Melfor (Melfor)

N'ihi na enwere ike ịmalite imepụta ihe na-atọ ụtọ, a na-atụ aro nchịkwa capsule. Emume n'ụtụtụ. A na-etinye dose ahụ n'otu oge dabere na ngosipụta na ụzọ nchịkwa.
Mgbe ejiri ọnụ kwuo ya, otu ọgwụ bụ 0.25-1 g, ugboro nchịkwa yana oge ọgwụgwọ ọ dabere na njirimara ndị ahụ.
Site na nchịkwa iv, ọgwụ ahụ bụ 0-1-1 g 1 oge / ụbọchị, oge ọgwụgwọ ga-adabere na njirimara ndị ahụ.
A na-edozi 0,5 ml nke ọgwụ ntụtụ na ịta 500 mg / 5 ml na parabulbarly maka ụbọchị 10.

Ihe ngbanwe

Ihe mgbochi igbochi iji ogwu Emume bụ: ịba ụba intracranial nrụgide (gụnyere n'ihe banyere ntiwapụ nke mkpesa nsogbu, akpụ intracranial), afọ ime, lactation (inye ara), ụmụaka na ndị nọ n’afọ iri na asatọ, na-amụbawanye anya na meldonium.

Mmekọrịta na ọgwụ ndị ọzọ

Mgbe ejikọtara ya, meldonium na-eme ka ọrụ nke ọgwụ antianginal dị mma, ụfọdụ ọgwụ antihypertensive, cardiac glycosides.
Site na iji meldonium na oge a na nitroglycerin, nifedipine, alfa-blockers, ndị na-egbochi antihypertensive na vasodilaị na-agbanwe agbanwe, hyachension arterial nwere ike ịmalite (yana mkpokọta ndị a, a chọrọ ịkpachara anya).

Ihe ngosi maka ojiji

- Mbelata arụmọrụ, mgbatị ahụ dị elu, oge ọrụ iji mee ka nwughari ọsọ.

- Dị ka akụkụ nke usoro ọgwụgwọ dị mgbagwoju anya nke ọrịa obi na akwara obi, nkụchi obi na-adịghị ala ala, cardialgia megide ndabere nke diskimonal myocardial dystrophy.

- Dị ka akụkụ nke usoro ọgwụgwọ siri ike maka ihe ọghọm ụbụrụ (ọghọm ụbụrụ nke ụdị ischemic, ọkachasị usoro dị ala, ụkọ ụkọ ụkọ).

- Ngwọta zuru oke maka ịdọrọ ọrịa ị withdrawalụ mmanya.

- Nnukwu mgbu azụ, ọbara-ọbara na ọbara ọgbụgba nke etiologies dị iche iche, thrombosis nke akwara azụ na akụkụ ya, retinopathy nke etiologies dị iche iche (gụnyere ọrịa shuga na ọbara mgbali).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

Ngwọta maka ntụtụ

Mmụba nke uche na nke anụ ahụ: intravenly na 500 mg (5 ml) otu ugboro n'ụbọchị. Usoro ọgwụgwọ ya bụ ụbọchị 10-14. Ọ bụrụ na ọ dị mkpa, a na-amụgharị akwụkwọ ahụ ma emechaa izu abụọ. Maka ọrịa obi (dịka akụkụ nke usoro ọgwụgwọ): intravenously 500-1000 mg (5-10 ml). Usoro ọgwụgwọ ya bụ ụbọchị 10-14.

Ọrịa Ischemic cerebrovaskụla, ọkachasị usoro oge (dịka akụkụ nke ọgwụgwọ njikọta): 500 mg intravenously (5 ml) 1 oge kwa ụbọchị maka ụbọchị 7-10, mgbe ahụ a na-ewere ya ọnụ.

Ọkpụkpụ ụkọ ụbụrụ: 500 mg intramuscularly (5 ml) otu ugboro n'ụbọchị. Usoro nlekọta ya bụ ụbọchị 10-14, emesia ha ga-agbanye na nchịkwa ọnụ. Draụ mmanya na-egbu egbu: intravenously - 500 mg (5 ml) ugboro 2 n'ụbọchị. Ọgwụgwọ ya bụ ụbọchị 7-10.

Usoro ọgwụgwọ vaskụla nke fundus na retinal dystrophy: 50 mg (0.5 ml) injection na-achịkwa retrobulbarly na subconjunctively maka ụbọchị 10.

A na-ewere ya ọnụ, tupu nri, n'ihi mmetụta na-akpali akpali ọ bụ ihe amamihe dị na ya iji ya n'ụtụtụ.

Mmụba anụ ahụ 250 mg ugboro anọ kwa ụbọchị. Usoro ọgwụgwọ ya bụ ụbọchị 10-14. Ọ bụrụ na ọ dị mkpa, a na-emeghachi ọgwụgwọ ahụ ka izu abụọ gachara. Edere ndị na-eme egwuregwu 500-1000 mg ugboro abụọ kwa ụbọchị tupu ọzụzụ. Oge izi ihe dị na nkwadebe bụ ụbọchị 14-21, n’oge asọmpi - ụbọchị 10-14.

Site na ọrịa obi (dịka akụkụ nke ọgwụgwọ siri ike):

Stage angina pectoris - 250 mg ugboro atọ n'ụbọchị maka ụbọchị 3-4, mgbe ahụ, 250 mg ugboro atọ n'ụbọchị ugboro abụọ n'izu maka ọnwa 1-1.5.

Myocardial infarction: na oke oge - intravenously, ahụ n’ime site na 500 mg kwa ụbọchị, na-eji ọgwụ dum ugboro otu ugboro ma ọ bụ ugboro abụọ n’ụbọchị.

Ọrịa obi na-adịghị ala ala - 500-1000 mg otu ugboro n'ụbọchị. Ọgwụgwọ ya bụ izu isii na isii.

Cardialgia na ndabere nke dishormonal myocardial dystrophy 250 mg ugboro abụọ kwa ụbọchị. Usoro ọgwụgwọ ya dị ụbọchị iri na abụọ.

Ihe ọghọm Cerebrovascular: n'oge oke, intravenously, emesia 500 mg kwa ụbọchị, ọkacha mma na ọkara nke ụbọchị. Ọgwụgwọ ya bụ izu isii na isii.

Drakwụsị ọrịa ị alcoholụ mmanya (dịka akụkụ nke usoro ọgwụgwọ akọwapụtara) 500 mg 4 ugboro n'ụbọchị. Ọgwụgwọ ya bụ ụbọchị 7-10.

Omume ọgwụ

Ngwakọta ọrụ nke Melfora bụ meldonium - analog synthetic analog nke gamma-butyrobetaine, na-egbochi ọrụ gamma-butyrobetaine hydroxynase. N'ọnọdụ ischemia, ọ na-eweghachi nguzozi nke usoro nnyefe oxygen na oriri ya na mkpụrụ ndụ. Usoro nke ime ihe na-ekpebi ọdịiche nke mmetụta ọgwụ ya: ịba ụba arụmọrụ, ibelata akara nke nrụgide uche na nke anụ ahụ, ịgbalite anụ ahụ na mgbochi mkpali.

Ọ nwere mmetụta cardioprotective: ọ bụrụ na nnukwu mmebi mmebi ahụ na myocardium, na-ebelata ike mpaghara mpaghara necrotic, na-ebelata oge ịhazigharị. Site na nkụchi obi, ọ na-abawanye akwara myocardial, na-eme ka ịnagide mmega ahụ, ma belata ugboro ugboro ọgụ angina. Ọrịa ọgbụgba na-adịghị ala ala nke ọrịa ụbụrụ na-eme ka ọbara na-ekesasị mma nke ischemia, na-enye aka na mgbanye ọbara n'ọbara maka mpaghara ischemic. Ọ dị irè ma a bịa n'ihe banyere akụrụngwa nke vaskụla na dystrophic fundus. O nwere nsonaazụ tonic na sistemụ akwara na - ewepu nsogbu adịghị mma nke sistemụ ụjọ akwara na --akpata onwe ya na ndị ọrịa nwere mmanya na - egbu egbu na - ewepu ọrịa.

Nsonaazụ

Mmeghachi omume Allergic (redness, ọnya anụ ahụ, itching, swelling), dyspepsia, tachycardia, mbelata ma ọ bụ iwelie ọbara mgbali elu, oke iwe anaghị esi ike.

Site na oke mmachi nke Melfort, mbelata ọbara mgbali, isi ọwụwa, tachycardia, dizzness, adịghị ike izugbe na-amalite. Ọgwụgwọ bụ Symptomatic.

Leasedị mwepụta, nkwakọ ngwaahịa na ihe mejupụtara

5 pcs. - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
5 pcs. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.
5 pcs. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
5 pcs. - ngwugwu ọnya (4) - ngwugwu nke kaadiboodu.
5 pcs. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
5 pcs. - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu ọnya (4) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
10 PC - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu ọnya (4) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.
30 PC - ngwugwu ọnya (10) - ngwugwu nke kaadiboodu.
10 PC - iko polymer (1) - ngwugwu nke kaadiboodu.
20 nkp. - iko polymer (1) - ngwugwu nke kaadiboodu.
30 PC - iko polymer (1) - ngwugwu nke kaadiboodu.
40 pcs. - iko polymer (1) - ngwugwu nke kaadiboodu.
50 PC. - iko polymer (1) - ngwugwu nke kaadiboodu.
100 pcs - iko polymer (1) - ngwugwu nke kaadiboodu.

Ngosiputa ogwu

Maka nchịkwa ọnụ ma ọ bụ nchịkwa: dị ka akụkụ nke usoro ọgwụgwọ mgbagwoju anya nke ọrịa obi obi (angina pectoris, infarction myocardial), nkụchi obi na-adịghị ala ala, dishormonal cardiomyopathy, dị ka akụkụ nke usoro ọgwụgwọ nke nnukwu ọrịa na-arịa ọrịa ụbụrụ (ụbụrụ na ụkọ ụbụrụ), belata arụmọrụ, mgbatị anụ ahụ. (gụnyere na ndị na-eme egwuregwu), oge ọmụmụ ihe iji mee ka nwughari ha dịkwuo elu, wepụ ọrịa na-egbu egbu na-egbu egbu (yana yana usoro ọgwụgwọ a ,ụrụma, mmanya ZMA).

Maka nchịkwa parabulbar: ọgba aghara ọbara na retina, hemophthalmus na ọnya azụ nke etiologies dị iche iche, thrombosis nke akwara azụ na akụkụ ya, retinopathy nke etiologies dị iche iche (gụnyere ọrịa shuga na ọbara mgbali) - naanị maka nchịkwa parabulbar.

Usoro usoro onunu ogwu

N'akụkụ ihe nwere ike imepụta mmetụta na-akpali akpali, a na-atụ aro iji ya n'ụtụtụ. A na-etinye dose ahụ n'otu oge dabere na ngosipụta na ụzọ nchịkwa.

Mgbe ejiri ọnụ kwuo ya, otu ọgwụ bụ 0.25-1 g, ugboro nchịkwa yana oge ọgwụgwọ ọ dabere na njirimara ndị ahụ.

Site na nchịkwa iv, ọgwụ ahụ bụ 0-1-1 g 1 oge / ụbọchị, oge ọgwụgwọ ga-adabere na njirimara ndị ahụ.

A na-edozi 0,5 ml nke ọgwụ ntụtụ na ịta 500 mg / 5 ml na parabulbarly maka ụbọchị 10.

Ntụziaka pụrụ iche

Jiri mkpachapụ anya na ọrịa nke imeju na / ma ọ bụ akụrụ, ọkachasị ogologo oge.

Ọtụtụ afọ nke ahụmịhe na ọgwụgwọ nke nnukwu ọrịa myocardial infarction na angina na-akwụghị chịm na ngalaba ngalaba ahụ na-egosi na meldonium abụghị usoro izizi nke ọrịa coronary acute.

Mkparịta ụka ọgwụ ọjọọ

Mgbe ejikọtara ya, meldonium na-eme ka ọrụ nke ọgwụ antianginal dị mma, ụfọdụ ọgwụ antihypertensive, cardiac glycosides.

Site na iji meldonium na oge a na nitroglycerin, nifedipine, alfa-blockers, ndị na-egbochi antihypertensive na vasodilaị na-agbanwe agbanwe, hyachension arterial nwere ike ịmalite (yana mkpokọta ndị a, a chọrọ ịkpachara anya).

Usoro nke ime ihe

Ogwu ahu bu ana-eme ihe anakpo γ-butyrobetaine. Ọ nwere mmetụta dị ukwuu na njikọ nke carnitine na ngagharị nke ọdụdụ abụba site na mgbidi ụlọ, na-egbochi mkpokọta nke usoro acetyl coenzyme na acyl carnitine na mkpụrụ ndụ.

Pharmacodynamics nke ọgwụ na-agụnye mmụba na ọkwa nke arụmọrụ.

N'ime ọgwụgwọ nke ischemia, ọgwụ na-ebugharị ebugharị / oriri oxygen site na mkpụrụ ndụ, na-egbochi mmegharị nke ATP ma na-eme ka glycolysis. Site n'ibelata ọkwa nke carnitine, ọgwụ ahụ na-eme ka mgbasa nke gamma-butyrobetaine, nke nwere mmetụta vasodilating. Pharmacodynamics nke ọgwụ ahụ na-agụnye mmụba na ọkwa nke arụmọrụ, belata mmetụta nke nrụgide anụ ahụ / nke uche, ma melite mgbochi anụ ahụ / anụ ahụ.

Na oke nke ischemia, ogwu a na egbochi inyoghi inyoghi inyoghi na usoro nke necrotic, ma na - emekwa ka ndi ozo di ike. Na mgbakwunye, na-anụ ụda akwara nke etiti ma na-ahụ maka ịrụ ọrụ ya na mgbaàmà iwepụ mmanya.

A na-etinye ọgwụ ahụ n’ eriri afọ. Ya bioavailability ruru 78%.

A na-ahụta nlebara anya kachasị mgbe ejiri ọnụ na nchịkwa ọnụ gachaa nkeji 60-120.

N'oge mgbanwe biotransformation, ọgwụ ahụ na - eme ka mmadụ nwee metabolites na ahụ. Iwepu ọkara ndụ bụ site na awa 3 ruo 6. Ọgwụ ahụ akụrụ ya akụrụ.

Ngwakọta na ụdị ntọhapụ

N'elu ire, a na-enye ọgwụ ahụ n'ụdị capsules yana ọgwụ ntụtụ.

Erere 1 nwere:

• ihe na-arụ ọrụ (meldonium dihydrate) - 500 mg,
• ihe ndi ozo: 27.2 mg nke ahihia eji esi nri, 10.8 mg nke silloon silicon dioxide, 5.4 mg nke stearate calcium,
• ahụ okpu na isi ahu bu 98% gelatin na 2% titanium dioxide.

N'ime okpu ahụ bụ akwa hygroscopic ntụ ntụ.

N'elu ire, a na-enye ọgwụ ahụ n'ụdị capsules.

A na-etinye ihe ngwọta ahụ n'ime ampoules 5 ml, nke dị na ngwugwu sel na igbe kaadiboodu.

Nsonaazụ

Mmeghachi omume anụ ahụ na ọgwụ a ga - ekwe omume:

• nfụkasị ahụ: ọzịza, nchapu, ọbara ọbara (adịghị ahụkebe),
• Ọkpụkpụ afọ: ọnya ọnya anụ ahụ,
• CNS: mkpali nke mmeghachi omume psychomotor,
• CVS: mmụba / mbelata ọbara mgbali, tachycardia (n'ọnọdụ ndị anaghị adị oke).

Mgbe ị useụ ọgwụ ahụ, ọnya nwere ike.

Mmanya ndakọrịta

Akụkụ ike nke ọgwụ ahụ na-adị n’otu n’ime ihe dị ka awa iri na abụọ. Mgbe oge a gasị, ihe ọghọm nke mmeghachi omume ọjọọ nke mmekọrịta na ọgwụ ndị ọzọ anaghị anọkarị ma ọ bụ pere mpe.

Ntụziaka maka ị ofụ ọgwụ agaghị egbochi ịiningụ ya na mmanya. Agbanyeghị, ọ bụrụ na ụzọ ọ ga - esi rụ ọrụ iji wee gwọọ ọrịa ọ bụla nke akwara obi ma ọ bụ ọghọm ọria ahụ, onye ọrịa ahụ kwesịrị izere ị alcoholụ mmanya. Nke a bụ n'ihi ihe egwu nke mbelata na ọrụ ọgwụ ọgwụ ọgwụ. Njikọ yiri nke ahụ nwere ike ibute:

• oké ihe nfụkasị ngosipụta,
• tachycardia na angina pectoris,
• Ọnọdụ dyspeptik
• jumps n'ọbara.

Mgbe ị na-a theụ ọgwụ na mmanya, jumps n'ọbara nwere ike ịpụta.

Exbọchị mmebi

Ọ bụghị ihe karịrị afọ 4 site na ụbọchị emepụtara. A machibidoro ị drinkụ mmanya na ị medicineụ ọgwụ, ụbọchị nke ọ gwụla.

Mgbe ụfọdụ, ọ bụrụ na ọgwụ anaghị anọ ma ọ bụ adabaghị n'ihi contraindications, ị nwere ike ị attentiona ntị na nnọchi ya.

Ndị kachasị dị mma na ndị a ma ama bụ:

N'ihi enweghị mmeghachi omume na-adịghị mma n'oge nchịkwa na arụmọrụ, ọgwụ a na-enweta nyocha kachasị mma site n'aka ndị dọkịta na ndị ọrịa. Ọ na - enyere aka ụba mgbake na mgbake ume.

Gennady Oprishchenko (therapist), gbara afọ 40, Pushkino

Bothdị ọgwụ abụọ ahụ (capsules na ihe ngwọta) na-arụkwa ọrụ nhata na mgbaàmà ndọrọ ndọrọ, nsogbu mgbasa na GM na ọrịa ndị ọzọ. Ndi ọrịa nwere afọ ojuju maka ọnụ ọnụ ọgwụ maka ọnụ ala, ọ fọrọ nke nta ka ọ bụrụ na enweghị “mmetụta ọ bụla”.

Ekaterina Kolpakova (onye na-ahụ maka ọrịa), afọ 36, Yaroslavl

Ana m ede ọgwụ maka ọ bụghị naanị maka ndị ọrịa, kamakwa maka mmadụ nwere ahụ ike (ndị na-eme egwuregwu) iji meziwanye arụmọrụ. Ọ na-enyere aka nke ọma mgbe ha nwere nrụgide dị elu na nke anụ ahụ. A hụbeghị mmetụta na-adịghị ala ala n'oge ọrụ m niile.

Stanislav Smirnov, afọ 41, Ryazan

Ọgwụ ahụ nyeere nwanne m nwoke aka ịgbake n’a alcoụrụma. Dọkịta ahụ tinyere ọgwụ ndị ọzọ. Nwanne nwoke ahụ nwetara ọrụ ma bie ndụ ahụike.

Inga Stepanenko, 38 afọ, Sergiev Posad

Drunk wasụ ọgwụ gụrụ mmanya maka ọdịda nke akụkụ ụbụrụ. Mgbanwe ziri ezi na-apụta ngwa ngwa, enweghị ihe ndị na-emetụta ya agaghị eme ọ rejoiceụ ọ butụ. Ee, ọnụahịa ahụ dịkwa ọnụ ala.

Nyocha Melfor nyocha

Dọkịta ahụ tiri m Melfor ka ọ bụrụ ọgwụ ana-enweghị atụ. O wee jua m - ka m nye gi ọgwụ di oke ọnụ ma ọ bụ nke dị ọnụ ala.Gịnị kpatara m ji chọọ mbubata dị oke ọnụ? Kemgbe ọtụtụ ọnwa ugbu a, enyerela m ya ọgwụ wee nwee mmetụta ọfụma: ọ dịkwuo mfe ije ije, ọgụ angina anaghị enwe ike ịda. Na mkpokọta, enwere m obi anụrị na Melfor. Ekele pụrụ iche nye ndị dọkịta ghọtara na ndị lara ezumike nka nwere ike ha enweghị ego maka ọgwụ ndị dị oke ọnụ ma nye ha nhọrọ ịhọrọ!

Nkọwapụta dị mkpirikpi

Ihe atụ nke anụ ụlọ bụ obere ọgwụ ọgwụ Melfor (ọgwụ meldonium nọ n'ọrụ) - ọgwụ metabolic na-akpali usoro nke metabolic ma na - eme ka ume anụ ahụ dị. Ọ na-egbochi ịbanye na mitochondria nke abụba efu n'efu, si otú ahụ belata ọnụego oxidation nke ndị ikpeazụ. Melfore machibidoro ibufe nke ọdụdụ site na membranes mitochondrial, agbanyeghị, ọ na-eme ihe n'akụkụ a nke oke, ọ bụghị ịgafe naanị ọdụdụ ọdụdụ ogologo. Banyere ndị dị mkpụmkpụ mkpụmkpụ, ha nwere ike ịbanye na mitochondria ma mee ihe ọ bụla masịrị ha n'ebe ahụ (nke mbụ, anyị na-ekwu maka oxidation ha). N'adịghị ka trimetazidine, Melfore anaghị eme ka nchịkọta nke acids abụba buru ibu n'ime mitochondria. Na-emegide ischemia, ọgwụ a na-eweghachi nguzogide dị omimi na usoro oxygen na ebuga akwara na ike ya na saịtị nnyefe. N'otu oge ahụ, anaerobic glycolysis na-abawanye. N'okpuru omume nke melphor, vasodilator gamma-butyrobetaine na-amalite ịmụsi ọrụ ike. Ọgwụ ahụ na-eme ka arụmọrụ dị mma, na-ebelata ihe mgbaàmà nke ike ọgwụgwụ anụ ahụ na mgbatị psychomotion, na-eme ka ọnọdụ ahụ ghara ịlụ ọgụ, na-eme ihe na cellular na humudani, ma nwee mmetụta cardioprotective. Na oke mmebi ọgbụgba nke akwara obi, Melfor na -ebelata ogo nke necrosis, na-eme ka enweghachi ume ọhụrụ. Site na ezughi oke ọrụ nke obi, ọ na - eme ka uru akwara obi dịkwuo mma, na - eme ka ịgbalịsi ike ma belata ihe egwu angina pectoris. Site na ischemia nke ụbụrụ, melfor na-eme ka ọbara na-ekesa ụbụrụ na ischemic foci, na-ebute ọbara nke izizi gaa mpaghara ischemic. Mmadu aghaghi ighota uru doro anya nke iji Melfor mee ihe banyere oria mmuta nke aru (vaskụla na dystrophic).

A nwekwara ike iji ọgwụ ahụ mee ihe na mgbagwoju anya nke ndị ọrịa na-arịa ịhoụbiga mmanya ókè: ọ na-eme ka usoro akwara ndị dị n'etiti ya kwụsị ma wepụ nsogbu nke nsogbu ọrụ na akụkụ ya. Ihe edere na nsonaazụ ọma nke Melfor abụghị naanị na nke a: dịka ọmụmaatụ, ọgwụ ahụ gosipụtara mmetụta antioxidant, na-egbochi liroxidation lipid ma na-eme ka antioxidants endogenous, n'ihi nsonaazụ nke nrụgide oxidative na-adịzi. Na omumu ihe omumu, a gosiputara ike Melfor nwere ike ime ihe oma n’ile n’otutu endothelium ma mezie ubara akwara obara. Na mgbakwunye, achọpụtara na ọgwụ ahụ nwekwara mmetụta ndị ọzọ nke vaskụla: dịka ọmụmaatụ, ọ na-ewepụ spasms nke adrenal na angiotensin, na-ebelata oke mkpocha akwara na -akpata. Na mgbakwunye, melfor na-eme ka ịdị ọcha nke anụ ahụ dị na insulin, na-edozi metabolism nke lipids na glucose.

Melfor dị n'ụdị usoro ọgwụgwọ abụọ: capsules na azịza maka ọgwụ mgbochi. Ọ bụ ihe amamihe dị na ị takeụ ọgwụ n'ụtụtụ ahụ, dị ka ọ nwere ike bụrụ ihe na-atọ ụtọ. Dọkịta ahụ dobere ya otu otu. Dabere na nkwenye izugbe maka nchịkwa ọnụ, otu ọgwụ Melfor bụ 0.25-1 g, oge nchịkwa na oge nke ụzọ ọgwụ ahụ na-ekpebi site na ngosipụta ndị akọwapụtara. Site na nchịkwa ọgbụgba, ọgwụ kwa ụbọchị bụ 0-1-1 g, nke a na-elekọta oge. Parabulbar (site na akpụkpọ ahụ nkuchi nke ala) Melfor na-achịkwa n'ime 0,5 ml maka ụbọchị iri. Na mmechi, nkọwa dị mkpa: dị ka ọmụmụ banyere ụlọ ọgwụ na ahụmịhe nke ọgwụgwọ angina na-ejighị n'aka na nnukwu myocardial infarction egosila, Melfor abụghị onye mbụ na-ahọrọ ọrịa ọgbụgba akwara.

Ọgwụ Farmacology

Ndị na-eme ihe na-akpata metabolism, gamma-butyrobetaine analogue. Ọ na-egbochi gamma-butyrobetaine hydroxynase, na-egbochi njikọ nke carnitine na mbufe ọdụdụ ogologo site na mkpụrụ ndụ, ma na-egbochi mkpo nke ụdị abụba unoxidized abụba na mkpụrụ ndụ - usoro nke acylcarnitine na acylcoenzyme A.

N'okpuru ọnọdụ ischemia, ọ na-eweghachi nguzozi nke usoro nnyefe oxygen na oriri ya na mkpụrụ ndụ, na-egbochi imebi nke ụgbọ njem ATP, n'otu oge ahụ na-eme ka glycolysis, nke na-aga n'ihu na-enweghị ihe oriri oxygen ọzọ. N'ihi mbelata nke ịta carnitine, gamma-butyrobetaine nwere akụrụngwa vasodilating na-arụ ọrụ nke ọma. Usoro nke ime ihe na-ekpebi ọdịiche nke mmetụta ọgwụ ya: ịba ụba arụmọrụ, na-ebelata akara nke nrụgide uche na nke anụ ahụ, ịgbalite anụ ahụ na mgbochi anụ ahụ, mmetụta cardioprotective.

N'ihe banyere oke mbibi mbibi nke myocardium, ọ na-ebelata nguzo nke mpaghara necrotic ma belata oge nwughari. Site na nkụchi obi, ọ na-abawanye akwara myocardial, na-eme ka ịnagide mmega ahụ, ma belata ugboro ugboro ọgụ angina. Ọrịa ọgbụgba na-adịghị ala ala nke ọrịa ụbụrụ na-eme ka ọbara na-ekesasị mma nke ischemia, na-enye aka na mgbanye ọbara n'ọbara maka mpaghara ischemic. Irè maka vaskụla na dystrophic pathology. Ọ nwere mmetụta tonic na Central ụjọ usoro, na-ewepụ nsogbu nke akwara ozi na ndị ọrịa na-arịa ọrịa ị chronicụ mmanya na-adịghị ala ala nke nwere ọrịa ndọrọ ego.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, ọ na-abanye n'ime ngwa ngwa. Bioavailability bụ ihe dịka 78%. C_max na plasma na-enweta 1-2 awa mgbe nchịkwa. A na-emegharị ya n’ime ahụ mmadụ ka e mepụtara nnukwu metabolites abụọ nke akụrụ weputara. Ndi_1/2 bụ 3-6 awa ma dabere na dose.

Mkparịta ụka Melfor na ọgwụ ndị ọzọ

Ihe ize ndụ nke ịmalite hypotension na hyperension hyachension na tachycardia agafeghị oke na-apụta n'ihi otu oge nke Melfort na-eji ọgwụ ndị a:

• ọnọdụ vasodilators,
• alfa adrenergic blockers,
• ndị na-ahụ maka ọgwụ mgbochi
• nifedipine
• nitroglycerin.

Na mgbakwunye, mgbe ejikọtara ya na glycosides cardiac, ọgwụ antianginal, yana ụfọdụ ọgwụ ọgwụ antihypertensive, mmetụta ha ga-apụtawanye nke ọma.

Dodoụbiga ya ókè

N'ihe banyere ị increasedụ ọgwụ ole ka ọ ofụ ọgwụ, ịchọpụta adịghị ike nke isi ọwụwa, isi ọwụwa na nkụda mmụọ, mmepe nke tachycardia, na mbelata ọbara mgbali nwere ike ime. Ebe ọgwụ a nwere ọgwụ na-egbu egbu, ihe niile na-adịghị mma na-apụ n'anya ngwa ngwa mgbe usoro ọgwụgwọ ọkọlọtọ.

Usoro na ọnọdụ nchekwa

Ndụ nchekwa nke ọgwụ Melfor bụ ọnwa 24 site na ụbọchị ahapụ. Debe ya n'ime ebe akọrọ na ebe gbara ọchịchịrị maka ụmụaka.

Ọnọdụ ikuku ekwesịghị gafere +25 degrees Celsius.

Ọgwụ Melfor dị na ọgwụ ọgwụ. Nkezi ọnụ ahịa ya na Russia bụ 500-560 rubles.

Na ụlọ ọgwụ ndị Ukraine Nwere ike ịzụta ọgwụ Melfor na ọnụahịa nke hryvnia 200 ruo 250.

N'ọnọdụ ụfọdụ, ọ bụrụ na ọgwụ Melfor adabaghị adaba, ma ọ bụ enweghị ike iji ya, ị kwesịrị ị substa ntị na nnọchi ndị kachasị dị irè.

Ihe atụ ndị kachasị ewu ewu na Melfora gụnyere:

• Magnikor - nkwadebe dabere na acetylsalicylic acid na magnesium hydroxide, bu n'obi maka ọgwụgwọ nke ọrịa obi na-efe efe na nnukwu ọrịa na-adịghị ala ala,
• Pumpan - ọgwụ n'ụdị ọdịda na mbadamba nkume maka ọgwụgwọ dị omimi nke ọbara mgbali akwara, obi ike, arrhythmia na ụfọdụ ọrịa ndị ọzọ.
• Cordaflex - mbadamba nkume nwere ike ire ere nwere isi ihe dị n’ime nifedipine. Edere ọgwụ a maka nsogbu angina pectoris, nsogbu ọbara ọgbụgba, ọrịa obi na akwara, yana ọbara mgbali elu, nke nwere ogo dị iche,
• Corvitol - mbadamba nkume ndị nwere metoprolol. A na-eji ha maka ọgwụgwọ nke ọrịa obi na akwara, infarction myocardial infarction, angina pectoris, hyperthyroidism, ọbara mgbali, yana ọrịa arrhythmias,
• Kudesan bụ ọgwụ n'ụdị ọdịda na mbadamba ụrọ dabere na ubidecarinone. Isi ihe gosiri na eji ha bu ọrịa obi, akwara obi, ọrịa na akwara, yana oge mgbake mgbe ọ na-ata ahụhụ myocardial infarction.
• Amlipin bụ ọgwụ a na-ejikọ ọnụ nke dabeere na lisinopril na amlodipine, nke e mere maka ọgwụgwọ nke ọrịa obi na akwara ozi na ọbara mgbali elu nke ike dị iche iche.
• Bisoprol - mbadamba bisop bisoprol fumarate, bu n’obi maka ọgwụgwọ nke angina pectoris, ọrịa obi na-adịghị ala ala, yana oke ọbara mgbali.

N'ihi ịdị mma ya dị elu na enweghị mmetụta dị oke nsonaazụ ọ bụla, ọgwụ Melfor na-enweta nyocha dị mma site n'aka ndị ọrịa na ndị dọkịta. Enwere ike ịchọta nkọwa na njedebe nke edemede a.

Ndị tookụrụ ọgwụ rịrị ama na o nwere nsonaazụ bara uru na steeti sistem ụbụrụ na usoro nke mgbasa ụbụrụ. Ọ na - enye aka na mgbagha ngwa ngwa nke ike ma nwekwuo arụmọrụ.

Ọ bụrụ na ịnwere ahụmịhe nke ọgwụgwọ gị na iji ọgwụ Melfor, hụ na ị na-ekerịta echiche gị n'etiti ndị ọbịa ndị ọzọ na saịtị ahụ, na-ahapụ nyocha.