Amaril ma ọ bụ Ọrịa mamịrị: nke ka mma na Russian analogues?

N'ihi ọnụ ahịa Amaril dị elu, a na-eji analogues eme ihe ugboro ugboro iji mee ka glucose ọbara dị na ndị ọrịa mamịrị nwere ụdị ọrịa na-enweghị insulin. Ọgwụ a dị mma maka ijikwa glycemia na nri pụrụ iche na egwuregwu.

Agbanyeghị, ọ bụghị onye ọ bụla nwere ike ị nweta ego nke hypoglycemic a. Ya mere, n'isiokwu a, a ga-ekpughe ọgwụ ọgwụ nke Amaril na aha analogues nke bụ isi na Russia.

Emere ọgwụ ọgwụ

Amaryl bụ ọgwụ hypoglycemic nke na-enyere obere shuga ọbara aka site na-akpali ntọhapụ na mmegharị nke insulin njikọta site na mkpụrụ ndụ beta akọwapụtara dị na anụ ahụ.

Mainzọ kachasị eji arụ ọrụ na-akpali akpali bụ na Amaril na-eme ka ịbawanye uru nke sel beta na-abawanye na glucose n'ọbara mmadụ.

Na obere doses, ọgwụ a na-eme ka ntakịrị mmụba na ntọhapụ nke insulin. Amaryl nwere ikike ime ka mmetụta nke ihe ndị mejupụtara insulin na-akpata n’ime insulin.

N'ịbụ onye sitere na usoro ọgwụ sulfonylurea, Amaril nwere ike imetụta usoro nke mmepụta insulin. A na - eme ka nke a sie ike site na eziokwu na oke ọgwụ a na - arụ ọrụ na - eso ụzọ ATP nke sel beta na - emekọrịta ihe. Amaryl na - ekekọta ihe ndi na - edozi aru n’elu akwa akpụkpọ ahụ. Ngwongwo ọgwụ a na-enye ohere ịbawanye uru nke akwara anụ ahụ na insulin.

Ọkpụkpụ glucose na-abanye n’ime mkpụrụ ndụ akwara nke anụ ahụ.

Na mgbakwunye, iji ọgwụ ahụ na-egbochi mwepụta glucose site na sel nke akwara nke imeju. Usoro a na - eme n'ihi mmụba nke ọdịnaya nke fructose-2,6-biophosphate, nke na - enyere aka na mgbochi nke gluconeogenesis.

Ationme ka insulin njikọta rụpụta ihe n'ihi eziokwu ahụ bụ na ihe na - arụ ọrụ nke ọgwụ ahụ na - akwalite nsị nke ion potassium n'ime sel beta, yana ịba ụba nke potassium n'ime sel na - eduga n'ịba ụba nke homonụ.

Mgbe ị na-eji usoro ọgwụgwọ na ngwakọta na metformin, ndị ọrịa na-enwe ọganihu na metabolic na-achịkwa ọkwa shuga n'ime ahụ.

Na-eduzi usoro ọgwụgwọ ọgwụgwọ yana injections insulin. A na-eji usoro nchịkwa a mee ihe n'ọnọdụ ebe ogo adịghị ike nke metabolic na-adịghị enweta mgbe ị na-ewere otu ọgwụ. Mgbe ị na-eme ụdị ọgwụ a maka ọrịa shuga mellitus, a chọrọ ọgwụ mmachi insulin nke insulin.

A na-eme ka ego nke insulin ji na ụdị ọgwụgwọ a belata.

Pharmacokinetics nke ọgwụ

Site na otu ọgwụ ọgwụ kwa ụbọchị kwa 4 mg, a na-ahụkarị nsonaazụ ya mgbe elekere 2.5 gachara, ọ bụ 309 ng / ml. Bi ndu nke ogwu ahu bu 100%. Nri adighi enwe otu uzo esi abanye na mmiri, ma ewepu obere osiso na osiso nke usoro a.

Ihe eji aru oru eji eme ihe bu ihe eji eme ka aru banye n’ime mejuputara nke mmiri ara. Kedu nke na - egbochi ohere ị theụ ọgwụ n’oge afọ ime na inye nwa ara.

A na-eme metabolism nke ihe na-arụ ọrụ na akwara nke imeju. Isi isoenzyme tinyere aka na metabolism bụ CYP2C9.Na usoro nke metabolism nke kọmpụta nke bụ isi na-arụ ọrụ, etolite metabolites abụọ, nke na-esochi na feces na mmamịrị.

Ewepụta ọgwụ ahụ site akụrụ na oke 58% na ihe dịka 35% site na enyemaka nke eriri afọ. Achọpụtaghị ihe dị n'ọrụ ọgwụ ahụ na mmamịrị anaghị agbanwe agbanwe.

Dabere na nsonaazụ nke ọmụmụ a, achọtara na ọgwụ ọgwụ anaghị adabere na nwoke ma ọ bụ nwanyị na ọgbọ ya.

Ọ bụrụ na onye ọrịa enweela nsogbu akụrụ na usoro ịtụrụ ụjọ, onye ọrịa nwere mmụba nke glimepiride yana mbelata mgbanye ya n'ọbara, nke a na-ebute ngwa ngwa iwepụ ọgwụ ahụ n'ihi ntakịrị njikọta nke ihe arụ ọrụ yana protein.

Njirimara nke ọgwụ a

Ihe Amaryl ka atughariri n’ọbara nke atọ emere nye ihe eji eme ihe. Mba ndị mepụtara ọgwụ ahụ bụ Germany na Italytali. Emere ọgwụ a n'ụdị mbadamba na 1, 2, 3 ma ọ bụ 4 mg. Otu mbadamba 1 nke Amaril nwere ihe mejuputara - glimepiride na ndi ozo.

Nsonaazụ nke glimepiride bụ ebumnuche ịbelata glucose ọbara site na mkpali imepụta insulin site na mkpụrụ ndụ beta. Na mgbakwunye, ihe na-arụ ọrụ nwere mmetụta insulinomimetic ma na-eme ka ọgụgụ isi nke ndị na-anabata mkpụrụ ndụ nwee ume na homonụ na-ebelata sugar.

Mgbe onye ọrịa ahụ na-ekwu okwu Amaryl, a na-enweta ntinye akwụkwọ kachasị elu nke glimepiride mgbe awa 2.5 gachara. Enwere ike ị medicineụ ọgwụ n’agbanyeghi oge iri nri. Agbanyeghị, iri obere nri na-emetụta ọrụ glimepiride. N'ụzọ bụ isi, a na - ewepụta ihe dị na ahụ site na eriri afọ na akụrụ.

Ọkachamara na-ahụ maka ọgwụgwọ na-enye onye ọrịa nwere ụdị shuga nke 2 ọgwụ Amaril mbadamba dị ka monotherapy ma ọ bụ mgbe ejikọtara ya na ndị ọrụ hypoglycemic.

Agbanyeghị, ị theụ ọgwụ ahụ anaghị egbochi ọfụma na nri kwesịrị ekwesị, nke na-ewepụ abụba na carbohydrates dị mfe, na ndụ dị gara gara.

Ntuziaka maka iji ọgwụ ahụ

Nweghị ike ịzụta ọgwụ n’enweghị ọgwụ dọkịta. Tupu iji ọgwụ ahụ, ị ga-agarịrị dọkịta ma jụọ ya ajụjụ gị niile. Ọ bụ ya bụ onye nwere ike ikpebi etu ogwu a si wee nye gị ọgwụ usoro ọgwụgwọ dabere na glucose onye ọrịa.

Ana ewere mbadamba amaryl nke edere edere, n’achoghi ya, ma jiri mmiri zuru ezu sachaa ya. Ọ bụrụ na onye ọrịa chefuru ị drinkụ ọgwụ ahụ, a machibidoro ya ugboro abụọ. N'oge ọgwụgwọ, ịkwesịrị ịlele ọkwa shuga oge niile, yana ịta nke gemocololated hemoglobin.

Na mbido, onye ọrịa na-a doseụ otu ọgwụ nke 1 mg kwa ụbọchị. Nke nta nke nta, na oge nke otu ruo izu abụọ, usoro ị ofụ ọgwụ ahụ nwere ike ịbawanye site na 1 mg. Dịka ọmụmaatụ, 1 mg, mgbe ahụ 2 mg, 3 mg, na ndị ọzọ na- 8 mg kwa ụbọchị.

Ndị ọrịa mamịrị nwere ezigbo glycemic na-a takeụ ọgwụ kwa ụbọchị nke ruru 4 mg.

Ọtụtụ mgbe, a na-a theụ ọgwụ ahụ otu ugboro tupu nri ụtụtụ ma ọ bụ, ọ bụrụ na ịmebie aha mbadamba, tupu isi nri. N'okwu a, ọkachamara ahụ ga-eburu n'uche ụdị ndụ nke ndị ọrịa mamịrị, oge nri ya na mmega ahụ ya. Imezi ọgwụ ahụ nwere ike ịdị mkpa mgbe:

mbelata ibu
gbanwee ụdị ndụ (nri, nrụgide, oge nri),
ihe ndi ozo.

Ọ dị mkpa ịgakwuru dọkịta ma malite na obere opekempe (1 mg) nke Amaril ma ọ bụrụ na onye ọrịa chọrọ:

dochie ọgwụ ọzọ eji eme ka shuga dị na Amaril,
Nchikota glimepiride na metformin,
Nchikota bu glimepiride na insulin.

Ọ baghị uru ị medicineụ ọgwụ maka ndị ọrịa nwere ọrịa gbasara akụrụ, yana ọrịa akụrụ na / ma ọ bụ ọrịa imeju.

Njere uto na mmeghachi omume ojoo

Amaril glimepiride dị na ọgwụ ahụ, yana akụkụ ndị ọzọ, anaghị enwe mmetụta dị mma mgbe niile n'ahụ ahụ onye ọrịa mamịrị.

Aszọ ndị ọzọ, ọgwụ nwere contraindications.

Amachibidoro ndị ọrịa ị pụ ọgwụ na ọnọdụ ndị a:

ofdị shuga insulin
oge ime na ara,
ọrịa shuga (ketoacidosis) nke akpịrị na-arịa ọrịa shuga (shuga na-arịa ọrịa shuga).
ndị ọrịa na-erubeghị afọ 18,
ụyọkọ galactose, ụkọ lactase,
mmepe nke glucose-galactose malabsorption,
imebi imeju na akụrụ, ọkachasị ndị ọrịa na-ele ịba ọcha n'anya.
mmadu anagideghi ihe di n’ime ogwu ahu, nkari sulfonylurea, ndi na acho sulfonamide.

Ntụziaka ejikọtara na-ekwu na n'ime izu mbụ nke ọgwụgwọ, ekwesịrị ịkpachara anya Amaryl iji zere mmepe nke ọnọdụ hypoglycemic. Na mgbakwunye, n'ihe banyere malabsorption nke nri na ọgwụ site na nri diges, ụkọ glucose-6-phosphate dehydrogenase, ọrịa na-efe efe, yana ọnụnọ nke ịmalite hypoglycemic steeti, a na-eji Amaril akpachapụ anya.

Site n'iji mbadamba eme ihe na-ekwesịghị ekwesị (dịka ọmụmaatụ, nnabata), mmeghachi omume siri ike nwere ike ịmalite:

Ọnọdụ hypoglycemic, akara nke ya bụ isi ọwụwa na nkụda mmụọ, ntị na-adịghị mma, oke iwe, ọgba aghara, ụra, ụjọ na-atụ, mkpọtụ, na ọhụhụ.
Usoro nchịkwa mgbochi nke Adrenergic dị ka nzaghachi maka mgbali glucose ngwa ngwa, gosipụtara nchekasị, palpitations, tachycardia, ọgba aghara nke obi na ọdịdị nke ọsụsọ oyi.
Ọgba aghara digestive - mkpọchi ọgbụgbọ, ọgbụgbọ, flatulence, abdominal pain, afọ ọsịsa, mmepe nke ịba ọcha n'anya, ụba ọrụ enzymes imeju, jaundice or cholestasis.
Mmebi nke usoro hematopoietic - leukopenia, thrombocytopenia, granulocytopenia na ụfọdụ ọrịa ndị ọzọ.
Allergy, gosipụtara site na rashes akpụkpọ, itching, hives, mgbe ụfọdụ anaphylactic ujo na vasculitis nfụkasị.

Mmeghachi omume ndị ọzọ ga - ekwe omume - photoensitization na hyponatremia.

Efu, nyocha na analogues

Ọnụahịa ọgwụ Amaryl na-adabere kpọmkwem n'ụdị ntọhapụ ya. Ebe ọ bụ na ebubata ọgwụ ahụ, yabụ, ọnụ ahịa ya dị elu. Ọnụ ego ọnụahịa nke mbadamba Amaryl bụ ndị a.

1 mg 30 mbadamba - 370 rub.,
2 mg 30 mbadamba nkume - 775 rubles.,.
3 mg 30 mbadamba - 1098 rub.,
4 mg 30 mbadamba nkume - 1540 rub.,

Banyere echiche nke ndị ọrịa mamịrị banyere ịdị irè nke ọgwụ, ha dị mma. Site na iji ọgwụ ogologo oge, ọkwa glucose na-alaghachi na nkịtị. Ọ bụ ezie na ndepụta ahụ nwere ọtụtụ nsonaazụ ndị ọ ga-ekwe omume, pasent nke ihe omume ha dị obere. Agbanyeghị, enwere nyocha ndị na-adịghị mma gbasara ndị ọrịa metụtara ọnụ ahịa ọgwụ dị elu. Ọtụtụ n'ime ha ga-achọ nnọchi ndị Amaril.

N'ezie, ọgwụ a nwere ọtụtụ okwu na analogues mepụtara na Russian Federation, dịka ọmụmaatụ:

Glimepiride bụ ọgwụ nwere otu arụ ọrụ, contraindications na nsonaazụ ndị ọzọ. Ihe dị iche bụ naanị na ọgwụ ndị ọzọ. Ọnụ ego ọgwụ ahụ (2 mg Nke 30) bụ 189 rubles.
Diagninide bụ ọgwụ na-ebelata shuga, n'ụdị ya yiri ọgwụ a na-ebubata NovoNorm. Ihe na-arụ ọrụ bụ reaglinide. Novonorm (Diagninide) nwere otu ụdị contraindications na mmeghachi omume na-adịghị mma. Iji ghọta nke ọma ihe dị iche iche na analogues abụọ a, ọ dị mkpa iji tụnyere ọnụahịa: ọnụahịa nke Diaglinide (1 mg Nke 30) bụ 209 rubles, na NovoNorm (1 mg Nke 30) bụ 158 rubles.
Glidiab bụ ọgwụ Russia bụkwa nke dokwara anya maka ọrịa mamellitus Diabeton nke ama ama.Nkezi ego Glidiab mbadamba (80 mg Nke 60) bu 130 rubles, na onu ahia ogwu Diabeton (30 mg Nke 60) bu 290 rubles.

Amaryl bụ ezigbo shuga na-ebelata ọgwụ shuga, mana ọnụ. Ya mere, enwere ike dochie ya na ọnụ ala, ma ụlọ (Diclinid, Glidiab), yana ọgwụ dị mbubata (NovoNorm, Diabeton). Ihe mejupụtara ya nwere ma glimepiride, ma ọ bụ ihe ndị ọzọ na-eme ka mbelata glucose. Knowingmara banyere analogues, dọkịta na onye ọrịa ahụ ga-ekpebi ọgwụ dị mma ị ga-ewere. Vidiyo dị na isiokwu a na-aga n'ihu na isiokwu nke Amaril maka ọrịa shuga.

Amaril - ntuziaka maka ojiji nke ịgwọ ọrịa shuga, usoro nke ime ihe, contraindications na nyocha

Ọrịa shuga 2dị nke Abụọ bụ ọrịa dị ize ndụ nke na-ebukarị n’afọ ndị karịrị 40 na-enwekarị oke ibu.

Mbelata uche nke anụ ahụ na insulin, yana mbelata nke akụrụngwa nke pancreatic, na-eduga na ọ dị mkpa maka ọgwụgwọ ọgwụ na glimepiride.

Ọgwụ dị irè bụ Amaril, nke nwere ike belata iji glucose na-eji obere nsogbu nke nsonaazụ dị ala.

Ọgwụ a bụ nke ndị ụlọ ọgwụ na ọgwụ ọgwụ nke ọgwụ hypoglycemic ọgwụ nke n'ọbara nke atọ n'ọbara. Amaryl nwere ọrụ ogologo oge.

Nchikota ya, ya na isi ihe nke antioxidant action na obere ihe na akwara nke obi, butere otutu ogwu a iji buso oria nke abuo n’anaghi aru nke metformin monotherapy.

A gosipụtara ọgwụ a n'ahịa n'ọtụtụ ụdị ntọhapụ anọ dị iche iche, nke ọ bụla n'ime ha bụ maka ịgwọ ọrịa shuga, dabere na njirimara onye ọrịa ahụ:

Amaril, 1 mg: mbadamba uhie pink nke odidi dị larịị, n’akụkụ abụọ enwere ihe nkerisi, leta "h" na ihe osise "NMK".
Amaril, 2 mg: mbadamba akwụkwọ ndụ akwụkwọ ndụ na-acha edo edo, nke dị larịị, n'akụkụ abụọ enwere ihe nkerisi, leta "h" na ihe osise "NMM".
Amaril, 3 mg: mbadamba uhie edo na-acha odo odo bụ mbadamba akwụkwọ dị larịị, n'akụkụ abụọ, enwere ihe nkerisi nkewa, leta "h" na ihe osise "NMN".
Amaril, 4 mg: mbadamba anụnụ anụnụ na-acha anụnụ anụnụ, nke dị larịị, n'akụkụ abụọ enwere ihe mgbawa nkewa, leta "h" na ihe osise "NMO".

Ihe eji arụ ọrụ	Ngwa ihe inyeaka
Glimepiride	lactose monohydrate, sodium carboxymethyl stachi, povidone, microcrystalline cellulose, magnesium stearate, ọbara ọbara na-acha uhie uhie na ọla edo na-acha odo odo, indigo carmine

Ọgwụ a bụ otu nke ọgwụ hypoglycemic sitere na ụdị nke sulfonylurea. Akụkụ ike nke Amaril na-arụ ọrụ na-eme ka nsonaazụ insulin si na mkpụrụ ndụ akwara pụta.

Ihe omume a bụ ike nke ọgwụ iji mee ka uche nke ihe n’akpata ume mkpali.

Tinyere mmetụta akọwapụtara, Amaril nwere ikike nke ime ihe na-eme ka a na-eme ya ma na-eme ka ọgụgụ anụ dị na insulin. Glimepiride na-eme ka mwepu glucose na umeji kwụsị.

Ntinye uche kachasị na ọbara ọbara mgbe ị isụsịrị 4 mg nke ọgwụ a ka ọ gachara awa 2.5. Bioavailability nke ihe eji arụ ọrụ arụ ọrụ bụ 100%.

Amarchịkọta Amaril na nri nke ọma anaghị emetụta ogo nnabata yana ọkwa glucose metabolism. Glimepiride nwere ike imeri ihe mgbochi placental ma banye nke mejupụtara ara mmiri ara.

Metabolism nke ọgwụ na-aputa n'ime imeju site na nguzobe nke metabolites na-abanye na feces (35%) na mmamịrị (58%).

Ihe ngosi maka ojiji

A na-eji Amaril mee ihe nke ọma na ọgwụgwọ nke ndị okenye okenye na-arịa ọrịa shuga 2 na-enweghị mkpa monotherapy na insulin.Edere ụzọ nlekọta ọrụ n'ọnọdụ ebe enweghị ike idobe mkpokọta glucose na ọbara na ọkwa nchekwa naanị site na enyemaka nke mmega ahụ, ịtalata oke yana nri pụrụ iche.

A na-ewere Amaryl n'oge nri ma ọ bụ tupu nri, ejiri mmiri mmiri sachaa ya. Na ọkwa mbụ nnabata, enwere ihe ize ndụ nke hypoglycemia, yabụ njikwa dọkịta dị mkpa. A na-ekpebi ọ̀gwụ nke glimepiride site na nsonaazụ nke ikpebi ọkwa shuga na mmamịrị na ọbara.

N'ikuku amalite n'otu mbadamba (1 mg glimepiride) kwa ụbọchị. Ọzọkwa, mgbe a na-achọpụta ụkọ nchịkwa glycemic, usoro onunu ogwu ahụ ruru 2 mg ma ọ bụ karịa. Oge dị n’etiti ịrị elu bụ izu 1-2. Oke kachasị bụ 6 mg kwa ụbọchị.

Ọ bụ naanị dọkịta ka ọ gụrụ ọgwụ insulin.

Mmanya na Amaryl

Ọgwụ nwere mmetụta kpọmkwem na shuga ọbara. A na-eme ihe omume a na mgbazi ọzọ dị ukwuu n'okpuru mmetụta nke mmanya. Mmetụta hypoglycemic nwere ike ịbawanye ma ọ bụ belata, ọ na-esikwa ike ịkọ mmetụta a gosipụtara, nke na-eduga mmachibido ị onụ mmanya na-aba n'anya mgbe ị na-a theụ ọgwụ ahụ.

Mkparịta ụka ọgwụ ọjọọ

N'ihi metabolism nke ihe na-arụ ọrụ n'ime imeju, akpachara anya kwesịrị itinye aka na ijikọta ọgwụ ahụ na ndị indurs ma ọ bụ ndị na-egbochi cytochrome isoenzymes (Rifampicin, Fluconazole). Mkparịta ụka ọgwụ ọjọọ glimepiride:

Insulin, hypoglycemic jami, steroids, chloramphenicol, ọgwụ coumarin, fibrates, quinolones, salicylates, sulfonamides, tetracyclines nwere ike hypoglycemic mmetụta nke ọgwụ ahụ, mụbaa ọrụ imeju na-arụ ọrụ na akụrụ ọrụ.
Barbiturates, glucocorticosteroids, diuretics, Epinephrine, laxatives, estrogens, ọgwụ nicotinic acid, homonụ thyroid na-ebelata ịdị irè nke ọgwụ.
Reserpine nwere ike belata ma nwekwuo mmetụta nke glimepiride.

Nsonaazụ

Na-emegide usoro ị takingụ ọgwụ ahụ, nsonaazụ akụkụ ya na akụkụ dị iche iche na sistemụ nwere ike ịmalite. Oge ụfọdụ gosipụtara gụnyere:

hypoglycemia (isi ọwụwa, nchekasị, oke iwe, nlebara anya, nkụda mmụọ, okwu na nhụsianya anya, nkwarụ, ọgbụgba, ọgbụgba, bradycardia, nsụhọ mmụọ),
oyi clammy ajirija
palpitations, ọrịa strok,
ọgbụgbọ, ọgbụgbọ, oke ibu na afọ, afọ ọsịsa, ịba ọcha n'anya, jaundice,
mụbara platelet, leukopenia, anaemia (mbelata ọbara), granulocytopenia, agranulocytosis,
Mmeghachi omume nfụkasị (itching, ihe ọkụ ọkụ, urticaria, urepula anflactic, vasculitis),
hyponatremia,
ndise

Dodoụbiga ya ókè

Ntuziaka maka iji Amaril dọọ aka ná ntị banyere ngosipụta nke mgbaàmà nke oke ịdoụbiga ihe ókè ma ọ bụ ọgwụgwọ ogologo oge na ọgwụ ahụ na oke doses n'ụdị nnukwu hypoglycemia. Enwere ike ịkwụsị ya ngwa ngwa site na iwere otu shuga, tii dị ụtọ, ihe ọ juiceụ .ụ.

Nnukwu ịdoụ ọgwụ ọ theụdoụ na-atụ ụjọ na nsụhọ, ọrịa akwara ozi. Na ịda mba, a na-edozi 40 ml nke 20% dextrose ma ọ bụ glucose na-eme ka mmadụ ghara ịdị na-eme ya, ma ọ bụ 0.5-1 mg nke glucagon ka a na-eme ya parenterally.

N'ụdị ndị ọzọ, a ga-achọ usoro ga -efochi eriri afọ, yana ikpo oku.

Anaarila Amarila

Ọgwụ ndị a na-eji dochie anya gụnyere ọgwụ sulfonylurea nke na-emegide ụdị shuga 2. Analogs nke n'aka:

Glimepiride - ọgwụ nwere otu aha,
Diagninide - ọgwụ na-ebelata okpukpo nke sitere na repaglinide,
NovoNorm - ọgwụ butere, na-agụnye ịkwụghachi azụ,
Glidiab - ọgwụ Russia dabere na glimepiride,
Ọrịa mamịrị bụ ọgwụ eji ebute shuga.

Amaril ma ọ bụ ndị ọrịa mamịrị - nke ka mma

Edere ọgwụ abụọ a maka ụdị ọrịa shuga dị n'ọkwa 2 dị na ụdị mbadamba.

Ha na-ahụ maka imepụta insulin, na-abawanye uru anụ ahụ, cholesterol dị ala na ihe na-egosi oge site na iri nri na ntọhapụ nke insulin.

Ọ bụrụ na onye ọrịa enweela nsogbu ọrụ akụrụ, ọgwụ na-agbadata ogo protein na mmamịrị. Ihe dị iche n'etiti ọgwụ bụ ọnụahịa - Diabeton dị ọnụ ala.

Ọnụahịa Amaril

Purchasezụta Amaril ga-efu ego dabere na ntinye uche nke ihe ndị na-arụ ọrụ, ọnụ ọgụgụ mbadamba ihe dị na ngwugwu yana amụma ọnụahịa nke ụlọ ọrụ na-ere ahịa. Na ọgwụ ọgwụ Moscow, ọnụ ahịa ọgwụ ga-abụ:

Drugdị ọgwụ	Ọnụahịa, rubles
Mbadamba 2 mg 30 pcs.	629
4 mg 90 pcs.	2874
1 mg 30 pcs.	330
4 mg 30 pcs.	1217
2 mg 90 pcs.	1743
3 mg 30 pcs.	929
3 mg 90 pcs.	2245

Enwere m ọrịa siri ike, dịkwa ize ndụ, ya mere aghaghị m iburu mbadamba Amaril maka ọrịa shuga 2. Mmasị mmetụta ha na ịdị mfe nke iji - otu mbadamba kwa ụbọchị. M na-a Diụ Diabeton, mana o mere m ihe ịzzụzzụ, na-arịa ọrịa mgbe mgbe. Site na ọgwụ a enweghi mmetụta dị otú a, mana ọ na-akwụ ụgwọ karịa. Ọ ga-aka amasị m ịkwụfe karịa anọgidesi ike.

Mama m nwere ọrịa shuga nke 2, ọ na-ewerekwa mbadamba Amaryl. Ọ na-a drugsụ ọgwụ dabere na ọgwụ nke metformin, mana ugbu a, ọ na-amanye ya ịgbanye ọgwụ ndị ka dị irè. O kwuru na ike ngwaahịa a na ọghọm ya. Mama m nwere obi ụtọ n'ọrụ ọgwụ ahụ, ọ na-ekwu na ọ na-ebelata shuga ọbara.

Anatoly, afọ 41

Enwere m ọrịa shuga, mana ọ nweghị ọgwụ insulin. Anyị kwesịrị iji ọgwụ pụrụ iche belata shuga ọbara. Ana m ewere Amaril maka na ọ bụ dọkịta gwara m ya. M na-a tabletsụ mbadamba na usoro nke 2 mg, mana m ga-agbanye na nke ịba ụba - mmụba nwayọọ nwayọọ na itinye uche na-enwe mmetụta ka mma na ahụike.

Ihe omuma a gosiputara n’isiokwu a bu ntuzi aka. Ngwa nke edemede ahụ anaghị akpọ maka ọgwụgwọ onwe. Naanị dọkịta ruru eru nwere ike ịchọpụta ọrịa ma nye ndụmọdụ maka ọgwụgwọ dabere na njirimara nke otu onye ọrịa.

Mbadamba amaryl - ntuziaka, nyocha nke onye ọbịa, ọnụahịa

Amaryl nwere glimepiride, nke bu ihe ohuru, nke ato, nke usoro ntinye nke sulfonylurea (PSM). Ogwu a di oke onu karia glibenclamide (Maninil) na glyclazide (Diabeton), mana ihe di iche n’onu ahia bu ihe ezi omume site na oru di elu, ngwa ngwa, uto di nfe na ekpom, na oria pere mpe na hypoglycemia.

Site na Amaril, sel beta nwere nwayọ nwayọ karịa n'ọgbọ gara aga nke sulfonylureas, yabụ na ọsụsọ nke ọrịa shuga na-agbadata ma ọ ga-achọ ọgwụgwọ insulin mgbe e mesịrị.

Nyocha ndị na-a theụ ọgwụ ahụ nwere nchekwube: ọ na-ebelata shuga nke ọma, ọ dabara adaba iji ya, na-a tabletsụ mbadamba otu ugboro n’ụbọchị, na-agbanyeghị ókè ọ na-a .ụ. Na mgbakwunye na glimepiride dị ọcha, a na-emepụta ngwakọta ya na metformin - Amaril M.

Ndewo Aha m bụ Galina, enweghịzi m ọrịa shuga! O were m naanị izu 3Ighaghachi shuga n’agha ma ghara iji ọgwụ ọjọọ na-enweghị ihe ọ bụla riri ya ahụ
>>Nwere ike gụọ akụkọ m ebe a.

Ntụziaka dị mkpirikpi

Ihe omume

Na-ebelata ọbara shuga, na-emetụta ọkwa ya n'akụkụ abụọ:

Na-akpali njikọ nke insulin, ma weghachite akụkụ mbụ, ngwa ngwa nke nzuzo ya. PSM ndị ọzọ fọdụrụnụ na -akwu oge a ma na-arụ ọrụ na nke abụọ, ya mere a na-ebelata shuga nwayọ nwayọ.
Na-ebelata insulin na-agbasi mbọ ike karịa PSM ndị ọzọ.

Na mgbakwunye, ọgwụ ahụ na-ebelata ihe ize ndụ nke thrombosis, na-eme cholesterol, ma na-ebelata nrụgide oxidative Amaryl na-ewepu akụkụ ụfọdụ na mmamịrị ahụ, akụkụ ya site na mgbaze nri, ya mere enwere ike iji ya na ndị ọrịa nwere akụrụ gbasara akwara, ma ọ bụrụ na echebere ọrụ akụrụ.Ihe na-egosiỌrịa shuga naanị ụdị 2. Ihe a ga-eji mee ihe bụ ichebe mkpụrụ ndụ beta, nke a na-ejikọkwa na insulin nke onwe ha.Ọ bụrụ na pancreas akwụsịla imepụta homonụ, ekwenyeghị Amaril. Dịka ntuziaka ahụ si dị, a pụrụ iji ọgwụ ọgwụ metformin na insulin gwọ ọgwụ ya.Usoro onunu ogwuA na-emepụta Amaryl n'ụdị mbadamba ụrọ nwere ihe ruru 4 mg nke glimepiride. Maka ịdị mfe nke iji ya, usoro ịsa ahụ ọ bụla nwere ụcha nke ya. A na-ewere ya ruo ụbọchị iri, mgbe nke a gasịrị, ha na-amalite nwayọọ nwayọọ ruo mgbe shuga na-ahazi. Ogwu a kacha anabata bụ 6 mg. Ọ bụrụ na ọ kwaghị ụgwọ nkwụghachi ụgwọ maka ọrịa shuga, a na-agbakwunye ọgwụ ndị sitere na otu ndị ọzọ ma ọ bụ insulin na usoro ọgwụgwọ.Dodoụbiga ya ókèExgabiga oke na-eduga na hypoglycemia dị ogologo. Mgbe usoro shuga kwusịrị, ọ nwere ike ịda ugboro ugboro maka ụbọchị 3 ọzọ. N'oge a niile, onye ọrịa ahụ kwesịrị ịnọ n'okpuru nlekọta nke ndị ikwu ya, ya na nnukwu ịdoụbiga mmanya ókè - ụlọ ọgwụ.Ihe ngbanwe

Hypersensitivity na-emeghachi omume na glimepiride na PSM ndị ọzọ, ihe inyeaka nke ọgwụ ahụ.
Enweghi insulin n'ime ahu (oria oria 1, oria puru iche).
Nnukwu gbasara akụrụ. Enwere ike ịnwe ọgwụ Amaril maka ọrịa akụrụ mgbe nyochachara akụkụ ahụ.
Glimepiride bụ metabolized na imeju, yabụ, imeju na-esonyekwa na ntuziaka ka contraindication.

Amaryl na-akwụsị nwa oge were were insulin injections n’oge ime na lactation, nnukwu nsogbu nke ọrịa shuga, site na ketoacidosis ruo hyperglycemic coma. Site na ọrịa na-efe efe, mmerụ ahụ, ịba ụba nke mmetụta uche, Amaril nwere ike ọ gaghị ezu iji mezie shuga, ya mere a na-agbakwunye ọgwụgwọ ahụ na insulin, na-adịkarị ogologo. Ewu nke hypoglycemiaỌbara shuga na-ada ma ọ bụrụ na onye na-arịa ọrịa shuga chefuru iri nri ma ọ bụ ghara itinyeghachi glucose ahụ a na-eme n’oge a na-emega ahụ́. Iji mezie glycemia, ị kwesịrị ị carbohydụ carbohydrates ngwa ngwa, ọ na-abụkarị obere shuga, iko mmiri ma ọ bụ tii dị ụtọ zuru ezu.Ọ bụrụ na ọnụọgụ nke Amaril agafe, hypoglycemia nwere ike ịlaghachi ọtụtụ oge n'oge ọgwụ. Na nke a, mgbe ha mechara shuga dị ka shuga, ha na-anwa wepu glimepiride na traktị nri: ha na-akpalite ọgbụgbọ, na-a adsụ adsorbents ma ọ bụ ọgwụ mgbu. Do overụbiga ihe ókè dị ukwuu na-egbu mmadụ; ịgwọ ọrịa hypoglycemia dị oké mkpa gụnyere glucose ọbara dị n’okpo ọbara. NsonaazụNa mgbakwunye na hypoglycemia, mgbe ị na-ewere Amaril, enwere ike ịhụ nsogbu mgbaze (n'ihe na-erughị 1% nke ndị ọrịa), nfụkasị ahụ, sitere na ihe ọkụ ọkụ na itching ruo ure anacticlactic (>gụọ akụkọ banyere Alla Viktorovna

Amaryl ma ọ bụ Glucophage

N’ikwu ya hoo haa, ajụrụ Amaril ma ọ bụ Glucofage (metformin) ekwesighi ekwenye. A na-edekarị Glucophage na analogues maka ụdị shuga 2 n'ụdị nke mbụ, ebe ọ bụ na ha na-arụ ọrụ karịa karịa ọgwụ ndị ọzọ na-eme ihe kpatara ọrịa ahụ - nguzogide insulin. Ọ bụrụ na dọkịta depụtara naanị mbadamba amaryl, ya ike kwesịrị obi abụọ.

N'agbanyeghị nchekwa nchekwa, ọgwụ a na - emetụta pancreas, nke pụtara na ọ na - ebelata njikọ insulin. Edere PSM naanị ma ọ bụrụ na anabataghị metformin ma ọ bụ na oke ya ezughi oke maka glycemia nkịtị. Dịka iwu, nke a bụ ma ọ bụ nnukwu orụ shuga, ma ọ bụ ọrịa ogologo oge.

Amaril na Yanumet

Yanumet, dị ka Amaryl, na-emetụta ma ọkwa insulin na nguzogide insulin. Ọgwụ dị iche iche na usoro eji arụ ọrụ yana usoro kemịkalụ, yabụ enwere ike ijikọ ha. Yanumet bụ ọgwụ ọhụụ, yabụ na ọ na-efu site na 1800 rubles. nke kacha nta mkpọ. Na Russia, edepụtara aha ya: Combogliz na Velmetia, nke adịghị ọnụ ala karịa nke mbụ.

N'ọtụtụ oge, enwere ike ị nweta ụgwọ ụgwọ ọrịa shuga site na nchikota metformin dị ọnụ ala, nri, mmega ahụ, mgbe ụfọdụ ndị ọrịa chọrọ PSM.Yanumet bara uru ịzụta naanị ma ọ bụrụ na ọnụ ahịa ya adịghị mkpa maka mmefu ego.

Ndị na - arịa ọrịa mamịrị na usoro ọgwụgwọ edepụtara bụ isi ihe kpatara mbelata ọrịa shuga.

Ibelata usoro ọgwụgwọ maka ọrịa ọ bụla na-adịghị ala ala na-eme ka nsonaazụ ya dị mma mgbe niile, ya mere, maka ndị ọrịa nhọrọ, a na-ahọrọ ọgwụ ngwakọta.

Amaryl M nwere ngwakọta kachasị eji ọgwụ belata shuga: metformin na PSM. Mbadamba ụrọ nke ọ bụla nwere 500 mg nke metformin na 2 mg nke glimepiride.

Ọ gaghị ekwe omume idozi ma ihe arụ ọrụ niile n'otu mbadamba maka ndị ọrịa dị iche iche. N'etiti n'etiti ọrịa shuga, metformin ọzọ, ọ nwere obere glimepiride chọrọ.

Anaghị anabata ihe karịrị 1000 mg nke metformin n'otu oge, ndị ọrịa nwere nnukwu ọrịa ga-a Amarụ mmanya Amaril M ugboro atọ n'ụbọchị.

Iji họrọ etu usoro ọgwụgwọ ahụ siri dị, ọ ga-adị mma ka ndị ọrịa dọọ aka na ntị were ọgwụ gaa Kalail iche iche na nri ụtụtụ na Glucofage ugboro atọ n'ụbọchị.

Maxim, dị afọ 56 tụgharịrị. Edebere Amaril nne m ka ọ bụrụ Glibenclamide iji wepu hypoglycemia ugboro ugboro. Ọgwụ ndị a na -ebelata shuga adịghị njọ karịa nke ahụ, ọ bụ ihe nwute na ọ bụ mmetụta ole na ole na ntuziaka ahụ, mana n'eziokwu enwereghị. Ugbu a ọ na - a mgụ ọgwụ 3, shuga na - ejide ihe dịka 7-8.

Anyị na-atụ egwu ịbelata ya karịa, ebe ọ bụ na nne dị afọ 80, ọ naghị enwekarị mmetụta nke hypoglycemia. Elena dị afọ iri anọ na anọ tụlere ya. Ọ bụ onye ọkà mmụta ọgwụ endocrinologist dere Amaril ma dọọ m aka na ntị ka m gaa ọgwụ German, ọ bụghị analogues dị ọnụ ala. Iji chekwaa, azụrụ m nnukwu ngwugwu, yabụ ọnụahịa na usoro 1 mbadamba 1 erughị. Enwere m ngwugwu zuru ezu ọnwa atọ.

Mbadamba ahụ dị obere, akwụkwọ ndụ akwụkwọ ndụ, nke nwere ụdị ọhụụ. A na-eme ọnya ahụ ọnụ, n'ihi ya, ọ dabara adaba iji kesaa ya n'ime akụkụ. Ntụziaka maka iji naanị nnukwu - peeji anọ dị na obere akwụkwọ ozi. Ọsụsọ na-ebu ọnụ bụ 5.7, ọgwụ nke 2 mg. Catherine, 51 gbara ya. Anọwo m arịa ọrịa shuga kemgbe afọ 15, n'oge ahụ, agbanwere m ihe karịrị ọgwụ iri na abụọ.

Ugbu a, m na-ewere naanị mbadamba amaryl na Kolya insulin Protafan. A kagbuola Metformin, ha kwuru na ọ baghị uru, site na insulin ngwa ngwa enwere m obi ọjọọ. N'ezie, shuga ezughị okè, mana enwere ntakịrị nsogbu. Alexander, 39 afọ tụlere. A họrọara m ọgwụ ịsalata shuga ogologo oge ma sie ike. Metformin abanyeghị n'ụdị ọ bụla, ọ gaghị ekwe omume iwepụ nsonaazụ ndị ọzọ.

N’ihi ya, anyị biri na Amaril na Glukobay. Ha na-ejide shuga nke ọma, hypoglycemia ga-ekwe omume naanị ma ọ bụrụ na ị rie nri n'oge. Ihe niile dị mma ma buru amụma, enweghị egwu ịghara iteta n'ụtụtụ. N'otu oge, kama Amaril, ha nyere ndị Russia Glimepiride Canon. Ahụghị m ọdịiche ọ bụla, belụsọ na nkwakọ ngwaahịa ahụ amachaghị mma.

Biko rụba ama: You rọrọ iji kpochapụ ọrịa shuga otu oge? Mụọ otu esi emeri ọrịa ahụ, na-eji ọgwụ ọgwụ dị oke ọnụ mgbe niile, na-eji naanị ... >>gụkwuo ebe a

Ọrịa mamịrị, Maninil na ọgwụ ndị yiri shuga - nke ka mma ịrịa ọrịa shuga.

Approzọ ịgwọ ụdị ọrịa shuga mellitus 2 (DM) na-agbanwe kwa afọ. Nke a bụ n'ihi mmepe nke sayensị sayensị, nkọwa nke ihe ndị kacha akpata ya na otu dị iche iche ihe egwu.

Ruo taa, ụlọ ọrụ na-emepụta ọgwụ nwere ike inye klaasị 12 nke ọgwụ dị iche iche, nke dị iche na usoro ịme ihe na ọnụahịa ọnụahịa.

Nnukwu ọgwụ na-ebutekarị ọgba aghara n'etiti ndị ọrịa na ọbụna ndị ọkachamara n'ịgwọ ọrịa. Nke a abụghị ihe ijuanya, maka na onye nrụpụta ọ bụla na-anwa inye ihe na-arụ ọrụ ọrụ aha ọhụrụ.

N'isiokwu a, anyị ga-atụle Diabeton, analogues na ntụnyere ọgwụ ndị ọzọ. Ọgwụ a bụ ihe kachasị ewu ewu n'etiti ndị endocrinologists. Nke a bụ kachasị n'ihi ịdị mma ọnụahịa dị mma.

Diabeton na Diabeton MV: iche

Ọrịa mamịrị - ihe na-arụ ọrụ nke ọgwụ ahụ bụ glycoslazide, nke na-ezo aka na usoro sulfonylurea. Kemgbe ihe karịrị afọ 50 na ahịa, ọgwụ gosipụtara ezigbo profaịlụ nchekwa yana arụmọrụ ọgwụ.

Diabeton na-akpali njikọ nke insulin site na mkpụrụ ndụ beta nke pancreas, na-akwalite ntoputa nke glucose na anụ ahụ, na-ewusi mgbidi vaskụla ike, na-egbochi mmepe nke nephropathy.

Mbadamba ụta Diwara MV 60 mg

O nwetụrụ mmetụta na-emetụta usoro nke coagulation ọbara. Ihe ọghọm dị ukwuu nke ọgwụ ahụ bụ ntọhapụ ya na-ezighi ezi ma si otú a nwee mmetụta dị egwu n'oge ụbọchị. Usoro metabolism yiri nke ahụ na-akpata mgbanwe dị ukwuu na ọkwa nke glycemia.

Ndị ọkà mmụta sayensị achọpụtala ụzọ ha ga-esi gbasaa ọnọdụ a ma kee Diabeton MV (ewepụtara nwayọ nwayọ) Ọgwụ a dị iche na nke onye buuru ya ụzọ na ntọhapụ dị nwayọ na nwayọ nke ihe arụ ọrụ - glyclazide. Ya mere, a na-edobe glucose na ụdị plateau.

Ọgwụ ndị ahụ emepụtaghị iche na usoro ọgwụ.

Enwere m ike iri otu oge?

Ngwakọta nke Maninyl gụnyere glibenclamide - ihe na-arụ ọrụ, nke, dị ka gliclazide, bụ nke usoro sulfanylurea.

Nhọpụta nke ndị nnọchi abụọ nke otu klas ahụ ọgwụ anaghị adị mma.

Nke a bụ n'ihi eziokwu ahụ bụ na ihe ọghọm nke ịmụba nsogbu na-abawanye.

Na Glucophage

Ihe na-arụ ọrụ nke Glucofage bụ metformin, onye nnọchiteanya klas biguanide. Ndabere nke usoro ihe bụ mmụba na nnabata glucose na mbelata ọnụego nnabata nke carbohydrates na eriri afọ.

Mbadamba ọgwụ Glucophage 1000 mg

Dabere na nkwenye nke American Association of Clinical Endocrinology (2013), a na-edenye metformin bụ maka ụdị ọrịa shuga 2. Nke a bụ ihe a na-akpọ monotherapy, na enweghị ike enwere ike ịgụnye ya na ọgwụ ndị ọzọ, gụnyere Diabeton. Yabụ, iji otu ọgwụ a n’otu oge nabatara ma zie ezi.

Ọ dị mkpa icheta na naanị endocrinologist kwesịrị ịhọrọ ma jikọta ọgwụ.

Glyurenorm gụnyere glycidone, onye nnọchi anya klas sulfanylurea.

N'ihe banyere ịdị irè na nchekwa, ọgwụ a ka nke Diabeton oke, ma n'otu oge ahụ ọ dị ọnụ karịa (ihe fọrọ nke nta ka ọ bụrụ ugboro abụọ).

N’etiti uru ọ ga-kwesiri iburu ụzọ dị mma eji arụ ọrụ, obere ihe ọghọm hypoglycemia, ezigbo bioavailability. Enwere ike ịkwado ọgwụ ahụ ka ọ bụrụ akụkụ nke ọgwụgwọ dị mgbagwoju anya nke ọrịa shuga.

Glimepiride (aha ahia Amaryl) bu nkpuru nke ano nke ano nke ihe uku emere nijo ndi ozo.

Na-akpali mmepụta nke insulin na -akpata insulin ogologo oge ogologo oge (ruo 10 - 15 awa).

Ọ na - egbochi nsogbu mamịrị dị ka nkwarụ anya na nephropathy.

Na-emegide nzụlite Amaril, ihe ize ndụ nke ịmalite hypoglycemia bụ 2 - 3%, na iche na ọrịa mamịrị (20 - 30%).Nke a bụ n'ihi eziokwu ahụ bụ na glimeperide anaghị egbochi egbochi glucagon na nzaghachi maka mbelata ọkwa glucose ọbara. Ogwu ahu nwere oke onu ahia, nke metutara ihe diri uwa nile.

Na mmalite ọgwụgwọ maka ọrịa mellitus nke ọrịa ọhụụ chọpụtara, ndị dọkịta na-atụ aro ịgbanwe ụdị ndụ (oke ibu, ịba ụba mmega ahụ). Na enweghi ike, a na-ejikọ ọgwụgwọ ọgwụ na Metformin.

Mbadamba Maninil 3.5 mg

A na-ahọrọ ọgwụ a n'ime otu ọnwa, a na-enyocha glycemia, metabolism lipid, na protein protein renal. Ọ bụrụ na, megide usoro ọgwụgwọ ya na Metformin, ọ gaghị ekwe omume ịchịkwa ọrịa ahụ, mgbe ahụ, a na-enye ọgwụ nke otu ọzọ (nke na-abụkarị usoro sulfanilurea) - usoro ọgwụgwọ abụọ.

N'agbanyeghị eziokwu ahụ bụ na echepụtara Maninil na mmalite 60s, ọ nọgidere na-ewu ewu ma soro Diabeton na-asọmpi. Nke a bụ n'ihi ntakịrị ọnụahịa na nnweta buru ibu.Nhọrọ nke ọgwụ kwesiri ime site na endocrinologist na ndabere nke akụkọ ahụike na ọmụmụ ụlọ ọgwụ na ụlọ nyocha.

Glibomet bụ otu n'ime ọtụtụ ọgwụ ndị jikọtara shuga na-ebelata. Ọ mejupụtara 400 mg nke metformin hydrochloride yana 2.5 mg nke glibenclamide.

Glibomet dị mma karịa Ọrịa mamịrị.

Ya mere, n'ụdị otu mbadamba, onye ọrịa na-ewere ihe abụọ dị ike nke ìgwè dị iche iche n'ịgwọ ọgwụ n'otu oge.

Okwesiri iburu n’uche na ijiko ogwu, onodu ojoo nke nsogbu, tinyere onodu hypoglycemic. Ekwesịrị ịkpachara anya n'okpuru nlekọta nke endocrinologist na ndị na-egosi ụlọ nyocha.

Ihe na-arụ ọrụ nke Glucofage bụ metformin hydrochloride.

Edere ya tumadi maka ọrịa mellitus ọhụrụ chọpụtara na nri nke nri. Ọ nwere ọtụtụ mmetụta ọjọọ dị njọ, dịka ọmụmaatụ, mmepe nke lactic acidosis na hypoglycemia.

N'ihi ya, Diabeton bụ ọgwụ dị mma, n'adịghị ka Glucofage, ọ na - akpali insulin nke insulin ọgwụ endogenous.

Gliclazide MV

Gliclazide jiri nwayọ wepụta ihe na-arụ ọrụ nke ọma na-edozi ọkwa nke glycemia, ebe ị na-a thisụ ọgwụ a, ihe fọrọ nke nta ka ọ bụrụ ọnọdụ hypoglycemic.

N'ihi nsị nke kemịkalụ ahụ, enwere ike iwere ya otu ugboro n'ụbọchị.

Mgbe iji ogologo oge gachara, ahụghị ihe iri mmadụ riri ahụ na mbelata nke ọrụ (anaghị egbochi insulin).

Ngwongwo Antiaggregide nke Gliclazide MV, mmetụta mmetụta nkwụghachi n'ahụ akwara vaskụla. Diabeton kariri arụmọrụ, profaịlụ nchekwa, mana ọnụ ala karịa nke ukwuu.

Site na mmezi ego nke onye ọrịa, enwere ike ịkwado Gliclazide MV dị ka ọgwụ ịhọrọ maka ọrịa shuga.

Glidiab MV

Glidiab MV nwere gliclazide, nke ewepụtara nwayọ. E jiri ya tunyere Diabeton MV, a ga-edenye ọgwụ abụọ ahụ n'otu ọnọdụ ahụike, nwere obere nsonaazụ yana mmeghachi omume na-adịghị mma.

Ihe niile ị chọrọ ịma gbasara Diabeton na vidiyo a:

Ọ dị mkpa icheta na ọrịa shuga bụ ụzọ ndụ. Ọ bụrụ na mmadụ akwụsịghị omume ọjọọ, ọ naghị elekọta ahụ ya, mgbe ahụ, otu ọgwụ agaghị enyere ya aka. Yabụ, ndị sayensị achọpụtala na n’afọ 2050, mmadụ atọ ọ bụla bi n’ụwa ga-arịa ọrịa a.

Nke a bụ n'ihi mbelataala nri nri, nsogbu na - eto oke ibu. N'ozuzu, ọ bụghị ọrịa shuga n'onwe ya bụ ihe jọgburu onwe ya, mana nsogbu ndị ọ na-akpata. Otu n'ime nsogbu ndị a na-ahụkarị bụ mhụhụhụhụhụhụhụhụhụhụhụhụhụro ọzo, akwara kesara, ụkwara ume ọkụ na akụkụ ụbụrụ.

Mbibi nke arịa na akwara nke ala nsọ ahụ na-eduga na nkwarụ oge. Enwere ike igbochi nsogbu ndị a niile dị n'elu ma ọ bụrụ na agbaso ndụmọdụ ndị endocrinologist.

Ngwakọta, usoro onunu ogwu, udiri usoro

Ogwu ahu nwere ihe di iche iche nke glimepiride na metformin. N'ime otu mbadamba nkume, itinye uche ha bụ 1 mg na 250 mg, karị, na nke ọzọ - ọnụọgụ abụọ: 2 na 500 mg.

Ngwakọta nke ihe ndị ọzọ a na-agakọ bụ otu ihe: lactose (n'ụdị nke monohydrate), sodium CMC, povidone-K30, CMC, crospovidone, E572.
Ngwa nke ihe mkpuchi fim ahụ: hypromellose, macrogol-6000, E171, E903.

Illsgwọ nke otu ụdị oval, convex n’akụkụ abụọ ya, nke ejikọtara na fim ọcha. Ha di iche na akara: n'otu uzo nke 1 mg / 250 mg porn, etinyere HD125, na akara Amiil-M (2/500) nwere akara ka ejiri akara HD25.

Typesdị Amaril M na-achịkọta ọgwụ abụọ. Na ngwugwu nke kaadiboodu dị arọ - 3 efere na mbadamba ihe, adịghị adị.

Ngwongwo na-agwọ ọrịa

Ngwakọta ọgwụ eji eme ihe, ihe a na-ekwu maka ya bụ akụrụngwa nke ihe ndị nọ n'ọrụ (glimepiride na metformin).

Ihe mbu bu otu ndi mmadu ndi ozo di iche iche ndi sulfonylurea. O nwere ikike ime ka imepụta na ntọhapụ nke insulin site na sel nke pancreas, na-abawanye ike nke adipose na akwara anụ ahụ na nsonaazụ nke ihe endogenous. A na - enweta hypoglycemic mmetụta dị elu site na nke dị elu, na ọdịiche nke ụmụ nke abụọ nke sulfonamides, ikike nke ihe iji mezie ego insulin na-arụpụta ahụ. Otu ihe ahụ na-ahụ maka na ọgwụ nwere ike belata ihe egwu hypoglycemia.

Dika ihe ndi ozo nke sulfonylurea, ihe ndi ozo nke Amaril M na-ebelata iguzogide insulin, nwere uto antioxidant, na-egbochi egbochi oria, ma belata ọnya CCC. Na-eme njem nke glucose na anụ ahụ yana ojiji ya, na-akpali metabolism.

Mgbe usoro nchịkwa ọnụ nke 4 mg (nha kwa ụbọchị), enwere ikehego ihe kachasị n’otu n’ime ọbara ka awa 2.5 gachara. Na-eri nri ọ nweghị mmetụta ọ bụla na ntinye, na-agbada ngwa ngwa.

O nwere ikike ịbanye n’ime mmiri ara ara ma gafere n’afere. A na-agbanwe ya na imeju, na-akpụpụta ụdị metabolites abụọ, nke a na-ahụ na mmamịrị na feces.

Akụkụ akụkụ dị mkpa nke ihe ahụ mejupụtara ahụ site na akụrụ ya na ụfọdụ gafere ya na eriri afọ.

A na - etinye ihe nwere hypoglycemic mmetụta n’òtù biguanides. Ike ya belata shuga nwere ike gosipụta onwe ya naanị ma ọ bụrụ na emebe insulin na-emebi emebi. Ihe ahụ emetụtaghị β-sel nke pancreas ma n’ụzọ ọ bụla so emepụta insulin. Mgbe etinyere na usoro onunu ogwu echekwara, ọ naghị akpalite mmetụta hypoglycemic.

Ruo ugbu a, ekwenyebeghị usoro nke ihe o mere. Ekwenyere na ọ nwere ike ịkwalite mmetụta nke insulin. A maara na ihe nwere ike ime ka anụ ahụ nwee insulin ike site na ịbawanye ọnụ ọgụgụ ndị na - anabata insulin na mkpụkọ sel. Na mgbakwunye, metformin na-ebelata mmepụta nke glucose na imeju, na-ebelata nguzobe nke FA n'efu, na-egbochi metabolism abụba, na-ebelata ọdịnaya nke ọbara mgbali elu. Ihe ahụ na-ebelata agụụ, si otú a na-enye aka na ichekwa ibu nke ndị ọrịa mamịrị ma ọ bụ belata ibu ya.

Mgbe nchịkwa ọnụ gasịrị, ọ na-etinye obi gị dum na ngọngọ nri. Iri nri nwere ike wedata aka ma gbochie ya. A na-ekesa ya ozugbo site na anụ ahụ, ihe fọrọ nke nta ka ọ ghara ejikọ ya na protein protein. Ọ fọdụ nke anaghị metabolized.

Ctọpụ anụ ahụ na-aputa site na akụrụ. Ọ bụrụ na akụkụ ahụ anaghị arụ ọrụ nke ọma, mgbe ahụ enwere ihe ize ndụ nke nchịkọta nke ihe ahụ.

Ofzọ nke ngwa

A na-agbakọ ọnụ ahịa ọgwụ ahụ n'otu n'otu maka onye ọrịa ọ bụla dabere na ngosipụta nke glycemia. Ọgwụgwọ na Amaril M, dị ka ntuziaka maka iji mee ihe, a na-atụ aro ka ịmalite site na ntakịrị ala ebe enwere ike ịchịkwa hypoglycemic zuru oke. Mgbe nke a gasiri, enwere ike igbanwe uzo ogwu gi dabere na egosiputa glucose di n’ime obara.

Ọ bụrụ na mbadamba ihe ga-efu gị, mgbe ahụ ị gaghị enwe ike ịtụgharị ọgwụ furu efu n'ọnọdụ ọ bụla, ma ọ bụghị ya nwere ike ịkpalite mbelata nke ogo nke glycemia. E kwesịrị ibu ụzọ gwa ndị ọrịa ihe ha ga-eme n’ụdị ndị ahụ.

Site na njikwa glycemic dị mma, mgbe enwere mmụba na nsonaazụ insulin, mkpa ọgwụ nwere ike ibelata n'oge usoro ọgwụgwọ Amaril M. Iji gbochie hypoglycemia, ịkwesịrị ibelata usoro ị ga-eji n'oge ma ọ bụ kwụsịchaa mbadamba.

Ọ bụ dọkịta ga-ekpebi usoro ọgwụgwọ ahụ, mana ndị nrụpụta na-atụ aro ị drinkingụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. Ego nke metformin nke kachasị anabata maka otu ọgwụ bụ 1 g, kwa ụbọchị - 2 g.

Iji gbochie hypoglycemia, na mmalite ọgwụgwọ, ị ofụ ọgwụ nke mbadamba ekwesịghị ịdị elu karịa usoro metformin na glimepiride kwa ụbọchị, nke onye ọrịa ahụ weere ụzọ mbụ. Ọ bụrụ na a na-ebufe ọrịa shuga na Amaryl-M site na ọgwụ ọjọọ ndị ọzọ, mgbe ahụ, a na-agbakọta usoro usoro ahụ dabere na ego ejiri na mbụ. Ọ bụrụ na ọ dị mkpa ịbawanye dose nke ọgwụ, ọ kachasị mma ịbawanye ya site na ọkara mbadamba ọgwụ nke Amaril M 2 mg / 500 mg.

Ọkacha mara ọkachamara na-ekpebi oge ọ ga-eji ihe ọ ga-eji eme ihe, ọ kwadoro ọgwụ a.

N’oge ime ime na inye nwa ara

Ọgwụ ụmụ nwanyị dị ime na ụmụ nwanyị na-akwadebe maka nne. Nwanyị na-atụ anya kwesịrị ịgwa dọkịta ya ozugbo banyere ebumnuche ya ma ọ bụ ihe omume ịtụrụ ime n’oge ọgwụgwọ hypoglycemic, ka o wee wepụta ọgwụ shuga ọzọ ma ọ bụ bufee ya na ọgwụ insulin.

Nnyocha e mere na anụmanụ anụmanụ gosipụtara na metformin dị na ọgwụ nwere ike ibute mmepe ahụ ẹmbrayo / nwa ebu n’afọ ma na-emetụta nwatakịrị n’oge a na-amụ nwa.

A maara na metformin nwere ike ịbanye mfe mmiri ara. Yabụ, iji gbochie mmetụta ọjọọ nke ihe ahụ n'ahụ ahụ nwatakịrị ahụ, a na-atụ aro ka nwanyị ahụ jụọ nwa ara ma ọ bụ tụgharịa na ọgwụ ndị ọzọ nwere mmetụta hypoglycemic nke kwere ka ndị nọọsụ.

Ntuziaka na mgbochi

Ọnụ ego: (1 mg / 250 mg) - 735 rubles., (2 mg / 500 mg) - 736 rubles.

E kwesịghị iwere mbadamba Amaryl M ọ bụrụ:

Ọrịa shuga Idị
Ihe ojoo nke oria shuga: ketoacidosis (tinyere akuko nke), ndi nna nna na coma
Metaboldị metabolic acidosis ọ bụla (nnukwu ma ọ bụ nke na-adịghị ala ala)
Ọrịa ọrịa imeju siri ike (n'ihi enweghị ahụmịhe zuru oke)
Ahụ ike
Ọdịda akwara na ọrịa a na-egbu egbu (ike nke lactic acidosis)
Ọnọdụ ọ bụla siri ike nke nwere ike imetụta ọrụ akụrụ (akpịrị ịkpọ nkụ, ọrịa dị mgbagwoju anya, iji ọgwụ ayodiin).
Ọrịa na-emetụta oke ikuku oxygen n'ime anụ ahụ (nkụda obi, infarction myocardial, ujo)
Ahụ ahụ ga - eme ka aru lactic acidosis (Akụkọ gbasara lactacidemia)
Ọnọdụ nrụgide (mmerụ ahụ dị mgbagwoju anya, ihe ọkụ ma ọ bụ kemịkal, ihe ndị metụtara ịwa ahụ, ọnya na-efe efe, ọnya ọbara)
Nri a na-edozighi emebi n'ihi agu, nri ndi nwere obere carb, na nsogbu adighi
Ọ bụrụ na mmadụ na-anara onwe ya na ngarị (paresis na bowel mgbochi)
Alcoholenceụbiga mmanya na-egbu egbu oge, ị overụbiga mmanya ókè
Erimeri n'ahụ nke lactase, ọgụ galactose, ọrịa GH malabsorption syndrome
Pkwadebe maka ịtụrụ ime, ịtụrụ ime, na nwa
N’agbata afọ 18 (n’ihi enweghị nchekwa ihe nchebe maka ahụ anụ ahụ)
Ọkwa dị elu nke uche mmadụ ma ọ bụ ịnagide ihe niile dị na nkwadebe ahụ, yana ọgwụ ọ bụla nwere njeri sulfanilurea, biguanides.

Ihe ichoro ima banyere mgbe ị na-edeputa Amaril M

Na mmalite ọgwụgwọ, enwere ike ịba ụba hypoglycemia ga-ekwe omume, yabụ, ruo ọtụtụ izu, ịkwesịrị nyochaa nke ọma ma, ọ bụrụ na ọ dị mkpa, glycemia ziri ezi. Ihe ndị dị ize ndụ bụ:

Enweghị ike nke onye ọrịa ma ọ bụ enweghị njikere ime ihe ndị dọkịta kwuru
Oriri na-adịghị mma (nri na-adịghị mma, nri oge na-adịghị mma, ike na-enweghị ike ịmegharị mmebi)
Alcoholụ mmanya na-egbu egbu
Ọrịa metabolism n'ihi ọrịa endocrine (ọrịa thyroid, arụ ọrụ nke akụkụ nke GM na-ahụ maka usoro metabolic)
Isonye Ọrịa
Drugsnweta ọgwụ ndị ọzọ n'echebaraghị ngakọrịta ha na Amaril M
N'ime ndị agadi: akụrụngwa akwara na-egbu oge, enweghị mgbaàmà ọ bụla
Medicationsnweta ọgwụ na-emetụta ọnọdụ nke akụrụ (na-a diụ ihe ọ thatụ thatụ na-ebelata ọbara mgbali elu, NSAIDs, wdg)
Mbelata ma ọ bụ gbagọrọ agbagọ nke ihe na - ebido hypoglycemia.

Mkparịta ụka ọgwụ ọjọọ

N'oge usoro ọgwụgwọ na Amaril M, ekwesịrị iburu n'uche na ihe abụọ ahụ dị arụ ọrụ dị n'ime ya nwere ike ịbanye n'otu n'otu ma ọ bụ jikọọ mmeghachi omume na-adịghị mma nke mmiri ọgwụ ndị ọzọ. N'ihi nke a, nke a nwere ike imetụta oke ọgwụgwọ ma ọ bụ njikwa glycemic ma duga na ndapụta na-enweghị atụ.

Mgbanwe Metabolic pụtara na ntinye aka kpọmkwem nke CYP2C9 isoenzyme. Ya mere, akụrụngwa ya gbanwere ma ejiri ya na ihe inhibido ihe ma ọ bụ ihe ndị ọzọ. Ọ bụrụ na ngwakọta ndị dị otú ahụ dị mkpa, ọ dị mkpa iji nyochaa usoro onyonye ziri ezi yana, ọ bụrụ na ọ dị mkpa, mezie ya:

A na - eme ka mmụba shuga nke glimepiride dị n'okpuru ikike nke ACE inhibitors, anabolics, homonụ nwoke, ọgwụ na coumarin, MAO, cyclophosphamide, phenfluramine, pheniramidol, fibrate, fluconazole, salicylates, sulfanilamides, ọgwụ nje tetracycline na tetracyclines.
A na-ebelata hypoglycemic mmetụta mgbe ejiri Amaril M na Acetazolamide, barbiturates, diuretics, sympathomimetics, GCS, nnukwu nicotinic acid, glucagon, homonụ (thyroid, estrogens, progestogens), Phenothiazine, Rifampicin, iji ọgwụ na-egbu ogologo oge.

Mmeghachi omume ndị ọzọ enwere ike:

N’ime njikọta ya na ndị na - emegide ọgwụ nke ndị na-anabata H2-histamine, BAB, Clonidine, Reserpine, mmetụta nke Amaril M nwere ike ịgbanwu, na-abawanye ma ọ bụ belata. Iji gbochie ọnọdụ ndị na-adịghị mma, ọ dị mkpa iji nlezianya nyochaa glycemia ma, dabere na ndị na-egosi ya, gbanwee ọnụego ọgwụ kwa ụbọchị. Na mgbakwunye, ọgwụ nwere oke mmetụta na ndị nabatara NS, n'ihi nke a na-akpaghasị azịza ọgwụgwọ. N'aka nke ya, nke a nwere ike ibute mbelata ịdị njọ nke ihe mgbaàmà hypoglycemia, nke ga-eme ka egwu dịkwuo ike.
Site na ngwakọta nke glimepiride na ethanol megide oke oriri riri oke ma ọ bụ ụdị ịhoụbiga mmanya ókè, mmetụta hypoglycemic ya nwere ike ịbawanye ma ọ bụ ibelata.
Mgbe ejikọtara ya na usoro coumarin, anticoagulants na-apụtakarị, mmetụta ha na-agbanwe n'otu uzo ma ọ bụ ọzọ.
Mwepu nke glimepiride site na eriri afọ na-agbadata n'okpuru nduzi nke Kolesevelam, ọ bụrụ na e buru ya n'ihu Amaril M. Ma ọ bụrụ na ị drinkụọ ọgwụ ahụ na ntụgharị site na obere oge ọ dịkarịa ala 4 awa, mgbe ahụ ọ nweghị nsonaazụ na-adịghị mma ga-apụta.

Njirimara mmeghachi omume nke metformin yana ọgwụ ndị ọzọ

Njikọ ndị a na-achọghị

Njikọ ya na ethanol. Na ị alcoholụ mmanya na-egbu egbu, ihe ize ndụ nke lactic acidosis na-abawanye, ọkachasị megide njupụta nri ma ọ bụ iri nri oriri, ọnụnọ nke ịrụ ọrụ umeji ezughi oke. N'oge usoro ọgwụgwọ Amaril M, mmadụ kwesịrị izere ị drinksụ mmanya na ọgwụ ọjọọ nwere.
Na ayodiin nwere ihe ndi ozo di iche. Mgbe ị na-ejikọ usoro ọgwụgwọ Amaril M na usoro metụtara nchịkwa intravascular nke ndị na-ahụkarị, ihe ize ndụ nke mmebi akụrụ na-abawanye. N'ihi ezughị ezu nke akụkụ ahụ, metformin na-agbakọta na mmepe na-esote lactic acidosis. Iji gbochie ọnọdụ dị njọ, Amaril M kwesịrị ịkwụsị ị Amarụ mmanya ụbọchị 2 tupu usoro ndị nwere ayodiin nwere, ma ghara iwepụta otu oge mgbe nyochachara ọgwụ. A na-ahapụ ya ịmaliteghachi usoro ahụ naanị mgbe ị nwetasịrị data na enweghị ọghọm n'ọnọdụ ọnọdụ akụrụ.
Njikọ ya na ọgwụ nje na-emetụta akụrụ ya na-eduga na ịmalite nke lactic acidosis.

Nchikota enwere ike ya na metformin, nke eji gha akpachara anya.

Mgbe ejikọtara ya na corticosteroids mpaghara ma ọ bụ systemic, diuretics na 2-adrenostimulants, a ga-enyocha glycemia ụtụtụ karịa ka ọ na-adị (karịchaa na mmalite nke usoro mgbagwoju anya) ka o wee kwe omume iwezigharị usoro oge ọgwụgwọ ma ọ bụ mgbe ọpụpụ ụfọdụ ọgwụ.
Mgbe ejikọtara ya na ACE inhibitor na metformin, ọgwụ mbụ nwere ike belata glycemia, yabụ, a ga-achọ mgbanwe onunu ogwu n'oge ọgwụgwọ ma ọ bụ mgbe ọpụpụ nke onye na - egbochi ACE.
Mgbe ejikọtara ya na ọgwụ ọgwụ nwere ike ịkwalite nsonaazụ nke metformin (insulin, anabolics, sulfonylurea na ọgwụ, aspirin na salicylates), ịhazi usoro nke glucose dị mkpa iji gbanwee ma mezie usoro nke metformin mgbe ịkagbu ọgwụ ndị a megidere usoro ọgwụgwọ na-aga n'ihu na Amaril M.
N'otu aka ahụ, njikwa glycemic dị mkpa mgbe ejikọtara Amaril M na ọgwụ na-ebelata ike ya (GCS, homonụ thyroid, ọgwụ thiazide, ọgwụ mgbochi, ọmịiko, ndị na-emegide calcium, wdg) iji dozie usoro ma ọ bụrụ na ọ dị mkpa.

Nsonaazụ

Mmetụta ọjọọ nke iwere Amaril M bụ n'ihi njirimara nke metformin na glimepiride, yana mmetụta ha jikọtara na usoro ahụ.

Enwere ike ị nweta nsonaazụ ndị edepụtara dị n'okpuru ebe a bụ ahụmịhe ahụike na glimepiride na usoro ndị ọzọ sulfanylurea. Hypoglycemia nwere ike ịgbatị oge. Ọ na-egosi n'ụdị:

Isi ọwụwa
Agụụ mgbe niile
Nausea, mkpọtụ nke ọgbụgbọ
Isi ike
Nsogbu ihi ụra (ehighị ụra nke ọma ma ọ bụ ụra efu)
Nessba ụjọ, ụjọ
Iwe iwe n'echeghị echiche
Enweghi ike itinye uche, wedata uche
Ihe mgbochi nke mmeghachi omume psychomotor
Mgbagha
Ọnọdụ dara mbà n'obi
Ọrịa uche na mpaghara ahọpụtara
Ọhụhụ ụzọ
Nkwarụ okwu
Seizures
Ainchọta
Ntinye ume dị mkpụmkpụ, bradycardia
Oyi, nke nnyapade
Tachycardia
Ọbara mgbali elu
Obi palpitations
Arrhythmias.

N'ọnọdụ ụfọdụ, mgbe hypoglycemia dị oke njọ, enwere ike ịgbagha ya na nsogbu mgbasa ọbara na GM. Ọnọdụ ahụ na-adị mma mgbe ekpochapụ hypoglycemia.

Nsonaazụ ndị ọzọ

Mmetụta anya: mbelata nke oge dị njọ (ọkachasị na-eme na mbido ọgwụgwọ). Ọ na-eme site na mgbanwe na glycemia, nke na-akpata ọzịza nke akwara optic, nke gosipụtara na mpaghara ntụgharị.
Ahụ gastrointestinal: ọgbụgbọ, mkpọtụ nke ọgbụgbọ, ihe mgbu, afọ ọsịsa, ịmịcha, mmetụta nke juju.
Imeju: ịba ọcha n'anya, ịgbalite enzymes akụkụ, jaundice, cholestasis. Site na mgbanwe nke ọrịa, mmepe nke ọnọdụ ndị na-eyi ndụ onye ọrịa egwu. Ọnọdụ ahụ nwere ike ịka mma mgbe ndọrọ ọgwụ gachara.
Akụkụ Hematopoietic: thrombocytopenia, mgbe ụfọdụ leukopenia na ọnọdụ ndị ọzọ n'ihi mgbanwe nke ihe mejupụtara ọbara.
Ihe mgbochi: ihe nfụkasị ahụ na ihe mgbaàmà nfụkasị ụgha (ọnya, itching, urticaria). A na-egosipụtakarị na obere oge, mana mgbe ụfọdụ ha nwere ike inwe ọganihu, nke dyspnea gosipụtara, mbelata ọbara mgbali, ujo anafilactic. Enwere ike ịbụ ihe mmerụ ahụ na-ekpugide mkpokọ mmiri ma ọ bụ ihe ndị yiri ya. Ọ dị mkpa ịkpọtụrụ ọkachamara.
Mmeghachi omume ndị ọzọ: ịba ụba nke dermis ka ìhè anyanwụ na radieshon UV.

Mmetụta kachasị emetụta mgbe ejiri ọgwụ metformin na-eji ọgwụ ọjọọ eme ihe bụ lactic acidosis. Na mgbakwunye, ihe ahụ nwere ike ibute ọgbaghara na arụ ọrụ nke sistem na akụkụ ahụ.

Akụ na-emetụta nri: ọtụtụ oge - ọgbụgbọ, mkpọtụ nke ọgbụgbọ, mgbu, flatulence, ịba ụba gas, agụụ. Mgbaàmà na-adịkarị, oge a na-ahụ maka mmalite ọgwụgwọ.Ka ị na-aga n’ihu ịnwere Amaril M pụọ n’anya nke ha. Iji belata ọnọdụ ahụ mgbe ọgwụ ọgwụ ahụ kwụsịrị ma gbochie ya, a na-atụ aro ka iwelie usoro ahụ nke nta nke nta, ma jikọta ọgwụ ahụ na nri. Ọ bụrụ na nnukwu afọ ọsịsa na / ma ọ bụ ọgbụgbọ malitere, ihe ga-esi na ya pụta nwere ike ịbụ akpọnwụ akpịrịkpa na azotemia prerenal. N'okwu a, a ga-akwụsị ịgwọ ọrịa Amaril M ruo mgbe ọnọdụ ahụike kwụsiri ike.
Akụkụ Sense: afụfaste “ọla” na-adịghị mma
Imeju: arụ ọrụ nke ahụ nke ọma, ịba ọcha n'anya (enwere ike ịlaghachi azụ ma ọ kwụsịchaa ọgwụ). N'ọnọdụ nsogbu imeju, onye ọrịa ahụ kwesịrị ịkpọtụrụ onye na-ahụ maka ọgwụgwọ ngwa ngwa o kwere omume.
Akpukpo ahu: itching, ihe ngbu, erythema.
Akụkụ Hematopoietic: anaemia, leukemia na thrombocytopenia. N'ihe di ogologo, enwere obere odidi nke vit. B12 na ọbara, ihe mere megaloblastic anaemia.

Mpempe mwepụta

Amaryl na-ere ya n'ụdị mbadamba. Agba na-adabere na usoro onodu ogwu ji arụ ọrụ:

1 mg glimepiride - pink,
2 - akwụkwọ ndụ akwụkwọ ndụ
3 - odo edo edo
4– acha anụnụ anụnụ.

Ha dị iche na akara ndị etinyere na mbadamba.

Mmekorita

Tupu ịkọwa Amaryl, dọkịta kwesịrị ịchọpụta ọgwụ ọgwụ onye ọrịa ahụ na-a .ụ. Medicationsfọdụ ọgwụ na-akwalite, ndị ọzọ belata mmetụta hypoglycemic nke glimepiride.

Mgbe ị na-eduzi ọmụmụ, achọpụtara na ọnụego shuga dị n'ọbara na - achọpụta mgbe a na - eri ya:

ndị na-ahụ maka ọgwụ antidiedi
Phenylbutazone
Oxyphenbutazone,
Azapropasone
Sulfinpyrazone,
Metformin
Tetracycline
Miconazole
salicylates,
MA inhibitors
nwoke nwoke homonụ nwoke
anabolic steroid
ọgwụ nje quinol,
Clarithromycin
Fluconazole
ndị na-eme ebere,
fibrates.

Ya mere, a naghị atụ aro ịmalite ị startụ Amaryl n'onwe gị na-enweghị ị nweta ọgwụ kwesịrị ekwesị n'aka dọkịta.

Ihe ndị a na-esote anaghị emebi ịdị irè nke glimepiride:

progestogens
estrogens
thiazide diuretics,
saluretics
glucocorticoids,
nicotinic acid (mgbe eji oke ogwu),
laxatives (enyere ogologo oge),
mgbochi ego
Rifampicin,
Glucagon.

Ekwesiri iburu ụdị mmetụta a na ịhọrọ usoro onunu ogwu.

Sympatholytics (beta-igbochi, reserpine, clonidine, guanethidine) nwere mmetụta a na-enweghị ike ịkọpụta na hypoglycemic mmetụta nke Amaril.

Mgbe ị na-eji usoro coumarin, rịba ama: glimepiride na-akwalite ma ọ bụ na-emebi mmetụta nke ọgwụ ndị a na ahụ.

Dọkịta ahụ na-ahọrọ ọgwụ maka ọbara mgbali elu, ọgwụ mgbochi mkpali, na ọgwụ ndị ọzọ ama ama.

A na-ejikọ Amaryl na insulin, metformin. A choro ngwakọta a mgbe ị na-ewere glimepiride, ọ gaghị ekwe omume ịnweta njikwa metabolic chọrọ. Ọ bụ dọkịta ka edoziri usoro ị drugụ ọgwụ ọ bụla.

Nchịkọta akọwapụtara nke ihe ndị na - arụ ọrụ nwere ike ịkwalite ịdị irè nke ọgwụgwọ, na - enyere aka ịchịkwa ọnọdụ ndị ọrịa mamịrị n'ụzọ ka mma.

Exbọchị mmebi

Jiri ọgwụ a maka ọnwa 36 ka ahapụpụtara.

Onye endocrinologist kwesịrị ekwesị ga-ahọrọ dochie anya Amaryl kwesịrị ekwesị. Ọ nwere ike ịkọwapụta analog mere na ndabere nke otu ihe eji eme ihe, ma ọ bụ họrọ ọgwụ emere site na ihe ndị ọzọ.

Enwere ike inye ndị ọrịa ọgwụ dochie Russia, Diamerid, nke dị ọnụ ala. Maka mbadamba 30 nke ọgwụ mere na ndabere nke glimepiride, yana ịsụ ọgwụ 1 mg na ụlọ ahịa ọgwụ, ndị ọrịa ga-akwụ 179 p. Site na ntinye nke itinye uche nke ihe na-arụ ọrụ, ọnụ ahịa na-abawanye. Maka diamond na usoro onunu ogwu nke 4 mg, 383 p.

Ọ bụrụ na ọ dị mkpa, jiri ọgwụ Glimepiride mee ọgwụ dochie Amaryl, nke ụlọ ọrụ Russia Vertex rụpụtara. Ọgwụ ndị a adịghị ọnụ. Maka ngwugwu 30 pcs.2 mg ga-akwụ 191 p.

Costgwọ nke Glimepiride Canon, nke Canonfarm mepụtara, dị obere. A na-ewere ọnụahịa nke ngwugwu nke mbadamba 30 nke 2 mg 2 dị ọnụ ala, ọ bụ 154 p.

Ọ bụrụ na glimepiride anabataghị ihe, a na-enye ndị ọrịa ọgwụ analogues ndị ọzọ mere na ndabere nke metformin (Avandamet, Glimecomb, Metglib) ma ọ bụ vildagliptin (Galvus). A na-ahọpụta ha na-eburu n'uche njirimara nke ahụ onye ọrịa.

Ime ime, lactation

N'ime oge mmegharị ahụ nke nwa ahụ n'ime nwa, a na-enye nwa ọhụrụ nwa, a gaghị enwe ike iji ihe ndị a na-enweta na sulfonylurea. N'ime ọbara nwanyị dị ime, itinye uche glucose kwesịrị ịdị n'okpuru oke. E kwuwerị, hyperglycemia na-eduga n'ihe ize ndụ ka ukwuu nke mmerụ ịmụ nwa, na-eme ka ọnụ ọgụgụ ụmụaka na-anwụ.

Aremụ nwanyị dị ime na-agafere insulin. Enwere ike iwepu ihe puru iche na ogwu ojoo uto na umuaka na utero ma oburu na i hapuru sulfonylurea na ngbanye izu ime.

N'oge a na-enye nwa ara, amachibidoro ọgwụgwọ Amaril. Ihe dị n’ime ahụ na-abanye n’ime mmiri ara, anụ ahụ nwa amụrụ ọhụrụ. Mgbe ị na-enye nwa ara, ọ dị mkpa na nwanyị ahụ ga-agbanwerịrị ọgwụ insulin kpamkpam.

Ọrịa shuga na-arịa insulin na-abụghị insulin

Nkọwa nke ụdị usoro onunu ogwu

Amaryl 1 mg: mbadamba pink, oblong, larịị nke nwere ahịrị na abụọ. Kanyere “NMK” ma meekwa “h” n’akụkụ abụọ.

Amaryl 2 mg: mbadamba nkume akwụkwọ ndụ akwụkwọ ndụ, okpukpu kwee, larịị nke nwere ahịrị na akụkụ abụọ. Kanyere “NMM” ma meekwa “h” n’akụkụ abụọ.

3 Amaryl 3 mg: mbadamba nkume na-acha edo edo na-acha odo odo, na-acha uhie uhie, dị larịị nke nwere ahịrị na akụkụ abụọ. Kanyere “NMN” ma meekwa “h” n’akụkụ abụọ.

Amaryl 4 mg: mbadamba nkume na-acha anụnụ anụnụ, oblong, ewepụghị na akara nkewa na akụkụ abụọ. Kanyere “NMO” ma meekwa “h” n’akụkụ abụọ.

Mlọ ọgwụ

Na otutu onunu ogwu glimepiride n’ime ubochi obula nke 4 mg C max n’ime obara n’agha na-enweta ihe dika elekere 2.5 ma obu 309 ng / ml. Enwere mmekọrịta kwụ ọtọ n’etiti dose na C max nke glimepiride na plasma, yana n’etiti dose na AUC. Mgbe inwetara glimepiride ya bioavailability zuru oke. Iri nri anaghị enwe mmetụta dị ukwuu n’ime mmiri, ewezuga ntakịrị nwayọ na ọsọ ya. Ejiri Glimepiride mara oke nkesa nke dị obere (ihe dị ka 8.8 L), ihe ruru nha olu nke nkesa albumin, ogo dị elu nke na-egbochi protein plasma (karịa 99%) na mkpochapu dị ala (ihe dịka 48 ml / min). Nkezi T 1/2, kpebiri site n'ọtụtụ ọbara n'ime ọnọdụ nke nchịkwa ọgwụ ugboro ugboro, ihe dịka awa 5-8. Mgbe ịsesụsịrị nnukwu ọgwụ, enwere ntakịrị mmụba na T 1/2.

Mgbe otu glimepiride, otu ụzọ n'ime 58% nke ọgwụ ahụ bụ akụrụ na 35% nke dose site na eriri afọ. Achọpụtaghị glimepiride na mmamịrị ahụ.

Na mmamịrị na feces, ahụrụ metabolites abụọ na-esite na metabolism na imeju (ọkachasị na-eji CYP2C9), otu n'ime ha bụ ihe malitere hydroxy, nke ọzọ abụrụ na ihe na-ebute mbufụt. Mgbe abatasịrị nke glimepiride, ọnụ T 1/2 nke metabolites ndị a bụ awa 3-5 na awa 5-6, n'otu n'otu.

Glimepiride na-apụ apụ na mmiri ara ara ma na-agafe ihe mgbochi placental.

Tụnyere nke otu na ọtụtụ (otu ugboro kwa ụbọchị) nchịkwa glimepiride ekpugheghị ọdịiche pụtara ìhè na ọgwụ ọgwụ, a na-ahụta ọdịiche ha dị ala n'etiti ndị ọrịa dị iche iche. Onweghi oke nchịkọta ọgwụ.

Pharmacokinetic parampam yiri na ndị ọrịa nke nwoke na nwanyị na ụmụ afọ dị iche iche. N’ime ndị ọrịa nwere nsogbu gbasara akụrụngwa (ya na iwepu ihe dị obere), enwere mmụba nke glimepiride na mbelata ogo mgbanye ya n’ọrụ ọbara, nke, n’ụzọ niile, ga - adị n’ịgwụ ọgwụ ngwa ngwa n’ihi ntakịrị ike ya na protein. N'ihi ya, na ụdị ndị ọrịa a, ọ nweghị ihe ize ndụ ọzọ nke nchịkọta nke ọgwụ.

Mlọ ọgwụ

Glimepiride na-ebelata mkpụkọ glucose n'ime ọbara, tumadi n'ihi mkpali nke ntọhapụ nke insulin na sel beta nke pancreas. Nsonaazụ ya jikọtara ya na nkwalite ike nke mkpụrụ ndụ beta nke na - emeghachi omume na - eme ka mmeghachi omume physiological nwere glucose. Tụnyere glibenclamide, ị doụ glimepiride dị ala na-akpata mwepụta nke insulin obere obere ebe ị na-enweta ihe dị ka otu mbelata n'ọbara glucose ọbara. Eziokwu a na-agba akaebe na ọnụnọ nke extrapancreatic hypoglycemic mmetụta na glimepiride (mmụba anụ ahụ na insulin na mmetụta insulinomimetic).

Ihe nzuzo insulin. Dị ka ihe ndị ọzọ na-emepụta sulfonylurea, glimepiride na-achịkwa izochi insulin site na imekọrịta ihe na potassium protein ATP na membranes beta-cell. N'adịghị ka ihe ndị ọzọ na-eme ka sulfonylurea, glimepiride ahọrọ nke nwere protein dị n'ime kilogram 65 (kDa) nke dị na mkpụrụ ndụ beta pancreatic. Mmekọrịta a nke glimepiride yana protein nwere ya, na-achịkwa mmeghe ma ọ bụ mmechi nke oghere potassium na-emetụta ụbụrụ nke ATP.

Glimepiride na-emechi ụzọ ndị na-eme ka mmadụ sie ike. Nke a na - akpata depolarization nke mkpụrụ ndụ beta ma na - eduga na mmeghe nke ụzọ kalịnda na - eme ka mmadụ nwee mmetụta na - abanye na sel nke sọlfọm n’ime sel N'ihi nke a, mmụba nke itinye uche nke calcium intracellular na-eme ka njigide insulin site na exocytosis.

Glimepiride dị ngwa ngwa ma yikarị ka ọ ga-abata kọntaktị ma wepụta ya na protein na-ejikọ ya karịa glibenclamide. A na-eche na akụ nke oke mgbanwe nke glimepiride nwere protein na-ejikọ ya na-ekpebi utịp uta mmetụta nke mkpụrụ ndụ beta na -emeju glucose na nchedo ha pụọ na nkụda mmụọ na mbelata oge.

Nsonaazụ nke ịba ụba nke anụ ahụ na insulin. Glimepiride na - akwalite nsonaazụ insulin na nnweta nke glucose site na uru anụ ahụ dị n'akụkụ.

Mmetụta insulinomimetic. Glimepiride nwere mmetụta yiri nke insulin na nnweta nke glucose site na akwara akụkụ yana ịhapụ glucose site na imeju.

A na - enweta uru glucose site na uru anụ ahụ site na ibugharị ya n'ime sel na adipocytes. Glimepiride na-abawanye ọnụ ọgụgụ nke ụmụ irighiri ihe na-ebuga glucose na mkpụkọ plasma nke akwara mkpụrụ ndụ na adipocytes. Mmụba na oriri nke mkpụrụ ndụ glucose na-eduga na arụ ọrụ nke glycosylphosphatidylinositol-phospholipase kpọmkwem - C. N'ihi nke a, mkpụkọ akwara intracellular na-ebelata, na-eme ka mbelata ọrụ nke protein kinase A, nke n'aka nke na-eduga na mkpali nke glucose metabolism.

Glimepiride na-egbochi mwepu nke glucose site na imeju site na ịbawanye ụba nke fructose-2,6-bisphosphate, nke na-egbochi gluconeogenesis.

Mmetụta na nchịkọta platelet na nguzobe nke plahe atherosclerotic. Glimepiride na-ebelata nchịkọta platelet na vitro na vivo. O doro anya na mmetụta a jikọtara ya na mgbochi nke COX, nke bụ maka nrụpụta thromboxane A, ihe dị mkpa na nchịkọta platelet endogenous.

Mmetụta ọgwụ antiatherogenic. Glimepiride na - enye aka na nhazi nke ihe ndị dị na lipid, belata ọkwa nke malonic aldehyde n'ime ọbara, nke na - eduga n'ịbelata oke nke peroxidation lipid.

Mbelata ịdị njọ nke nrụgide oxidative, nke a na-adị mgbe niile na ndị ọrịa nwere ọrịa mellitus nke ụdị 2. Glimepiride na-abawanye ọkwa nke α-tocopherol, ọrụ nke catalase, glutathione peroxidase na superoxide dismutase.

Ọkpụkpụ akụrụngwa. Site na channelụ potassium na-emetụta ụbụrụ ATP (lee anya), sulfonylureas nwekwara mmetụta na sistem.N'iji ya na usoro ọdịnala sulfonylurea, glimepiride nwere mmetụta dị ala na sistem ụbụrụ. Ọ na - ebelata platelet na - eduga na mbelata dị egwu na njeri nke atherosclerotic plaques.

N'ime ndị ọrụ afọ ofufo nwere ahụike, ntakịrị opekempe nke glimepiride bụ 0.6 mg. Nsonaazụ nke glimepiride bụ dose dabere na ịmụgharị. A na-emezi mmeghachi omume anụ ahụ maka ọrụ anụ ahụ (belata insulin insulin) na glimepiride.

Enweghị ọdịiche dị mkpa na nsonaazụ ahụ, dabere ma ewerere ọgwụ ahụ nkeji iri atọ tupu nri ma ọ bụ ozugbo nri. N'ime ndị ọrịa nwere ọrịa shuga, enwere ike ịchịkwa nchịkwa metabolic n'ime awa 24 na-eji otu ọgwụ. Ọzọkwa, n'ọmụmụ ihe banyere ụlọ ọgwụ, mmadụ iri na abụọ n'ime mmadụ iri na isii nwere ọrịa akwara (Cl creatinine 4-79 ml / min) nwetakwara akara metabolic zuru oke.

Ngwakọta ọgwụ na metformin. Maka ndị ọrịa na-emepụtaghị njikwa metabolic zuru oke mgbe ị na-eji ọgwụ glimepiride kachasị, ọgwụgwọ ọgwụ na glimepiride na metformin nwere ike ịmalite. N'ime ihe ọmụmụ abụọ, mgbe ị na-eme ọgwụgwọ njikọta, egosipụtara na njikwa metabolic dị mma karịa nke ahụ na usoro ọgwụgwọ ọgwụ ọ bụla iche.

Ngwakọta ọgwụ na insulin. Maka ndị ọrịa na-emepụtaghị ọgwụ metabolic zuru oke mgbe ị na-eji ọgwụ glimepiride kachasị, enwere ike ịmalite ọgwụgwọ insulin n'otu oge. Dabere na nsonaazụ nke ọmụmụ abụọ, iji ojiji a jikọtara ọnụ, a na-enweta nkwalite njikwa metabolic ahụ dịka iji naanị otu insulin, agbanyeghị, na njikọta ọgwụ insulin chọrọ obere ọgwụ insulin.

Jiri na umuaka. Enweghị data banyere ịdịte aka na nchekwa ogologo oge mgbe ị na-eji ọgwụ ahụ na ụmụaka.

Elldị shuga abụọ nke ọrịa shuga (na monotherapy ma ọ bụ dịka akụkụ nke ọgwụgwọ njikọta na metformin ma ọ bụ insulin).

Ime na lactation

A na-enyefe ihe dị n’ime ụmụ nwanyị dị ime. N'ihe dị ime tụwara ime ma ọ bụ mmalite nke afọ ime, a ga-agafara nwanyị na insulin ọgwụ.

Glimepiride na-abanye n’ime mmiri ara, ya mere, enweghị ike ị takenụ ya n’oge a na-enye ya ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Ntụziaka pụrụ iche

Na ọnọdụ nrụgide pụrụ iche nke ụlọ ọgwụ, dị ka trauma, ihe ịwa ahụ, ọrịa nwere ọrịa febrile, enwere ike ịnwe mmebi nke metabolic na ndị ọrịa nwere ọrịa mellitus, ọ nwere ike ịdị mkpa ka ịgbanwere ha ruo oge ụfọdụ iji gwọọ insulin iji nọgide na-enwe usoro metabolic zuru oke.

N’ime izu izizi nke ọgwụgwọ, nsogbu nke ịba ụba hypoglycemia nwere ike ịbawanye, yabụ, achọrọ nlezianya ịbanye n’ọbara glucose na ọbara n’oge a.

Ihe ndi n’enye aka ibute oria obi shuga gụnyere:

Ọrịa ma ọ bụ enweghị ike nke onye ọrịa ahụ (nke a na-ahụkarị na ndị ọrịa agadi) ime ka dọkịta na-arụkọ ọrụ,

Erighị ihe na-edozi ahụ, iri nri na-adịghị agbanwe agbanwe ma ọ bụ na-ahapụ iri nri,

Enweghi ike n’etiti mmega ahu na oriri ndi ahu,

Alcoholụ mmanya na-egbu egbu, karịsịa na nri ndị ịpụsịrị ọnụ,

Nsogbu akwara na-enweghị nsogbu,

Ọrịa hepatic siri ike (na ndị ọrịa nwere nnukwu nsogbu ịba ọcha n'anya, a na-egosipụta nnyefe na ọgwụgwọ insulin, opekata mpe ruo mgbe a ga-enweta njikwa metabolic),

Disordersfọdụ nsogbu ọgbụgba endocrine nke na-agbagha metabolism ma ọ bụ adrenergic counterregulation na nzaghachi hypoglycemia (dịka ọmụmaatụ, ụfọdụ ọrịa thyroid na nkụda mmụọ, enweghi nsogbu adrenal),

N'otu oge eji ụfọdụ ọgwụ (lee mpaghara “Mmekọrịta”),

Nnabata nke glimepiride na enweghị ihe ngosi maka nnabata ya.

Ọgwụgwọ na usoro sulfonylurea, nke gụnyere glimepiride, nwere ike ibute mmepe nke anaemia hemolytic, yabụ, ndị ọrịa nwere ụkọ glucose-6-phosphate dehydrogenase kwesịrị ịkpachapụ anya mgbe edere glimepiride na ọ ka mma iji hypoglycemic waksị na-abụghị ihe mgbawa sulfonylurea.

Na ọnụnọ nke ihe ndị dị n'elu dị ize ndụ, mmepe nke hypoglycemia nwere ike ịchọ nhazi nke glimepiride ma ọ bụ usoro ọgwụgwọ ahụ dum. Nke a metụtakwara ihe banyere ọrịa na-efe efe n'oge ọgwụgwọ ma ọ bụ mgbanwe na ụzọ ndụ ndị ọrịa.

Ihe mgbaàmà ahụ nke hypoglycemia nke na-egosipụta adrenergic counterregulation nke anụ ahụ na nzaghachi hypoglycemia (lee akụkụ “Mmetụta akụkụ”) nwere ike ịdị nro ma ọ bụ ghara ịdị na-eji nwayọ nwayọ nke hypoglycemia, na ndị ọrịa merela agadi, ndị ọrịa nwere akwara autonomic neuropathy, ma ọ bụ ndị ọrịa na-anata beta. -adrenoblockers, clonidine, reserpine, guanethidine na ndị ọrụ ebere ndị ọzọ nwere ọmịiko.

Enwere ike iwepụ hypoglycemia ngwa ngwa site na ntinye nke carbohydrates ngwa ngwa digoseble (glucose ma ọ bụ sucrose).

Dị ka ọ dị na ihe ndị ọzọ na-eme ka sulfonylurea, n'agbanyeghị nnwere onwe mbido nke hypoglycemia, hypoglycemia nwere ike ịmaliteghachi. Ya mere, ndị ọrịa kwesịrị ịdị na-elekọta ha mgbe niile.

Na nnukwu hypoglycemia, ọgwụgwọ ozugbo na nlekọta ahụike, na n'ọnọdụ ụfọdụ, ịga ụlọ ọgwụ onye ọrịa, ka a chọrọ.

N'oge ọgwụgwọ glimepiride, a na-achọ nlele anya nke ọrụ imeju na foto ọbara oke (ọkachasị ọnụọgụ nke leukocytes na platelet).

Ebe ụfọdụ mmetụta ụfọdụ, dị ka oké hypoglycemia, mgbanwe dị ukwuu na foto ọbara, mmeghachi omume nfụkasị ahụ, mmebi imeju, nwere ike itinye ndụ n'ihe egwu ụfọdụ, ọ bụrụ na mmepe nke ihe na-adịghị mma ma ọ bụ mmeghachi omume siri ike, onye ọrịa ahụ kwesịrị ịgwa dọkịta na-aga ya ozugbo banyere ya ọ bụghị. n'ọnọdụ nke ọ bụla, akwụsịla ị theụ ọgwụ ahụ na-akwadoghị ya.

Mmetụta ikike ịkwọ ụgbọala na usoro ndị ọzọ. N'ihe banyere mmepe nke hypoglycemia ma ọ bụ hyperglycemia, karịsịa na mmalite nke ọgwụgwọ ma ọ bụ mgbe mgbanwe ọgwụgwọ, ma ọ bụ mgbe a naghị a takenụ ọgwụ ahụ mgbe niile, mbelata nlebara anya na ọsọ nke mmeghachi omume psychomotor. Nke a nwere ike imebi ikike onye ọrịa ịnya ụgbọ ma ọ bụ usoro ndị ọzọ.

Emeputa

Sanofi-Aventis Deutschland GmbH, Germany, nke Sanofi-Aventis S.p.A rụpụtara. (Tali).

Stabilimento di Scoppito, Strada Statale 17, km 22, I-67019 Scoppito (L "Aquilla), Italy.

Ọ dị mkpa ịmata! Ihe ohuru ohuru nke ndi endocrinologists gwara maka Nyochaa Ọrịa Shuga Na-aga n'ihu! Ọ bụ naanị na ọ dị mkpa kwa ụbọchị.

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

Ọrịa shuga bụ ihe na-akpata ihe fọrọ nke nta ka ọ bụrụ 80% nke ọrịa strok na mgbatị niile. 7 n’ime mmadụ 10 n’ime mmadụ na-anwụ n’ihi akwara mkpụrụobi ma ọ bụ ụbụrụ nwere oghere.N'ihe fọrọ nke nta ka ọ bụrụ okwu niile, ihe kpatara njedebe a dị oke egwu bụ otu - shuga dị n'ọbara.

Enwere ike ịkwatu shuga, ma ọ bụghị. Mana nke a anaghị agwọ ọrịa ahụ n'onwe ya, kama ọ na - enyere aka ịlụ ọgụ nyocha, ọ bụghị ihe kpatara ọrịa ahụ.

Naanị ọgwụ a na-atụ aro maka ịgwọ ọrịa shuga yana ndị endocrinologists na-ejikwa ya n'ọrụ ha.

Ofgwọ ọgwụ dị irè, gbakọọ dịka usoro ọkọlọtọ (ọnụọgụ ndị ọrịa ndị gbakere na ọnụọgụ ndị ọrịa nọ n’otu narị mmadụ 100 e si nweta ọgwụgwọ) bụ:

Normalization shuga - 95%
Mwepu nke akwara mbufụt - 70%
Mwepu nke obi ike - 90%
Bibie ọbara mgbali elu - 92%
Ime ka ubochi di elu, meghari ura n'abali - 97%

Ndị na-emepụta abụghị ụlọ ọrụ azụmahịa ma na-enweta nkwado na steeti. Ya mere, ugbu a onye obibi ọ bụla nwere ohere.

Nri nke ha n takeweta nkpuru kwesiri ogwu riri nne,
Na agbanyeghị ị kwesịrị ịmaba nri. Ọ bụrụ na ịnweghị nri ụtụtụ, a na-atụgharị oriri Amaril na nri ehihie,
Ọ dị mkpa ịhazi otu oriri nke carbohydrates n'ime ọbara. Emezuru ebumnuche a site na nri ugboro ugboro (mgbe awa anọ gasịrị), nkesa nke carbohydrates na efere niile. Nri nri dị obere, ọ dị mfe karịa ịnweta ụgwọ afọ ọria mamịrị.

Amaril na-ailụbiga mmanya ókè ruo ọtụtụ afọ na-enweghị oge izu. Ọ bụrụ na oke kachasị akwụsịla iji belata shuga, ngwa ngwa ọ dị mkpa ka ịgbanwere ọgwụ insulin.

Oge ihe omume

Amaryl nwere bioavailability zuru oke, 100% nke ọgwụ ahụ rutere ebe a na-eme ya. Dịka ntuziaka ahụ si dị, etolite mkpokọta glimepiride n'ime ọbara bụ mgbe awa 2.5 gachara. Oge ngụkọta oge a na-eme ihe karịrị awa iri abụọ na anọ, nke ka elu a do doụ, yabụ mbadamba Amaril dị ogologo ga-arụ ọrụ.

N'ihi ogologo oge ọ na-ekwe, a na-ahapụ ọgwụ a otu ugboro n'ụbọchị. Nyere na 60% nke ndị ọrịa mamịrị anaghị enwe oke ịgbaso ntuziaka dọkịta, otu dose nwere ike belata omission ọgwụ site na 30%, ya mere melite usoro nke ọrịa shuga.

Ihe ngbanwe

Onwere ndepụta nke contraindication buru ibu maka iwere Amaril:

Dị 1
imebi oke nke imeju na akụrụ,
ọrịa mamịrị ketoacidosis, precoma na coma,
, ,
ọnụnọ ọrịa dịkarịsịrị ala, dịka ọmụmaatụ, ịkpa ókè galactose, glucose-galactose malabsorption ma ọ bụ ụkọ lactase,
afọ ụmụaka
anabataghị ikike ma ọ bụ uche nke ọgwụ na ihe ndị ọzọ.

Achọrọ ịkpachara anya na mmalite nke ọgwụgwọ nke ndị ọrịa, ebe ọ bụ na n'oge a, enwere ihe ize ndụ nke hypoglycemia. Ọ bụrụ na enwere ike ịmalite hypoglycemia na-aga n'ihu, mgbe ahụ ị ga-emegharị dose ahụ mgbe mgbe glimepiride ma ọ bụ usoro ọgwụgwọ. Na mgbakwunye, ọnụnọ nke mgbochi na ọrịa ndị ọzọ, ụdị ndụ, nri na ihe ndị ọzọ chọrọ nlebara anya pụrụ iche.

Ntụziaka maka Amaryl (Usoro na usoro onunu ogwu)

Emebere mbadamba ihe ndị a maka ihe niile dị na ya, na-enweghị ị cheụ mmiri na ị drinkingụ ọtụtụ mmiri.

N ’oge a, ọnụọgụ ọgwụ ahụ kpebisiri ike n’ọbara site n’ọbara nke glucose n’ọbara. Maka ọgwụgwọ, a na-enye ọgwụ dịkarịsịrị ala, nke na-enyere aka inweta njikwa metabolic dị mkpa

Ntụziaka maka ojiji nke Amaril na-emekwa ka a mata na n’oge ọgwụgwọ, mkpebi nke itinye glucose n'ọbara yana ọkwa glycosylated haemoglobin dị mkpa.

Iri mbata ọ bụla, na ịpụ ọzọ, anaghị atụ aro ka iji nwetinye ya ọzọ. Ọnọdụ ndị dị otú ahụ kwesịrị ka ekwenye n'ihu dọkịta na-ahụ maka ịga.

Na mbido ọgwụgwọ, a na-enye ndị ọrịa ọgwụ kwa ụbọchị nke 1 mg. Ọ bụrụ na ọ dị mkpa, a na-eji nwayọ nwayọ nwayọ, na-arụ ọrụ nlebara anya mgbe niile maka ịgwọ glucose ọbara dị ka atụmatụ: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg - 8 mg.Usoro ọgwụgwọ a na-eme kwa ụbọchị na ndị ọrịa nwere ezigbo njikwa bụ 1-2 mg nke ihe na-arụ ọrụ. Kwa ụbọchị nke 6 mg ma ọ bụ karịa na-arụpụta ihe ọ bụ naanị na ọnụ ọgụgụ dị nta nke ndị ọrịa.

Ọ bụ dọkịta na-esetịpụrụ usoro usoro ọgwụ kwa ụbọchị nke ọgwụ ahụ, ebe ọ dị mkpa iburu n'uche ọtụtụ ihe, dịka ọmụmaatụ, oge iri nri, oke mmega ahụ, yana ndị ọzọ.

Ọtụtụ mgbe, a na-enye ọgwụ otu ụbọchị ị dailyụ ọgwụ, tupu nri ụtụtụ zuru ezu ma ọ bụ nri nri mbụ. Ọ dị mkpa na iri mbadamba mbadamba ịhapụ nri.

A maara na imeziwanye usoro metabolic nwere njikọ na ịba ụba nke insulin, yana n'oge ọgwụgwọ, mkpa maka glimepiride nwere ike iju. Enwere ike ịhapụ hypoglycemia site na mbenata usoro onodu oge ya ma ọ bụ site na ịkwụsị Amaril.

N'oge usoro ọgwụgwọ, mmezi usoro onunu ogwu glimepiride nwere ike iru mgbe:

mbelata ibu
ndụ ya agbanwe
ihe omume ndị ọzọ na - ebute bute ọrịa hypoglycemia ma ọ bụ hyperglycemia.

Dịka iwu, a na-eme ọgwụgwọ Amaril ogologo oge.

Usoro ahia

N’ebe a na-ere ọgwụ, ịnwere ike inweta Amaryl ma ọ bụrụ na ịnwere ọgwụ n’aka dọkịta gị.

Atụmatụ nchekwa

Ekwesịrị idobe mbadamba ihe ndị a glimepiride n'ebe gbara ọchịchịrị, chebe ya site na ìhè anyanwụ kpọmkwem, ebe ụmụaka agaghị eru. Oge nchekwa - ka +30 о С.

Exbọchị mmebi

Jiri ọgwụ a maka ọnwa 36 ka ahapụpụtara.

Costgwọ nke Glimepiride Canon, nke Canonfarm mepụtara, dị obere. A na-ewere ọnụahịa nke ngwugwu nke mbadamba 30 nke 2 mg 2 dị ọnụ ala, ọ bụ 154 p.

Mmanya na Amaryl

Ọ gaghị ekwe omume ịkọ tupu mmanya na-egbu mmanya ga-emetụta onye na-a drugsụ ọgwụ ọjọọ dabere na glimepiride. Mmanya na-egbu egbu nwere ike ịkụda ma ọ bụ kwalite mmetụta hypoglycemic nke Amaril. Ya mere, enweghi ike iju ha n'otu oge.

Ekwesịrị ịgwọ hypoglycemic ogologo oge. N'ihi nke a, mmachibido iwu ị ofụ mmanya nwere ọtụtụ mmanya na - abụ nsogbu.

Ime ime, lactation

Aremụ nwanyị dị ime na-agafere insulin. Enwere ike iwepu ihe puru iche na ogwu ojoo uto na umuaka na utero ma oburu na i hapuru sulfonylurea na ngbanye izu ime.

N'oge a na-enye nwa ara, amachibidoro ọgwụgwọ Amaril.Ihe dị n’ime ahụ na-abanye n’ime mmiri ara, anụ ahụ nwa amụrụ ọhụrụ. Mgbe ị na-enye nwa ara, ọ dị mkpa na nwanyị ahụ ga-agbanwerịrị ọgwụ insulin kpamkpam.

Ọrịa shuga na-arịa insulin na-abụghị insulin

Ngwakọta na ụdị ntọhapụ

na ngwugwu bliri nke 15 PC., na ngwugwu kaadiboodu 2, 4, 6 ma ọ bụ 8.

Nkọwa nke ụdị usoro onunu ogwu

Amaryl 1 mg: mbadamba pink, oblong, larịị nke nwere ahịrị na abụọ. Kanyere “NMK” ma meekwa “h” n’akụkụ abụọ.

Amaryl 2 mg: mbadamba nkume akwụkwọ ndụ akwụkwọ ndụ, okpukpu kwee, larịị nke nwere ahịrị na akụkụ abụọ. Kanyere “NMM” ma meekwa “h” n’akụkụ abụọ.

3 Amaryl 3 mg: mbadamba nkume na-acha edo edo na-acha odo odo, na-acha uhie uhie, dị larịị nke nwere ahịrị na akụkụ abụọ. Kanyere “NMN” ma meekwa “h” n’akụkụ abụọ.

Amaryl 4 mg: mbadamba nkume na-acha anụnụ anụnụ, oblong, ewepụghị na akara nkewa na akụkụ abụọ. Kanyere “NMO” ma meekwa “h” n’akụkụ abụọ.

Njirimara

Ọrịa hypoglycemic maka nchịkwa ọnụ nke sistemu nke sulfonylurea nke ọgbọ nke atọ.

Omume ọgwụ

Mlọ ọgwụ

Mgbe otu glimepiride, otu ụzọ n'ime 58% nke ọgwụ ahụ bụ akụrụ na 35% nke dose site na eriri afọ. Achọpụtaghị glimepiride na mmamịrị ahụ.

Glimepiride na-apụ apụ na mmiri ara ara ma na-agafe ihe mgbochi placental.

Mlọ ọgwụ

Glimepiride na-ebelata mkpụkọ glucose n'ime ọbara, tumadi n'ihi mkpali nke ntọhapụ nke insulin na sel beta nke pancreas. Nsonaazụ ya jikọtara ya na nkwalite ike nke mkpụrụ ndụ beta nke na - emeghachi omume na - eme ka mmeghachi omume physiological nwere glucose.Tụnyere glibenclamide, ị doụ glimepiride dị ala na-akpata mwepụta nke insulin obere obere ebe ị na-enweta ihe dị ka otu mbelata n'ọbara glucose ọbara. Eziokwu a na-agba akaebe na ọnụnọ nke extrapancreatic hypoglycemic mmetụta na glimepiride (mmụba anụ ahụ na insulin na mmetụta insulinomimetic).

Nsonaazụ nke ịba ụba nke anụ ahụ na insulin. Glimepiride na - akwalite nsonaazụ insulin na nnweta nke glucose site na uru anụ ahụ dị n'akụkụ.

Mmetụta insulinomimetic. Glimepiride nwere mmetụta yiri nke insulin na nnweta nke glucose site na akwara akụkụ yana ịhapụ glucose site na imeju.

Glimepiride na-egbochi mwepu nke glucose site na imeju site na ịbawanye ụba nke fructose-2,6-bisphosphate, nke na-egbochi gluconeogenesis.

Ọkpụkpụ akụrụngwa. Site na channelụ potassium na-emetụta ụbụrụ ATP (lee anya), sulfonylureas nwekwara mmetụta na sistem. N'iji ya na usoro ọdịnala sulfonylurea, glimepiride nwere mmetụta dị ala na sistem ụbụrụ. Ọ na - ebelata platelet na - eduga na mbelata dị egwu na njeri nke atherosclerotic plaques.

Jiri na umuaka. Enweghị data banyere ịdịte aka na nchekwa ogologo oge mgbe ị na-eji ọgwụ ahụ na ụmụaka.

Elldị shuga abụọ nke ọrịa shuga (na monotherapy ma ọ bụ dịka akụkụ nke ọgwụgwọ njikọta na metformin ma ọ bụ insulin).

Ihe ngbanwe

hypersensitivity na glimepiride ma ọ bụ ihe ọ bụla inyeaka nke ọgwụ ahụ, ọgwụ ndị ọzọ na-akpọ sulfonylurea ma ọ bụ ọgwụ sulfa (ihe egwu nke mmeghachi omume hypersensitivity),

ụdị shuga 1

ọrịa mamịrị ketoacidosis, precca mamịrị shuga,

nnukwu ọrịa imeju (enweghị ahụike na ahụike)

nnukwu nsogbu gbasara akụrụ, tinyere na ndị ọrịa na-anagide usoro ịba uru (enweghị ahụike na ahụike)

afọ ụmụaka (enweghi ahụmịhe na ahụike),

Ọrịa na - adịghị ahụkebe ọrịa dịka ụyọkọ galactose, ụkọ lactase ma ọ bụ ọrịa glucose-galactose malabsorption.

Ọnọdụ izu ụka mbụ nke ọgwụgwọ (ohere ịba ụba nke hypoglycemia). Ọ bụrụ na enwere ihe ndị dị ize ndụ maka mmepe nke hypoglycemia (lee akụkụ "Ntuziaka Pụrụ Iche"), ịchọrọ ịhazigharị glimepiride ma ọ bụ ọgwụgwọ ahụ dum,

oria intercurrent n'oge ọgwụgwọ ma ọ bụ mgbe ịgbanwe ndụ ndị ọrịa (mgbanwe na nri na oriri, mmụba ma ọ bụ ibelata mmega ahụ),

malabsorption nke nri na ọgwụ ike na nri diges (mgbochi afọ, eriri afọ paresis).

Ime na lactation

A na-enyefe ihe dị n’ime ụmụ nwanyị dị ime. N'ihe dị ime tụwara ime ma ọ bụ mmalite nke afọ ime, a ga-agafara nwanyị na insulin ọgwụ.

Glimepiride na-abanye n’ime mmiri ara, ya mere, enweghị ike ị takenụ ya n’oge a na-enye ya ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

Nsonaazụ

Site n'akụkụ nke metabolism: n'ihi nsonaazụ hypoglycemic nke Amaril, hypoglycemia nwere ike ịmalite, nke, dịka ọ nwere ike ịdị ogologo oge, ọ nwere ike ịgbatị oge.

Ihe mgbaàmà hypoglycemia bụ: isi ọwụwa, agụụ, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, ụra, nchekasị ụra, nchekasị, oke iwe, ntị na-adịghị mma, ịmụrụ anya na ọsọ nke mmeghachi omume, ịda mba, ọgba aghara, ọgba aghara okwu, aphasia, ọgba aghara visual, oke ịma jijiji, paresis, nsogbu uche, nkụda mmụọ, ọnwụ nke njide onwe onye, nchekasị nke ụbụrụ, inwe obi abụọ ma ọ bụ ọnwụ nke mmụọ, ruo na coma, iku ume na-emighị emi, bradycardia.

Na mgbakwunye, ngosipụta nke nchịkwa adrenergic nwere ike ime na nzaghachi hypoglycemia, dị ka ọdịdị nke oyi, ọsụsọ nnya anwụ, nchekasị, tachycardia, ọbara mgbali akwara, angina pectoris, palpitations, na ọgba aghara obi.

Ngosiputa ogwu a banyere aru ike hypoglycemia nwere ike buru oria. Ọrịa hypoglycemia fọrọ nke nta ka ọ na-apụ n'anya mgbe ọ kwụsịrị.

Site n'akụkụ akụkụ ahụ nke ọhụụ: n'oge ọgwụgwọ (ọkachasị na mbido ya), enwere ike ịhụ nsogbu anya na-adịghị ala ala n'ihi mgbanwe nke mkpokọta glucose na ọbara. Ihe kpatara ha bụ mgbanwe nwa oge na nbịpụta nke oghere ahụ, dabere na nchịkọta glucose dị n'ọbara, na n'ihi nke a, mgbanwe mgbanwe ndebanye nke oghere ahụ.

Site na eriri afọ: n'ime obere oge - ọgbụgbọ, ọgbụgbọ, mmetụta nke ibu ma ọ bụ jupụta na epigastrium, mgbu afọ, afọ ọsịsa, n'ọnọdụ ụfọdụ - ịba ọcha n'anya, ụba ọrụ nke enzymes imeju na / ma ọ bụ cholestasis na jaundice, nke nwere ike ịbawanye na ọrịa imeju na-eyi ndụ egwu. , mana ị nwere ike ịnwe mmepe mgbanwe mgbe ị kwụsịrị ọgwụ ahụ.

Site na sistem haemopoietic na lymphatic system: adịkarịghị - thrombocytopenia, n'ọnọdụ ụfọdụ - leukopenia, hemolytic anaemia, erythrocytopenia, granulocytopenia, agranulocytosis na pancytopenia.

Nsogbu izugbe: n’ọnọdụ ndị a na-adịghị ahụkebe, nfụkasị ahụ na mmeghachi ahụ nfụkasị, dị ka itching, urticaria, ọnya ọnya, ga-ekwe omume. Mmeghachi omume ndị dị otú ahụ nwere ike ịba na mmeghachi omume siri ike na mkpụmkpụ ume, mbelata ọbara mgbali elu, nke nwere ike ịga n'ihu na ujo anaphylactic mgbe ụfọdụ. Ọ bụrụ na mgbaàmà nke urticaria apụta, kpọọ dọkịta ozugbo. N'ọnọdụ ụfọdụ, enwere ike belata mbelata nke sodium kasịnụ, vasculitis nfụkasị, fotoensitivity.

Mmekorita

Glimepiride bụ cytochrome P4502C9 (CYP2C9), nke ekwesiri iburu n'uche mgbe ejiri ya mee ihe n'otu oge na ntinye (dịka. Rifampicin) ma ọ bụ inhibitors (dịka ọmụmaatụ fluconazole) CYP2C9.

Enweghi ike nke hypoglycemic edinam na, n'ọnọdụ ụfọdụ, enwere ike ịhụ mmepe nke hypoglycemia metụtara nke a mgbe ejikọtara ya na otu n'ime ọgwụ ndị a: insulin na ndị ọzọ hypoglycemic na-elekọta maka nchịkwa ọnụ, ACE inhibitors, anabolic steroids na nwoke mmekọahụ, chloramphenicol, cumarin derivide, cyclopho , fenfluramine, pheniramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAO inhibitors, fluconazole, para-aminosalicylic acid, pentoxifylline (parenteral dị elu s dose), phenylbutazone, azapropazone, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, clarithromycin, sulfonamides, tetracyclines, tritokvalin, trofosfamide.

Mwepu nke mmetụta hypoglycemic na mmụba metụtara njikọta glucose ọbara, enwere ike ịhụ ya na otu n'ime ọgwụ ndị na-esote: acetazolamide, barbiturates, GCS, diazoxide, diuretics, epinephrine na ndị ọzọ na-enye nkwado, glucagon, laxatives (ya na iji ogologo oge), nicotinic acid (na oke doses), estrogens na progestogens, phenothiazines, phenytoin, rifampicin, homonụ thyroid nwere.

Ndị na - egbochi ndị na - anabata ọgwụ H 2 histamine, beta-igbochi, clonidine na reserpine na - enwe ike ịkwalite ma wedata ike hypoglycemic nke glimepiride. N'okpuru mmetụta nke ndị na - eme ebere, dị ka beta-igbochi, clonidine, guanethidine na reserpine, akara nke adrenergic counterregulation na nzaghachi hypoglycemia nwere ike belata ma ọ bụ anọghị ya.

Na nzụlite glimepiride, enwere ike ịhụbawanye ma ọ bụ na-akụda mmụọ nke ihe ndị sitere na coumarin.

Otu ị orụ mmanya na-egbu egbu ma ọ bụ nke na-adịghị ala ala nwere ike ịkwalite ma wedata ike hypoglycemic nke glimepiride.

Dodoụbiga ya ókè

Mgbaàmà: oke ịdoụbiga ọgwụ ókè, yana ọgwụgwọ ogologo oge yana oke glimepiride dị oke elu, nwere ike ibute hypoglycemia na-egbu ndụ.

Ọgwụ: Ozugbo achọpụtara oke mmịnye ọbara, ị ga-agwa dọkịta gị ozugbo. Enwere ike ịkwụsị hypoglycemia mgbe niile ngwa ngwa oriri nke carbohydrates ozugbo (glucose ma ọ bụ otu shuga, ihe ọ fruitụ fruitụ mkpụrụ osisi ma ọ bụ tii). N'akụkụ a, onye ọrịa ahụ kwesịrị inwe ma ọ dịkarịa ala 20 g glucose (iberibe shuga 4). Ndị na-atọ ụtọ ụtọ anaghị arụ ọrụ na ọgwụgwọ hypoglycemia.

Ruo mgbe dọkịta kpebiri na ọrịa adịghị n'ihe ize ndụ, onye ọrịa ahụ chọrọ nlekọta ahụike nke ọma. Ekwesiri icheta na hypoglycemia nwere ike ịmaliteghachi mgbe mweghachi mbụ nke mkpokọta glucose dị n'ọbara.

Ọ bụrụ na ndị dọkịta dị iche iche na-agwọ onye ọrịa na-arịa ọrịa shuga (dịka ọmụmaatụ, n'oge ọnụnọ ụlọ ọgwụ mgbe ihe ọghọm, na-arịa ọrịa na ngwụsị izu), ọ ga-agwa ha banyere ọrịa ya na ọgwụgwọ mbụ.

Oge ụfọdụ ịnwere ike ịga ụlọ ọgwụ onye ọrịa ahụ, ọbụlagodi na ọ bụrụ naanị na ọ ga-akpachapụ anya. Nnukwu ịdoụbiga mmanya ókè na mmeghachi omume siri ike na ngosipụta dịka ọnwụ nke mmụọ ma ọ bụ nsogbu akwara ozi ndị ọzọ dị njọ bụ ọnọdụ ahụike chọrọ ngwa ngwa ma chọọ ọgwụgwọ na ụlọ ọgwụ ozugbo.

N'ihe banyere ọnọdụ amaghị onye ọrịa, ọgwụ ntụtụ dị mkpa nke dextrose (glucose) dị mkpa (maka ndị okenye, na-amalite na 40 ml nke ihe ngwọta 20%). Dika uzo ozo diri ndi okenye, nnabata, Subcutaneous ma obu intramuscular nke glucagon ga ekwe omume, ima atu, na uzo 0,5-1 mg.

Na usoro ọgwụgwọ hypoglycemia n'ihi njikwa mberede nke Amaril site na ụmụ aka ma ọ bụ ụmụaka, a ga-eji nlezianya dozie ọgwụ dextrose na-achịkwa ma enwere ike hyperglycemia dị ize ndụ, na nchịkwa nke dextrose kwesịrị ịdị na-eleba anya mgbe niile maka ịta ọbara glucose ọbara.

Ọ bụrụ na ị Amarụbiga mmanya ókè nke Amaril, ọ nwere ike ịdị mkpa ịsacha afọ ma were unyi na-arụ ọrụ.

Mgbe eweghachiri glucose dị n'ọbara ngwa ngwa, nnweta mkpụkọ nke usoro dextrose na mkpụmkpụ ọ dị mkpa iji gbochie ịmaliteghachi hypoglycemia. Ekwesịrị ilebara mkpokọta glucose ọbara n'ọbara n'ime ndị ọrịa dị otú ahụ ruo awa 24. N'ọnọdụ ndị dị njọ na usoro hypoglycemia dị ogologo, ihe ize ndụ nke iwetulata glucose n'ọbara n'ọbara hypoglycemic nwere ike ịdịgide ruo ọtụtụ ụbọchị.

Usoro onunu ogwu na nhazi

N'ime, kpamkpam, na-enweghị ata ata, na-eji mmiri mmiri asachapụ (ihe dị ka iko 0,5).

Dịka iwu, a ga-ekpebi dose nke Amaril site na itinye uche nke glucose n'ọbara. O kwesiri iji obere ọgwụ zuru ezu iji nweta ihe nchịkwa metabolic dị mkpa.

Mgbe a na-emeso ya na Amaril, ọ dị mkpa ikpebi oge niile glucose nke ọbara. Na mgbakwunye, a na-atụ aro maka ilele hemoglobin nke glycosylated.

Iụ ọgwụ ọperụperụ na-ezighi ezi, dịka ọmụmaatụ, ịgafe ọgwụ ọzọ, agaghị agara gị agbanye ọzọ site na ị theụ ọgwụ ọzọ na-esote ya.

Omume onye ọrịa bụrụ nke njehie mgbe ị na-a theụ ọgwụ ahụ (karịchaa, mgbe ịpụghị ọgwụ ọzọ ma ọ bụ na-ahapụ nri) ma ọ bụ n'ọnọdụ ebe ọ na-agaghị ekwe omume ị theụ ọgwụ ahụ ka onye ọrịa ahụ na onye dọkịta ahụ kwurịtara tupu oge ahụ.

Usoro izizi na nhọrọ ịhọrọ ya

Ọgwụ nke mbụ bụ 1 mg nke glimepiride 1 oge kwa ụbọchị.

Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ubochi kwa ụbọchị (na oge nke izu 1-2). A na-atụ aro ka a na-eme ka mmụba ahụ na-arụ ọrụ mgbe niile na-eleba anya n'ọbara glucose ọbara yana dabere na usoro mmụba na-eso: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg (−8 mg).

Usoro onunu ogwu di n’ime ndi obia nwere oria a na-achịkwa nke oma

Dị ka ọ na-adịkarị, kwa ụbọchị maka ndị ọrịa nwere ọrịa shuga na-achịkwa nke ọma bụ 1-4 mg glimepiride. Aụ ọgwụ kwa ụbọchị nke ihe karịrị 6 mg dị irè karịa naanị ntakịrị ndị ọrịa.

Ọ bụ dọkịta kpebiri oge oge ị theụ ọgwụ na nkesa ọgwụ dị ka ụbọchị, dabere na ndụ onye ọrịa na oge enyere (oge nri, ọnụọgụ mmega ahụ).

Ọtụtụ mgbe, otu ọgwụ ọgwụ n’ụbọchị ezuru. A na-atụ aro na n'ọnọdụ a, a ga-ewere ọgwụ dum ọgwụ ahụ ozugbo nri ụtụtụ zuru oke ma ọ bụ, ọ bụrụ na a notaghị ya n'oge ahụ, ozugbo tupu nri nri mbụ. Ọ dị ezigbo mkpa ịhapụ isi nri mgbe ị gachara mbadamba.

Ebe ọ bụ na a na-ejikọta njikwa metabolism na ụba insulin na-arịwanye elu, mkpa nke glimepiride nwere ike ibelata n'oge ọgwụgwọ. Iji zere mmepe nke hypoglycemia, ọ dị mkpa iji belata dose ahụ n'oge ma ọ bụ kwụsị ị Amarụ Amịil.

Ọnọdụ enwere ike ịchọ mmezigharị nke glimepiride:

Nnukwu ibu na onye ọrịa

Mgbanwe na ndụ onye ọrịa (mgbanwe nri, oge nri, oge ọrụ ya),

Ọpụpụ nke ihe ndị ọzọ na - eduga na ọnọdụ ga - eduga na mmepe nke hypoglycemia ma ọ bụ hyperglycemia (lee akụkụ "ntuziaka pụrụ iche").

A na-arụkarị glimepiride ogologo oge.

Nyefee onye ọrịa site na onye ọzọ hypoglycemic na-elekọta maka nchịkwa ọnụ na Amaryl

Enweghị ezi mmekọrịta dị n'etiti usoro nke Amaril na ndị ọzọ hypoglycemic na-elekọta maka nchịkwa ọnụ. Mgbe ejiri dochie hypoglycemic ọzọ maka nchịkwa ọnụ na Amaril, a na-atụ aro na usoro maka nchịkwa ya bụ otu ihe ahụ na nchịkwa nke Amaril, i.e. ọgwụgwọ kwesịrị ịmalite site na obere ọgwụ nke 1 mg (ọbụlagodi na a na-ebugharị onye ọrịa ahụ na Amaryl na oke ọgwụ hypoglycemic ọzọ maka nchịkwa ọnụ). Mmụba ọ bụla kwesịrị ịdị na nkebi, na-eburu n'uche mmeghachi omume glimepiride dabere na ndụmọdụ ndị dị n'elu.

Ọ dị mkpa iburu n'uche ike na oge nke nsonaazụ hypoglycemic gara aga maka nchịkwa ọnụ. Enwere ike ịchọ nkwụsị ọgwụgwọ iji zere mkpokọta mmetụta ọ bụla nwere ike ịbawanye ohere nke hypoglycemia.

Jiri na metformin mee ihe

N'ime ndị ọrịa nwere ọrịa mellitus na-achịkwa nke ọma, mgbe ị na-ewere ọgwụ kachasị nke glimepiride ma ọ bụ metformin, enwere ike ịmalite ọgwụgwọ na ngwakọta ọgwụ abụọ a. N'okwu a, usoro ọgwụgwọ gara aga na nke glimepiride ma ọ bụ metformin na-aga n'ihu n'otu ọkwa, na mgbakwunye nke metformin ma ọ bụ glimepiride na-amalite site na obere ala, nke a na-edozigharị dabere na ọkwa nke njikwa metabolic ruo ogo kachasị kwa ụbọchị.Usoro ọgwụgwọ agwakọtara kwesịrị ịmalite n’okpuru nlekọta ahụike.

Jiri yana insulin

N'ime ndị ọrịa nwere ọrịa mellitus na-achịkwa nke ọma, enwere ike inye insulin n'otu oge ahụ mgbe ị na-ewere glimepiride kachasị nke ụbọchị. N'okwu a, ọgwụ ikpeazụ glimepiride enyere onye ọrịa ahụ agbanwebeghị. N'okwu a, ọgwụgwọ insulin na-amalite site na usoro onyonyo dị ala, nke na-eji nwayọọ nwayọọ na-abawanye n'okpuru nchịkwa nke ịba ụba nke glucose n'ọbara. Ijikọtara ọgwụgwọ chọrọ nlekọta nlekọta ahụike nke ọma.

Jiri na ndị ọrịa nwere nsogbu gbasara akụrụ. Onweghi ihe omuma banyere iji ogwu a eme ihe n’ebe ndi oria no na ezughi oke. Ndị ọrịa nwere ọrụ mgbazinye nsogbu nwere ike ịdị na-elebara mmetụta hypoglycemic nke glimepiride (lee akụkụ "Pharmacokinetics", "Contraindications").

Jiri na ndị ọrịa nwere ọrịa imeju. Onweghi ihe omuma banyere uzo iji ogwu gha eme ihe (lee akuku "Contraindications").

Jiri na umuaka. Ihe omuma banyere iji ogwu eme ihe n’ime umuaka ezughi.

Ntụziaka pụrụ iche

N’ime izu izizi nke ọgwụgwọ, nsogbu nke ịba ụba hypoglycemia nwere ike ịbawanye, yabụ, achọrọ nlezianya ịbanye n’ọbara glucose na ọbara n’oge a.

Ihe ndi n’enye aka ibute oria obi shuga gụnyere:

Ọrịa ma ọ bụ enweghị ike nke onye ọrịa ahụ (nke a na-ahụkarị na ndị ọrịa agadi) ime ka dọkịta na-arụkọ ọrụ,

Erighị ihe na-edozi ahụ, iri nri na-adịghị agbanwe agbanwe ma ọ bụ na-ahapụ iri nri,

Enweghi ike n’etiti mmega ahu na oriri ndi ahu,

Alcoholụ mmanya na-egbu egbu, karịsịa na nri ndị ịpụsịrị ọnụ,

Nsogbu akwara na-enweghị nsogbu,

Ọrịa hepatic siri ike (na ndị ọrịa nwere nnukwu nsogbu ịba ọcha n'anya, a na-egosipụta nnyefe na ọgwụgwọ insulin, opekata mpe ruo mgbe a ga-enweta njikwa metabolic),

N'otu oge eji ụfọdụ ọgwụ (lee mpaghara “Mmekọrịta”),

Nnabata nke glimepiride na enweghị ihe ngosi maka nnabata ya.

Enwere ike iwepụ hypoglycemia ngwa ngwa site na ntinye nke carbohydrates ngwa ngwa digoseble (glucose ma ọ bụ sucrose).

Na nnukwu hypoglycemia, ọgwụgwọ ozugbo na nlekọta ahụike, na n'ọnọdụ ụfọdụ, ịga ụlọ ọgwụ onye ọrịa, ka a chọrọ.

N'oge ọgwụgwọ glimepiride, a na-achọ nlele anya nke ọrụ imeju na foto ọbara oke (ọkachasị ọnụọgụ nke leukocytes na platelet).

Emeputa

Sanofi-Aventis Deutschland GmbH, Germany, nke Sanofi-Aventis S.p.A rụpụtara. (Tali).

Stabilimento di Scoppito, Strada Statale 17, km 22, I-67019 Scoppito (L "Aquilla), Italy.

Ọ dị mkpa ịmata! Ihe ohuru ohuru nke ndi endocrinologists gwara maka Nyochaa Ọrịa Shuga Na-aga n'ihu! Ọ bụ naanị na ọ dị mkpa kwa ụbọchị.

Ntụziaka dị mkpirikpi

Ihe omume

Na-ebelata ọbara shuga, na-emetụta ọkwa ya n'akụkụ abụọ:

Na-akpali njikọ nke insulin, ma weghachite akụkụ mbụ, ngwa ngwa nke nzuzo ya. PSM ndị ọzọ fọdụrụnụ na -akwu oge a ma na-arụ ọrụ na nke abụọ, ya mere a na-ebelata shuga nwayọ nwayọ.
Na-ebelata insulin na-agbasi mbọ ike karịa PSM ndị ọzọ.

Na mgbakwunye, ọgwụ ahụ na-ebelata ihe ize ndụ nke thrombosis, na-eme ka cholesterol na-ebelata, na-ebelata nrụgide oxidative.

Amaryl apụtaghị akụkụ ya na mmamịrị, akụkụ ya site na mgbaze nri, yabụ enwere ike iji ya na ndị ọrịa nwere akụrụ gbasara akwara, ma ọ bụrụ na echekwaara akụrụ akụkụ ụfọdụ.

Ihe na-egosiỌrịa shuga naanị ụdị 2. Ihe a ga-eji mee ihe bụ ichebe mkpụrụ ndụ beta, nke a na-ejikọkwa na insulin nke onwe ha. Ọ bụrụ na pancreas akwụsịla imepụta homonụ, ekwenyeghị Amaril. Dịka ntuziaka ahụ si dị, a pụrụ iji ọgwụ ọgwụ metformin na insulin gwọ ọgwụ ya. Usoro onunu ogwu

A na-emepụta Amaryl n'ụdị mbadamba ụrọ nwere ihe ruru 4 mg nke glimepiride. Maka ịdị mfe nke iji, usoro ọ bụla nwere agba nke ya.

Usoro ịmalite bụ 1 mg. A na-ewere ya ruo ụbọchị iri, mgbe nke a gasịrị, ha na-amalite nwayọọ nwayọọ ruo mgbe shuga na-ahazi. Ogwu a kacha anabata bụ 6 mg.Ọ bụrụ na ọ kwaghị ụgwọ nkwụghachi ụgwọ maka ọrịa shuga, a na-agbakwunye ọgwụ ndị sitere na otu ndị ọzọ ma ọ bụ insulin na usoro ọgwụgwọ.

Dodoụbiga ya ókèExgabiga oke na-eduga na hypoglycemia dị ogologo. Mgbe usoro shuga kwusịrị, ọ nwere ike ịda ugboro ugboro maka ụbọchị 3 ọzọ. N'oge a niile, onye ọrịa ahụ kwesịrị ịnọ n'okpuru nlekọta nke ndị ikwu ya, ya na nnukwu ịdoụbiga mmanya ókè - ụlọ ọgwụ.Ihe ngbanwe

Hypersensitivity na-emeghachi omume na glimepiride na PSM ndị ọzọ, ihe inyeaka nke ọgwụ ahụ.
Enweghi insulin n’ime onwe (, yiri ihe puru iche).
Nnukwu gbasara akụrụ. Enwere ike ịnwe ọgwụ Amaril maka ọrịa akụrụ mgbe nyochachara akụkụ ahụ.
Glimepiride bụ metabolized na imeju, yabụ, imeju na-esonyekwa na ntuziaka ka contraindication.

Ewu nke hypoglycemia

Ọbara shuga na-ada ma ọ bụrụ na onye na-arịa ọrịa shuga chefuru iri nri ma ọ bụ ghara itinyeghachi glucose ahụ a na-eme n’oge a na-emega ahụ́. Iji mezie glycemia, ị kwesịrị ị toụ carbohydrates ngwa ngwa, ọ na-abụkarị shuga, iko ihe ọ juiceụ orụ ma ọ bụ tii dị ụtọ zuru ezu.

Ọ bụrụ na ọgwụ karịrị nke Amaril agafe, hypoglycemia nwere ike ịlaghachi ọtụtụ oge n’oge ọgwụ a. Na nke a, mgbe ha mechara shuga dị ka shuga, ha na-anwa wepu glimepiride na traktị nri: ha na-akpalite ọgbụgbọ, na-a adsụ adsorbents ma ọ bụ ọgwụ mgbu. Do overụbiga ihe ókè dị ukwuu na-egbu mmadụ; ịgwọ ọrịa hypoglycemia dị oké mkpa gụnyere glucose ọbara dị n’okpo ọbara.

NsonaazụNa mgbakwunye na hypoglycemia, mgbe ị na-ewere Amaril, enwere ike ịhụ nsogbu mgbaze (n'ihe na-erughị 1% nke ndị ọrịa), nfụkasị ahụ, sitere na nchapu na itching ruo ujo anacticlactic (8%). Mgbe akwụsịrị ụgwọ maka ọrịa ahụ, mkpa ọgwụ hypoglycemic na-ebelata, a na-akwụsịkwa Amaryl.

Ejiri nri a. . Enweghị ike ịkụpị mbadamba nkume ahụ, mana enwere ike ikewa ya abụọ na ihe egwu. Ọgwụgwọ Amaril chọrọ nrụzi maka ihe oriri:

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

Ọrịa shuga bụ ihe na-akpata ihe fọrọ nke nta ka ọ bụrụ 80% nke ọrịa strok na mgbatị niile. 7 n’ime mmadụ 10 n’ime mmadụ na-anwụ n’ihi akwara mkpụrụobi ma ọ bụ ụbụrụ nwere oghere. N'ihe fọrọ nke nta ka ọ bụrụ okwu niile, ihe kpatara njedebe a dị oke egwu bụ otu - shuga dị n'ọbara.

Enwere ike ịkwatu shuga, ma ọ bụghị. Mana nke a anaghị agwọ ọrịa ahụ n'onwe ya, kama ọ na - enyere aka ịlụ ọgụ nyocha, ọ bụghị ihe kpatara ọrịa ahụ.

Naanị ọgwụ a na-atụ aro maka ịgwọ ọrịa shuga yana ndị endocrinologists na-ejikwa ya n'ọrụ ha.

Normalization shuga - 95%
Mwepu nke akwara mbufụt - 70%
Mwepu nke obi ike - 90%
Bibie ọbara mgbali elu - 92%
Ime ka ubochi di elu, meghari ura n'abali - 97%

Ndị na-emepụta abụghị ụlọ ọrụ azụmahịa ma na-enweta nkwado na steeti. Ya mere, ugbu a onye obibi ọ bụla nwere ohere.

Nri nke ha n takeweta nkpuru kwesiri ogwu riri nne,
Na agbanyeghị ị kwesịrị ịmaba nri. Ọ bụrụ na ịnweghị nri ụtụtụ, a na-atụgharị oriri Amaril na nri ehihie,
Ọ dị mkpa ịhazi otu oriri nke carbohydrates n'ime ọbara. Emezuru ebumnuche a site na nri ugboro ugboro (mgbe awa anọ gasịrị), nkesa nke carbohydrates na efere niile. Nri nri dị obere, ọ dị mfe karịa ịnweta ụgwọ afọ ọria mamịrị.

Amaril na-ailụbiga mmanya ókè ruo ọtụtụ afọ na-enweghị oge izu.Ọ bụrụ na oke kachasị akwụsịla iji belata shuga, ngwa ngwa ọ dị mkpa ka ịgbanwere ọgwụ insulin.

Oge ihe omume

Mmanya ndakọrịta

Ihe ọcoụ actụ mmanya na-egbu egbu na-eme ihe banyere Amaril na-enweghị atụ, ha nwere ike ịkwalite ma wedata mmetụta ya. Ihe ize ndụ nke hypoglycemia na-abawanye, na-amalite site na ịerateụbiga mmanya ókè. Dabere na ndị ọrịa mamịrị, ọnụọgụ mmanya na-adịghị mma ọ dịghị ihe karịrị otu iko vodka ma ọ bụ iko mmanya .

Anaarila Amarila

Ọgwụ nwere ọtụtụ analogues dị ọnụ ala karịa nwere otu ihe na-arụ ọrụ na usoro onunu ogwu, nke a na-akpọ generics. N'ụzọ bụ isi, ndị a bụ mbadamba ihe eji emepụta ụlọ, site na ndị ebubata ị nwere ike ịzụta naanị Croatian Glimepirid-Teva. Dika ntuleta, analogues Russia adighi nma karia Amaril nke esi webata.

Anaarila Amarila	Obodo emeputa	Emeputa	Ọnụ ego maka usoro nke pere mpe, rub.
Glimepiride	Russia	110
Glimepiride Canon		Mmeputa Canonfarm.	155
Ibe edo edo		Akrikhin	180
Glimepiride-teva	Kroya	Pliva nke Khrvatsk	135
Glemaz	Ajentina	Kimika Montpellier	adịghị na ahịa ọgwụ

Amaryl ma ọ bụ ndị ọrịa mamịrị

Ugbu a, PSM kachasị ọhụrụ ma dị mma bụ glimepiride na ụdị gliclazide ogologo oge (yana analogues). Ọgwụ abụọ ahụ erughị ka ndị bu ha ụzọ ike ịkpata hypoglycemia siri ike.

Ma, mkpụrụ osisi Amaryl maka ọrịa shuga bụ ọkacha mma:

Dọkịta nke Sciences Medical, Isi nke Institute of Diabetology - Tatyana Yakovleva

M na-amụ ọrịa shuga kemgbe ọtụtụ afọ. Ọ na-atụ ụjọ mgbe ọtụtụ mmadụ nwụrụ, nweekwa nkwarụ karịa n'ihi ọrịa shuga.

Emere m ngwa ngwa izisa ozi ọma - Endocrinological Research Center nke Russian Academy of Medical Sciences jisiri ike mepụta ọgwụ na-agwọ ọrịa shuga kpamkpam. N'oge a, ịdị irè nke ọgwụ a na-eru nso 98%.

Ozi ọma ọzọ: Ministri Ahụike emeela nkuchi na-akwụ ụgwọ ụgwọ ọgwụ dị elu. Na Russia, ndị ọrịa mamịrị ruo Machị 2 nwere ike inweta ya - Naanị 147 rubles!

ha na-emetụta oke ibu nke ndị ọrịa belata
mmetụta ọjọọ na sistemụ akụrụngwa na-akpọghị aha,
ndị ọrịa shuga chọrọ obere ọgwụ ọgwụ (oke nke ịrịa ọrịa mamịrị dị ka 3 mg nke Amaril),
mbelata nke shuga mgbe ị na-ewere Amaril na-ebute mgbakwunye nke ọkwa insulin. Maka ndị ọrịa mamịrị, ogo a bụ 0.07, maka Amaril - 0.03. N'ime PSM fọdụrụ, rashụ ahụ ka njọ: 0.11 maka glipizide, 0.16 maka glibenclamide.

Amaryl ma ọ bụ Glucophage

N’ikwu ya hoo haa, ajụrụ Amaril ma ọ bụ Glucofage (metformin) ekwesighi ekwenye. yana analogues nke ụdị shuga 2 bụ nke a na-edekarị oge niile, ebe ha na-arụ ọrụ nke ọma karịa ọgwụ ndị ọzọ na-eme ihe kpatara isi ọrịa ahụ - nguzogide insulin. Ọ bụrụ na dọkịta depụtara naanị mbadamba amaryl, ya ike kwesịrị obi abụọ .

Amaril na Yanumet

Yanumet, dị ka Amaryl, na-emetụta ma ọkwa insulin na nguzogide insulin.Ọgwụ dị iche iche na usoro eji arụ ọrụ yana usoro kemịkalụ, yabụ enwere ike ijikọ ha. Yanumet bụ ọgwụ ọhụụ, yabụ na ọ na-efu site na 1800 rubles. nke kacha nta mkpọ. Na Russia, edepụtara aha ya: Combogliz na Velmetia, nke adịghị ọnụ ala karịa nke mbụ.

N'ọtụtụ oge, enwere ike ị nweta ụgwọ ụgwọ ọrịa shuga site na nchikota metformin dị ọnụ ala, nri, mmega ahụ, mgbe ụfọdụ ndị ọrịa chọrọ PSM. Yanumet bara uru ịzụta naanị ma ọ bụrụ na ọnụ ahịa ya adịghị mkpa maka mmefu ego.

Ndị na - arịa ọrịa mamịrị na usoro ọgwụgwọ edepụtara bụ isi ihe kpatara. Ibelata usoro ọgwụgwọ maka ọrịa ọ bụla na-adịghị ala ala na-eme ka nsonaazụ ya dị mma mgbe niile, ya mere, maka ndị ọrịa nhọrọ, a na-ahọrọ ọgwụ ngwakọta. Amaryl M nwere ngwakọta kachasị eji ọgwụ belata shuga: metformin na PSM. Mbadamba ụrọ nke ọ bụla nwere 500 mg nke metformin na 2 mg nke glimepiride.

Ọ gaghị ekwe omume idozi ma ihe arụ ọrụ niile n'otu mbadamba maka ndị ọrịa dị iche iche. N'etiti n'etiti ọrịa shuga, metformin ọzọ, ọ nwere obere glimepiride chọrọ. Anaghị anabata ihe karịrị 1000 mg nke metformin n'otu oge, ndị ọrịa nwere nnukwu ọrịa ga-a Amarụ mmanya Amaril M ugboro atọ n'ụbọchị. Iji họrọ etu usoro ọgwụgwọ ahụ siri dị, ọ ga-adị mma ka ndị ọrịa dọọ aka na ntị were ọgwụ gaa Kalail iche iche na nri ụtụtụ na Glucofage ugboro atọ n'ụbọchị.

Agbanyeghị, ọ bụghị onye ọ bụla nwere ike ị nweta ego nke hypoglycemic a. Ya mere, n'isiokwu a, a ga-ekpughe ọgwụ ọgwụ nke Amaril na aha analogues nke bụ isi na Russia.

Emere ọgwụ ọgwụ

Mainzọ kachasị eji arụ ọrụ na-akpali akpali bụ na Amaril na-eme ka ịbawanye uru nke sel beta na-abawanye na glucose n'ọbara mmadụ.

Na obere doses, ọgwụ a na-eme ka ntakịrị mmụba na ntọhapụ nke insulin. Amaryl nwere ikike ime ka mmetụta nke ihe ndị mejupụtara insulin na-akpata n’ime insulin.

Ọkpụkpụ glucose na-abanye n’ime mkpụrụ ndụ akwara nke anụ ahụ.

Mgbe ị na-eji usoro ọgwụgwọ na ngwakọta na metformin, ndị ọrịa na-enwe ọganihu na metabolic na-achịkwa ọkwa shuga n'ime ahụ.

Na-eduzi usoro ọgwụgwọ ọgwụgwọ yana injections insulin. A na-eji usoro nchịkwa a mee ihe n'ọnọdụ ebe ogo adịghị ike nke metabolic na-adịghị enweta mgbe ị na-ewere otu ọgwụ.Mgbe ị na-eme ụdị ọgwụ a maka ọrịa shuga mellitus, a chọrọ ọgwụ mmachi insulin nke insulin.

A na-eme ka ego nke insulin ji na ụdị ọgwụgwọ a belata.

Pharmacokinetics nke ọgwụ

Ihe eji aru oru eji eme ihe bu ihe eji eme ka aru banye n’ime mejuputara nke mmiri ara. Kedu nke na - egbochi ohere ị theụ ọgwụ n’oge afọ ime na inye nwa ara.

A na-eme metabolism nke ihe na-arụ ọrụ na akwara nke imeju. Isi isoenzyme tinyere aka na metabolism bụ CYP2C9. Na usoro nke metabolism nke kọmpụta nke bụ isi na-arụ ọrụ, etolite metabolites abụọ, nke na-esochi na feces na mmamịrị.

Ewepụta ọgwụ ahụ site akụrụ na oke 58% na ihe dịka 35% site na enyemaka nke eriri afọ. Achọpụtaghị ihe dị n'ọrụ ọgwụ ahụ na mmamịrị anaghị agbanwe agbanwe.

Dabere na nsonaazụ nke ọmụmụ a, achọtara na ọgwụ ọgwụ anaghị adabere na nwoke ma ọ bụ nwanyị na ọgbọ ya.

Njirimara nke ọgwụ a

Ọkachamara na-ahụ maka ọgwụgwọ na-enye onye ọrịa nwere ụdị shuga nke 2 ọgwụ Amaril mbadamba dị ka monotherapy ma ọ bụ mgbe ejikọtara ya na ndị ọrụ hypoglycemic.

Agbanyeghị, ị theụ ọgwụ ahụ anaghị egbochi ọfụma na nri kwesịrị ekwesị, nke na-ewepụ abụba na carbohydrates dị mfe, na ndụ dị gara gara.

Ntuziaka maka iji ọgwụ ahụ

Ndị ọrịa mamịrị nwere ezigbo glycemic na-a takeụ ọgwụ kwa ụbọchị nke ruru 4 mg.

mbelata ibu
gbanwee ụdị ndụ (nri, nrụgide, oge nri),
ihe ndi ozo.

Ọ dị mkpa ịgakwuru dọkịta ma malite na obere opekempe (1 mg) nke Amaril ma ọ bụrụ na onye ọrịa chọrọ:

dochie ọgwụ ọzọ eji eme ka shuga dị na Amaril,
Nchikota glimepiride na metformin,
Nchikota bu glimepiride na insulin.

Ọ baghị uru ị medicineụ ọgwụ maka ndị ọrịa nwere ọrịa gbasara akụrụ, yana ọrịa akụrụ na / ma ọ bụ ọrịa imeju.

Njere uto na mmeghachi omume ojoo

Amaril glimepiride dị na ọgwụ ahụ, yana akụkụ ndị ọzọ, anaghị enwe mmetụta dị mma mgbe niile n'ahụ ahụ onye ọrịa mamịrị.

Aszọ ndị ọzọ, ọgwụ nwere contraindications.

Amachibidoro ndị ọrịa ị pụ ọgwụ na ọnọdụ ndị a:

ofdị shuga insulin
oge ime na ara,
(imebi metabolism metabolism), ọnọdụ nke precca mamịrị shuga na coma,
ndị ọrịa na-erubeghị afọ 18,
ụyọkọ galactose, ụkọ lactase,
mmepe nke glucose-galactose malabsorption,
imebi imeju na akụrụ, ọkachasị ndị ọrịa na-ele ịba ọcha n'anya.
mmadu anagideghi ihe di n’ime ogwu ahu, nkari sulfonylurea, ndi na acho sulfonamide.

Site n'iji mbadamba eme ihe na-ekwesịghị ekwesị (dịka ọmụmaatụ, nnabata), mmeghachi omume siri ike nwere ike ịmalite:

Ọnọdụ hypoglycemic, akara nke ya bụ isi ọwụwa na nkụda mmụọ, ntị na-adịghị mma, oke iwe, ọgba aghara, ụra, ụjọ na-atụ, mkpọtụ, na ọhụhụ.
Usoro nchịkwa mgbochi nke Adrenergic dị ka nzaghachi maka mgbali glucose ngwa ngwa, gosipụtara nchekasị, palpitations, tachycardia, ọgba aghara nke obi na ọdịdị nke ọsụsọ oyi.
Ọgba aghara digestive - mkpọchi ọgbụgbọ, ọgbụgbọ, flatulence, abdominal pain, afọ ọsịsa, mmepe nke ịba ọcha n'anya, ụba ọrụ enzymes imeju, jaundice or cholestasis.
Mmebi nke usoro hematopoietic - leukopenia, thrombocytopenia, granulocytopenia na ụfọdụ ọrịa ndị ọzọ.
Allergy, gosipụtara site na rashes akpụkpọ, itching, hives, mgbe ụfọdụ anaphylactic ujo na vasculitis nfụkasị.

Mmeghachi omume ndị ọzọ ga - ekwe omume - photoensitization na hyponatremia.

Efu, nyocha na analogues

1 mg 30 mbadamba - 370 rub.,
2 mg 30 mbadamba nkume - 775 rubles.,.
3 mg 30 mbadamba - 1098 rub.,
4 mg 30 mbadamba nkume - 1540 rub.,

Banyere echiche nke ndị ọrịa mamịrị banyere ịdị irè nke ọgwụ, ha dị mma. Site na iji ọgwụ ogologo oge, ọkwa glucose na-alaghachi na nkịtị. Ọ bụ ezie na ndepụta ahụ nwere ọtụtụ nsonaazụ ndị ọ ga-ekwe omume, pasent nke ihe omume ha dị obere. Agbanyeghị, enwere nyocha ndị na-adịghị mma gbasara ndị ọrịa metụtara ọnụ ahịa ọgwụ dị elu.Ọtụtụ n'ime ha ga-achọ nnọchi ndị Amaril.

Otu mbadamba ọgwụ ahụ gụnyere ihe ndị na - arụ ọrụ - glimepiride - 1-4 mg na ngwa inye aka: lactose monohydrate, povidone, sodium carboxymethyl stachi, microcrystalline cellulose, indigo carmine na magnesium stearate.

Mpempe mwepụta

A na-emepụta Amaryl na mbadamba nwere 1-4 mg, nke a na-etinye ya na mbak. Otu mkpọ ọgwụ ahụ nwere ike ị nweta blisters 2, 4, 6 ma ọ bụ 8.

Omume ọgwụ

Mbadamba amaryl nwere mmetụta hypoglycemic.

Pharmacodynamics na pharmacokinetics

Ihe ngbanwe

Onwere ndepụta nke contraindication buru ibu maka iwere Amaril:

Dị 1
imebi oke nke imeju na akụrụ,
ọrịa mamịrị ketoacidosis, precoma na coma,
, ,
ọnụnọ ọrịa dịkarịsịrị ala, dịka ọmụmaatụ, ịkpa ókè galactose, glucose-galactose malabsorption ma ọ bụ ụkọ lactase,
afọ ụmụaka
anabataghị ikike ma ọ bụ uche nke ọgwụ na ihe ndị ọzọ.

Nsonaazụ

N'oge ọgwụgwọ na Amaril, ọtụtụ ihe ịtụnanya dị iche iche nwere ike ịmalite, otu ụzọ ma ọ bụ ọzọ na-emetụta arụmọrụ nke usoro ahụ niile. Ọtụtụ mgbe, a na-egosipụta mmetụta ndị sitere na hypoglycemia, ihe mgbaàmà nke egosipụtara :, agụụ, ọgbụgbọ, vomiting,,,, na ọtụtụ ọrịa ndị ọzọ. Mgbe ụfọdụ enwere nnukwu onyonyo nke ọrịa hypoglycemia yiri ọrịa strok. Mgbe kpochasịrị ya, mgbaàmà ndị achọghị.

Na nmalite ọgwụgwọ mbụ, nsogbu ọhụụ, usoro nri, yana izụ ọbara nwere ike ime. Ọ ga - ekwe omume mmepe, nke nwere ike ịghọ nsogbu. Ya mere, ọ bụrụ na mgbaàmà achọghị ya apụta, ị kwesịrị ịgakwuru dọkịta ozugbo.

Ntụziaka maka Amaryl (Usoro na usoro onunu ogwu)

Emebere mbadamba ihe ndị a maka ihe niile dị na ya, na-enweghị ị cheụ mmiri na ị drinkingụ ọtụtụ mmiri.

Ntụziaka maka ojiji nke Amaril na-emekwa ka a mata na n’oge ọgwụgwọ, mkpebi nke itinye glucose n'ọbara yana ọkwa glycosylated haemoglobin dị mkpa.

Iri mbata ọ bụla, na ịpụ ọzọ, anaghị atụ aro ka iji nwetinye ya ọzọ. Ọnọdụ ndị dị otú ahụ kwesịrị ka ekwenye n'ihu dọkịta na-ahụ maka ịga.

Na mbido ọgwụgwọ, a na-enye ndị ọrịa ọgwụ kwa ụbọchị nke 1 mg. Ọ bụrụ na ọ dị mkpa, a na-eji nwayọ nwayọ nwayọ, na-arụ ọrụ nlebara anya mgbe niile maka ịgwọ glucose ọbara dị ka atụmatụ: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg - 8 mg. Usoro ọgwụgwọ a na-eme kwa ụbọchị na ndị ọrịa nwere ezigbo njikwa bụ 1-2 mg nke ihe na-arụ ọrụ. Kwa ụbọchị nke 6 mg ma ọ bụ karịa na-arụpụta ihe ọ bụ naanị na ọnụ ọgụgụ dị nta nke ndị ọrịa.

Ọtụtụ mgbe, a na-enye ọgwụ otu ụbọchị ị dailyụ ọgwụ, tupu nri ụtụtụ zuru ezu ma ọ bụ nri nri mbụ. Ọ dị mkpa na iri mbadamba mbadamba ịhapụ nri.

A maara na imeziwanye usoro metabolic nwere njikọ na ịba ụba nke insulin, yana n'oge ọgwụgwọ, mkpa maka glimepiride nwere ike iju.Enwere ike ịhapụ hypoglycemia site na mbenata usoro onodu oge ya ma ọ bụ site na ịkwụsị Amaril.

N'oge usoro ọgwụgwọ, mmezi usoro onunu ogwu glimepiride nwere ike iru mgbe:

mbelata ibu
ndụ ya agbanwe
ihe omume ndị ọzọ na - ebute bute ọrịa hypoglycemia ma ọ bụ hyperglycemia.

Dịka iwu, a na-eme ọgwụgwọ Amaril ogologo oge.

Dodoụbiga ya ókè

N'ihe banyere oke ịdoụbiga ọgwụ ókè ma ọ bụ iji ogologo oge iji oke doses glimepiride oké hypoglycemia, nke nwere ike igbu mmadụ, nwere ike ịda.

Ọ bụrụ n ’ịdoụbiga ihe ọdoụdoụ ókè, ị kwesịrị ịgakwuru dọkịta. Enwere ike ịkwụsị hypoglycemia site na ị carbohydụ carbohydrates, dịka ọmụmaatụ, glucose ma ọ bụ obere mpempe nke ọ bụla. Ruo mgbe a kpochapụrụ ọrịa hypoglycemia kpamkpam, onye ọrịa chọrọ nlekọta ahụike nke ọma, ebe ọ bụ na ngosipụta ndị achọghị na-amalite. Usoro ọgwụgwọ ọzọ na-adabere na mgbaàmà ahụ.

Mmekorita

Ojiji nke glimepiride na ọgwụ ụfọdụ nwere ike ime ka mmepe nke hypoglycemia, dịka ọmụmaatụ,Insulin na ndị ọzọ hypoglycemic elekọta mmadụ, Ndị na - egbochi ACE, ọgwụ anabolic steroid na nwoke nwoke homonụ nwokeusoro Coumarin, Cyclophosphamide, Dizopyramide, Fenfluramine, Feniramidol, Fibrates, Fluoxetine, Guanethidine, Ifosfamide, MAO inhibitors, para-aminosalicylic acid, Phenylbutazone, Azapropazone, Oksifenbutazonlami, Salin na ndị ọzọ.

N'ikuku , mgbochi ego , GKS , diazoxides , diuretics , na ndị ọzọ na - enye ihe ọmụmụ, na - egbu mmụọ (iji ọgwụ were ogologo oge), estrogen na progestogens, phenothiazines, phenytoins, rifampicins,homonu ayodiin nwere ayodiin na-eme ka ike gwụ hypoglycemic mmetụta, na ya mere, na-eme ka ịba ụba nke glucose n'ọbara.

Iji wusie ike ma ọ bụ mebie mmetụta hypoglycemic nke glimepiride nwere ike igbochi ndị na-anabata H2-histamine,, na beta-blockers.

Usoro ahia

N’ebe a na-ere ọgwụ, ọgwụ a na-enye ya ọgwụ.

Nnyocha Nyocha

Ọtụtụ nyocha nke ndị ọrịa na ndị ọkachamara na-egosi na n'ịgwọ ọrịa shuga mellitus, nhọrọ kwesịrị ekwesị nke usoro onunu ogwu na usoro ọgwụgwọ dị ezigbo mkpa.

Ọzọkwa, nyocha nke Amaril na-egosi na ọgwụ a adabara ndị ọrịa mamịrị niile. Ọtụtụ mgbe, na mmalite ọgwụgwọ, ndị ọrịa na-enwe mgbanwe dị ukwuu na ihe shuga dị n'ọbara. Agbanyeghị, ndị ọkachamara kwenyesiri ike na n'ọnọdụ ndị dị otú a, ndozi dose dị mkpa na ụzọ mmụba ma nke a abụghị mgbe ọ bụla na-egosi enweghị ike nke ọgwụ.

N’ezie, mmezi ọ bụla metụtara ma ịba ụba ma ibelata usoro ọgwụgwọ ahụ kwesịrị ka eme ya n’okpuru nlekọta nke onye ọkachamara. E guzobere ya na nnabata nke Amaril na-amaghị akwụkwọ nwere ike ibute ọrịa.

Analogs kachasị mma nke amaryl

Emere ọgwụ ọgwụ

Pharmacokinetics nke ọgwụ

Njirimara nke ọgwụ a

Ntuziaka maka iji ọgwụ ahụ

Njere uto na mmeghachi omume ojoo

Efu, nyocha na analogues

Amaril - ntuziaka maka ojiji nke ịgwọ ọrịa shuga, usoro nke ime ihe, contraindications na nyocha

Ihe ngosi maka ojiji

Mmanya na Amaryl

Mkparịta ụka ọgwụ ọjọọ

Nsonaazụ

Dodoụbiga ya ókè

Anaarila Amarila

Amaril ma ọ bụ ndị ọrịa mamịrị - nke ka mma

Ọnụahịa Amaril

Mbadamba amaryl - ntuziaka, nyocha nke onye ọbịa, ọnụahịa

Ntụziaka dị mkpirikpi

Amaryl ma ọ bụ Glucophage

Amaril na Yanumet

Ọrịa mamịrị, Maninil na ọgwụ ndị yiri shuga - nke ka mma ịrịa ọrịa shuga.

Diabeton na Diabeton MV: iche

Enwere m ike iri otu oge?

Na Glucophage

Gliclazide MV

Glidiab MV

Ngwakọta, usoro onunu ogwu, udiri usoro

Ngwongwo na-agwọ ọrịa

Ofzọ nke ngwa

Ntuziaka na mgbochi

Mkparịta ụka ọgwụ ọjọọ

Nsonaazụ

Mpempe mwepụta

Mmekorita

Exbọchị mmebi

Ime ime, lactation

Nkọwa nke ụdị usoro onunu ogwu

Mlọ ọgwụ

Mlọ ọgwụ

Ime na lactation

Ntụziaka pụrụ iche

Emeputa

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

Oge ihe omume

Ihe ngbanwe

Ntụziaka maka Amaryl (Usoro na usoro onunu ogwu)

Usoro ahia

Atụmatụ nchekwa

Exbọchị mmebi

Mmanya na Amaryl

Ime ime, lactation

Ngwakọta na ụdị ntọhapụ

Nkọwa nke ụdị usoro onunu ogwu

Njirimara

Omume ọgwụ

Mlọ ọgwụ

Mlọ ọgwụ

Ihe ngbanwe

Ime na lactation

Nsonaazụ

Mmekorita

Dodoụbiga ya ókè

Usoro onunu ogwu na nhazi

Ntụziaka pụrụ iche

Emeputa

Ntụziaka dị mkpirikpi

Ọrịa shuga na oke nrụgide ga-abụ ihe mgbe ochie

Oge ihe omume

Mmanya ndakọrịta

Anaarila Amarila

Amaryl ma ọ bụ ndị ọrịa mamịrị

Amaryl ma ọ bụ Glucophage

Amaril na Yanumet

Emere ọgwụ ọgwụ

Pharmacokinetics nke ọgwụ

Njirimara nke ọgwụ a

Ntuziaka maka iji ọgwụ ahụ

Njere uto na mmeghachi omume ojoo

Efu, nyocha na analogues

Mpempe mwepụta