Metformin Richter: ntuziaka maka iji ọgwụ ahụ, ọnụahịa na contraindications

Metformin Richter: ntuziaka maka ojiji na nyocha

Aha Latin: Metformin-Richter

Koodu ATX: A10BA02

Ngwakọta ọrụ: metformin (metformin)

Onye na-emeputa ihe: Gideon Richter-RUS, AO (Russia)

Nkọwa na nwelite: 10.24.2018

Ego dị n'ụlọ ahịa ọgwụ: site na 180 rubles.

Metformin-Richter bụ ọgwụ hypoglycemic maka nchịkwa ọnụ, nke bụ akụkụ nke ìgwè biguanide.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta ọgwụ ahụ n'ụdị mbadamba ndị nwere ihe nkiri: biconvex, okirikiri (500 mg) ma ọ bụ oblong (850 mg), shei na akụkụ obe dị ọcha (pọọks 10. Na ngwugwu ogbe, ihe ngosi 1-4 ma ọ bụ isii n'ime igbe kaadi) .

Otu mbadamba 1 nwere:

ihe na-arụ ọrụ: metformin hydrochloride - 500 ma ọ bụ 850 mg,
ihe ndi ozo: polyvidone (povidone), copovidone, magnesium stearate, prosalv (colloidal silicon dioxide - 2%, microcrystalline cellulose - 98%),
Uwe mkpuchi: ọcha opadry II 33G28523 (hypromellose - 40%, titanium dioxide - 25%, lactose monohydrate - 21%, macrogol 4000 - 8%, triacetin - 6%).

Mlọ ọgwụ

Metformin na-akwụsịlata oge gluconeogenesis na imeju, na-ebelata nnabata nke glucose site na eriri afọ, na-enyere aka ịbawanye uru glucose na-emetụta ma na-eme ka ọ nwee mmetụta nke anụ ahụ na insulin. Na nke a, ihe ahụ anaghị emetụta mmepụta nke insulin nke β-sel nke pancreas ma ọ dịghị ebute mmepe nke mmeghachi omume hypoglycemic.

Ọgwụ na-ebelata ogo lipoproteins dị ntakịrị (LDL), triglycerides na cholesterol dị n'ọbara.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ site na eriri afọ (GIT). Oke kachasị nke ihe ahụ (C_max) n'ime plasma ọbara ka a na-ahụ mgbe awa 2.5 gachara, bioavailability bụ 50-60%. Nri na-ebelata C_max metformin na 40%, ma na-egbu oge imezu ya site na nkeji 35.

Olu nke nkesa (V_d) mgbe ị na-eji 850 mg nke ihe ahụ bụ lita 296-1012. Ejiri ngwa ọrụ na-ekesa mkpụkọ ngwa ngwa yana ogo dị ala nke na-egbochi protein protein.

Mgbanwe metabolic nke metformin dị obere, ọgwụ akụrụ ya akụrụ. N'ime ndị ahụ dị mma, iwepu ihe ahụ bụ 400 ml / min, nke dị okpukpu anọ karịa nke ikike creatinine (CC), nke a na-egosi na ọnụnọ nke tubular na-arụ ọrụ. Nkera-ndu (T_½) - 6.5 awa.

Ihe ngbanwe

ọrịa shuga, prema,
ọrịa mamịrị ketoacidosis,
Ọrịa akụrụ na-arụ ọrụ (CC erughị 60 ml / min),
ngosipụta ụlọ ọgwụ gosipụtara ọrịa dị iche iche n'ụdị na-adịghị ala ala nke nwere ike ịkpasu ihe omume hypoxia (nnukwu myocardial infarction, obi / akụkụ okuku ume na ọdịda, wdg),
ọrịa na-efe efe yana nsogbu nke ọrụ akụrụ nwere oke: ọrịa na-efe efe, ahụ ọkụ, hypoxia (ọrịa bronchopulmonary, ọrịa akụrụ, sepsis, ujo), akpịrị ịkpọ nkụ (megide ọgbụgbọ, afọ ọsịsa),
arụ ọrụ nke imeju,
lactic acidosis (gụnyere akụkọ ihe mere eme)
nsi mmanya na-egbu egbu, mmanya na-egbu egbu,
mmerụ ahụ na nnukwu ịwa ahụ dị iche iche e gosipụtara ọgwụ insulin,
iji maka opekata mpe, ụbọchị abụọ tupu ụbọchị abụọ ka mmezu nke ihe ọmụmụ radioisotope na raa-ray, na-eji ọgwụ iodine nwere ntụnyere iche,
glucose-galactose malabsorption, ekweghị ekwe lactose, ụkọ lactase,
mkpa maka nri hypocaloric (ihe na-erughị 1000 kcal / ụbọchị),
ime na lactation,
ọgwụ mgbochi na akụkụ ọ bụla nke ọgwụ ahụ.

A naghị akwado Metformin Richter maka ndị ọrịa karịrị afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ.

Ngwongwo ogwu

Metformin-Richter bụ ọgwụ a na-eji agwọ ọrịa shuga na-enweghị insulin na-arịa ọrịa shuga. Ọgwụ ahụ nwere ike igbochi usoro metabolic na imeju, nke na-eduga n'ịdịbe glucose, na-ebelata nnabata dextrose site na eriri afọ, na-eme ka ikike anụ ahụ na akwara ahụ nwee protein protein nke pancreas.

Ọgwụ anaghị emetụta mmepụta nke insulin site na pancreas, ọ dịghịkwa eso akpata ihe ize ndụ nke hypoglycemia. Ọgwụ a anaghị enye aka maka mmụba nke ọdịnaya protein protein nke pancreas, nke nwere ike ibute oke ibu, yana ngosipụta nke nsogbu na ọrịa shuga. Ọgwụ na-enyere aka ibido bukwa ibu.

Metformin Richter na-agbadata mkpokọta nke triacylglycerides na lipids n'ọbara ọbara, na-ebelata usoro abụba abụba, na-akwalite mmepụta nke aliphatic monobasic carboxylic acid, na-enwe mmetụta dị mma na arụ ọrụ nke obi na arịa ọbara, na-egbochikwa mmebi nke nnukwu arịa na obere arịa ọbara na ọrịa mellitus.

Ejiri ọgwụ maka ọgwụ maka ime ihe, a na-enweta ọdịnaya kachasị elu mgbe awa 2.5 gachara. Oge awa isii agachara nchịkwa, ọgwụ ga-eji nwayọ wepuga ya n'ahụ, na -ebelata ihe ndị dị na ọgwụ ahụ na ahụ. Site n'iji ọgwụ eme ihe mgbe niile, ihe ndị dị na ọgwụ ahụ na ahụ adịghị agbanwe agbanwe, nke na-emetụta ike na usoro nke ọrịa ahụ. Mgbe ị na-a theụ ọgwụ n’oge nri, a na-ebelata nnabata nke Metformin-Richter.

Ngwakọta na ụdị ntọhapụ

A na-eme ọgwụ ahụ n'ụdị mbadamba, nke kpuchie ya na obere ihe nkiri. Akụkụ molọtọ nke ihe na-arụ ọrụ n’ime mbadamba nkume bụ 0,5 ma ọ bụ 0.85 gram. Ngwa ahụ nwere mbadamba 30 ma ọ bụ 120, na mgbakwunye, agbakwunyere ntuziaka maka ojiji Ihe mejupụtara ọgwụ ahụ bụ ihe ndị a:

metformin

stachi

magnesium stearic acid,

ntụ ntụ talcum.

Ihe ngosi maka ojiji

A na-atụ aro ọgwụ ahụ maka ndị ọrịa nwere ọrịa shuga na-abụghị insulin. A na-eji ọgwụ ahụ eme ihe dị ka otu ọgwụ na ọgwụgwọ, yana maka usoro ọgwụgwọ dị mgbagwoju anya. Na mgbakwunye, a na-enye ọgwụ ahụ ka ndị ọrịa nwere oke ibu n'oge ọrịa shuga, mkpa ọ dị ịchịkwa mkpo nke dextrose, polycystic ovary syndrome.

Nsonaazụ

Aụ ọgwụ nwere ike ibute nsonaazụ ndị ọzọ:

obi ọgbụgbọ

omume ịtọghe

gagging

mgbu afọ,

agụụ

uto nke metal n'ime onu.

Ọcha na-acha ọbara ọbara site na mgbasawanye nke capillaries,

ihe na-akpata ahihia nke cobalamin,

wedata mkpokoro nke cobalamin n'ime ọbara,

imebi usoro nke ịmịnye ọbara,

Ọrịa Addison-Birmer.

Andzọ na njirimara ojiji

Ọgwụ Metformin-Richter dị n'ụdị mbadamba ụrọ nke achọrọ maka nchịkwa ọnụ. Nweghị ike igbutu, gbaji, nkwari akụ, ịkụpịa ma ọ bụ mbadamba ire, a ga-emerụ ha kpamkpam, were mmiri ọ waterụ sufficientụ sachapụ ha. Usoro ọgwụgwọ a na-atụ aro kwa ụbọchị, yana oge ọgwụgwọ, ka ndị dibịa bekee nyochachara nyocha ahụ, nnwale ule na mkpebi nke ọhụụ gbasara ọrịa ahụ. Na mgbakwunye, a na-atụ aro maka ojiji ị theụ ọgwụ ahụ na ntuziaka maka ojiji. Iji belata ihe egwu dị na nsonaazụ ya, ọ dị mkpa iji kewaa usoro ị na-atụ aro kwa ụbọchị n'ọtụtụ usoro onunu ogwu. Usoro ọgwụgwọ na mbadamba ụrọ nwere ọgwụ mgwoagha nke 500 mg: Usoro a na-atụ aro kwa ụbọchị bụ 500-1000 mg. Ka ubọchi iri nke 10-15 gachara, a na-atụ aro ịbawanye usoro onunu ogwu, dabere na ịta nke dextrose n'ọbara ọbara. Usoro kachasị elu kwa ụbọchị bụ 3000 mg. Usoro ọgwụgwọ na mbadamba ụrọ nwere 850 mg: Atụmatụ a na-atụ aro kwa ụbọchị bụ 850 mg ma ọ bụ otu mbadamba. Mgbe ubọchi 10-15 gachara, a na-atụ aro ka iwelie ahụ ike ka ọ dịkwuo elu, mgbe ọ nwesịrị dextrose n'ọbara. Usoro kachasị elu kwa ụbọchị bụ 2550 mg. Ọgwụ nwere monotherapy anaghị emetụta ikike iji ụgbọ ala, yana ọsọ nke mmeghachi omume psychomotor na ntinye. Site na ọgwụgwọ siri ike, ọ ka mma ịhapụ ịnya ụgbọ ala na ọrụ chọrọ otutu nlebara anya. A na-adụ ndị ọrịa ịka nká ume ka ha kọwaa ihe karịrị 1000 mg nke Metformin-Richter. Nweghị ike ịkọ ọgwụ maka ndị ọrịa nke afọ ha karịrị afọ 60, ọkachasị ma ọ bụrụ na enwere ọrịa ndị ọzọ na ihe ndị metụtara ekwe omume ị theụ ọgwụ. Cangaghị edenye ọgwụ Metformin-Richter na ọrịa akụrụ na ọrịa imeju.

Mmanya ndakọrịta

Agaghị ejikọta ọgwụ Metformin-Richter na iji ihe ọ alcoụ alcoụ na-aba n'anya eme ihe, n'ihi na nke a nwere ike ibute ịba ụba nke nsonaazụ na coctic lama. Na mgbakwunye, ihe ọ alcoholụ -ụ mmanya na-egbu egbu nwere mmetụta dị ukwuu na ọrụ nke akụkụ niile dị n'ime, na-amanye ha ịrụ ọrụ na ọnọdụ ha kawanyewanye, yabụ, ohere nke ịmalite ịba ụba hypoglycemia na-abawanye.

Mmekọrịta na ọgwụ ndị ọzọ

Ekwesighi iji Metformin-Richter ọgwụ ya na otutu ọgwụ ndị ọzọ:

Danazolum androgen na-eme ka mmadụ nwekwuo ohere ịba ụba glucose ọbara,

Chlorpromazinum nke kpụkọtara ọnụ na-agbadata mkpokọta dextrose,

ọgwụ sịntetik antidiabetic, nkwadebe nwere salicylic acid, ọgwụ hypoglycemic Acarbosum, insulin, ọgwụ mgbochi anti-mbufụt, monoamine oxidase inhibitors, angiotensin na-agbanwe enzyme inhibitors, fibrates, cytotoxic anticancer ọgwụ Cyclophosphamidum na-abawanye ihe ize ndụ

ọgwụ mgbochi steroid, ọgwụ mgbochi mkparịta ụka, ọgwụ mgbochi adrenal medulla Epinephrinum, sympathomimetics, glucagon, homonụ na-akpali akpali, diuretics, antipsychotics, ọgwụ ndị nwere isi belata glucose,

antihypertensive ọgwụ Nifedipinum na-eme ka ịta ụba nke ọgwụ ahụ dị ma gbochie oge iwepụ ọgwụ ahụ n'ahụ,

Ihe mgbochi Cimetidinum H2-histamine na-anabata ihe na-ebute lactic coma,

potassium-sparing diuretic Amiloridum, cardiac glycoside Digoxinum, alkaloid opium Morphinum, antiarrhythmic ọgwụ Procainamidum, alkaloid ogbugbo nke chininum osisi Chinidinum, Chininum antipyretic, Ranitidin ọgwụ antiulcer, ọgwụ diuretic nwere ike ịbawanye n'ihe ize ndụ nke mmepe ọgwụ ọgwụ Triamtum mmetụta.

Dodoụbiga ya ókè

Metformin-Richter na-enye ọgwụ nwere ike ibute mmanya egbu ma ọ bụrụ na usoro ọgwụgwọ a na-atụ aro ya na oge ọgwụgwọ a na-atụ aro gafere. Symptomatic akara nke ịdoụbiga mmanya ókè:

lactic acid coma na onwu ozo,

nsogbu akụrụ

obi ọgbụgbọ

gagging

omume ịtọghe

mbelata nke okpomoku

mgbu afọ,

olu mgbu

tachypnea

ọgba aghara vestibular

nsụhọ

Coma

ọnwụ. Ọ bụrụ na enwere ihe ịrịba ama nke ị withụ ọgwụ, ị kwesịrị ịgakwuru dọkịta gị nke ga-eweta nnwere onwe nke oge. Gaghị enwe ike iwepu ihe nrịba ama nke ịdoụbiga mmanya ókè na onwe gị, a gha ụlọ ọgwụ wee debe ya n'okpuru nlekọta nke dibia na-eleta. Should Tụ ọgwụ ahụ kwesịrị ịkwụsị ozugbo.

Ọgwụ ndị na-esote bụ analogues nke ọgwụ Metformin-Richter na Njirimara na mejupụtara ọgwụ:

Metformin-Richter,

Metformin-Teva,

Akpa,

Formetine,

Metfogamma,

Gliformin

Metospanin,

Siofor,

Glycomet,

Glicon

Vero-Metformin,

Orabet

Gliminfor

Glucophage,

NovoFormin,

Glibenclamide.

Ọnọdụ nchekwa

A na-atụ aro ka iji ọgwụ ahụ Metformin-Richter chekwaa ya n'ebe dịpụrụ adịpụ site na iru ụmụaka na ọkụ n'oge okpomọkụ na-erughị ogo 25 Celsius. Ndụ nchekwa nke ọgwụ ahụ bụ afọ atọ site na ụbọchị a rụpụtara. Mgbe ọ gwụchara ma debe nchekwa ahụ, enweghị ike iji ọgwụ a ma wepụsịa ya na ụkpụrụ ịdị ọcha. Ntụziaka maka ojiji nwere ozi zuru oke gbasara iwu na nchekwa nchekwa.

Akwụkwọ ikike ahịa ọgwụ LO-77-02-010329 nke June 18, 2019

Nsonaazụ

metabolism: adịkarịghị - lactic acidosis (iwepụ ọgwụ dị mkpa), na ogologo ụzọ - hypovitaminosis B₁₂ (n'ihi ịba)
usoro nri: enweghị agụụ, ụtọ dị n'ime ọnụ, vomiting, afọ ọsịsa, ọgbụgbọ, mgbu afọ, flatulence (a na-ahụkarị nsogbu ndị a na mbido ọgwụgwọ ma na-apụkarị, nwere ike belata ike ha site na iji antispasmodics, m-anticholinergics, antacids) , adịkarịghị - ịba ọcha n'anya, ụba ọrụ nke hepatic transaminases (apụ n'anya mgbe ịkwụsị ọgwụgwọ),
Usoro endocrine: hypoglycemia,
sisitemu nke hematopoietic: na obere ọnọdụ - megaloblastic anaemia,
Mmeghachi omume nfụkasị: itching, nchacha akpụkpọ ahụ.

Ntụziaka pụrụ iche

N'oge ọgwụgwọ na ọgwụ, ọ chọrọ ọ dịkarịa ala ugboro abụọ n'afọ (yana maka myalgia) iji guzobe uche nke lactate na plasma ọbara.

Ọ dịkwa mkpa iji chọpụta ọkwa nke serum creatinine otu ugboro n’ime ọnwa isii ọ bụla, nke a dị ezigbo mkpa maka ndị ọrịa agadi.

Y’oburu na mmepe nke ihe na-efe efe nke akwara akụkụ ma ọ bụ ọrịa bronchopulmonary chọpụtara n’oge nchịkwa nke metformin, ọ dị mkpa ịgwa dọkịta gị.

Mustnara ọgwụ a kwesiri ịkagbu awa iri asatọ na asatọ tupu oge awa iri asatọ na iteghete tupu urography, angiography intraven ma ọ bụ ọmụmụ ọ bụla ọzọ.

Enwere ike iji Metformin Richter mee ihe yana njikọta sulfonylurea, ọkachasị mgbe ị na-achịkwa mkpokọta glucose na ọbara.

N'oge usoro ọgwụgwọ, a na-atụ aro ka ịghara ị drinksụ ihe ọhanụ andụ na ọgwụ ethanol nwere. Into intoụbiga mmanya ókè na-eme ka ihe egwu lactic acidosis ka njọ, karịsịa na ọnụnọ nke imeju, na-eso nri kalori ma ọ bụ agụụ.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Ojiji nke Metformin-Richter dị ka ọgwụ monotherapy anaghị emetụta ikike ịkwọ ụgbọala.

N'ihe banyere ojiji nke metformin na insulin, ọgwụ sulfonylurea na ndị ọzọ na antidiabet, enwere ike ịmalite ọnọdụ hypoglycemic, nke ikike ịchịkwa usoro mgbagwoju anya (gụnyere ụgbọ ala) na-akawanye njọ.

Ime na lactation

Ekwesighi ị drugụ ọgwụ a n’oge ime. N'ọnọdụ nke ịtụrụ ime n’oge ọgwụgwọ, yana n’oge ọ na-ezube, a ga-akwụsị Metformin-Richter ma kọọkwa ọgwụ insulin.

Ebe o nweghi ihe omuma banyere n’ime ka metformin banye n’ime mmiri ara, a na - enye ya ndi nwanyi ndi na - enye ya ara. Ọ bụrụ na a ga-a drugụ ọgwụ n’oge a na-enye ya ara, a ga-akwụsị ịkwụsị inye ya ara.

Mkparịta ụka ọgwụ ọjọọ

Site na iji Metformin-Richter jikọtara ọnụ na ụfọdụ ọgwụ ọgwụ / nkwadebe, mmeghachi omume ndị na-esote nwere ike ịmalite:

Danazol - enwere ike ịmara mmetụta hyperglycemic nke ihe nnọchianya a, akwadoghị nchikota a, ma ọ bụrụ na ịchọrọ ọgwụgwọ Danazol na mgbe ị itụchara ya, ịkwesịrị ịgbanwe dose nke metformin ma na-achịkwa ọkwa nke glycemia,
angiotensin n'ịtụgharị enzyme inhibitors, oxytetracycline, monoamine oxidase inhibitors, ọgwụ mgbochi anti-mbufụt, salicylates, sulfonylureas, insulin, acarbose, fibroic acid, ndị na-egbochi beta-adrenergic igbochi, cyclophosphamide - hypoglycemic hypoglycemic,
chlorpromazine (antipsychotic) - mgbe ị na-a drugụ ọgwụ a kwa ụbọchị nke 100 mg, mmụba nke glucose n'ọbara na-abawanye na mwepụta nke insulin na-ebelata, na chlorpromazine na ọgwụ ndị ọzọ, yana mgbe ịkwụsị ọrụ ha, ekwesịrị idozi dose nke metformin ma nyochaa glucose ọbara,
cimetidine - mkpochapu metformin na - agbada, n'ihi nke a na - eme ka ihe egwu lactic acidosis kawanye njọ,
ọgwụ mgbochi, glucocorticosteroids, epinephrine, glucagon, sympathomimetics, nkwadebe nke iodine nwere homonụ thyroid, loop na thiazide diuretics, nicotinic aciderieri, ọgwụ phenothiazine - usoro hypoglycemic nke metformin belatara,
nifedipine - mmetụ ụba na C_max metformin na-akwụsịlata nke ikpeazụ,
ndị nwere ayodiin nwere ayodiin - na intravascular management nke ndị ọrụ ndị a, metformin cumulation nwere ike ime, nke nwere ike ibute lactic acidosis,
anticoagulants na-apụtaghị ìhè (ọgwụ coumarin) - a na-ebelata ike ha,
ranitidine, quinidine, morphine, amiloride, vancomycin, triamteren, quinine, procainamide, digoxin (ọgwụ cationic zoro ezo site na mkpo tubules) - mmụba na C ga - ekwe omume na ogologo ụzọ_max 60% metformin (n'ihi asọmpi maka sistemụ ebubata mmiri).

Ihe analogues nke Metformin-Richter bụ: Glyformin Prolong, Bagomet, Glyformin, Glucofage, Diasfor, Glucofage Long, Diaformin OD, Metfogamma 500, Metadiene, Metfogamma 850, Metformin-Kanon, Metformin, Metformin Zentiva Mens, Mpe nkwụ, , Metformin Sandoz, Metformin-Teva, Siofor 500, Formin, Sofamet, Siofor 850, Formin Long, Siofor 1000, Formin Pliva.

Nyocha na Metformin Richter

Dabere na ọtụtụ nyocha, Metformin Richter bụ ọgwụ dị irè nke na-edozi oke glucose n'ọbara, na-ebelata agụụ na agụụ maka ụtọ, ma na-enyere aka belata ma dozie oke ahụ.

Ọdịmma ọghọm nke ọgwụ ahụ, ọtụtụ ndị ọrịa gụnyere mmepe nke mmeghachi omume na-adịghị mma (nke kachasị site na eriri afọ) yana ọnụ ọgụgụ buru ibu nke contraindications. N'ihe fọrọ nke nta ka ọ bụrụ nyocha niile, a chọpụtara na Metformin-Richter bụ ezigbo ngwaọrụ dị oke mkpa na ọ dị mkpa ị were ya naanị dịka onye ọkachamara gwara ya.