Ntụziaka Lizoril - (Lisoril) maka ojiji

Nkọwa nke metụtara 28.12.2014

• Aha Latin: Lisinopril
• Koodu ATX: C09AA03
• Arụ Ọrụ: Lisinopril (Lisinopril)
• Emeputa: Avant (Ukraine), Skopinsky Pharmaceutical Plant, ALSI Pharma, ZiO-Zdorovye, Severnaya Zvezda, Ozon LLC, Biochemist, Obolenskoye - ụlọ ọrụ ọgwụ, Canonfarm Production CJSC, VERTEX (Russia)

Isi ihe dị na ọgwụ ahụ bụ lisinopril akpọnwụwo. Mana, dabere na onye mepụtara ọgwụ ahụ, ihe mejupụtara ihe ndị ọzọ nwere ike ịdị iche.

Companylọ ọrụ ndị Ukraine bụ Avant na-ewepụta Lisinopril nwere ihe enyemaka dị ka ọka ọka,calcium hydrogen phosphate,iron oxide, mannitol,stereta magnesium.

Ma onye na-emepụta Russia ALSI Pharma na-emepụta ngwaahịa nwere ihe ndị ọzọ a: pregelatinized stachi,silloon dioxide colloidal,ntụ ntụ talcum,lactose monohydrate, microcrystalline cellulose,stereta magnesium.

Na mgbakwunye, ụdị ndị a tọhapụrụ ọgwụ ahụ dịka Lisinopril-Ratiopharm, Lisinopril-Astrafarm, Lisinopril Teva, Lisinopril Stada. Ha nwere ihe ndi ozo a:

• Lisinopril-Astrapharm - ọka ọka,silloon dioxide colloidal,mannitol,calcium hydrogen phosphate, stereta magnesium,
• Lisinopril-Ratiopharm - mannitol,calcium hydrogen phosphate, stereta magnesium, pregelatinized stachi, sodium croscarmellose (Mpempe 20 mg nwekwara pye PB-24824, na ọgwụ dị na mbadamba ụrọ 10 mg nwere PB-24823 ka ọ dị n'ime).

Lisinopril Stada nwere dịka ihe eji arụ ọrụ lisinopril hydrate. Na mgbakwunye, ihe ndị ọzọ: pregelatinized stachi,silicon oxide colloidal anhydrous, mannitol,stereta magnesium,ọka ọka, calcium phosphate gbanyere mmiri mmiri di n’ime ya.

Pharmacodynamics na pharmacokinetics

Mbadamba mbadamba Lisinopril ACEmụbaa ọdịnaya GHG endogenous vasodilating ma gbochie mgbanwe angiotensin I n'ime angiotensin II. Ha na-ebelata ntụgharị. arginine-vasopressinna endothelin-1, belata myocardial afterload, ngụkọta akwara na -akpata, ngụgụ akwara ọbara na mgbali ọbara. Na ndị ọrịa na- obi obara mụbaa nnabata maka mmega ahụ mmepụta obi. Nye aka na ọrụ ka ukwuu renin plasma.

Ọgwụ na-egbochi anụ ahụ renin-angiotensin sistemu obi, na - egbochi mpụta nke myocardial hypertrophy na dilatations ekpe ventricle ma ọ bụ na-enyere aka na-efu ha.

Mmetụta nke ọgwụ ahụ na-apụta mgbe ihe dị ka nkeji 60, na-abawanye ruo awa 6-7 wee dịgide otu ụbọchị. Oke antihypertensivensonaazụ ahụ na-egosipụta onwe ya n’oge ọ dị ọtụtụ izu.

A na-etinye ihe dị n'ọrụ ahụ ihe dị ka 25%. Oge nri adịghị emetụta mmịcha. Nkwurịta okwu na protein ndị dị na plasma dị ala. Ihe nọ n’ime ya abụghị ihe dị ndụ a na-agbanwe agbanwe ma kagbuo akụrụ na-agbanweghi. Oge iwepu ọkara ndụ bụ awa iri na abụọ.

Ihe ngbanwe

Ekwesighi iji ya hypersensitivity n'ihe ndị mejupụtara ya, lactation na tụụrụ ime.

Ọ bụ ekwesighi ịdepụta ọgwụgwọ a maka:

• hyperkalemia,
• mmeghachi omume anaphylactoid,
• collagenoses,
• ụkọ nri ụbụrụ,
• akụrụ na arụ ọrụ,
• ihe abuo stenosis akwara,
• ntụgharị akụrụ
• gout,
• nká
• Udeme nke Quincke n'ime akụkọ ihe mere eme,
• ụmkpụ ọkpụkpụ,
• hypotension,
• mgbanwe ndị na-egbochi mmụba ọbara sitere n’obi
• hyponatremia, yana mgbe ị na-eri obere sodium oriri,
• otu akụrụ akwara stenosis,
• hyperuricemia,
• afọ ụmụaka.

Nsonaazụ

Mmetụta ndị ọzọ nwere ike ịdị iche, ha na-esite na sistemụ na akwara dị iche iche:

Na mgbakwunye, ihe ngosi ndị a ga - ekwe omume: mmepe nke ọrịa, oke ibu, ọsụsọ, ọrịa shuga mellitusịzụlite antinuclear antibody titer na ọdịnaya urea, goutmmụba larịị creatinine, hyperkalemia, hyperuricemia, ahu ọkụ, nke ahu anataghi, akpịrị ịkpọ nkụ, hyponatremia.

Ọ bụrụ n ’mmetụta ọ bụla na-achọpụta, ị ga-agakwuru onye ọkachamara ozugbo.

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga ihe ókè, dịka iwu, na-apụta nnukwu akwara hypotension. Dịka ọgwụgwọ, a na-edozi saline nke anụ ahụ. A na-eme ọgwụgwọ Symptomatic.

Na mgbakwunye, ujo ga-ekwe omume, hyperventilation, nnukwu akwara ọdịda, bradycardia, ụkwara, amaghị ihe ọ bụla electrolytes n’ime ọbara tachycardiankuchi obi anya ntughariinwe ụjọ.

Ekwesịrị ịkagbu ọgwụ ahụ. Ọ bụrụ na onye ọrịa maara, ha na-agbari afọ, na-edunye onye ọrịa ahụ n'azụ ya site na iji aka ya wedata ya ala, bulie ụkwụ ya elu. Na mgbakwunye, ha na-enye enterosorbents.

Mgbe ị na-a medicationụ ọgwụ n’arụ ọgwụ ndị dị elu, onye ọrịa kwesịrị ịga ụlọ ọgwụ ozugbo. N ’ụlọ ọgwụ, a na-eme ọgwụgwọ maka ịnọgide na-ahụkarị mmanu mmanu, mmegharị ọbara, iku ume, iweghachite olu nke inye ọbara na arụ ọrụ akụrụ. Irè ịba ọcha n'anya. Gbalia nyochaa ihe ngosiputa nke oru di nkpa, yana ọkwa creatinine na electrolytesn'ime ọbara.

Mmekorita

Theakingụ ọgwụ ahụ antihypertensiveogwu nwere ike akpasu iwe mmata antihypertensive utịp.

Potassium-spure diuretics, dochie anya nri nnu na potassium, yana ọgwụ ndị nwere potassium na-eme ka o sie ike mmepe hyperkalemia.

Njikọ na blockers ACE na Ndị NSAIDna-eme ka ọ nwee ike ịrụ ọrụ akwara nwere nsogbu. N'ọnọdụ ndị a na-adịghị ahụkebe, ọ dịkwa ike hyperkalemia.

Na ngwa dị na ya loopback na thiazide diuretics fraits na njupụta antihypertensive emereme. Nke a na - ebulitekwa ohere nke ịrụ ọrụ ezumike n’ọrụ.

Indomethacin ma ọ bụ ego na estrogen yana lisinopril na - eduga nbelata antihypertensive omume nke ikpeazu. Nnabata n'otu oge Insulin nahypoglycemic ọgwụ nwere ike ibute hypoglycemia.

Njikọ ya na clozapine na-eduga n'ịbawanye ọdịnaya ya na plasma. Mgbe na-ewere carbonate lithium ọkwa ya na ọbara ọbara na-abawanye. Enwere ike ịgbakwunye nke a na ihe mgbaàmà nke ị intoụ mmanya lithium.

Ọgwụ na-abawanye utịp ethanol. Ihe mgbaàmà nke ịxụbiga mmanya ókè na-aka njọ. N'otu oge ahụ, mmụba ga-ekwe omume antihypertensive nsonaazụ nke lisinopril, ya mere ọ dị mkpa iji zere mmanya na-egbu egbu n'oge ọgwụgwọ a ọgwụ ma ọ bụ ịghara ị toụ ya n'ime awa iri abụọ na anọ mgbe ị drinkingụsịrị mmanya.

Ojiji nke ọgwụ a na njikọta maka ego ahu iziziọgwụ ọjọọ nyocha, antidepressants, akwara anụ ahụ ya na hypotensive mee ihe, yana ọgwụ ịrarụ ụra na-eduga n'ịba ụba antihypertensive mmetụta.

Thrombolytics mụbaa ihe hypotension akwara. Ekwesịrị iji nlezianya dekọọ ngwakọta a ma jiri nlezianya nyochaa ọnọdụ onye ọrịa ahụ.

Sympathomimetics imesibi ike antihypertensive mmetụta nke ọgwụ. Nchikota ya na ogwu na enye myelosuppressiveihe ịbawanye n'ihe egwu agranulocytosis na / ma ọ bụ neutropenia.

Jiri ya mee ihe Allopurinol, immunosuppressants, Procainamide, cytostatics, corticosteroids nwere ike ibute leukopenia.

Na dialysisusoro ọgwụgwọ ga-ekwe omume mmeghachi omume anaphylactoid ọ bụrụ na nke ngwaelu mmiri polyacrylonitrile metal nke nwere sọlfọ ọla.

Mpempe mwepụta, nkwakọ ngwaahịa na ihe mejupụtara Lizoril ®

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
14 pi. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.

Ndị pụrụ iche: stachi, mannitol, dicalcium phosphate dihydrate, magnesium stearate, iron dye oxide red.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
14 pi. - blisters (2) - ngwugwu nke kaadiboodu.

Ndị pụrụ iche: stachi, mannitol, dicalcium phosphate dihydrate, magnesium stearate, iron dye oxide red.

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
14 pi. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.

Ndị pụrụ iche: stachi, mannitol, dicalcium phosphate dihydrate, magnesium stearate, iron dye oxide red.

10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
14 pi. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Ihe mgbochi ACE. Ọ na-egbochi guzobe nke angiotensin II site na angotensin I. Ọ na-ebelata ọdịnaya nke angiotensin II ma na-eduga na mbelata nke ntọhapụ nke aldosterone. Na-ebelata mmebi nke bradykinin ma na-abawanye njikọta nke prostaglandin. Na-ebelata ngụkọta akwara vaskụla mkpụkọ, ọbara mgbali, preload, nsogbu akwara umeji, na - ebute mmụpụta nke obi ma nwekwuo ndidi myocardial maka nrụgide na ndị ọrịa nwere nkụda obi. Ọ na-eme ka akwara akwara dị elu karịa akwara. A na-akọwapụta ụfọdụ nsonaazụ site na nsonaazụ sistemụ renin-angiotensin. Site n'iji ogologo oge, hypertrophy nke myocardium na mgbidi nke akwara ndị dị n'ụdị resistive na-ebelata. Ọ na - eme ka ọkpụkpụ ọbara na ischemic myocardium dị mma. Ndị na - egbochi ACE na-eme ka ogologo ndụ dị ogologo na ndị ọrịa nwere nkụda obi ma na-ebelata ọganihu nke ọrịa ịhapụ ventricular ekpe na ndị ọrịa mgbe ike myocardial infarction na-enweghị ngosipụta ọgwụgwọ nke nkụda obi.

Mmalite nke ihe dị na elekere 1. A na-ekpebi mmetụta kachasị mgbe awa 6-7 gachara, oge - awa 24. Site n'ọbara mgbali elu, a na-ahụ nsonaazụ ahụ na ụbọchị mbụ mgbe mmalite nke ọgwụgwọ, mmetụta kwụsiri ike na-amalite mgbe ọnwa 1-2 gachara.

Mlọ ọgwụ

Bioavailability nke ọgwụ bụ 25-50%, na-ejighi ike na protein protein. C max na ọbara ka abatachara ka elekere asaa gachara. Iri nri anaghị emetụta mmịpụta.

Ikike zuru oke site na BBB na ihe mgbochi placental dị ala.

Lysoril adịghị metabolized ma wepụta na agbanweghi na mmamịrị ya. Otutu n’ime ya ka eweputara n’oge usoro mbu (nke dị irè T 1/2 - 12 awa), nke ọdụ ụgbọ anya (T 1/2 dị ihe dịka awa iri atọ)

Usoro onunu ogwu na nhazi

N'ime. Na ọbara mgbali elu: ọgwụ mbụ bụ 5 mg otu ugboro n'ụbọchị, ọ bụrụ na ọ dị mkpa ruo 40 mg / ụbọchị. Na mkpọchi obi: ọgwụ mbụ bụ 2.5 mg, ma ọ bụrụ na ọ dị mkpa ruo 20 mg / ụbọchị. Na-emegide nzụlite nke imebi nguzo mmiri-electrolyte, ọgwụgwọ diuretic nke ọdịda akụrụ, ya na mgbali ume ọhụrụ, usoro mbụ bụ 1.25 mg / ụbọchị.

Mmegha nke otu nosological

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Ndebanye aha Lizoril

• P N014842 / 01-2003

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

Amachibidoro ịnyefe, detuo, kesaa ozi na enweghị ikike nke RLS-Patent LLC.
Mgbe ị na-ehota ihe ọmụma dị na peeji nke www.rlsnet.ru, njikọta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Ihe ngosi maka ojiji

Ọbara mgbali akwara (gụnyere Symptomatic), CHF, ọgwụgwọ oge nke nnukwu myocardial infarction na hemodynamically kwụsiri ndị ọrịa ike (dịka akụkụ nke ọgwụgwọ njikọta).

Dị ka akụkụ nke usoro ọgwụgwọ maka nnukwu ọrịa myocardial infarction (na awa iri abụọ na anọ mbụ, yana ezigbo hemodynamics).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, yana ọbara mgbali elu - 5 mg otu ugboro n'ụbọchị. Na enweghị mmetụta, a na-abawanye dose ahụ kwa ụbọchị 2-3 site na 5 mg gaa na nkezi usoro ọgwụgwọ nke 20-40 mg / ụbọchị (ịba ụba dose ahụ karịa 20 mg / ụbọchị anaghị ebute mgbada ọbara ọzọ). Oke kachasị kwa ụbọchị bụ 80 mg.

Site na HF - bido na 2.5 mg otu oge, mmụba ọgwụ nke 2.5 mg mgbe ụbọchị 3-5 gachara.

N'ime ndị agadi, a na-ahụkarị mmetụta na-adịte aka hypotensive, nke a na-ejikọ ọnụ na mbelata mkpịsị lisinopril (a na-atụ aro ịmalite ọgwụgwọ na 2.5 mg / ụbọchị).

Na ọdịda akụrụngwa na-adịghị ala ala, nchịkọta na-apụta na mbelata nke mkpochasị ihe na-erughị 50 ml / min (a ga-belata ọnụọgụ ya ugboro abụọ, na CC erughi 10 ml / min, a ga-belata dose ahụ site na 75%).

Site n'ọbara mgbali elu na-adịgide, a na-egosi ọgwụgwọ ọgwụgwọ ogologo oge na 10-15 mg / ụbọchị, na nkụchi obi - na 7.5-10 mg / ụbọchị.

Ntụziaka pụrụ iche

Achọrọ nlekọta elebara anya mgbe ị na-edegara ndị ọrịa nwere akwara akwara ma ọ bụ stenosis nke akwara akwara akwara (ikekwe mmụba nke urea na creatinine n'ọbara), ndị ọrịa nwere ọrịa obi na-arịa ma ọ bụ ọrịa ụbụrụ, nwere nkụda mmụọ obi (enwere ike ịnwe hypotension, myocardial infarction, stroke). N'ime ndị ọrịa nwere nkụchi obi, hypotension akwara nwere ike ibute ọrụ ndị na-arụ ọrụ na-arụ ọrụ nke ọma.

Mgbe ị na-eji ọgwụ ndị na-ebelata ọbara ọgbụgba na ndị ọrịa nwere nnukwu ịwa ahụ ma ọ bụ n'oge mgbatị ụkwụ, lisinopril nwere ike igbochi guzobe angiotensin nke abụọ, nke abụọ na-ewe iweghachi ihe na-akpata.

Emebeghi nchekwa na arụmọrụ nke lisinopril na ụmụaka.

Tupu ịmalite ọgwụgwọ, ọ dị mkpa iji kwụọ ụgwọ maka ọnwụ nke mmiri na mmiri.

A na - egbochi ọgwụ n'oge ime ime, belụsọ na ọ gaghị ekwe omume iji ọgwụ ndị ọzọ ma ọ bụ na ha anaghị arụ ọrụ (a ga-eme ka onye ọrịa mara banyere ihe egwu nwere ike ibute nwa ebu n’afọ).

Ajuju, azịza, nyocha banyere ọgwụ Lizoril

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke kachasi banyere ogwu ahu di na ntuziaka nke ndi emeputaworo. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Mmetụta akụkụ

Site na usoro obi: mbelata ọbara mgbali, obi mgbu, ọ na - adịkarịghị - orthostatic hypotension, tachycardia, bradycardia, ọdịdị nke ihe mgbaàmà nke nkụda obi, na -akwụsị ebumnuche atrioventricular.

Site na sistem ụjọ: akpịrị ọgbụgba, isi ọwụwa, ike ọgwụgwụ, ụra, ụdọ na -eme ka uru ahụ nke aka ya na egbugbere ọnụ ya ghara ịdị ụkọ - ọrịa asthenic syndrome, ike ọgwụgwụ mmụọ, ọgba aghara.

Site na eriri afọ: ọgbụgbọ, dyspepsia, anorexia, mgbanwe uto, afọ mgbu, afọ ọsịsa, akpọnwụ akpọnwụ.

Akụkụ Hematopoietic: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anaemia (haemoglobin belatara, erythrocytopenia).

Site na sistem iku ume: dyspnea, bronchospasm, apnea.

Mmeghachi omume nfụkasị: edema angeoneurotic, rashes skin, itching.

Ndị na-egosi ụlọ nyocha: hyperkalemia, hyperuricemia, adịkarịghị - ọrụ mụbara nke transminases "hepatic", hyperbilibinemia.

Ndi ozo, okpukpo okpomoku, ike nwere obere, osighi ike - odida akwara odida, akwara mbu, myalgia, ahuhu, ire (ire, egbugbere onu, aka), isi akwara n’ile.

Njirimara ngwa

Achọrọ nlekọta elebara anya mgbe ị na-edegara ndị ọrịa nwere akwara akwara ma ọ bụ stenosis nke akwara akwara akwara (ikekwe mmụba nke urea na creatinine n'ọbara), ndị ọrịa nwere ọrịa obi na-arịa ma ọ bụ ọrịa ụbụrụ, nwere nkụda mmụọ obi (enwere ike ịnwe hypotension, myocardial infarction, stroke). N'ime ndị ọrịa nwere nkụchi obi, hypotension akwara nwere ike ibute ọrụ ndị na-arụ ọrụ na-arụ ọrụ nke ọma.

Mbelata ọbara mgbali elu n'oge a na-ebutekarị ya na mbelata na BCC kpatara ọgwụgwọ ọrịa, igbochi oriri nnu, mmịpụta, afọ ọsịsa, ma ọ bụ ọgbụgbọ.

A na-eme ọgwụgwọ na lisinopril na nnukwu myocardial infarction megide ndabere nke usoro ọgwụgwọ ọkọlọtọ (thrombolytics, ASA, beta-blockers). Dakọtara na nchịkwa iv nke nitroglycerin ma ọ bụ TTC nitroglycerin.

Mgbe ị na-eji ọgwụ ndị na-ebelata ọbara ọgbụgba na ndị ọrịa nwere nnukwu ịwa ahụ ma ọ bụ n'oge mgbatị ụkwụ, lisinopril nwere ike igbochi guzobe angiotensin nke abụọ, nke abụọ na-ewe iweghachi ihe na-akpata. Tupu ịwa ahụ (gụnyere ịwa ahụ eze), a ga-agwa onye dọkịta na-awa ahụ / ọgwụ na-akụnwụ ahụ banyere iji ihe mgbochi ACE.

Dabere na nsonaazụ nke ọmụmụ ọrịa, a na-eche na iji otu oge nke ACE inhibitors na insulin, yana ọgwụ hypoglycemic ọgwụ, nwere ike iduga mmepe nke hypoglycemia. A na-ahụkarị ihe egwu kachasị nke mmepe etolite n’izu ndị mbụ nke ọgwụgwọ njikọta, yana n’etiti ndị ọrịa nwere nsogbu gbasara akụrụ. Ndị ọrịa nwere ọrịa shuga chọrọ nlezianya nyocha nke glycemia, ọkachasị mgbe ọnwa mbụ nke iji onye na-egbochi ACE na-agwọ ya.

Tupu ịmalite ọgwụgwọ, ọ dị mkpa iji kwụọ ụgwọ maka ọnwụ nke mmiri na mmiri.

Ihe ndị dị ize ndụ maka mmepe nke hyperkalemia gụnyere ọdịda akụrụ na-adịghị ala ala, ọrịa shuga mellitus na oge nke potassium-sparing (spironolactone, triamteren ma ọ bụ amiloride), nhazi nke K + ma ọ bụ nnọchi nnu nwere K +. A na-atụ aro maka oge ịgbadoro ịgbanye uche nke K + na plasma ọbara.

N'ime ndị ọrịa na - a inụ ọgwụ mgbochi ACE n'oge enweghị ikike nchegharị na hymenopter, ọ bụ ihe na - adịghị ahụkebe na mmeghachi omume anaphylactoid na - egbu ndụ nwere ike ime. Ọ dị mkpa ịkwụsị ọrụ ya na onye na - egbochi ACE tupu ịmalite usoro nke enweghị nkụda mmụọ.

Mmeghachi omume anaphylactoid nwere ike ime mgbe a na-eme nrịba ama site na membranes na-elu-mmiri (gụnyere AN 69). Ọ dị mkpa ịtụle ihe ga-ekwe omume iji ụdị akpụkpọ ahụ ọzọ maka ịba ọcha ma ọ bụ ọgwụ ndị ọzọ na-egbochi mmiri.

Emebeghi nchekwa na arụmọrụ nke lisinopril na ụmụaka.