọgwụ nwere otu mmetụta dị ka inje. N'ime minit ndị ahụ, a na-ahụkarị nsonaazụ n'ụdị isi ọwụwa, mgbu afọ na ọgbụgba, mana nke a na-eme n'esepụghị aka.