Etu esi eji ọgwụ ọgwụ Augmentin SR?

Ọrịa nje na-akpata site n’ọbara ndị na-akpata ọrịa: ọrịa akụkụ nke akụkụ okuku ume na akwara (ụkwara akwara, oyi baa, pleural empyema, ọnya afọ), ọrịa nke akụkụ ENT (sinusitis, tonsillitis, otitis media), ọrịa nke usoro akwara mkpụrụ ndụ na akụkụ ahụ (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, nje vaginitis, septiptik, postpartum sepsis, pelvioperitonitis, softcre, gonorrhea), ọrịa nke anụ ahụ na anụ ahụ dị nro (erysipelas, impetigo, nke abụọ. ma nje dermatoses, ahụ etuto, cellulitis, ọnya ọrịa), osteomyelitis, postoperative-efe efe, mgbochi nke na-efe efe na ịwa ahụ.

Mpempe usoro onunu ogwu

Mkpokọta palụ maka mbadamba nchịkwa, mbadamba ụrọ maka nkwadebe nke ihe ngwọta maka nchịkwa intravenous, mbadamba ụrọ maka nkwadebe nke ihe ngwọta maka nchịkwa intravenous.

Ihe ngbanwe

Hypersensitivity na ihe ndị mejupụtara Augmentin CP (gụnyere cephalosporins na ọgwụ mgbochi beta-lactam ndị ọzọ), mononucleosis na-efe efe (gụnyere ọdịdị nke ọrịa akpịrị), phenylketonuria, akụkụ nke jaundice ma ọ bụ ọrụ imeju na-adịghị mma n'ihi ojiji nke amoxicillin / clavulanova akụkọ ihe mere eme nke acid, CC erughị 30 ml / min (maka mbadamba 875 mg / 125 mg).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-enye doses nke Augmentin SR na usoro nke amoxicillin. Usoro usoro onunu ogwu a ka edobere n’otu n’otu dabere ogo oru ya na ebe oria di, omimi nke pathogen.

Undermụaka na-erubeghị afọ iri na abụọ - n’ụdị nkwado nke LF ndị ọzọ nwere otu ihe eji arụ ọrụ: ngwụcha, sirop ma ọ bụ ọdịda maka nchịkwa ọnụ. Otu setịpụrụ na-adabere n’afọ: ụmụ rue ọnwa 3 - 30 mg / kg / ụbọchị n’ime usoro onwa abụọ kewara, ọnwa atọ na karịa - maka ọrịa oria dị nro - 25 mg / kg / ụbọchị n’ime usoro onyonyo abụọ kewara ma ọ bụ 20 mg / kg / ụbọchị n’ime usoro 3, yana ọrịa siri ike - 45 mg / kg / day na doses 2 ma ọ bụ 40 mg / kg / ụbọchị na usoro 3.

Ndị okenye na ụmụaka karịrị afọ 12 ma ọ bụ na-eru 40 n'arọ ma ọ bụ karịa: 500 mg 2 ugboro / ụbọchị ma ọ bụ 250 mg ugboro atọ / ụbọchị. N'ime ọrịa dị egwu na ọrịa iku ume - 875 mg ugboro 2 / ụbọchị ma ọ bụ 500 mg ugboro 3 / ụbọchị.

Ihe kachasị maka ọgwụ kwa ụbọchị maka ndị okenye na ụmụaka karịrị afọ 12 bụ 6 g, maka ụmụaka na-erubeghị afọ 12 - 45 mg / n'arọ ahụ.

Ogo kachasị nke ụbọchị Clavulanic acid maka ndị okenye na ụmụaka karịrị afọ 12 bụ 600 mg, maka ụmụaka na-erubeghị afọ 12 - 10 mg / n'arọ ahụ.

N'itinye ọnụ ilo ihe na ndị okenye, a na-atụ aro iji nkwugbu ahụ.

N'ọnọdụ ọdịda akụrụngwa na-adịghị ala ala, a na-ahazi otu ugboro na ugboro ole (nchịkwa nke nkwadebe LF nke nwere otu ihe ahụ na - arụ ọrụ site na ndị ọzọ na - emepụta) dabere na QC: na QC karịrị 30 ml / min, a chọghị ịmegharị dose, na QC 10-30 ml / min: n'ime - 250- 500 mg / ụbọchị kwa awa 12 ọ bụla, na CC erughi 10 ml / min - 1 g, mgbe ahụ 500 mg / ụbọchị iv ma ọ bụ 250-500 mg / ụbọchị ọnụ na otu aga. Maka ụmụaka, ekwesịrị belata ọgwụ ahụ n'otu ụzọ ahụ.

Ndị ọrịa na hemodialysis - 250 mg ma ọ bụ 500 mg nke Augmentin CP nke ọnụ na otu usoro, mgbakwunye 1 ọzọ n'oge usoro ọgwụgwọ yana 1 ọzọ na njedebe nke nnọkọ.

Omume ọgwụ

Nchikota nke amoxicillin na clavulanic acid, ihe mgbochi beta-lactamase. Ọ na-eme ihe na-egbochi ahụhụ, na-egbochi njikọ nke mgbidi nje.

Na-arụ ọrụ megide nje aerobic gram-positive (gụnyere beta-lactamase na-emepụta nsogbu): Staphylococcus aureus,

nje aerobic gram na-adịghị mma: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis.

Ọrịa ndị na-esote nwere ike ibuso Augmentin CP naanị na vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, prọonia, Streptococcus ndị na-amaghị nwoke, ndị na-amaghị nwoke na-agba ume, Enterococcus faecalis, Coryneococcocpoccus peptes.

nje aerobic gram na-adịghị mma (gụnyere ụdị beta-lactamase na-amịpụta): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseria gemoriöfeiserererererererrina ), Campylobacter jejuni,

nje anaerobic gram na-adịghị mma (gụnyere ụdị na-emepụta beta-lactamases): Bacteroides spp., gụnyere Bacteroides fragilis.

Clavulanic acid dị na Augmentin CP na-egbochi ụdị II, III, IV na V nke beta-lactamases, arụghị ọrụ megide ụdị I beta-lactamases, nke Pseudomonas aeruginosa mepụtara, Serratia spp., Acinetobacter spp. Clavulanic acid nwere tropism dị elu maka penisiliniin, n'ihi nke ọ na-etolite ogige nke nwere enzyme, nke na-egbochi mbibi enzymatic nke amoxicillin n'okpuru nduzi nke beta-lactamases.

Nsonaazụ

Site na usoro nri: ọgbụgbọ, vomiting, afọ ọsịsa, gastritis, stomatitis, glossitis, ụba ọrụ nke transminases "imeju", n'ọnọdụ ndị dịkarịsịrị - cholestatic jaundice, ịba ọcha n'anya, imeju imeju (na-abụkarị ndị agadi, ụmụ nwoke, na ọgwụgwọ ogologo oge), pseudomembranous na hemorrhagic. colitis (nwekwara ike ịmalite mgbe ọ gwachara ọgwụ), enterocolitis, ire “ntutu ntutu” ojii, na-agba ọchịchịrị enamel ezé.

Ahụhụ Hematopoietic: mmụba mgbanwe nke prothrombin na oge ọbara ọgbụgba, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anaemia.

Site na sistemụ ụjọ: ọgbụgbọ, isi ọwụwa, hyperactivity, ụjọ, mgbanwe omume, nrị.

Mmeghachi omume mpaghara: n'ọnọdụ ụfọdụ, phlebitis na saịtị nke iv injection.

Ọrịa Allergic na-eme ka ihe ndị dị na Augmentin SR: urticaria, erythematous rashes, na-adịkarịghị - elektrik na-eme mkpesa, ụjọ anaphylactic, ụjọ na-adịghị ahụkebe, ọ na-eme ọfụma na - eme ka ọ bụrụ nke na-arịa ọrịa (Stevens-Johnson syndrome), ọrịa vasculitis, serum vasculitis. nnukwu juputara na oke pustulosis.

Ndị ọzọ: candidiasis, mmepe nke superinfection, nephritis interstitial, crystalluria, hematuria.

Ntụziaka pụrụ iche

Site na ọgwụgwọ Augmentin SR, ọ dị mkpa iji nyochaa ọnọdụ ọrụ ọbara, imeju na akụrụ.

Iji belata ihe egwu dị na nsị eriri afọ, a ga-eji ọgwụ a drugụọ ọgwụ ọgwụ.

Ọ ga-ekwe omume ịzụlite superinfection n'ihi mmụba nke microflora na-enweghị uche na ya, nke chọrọ mgbanwe kwekọrọ na ọgwụgwọ ọgwụ nje.

Enwere ike ịnye nsonaazụ ụgha na mkpebi nke glucose na mmamịrị. N'okwu a, a na-atụ aro iji usoro glucose oxidant maka ikpebi mkpokọ glucose na mmamịrị.

Mgbe dilution, ekwesịrị ịchekwa nkwụsị ahụ ihe na-erughị ụbọchị 7 na friji, mana ọ bụghị kpọnwụrụ.

N'ime ndị ọrịa nwere ọgwụ penicillins, mmeghachi omume nfụkasị na ọgwụ mgbochi cephalosporin ga-ekwe omume.

E kpughere okwu banyere mmepe nke ọrịa nje na ụmụ amụrụ ọhụrụ na ụmụ nwanyị dị ime nke mebiri emebi nke membranes.

Mmekorita

Ihe antacids, glucosamine, laxatives, aminoglycosides na-ebelata ma belata ntinye nke ihe ndị a na-akpọ Augmentin CP, ascorbic acid na-abawanye mmịpụta.

Ọgwụ bakteriostatic (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) nwere mmetụta antagonistic.

Na-abawanye arụmọrụ nke anticoagulants na-apụtaghị ìhè (na-egbochi microflora eriri afọ, na-ebelata njikọta vitamin K na ntanye prothrombin). Site na nhazi nke anticoagulants nke oge a, ọ dị mkpa iji nyochaa ndị na-egosi coagulability ọbara.

Na-ebelata ịdị irè nke mgbochi afọ, ọgwụ, n'oge metabolism nke etolite PABA, ethinyl estradiol - n'ihe ize ndụ nke ọbara ọgbụgba "ihe nkwụsịtụ".

Diuretics, allopurinol, phenylbutazone, NSAIDs na ọgwụ ndị ọzọ na-egbochi mmiri tubular na-eme ka mkpokọta amoxicillin nwee njikọ nke Augmentin SR (clavulanic acid bụ nke kachasị site na nzacha zuru ụwa ọnụ).

Allopurinol na - abawanye ohere ị nwere ịmalite ịrịa ọrịa akpụkpọ.

Ajụjụ, azịza, nyocha banyere ọgwụ Augmentin SR

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke kachasi banyere ogwu ahu di na ntuziaka nke ndi emeputaworo. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Mpempe mwepụta

A na-enweta Augmentin na mbadamba ihe mkpuchi fim, ntụ maka ọgwụ ntụtụ, yana ihe akọrọ maka ịda mmiri. A na-emepụta ntụ ntụ maka nkwadebe nke nkwụsị Augmentin na sirop. Analogues nke ọgwụ nwere otu ihe eji arụ ọrụ bụ: Amoxiclav, Bactoclav, Arlet, Klamosar.

Usoro onunu ogwu na nhazi

N'ikwekọ ntuziaka Augmentin ka akwadoro ka ị were tupu mmalite nke nri, a na-atụ aro ị individụ ọgwụ ahụ n'otu n'otu dabere na afọ onye ọrịa yana ogo ọrịa ahụ. Site na ọgwụgwọ, ọ ga - ekwe omume ịme usoro ọgwụgwọ - nke mbụ, a na - eji nchịkwa ọgwụ ọbara eme ihe, emesia ha gazie nchịkwa ọnụ. Usoro ọgwụgwọ ya na Augmentin anaghị agafe ụbọchị 14 na-enweghị ịmegharị foto ahụike. Maka ndị okenye na ụmụaka karịa afọ 12, a na-enye ya iwu maka ọrịa na-efe efe dị nro na obere 1 mbadamba 0.375 g ugboro atọ kwa ụbọchị, maka ọrịa siri ike 1 mbadamba 0.625 g ma ọ bụ mbadamba abụọ 0.375 g ugboro atọ n'ụbọchị. Site na nchịkwa intravenous, a na-ahapụ ya ka ọ jiri ọgwụ ahụ kwa awa 6 yana oke elekere kwa ụbọchị nke 7.2 g. Ndị ọrịa nwere ọrụ mgbazinye nsogbu n'oge ọgwụgwọ chọrọ mgbazi nke ọgwụ ọgwụ.

A na-enyekarị Augmentin maka ụmụaka na-erubeghị afọ 1 ụdị ọdịda. Ntụziaka ahụ gosipụtara na afọ ruru ọnwa atọ, otu usoro onunu ogwu bụ 0.75 ml, site na ọnwa atọ ruo ọnwa iri na abụọ - 1.25 ml. N'ihe banyere ọrịa siri ike na nchịkwa intravenous nke ọgwụ kwa awa 6-8, otu ọgwụ Augmentin maka ụmụaka site na ọnwa 3 ruo afọ iri na abụọ bụ 30 mg / n'arọ ahụ, ruo ọnwa 3 n'otu oge ahụ kwa awa 12 ọ bụla. Ọzọkwa, ụmụaka na-erubeghị afọ iri na abụọ ka a na-edebere nkwụchi nke Augmentin ma ọ bụ sirop. Dika ntuziaka ahu si di, umuaka site na onwa iteghete rue onwa abuo ka aburu 2.5 ml (0.156 g / 5 ml), site na onwa abuo rue asaa rue - 5 ml (0.156 g / 5 ml), site na 7 rue 12 - 10 ml (0.156 g / 5 ml) ugboro atọ n'ụbọchị, yana ọrịa siri ike, a na-ahapụ dose ahụ ka okpukpu abụọ.

Nkwado Augmentin kwadebere maka iji ya ozugbo iji ya, a na-agbaze ntụ ntụ n'ime mmiri esi mmiri na ụlọ okpomọkụ. A na-agbakwunye mmiri na akara akara na vial ahụ, ebe a na-eji nwayọ maa jijiji, wee dozie ya ruo mgbe ọ ga-agbaze kpamkpam n'ihe dị ka nkeji ise. Tupu i jiri nke ọ bụla, a ga-amata vial ya nke ọma, iji chọpụta etu usoro ọgwụgwọ ahụ dị, a na-eji okpu eji atụ ahụ, ejiri mmiri sachaa ya ma ọ were ya. A na-echekwa nkwanye ugwu dil na friji maka ihe na-erughị ụbọchị 7, mana anaghị ajụ oyi.

Ngwongwo ogwu

Fogwe aka

Ihe abuo nke Augmentin® SR (amoxicillin na clavulanic acid) na-agbachasị agbacha agbacha agbacha agbagha na ụkpụrụ physiological pH. Akụkụ abụọ a na-anabata ya ngwa ngwa yana nchịkwa ọnụ. Nnukwu ọkụ Augmentin® SR na-akawanye mma mgbe ewere ya na mbido nri.

Ọgwụ

Dose(mg)

T> MIC^ h(%)

Cmax (mg/l)

Tmax (h)

Auc

T1 / 2 (h)

Amoxicillin

Augmentin SR 1000 / 62.5 mg x 2

Clavulanate

Augmentin SR 1000 / 62.5 mg x 2

ND - akọwapụtaghị ya

T> oge MIC> kacha nta inhibitory ịta

Mkpokọta Mwepụta Augmentin Kwadoro® SR nwere profaịlụ pharmacokinetic / ọgwụ pharmacodynamic dị iche.

Ihe ngosi T> MIC nwetara mgbe ọ na-ede akwụkwọ ọgwụ Augmentin® SR dị iche na nke e nwetara site na otu usoro mbadamba nkume ndị ahụ na mwepụta nke bekee na-arụ ọrụ.

Mgbe a na-eji ọnụ ekwuo ya, a na-ahụ ọnya ọgwụgwọ nke amoxicillin na clavulanic acid na anụ ahụ na mmiri ọmụmụ. A na-achọta ọgwụgwọ nke ihe abụọ ahụ na eriri afọ, akwara nke eriri afọ, anụ ahụ, adipose na akwara ndị dị na ya, yana na ọgbụgba ume na peritoneal, bile na pus. Amoxicillin na clavulanic acid na-ejikọ aka na protein, ọmụmụ achọpụtala na ọgwụ mgbochi protein bụ 25% maka clavulanic acid yana 18% maka amoxicillin nke mkpokọta plasma ha. N'ime ọmụmụ anụmanụ, enweghị nchịkọta nke akụkụ ndị a na ngwa ọ bụla ka emebebeghị.

Enwere ike ịchọta Amoxicillin, dị ka penisilini ndị ọzọ, na mmiri ara. Enwere ike ịchọta uzo nke clavulanic acid na mmiri ara. Ọmụmụ banyere ọmụmụ ụmụ anụmanụ egosila na amoxicillin na clavulanic acid nwere ike ịgafe ihe mgbochi placental, mana enweghị ihe akaebe ọ bụla gbasara ọmụmụ ọmụmụ nwere nsogbu ma ọ bụ mmetụta ọjọọ na nwa ebu n'afọ.

A machibidoro Amoxicillin na mmamịrị n'ụdị Penicillinic acid na-adịghị arụ ọrụ na nha nke 10-25% nke were were. Clavulanic acid bụ metabolized n'ime ahụ mmadụ ruo 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid na 1-amino-4-hydroxy-butan-2-ma bụrụ nke a kpụrụ na ya. mmamịrị na feces, yana n'ụdị carbon dioxide nwere ikuku ekuru.

Amoxicillin bụ nke akụrụ ga - abụ nke akụrụ, ebe akwara clavulanic acid na - eme ka mkpụrụedị akụrụ na nke extrarenal. Ihe dịka 60-70% nke amoxicillin na ihe dịka 40-65% nke clavulanic acid bụ ndị a na-agbanwegharị na mmamịrị. Combinedjikọtara ya na probenecid na - egbochi ihe mmachi nke amoxicillin, mana ọ naghị egbu oge iwepụ akwara dị n'ime akụrụ ya.

O ghaghi imeghari udiri ogwu a.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Enweghị mkpa iji dozie dose nke ọgwụ ahụ na nwechapụ creatinine> 30 ml / min. N'ime ndị ọrịa nwere nhichapụ ihe na-erughị 30 ml / min, a naghị atụ aro ị takingụ ọgwụ ahụ.

Ọrịa ịba ọcha n'anya

Ndị ọrịa nwere ọria imeju

Jiri iji nlezianya mee ihe; data maka ịtụnye dosing ezughi ezu.

Mlọ ọgwụ

Augmentin® SR bụ ọgwụ nje nwere ọgwụ amoxicillin na clavulanic acid, nwere ọtụtụ nje nje, na-eguzogide ọgwụ beta-lactamase.

Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri ghara ịlụ ọgụ nke na - arụ ọrụ megide ọtụtụ microorganisms gram-positive na gram-gram-gram. A na-ebibi beta-lactamase ma ọ bụ na-emetụtaghị ụmụ nje ndị na-emepụta enzyme a.

Clavulanic acid bụ beta-lactamate, nke yiri ya na ihe owuwu mmiri na penisilini, nke nwere ike ime ka enzymes beta-lactamase nke microorganisms na-eguzogide ọgwụ penicillins na cephalosporins, si otú a na-egbochi irighiri mmiri nke amoxicillin. Karịsịa, ọ nwere nnukwu ọrụ megide plasmid beta-lactamases, nke ọgwụ nje na-ejikọkarị ya, mana ọ na-adịchaghị mma megide ụdị 1 chromosomal beta-lactamases.

Ọnụnọ nke clavulanic acid dị na Augmentin® SR na-echebe amoxicillin site na mmebi nke beta-lactamases ma na-agbasa ụdị dị iche iche nke ọrụ nje yana ntinye nke microorganisms nke na-eguzogide ọgwụ penicillins ndị ọzọ na cephalosporins ndị ọzọ. Clavulanic acid n'ụdị otu ọgwụ enweghị mmetụta ọgwụ nje dị egwu.

Usoro mmegide nguzogide

Clavulanic acid na-egbochi mmepe nke nguzogide nke enzymes beta-lactamase kpatara. Formdị nke ọgwụ ahụ na iji nwayọ nwayọ nke ihe ndị na-arụ ọrụ na-eme ka ịdị irè nke ọgwụ ahụ pụta megide microorganisms na iguzogide protein penicillin na-ejikọ.

Amoxicillin na-eme ka obelata mgbochi nke ọgwụ mgbochi beta-lactam ndị ọzọ, beta-lacamase inhibitors na cephalosporins.

Ka Augmentin®SrIhe ndị na-esonụ microorganism nwere mmetụta:

Airabes ọma Bacillius anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroids, Streptococcuska oyi baa†,

Ike pyogenes*†, Ikeptoptoccus agalactiae*†, Viridans otu streptococcus†, Ike spp. (ụdị β ọzọ nke hemolytic)*†, Staphylococcus aureus (na-eme ihe maka methicillin) *, Staphylococcus saprophyticus (chebara methicillin) Coagulase staphylococcus na-adịghị mma (methicillin mwute)

Gram-ọjọọ aerobes: Bordetella pertussis,Haemophilus na-efe efe *,

Haemophilus parainfluenzae,Helicobacter pylori,Moraxella catarrhalis *,

Neisseria gonorrhoeae,Pasteurella multocida,Ọrịa ịba

Borreliaburgdorferi,Leptospiraictterohaemorrhagiae,Treponema pallidum

Girata dị mma: Clostridium spp.,Peptococcus niger,Peptostreptococcus magnus,Ọkpụkpọ Peptostreptococcus,Peptostreptococcusspp.

Gram-ọjọọ anaerobes: Bacteroides fragilis,Bacteroides spp., Capnocytophaga spp., Eikenellacorrodens,Fusobacteriumnucleatum,Fusobacterium spp., Porphyromonas spp., Prevotellaspp.

Okike ndi nwere ike iguzogide

Corynebacterium spp., Enterococcus faecium

Gram odi njoikuku:Escherichia coli *, Klebsiella oxytoca, Klebsiella pneumoniae *, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Microorganisms nwere nguzogide sitere n'okike:

Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei,Legionella pneumophila,Morganella morganii,Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomas maltophilia,Yersinia enterolitica

Chlamydia ka oyi baa, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

* Egosipụta ịdị irè na ọnwụnwa nke ụlọ ọgwụ.

Micro microorganisms ndị na-emeghị beta-lactamase

Usoro onunu ogwu na nhazi

Ekwesịrị iji Augmentin® SR dabere na ntuziaka gọọmentị mpaghara maka ọgwụ ọgwụ eji eme ihe, yana data mpaghara gbasara ike ị drugụ ọgwụ.

Augmentin® SR bu n’obi maka ọgwụgwọ obere oge nke ọrịa nje nke microorganisms nke maara ọgwụ ahụ.

Nkwado na Augmentin® SR dịgasị iche site na mpaghara ala na oge. Ọ dị mkpa ịmụ data mpaghara gbasara ọghọm dị n'ọgwụ ahụ, yana, ọ bụrụ na ọ ga-ekwe omume, were akwụkwọ ahụ ma duzie nyocha ya.

Iji mee ka mmụba Augmentin dịkwuo elu® A na-atụ aro ka ebute SR na mmalite nri. Agaghị aga n'ihu ọgwụgwọ karịa ụbọchị 14 na-enweghị nyochagharị ọnọdụ onye ọrịa ahụ.

Erere Augmentin® SR nwere uzo na-ekewa, na-enye ha ohere imebi na ọkara maka ngbako iru ala, mana obughi ibelata ogwu a: aghaghi abuo abuo n’otu oge.

Usoro akwadoro bụ mbadamba abụọ ugboro abụọ n'ụbọchị.

Ndị okenye na ndị nọ n'afọ iri na ụma (afọ 16 na okenye))

Mbadamba mbadamba abụọ ugboro abụọ n’ụbọchị asaa ruo ụbọchị iri

Anwụ nke bronchitis na-adịghị ala ala

Mbadamba mbadamba abụọ ugboro abụọ ụbọchị asaa

Ọrịa jisiri na-akpata nnukwu ọrịa

Mbadamba mbadamba abụọ ugboro abụọ n'ụbọchị iri

Mgbochi ọrịa nje na-efe efe na mpaghara ịwa ahụ

Mbadamba mbadamba abụọ ugboro abụọ n'ụbọchị maka ụbọchị 5, ibido ịmalite kwesịrị ịbụ awa 3 mgbe ịwa ahụ gachara

Ezubere ụdị usoro ọgwụgwọ a maka ụmụaka na-erubeghị afọ 16.

Belata Augmentin Dose® SR ekwesighi, onunu ogwu a bu nke ndi okenye.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Enweghị mkpa iji dozie dose nke ọgwụ ahụ na nwechapụ creatinine> 30 ml / min. N'ime ndị ọrịa nwere nhichapụ ihe na-erughị 30 ml / min, a naghị atụ aro ị takingụ ọgwụ ahụ.

Ọrịa ịba ọcha n'anya

Ndị ọrịa nwere ọria imeju

Iji jiri nlezianya mee ihe, ọ dị mkpa iji nyochaa ọrụ hepatic n'oge oge niile. Enweghi data zuru ezu iji kwado dosing.

Dodoụbiga ya ókè

Ọrịa eriri afọ na mgbakasị ahụ na nguzo mmiri-electrolyte ga-ekwe omume. A kọwara amoxicillin crystalluria, n'ọnọdụ ụfọdụ na-eduga na mmepe nke ọdịda akwara.

Ọgwụgwọ: symptomatic ọgwụgwọ, mgbazi nke mmiri-electrolyte itule. Aha ya bụ Augmentin® A na-ewepụ SR site n'ọbara site na mmegharị ahụ.

Mpempe akwụkwọ Mpempe akwụkwọ

Laboratoire GlaxoSmithKline, France

(100, okporo ụzọ de Versailles, 78163 Marly-Le-Roi, Cedex)

Adreesị nke nzukọ ahụ na-anabata ihe ndị na-azụ ahịa na-ekwu maka ịdị mma nke ngwaahịa (ngwongwo) na Republic of Kazakhstan

Representativelọ ọrụ nnọchite anya GlaxoSmith Klein Export Ltd na Kazakhstan 050059, Almaty, st. Furmanova, 273

Nọmba ekwentị: +7 727 258 28 92, +7 727 259 09 96

Ihe onyonyo 3D

Mlọ ọgwụ

Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri dị nro dị n'ọtụtụ ọgụ na -emegide ọtụtụ gram-positive na gram-microorganisms. N'otu oge ahụ, amoxicillin nwere ike ibute mbibi site na beta-lactamases, yabụ kwa ụdị ọrụ nke amoxicillin anaghị erute microorganisms nke na-emepụta enzyme a.

Clavulanic acid, ihe dị na beta-lactamase inhibitor n'ihe metụtara penisilini, nwere ike ịhapụ ịgbatị ọtụtụ beta-lactamases ndị a hụrụ na penisilini na cephalosporin na-eguzogide ọgwụ. Clavulanic acid na-arụ ọrụ nke ọma megide plasmid beta-lactamases, nke na-abụkarị maka nje na-eguzogide ọgwụ, ọ nweghịkwa arụ ọrụ megide chromosomal beta-lactamases nke ụdị nke 1st, nke clavulanic acid na-egbochi.

Ọnụnọ nke clavulanic acid dị na nkwadebe Augmentin protects na-echebe amoxicillin site na mbibi site na enzymes - beta-lactamases, nke na-enye ohere ịgbasa ụdị nje antibacterial nke amoxicillin.

Ntọhapụ nwayọ nke amoxicillin na nkwupute Augmentin ® SR na-enye ohere ijigide ịdị ọcha nke ụdị ndị ahụ S. oyi baanke nguzogide amoxicillin sitere na protein ndi na-ekegide penicillin S. oyi baa, ma ọ bụ PRSP).

Ihe ndị a bụ ọrụ nke ngwakọta nke amoxicillin na clavulanic acid in vitro.

Nje bacteria na-agbakarị ọgwụ ma ọ bụ ngwakọta nke amoxicillin na clavulanic acid

Airabes ọma Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pneumoniae 1,2, Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, otu na - arụ ọrụ Viridans 2, Streptococcus spp. (beta ọzọ hemolytic streptococci) 1,2, Staphylococcus aureus (chebara methicillin) 1, Staphylococcus saprophyticus (na-emetụta methicillin), coagulase-sta staloloccci (na-emetụta methicillin).

Gram-ọjọọ aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Ndị ọzọ: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Girata dị mma: Clostr> gụnyere Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros.

Gram-ọjọọ anaerobes: Bactero> gụnyere Bactero> gụnyere Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Nje nke bu nje nke nwetara ihe ojoo na nchikota amoxicillin na clavulanic acid nwere ike idi

Gram-ọjọọ aerobes: Escherichia coli 1, Klebsiella spp., gụnyere Klebsiella oxytoca, Klebsiella poniaoniae 1, Proteus spp., gụnyere Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Airabes ọma Corynebacterium spp., Enterococcus faecium.

Nje bacteria na -eche na -echeta njikọta nke amoxicillin na clavulanic acid

Gram-ọjọọ aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Ndị ọzọ: Chlamydia spp.,. gụnyere Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 E gosipụtara ụdị microorganism dị iche iche, arụmọrụ nke akụrụngwa nke ngwakọta nke amoxicillin na clavulanic acid n'ọmụmụ nyocha.

2 Usoro nje nke ụdị nje a anaghị arụpụta beta-lactamases. Ihe mmetụta uche na amoxicillin monotherapy na-atụ aro inwe uche yiri nke ahụ na nchikota nke amoxicillin na clavulanic acid.

Nguzogide obe. Amoxicillin gosipụtara mgbochi nguzogide na ọgwụ mgbochi beta-lactam ndị ọzọ, yana ngwakọta nke ọgwụ mgbochi beta-lactam na inhibitors beta-lactamase na cephalosporins.

Zọ nguzogide. Clavulanic acid na-echebe amoxicillin site na mmebi nke beta-lactamases. Releasehapụ ngwa ngwa ọgwụ ọgwụ Augmentin ® SR na-abawanye arụmọrụ nke amoxicillin megide microorganisms onye nguzogide ya bụ n'ihi mgbanwe nke penicillin na-ejikọ.

Mlọ ọgwụ

Ngwakọta ọrụ abụọ nke Augmentin ® SR, amoxicillin na clavulanic acid, na-agwakọta nke ọma na ngwọta mmiri na-eji ọgwụ physiological pH, ma na-enweta ngwa ngwa na kpamkpam site na eriri afọ mgbe nchịkwa ọnụ. Orhapụ ọgwụ ndị dị ike bụ ihe dị mma ma ọ bụrụ na ị takingụ ọgwụ ọjọọ ahụ na mmalite nri.

N'okpuru ebe a bụ ọgwụ ọgwụ ọgwụ kemioxillin na acid a na-etinye ọgwụ mbadamba ụrọ. Augmentin ® SR nke ndị ọrụ afọ ofufo mara mma na mmalite nri.

Nkezi ọgwụ pharmacokinetic

Clavulanic acid