Meldronate® (500 mg) Meldonium

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Mildronate. Na-enye nzaghachi site na ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara iji Mildronate na omume ha. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Analogs nke Mildronate na ọnụnọ nke usoro analogues dịnụ. Jiri iji gwọọ nkụchi obi na ọrịa strok ma melite metabolism na anụ ahụ na ndị okenye, ụmụaka yana n'oge ime na lactation.

Mildronate - ọgwụ na - eme ka metabolism dịwanye mma. Meldonium (ihe dị ka ọgwụ ahụ bụ Mildronate) bụ analog nke gamma-butyrobetaine, ihe ana achọtara n’ime sel mmadụ niile.

N'okpuru ọnọdụ nke ịba ụba, Mildronate na-eweghachi nguzozi n'etiti nnyefe na ikuku oxygen chọrọ nke mkpụrụ ndụ, na-ewepụ mkpokọta ngwaahịa metabolic na-egbu egbu na mkpụrụ ndụ, na-echebe ha pụọ ​​na mbibi, na-enwekwa tonic. N'ihi ojiji, ahụ ahụ na-enweta ike iguzogide ibu ahụ ma weghachi ikike nchekwa ngwa ngwa. N'ihi akụrụngwa ndị a, a na-eji Mildronate na-agwọ ọrịa dị iche iche nke usoro obi, ọbara na-enye ndị ụbụrụ, yana iwelie arụ ọrụ anụ ahụ na nke uche.

N'ihi mbelata nke ịta carnitine, gamma-butyrobetaine nwere akụrụngwa vasodilating na-arụ ọrụ nke ọma. Na nnukwu mmebi myocardial mechemic, Mildronate na-ebelata ike mpaghara mpaghara necrotic, na-ebelata oge ịhazigharị.

N’ime nkụchi obi, ọgwụ a na-abawanye akwara ozi myocardial, na-eme ka nnabata mmega ahụ dịrị, ma belata ugboro ugboro ọgụ angina.

Ọrịa ọgbụgba na-adịghị ala ala nke ọrịa ụbụrụ na-eme ka ọbara na-ekesasị mma nke ischemia, na-enye aka na mgbanye ọbara n'ọbara maka mpaghara ischemic.

Irè maka vaskụla na dystrophic pathology.

Ọgwụ a na - ewepụ nsogbu nke akwara ozi, na - ebulite n ’ị ofụ mmanya na - egbu egbu ogologo oge n’ebe ndị ọrịa nwere ọrịa ịlisụ mmanya na - adịghị ala ala nke nwere ọrịa ndọrọ ego.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ ngwa ngwa site na nri diges. Ọ bụ metabolized n'ime ahụ ya na imepụta metabolites abụọ dị mkpa nke akụrụ wepụtaara.

Ihe na-egosi

• na usoro ọgwụgwọ nke ọrịa obi na-egbu egbu (angina pectoris, infarction myocardial), nkụchi obi na-adịghị ala ala, dishormonal cardiomyopathy,
• na usoro ọgwụgwọ siri ike nke ọrịa ụbụrụ na-arịa oke ọrịa (ọrịa strok na ụkọ nri ụbụrụ),
• belata arụmọrụ
• nrụgide anụ ahụ (gụnyere n'etiti ndị na-eme egwuregwu),
• Mwepụ ọria na-egbu egbu (yana yana usoro ị forụ mmanya),
• hemophthalmus, ọnya azụ nke etiologies dị iche iche,
• thrombosis nke isi akwara nke retina na alaka ya,
• retinopathies nke etiologies dị iche iche (ọrịa shuga, hypertonic).

Dị Mwepụta

Capsules 250 mg na 500 mg (mgbe ụfọdụ, a na-akpọ ya mbadamba, ma ụdị Mildronate mbadamba adịghị adị)

Ngwọta maka inractions intravenous, intramuscular na parabulbar (injections in ampoules).

Ntuziaka maka usoro na usoro onunu ogwu

N'akụkụ ohere nke ịmalite inwe mmetụta na-akpali akpali, a na-atụ aro iji ọgwụ ahụ n'ụtụtụ.

Maka ọrịa obi dị ka akụkụ nke usoro ọgwụgwọ siri ike, a na-enye ya ọgwụ ka ọ dị n ’0,5-1 g kwa ụbọchị, ugboro ole a na-eji ya eme ihe bụ 1-2.

Site na cardialgia megide nzụlite diskimonal myocardial dystrophy, a na-edenye Mildronate ọnụ ọnụ 250 ugboro 2 kwa ụbọchị. Usoro ọgwụgwọ ya dị ụbọchị iri na abụọ.

N'ihe banyere ọghọm nke ọrịa ụbụrụ na oke oke, a na-a drugụ ọgwụ ahụ n'ọtụtụ ọgwụ (n'ụdị usoro onunu ogwu kwesịrị ekwesị - 500 mg otu ugboro maka ụbọchị 10), mgbe ahụ, ha gbanwere ị toụ ọgwụ ahụ site na 0-1-1 g kwa ụbọchị. Usoro ọgwụgwọ zuru oke bụ izu isii na isii.

N'ime nsogbu na-adịghị ala ala nke ọrịa ụbụrụ, a na-ewere ọgwụ ọnụ na 0-1-1 g kwa ụbọchị. Usoro ọgwụgwọ zuru oke bụ izu isii na isii. A na-edezi usoro ọmụmụ ugboro ugboro 2-3 ugboro n'afọ.

Maka ịgbalịsi ike na anụ ahụ, a na-enye ya ya n'ime ọgwụ 250 mpe 4 ugboro kwa ụbọchị. Usoro ọgwụgwọ ya bụ ụbọchị 10-14. Ọ bụrụ na ọ dị mkpa, a na-emeghachi ọgwụ ahụ ka izu abụọ gachara.

A na-atụ aro ka ndị na-eme egwuregwu jiri 0.5-1 g ugboro abụọ n'ụbọchị tupu ọzụzụ. Oge izi ihe dị na nkwadebe bụ ụbọchị 14-21, n’oge asọmpi - ụbọchị 10-14.

N’oge a na-a chronicụbiga mmanya ókè, a na-enye ya ọgwụ ọgwụ ọnụ 500 mg 4 ugboro n’ụbọchị. Ọgwụgwọ ya bụ ụbọchị 7-10.

Maka ọrịa obi dị ka akụkụ nke usoro ọgwụgwọ siri ike, a na-enye ọgwụ ahụ ka ọ dị 0,5-1 g kwa ụbọchị intravenously (5-10 ml nke ọgwụ ntụtụ na ịta 500 mg / 5 ml), ugboro ole a na-eji ya bụ 1-2 ugboro n'ụbọchị. Ọgwụgwọ ya bụ izu isii na isii.

N'ihe banyere ọghọm nke ọrịa ụbụrụ, a na-a iụ ọgwụ ahụ iv 500 mg otu ugboro n'ụbọchị iri, mgbe ahụ, ha na-agbanye na ị theụ ọgwụ ahụ n'ime (usoro kwesịrị ekwesị, 0,5-1 g kwa ụbọchị). Usoro ọgwụgwọ zuru oke bụ izu isii na isii.

N'ihe banyere nje vaskụla na ọrịa akwara dystrophic retinal, Mildronate ka a na-ahụ maka parabulbarly na ntụtụ 0,5 ml maka ntụtụ na mkpokọta 500 mg / 5 ml maka ụbọchị iri.

Maka nrụgide uche na nke anụ ahụ, a na-edenye iv 500 mg otu ugboro n'ụbọchị. Usoro ọgwụgwọ ya bụ ụbọchị 10-14. Ọ bụrụ na ọ dị mkpa, a na-emeghachi ọgwụ ahụ ka izu abụọ gachara.

N’oge a na-a chronicụbiga mmanya ókè, a na-edenye ọgwụ ahụ iv 500 mg 2 ugboro n’ụbọchị. Ọgwụgwọ ya bụ ụbọchị 7-10.

Mmetụta akụkụ

• tachycardia
• mgbanwe n'ọbara
• ntụgharị uche uche,
• isi ọwụwa
• ọrịa dyspeptik
• Mmeghachi omume nfụkasị (nchapu nke anụ ahụ, ihe ọkụ ma ọ bụ ọnya, ọnya akpụkpọ, ọzịza),
• adighi ike
• ọzịza.

Ihe ngbanwe

• ụba intracranial mgbali (gụnyere n'ihe nke ntiwapụ ntiwapụ nke oke mmiri, oke nwere oke nke intracranial),
• ụmụaka na ndị na-eto eto nọ n’agbata afọ 18,
• hypersensitivity na ọgwụ.

Ime na lactation

Ekwuputaghị nchekwa nke iji Mildronate n'oge afọ ime. Iji zere mmetụta ọjọọ na nwa ebu n’afọ, ekwesighi ịkọ ọgwụ a n’oge di ime.

Amabeghị ma ọgwụ ahụ dị na mmiri ara ara. Ọ bụrụ na ọ dị mkpa iji Mildronate n'oge a na-enye nwata ara, a ga-akwụsị ịkwụsị inye ya ara.

Ntụziaka pụrụ iche

Ndị ọrịa nwere ọrịa imeju na akụrụ kwesịrị ịkpachara anya maka iji ọgwụ ogologo oge. Ọ bụrụ n’ịchọrọ ị useụ ọgwụ ogologo oge (ihe karịrị otu ọnwa), ị kwesịrị ịkpọtụrụ ọkachamara.

Ọtụtụ afọ nke ahụmịhe na ọgwụgwọ nke nnukwu ọrịa myocardial infarction na angina na-akwụghị chịm na ngalaba ngalaba ahụ na-egosi na Mildronate abụghị ọgwụ nke mbụ maka ọrịa coronary acute.

Iji Ọrịa edimụaka

N'ime ụmụaka na ndị nọ n'afọ iri na asatọ, etinyere ịdị irè na nchekwa nke Mildronate n'ụdị mkpuchi na injection.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Enweghị ihe akaebe nke mmetụta ọjọọ nke Mildronate na ọnụego mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

Mgbe ejikọtara ya, Mildronate kwalitere ihe nke ọgwụ ọgwụ antianginal, ụfọdụ ọgwụ antihypertensive, cardiac glycosides.

Enwere ike ijikọ Mildronate na ọgwụ antianginal, ọgwụ anticoagulants na ndị nnọchi antiplatelet, ọgwụ antiarrhythmic, diuretics, bronchodilators.

Mgbe ejikọtara ya na Mildronate nitroglycerin, nifedipine, alfa-blockers, ọgwụ antihypertensive na vasodilaị na-agbanwe agbanwe, tachycardia na-adịghị ala ala, hypotension nwere ike ịmalite (ọ kwesịrị ịkpachara anya mgbe ị na-eji nchikota a).

Analogs nke ọgwụ Mildronate

Anakpụrụ nke analogues nke na-arụ ọrụ:

• 3- (2,2,2-Trimethylhydrazinium) mmiri nke nwere mmiri,
• Vasomag
• Idrinol
• Cardionate
• Medatern
• Meldonium,
• Meldonius Eskom
• Meldonium na-ada mmiri,
• Mgbago,
• Midolat
• Trimethylhydrazinium propionate dihydrate.

Mpempe usoro onunu ogwu

Otu Capsule nwere

ike ihe - meldonium dihydrate 500 mg,

ndị mgbe ochie: stachi nduku akpọnwụ akpọnwụ, colloidal silicon dioxide, calcium stearate,

kapsuzu (ahu na okpu): titanium dioxide (E 171), gelatin.

Hard gelatin capsules Nke 00 ọcha. Ọdịnaya bụ ntụ dị ọcha nke nwere akwa na-ada mba. Ntụ ntụ ahụ bụ hygroscopic.

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe otu nchịkwa ọnụ nke meldonium, plasma ịta (Cmax) na mpaghara dị n'okpuru oge ịta (AUC) na-abawanye na oke na ntinye. Oge ị ga - erute ịtalata plasma kachasị (tmax) bụ 1-2 awa. N'iji ya mee ihe ugboro ugboro, a na-enweta ndọta plasma ịhazigharị n'ime awa 72 ruo awa isii ka emechara ọgwụ nke mbụ ahụ. Nnukwu meldonium na plasma ọbara dị mfe. Nri na-ebelata oriri nke meldonium n’enweghi agbanwe Cmax na AUC.

Meldonium sitere n'ọbara ọbara na-agbasa ngwa ngwa. Njikọ protein na Plasma na-abawanye mgbe oge nchịkwa gasịrị. Meldonium na metabolites ya meriri ihe mgbochi placental. Emebeghị nnyocha nke meldonium na mmiri ara ara mmadụ.

Meldonium bụ ọkachasị metabolized na imeju.

Ihe nnochi anya ntaramahụhụ na-arụ ọrụ dị mkpa na excretion nke meldonium na metabolites ya. Mwepu ọkara ndụ meldonium (t1 / 2) bụ ihe dịka awa anọ. Site na iji usoro ugboro ugboro, ọkara ndụ dị iche.

Ndị otu ọrịa pụrụ iche

Ndị okenye na-arịa ọrịa

O kwesiri iji belata ogwu nke meldonium n’ebe ndi agadi noria nwere nsogbu imeju ma obu akụrụ, nke nwere mmụba mara mma bioavailability.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Ndị ọrịa nwere nsogbu gbasara akụrụngwa, nke nweburu ike nwebisianya, kwesịrị belata dose ahụ. Enwere mmekorita nke realsorption nke akụrụngwa nke meldonium ma ọ bụ metabolites ya (dịka ọmụmaatụ, 3 - hydroxymeldonium) na carnitine, n'ihi nsachapụ nke akwara nke carnitine na-abawanye. Enweghi mmetụta dị na meldonium, GBB, yana ijikọ meldonium / GBB na sistemụ renin-angiotensin-aldosterone.

Ndị ọrịa nwere ọria imeju

Ndị ọrịa nwere ọrụ imeju na-arụ ọrụ, nke nwere ụba bioavailability pụtara, kwesịrị belata ọgwụ meldonium. Mgbanwe ndị na-egosi ọrụ imeju na ụmụ mmadụ ka etinyechara ọgwụ ọnụọgụ nke 400-800 mg. Enwere ike ịme abụba n'ime abụba n'ime sel akwara.

Enweghị data na nchekwa na ịdị irè nke ojiji nke meldonium na ụmụaka na ndị nọ n'afọ iri na asatọ), yabụ na ojiji nke meldonium n'ime otu ndị ọrịa a ka amachiri.

Mlọ ọgwụ

Meldonium bụ ihe ga-enyere aka na carnitine, analog nke aha gamma-butyrobetaine (GBB), ebe a na-eji nitrogen atọm dochie otu atọm.

N'okpuru ọnọdụ nke ịba ụba, meldonium na-eweghachi nguzozi n'etiti nnyefe na ikuku oxygen chọrọ nke mkpụrụ ndụ, na-ewepụ nchịkọta ngwaahịa metabolic na-egbu egbu na mkpụrụ ndụ, na-echebe ha pụọ ​​na mbibi, na-enwekwa tonic. N'ihi ojiji, ahụ ahụ na-enweta ike iguzogide ibu ahụ ma weghachi ikike nchekwa ngwa ngwa. N'ihi akụrụngwa ndị a, a na-eji meldonium na-agwọ ọrịa dị iche iche nke usoro obi, akwara ọbara na ụbụrụ, yana ịbawanye arụmọrụ anụ ahụ na nke uche. N'ihi mbelata nke ịta carnitine, GBB, nke nwere akụrụngwa vasodilating, na-arụ ọrụ nke ọma. N'ihe banyere oke mbibi ọgbụgba na myocardium, meldonium na-akwụsịlata nguzo nke mpaghara necrotic ma belata oge nwughari. Site na nkụchi obi, ọ na-abawanye akwara myocardial, na-eme ka ịnagide mmega ahụ, ma belata ugboro ugboro ọgụ angina. Ọrịa ọgbụgba na-adịghị ala ala nke ọrịa ụbụrụ na-eme ka ọbara na-ekesasị mma nke ischemia, na-enye aka na mgbanye ọbara n'ọbara maka mpaghara ischemic. N'ihe banyere nsogbu akwara ozi (mgbe ihe ọghọm nke ọrịa ụbụrụ, arụ ọrụ ụbụrụ, mmerụ isi, encephalitis nke akara), ọ na-emetụta usoro mgbake nke arụ ọrụ na ọgụgụ isi n'oge oge mgbake.

Ihe ngosi maka ojiji

Na usoro ọgwụgwọ dị mgbagwoju anya n'ọnọdụ ndị a:

ọrịa obi na akwara vaskụla: angina kwụsiri ike, obi na-arịa ọrịa na-adịghị ala ala (arụ ọrụ klas nke III-NYHA), ọrịa obi, akwara ozi nke obi na akwara vaskụla,

ọrịa ụbụrụ nke na-arịa oke ọrịa na-adịghị ala ala,

arụmọrụ belatara, anụ ahụ na nke mmụọ

n'oge mgbake site na ọrịa ụbụrụ, mmerụ isi na encephalitis.

Usoro onunu ogwu na nhazi

Tinye n'ime. Ejiri mmiri jupụta okpokoro isi ahụ. Enwere ike iji ọgwụ ahụ tupu nri ma ọ bụ mgbe nri gasịrị. N'inye ya na mmetụta na-akpali akpali, a na-atụ aro iji ọgwụ ahụ n'ụtụtụ.

Ndị okenye

Ọrịa obi na usoro akwara,ọghọm nke ụbụrụ

Ọgwụ bụ 500-1000 mg kwa ụbọchị. Enwere ike iji ụbọchị ọ bụla mee ihe n'otu oge ma ọ bụ kee abụọ. Oke kachasị kwa ụbọchị bụ 1000 mg.

Arụdala arụmọrụ, oge oke na oge mgbake

Ọgwụ bụ 500 mg kwa ụbọchị. Oke kachasị kwa ụbọchị bụ 500 mg.

Ogologo oge ọgwụgwọ bụ izu 4-6. Enwere ike ikwugharị usoro ọgwụgwọ ahụ ugboro abụọ n'afọ.

Ndị okenye na-arịa ọrịa

Ndị agadi nwere ọrịa imeju na / ma ọ bụ ọrụ akụrụ nwere ike belata ọgwụ meldonium.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Ebe ọ bụ na a na-ewepụ ọgwụ ahụ site na akụrụ, ndị ọrịa nwere ọrụ akwara nwere nsogbu site na obere ruo n'ogo kwesịrị iji obere meldonium mee ihe.

Ndị ọrịa nwere ọria imeju

Ndị ọrịa nwere nkwarụ hepatic dị nro na obere kwesịrị iji obere meldonium dị ala.

Onu ogugu nke umuaka

Enweghị data maka nchekwa na ịdị irè nke ojiji nke meldonium na ụmụaka na ndị nọ n'afọ iri na asatọ, ya mere ojiji nke ọgwụ a maka ụmụaka na ndị nọ n'afọ iri na ụma.

Nsonaazụ

- Hypersensitivity, nfụkasị dermatitis, rashes (izugbe / macular / papular), itching, urticaria, angioedema, mmeghachi omume anaphylactic

- Arousal, a ụjọ nke ụjọ, echiche uche, nsogbu ịrahụ ụra

- paresthesia, hypesthesia, tinnitus, vertigo, ọgbụgba, ọgba aghara gafere, nkụda mmụọ, ọnwụ nke mmụọ

- ngbanwe obi obi, palpitations, tachycardia / sinus tachycardia, atria fibrillation, arrhythmia, obi erughị ala / obi mgbu.

- mgbanwe na ọbara ọgbụgba, nsogbu ọbara ọgbụgba, hyperemia, pallor nke anụ ahụ

- akpịrị mgbu, ụkwara, ọnyụnyụ ọbara

- dysgeusia (uto otite na onu), agụụ, ilu, ọgbụgbọ, ọgbụgbọ, ọgbụgba, afọ ọsịsa, ọnya afọ, - azụ mgbu, adịghị ike akwara, olu mgbu.

- adịghị ike izugbe, ịma jijiji, asthenia, edema, akụkụ ihu, ọrịrị nke ụkwụ, mmetụta nke okpomoku, mmetụta nke oyi, ọsụsọ oyi.

- ihe ndọtị na electrocardiogram (ECG), osooso nke obi, eosinophilia

Ihe ngbanwe

- Hypersensitivity na ihe nọ n'ọrụ ma ọ bụ ihe ọ bụla inyeaka nke ọgwụ.

- mmụba na nrụgide intracranial (mebiri nke nje na-akpata etuto ahụ).

- nnukwu ịba ọcha n'anya na / ma ọ bụ ọdịda akụrụngwa n'ihi enweghị data nchekwa zuru ezu.

- afọ ime na lactation, n'ihi enweghị data gbasara ọgwụ na-eji ọgwụ eme ihe n'oge a.

- ụmụaka na ndị na-eto eto nọ n’agbata afọ 18, n’ihi ụkọ data gbasara iji ọgwụ n’oge ọgwụ a.

Mkparịta ụka ọgwụ ọjọọ

Na-emeziwanye nsonaazụ nke ndị ọrụ akwara mmiri, ụfọdụ ọgwụ antihypertensive, cardiac glycosides.

Enwere ike ijikọ ya na ọgwụ antianginal, ọgwụ anticoagulants, ndị na-egbochi antiplatelet, ọgwụ antiarrhythmic, diuretics, bronchodilators.

Meldonium nwere ike iwelie mmetụta nke ọgwụ nwere glyceryl trinitrate, nifedipine, beta-blockers, ọgwụ ndị ọzọ antihypertensive, yana vasodilators gbara gburugburu.

N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala na-ewere meldonium na lisinopril n'otu oge, ekpughere mmetụta dị mma nke ọgwụgwọ njikọta (vasodilation nke akwara isi, mmụba nke mgbasa oke na ịdị mma nke ndụ, mbelata mgbagha uche na nke anụ ahụ).

Mgbe ị na-eji meldonium na anotic acid iji kpochapụ mmebi nke ischemia / reperfusion, a chọpụtara mmetụta ọgwụ ndị ọzọ.

N'ihi otu oge iji Sorbifer na meldonium na ndị ọrịa nwere ụkọ erughị ala, ihe mejupụtara acids nke abụba n'ime sel ọbara.

Meldonium na-enyere aka iwepụ mgbanwe ọrịa na obi na-akpata azidothymidine (AZT), ma na-emetụtaghị mmeghachi omume nrụgide oxidative nke AZT kpatara, na-eduga ná nsị mitochondrial. Ojiji nke meldonium na AZT ma ọ bụ ọgwụ ndị ọzọ maka ịgwọ ọrịa immunodeficiency syndrome (AIDS) nwere mmetụta dị mma na ọgwụgwọ AIDS.

N'ime ule ọnwụ ethanol, meldonium belatara oge ụra. N'oge ihe mgbu nke pentylenetetrazole kpatara, a kwụsịrị mmetụta anticonvulsant mmetụta nke meldonium. N'aka nke ya, mgbe α-adrenoblocker yohimbine na dose nke 2 mg / kg na N- (G) -nitro-L-arginine synthase inhibitor na dose 10 mg / kg na-eji tupu ọgwụgwọ na meldonium, a na-egbochi mmetụta anticonvulsant nke meldonium kpamkpam. .

Doụbiga ihe ókè nke meldonium nwere ike ịkwalite cardiotoxicity nke cyclophosphamide kpatara.

Mbelata carnitine sitere na D-carnitine (isomer a na-eme ka ogwu ghara idi ike) -meldonium nwere ike iwelie akuko cardiotoxicity nke ifosfamide kpatara.

Meldonium nwere mmetụta nchedo banyere ọrịa obi kpatara indinavir na neurotoxicity nke efavirenz kpatara.

N'ihi mmepe nke tachycardia na-erughị ala na mgbatị ọbara, a kwesịrị ịkpachara anya mgbe ejikọtara ya na ọgwụ ndị nwere otu mmetụta, gụnyere ọgwụ ndị ọzọ nwere meldonium.

Ntụziaka pụrụ iche

Ndị ọrịa nwere ọrịa na-adịghị ala ala nke imeju na / ma ọ bụ akụrụ kwesịrị iji nlezianya na iji ọgwụ ogologo oge (a ga-enyocha ọrụ imeju na akụrụ).

Meldonium abụghị ọgwụ izizi maka ọrịa coronary syndrome.

Akụkụ nke nsonaazụ ọgwụ ahụ nwere ike ịnya ụgbọ ma ọ bụ usoro nwere ike ibute

Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọala ma ọ bụ igwe nwere ike ịdị ize ndụ.

Dodoụbiga ya ókè

Amaghị ọgwụ ịdoụbiga ọgwụ ike na meldonium, ọgwụ ahụ adịghị egbu egbu.

Site n'ọbara dị ala, isi ọwụwa, dizzness, tachycardia, na adịghị ike n'ozuzu ga-ekwe omume.

N'ihe banyere oke ịdoụbiga mmanya ókè, ọ dị mkpa ịchịkwa ọrụ nke imeju na akụrụ.

N'ihi nnabata ọgwụ a na-egbochi ọgwụ, ọ na-adị n'ọbara abụghị ihe dị mkpa.

Emeputa

JSC "Grindeks", Latvia

Adreesị nke ọgbakọ na-ahụ maka ókèala ahụRepublic nke Kazakhstan na-azọrọ n'aka ndị na-azụ ahịa na mma ngwaahịa

Onyinye nke JSC "Grindeks"

050010, Almaty, Dostyk Ave., akuku nke ul. Bogenbai Batyr, 34a / 87a, ọfịs No. 1

Mlọ ọgwụ

Meldonium (MILDRONAT ®) bụ analog nke aha gamma-butyrobetaine - ihe ana - ahụ n’ime sel niile nke mmadụ.

N'okpuru ọnọdụ nke ịba ụba, MILDRONAT ® na-eweghachi nguzozi n'etiti nnyefe na ikuku oxygen chọrọ nke mkpụrụ ndụ, na-ewepụ mkpokọta ngwaahịa metabolic na-egbu egbu na mkpụrụ ndụ, na-echebe ha pụọ ​​na mbibi, na-enwekwa tonic. N'ihi ojiji, ahụ ahụ na-enweta ike iguzogide ibu ahụ ma weghachi ikike nchekwa ngwa ngwa.

N'ihi njikwa ndị a, a na-eji ọgwụ MILDRONAT to agwọ ọrịa dịgasị iche iche nke CVS, inye ọbara na ụbụrụ, yana iwelie arụ ọrụ anụ ahụ na nke uche. N'ihi mbelata nke ịta carnitine, gamma-butyrobetaine nwere akụrụngwa vasodilating na-arụ ọrụ nke ọma. N'ihe banyere nnukwu mmerụ ahụ dị na myocardium, MILDRONAT ® na-ebelata nguzo nke mpaghara necrotic ma belata oge nwughari. Site na nkụchi obi, ọ na-abawanye akwara myocardial, na-eme ka ịnagide mmega ahụ, ma belata ugboro ugboro ọgụ angina. Na ajọ ọrịa na-adịghị ala ala nke ụkwara akwara ọbara, ọgwụ MILDRONAT ® na-eme ka ọbara kesasị eburu n'uche ischemia, na-akwalite itinye ọbara n'ọbara maka mpaghara ischemic. Ọgwụ ahụ na-ewepụ nsogbu arụ ọrụ nke sistemụ akwara na ndị ọrịa nwere ọ chronicụlisụ na-egbu egbu na-arịa ọrịa mgbapụta.

Ngosiputa nke ogwu MILDRONAT ®

usoro ọgwụgwọ siri ike nke ọrịa obi obi (angina pectoris, infarction myocardial),

ọrịa obi na-adịghị ala ala na ọrịa obi na ndabere nke nsogbu dishormonal,

usoro ọgwụgwọ siri ike nke ọrịa na-adịghị ala ala nke ịnye ụbụrụ na ọnya (ọnya na ụbụrụ ụbụrụ),

hemophthalmus na ọnya azụ nke etiologies dị iche iche, thrombosis nke akwara azụ na akụkụ ya, retinopathy nke etiologies dị iche iche (ọrịa shuga, ọbara mgbali),

Iju oke na nke anụ ahụ (gụnyere na ndị egwuregwu) (ọgwụ nwere ike inye nsonaazụ dị mma mgbe ị na-eduzi njikwa doping (lee. "Ntuziaka pụrụ iche"),

nkwụghachi azụ n’arịa ị (ụ mmanya na-egbu egbu (yana yana ịgwọ ọrịa doro anya ị specificụ mmanya).

Ime na lactation

Emebeghị nchekwa nke ụmụ nwanyị dị ime, yabụ ejiri contraindicated iji zere nsogbu ndị nwere ike ịmetụta nwa ebu n’afọ.

Ntinye ọgwụ ọgwụ MILDRONAT ® nke mmiri ara ehi na nsonaazụ ya na ọnọdụ ahụike amụrụbeghị, yabụ, ọ bụrụ na ọ dị mkpa, a ga-akwụsị inye ara ya.

Mmekorita

Enwere ike ijikọ ya na ndị ọrụ antianginal, ọgwụ anticoagulants, ndị na-egbochi antiplatelet, ọgwụ antiarrhythmic, diuretics, bronchodilators.

Na-akwalite ihe nke obi glycosides.

N'iburu n'uche mmepe mmepe nke tachycardia na ọbara mgbali elu, a kwesịrị ịkpachara anya mgbe ejikọtara ya na nitroglycerin, nifedipine, alfa-blockers, ọgwụ ndị ọzọ na-egbochi ọgwụ na vasodilaị akụkụ, n'ihi na MILDRONAT ® na-eme ka mmetụta ha ka mma.

Mpempe mwepụta

Ngwọta maka intramuscular, intravenous na nchịkwa parabulbar, 100 mg / ml. 5 ml na vial nke iko enweghị agba nke klas hydrolytic nke m nwere ahịrị ma ọ bụ nkwụsịtụ.

5 amp ọ bụla. na ngwungwu emere site na ihe nkiri PVC ma ọ bụ ihe nkiri PET kpuchiri. Na 2 ma ọ bụ 4 (naanị maka ndị na-emepụta ZAO Santonika na HSBC Pharma sro) ngwugwu cell (pallets) na ngwugwu kaadiboodu.