Ọgwụ Lipothioxone: ntuziaka maka ojiji

mmiri doro anya site na ìhè odo ka acha odo odo na-acha edo edo.

Ngwongwo ogwu

Thioctic acid (alfa-lipoic acid) - antioxidant endogenous (na-egbochi radicals), na-emepụta ahụ n'ime ahụ site na oxidative decarboxylation nke alpha-keto acid. Dị ka coenzyme nke mitochondrial multienzyme ogige, ọ na-etinye aka na oxarative decarboxylation nke pyruvic acid na alfa-keto acid. Ọ na - enyere aka belata mkpụkọ glucose na ọbara ma mee ka mgbakwunye glycogen na imeju, yana imeri nguzogide insulin. Site na okike nke ndu ogwu ndu, o di nso na vitamin B sonyere na nhazi nke metabolism nke metabolism, na - akpali cholesterol metabolism, ma na - eme ka akwara di nma. O nwere hepatoprotective, hypoliplera, hypocholesterolemic, hypoglycemic utịp. Ọ na - eme ka akwara ozi trophic dịkwuo elu.

Mlọ ọgwụ
Site na nchịkwa ọgbụgba, oge ị ga-erute itinye uche kachasị bụ 10-11 min, oge ị kacha bụ 25-38 μg / ml, mpaghara dị n'okpuru oge ịta ihe dị ka 5 hg h / ml. Bioavailability bụ 30%.
Thioctic acid nwere “mbu ụzọ” sitere na imeju. Guzobe metabolites na - aputa ihe n'ihi nsị oxidation na conjugation n'akụkụ.
Olu nke nkesa dị ihe dịka 450 ml / n'arọ. Ọkpụkpụ nke Thioctic acid na metabolites ya na-apụta site na akụrụ (80-90%). Oge iwepụ ọkara ndụ bụ nkeji iri abụọ na ise. Mkpokọta plasma zuru ezu bụ 10-15 ml / min.

Usoro onunu ogwu na nhazi

A na-ezube ọgwụ a maka ịkwadebe ihe ngwọta maka infusion mgbe mbido mbu na ntụ ntụ nke isotonic sodium chloride.
N'ọdị siri ike nke ọrịa mamịrị ma ọ bụ polyneuropathy na-egbu egbu, 300-600 mg 1 kwa ụbọchị kwesịrị ka a ga-eme ya dị ka infusion intravenous drip infusion. Ekwesịrị ịnye infusion intravenous n'ime nkeji iri ise. A na-atụ aro ọgwụ ahụ iji mee ihe n'ime izu 2-4. Mgbe ahụ, ị ​​nwere ike ịga n’ihu were ọgwụ thioctic acid n’ime n’ime ntụtụ 300-600 mg kwa ụbọchị. Oge opekempe nke iji ọgwụ were ọnwa 3 bụ ọnwa.

Mmetụta akụkụ

Site na nchịkwa intravenous, nhịahụ, diplopia, oke ọbara n'ọbara na akpụkpọ ahụ, akpụkpọ ahụ (thrombocytopathy), mbufụt ọbara ọbara (purpura), thrombophlebitis adịkarịghị ekwe omume. Site na nchịkwa ngwa ngwa, mmụba nke nrụgide intracranial ga-ekwe omume (ọdịdị nke mmetụta nke oke na isi), iku ume ike. Nsonaazụ edepụtara edepụtara na-alapụ n'onwe ha.
Mmeghachi omume nfụkasị ahụ ga-ekwe omume: urticaria, mmeghachi omume nfụkasị sistemu (ruo etolite nke ujo anacticlactic).
Hypoglycemia nwere ike ịmalite (n'ihi mmụba glucose dị mma).

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe usoro onunu ogwu bu ntinye uche maka nkwadebe nke uzo eji etinye ihe: mmiri doro anya site na greenish rue n’oghu edo edo n’inwe ya (n’otu kaadiboodu ma obu ngwugwu plastik nke nwere ampoules 5 nke 12 ma obu 24 ml, na ntuziaka maka iji Lipothioxone).

Mejupụtara kwa 1 ampoule:

• ihe na - arụ ọrụ: acid thioctic (α-lipoic) acid - 300 ma ọ bụ 600 mg (n'ụdị nke meglumine thioctate - 583.86 ma ọ bụ 1167.72 mg, guzobere n'ihi mmekọrịta nke thioctic acid na meglumine),
• ihe ntinye aka (300/600 mg): shydum sodium anakpo - 6/12 mg, macrogol-300 - 2400/4800 mg, meglumine - rue pH 8-9 (12.5-35 mg / 25-70 mg), edetate disodium - 6/12 mg, mmiri maka injection - ruo 12/24 ml.

Mlọ ọgwụ

Acid Thioctic (α-lipoic) bụ antioxidant endogenous nke na - ejikọ ntụpọ n'efu, usoro nke arụ ya na - apụta na mgbe ọ na - eme oxidative decarboxylation nke α-keto acid. Dika coenzyme nke ogige mitochondrial multienzyme, thioctic acid na - etinye aka na oxidative decarboxylation nke α-keto acid na pyruvic acid.

Lipothioxone nwere hepatoprotective, hypolipidem, hypoglycemic na hypocholesterolemic. Site na okike nke ndu nke α-lipoic acid di nso na vitamin nke otu B.

Isi mmetụta nke thioctic acid:

• mbelata n'ọbara glucose,
• mmụba nke glycogen na imeju,
• meriri nguzogide insulin,
• isonye na mmezi nke carbohydrate na lipid metabolism,
• mkpali nke cholesterol metabolism,
• Ọ na - eme ka ọnọdụ akwara dịkwuo mma na ịkwalite trophism nke neurons.

Mlọ ọgwụ

A na-enweta ntinye kachasị nke thioctic acid na nchịkwa mgbochi n'ime nkeji 10-11, ọ bụ 0.025-0.038 mg / ml. Mpaghara dị n'okpuru usoro "ịta - oge"

0.005 mg h / ml. Bioavailability n'ogo nke 30%.

Nri ahụ nwere nsonaazụ nke izizi na-agafe imeju. Usoro nke usoro metabolite na-ejikọta ya na conjugation na oxidation nke yinye akụkụ.

450 ml / n'arọ. Cchụpụ ihe ahụ na metabolites ya na - aputa ihe site na akụrụ (site na 80 ruo 90%). Iwepu ọkara ndụ na-eme ka nkeji iri abụọ na ise. Mkpokọta plasma zuru ezu dị na 10-15 ml / min.

Lipothioxone, ntuziaka maka ojiji: usoro na usoro onunu ogwu

A na-edozi Lipothioxone n'ime ụdị nke infusions mgbe dilution na ngwọta isotonic sodium chloride.

N'okwu ndị dị egwu nke ọrịa, a na-ahụ maka azịza ya otu ugboro kwa ụbọchị na dose nke 300-600 mg ntapu maka nkeji 50.

Oge akwadoro iji ọgwụgwọ bụ izu 2-4. Na njedebe nke oge a, a na-eji usoro nchịkwa nke thioctic acid na-aga n'ihu n'ọgwụgwọ maka otu opekata mpe ọnwa 3.

Nsonaazụ

N'okwu ndị na-adịghị ahụkebe, megide mmalite nke iwebata Lipothioxone, enwere mmepe nke nsogbu n'ụdị ọdịdọ, diplopia, thrombophlebitis, ọnya ọbara na akpụkpọ ahụ na mucous membranes, mbufụt ọbara ọbara (purpura), thrombocytopathy.

Y’oburu na osisa ya ngwa ngwa, nsogbu iku iku ume na ubara ume intracranial nwere ike ime (gosiputara ya dika obi uto n’elu isi). Mmeghachi omume ndị a na-apụkarị n'anya nke onwe ha.

Urticaria, mmeghachi omume nfụkasị sistemụ (ruo nrịfu anaphylactic) nwere ike ime.

Bawanye elu ịba ụba glucose nwere ike ibute hypoglycemia.

Ntụziaka pụrụ iche

Ndị ọrịa nwere ọrịa shuga, ọkachasị na mbido ojiji nke Lipothioxone, chọrọ ka a na-enyochakarị glucose n'ọbara. Mgbe ụfọdụ, ọ ga-eji belata ọgwụ hypoglycemic agents.

A na-atụ aro ka ịghara ị drinkingụ mmanya n'oge ọgwụgwọ, ebe ọ na-ebelata mmetụta nke usoro ọgwụgwọ ahụ.

A ga-ewepụ ampoules site na ngwugwu naanị ozugbo tupu ejiri ya, ebe ọ bụ na Lipothioxone nwere nnukwu ọrụ nchekwa. N'oge ọgbụgba, ọ dị mma iji chebe vial a na-ahụ anya site na ikpughe ọkụ site na iji foil aluminom kpuchie ya ma ọ bụ itinye ya na akpa mkpuchi ọkụ.

Mgbe dilution, ekwesịrị iji lipothioxone maka awa 6, ma ọ bụrụhaala na echekwara ya n'ebe gbara ọchịchịrị.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

Na / n'ime (jet, ntapu), na / m.

Na ụdị polyneuropathies siri ike - iv nwayọ nwayọ (50 mg / min), 600 mg ma ọ bụ iv drip, na ntụgharị 0.9% NaCl otu ugboro n'ụbọchị (n'ọnọdụ dị oké njọ, ruo 1200 mg na-achịkwa) maka izu 2-4. Na ntinye akwụkwọ / ntinye ga-ekwe omume site n'enyemaka nke onye na-achọgharị ihe (oge nchịkwa - opekata mpe nkeji iri na abụọ).

Site na ntụtụ / m na otu ebe, oke ọgwụ ahụ agaghị agafe 50 mg.

Mgbe nke a gasịrị, ha na-agagharị na ọgwụgwọ ọgwụ maka ọnwa 3.

Omume ọgwụ

Coenzyme nke mitochondrial multienzyme ogige ndị metụtara na oxidative decarboxylation nke pyruvic acid na alfa-keto acid na-arụ ọrụ dị mkpa na nguzo ike nke ahụ. Site na okike nke ihe eji eme ihe ndu aru, thioctic (alfa-lipoic) acid yiri vitamin B .. Ọ bụ antioxidant endogenous. Na-ekere òkè na usoro nke lipid na carbohydrate metabolism, nwere mmetụta lipotropic, na-emetụta metabolism cholesterol, na-eme ka ọrụ imeju, nwee mmetụta detoxifying n'ihe banyere nsị na nnu dị arọ na nsí ndị ọzọ. A na-egosipụta mmetụta nke metabolism metabolism na mbelata mgbanye glucose ọbara na mmụba nke glycogen na imeju, yana imeri nguzogide insulin. Ọ na - eme ka akwara ozi trophic dịkwuo elu.

Ajuju, azịza, nyocha banyere ọgwụ Lipothioxone

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Analogs na ọnụ ahịa ọgwụ Lipothioxone

mbadamba mkpuchi

ngwakọta ngwakọta

mbadamba ihe mkpuchi

mbadamba mkpuchi

infusion ngwọta itinye uche

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

infusion ngwọta itinye uche

infusion ngwọta itinye uche

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mbadamba mkpuchi

azịza maka nchịkwa intraven

infusion ngwọta itinye uche

mbadamba ihe mkpuchi

mbadamba mkpuchi

mbadamba ihe mkpuchi

tinye uche maka mmezi maka nchịkwa intraven

infusion ngwọta itinye uche

infusion ngwọta itinye uche

infusion ngwọta itinye uche

mbadamba ihe mkpuchi

Ntuli aka: 76 dọkịta.

Nkọwa nke ndị zaghachirinụ site na icheiche:

Mmekọrịta na ọgwụ ndị ọzọ

Alfa lipoic acid (dị ka ihe ngwọta maka infusion) na-ebelata mmetụta nke cisplatin.
N'iji insulin na ndị ọzọ ọnụ nke hypoglycemic na-eme n'otu oge, a na-achọpụta mmụba na mmetụta hypoglycemic.
Alfa-lipoic acid na –eme ka osiso ike gwusi kompeni na molekulu (dika imaatu ihe banyere levulose) .

Mkparịta ụka ọgwụ ọjọọ

• cisplatin: a na-ebelata nsonaazụ ya,
• insulin na ọnya ọgwụ hypoglycemic ọzọ: a na-eme ka mmetụta hypoglycemic dịkwuo elu,
• Ngwọta glucose, ihe ngwọta Ringer, ihe na-emeghachi omume na disulfide na ìgwè SH (gụnyere ihe ngwọta ha): enweghị nkwekọrịta, ebe ọ bụ na usoro nke α-lipoic acid ogige mgbagwoju nke ụmụ irighiri shuga na-eme.

Nyocha nke Lipothioxone

Nyocha banyere Lipothioxone dị ole na ole. N'ọnọdụ ụfọdụ, ndị ọkachamara na-ahụ maka mmepe nke nsonaazụ ndị ọzọ, ọtụtụ mgbe n'ụdị hypoglycemia (maka usoro onunu ogwu nke 600 mg). A na-ahụtakwa nsogbu nri na mmụba n’ime enzymes imeju.

N'ime uru dị iche iche na-agakarị usoro dị mma maka usoro ọgwụgwọ yana ọnụ ahịa dị ọnụ.

Lipothioxone: ọnụ ahịa dị na ahịa ọgwụ dị n'ịntanetị

Lipothioxone 25 mg / ml itinye uche maka ihe ngwọta maka infusion 12 ml 5 PC.

Mmụta: Universitylọ akwụkwọ Mahadum Medical Ahụike Moscow nke mbụ aha ya bụ I.M. Sechenov, ọpụrụiche "General Medicine".

A na - emejupụta ozi gbasara ọgwụ ahụ, enyere ya aka ka ọ nweta ihe ọ bụla, ọ naghị edochi ntuziaka gọọmentị. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

N'oge ị na-arụ ọrụ, ụbụrụ anyị na-etinye oke nha anya ya na bọlbụ 10-watt. Yabụ na onyinyo nke oriọna dị n’elu isi gị n’oge ngosipụta nke echiche na-adọrọ mmasị adịghị anya n’eziokwu.

Ndị ọkà mmụta sayensị America mere nyocha na ụmụ oke wee kwubie na mmiri mmiri mmiri na-egbochi mmepe nke atherosclerosis nke arịa ọbara. Otu ìgwè na -a mụ mmiri dị ọcha, nke abụọ abụrụ mmiri ọ aụ juiceụ. N'ihi nke a, arịa nke ndị otu nke abụọ enwere nnukwu palesterol.

Dabere na ọmụmụ, ụmụ nwanyị ndị na-a severalụ ọtụtụ iko biya ma ọ bụ mmanya n'izu, ha nwere ohere dị ukwuu nke ịrịa ọrịa cancer ara.

O buru na inyinya inyinya, ino karie igha olu gi karia ka inwere n’agha. Naanị anwala igosipụta nkwupụta a.

A na-emefu ihe karịrị nde $ 500 kwa afọ na ọgwụ ndị nwere nsogbu nfụkasị naanị na United States. Still kwenyere na a ga-achọpụta ụzọ iji merie allergies n'ikpeazụ?

Ọbara mmadụ "na-agabiga" n'ime arịa ndị nọ n'okpuru nrụgide dị ukwuu, ọ bụrụ na e mebiri iguzosi ike n'ezi ihe ya, ọ nwere ike gbaa 10 mita.

Ndị mmadụ na-eri nri ụtụtụ mgbe niile yikarịrị ka hà buru oke ibu.

Ọrụ mmadụ na-enweghị mmasị na ya bụ ihe na-emebi mmụọ ya karịa enweghị ọrụ ma ọlị.

Afọ mmadụ na-arụ ọrụ dị mma site na iji ihe ndị si mba ọzọ na-enweghị ọgwụ. A maara ihe ọ juiceụastụ na-egbu egbu na-agbaze ọbụna mkpụrụ ego.

E bugara ọtụtụ ọgwụ ka ọ bụrụ ọgwụ. Dịka ọmụmaatụ, azara ahịa Heroin na mbụ ka ọ bụrụ ọgwụ ụkwara. A na-atụkwa ọgwụ cocaine ka ọgwụ na-eme ka ọgwụ na-egbu egbu ma bụrụkwa ụzọ iji nwekwuo ntachi obi.

Dabere na nyocha nke WHO, mkparịta ụka kwa ụbọchị na ekwentị na-eme ka ohere nke ịmalite ụbụrụ dị 40% nwee ohere.

Ọtụtụ nde nje na-amụ, na-ebi ma na-anwụ na anyị gootu. Enwere ike ịhụ ha naanị na nnukwu ịdị elu, ma ọ bụrụ na ha gbakọtara ọnụ, ha ga-adaba na iko kọfị mgbe niile.

E dere temprechọ kachasị elu na Willie Jones (USA), onye nabatara n'ụlọ ọgwụ ahụ na-enwe 46.5 Celsius.

Akụrụ anyị nwere ike sachapụ lita atọ nke ọbara n'otu nkeji.

Nkezi afọ nke lefties erughị righties.

A ma mmanụ azụ azụ kemgbe ọtụtụ iri afọ, n'oge a, egosipụtagoro na ọ na - enyere aka belata mbufụt, belata nkwonkwo mgbu, na - emeziwanye sos.

Ihe onyonyo 3D

Emeputa

Sotex FarmFirma CJSC, 141345, Russia, Moscow Region, Sergiev Posad Municipal District, mmezi ime obodo Bereznyakovskoe, pos. Belikovo, 11.

Tel./fax: (495) 956-29-30.

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