Glimecomb - ọgwụ abuo maka oria abuo

Otu mbadamba ihe nwere:

bekee na-arụ ọrụ: metformin hydrochloride n'ihe nke 100% ihe-500 mg, glycazide na usoro nke 100%-40 mg,

ndị na-emebu: sorbitol, povidone, ssumum croscarmellose, magnesium stearate.

Mbadamba ụrọ sitere na ọcha na agba ọcha nwere ncha ma ọ bụ odo na-acha odo odo, cylindrical ewepụghị, na bevel na ihe ize ndụ. Anabataghị ọnụnọ nke marbling

PHARMACOTHERAPEUTIC GROUP:

mgbakwunye hypoglycemic na-elekọta mmadụ maka ọnụ iji (biguanide + sulfonylurea group planning)

ATX CODE: A10BD02

PHARMACOLOGICAL PRESALES Pharmacodynamics.

Glimecomb® bụ ngwongwo abụọ nke ọgwụ hypoglycemic nke otu ọgwụ dị iche iche: glyclazide na metformin. Ọ nwere nsị ọ na-akpata ọria.

Gliclazide na - eme ka mmiri ọgwụ insulin na - egbochi insulin, na - eme ka anụ ahụ ndị dị na insulin na - emekwuwanye ihe. Na-akpali ọrụ nke enzymes intracellular - muscle glycogen synthetase. Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ, na --belata oge dị iche site na oge iri nri na mmalite insulin insulin, ma belata hyperglycemia postprandial. Na mgbakwunye na emetụta metabolism metabolism, ọ na - emetụta microcirculation, belata adhesion platelet na nchịkọta, na - egbu oge mmepe nke parietal thrombosis, na - egbochi vaskụla permeability ma na - egbochi mmepe microthrombosis na atherosclerosis, na - eweghachite usoro nke physiological parietal fibrinolysis, na ịgbagha vrenterenine. Na-eme ka mmepe nke ọrịa mamịrị na-arịa ọrịa retinopathy na-abụghị nke na-aba ụba, na-arịa nephropathy na-arịa ọrịa ogologo oge, a na-ahụta mbelata dị ukwuu na proteinuria. Ọ dịghị ebute mmụba n’arụ ahụ, ebe ọ nwere mmetụta kachasị na mbido insulin insulin ma ghara ibute hyperinsulinemia, ọ na - enyere aka belata oke ahụ n'ahụ ndị ọrịa buru ibu, na - agbaso nri kwesịrị ekwesị.

Metformin bụ otu nke biguanides. Ọ na - ebelata oke glucose n'ọbara site na igbochi gluconeogenesis na imeju, na - ebelata nnabata glucose na eriri afọ ma na - abawanye uru ya na anụ ahụ. Na-ebelata itinye uche na ọbara ọbara nke triglycerides, cholesterol na obere lipoproteins dị ala (ekpebisiri ike na afọ efu) na anaghị agbanwe ntinye uche nke lipoproteins nke ihe ndị ọzọ. Ọ na - enyere aka ịgbatị ma ọ bụ belata ahụ. Na enweghị insulin n'ime ọbara, a naghị egosipụta mmetụta ọgwụgwọ. Ọkpụkpụ hypoglycemic anaghị akpata. Ọ na - eme ka akwara fibrinolytic dị n'ọbara n'ihi mkpesa nke onye na - egbochi nnabata profibrinolysin (plasminogen) ụdị anụ ahụ.

Gliclazide. Idopu ihe n’ulo di elu. Mgbe nchịkwa ọnụ nke 40 mg, a na-enweta ntinye uche kachasị na plasma ọbara mgbe awa 2-3 gachara 2-3 μg / ml. Nkwukọrịta na protein protein bụ 85-97%. Oge iwepu ọkara ndụ bụ awa asatọ 8-20. A na - abụkarị ya n'ụdị metabolites site na akụrụ ya - 70%, site na eriri afọ - 12%. N'ime ndị agadi, a naghị ahụ mgbanwe mgbanwe dị ukwuu na ọgwụ ọgwụ. Metformin. Ibepu - 48-52%. Gbasoro ngwa ngwa na eriri afọ. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%, ịbanye na nri na-ebelata ịta kachasị site na 40% ma belata ọganiizu ya na nkeji 35. A na-enweta ntụpọ Plasma mgbe awa 1.81-2.69 na-agafeghị 1 μg / ml. Ikwurita okwu na protein ndi plasma abaghi ​​uru, o nwere ike idi otutu n’ime obara obara uhie. Ọkara ọkara bụ awa 6.2. Ọ bụ akụrụ na-emegharị ya, ọkachasị adịghị agbanwe agbanwe (mmiri nhicha na ngwakọta nke mmiri) yana site na eriri afọ (ihe ruru 30%).

EGO NA-EGO

• mdị ọrịa shuga abụọ nke mellitus na arụmọrụ nke usoro ọgwụgwọ nri, mmega ahụ na usoro ọgwụgwọ gara aga na metformin ma ọ bụ gliclazide.

• Jiri ọgwụ abụọ (metformin na gliclazide) mee ọgwụ ọgwụgwọ gara aga n’ebe ndị ọrịa nwere ọria mamịrị nke 2 nọ nke nwere glucose ọbara.

NSOGBU NIILE

• hypersensitivity maka metformin, glyclazide ma ọ bụ ihe ndị ọzọ na - eme ka sulfonylurea, yana ihe inyeaka,

• ụdị shuga 1

• ọrịa mamịrị ketoacidosis, precca shuga, ọrịa shuga,

• enweghi ezigbo nsogbu gbasara akụrụ,

• ọnọdụ ọjọọ nke nwere ike ibute mgbanwe ọrụ akụrụ: akpịrị ịkpọ nkụ, ọrịa siri ike, ujo,

• ọrịa siri ike ma ọ bụ nke na-adịghị ala ala nke gụnyere hypoxia anụ ahụ: obi ma ọ bụ akụkụ okuku ume, ndaba na myocardial infarction, ujo,

• afọ ime, oge inye ara,

• nhazi nke miconazole,

• ọrịa na-efe efe, nnukwu ihe ịwa ahụ, mmerụ ahụ, oke ọkụ na ọnọdụ ndị ọzọ chọrọ ọgwụgwọ insulin.

• egbu egbu egbu, ị intoụbiga mmanya ókè,

• lactic acidosis (gụnyere akụkọ ihe mere eme)

• jiri maka opekata mpe, awa iri asatọ na asatọ tupu ma ọ bụ n'ime elekere 48 ka ị mụsịrị nyocha redio ma ọ bụ x-ray na ntinye nke ayodiin nwere ihe dị iche,

• rubere nri nwere kalori (obere kalori 1000 / ụbọchị).

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.

Jiri nlezianya

Ọrịa Feverish syndrome, adrenal insufficiency, hypofunction of the face pituitary gland, ọrịa thyroid na arụ ọrụ.

PLKP DR D REBRER P AKP ANDR AND NA EGO N’RELỌ NIILE

N'ime afọ ime, iji ọgwụ Glimecomb® mee ọgwụ mgbochi. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n’ihe gbasara afọ ime n’oge ịlụ Glimecomb®, ọgwụ ahụ kwesịrị ịkwụsị ya, ekwesịrị ịdekwa ọgwụ insulin.

Glimecomb® na enye ara ara, ebe ogwu ahu nwere ike banye n’ime mmiri ara. N'okwu a, ị ga-agbanwere ọgwụ insulin ma ọ bụ kwụsị inye ara.

OSM ANDAKA NA ỌM .AKA

A na-eji ọgwụ ọnụ, n'oge nri ma ọ bụ ozugbo nri. Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ogologo glucose ọbara.

Ọ na - abụkarị ọgwụ mbụ bu mbadamba 1-3 kwa ụbọchị yana iji nwayọ nwayọ were kọọ ruo mgbe egosiri ịkwụghachi ọrịa ahụ.

A na-a theụ ọgwụ ahụ ugboro abụọ n'ụbọchị (n'ụtụtụ na mgbede). Oke kachasị kwa ụbọchị bụ mbadamba ise.

NWAANYI EGO

Site n'akụkụ nke metabolism: n'ihe banyere mmebi nke usoro dosing regimen na nri na-ezighi ezi, hypoglycemia (isi ọwụwa, mmetụta nke ike ọgwụgwụ, agụụ, ịba ụba ịba ụba, adịghị ike nkọ, palpitations, ọgbụgba, njikwa nkwonkwo nke mmegharị, nsogbu akwara ozi nwa oge, ya na ọganihu nke hypoglycemia, onye ọrịa ahụ nwere ike ịkwụsị njide onwe onye na nsụhọ), n'ọnọdụ ụfọdụ - lactic acidosis (adịghị ike, myalgia, nsogbu nke akụkụ iku ume, ụra, ụkwara ume ọkụ, hypothermia, ọbara mgbali elu, reflex b) radiarrhythmia).

Site na usoro digestive: dyspepsia (ọgbụgbọ, afọ ọsịsa, mmetụta nke oke na epigastrium, "ụtọ" n'ọnụ), na-ebelata agụụ - ogo ahụ na-ebelata ọgwụ mgbe ị na-eri nri, adịkarịghị - mmebi imeju (ịba ọcha n'anya, cholestatic jaundice - chọrọ ọgwụ ịhapụ, mmụba nke “nsị” transaminases, alkaline phosphatase).

Site na akụkụ ahụ haemopoietic: adịkarịghị - mgbochi nke ụmị ọkpụkpụ (anaemia, thrombocytopenia, leukopenia).

Mmeghachi omume nfụkasị ahụ: itching, urticaria, flop na maculopapular.

Ọ bụrụ na nsonaazụ ndị ọzọ, a ga-belata dose ahụ ma ọ bụ kwụsị ọgwụ ahụ ruo nwa oge.

Ndị ọzọ: enweghi ike ịhụ ụzọ.

Nsonaazụ ndị ọzọ a na-ahụkarị na njikọta sulfonylurea: erythropenia, agranulocytosis, hemolytic anaemia, pancytopenia, vasculitis nfụkasị, ọrịa imeju na-egbu ndụ.

OGBONA

Dodoụbiga mmanya ókè ma ọ bụ ọnụnọ nke ihe ndị dị ize ndụ nwere ike ịkpasu mmepe nke lactic acidosis, ebe ọ bụ na metformin bụ akụkụ nke ọgwụ ahụ. Ọ bụrụ na mgbaama nke lactic acidosis apụta, kwụsị ị theụ ọgwụ. Lactic acidosis bụ ọnọdụ chọrọ nlekọta ahụike mberede, ọgwụgwọ nke lactic acidosis kwesịrị ịrụ n'ụlọ ọgwụ. Ọgwụ kachasị dị irè bụ ịba ọcha n'anya. Do overụbiga mmanya ókè nwekwara ike iduga mmepe nke hypoglycemia n'ihi ọnụnọ nke gliclazide na nkwadebe. Site na iji hypoglycemia dị nwayọ ma ọ bụ na-agafeghị oke, a na-eji ọnụ gwuo glucose (dextrose) ma ọ bụ mmiri shuga. N'ọnọdụ ọgbụgba hypeglycemia (enweghị nke mmụọ), a na-edozi 40% dextrose (glucose) ma ọ bụ glucagon intravenously, intramuscularly, subcutaneously. Mgbe ọ nwetasịrị onwe ya, a ga-enyerịrị onye ọrịa ahụ nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

NWAANYI NA EGO

Ndị na-egbochi mmetụta hypoglycemic nke ọgwụ ahụ bụ angiotensin na-agbanwe enzyme inhibitors (captopril, enalapril), ndị na-anabata H2-histamine blockers (cimetidine), ọgwụ antifungal (miconazole, fluconazole), ọgwụ mgbochi anti-inflammatory ọgwụ (NSAIDs), phenyl ), mgbochi ụkwara nta (ethionamide), salicylates, coumarin anticoagulants, steroid anabolic, beta-blockers, monoamine oxidase inhibitors, sulfonamides Omume n'uko ọcha, cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, ọzọ hypoglycemic ọgwụ (acarbose, biguanides, insulin, wdg), allopurinol oxytetracycline.

Barbiturates, glucocorticosteroids, agonist adrenergic (epinephrine, clonidine), ọgwụ antiepileptik (phenytoin), ndị na-egbochi calcium ọsịsa, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, trifenazole azeneazide, azinazole, azinazole, azinazole , morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, homonụ thyroid, nnu nke lithium, oke nicotinic acid, chlorpromazine, ọgwụ mgbochi ọgwụ na estrogens.

Na-abawanye n'ihe ize ndụ nke ịmalite extraventystoles ventricular na na ndabere nke glycosides cardiac. Ọgwụ ndị na-egbochi hematopoiesis ụmị ọkpụkpụ na-abawanye ihe ize ndụ nke myelosuppression.

Ethanol na - eme ka o nwee ohere nke tobe acid acidis.

Metformin na-ebelata oke itinye uche na ọbara (C max) na T 1 / 4furosemide site na 31 na 42.3%, n'otu n'otu. Furosemide mụbara C max metformin na 22%.

Nifedipine na-abawanye nnabata, C max, na -ebelata mmịpụta nke metformin.

Ọgwụ cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ebugharị tubular ma, site na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye C max metformin na 60%.

AKWECKWỌ NDEC NA-EGO

Ọgwụ Glimecomb® ka a na-eme naanị yana ijikọtara kalori, obere carb. Ọ dị mkpa ịdị na-enyocha ọkwa glucose mgbe niile n'ọbara na afọ na-enweghị nri na mgbe erichara nri, ọkachasị na ụbọchị mbụ ọgwụgwọ ọgwụ.

Enwere ike inye glimecomb® naanị ndị ọrịa na-anata nri mgbe niile, nke na-abụkarị nri ụtụtụ, na-ahụ na ịnweta carbohydrates zuru oke.

Mgbe ị na-edepụta ọgwụ ahụ, ekwesịrị iburu n'uche na n'ihi nnweta nke ikike dị iche iche nke sulfonylurea, hypoglycemia nwere ike ịmalite, na n'ọnọdụ ụfọdụ n'ụdị siri ike ma dịte aka, chọrọ ụlọ ọgwụ na nchịkwa glucose ruo ọtụtụ ụbọchị. Hypoglycemia na-etolitekarị nri nwere kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị alcoholụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge.

Iji zere mmepe nke hypoglycemia, a chọrọ nlezianya na nhọrọ nke usoro onunu ogwu, yana inye onye ọrịa ozi zuru ezu gbasara ọgwụgwọ a tụrụ aro.

Site na iji oke oke nke anụ ahụ na nke mmetụta uche, mgbe ị na-agbanwe nri, ịkwesịrị ịhazigharị Glimecomb®.

Karịsịa enwee mmetụta banyere ọgwụ hypoglycemic ọgwụ: ndị agadi, ndị ọrịa na-anaghị enweta ezigbo nri, yana steeti na-esighi ike, ndị ọrịa na-ata ahụhụ site na enweghi nri. Beta-blockers, clonidine, reserpine, guanethidine nwere ike kpuchie ngosipụta nke hypoglycemia.

E kwesịrị ịdọ ndị ọrịa ọdụ gbasara ịba ụba hypoglycemia n'ọnọdụ ethanol, NSAIDs, na agụụ.

Nnukwu ihe ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile nwere ike ịchọ nkwụsị nke ọgwụ hypoglycemic nke ọnụ na ịhọpụta ọgwụgwọ insulin. N'oge ọgwụgwọ, ọ dị mkpa ileba anya maka ọrụ akụrụngwa; ekwesịrị ime mkpebi nke plasma lactate ọbụlagodi ugboro abụọ n’afọ, yana n’ile anya myalgia. Mmepe nke lactic acidosis chọrọ ịkwụsị ọgwụgwọ.

Oge awa 48 tupu ịwa ahụ ma ọ bụ nchịkwa nchịkwa nke ihe na-akpata rediopaque nke ayodiin, Glimecomb® kwesịrị ịkwụsị, a na-atụ aro ka ịmaliteghachi mgbe awa 48 gachara.

Megide usoro ọgwụgwọ na Glimecomb®, onye ọrịa ahụ ga-ahapụ ị ofụ mmanya na / ma ọ bụ ọgwụ na nri.

N'oge ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mmụba nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Ihe ngosi maka oge atọrọ

Ngwurugwu Sulfonylurea (PSM) bụ ọgwụ ndị ọgwụ kachasị echere maka ndị ọrịa shuga mgbe metformin gasịrị. Nmekorita nke PSM na metformin choro maka ndi oria ahu bu ndi nri nri eji aru ala, egwuregwu, na metformin adighi enye mbelata nkpuru-obi choro. Ihe ndị a na-arụ ọrụ na njikọta pathogenesis bụ isi nke ụdị ọrịa shuga 2 mepụtara: nnwale insulin dị elu na ụkọ insulin, yabụ ha na-enye nsonaazụ kacha mma na njikọta. Glyclazide, akụkụ nke ọgwụ Glimecomb, bụ PSM nke ọgbọ abụọ ma a na-ewere ya dị ka otu n'ime ihe ndị kachasị nchebe na ndị otu ya.

Enwere ike ịre mbadamba glimecomb:

1. Mgbe usoro ọgwụgwọ gara aga kwụsịrị inye ezigbo ụgwọ maka ọrịa shuga.
2. Ozugbo achọpụtara ọrịa shuga, ọ bụrụ na ọkwa nke glycemia dị elu.
3. Ọ bụrụ na ndị ọrịa shuga anaghị anabata metformin na nnukwu ọgwụ.
4. Iji belata ọnụọgụ mbadamba na ndị ọrịa na-ewere gliclazide na metformin.
5. Ndị ọrịa mamịrị nke glibenclamide (Maninil na analogues) ma ọ bụ njikọta ya na metformin (Glibomet na ndị ọzọ) na-akpata nnukwu ịba ụba ma ọ bụ nke a na-enweghị ike ịkọwa na hypoglycemia dị ukwuu.
6. Ọrịa nwere nsogbu gbasara akụrụngwa maka onye amachibidoro glibenclamide.
7. Na-arịa ọrịa shuga gbagwojuru anya site n'ọrịa obi. Egosighi Gliclazide nwere mmetụta na myocardium.

Dabere na ọmụmụ, ugbua maka ọnwa nke ọgwụgwọ na Glimecomb, glucose na-ebu ọnụ na-ebelata site na nkezi 1.8 mmol / L.Site n’iji ọgwụ ọjọọ na-aga n’ihu, ihe ọ na-eme na-akawanye njọ, mgbe ọnwa atọ belata ya adịlarị 2.9. Ọgwụ ọnwa atọ ahaziri glucose na ọkara nke ndị ọrịa nwere ọrịa mellitus decompensens nke ukwuu, ebe dose ahụ akarịghị mbadamba 4 kwa ụbọchị. Edeghị oke ibu na oke hypoglycemia, chọrọ ọgwụgwọ n'ụlọ ọgwụ, ekwenyeghị na ọgwụ a.

Ọgwụ Farmacology Glimecomb

A na-ewere njikọta PSM na metformin dịka nke ọdịnala. N'agbanyeghị ntopute nke ndị nnọchianya hypoglycemic ọhụrụ, ndị otu shuga na mba ụwa na Ministri Ahụike nke Russian Federation na-aga n'ihu ịkwado njikọ a dịka nke kacha bụrụ nke kacha mma. Glimecomb dị mfe iji ma dịkwa ọnụ ala. Ihe mejupụtara ya bụ ihe arụ ọrụ ma dịkwa nchebe.

Glyclazide nke nwere ụdị ọrịa shuga 2 na-akpali mmepụta nke insulin onwe ya, ma malite ịrụ ọrụ na akụkụ mbụ nke nzuzo ya, mgbe shuga abanyela n'ọbara. Ihe omume a ga - enyere gị aka belata glycemia ngwa ngwa mgbe ị risịrị nri, na - ebugharị glucose na anụ ahụ. Glyclazide na-egbochi mmepe nke angiopathy: na-egbochi thrombosis, na-eme ka microcirculation na steeti nke mgbidi arịa ọbara. E gosipụtala mmetụta dị mma nke gliclazide n'ụzọ nke retinopathy na nephropathy. Mbadamba ụrọ nke glimecomb ihe a anaghị ebute oke insulin n'ime ọbara, yabụ ha anaghị ebute oke ibu. Ntuziaka ahụ gosikwara ike nke gliclazide iji meziwanye insulin, mana na nke a, ọ nọghị na metformin, onye ndu a ma ama na ọgụ megide mgbochi insulin.

Metformin bụ naanị ọgwụ akwadoro maka ụdị ndị ọrịa shuga niile dị afọ atọ na enweghị ya iche. Ọ na - akpali ntụgharị nke glucose site na akwara ọbara na sel, na - egbochi imeju glucose site na imeju, na - egbu oge ịmịnye ya na eriri afọ. Ọgwụ ahụ na-alụ ọgụ ọria metabolism n’agha, nke e ji mara ụdị 2 nke ọrịa ahụ. N'ihi ọtụtụ nyocha dị mma nke ndị ọrịa mamịrị, a na-eji metformin eme ihe maka ịdị felata. Ọ naghị ebute hypoglycemia, mgbe ejiri ya na ntuziaka ndị ahụ dị nchebe kpamkpam. Ọdịmma nke ihe mgbakwunye a nke Glimecomb bụ nnukwu ọnụọgụ nke mmetụta na-adịghị mma na ngwangwa nri.

Pharmacokinetics nke mmiri ọgwụ:

2 awa mgbe etinyere na ukpọk afo

Oge awa 2.5 ọ bụrụ na ị foodụrụ ọgwụ ahụ n'otu oge.

Ọgwụ Glimecomb nwere otu usoro onunu ogwu - 40 + 500, na mbadamba 40 mg nke glyclazide, 500 mg nke metformin. Iji nweta ọkara, a ga-ekewa mbadamba nkume ahụ, enwere ihe ize ndụ na ya.

Ọ bụrụ na ndị nwere ọrịa shuga ewerebeghị metformin na mbụ, a na-ewere mbadamba 1 dị ka akara amalite. Izu abụọ na - esote, ọ bụ ihe na - achọghị ka ịbawanye ya, yabụ ị nwere ike belata ihe egwu nke ahụ erughị ala na sistem nri. A ga-edenye ndị ọrịa maara metformin ma nwee ike ịnabata ya nke ọma ruo mbadamba 3 Glimecomb ozugbo. Dọkịta a chọrọ ka dọkịta kpebisiri ike, na-eburu n'uche ọ̀tụ̀tụ̀ glycemia onye ọrịa na ọgwụ ndị ọzọ ọ na-a .ụ.

Ọ bụrụ na usoro ịmalite adịghị enye nsonaazụ achọrọ, a na-amụba nwayọọ nwayọọ. Iji gbochie hypoglycemia, oge dị n’etiti mgbanwe ịgba kwesịrị ịdịkarị otu izu. Nke kacha karịa bụ mbadamba ise. Ọ bụrụ na n'ọtụtụ a, Glimecomb adịghị enye nkwụghachi ụgwọ maka ọrịa shuga mellitus, a na-enye onye ọrịa ọgwụ ọgwụ na-ebelata shuga.

Ọ bụrụ na onye ọrịa ahụ nwere ọgwụ insulin na-eguzogide ọgwụ dị elu, a pụrụ ị Gụ Glimecomb n'ọrịa shuga na metformin. A na-agbakọ ọnụ ọgụgụ mbadamba ihe dị na nke a ka ngụkọta nke metformin anaghị agafe 3000 mg.

Iwu maka ị theụ ọgwụ Glimecomb

Iji meziwanye nnabata nke metformin ma gbochie nnukwu shuga na-egbu egbu, mbadamba mmiri Glimecomb na-abụ mmanya n'otu oge na nri ma ọ bụ ozugbo ọ gasịrị. Nri kwesiri idi ezigbo ike ma aghaghi inwe carbohydrates, kariri ike gwuo nri. Na-ekpe ikpe site na nyocha, ihe ruru 15% nke ndị ọrịa mamịrị kwenyere na ị Gụ ọgwụ Glimecomb na ọgwụ ndị ọzọ na-ebelata shuga na-ewepụ mkpa ha nwere ịgbaso nri. N’ihi nke a, ha na-a increasedụkwu ọgwụ ị na-a ,ụ, nke na-abawanye ihe ọ na-akpata na ọnụ ahịa ọgwụgwọ, na-eme mkpesa maka shuga na-egbu egbu, ma na-eche nsogbu ọrịa shuga mbụ.

Ugbu a, ọ nweghị otu ọgwụ mbadamba ọgwụ maka ọrịa shuga ga-anọchi nri. Site na ụdị ọrịa nke 2, a na-egosipụta ihe oriri na-edozi ahụ na-enweghị carbohydrates ngwa ngwa, yana mmachi nke carbohydrates dị nwayọ, na mgbe mgbe enwere ọdịnaya nwere obere calorie - nri maka ụdị shuga 2. Usoro ọgwụgwọ dị mkpa ịgụnye nhazi nke ịdị arọ na ịba ụba nke ọrụ.

Iji hụ na arụmọrụ nke Glimecomb n'ehihie, a na-ekezi usoro onyonye ọgwụ eji eme ọgwụ abụọ - n'ụtụtụ na anyasị. Dabere na nyocha, a na-ahụ nsonaazụ ọgwụgwọ kachasị mma na ndị ọrịa na-a theụ ọgwụ ahụ ugboro atọ (mgbe nri ọ bụla), n'agbanyeghị eziokwu ahụ maka iji ya adịghị enye maka ụdị nhọrọ a.

Dọkịta nke Sciences Medical, Isi nke Institute of Diabetology - Tatyana Yakovleva

M na-amụ ọrịa shuga kemgbe ọtụtụ afọ. Ọ na-atụ ụjọ mgbe ọtụtụ mmadụ nwụrụ, nweekwa nkwarụ karịa n'ihi ọrịa shuga.

Emere m ngwa ngwa izisa ozi ọma - Endocrinological Research Center nke Russian Academy of Medical Sciences jisiri ike mepụta ọgwụ na-agwọ ọrịa shuga kpamkpam. N'oge a, ịdị irè nke ọgwụ a na-eru nso 98%.

Ozi ọma ọzọ: Ministri Ahụike echekwaala maka mmemme pụrụ iche nke na-akwụ ụgwọ ọgwụ dị elu. Na Russia, ndị ọrịa mamịrị ruo Mee Mee 18 (isonye) nwere ike inweta ya - Naanị 147 rubles!

Nsonaazụ

Enwere ike ịkụda ọtụtụ mmetụta ndị ọzọ na-emetụta ma ọ bụrụ na ịgbaso iwu maka ịnara na ịba ụba dose ahụ site na ntuziaka. Celkagbu Glimecomb n'ihi anagideghị ya anaghị adịkarị mkpa.

Ihe ngbanwe

Mgbe ị nweghị ike ị drinkụ Glimecomb:

• ụdị shuga 1
• hypoglycemia. Ọgwụ agaghị enwe ike ị medicineụbiga mmanya ruo mgbe shuga ọbara bilitere na nkịtị,
• nnukwu ọrịa shuga, ọrịa na mmerụ ahụ chọrọ insulin insulin. Ihe banyere lactic acidosis n'oge gara aga,
• ime, inye ụmụ ara,
• X-ray ya na iodine nwere ihe ndi ozo di iche
• anabataghị ọgwụ nke ọgwụ ọ bụla.
• gbasara akụrụ, ọrịa imeju, hypoxia, na ọrịa ndị ọ nwere ike ibute ọrịa ndị a.
• ahoụrụma, ị highụbiga mmanya ókè.

N'ime ndị ọrịa nwere ọrịa homonụ, ndị agadi ọrịa mamịrị ya na mgbali mgbali ogologo oge, ihe ọghọm nke nsonaazụ na-abawanye, yabụ mgbe ị na-ewere Glimecomb, ha kwesịrị ịkpachara anya karịike gbasara ahụike ha.

Ndakọrịta na ọgwụ ndị ọzọ

Enwere ike iwusi mmetụta nke glimecomb ike ma ọ bụ mee ka ike gwụ ya mgbe ị na-eji ọgwụ ndị ọzọ. Ndepụta nke mmekọrịta ọgwụ ọgwụ buru oke ibu, mana ọtụtụ mgbe mgbanwe dị irè adịghị oke mkpa ma enwere ike idozi ya ngwa ngwa site na ịgbanwe usoro ịsụ ọgwụ.

Ihe analogues iji dochie

Glimecomb enweghị aha analogues zuru oke na Russian Federation. Ọ bụrụ na ọgwụ adịghị na ụlọ ahịa ọgwụ, ọgwụ abụọ nwere otu ihe arụ ọrụ nwere ike dochie ya:

1. Metformin dị na Glucofage mbụ mepụtara na France, German Siofor, Metformin Russian, Merifatin, Gliformin. Ha niile nwere usoro onunu ogwu nke 500 mg. Maka ndị ọrịa mamịrị nwere ezigbo ndidi nke metformin, ụdị ọgwụ a gbanwere, bụ nke na -echekwa nnabata otu ihe ahụ n'ime ọbara ma belata oke ihe ọghọm ya. Ndị a bụ ọgwụ Metformin Long Canon, Metformin MV, Formin Long na ndị ọzọ.
2. Gliclazide bụkwa hypoglycemic a ma ama. Nri ahụ bụ akụkụ nke Russia Glidiab na Diabefarm. Gliclazide gbanwere bụ ugbu a dịka ụdị ahọrọ. Ojiji ya nwere ike belata ugboro ole na ogo nke hypoglycemia. Gliclazide gbanwetụrụ dị na njikere Diabefarm MV, Diabeton MV, Gliclazide MV, Diabetalong, wdg. Mgbe ị na-azụ, ịkwesịrị ị toa ntị na usoro onunu ogwu, ị nwere ike ịkewa mbadamba ahụ na ọkara.

Enwere otutu analogues nke Glimecomb n'ahịa Russia. Ọtụtụ n'ime ha bụ ngwakọta nke metformin yana glibenclamide. Ọgwụ ndị a enweghị nchebe karịa glimecomb, n'ihi na ha na-ebute hypoglycemia mgbe niile. Ezigbo nnọchi maka Glimecomb bụ Amaryl (metformin + glimepiride). Ugbu a, ọ bụ ọgwụ abụọ kachasị arụ ọrụ nwere PSM.

Ọnụahịa nke otu mkpọ mbadamba 60 nke Glimecomb sitere na 459 ruo 543 rubles. Gliclazide na metformin sitere na otu onye nrụpụta ga-efu 187 rubles. maka otu uzo (mbadamba 60 nke Glidiab 80 mg na-efu 130 rubles, mbadamba 60. Gliformin 500 mg - 122 rubles). Ọnụahịa nke ngwakọta nke nkwadebe mbụ nke gliclazide na metformin (Glucofage + Diabeton) bụ ihe dịka 750 rubles, ha abụọ bụ ndị na-agbanwe agbanwe.

ISI AKA

Mbadamba 40 mg + 500 mg. Maka 30, 60 ma ọ bụ mbadamba 120 n'ime karama maka ọgwụ ndị eji rọba. Na mbadamba 10 ma ọ bụ 20 na nchịkọta blister. Otu karama ọ bụla ma ọ bụ ngwugwu 6 dị mbadamba 10, ma ọ bụ ngwugwu 5 dị mbadamba 20 n'otu n'otu yana ntuziaka maka iji ya na mkpọ kaadiboodu.

Ozi izugbe

Glimecomb bụ ọgwụgwọ agwakọta maka ụdị ọrịa shuga 2. Ihe mejuputara uzo abuo ya bu metformin na gliclazide. Ihe mbu metutara biguanides, nke abuo bu ihe ochicho sitere na sulfonylurea.

Ọdịiche ya na njikọta nke ihe abụọ kachasị ewu ewu na arụmọrụ. Uru kachasị karịa ọgwụ ndị ọzọ jikọtara ọnụ bụ ntakịrị ihe ize ndụ nke hypoglycemia. Ọ bụ ụlọ ọrụ ọgwụ Russia bụ Akrikhin mepụtara ya.

Ihe ngosi maka ojiji

Emere ọgwụ a maka ndị ọrịa nwere ọrịa shuga 2. Nke mbụ, ndị dọkịta na-atụ aro ọgwụgwọ ọgwụ, yana usoro mmega ahụ kwa ụbọchị. Ọ bụrụ na, mgbe oge ụfọdụ gasịrị, usoro ndị a ewetaghị mmetụta a tụrụ anya ya, a na-agbakwunye ọgwụgwọ ahụ na ọgwụ. Iji bido, a na-enye onye ọrịa ọgwụ ọgwụ otu ihe dabere na metformin. Ọ bụrụ na ọgwụgwọ ahụ adịghị apụta, a na-egosipụta ọgwụgwọ ijikọ.

Mpempe mwepụta

“Glimecomb” bụ mbadamba nkume na-acha ọcha nke ọdịdị cylindrical, larịị. Ejiri okwute maburu. Onwere ihe di egwu banyere diametikal. Mbadamba ụrọ na-etinye na igbe nke 30 ma ọ bụ 60 iberibe.

Ọnụ ego ruru ngwongwo 30 nke “Glimecomba” n'ụlọ ahịa ọgwụ Russia sitere na 276 rubles.

Echere na ọnụ ahịa nke ịkwakọ 60 pcs - site na 524 rubles.

Mbadamba ụrọ nke ọ bụla nwere 500 mg nke metformin na 40 g nke gliclazide. Ndị a bụ ihe abụọ bụ isi ji arụ ọrụ. Ọ bụ akụkụ ndị a na-ekpebi arụmọrụ ya dị elu, yana “ịdị nro” nke ihe a na-eme.

Innovation na ọrịa shuga - na-a everyụ kwa ụbọchị.

N'etiti obere mpaghara: sorbitol, povidone, magnesium stearate, ssumum croscarmellose.

N'ihi ụkọ lactose, a na-ahapụ ọgwụ ka ọ jiri ya mee ihe n'etiti ndị na-adịghị anabata ya.

Ntụziaka maka ojiji

Mkpa mbadamba nke glimecomb ka a na-eji ọnụ mee ihe n’oge nri ma ọ bụ ozugbo nri. Ọ dabere na nha ọnụọgụ yana ọnọdụ nke eriri afọ nke onye ọrịa. N'oge ọgwụgwọ, ọ dị mkpa iji nlezianya debe iwu nke nri obere carb. Dịka iwu ndị a, n'ọnọdụ ịgaghị etinye nri ụtụtụ.

Physicaldị anụ ahụ nke onye ọrịa, yana ọnọdụ mmetụta uche ya, nwere nnukwu mmetụta na usoro onunu ogwu. Agụụ, ọbụlagodi ma ọ bụrụ na obere oge, na ọkachasị ị consumptionụ mmanya, anaghị anabata.

Ekwesịrị ịchekwa nkwakọ ngwaahịa a n'ọchịchịrị n'oge okpomọkụ ruo 25 Celsius. Tupu ịzụta, ọ ka mma ị attentiona ntị na ụbọchị nrụpụta na ụbọchị mmebi. Ọgwụ nwere oge ngafe nke dị nso na njedebe ka mma ịghara ịzụta.

Njirimara ngwa

N'ihi nnukwu ihe ize ndụ nke ịmalite ọrịa lactic acidosis, a naghị atụ aro Glimecomb maka ndị agadi karịa afọ 60, yana maka ndị ọrịa na-arụ ọrụ anụ ahụ dị arọ.

Ime ime bụ ihe zuru oke iji ya eme. Yabụ, n'oge ebu nwa ahụ, yana oge nkwadebe maka ịtụrụ ime, a ga-eji ọgwụ ndị ọzọ dochie ya.

Ụ ara ara emegideghị Glimecomb. N'okwu a, nne nke na-enye nwa ara nwere nhọrọ: ma ọ bụ gụchaa nwa arahụ ma gbanwee gaa na nri anụ, ma ọ bụ dochie ọgwụ n'onwe ya.

Iji nlezianya mee ihe maka ndị ọrịa nwere ọrịa nke usoro endocrine.

Anyị na-enye ndị na-agụ saịtị anyị ego nlele

A na-anabata ọgwụgwọ glimecomb maka ndị ọrịa mamịrị na-agbaso ihe niile achọrọ maka nri obere carb. Nri kwesiri idi nri. Ọdịiche dị ukwuu n'etiti nri nwere ike ịkpalite ọdịda glucose ọbara. Ọzọkwa, hypoglycemia na mberede nwere ike ime ka ị intụ mmanya na-aba n'anya obere obere, yana ọgwụ mgbochi mkpali na-abụghị steroidal.

Mmekọrịta na ọgwụ ndị ọzọ

Enwere ike iwusi ike ọgwụgwọ Glimecomb site na ọgwụ ndị ọzọ. N'ọtụtụ oge, nsonaazụ a adịghị oke mkpa ma wepụ ya site na obere ndozi ọgwụ.

Ọgwụ na-ebelata ike hypoglycemic nke Glimecomb:

• ọgwụ mgbochi nke steroid,
• ọgwụ ọ bụla nke homonụ, tinyere mgbochi afọ,
• diuretics
• ọgwụ nwere nicotinic acid,
• antidepressants.

Ọgwụ ndị na-eme ka ikike glycemic dị ike:

• ọgwụ mgbochi
• Vitamin B6
• ọgwụ mgbochi-anaghị alụ ọgụ,
• ọgwụ ndị ọzọ na-ebelata shuga dị n’ọbara, gụnyere insulin.

N'ọnọdụ ọ bụla, ọ bụ naanị dọkịta na-aga ele anya nwere ike ịhazigharị usoro Glimecomb. Naanị ihe a chọrọ ka onye ọrịa ahụ dọọ ya aka na ntị n’oge n’oge gbasara ọgwụ ndị ọ na-a orụ ma ọ bụ n’atụmatụ ị ga-ewere.

Nsonaazụ

Glimecomb nwere ndepụta dị oke mma nke nsonaazụ ndị ọ na-akpata. Iji belata mmetụta ha na ahụ, ọ dị mkpa ịgbasochi usoro nnabata iwu akọwapụtara na ntuziaka.

A na-anabata glimecomb nke ọma. Nkagbu ya n'ihi anagide ya dị ụkọ.

Pharmacokinetics nke ọgwụ ọgwụ

Ejiri ọgwụ a mara na ọnụnọ nke pancreatic na mmetụta extrapancreatic.

Gliclazide na-akpali nguzobe nke insulin site na mkpụrụ ndụ beta nke pancreas ma na-enyere aka iwelie mmetụta nke sel anụ ahụ insulin na insulin homonụ. Ọzọkwa, onyinye ahụ na - enyere aka na - akpali enzyme intracellular - muscle glycogen synthetase. Ojiji nke gliclazide na-enyere aka weghachite mbido mbụ nke insulin ma belata postpradial hyperglycemia.

Na mgbakwunye na ịmetụta usoro nke carbohydrate metabolism, ojiji nke ogige a na-emetụta microcirculation ọbara, belata ọkwa nke nrapado na nchịkọta nke platelet, na-agbadata ọganihu nke parietal thrombosis, na-eweghachi ikike nkịtị nke vaskụla, na-ebelata nzaghachi nke mgbidi vaskụla na adrenaline n'ihe banyere microangiopathy.

Ojiji nke gliclazide na-enyere aka belata mmepe nke ọrịa mamịrị retinopathy mamịrị; na mgbakwunye, na ọnụnọ nke nephropathy, a na-achọpụta mbelata proteinuria.

Metformin bụ ogige kemịkalụ nke òtù biguanide. Ngwakọta a na - enyere aka belata shuga dị na plasma ọbara. A na-enweta nsonaazụ ahụ site na igbochi usoro nke gluconeogenesis na mkpụrụ ndụ imeju, yana site na ibelata ogo nke nnweta glucose site na lumen nke eriri afọ, yana site na ịkwalite nnabata nke glucose site na sel nke anụ ahụ. Ojiji nke metformin na-enyere aka belata ọbara triglycerides, cholesterol na lipoproteins dị ntakịrị. Mmeghe nke metformin n’anụ ahụ na-ebelata ma mee ka ahụ sie ike.

Ojiji nke metformin na enweghị insulin n'ime ọbara anaghị eduga na ngosipụta nke ọgwụgwọ ọgwụgwọ yana omume mmeghachi omume hypoglycemic. Ojiji nke metformin na-eme ka akwara fibrinolytic dị n'ọbara.

A na-enweta nke a site na iwepu ụdị inhibitor ụdị anụ ahụ.

Ihe ngosi na contraindications maka iji ogwu

Ihe ngosiputa maka ojiji nke Glimecomb bu udiri oria abuo nke mamonitus n’enweghi odi nma nke ihe eji aru aru na aru aru, ma n’enweghi ike obula igha aru ya na metaformine na glycazide.

A na-eji Glimecomb dochie usoro ọgwụgwọ a na-ejikwa mbụ na usoro Metformin na Glycoside, ma ọ bụrụ na ọkwa shuga dị n'ọbara kwụ chịm ma na-achịkwa nke ọma.

Glimecomb nwere otutu ogwu mgbochi megide iji ogwu.

Isi n'etiti contraindications bụ ihe ndị a:

1. Ahụ́ mmadụ na-enyocha onwe ya na-emetụta mmetụta nke metformin, gliclazide ma ọ bụ sulfonylureas ndị ọzọ. Na mgbakwunye, ekwesighi iji ọgwụ ahụ mee ihe n'ihu ọnụnọ nke ọgwụ ndị ọzọ maka ọgwụ ndị ahụ.
2. Ọnụnọ nke ọrịa shuga 1.
3. Ọnụnọ nke ketoacidosis nke ọrịa mamịrị, precca ọrịa mamịrị na ihe omume hypoglycemic.
4. Mmepe nke nnukwu nsogbu gbasara akụrụ.
5. Mmepe nke nnukwu ọnọdụ nke nwere ike ibute mgbanwe na arụ ọrụ nke akụrụ, mmepe nke akpịrị ịkpọ nkụ, ọrịa siri ike na ujo.
6. Mmepe nke ọrịa na-adịghị ala ala na nnukwu ọrịa, tinyere ihe omume hypoxia anụ ahụ.
7. Ihe omume nke akwara.
8. Ọrịa ọgbụgba.
9. Oge ịgba aka na oge ị ofụ ara.
10. Oge nchịkwa nke miconazole.
11. Ọrịa na-efe efe na usoro ịwa ahụ, oke ọkụ na nnukwu mmerụ ahụ, bụ nke n'oge a na-achọ ọgwụgwọ insulin ọgwụ.
12. Ọnụnọ nke ịhoụbiga mmanya ókè na ịxụbiga mmanya ókè.
13. Mmepe nke lactic acidosis.
14. Gbaso nri nri ala-carb.

Na mgbakwunye na ikpe ndị a, a machibidoro ọgwụ a iji mee ihe maka nyocha nke anụ ayodiin nwere ihe dị iche.

Ejila ọgwụ a gwọọ ọrịa shuga n’ebe ndị ọrịa ruru afọ iri isii, bụ ndị na-enwe ụdị nrụgide siri ike. Nke a bụ n'ihi oke ike nke mmepe nke lactic acidosis n’ebe ndị ọrịa dị.

Ekwesịrị ịkpachara anya mgbe ị na-a theụ ọgwụ ahụ ma ọ bụrụ na onye ọrịa ahụ nwere mgbaàmà ọrịa, ezughi oke na ịrụ ọrụ nke grenal adrenal, ọnụnọ nke hypofunction nke ntụgharị ihu, ọrịa thyroid, nke na-akpalite mmebi nke ọrụ ya.

Iji ọgwụ ọjọọ eme ihe

Ntuziaka maka Glimecomba na-achịkwa ma kọwaa n'ụzọ zuru ezu ọnọdụ niile enwere ike ị toụ ọgwụ na mgbe amachibidoro iji ọgwụ ahụ. Ntụziaka ahụ na-akọwapụta nsonaazụ niile ọ bụla na - apụta mgbe a na - eji ngwaahịa na usoro a tụrụ aro maka ojiji.

A na-eji ọgwụ ọnụ site n'oge nri ma ọ bụ ozugbo ọ gasịrị. Ọ bụ dọkịta na-esite na nyocha ka ọ dị maka ọgwụ a ga-anabata ya dabere na nsonaazụ nyocha a na njirimara nke ahụ onye ọrịa. A na-ekpebi ọ̀gwụ ọgwụ a dabere na ogo glucose dị n'ahụ onye ọrịa.

Ọtụtụ mgbe, usoro mbụ nke ọgwụ dọkịta gwara onye ọrịa ka ọ bụrụ mbadamba 1-3 kwa ụbọchị yana ntinye nke ọgwụ iji were kwụghachi ụgwọ maka ọrịa shuga. Ọ bụrụ na ịgbaso ndụmọdụ ndị ahụ, mgbe ahụ ọrịa shuga agbakọ ga-etolite.

Ọtụtụ mgbe, a ga-a drugụ ọgwụ ahụ ugboro abụọ n’ụtụtụ na mgbede. Ma oke onunu ogwu ogwu nwere ike ibu mbadamba ise.

Enwere ndụmọdụ pụrụ iche nke a ga-agbaso mgbe ị na-eme ọgwụgwọ Glimecomb:

• Ekwesịrị ịme ọgwụgwọ naanị na njikọta nri nwere obere kalori nwere obere carbohydrates,
• ndị ọrịa kwesịrị ịnata nri mgbe niile, nke na-edozi ahụ, nke kwesịrị ịgụnye ụtụtụ,
• iji zere mmepe nke mgbanwe nke hypoglycemia, mmadụ ga-eme nhọrọ nke usoro onunu ogwu,
• mgbe nrụgide anụ ahụ na nke mmetụta uche dị elu n'ahụ ahụ, ọ dị mkpa ịhazigharị ọgwụ a ga-ewere,

Mgbe ị na-eji ọgwụ dị ka Glimecomb eme ọgwụgwọ, ị kwesịrị ịhapụ ị beụ ihe ọholicụholicụ na-aba n'anya na nri nri nke nwere ethanol na otu ha.

Ekwesịrị ịkpachara anya mgbe ị na-eji ọgwụ ahụ eme ihe mgbe ị na-etinye ụdị ọrụ ndị ahụ chọrọ nlebara anya ngwa ngwa na mmeghachi omume ọsọ.

Omume mmetụta enwere ike

Mgbe ị takingụ ọgwụ ahụ, onye ọrịa ahụ nwere ike ịnwe mmetụta dị ukwuu nke nsonaazụ.

Na usoro nke metabolic, imebi usoro ị orụ ọgwụ ma ọ bụ mgbe ị na-eji nri ezughị ezu, ọgba aghara nwere ike ịmalite nke ahụ ga-eduga hypoglycemia. Ọnọdụ nke anụ ahụ na-eso ya na isi ọwụwa, ọdịdị nke mmetụta nke ike ọgwụgwụ, mmetụta siri ike nke agụụ, mmụba nke obi, ọdịdị nke akpịrị na nkwonkwo nkwaghari nke mmegharị.

Na mgbakwunye, n'ihe banyere ị violationsụ ọgwụ mgbochi ọrịa na onye ọrịa, ọnọdụ nke lactic acidosis nwere ike ịmalite, nke gosipụtara site na myalgia adịghị ike, iro ụra, afọ mgbu na mbelata ọbara mgbali.

Ọrịa ndị a nwere ike ịdakwasị na sistem nri nri:

1. na obi gị ụra
2. mmepe nke afọ ọsịsa,
3. ọdịdị nke mmetụta nke ibu dị na epigastrium,
4. dị ka ire nke ụrọ n'ọnụ,
5. nri riri
6. n’ọnọdụ ndị a na-adịghị ahụkebe, mmebi imeju dịka ịba ọcha n'anya, cholestatic jaundice na ụfọdụ ndị ọzọ tolite.

Ọ bụrụ na ọrịa imeju nwere akwara, a ga-akwụsị ọgwụ ozugbo.

N'ọnọdụ imebi usoro ị andụ ọgwụ na usoro ọgwụgwọ, mmepe nke mmekpa ahụ nke ịme ọbara na-ekwe omume.

Dịka nsonaazụ ndị ọzọ, onye ọrịa ahụ nwere ike ịmalite mmeghachi ahụ nfụkasị, nke gosipụtara n'ụdị itching, urticaria na friza faks.

Ọ bụrụ na onye ọrịa ahụ tolitere nsonaazụ site na ị takingụ ọgwụ, ị kwesịrị ị belata etu esi eme ya ozugbo ma ọ bụ kwụsị ị usingụ ọgwụ.