Saroten retard: ntuziaka maka ojiji

Mgbe ị na-ewere okpu a na-akpọ Saroten Retard, a na-atụ aro ị withụ ya na mmiri. Emegheri okpu, agbanyeghi ighe emeghe ma were otutu onu ha mee ha (pellets) site na mmiri. Ekwesighi iji ata.

Ihe omume obi ilu. Ọnọdụ ịda mbà n'obi na schizophrenia. Edere ya otu ugboro n’ụbọchị 3-4 tupu ụra.

Ekwesịrị iji otu capsule 50 mg malite mgbatị ọgwụgwọ na Saroten. Ọ bụrụ na ọ dị mkpa, ka otu izu gasịrị, enwere ike ịbawanye obere ọgwụ kwa ụbọchị ruo capsuo 2 - 3 na mgbede (100-150 mg). Mgbe ị rụzuru akara akara, enwere ike belata ọgwụ kwa ụbọchị ka ọ bụrụ nke kachasị arụ ọrụ, ọ na-abụkarị 1-2 capsules (50-100 mg / ụbọchị).

Mmetụta ọgwụ antidepressant na-etolite mgbe izu 2-4 gachara. Usoro ọgwụgwọ maka ịda mba bụ ihe mgbaàmà, ya mere, a na-atụ aro ka ọ nọgide na-eji ọgwụ antidepressants, gụnyere Saroten Retard, mgbe ọ rụchara nsonaazụ akpọpụtara maka oge zuru ezu ruo - ọnwa 6 iji zere nlọghachi. N'ime ndị ọrịa nwere nsogbu ịlaghachi kwa mgbe (enweghị nke pụrụ iche), enwere ike ịchọ nlekọta ogologo oge nke Saroten Retard, ruo ọtụtụ afọ, na usoro mmezi nke nwere mmetụta nlọghachi nlọghachi.

Ndị okenye (ndị okenye karịrị afọ 65)

Otu capsule 50 mg na mgbede.

Arụ ọrụ akụrụ

Enwere ike ịkọwa Amitriptyline na usoro ọgwụgwọ ọ bụla maka ndị ọrịa nwere ọdịda akụrụngwa.

Nrụsị nke imeju na-ebelata

Ekwesịrị ịkpachara anya mgbe ị na-eji ọgwụ ahụ eme ihe na ndị ọrịa nwere ọrụ imeju, a ga-enyocha nlebara ọbara nke serum amitriptyline oge ọ bụla enwere ike.

Na nkwụsị ọgwụgwọ, a na-atụ aro ka mwepu ọgwụ ahụ ka ejiri nwayọ nwayọ rụọ ọrụ karịa ọtụtụ izu iji zere mmepe nke mmeghachi omume "ndọrọpụ" (lee ngalaba "Mmetụta dị iche iche").

Omume ọgwụ

Amitriptyline bụ ọgwụ mgbochi tricyclic. Amine nke america, amitriptyline, na vivo dika dokwara na - egbochi iweghachi norepinephrine na serotonin na njedebe nke akwara na - ejedebe. Ihe bụ isi metabolite ya, northriptyline, na-egbochi ịlọghachi nke norepinephrine dị obere karịa serotonin. Amitriptyline nwere m-anticholinergic, antihistamine na ọgwụ ndị na-akụjụ ahụ, na-eme ka catecholamines rụọ ọrụ.

Saroten Retard na-eme ka ọnọdụ ahụ nkụda mmụọ dịkwuo mma, ojiji ya kachasị arụ ọrụ na ọgwụgwọ nke nkụda mmụọ na nkụda mmụọ, mana ọ nwekwara ike belata ihe mgbaàmà nke ọgba aghara ndị ọzọ.

N'ihi mmetụta ọgwụgwọ ya, Sarotin Retard dị mma maka ọgwụgwọ nke ịda mbà n'obi site na nchekasị, mkpasu iwe, nchekasị na nsogbu ụra. Dịka iwu, mmetụta antidepressant na - apụta n'ime izu 2-4

Mlọ ọgwụ

N'ihi ntọhapụ nke amitriptyline sitere na capsules nke ihe, plasma ya na-amụba na-ebu ọnụ,

oke ntinye uche a bụ ihe dịka 50% ma e jiri ya tụnyere mbadamba nkume na ntinye ozugbo. Oke itinye uche na plasma ọbara (T_tah) abata n’ime 4 awa.

Bioav wiwa onu: ihe dika 48%. Nortriptyline guzobere n'oge usoro metabolism na-enwekwa ọgwụ antidepressant.

Ogo o doro anya na ekesa bụ ihe dị 14 l / n'arọ. Ogo nke jikọtara na protein plasma bụ ihe dịka 95%.

Amitriptyline na northriptyline na-agafe ihe mgbochi placental.

A na-eme metabolism nke amitriptyline tumadi n'ihi demethylation (isoenzymes CYP2D19, CYP3A) na hydroxylation (isoenzyme CYP2D6), na-esochi conjugation na glucuronic acid. Ihe eji mara metabolism bụ polymorphism mkpụrụ ndụ ihe nketa. Ihe bụ isi metabolite bụ amine nke abụọ - northriptyline. A na - amata metabolites cis- na trans-10-hydroxyamitriptyline na cis- na trans-10-hydroxynortriptyline site na profaịlụ ọrụ yiri ya na northriptyline, ọ bụ ezie na ha anaghị ekwuputa mmetụta ha dị ntakịrị. Demethylnortriptyline na amitriptyline-I-oxide dị na plasma na ebe a na-eleghara anya, metabolite nke ikpeazụ enweghị ọrụ ọrụ ọgwụ. Tụnyere amitriptyline, metabolites niile nwere mmetụta m-anticholinergic na-erughị nke ukwuu.

Ọkara ọkara nke amitriptyline bụ ihe dịka elekere 16 (± 6). Ọkara ọkara nke northriptyline bụ ihe dịka elekere 31 (± 13). Nchịkọta mkpokọta amitriptyline bụ 0.9 l / min.

Ọ na-abụkarị akụkụ akụrụ. N'agbanweghi, ihe dika 2% nke anakporo amitriptyline ka apuru.

Amitriptyline na northriptyline na-apụ apụ na mmiri ara. Ntinye uche na mmiri ara ara na plasma ọbara bụ ihe dịka 1: 1.

Ekwesịrị itinye uche plasma plasma nke amitriptyline na northriptyline na ọtụtụ ndị ọrịa n'ime ụbọchị 7-10. Mgbe ị na-eji capsules ịhapụ oge ogologo na mgbede, ịba amitriptyline na-erute uru kachasị ya na mbubreyo na-ebelata n'ehihie, ebe ịta nri nke northriptyline na-akwụsi ike n'ehihie.

Mkpokọta ọgwụgwọ plasma ọgwụgwọ nke amitriptyline na northriptyline na ọgwụgwọ ịda mba bụ 370-925 nmol / L (100-250 ng / ml). A na - ejikọta mgbakwunye elu karịa 300-400 ng / ml na ohere dịwanye elu nke nsogbu mgbakasị obi yana ndapụta AV mgbochi na mgbasa QRS

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Renrụ ọrụ akụrụma anaghị arụ ọrụ ọgwụ, ọgwụ adịghị ma ọ bụ ọgwụ ọpụrụ aka.

Ndị ọrịa nwere ọria imeju

Ọrụ imeju na - arụ ọrụ nwere ike belata metabolism nke tricyclic antidepressants. .

Data Nchekwa nke ime

Tricyclic antidepressants nwere aru ojoo na-egbu egbu.

Nnyocha mmụba egosipụtara na amamịtị nke amitriptyline nwere n'ụdị nkwụghachi ọnụọgụ nwere obere ala ma e jiri ya wepụta otu amitriptyline nwere wepụta ya ozugbo.

Kemgbe ihe karịrị afọ iri anọ mgbe ejire n’afọ ime, akabeghị nsogbu dị omimi banyere ịmụ nwa.

Ihe ngosi maka ojiji

Ressionda mba n’obi (ọkachasị na nchekasị, nsogbu na nsogbu ịrahụ ụra, gụnyere n’oge nwatakịrị, endogenous, ekwe, mmetụta, akwara, ọgwụ, nwere ọnya ụbụrụ, ị alcoholụ mmanya), psychosis schizophrenic, ọgba aghara mmetụta uche, akparamagwa agwa (omume) na nlebara anya), nocturnal enuresis (belụsọ ndị ọrịa nwere ọnya afọ), bulimia nervosa, ọrịa mgbu na-adịghị ala ala (mgbu na-arịa ndị ọrịa kansa, migraine, ọrịa rheumatic, mgbu na-adịghị efe efe na mpaghara ahụ na ndị mmadụ, postherpetic neuralgia, post-traumatic neuropathy, ọrịa mamịrị ma ọ bụ ọrịa neuropathy na-aga n'ihu), isi ọwụwa, migraine (mgbochi), ọnya afọ na 12 ọnya afọ.

Ihe ngbanwe

Hypersensitivity, jiri ọnụ na MAO inhibitors na izu 2 tupu mmalite nke ọgwụgwọ, myocardial infarction (nnukwu oge na subacute oge), ị alcoholụbiga mmanya oke, ịxụ oké mmanya na ọgwụ ịra ụra, analgesic na psychoactive ọgwụ, glaucoma angle, mmebi siri ike nke AV na intraventricular transction (mgbochi) Gisa, AV block II ogbo), lactation, afọ ụmụaka (rue afọ isii - n'ụkpụrụ ọnụ, rue afọ iri na abụọ na i / m na iv) .C ịkpachara anya. Hohoụ mmanya na-egbu egbu, ụkwara ume ọkụ, akwara mmụọ nke na-akpata nkụja, mgbachi nke ụmị ọkpụkpụ, ọrịa CVD (angina pectoris, arrhythmia, ngọngọ obi, chF, myocardial infarction, ọbara mgbali), ọnya afọ, belata akwara moto na-arụ ọrụ (ihe ize ndụ nke ahụ mkpaghasị akụkụ eriri afọ ime n'ime), , imeju na / ma ọ bụ akụrụngwa akwara, thyrotoxicosis, prostatic hyperplasia, njigide nke urinary, hypotension, schizophrenia (psychosis nwere ike ịrụ ọrụ), warakwụ, ịtụrụ ime (ọkachasị ọnwa atọ), ịka nká.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, na-enweghị ata ata, ozugbo ị risịrị nri (iji belata iwe nke mucosa gastric). Ọgwụ nke mbụ maka ndị okenye bụ 25-50 mg n'abalị, mgbe ahụ, a na-abawanye dose ahụ karịa ụbọchị 5-6 ruo 150-200 mg / ụbọchị na usoro atọ (a na-ewere akụkụ kachasị nke ọgwụ n'abalị). Ọ bụrụ na enweghị mmezi n’ime izu abụọ, a na-abawanye ọgwụ kwa ụbọchị ruo 300 mg. Ọ bụrụ na ihe ịrịba ama nke ịda mbà n’obi na-apụ n'anya, a na-ebelata ọgwụ ahụ ka ọ bụrụ 50-100 mg / ụbọchị ma a na-aga n'ihu usoro ọgwụgwọ ọ dịkarịa ala ọnwa atọ. N’oge agadi, na-enwe nsogbu dị nro, a na-atụ aro ọgwụ nke 30-100 mg / ụbọchị (n’abalị), mgbe ha rutesịrị ọgwụgwọ ahụ, ha na-agbanye na nke kacha nta dị irè - 25-50 mg / ụbọchị.

Intramuscularly ma ọ bụ iv (gbanyere ya nwayọ nwayọ) na dose nke 20-40 mg 4 ugboro kwa ụbọchị, jiri nwayọ dochie ya site na ingestion. Oge ọgwụgwọ agaghị ihe karịrị ọnwa 6-8.

Na nocturnal enuresis na ụmụ 6-10 dị afọ - 10-20 mg / ụbọchị n’abalị, 11-16 afọ - 25-50 mg / ụbọchị.

Asmụaka dị ka ọgwụ mgbochi: site na afọ isii ruo afọ iri na abụọ - 10-30 mg ma ọ bụ 1-5 mg / kg / ụbọchị na-esochi afọ iri na ụma - 10 mg ugboro atọ n'ụbọchị (ọ bụrụ na ọ dị mkpa, ruo 100 mg / ụbọchị).

Maka mgbochi nke migraine, yana mgbu na-adịghị ala ala nke ọdịdị akwara neurogenic (gụnyere isi ọwụwa ogologo oge) - site na 12.5-25 ruo 100 mg / ụbọchị (a na-ewere ọgwụ kachasị n'abalị n'abalị).

Nsonaazụ

Anticholinergic utịp: ọhụhụ ụzọ, akpọnwụ nke ebe obibi, mydriasis, ịba ụba intraocular mgbali (naanị ndị mmadụ nwere ọnọdụ anụ ahụ na - - akụkụ dị warara nke ihu ihu), tachycardia, akpọnwụ akpọnwụ, ọgba aghara, ọgba aghara ma ọ bụ hallucinations, afọ ntachi, ahụ mkpọnwụ nke mgbochi eriri afọ, nsogbu urinating belatara ịchafụ.

Site na sistemụ ụjọ: ụkwara, asthenia, nkụda mmụọ, nchekasị, nchekasị, ihe ndọghachi azụ (ọkachasị na ndị agadi agadi na ndị ọrịa nwere oria Parkinson), nchekasị, mkparị, ụjọ moto, steeti manic, steeti hypomanic, ime ihe ike, ncheta nchekasị, iwepụta echiche , ụba ịda mba, belata ikike itinye uche, ura ụra, nrọ "nrọ abalị", mkpọtụ, asthenia, mmegharị nke mgbanwe nke psychosis, isi ọwụwa, myoclonus, dysarthria, shoor. Igwe mọzụlụ, karịsịa ogwe aka, aka, na isi-ire, elu neuropathy (paresthesia), myasthenia gravis, myoclonus, ataxia, extrapyramidal syndrome, osooso na intensification nke ọdụdọ, Lee agbanwe.

Site na mpaghara CCC: tachycardia, palpitations, dizziness, hyperension orthostatic, mgbanwe ECG na - enweghị isi (etiti oge ma ọ bụ ebili mmiri T) na ndị ọrịa na - enweghị ọrịa obi, arrhythmia, lability ọbara (na-ebelata ma ọ bụ na-amụba ọbara mgbali), nsogbu na-enweghị atụ intraventricular conduction (mgbasawanye nke mgbagwoju anya. QRS, mgbanwe na etiti PQ, ihe mgbochi nke ukwu nke ukwu nke Ya).

Site na usoro nri: ọgbụgbọ, ọrịa ịba ọcha n'anya (gụnyere ọrụ imeju na cholestatic jaundice), obi mgbu, vomiting, gastralgia, agụụ na ụba na ahuhu ma ọ bụ belata afọ na ahụ, stomatitis, mgbanwe uto, afọ ọsịsa, ire nke ọchịchịrị.

Site na usoro endocrine: mmụba na nha (edema) nke testicles, gynecomastia, mmụba na nha nke mammary glands, galactorrhea, mbelata ma ọ bụ mmụba nke libido, mbelata ikike, hypo- ma ọ bụ hyperglycemia, hyponatremia (mbelata nke mmepụta vasopressin), na ọrịa nke adịghị mma.

Site na akụkụ ahụ na hemopoietic: agranulocytosis, leukopenia, thrombocytopenia, purpura, eosinophilia.

Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ, itching nke anụ ahụ, urticaria, onyonyo afọ, ọzịza nke ihu na ire.

Ihe ozo: ntutu isi, tinnitus, edema, hyperpyrexia, lymph nodes swollen, njide nke urinary, pollakiuria, hypoproteinemia.

Mwepu mgbapu: na mwepu mberede mgbe ejigidechara ọgwụgwọ - ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, isi ọwụwa, ịba, nsogbu ịrahụ ụra, nrọ na-adịghị ahụkebe, na-eji nwayọ nwayọ, na iwepụ nwayọọ nwayọọ mgbe ọ gbachara ọgwụgwọ - mgbakasị ahụ, nchekasị ụgbọala, ọgba aghara ụra, nrọ na-enweghị atụ.

E guzobebeghị njikọ ya na nchịkwa ọgwụ: lupus-like syndrome (ọrịa ogbu na nkwonkwo, ọdịdị nke mgbochi antinuclear na ezigbo rheumatoid factor), ọrụ imeju na-arụ ọrụ, afọ ndụ.

Mmeghachi omume mpaghara maka nchịkwa iv: thrombophlebitis, lymphangitis, na-enwu ọkụ, mmeghachi ahụ nfụkasị anụ ahụ. Ọrịa Site n'akụkụ akụkụ akwara dị iche iche: iro ụra, nzuzu, coma, ataxia, hallucinations, ụjọ, ụjọ psychomotor, belata ike itinye uche, mkpofu, ọgba aghara, dysarthria, hyperreflexia, isi ike, choreoathetosis, ọrịa akwụkwụ.

Site na CCC: mbelata ọbara mgbali, tachycardia, arrhythmia, intracardiac conduction, mgbanwe ECG (ọkachasị QRS), ujo, nkụchi obi, njirimara nke egbu egbu tricyclic antidepressant, ujo, nkụda obi obi n'ọnọdụ ndị ọ na-adịghị ahụkebe.

Ndị ọzọ: ịda mba iku ume, mkpụmkpụ nke iku ume, cyanosis, vomiting, hyperthermia, mydriasis, sweating mụbara, oliguria or anuria.

Mgbaàmà na-etolite 4 awa mgbe ịdoụbiga ya ókè, rute oke mgbe awa 24 gachara ụbọchị anọ gara aga. Ọ bụrụ na a na-enyo nfefere oke, ọkachasị ụmụaka, onye ọrịa kwesịrị ịga ụlọ ọgwụ.

Ọgwụ: site na nchịkwa ọnụ: nchịkwa eriri afọ, nchịkwa nke unyi na-arụ ọrụ, usoro ọgwụgwọ na usoro nkwado, na-enwe mmetụta anticholinergic siri ike (mbelata ọbara mgbali, arrhythmias, coma, myoclonic seizures) - nchịkwa nke cholinesterase inhibitors (a naghị atụ aro physostigmine n'ihi ohere dị ukwuu nke ọdụdọ. ), ịnọgide na-enwe ọbara mgbali na nguzo mmiri-electrolyte. E gosipụtara njikwa nke ọrụ CCC (gụnyere ECG) maka ụbọchị 5 (nlọghachi nwere ike ime mgbe awa 48 gasịrị ma ọ bụ mgbe e mesịrị), ọgwụgwọ anticonvulsant, ikuku ikuku, na usoro nhachi ọzọ. Ọrịa akụrụngwa na akwara dialsis anaghị arụ ọrụ.

Ntụziaka pụrụ iche

Tupu ịmalite ọgwụgwọ, ọ dị mkpa ịchịkwa ọbara mgbali (na ndị ọrịa nwere ọbara mgbali elu ma ọ bụ labile ọ nwere ike ibelata ọbụna), n'oge usoro ọgwụgwọ ọ dị mkpa iji chịkwaa ọbara na mpaghara (n'ọnọdụ ụfọdụ, agranulocytosis nwere ike ịmalite, ya mere a na-atụ aro ka ị nyochaa foto ọbara, karịsịa mụbara ahụ ọkụ, mmepe nke ụdị ihe mgbaàmà na ọnya mgbu), na usoro ọgwụgwọ ogologo oge - njikwa ọrụ nke CVS na imeju. N'ime ndị agadi na ndị ọrịa nwere ọrịa CCC, njikwa ọnụego obi, ọbara mgbali elu, egosi ECG. Mgbanwe ndị na-enweghị isi na-esite na ECG nwere ike ịdakwasị ECG (smoothing of the T wave, ndagide nke S-T, mgbasawanye nke QRS complex).

Iji Parenteral mee ihe ga-ekwe omume naanị n'ụlọ ọgwụ, n'okpuru nlekọta nke dọkịta, yana izu ike n'ụbọchị mbụ nke ọgwụgwọ.

Achọrọ ịkpachara anya mgbe na-enweghị ike ịkwaga na ọnọdụ kwụ ọtọ site na ọnọdụ ụgha ma ọ bụ ọdụ.

N'oge ọgwụgwọ, ekwesịrị ịhapụ ethanol.

Nyefee ihe na-erughị ụbọchị iri na anọ ka ịlaghachite ndị na - egbochi MAO, na - amalite site na obere usoro.

Site na ịkwụsị nchịkwa na mberede mgbe ọgwụgwọ ogologo oge, mmepe nke ọrịa "ndọrọpụ" enwere ike.

Amitriptyline na usoro onyonyo dị elu karịa 150 mg / ụbọchị na-ebelata ọnụ ụzọ nke ihe ịma mma (ihe egwu nke ọdịdọ nke ndị ọrịa a na-atụ anya ya, yana ọnụnọ nke ndị ọzọ, kwesịrị ịtụle)ihe ndị na-eme ka ihe na-eme n’ọrịa nkwarụ bụ ọmụmaatụ, mmerụ ụbụrụ nke etiology ọ bụla, ojiji nke ọgwụ antipsychotic (antipsychotic) n’otu oge jụrụ ethanol ma ọ bụ iwepu ọgwụ ndị nwere akụrụngwa anticonvulsant, dị ka benzodiazepines).

Ihe eji amata oke nsogbu nke igbu onwe ya, nke nwere ike idigide rue mgbe nwetere mgbaghara dị mkpa. N'akụkụ a, na mmalite ọgwụgwọ, enwere ike igosipụta nchikota ya na ọgwụ sitere na benzodiazepine ma ọ bụ ọgwụ antipsychotic na nlekọta ahụike mgbe niile (na-agwa ndị ọrụ tụkwasịrị obi ịchekwa ma nye ọgwụ).

N'ime ndị ọrịa nwere nsogbu ọgbụgba cyclic n'oge nkụda mmụọ, usoro ọgwụgwọ nwere ike ịmalite ọnọdụ manic ma ọ bụ hypomanic (ọ dị mkpa iji belata ọgwụ ahụ ma ọ bụ kagbuo ọgwụ ahụ ma depụta ọgwụ antipsychotic). Mgbe ịkwụsị ọnọdụ ndị a, ọ bụrụ na enwere ihe ngosi, enwere ike ịmaliteghachi ọgwụgwọ na obere doses.

N'ihi mmetụta ọrịa obi nwere ike ịdị, achọrọ ịkpachara anya mgbe ị na-agwọ ndị ọrịa nwere thyrotoxicosis ma ọ bụ ndị ọrịa na-anata usoro homonụ thyroid.

Na mgbakwunye na usoro elektrokovulsive, a na-enye ya ọgwụ naanị nlezianya na-ahụ maka nlekọta ahụike.

N'ime ndị ọrịa a na-atụ anya ya na ndị ọrịa meworo agadi, ọ nwere ike ịkpasu mmepe nke psychoses ọgwụ, tumadi n'abalị (mgbe ịkwụsị ọgwụ ahụ, ha na-apụ n'anya n'ime ụbọchị ole na ole).

O nwere ike ibute ihe mgbochi afọ na-eme mkpagharị, ọkachasị n’etiti ndị ọrịa nwere ọrịa afọ mgbu, ndị agadi ma ọ bụ ndị ọrịa a manyere idebe izu ike.

Tupu ịme anesthesia izugbe ma ọ bụ mpaghara, ekwesịrị ịdọ aka ná ntị na onye ọrịa na-ewere amitriptyline.

N'ihi ihe anticholinergic, mbelata nke lacrimation na mmụba nke ọnụ nke imi mmiri ga-ekwe omume, nke nwere ike ibute mmebi nke epithelium corneal na ndị ọrịa na-eji lenses kọntaktị.

Site na iji ogologo oge, a na-abawanye na ihe omume nke ezé caries hụrụ. Enwere ike ịbawanye mkpa maka riboflavin.

Ọmụmụ banyere omumu nke ụmụ anụmanụ kpughere mmetụta dị njọ na nwa ebu n’afọ, na enwebeghị ọmụmụ ihe zuru oke ma na-achịkwa nke ọma n’ime ụmụ nwanyị dị ime. N'ime ụmụ nwanyị dị ime, ekwesịrị iji ọgwụ ahụ mee ihe ma ọ bụrụ na ebumnuche ebumnuche ya na nne ya karịrị ihe ize ndụ nke nwa ebu n'afọ.

Ọ bara n’ime mmiri ara ara nwere ike bute ụra n’etiti ụmụ ọhụrụ.

Iji zere mmepe nke ọrịa "ndọrọpụ" na ụmụ amụrụ ọhụrụ (emere ka ọ pụta ìhè na mkpụmkpụ ume, nkụda mmụọ, eriri afọ, mgbakasị ahụ erughị ala, hypotension ma ọ bụ ọbara mgbali, oke ma ọ bụ spastic phenomena), a ga-eji nwayọọ nwayọọ kagbuo amitriptyline opekata mpe izu asaa tupu amụọ nwa.

Aremụaka na-ahụkarị maka oke ị toụ oke, nke ekwesiri ilebara anya dị ize ndụ ma nwee ike igbu ha.

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Mmekorita

Site na iji ethanol na ọgwụ jikọtara ọnụ nke na-akụda sistemụ akwara etiti (gụnyere ọgwụ antidepressants ndị ọzọ, barbiturates, benzadiazepines na ọgwụ na-akụnwụ ahụ), mmụba dị ukwuu na mmetụta inhibitory na sistemụ akwara Central, nkụda mmụọ na mmetụta hypotensive ga-ekwe omume.

Ọ na - eme ka mmadụ nwe uche n'ihe ọ toụ containingụ nwere ethanol.

Na-eme ka mmetụta anticholinergic nke ọgwụ ọjọọ na-arụ ọrụ anticholinergic (dịka ọmụmaatụ, phenothiazines, ọgwụ antiparkinsonian, amantadine, atropine, biperidene, antihistamines), nke na-abawanye ohere nke nsonaazụ ndị ọzọ (site na sistemụ akwara etiti, ọhụụ, eriri afọ na eriri afọ).

Mgbe ejikọtara ya na antihistamines, clonidine, mmụba na mmetụta inhibitory na sistemụ akwara, yana atropine, na-abawanye ihe ize ndụ nke ihe mgbochi ụbụrụ, yana ọgwụ ndị na-akpata mmeghachi omume extrapyramidal na-abawanye ogo na ugboro nke mmetụta extrapyramidal.

Site n'otu oge iji amitriptyline na anticoagulants na-apụtaghị ìhè (ọgwụ coumarin ma ọ bụ indadione), mmụba na ọrụ anticoagulant nke ikpeazụ ga-ekwe omume.

Amitriptyline nwere ike ịba ụba ịda mba nke corticosteroids kpatara.

Mgbe ejikọtara ya na ọgwụ anticonvulsant, ọ ga - ekwe omume ịbawanye mmetụta mgbochi na sistemụ na - etiti, belata ọnụ ụzọ maka ọrụ nkwarụ (mgbe eji ya na oke doses) ma belata arụmọrụ nke ikpeazụ.

Ọgwụ maka ọgwụgwọ nke thyrotoxicosis na-abawanye ihe ize ndụ nke agranulocytosis.

Na-ebelata ịdị irè nke phenytoin na alfa-blockers.

Ndị na - egbochi microidal oxidation (cimetidine) na - agbatị T1 / 2, mụbaa ihe egwu nke amitriptyline (enwere ike ịbelata dose 20-30%), ndị na - enzymes microsomal (barbiturates, carbamazepine, phenytoin, nicotine na ọgwụ mgbochi). belata arụmọrụ nke amitriptyline.

Fluoxetine na fluvoxamine na-abawanye itinye uche nke amitriptyline na plasma (enwere ike ịbelata mbelata nke amitriptyline site na 50%).

Mgbe ejikọtara ya na anticholinergics, phenothiazines na benzodiazepines - njikọta nke nkwonkwo mgbochi na etiti anticholinergic na ịba ụba nke ihe ọdịdọ (wedata ọnụ ụzọ ọrụ ọdịdọ), phenothiazines, na mgbakwunye, nwere ike ịbawanye ihe ize ndụ nke neuroleptic malignant syndrome.

N'iji oge nke amitriptyline na clonidine, guanethidine, betanidine, reserpine na methyldopa - mbelata mmetụta hypotensive nke ikpeazụ, ya na cocaine - ihe ọghọm nke arrhythmias obi.

Ọgwụ ogwu na-egbochi ọgwụ mgbochi estrogen na estrogens nwere ike ịbawanye ndu nke amitriptyline, ọgwụ antiarrhythmic (dị ka quinidine) na-abawanye ohere nke ọgba aghara (ikekwe na-ebelata metabolism nke amitriptyline).

Iji nkwonkwo mee ya na disulfiram na ndị ọzọ na-egbochi acetaldehydrogenase na-akpalite nkụda mmụọ.

Ekwekorita nke MAO inhibitors (mmụba enwere ike na oge nke hyperpyrexia, nkwarụ siri ike, ọgba aghara ọbara na ọnwụ onye ọrịa).

Pimozide na probucol nwere ike ịmụba arrhythmias obi, nke gosipụtara n'ịgbatị oge etiti oge Q-T na ECG.

Ọ na - akwalite nsonaazụ na epilephrine, norepinephrine, isoprenaline, ephedrine na phenylephrine na CVS (gụnyere mgbe ọgwụ ndị a bụ akụkụ nke mgbatị mpaghara) yana ịbawanye n'ihe ize ndụ nke ọgba aghara obi, tachycardia, na ọbara mgbali elu.

Mgbe ejikọtara ya na alfa-adrenostimulants maka nchịkwa intranasal ma ọ bụ maka iji rụọ ọrụ ophthalmology (na ntinye usoro dị ukwuu), vasoconstrictor nke ikpeazụ ahụ nwere ike ịba ụba.

Mgbe ejikọtara ya na homonụ thyroid - nkwalite nkwonkwo nke ọgwụgwọ ọgwụgwọ na nsonaazụ nsị (gụnyere cardiac arrhythmias na mmetụta na-akpali akpali na sistemụ akwara Central).

M-anticholinergics na ọgwụ antipsychotic (antipsychotics) na-abawanye ihe ize ndụ nke hyperpyrexia (karịsịa na ihu igwe na-ekpo ọkụ).

Site na oge njikọta na ọgwụ ọgwụ hematotoxic ndị ọzọ, mmụba nke hematotoxicity ga-ekwe omume.

Saroten Retard (Saroten Retard) - ụdị ntọhapụ, ihe mejupụtara na nkwakọ

Capsules nke ogologo oge bụ gelatin siri ike, nha nke 2, opaque, nwere ahụ ya na mkpuchi nke agba agba na-acha ọbara ọbara, ọdịnaya nke capsules bụ pellets site na ọ fọrọ nke nta ka ọ na-acha ọcha ruo odo.

Okpu 1. amitriptyline hydrochloride 56.55 mg, nke kwekọrọ na ọdịnaya nke amitriptyline 50 mg.

Ndị ọkachamara: mkpụrụ ọka (shuga dị na shuga), stearic acid, shellac (shellac na-emeghị eme), talc, povidone.

Ihe mejupụtara shei capsule: gelatin, iron dye oxide red (E172), titanium dioxide (E171).

Saroten Retard (Saroten Retard) - ọgwụ ọgwụ

Ọnụọgụ bioavailability nke amitriptyline bụ ihe dịka 60%. Ijikọ protein protein Plasma bụ ihe dịka 95%. Ntinye uche nke amitriptyline n’ime ọbara ọbara ji nwayọ nwayọ karịa mgbe ị na-ewere Saroten na mbadamba, mgbe elekere 4-10 gachara, emesịa, ọ ka kwụsiri ike ogologo oge.

Na usoro onunu ogwu, oke uru nke ị theụ ọgwụ na plasma dị ala mgbe ị na-ewere okpu, nke a na-esonyere na nsonaazụ obi ala nke Saroten Retard.

A na-eme metabolism nke Amitriptyline site na demethylation na hydroxylation. A na-ewere Nortriptyline bụ isi metabolite nke amitriptyline. T1 / 2 nke amitriptyline averages 25 awa (awa 16-40), T1 / 2 nke nortriptyline - ihe dị ka awa 27. E guzobere Css mgbe izu 1-2 gachara. Amitriptyline bụ ọkachasị na mmamịrị na, akụkụ ya ụfọdụ, na feces. Amitriptyline na northriptyline gafere ihe mgbochi placental na obere ego na-apụ apụ na mmiri ara.

Ihe ngosi maka iji ogwu

Obi nkoropụ, ọkachasị na nchekasị, oke iwe, na nsogbu ọgba aghara:

• ọgwụgwọ nke nkụda mmụọ nke ụdị monopo- na nke ihe imerụ ahụ, ntinyeghị aka, masked na depression menopausal,
• dysphoria na ị depressionụbiga mmanya ókè,
• mmeghachi omume ịda mba
• ịda mba neurosis
• ọgwụgwọ ịda mbà n'obi nke schizophrenic (yana ọgwụ ịba ọcha),
• ọrịa mgbu na-adịghị ala ala.

Saroten Retard (Saroten Retard) - usoro onunu ogwu

Mgbe ị na-ewere okpu a na-akpọ Saroten Retard, a na-atụ aro ị withụ ya na mmiri. Emegheri okpu, agbanyeghi, apuru imeghe ma buru ihe edere n’ime ya (otutu umu aka) site na mmiri. A machibidoro ụmụ oke ihe na-ata ata.

Maka ọgwụgwọ nke ịda mba, a na-edenye ya oge 1 / awa 3-4 tupu oge ịrahụ na doses dabara na 2/3 nke usoro nke Saroten na mbadamba.

Ndị okenye kwesịrị ịmalite iji Saroten Retard jiri otu capsule 50 mg na mgbede. Ọ bụrụ na ọ dị mkpa, mgbe izu 1-2 gasịrị, enwere ike ịbawanye usoro ị ga-eme kwa ụbọchị gaa na capsules 2-3 na mgbede (100-150 mg). Mgbe ị rụzuru akara ejiri akara, enwere ike ịbelata usoro ị ga-eme kwa ụbọchị ka ọ dịkarịa ala na-arụ ọrụ nke ọma, ọtụtụ mgbe ruo 1-2 capsules (50-100 mg /). Na ọgwụgwọ nke ịda mba, a na-atụ aro ka ọ nọgide na-eji ọgwụ mgbochi, gụnyere Saroten Retard, mgbe ọ nwesịrị nsonaazụ akpọ akpọ maka ọnwa 4-6 ọzọ. Na usoro mmezi nke nwere mmetụta ịlaghachi azụ, enwere ike iwere Saroten Retard ogologo oge, ruo ọtụtụ afọ.

Ndị agadi kwesịrị ịmalite iji Saroten gwọọ ya na mbadamba - 30 mg / (3 ruo 10 mg). N'ime ụbọchị ole na ole, ọ ga-ekwe omume ịgbanwee gaa na ị nweta capsule Saroten Retard. Usoro ubochi kwa ubochi bu 1-2 capsules (50-100 mg), ewere ya na mgbede.

Na nkwarụ mgbu na-adịghị ala ala maka ndị okenye, usoro ọgwụ kwa ụbọchị bụ 1-2 capsules (50-100 mg), weere na mgbede. O kwere omume ibido ọgwụgwọ were were Saroten na mbadamba 25 mg otu mgbede.

Mmetụta ndị metụtara nsonaazụ anticholinergic: nkụ na / ma ọ bụ uto ilu n'ọnụ, ọgbụgbọ, vomiting, stomatitis, adịkarịghị - cholestatic jaundice, ọhụhụ dị nro, ụba intraocular pressure, tachycardia, afọ ntachi, ọtụtụ mgbe - njide urinary. Ha na-egosipụtakarị na mmalite ọgwụgwọ, mgbe ahụ, ọkachasị, belata.

• Site n'akụkụ nke usoro akwara obi: tachycardia, arrhythmias, orthostatic hypotension, intracardiac traction, na-edekọ naanị na ECG, mana ọ bụghị n’ihu pụtara ìhè.
• Site n'akụkụ nke usoro ụjọ ahụ: ụra, adịghị ike, ntinye uche, isi ọwụwa, nkụda mmụọ. Mgbakasị ndị a, nke na-eme na mmalite nke usoro amitriptyline, na-ebelata n'oge ọgwụgwọ. Ọ na-adịkarịghị, ọkachasị mgbe ejiri usoro ọgwụgwọ mbụ dị elu, nhụsianya, ọgba aghara, ọgba aghara, mkparị, hallucinations, nsogbu extrapyramidal, ịma jijiji na nhụsianya nwere ike ịdapụta, enweghị oge ụjọ.

Mmeghachi omume nfụkasị: ọnya anụ ahụ, itching ga-ekwe omume.

Ndị ọzọ: ọgbụgbọ, ịsụsọ, ibu ibu, belata libido nwere ike ime.

Ihe ngbanwe

• myocardial infarction na-adịbeghị anya,
• Ọgba aghara gbasara ọrịa obi
• nsi ojoo site na mmanya, barbiturates ma ọ bụ opiates,
• mmechi mmechi
• jiri MAO inhibitors na izu abụọ gbasaa.
• hypersensitivity na amitriptyline.

Saroten Retard - Ntuziaka Pụrụ Iche

Ekwesịrị iji Saroten Retard jiri nlezianya mee ihe na ndị ọrịa nwere nkwarụ, njide urinary, hyperrophy prostate, imeju siri ike ma ọ bụ ọrịa obi, yana hyperthyroidism.

Inwe mmetụta ịgwọ ọrịa, ọ nwere ike imetụta ikike ịchịkwa ụgbọ ala na usoro ndị ọzọ. Ekwesịrị ka dọkịta dụọ ndị ọrịa na-a Saụ Saroten Retard ụzọ maka akụkụ a nke ọgwụ ahụ.

Saroten Retard - Nwepu

Ọrịa Mmegide ma ọ bụ nsogbu nke usoro ụjọ ahụ. Ngosiputa ojoo nke anticholinergic (tachycardia, membranes mucous akọrọ, njide nke urinary) na cardiotoxic (arrhythmias, hypotension art የደም, obi ida). Ọrịa aghara aghara. Ọbara.

Ọgwụgwọ. Na-atụle Symptomatic. A ga-eburịrị ya ụlọ ọgwụ. Site na nchịkwa ọnụ nke amitriptyline, ekwesịrị ịrụ ọrụ gastric ngwa ngwa o kwere mee ma ekwukwa na icheku unyi na-arụ ọrụ. Ekwesịrị ime ihe iji dozie akụkụ iku ume yana usoro akwara. Nyochaa ọrụ gbasara obi n'ime ụbọchị 3-5 dị mma. Edereghi epinephrine (adrenaline) n'akwụkwọ n'ọnọdụ ndị a. Maka nsogbu ọrịa aghara, enwere ike iji diazepam mee ihe.

Saroten Retard (Saroten Retard) - njikọta ọgwụ

Amitriptyline nwere ike ịkwalite nsonaazụ ethanol, barbiturates na ihe ndị ọzọ na-ewute sistemụ akwara etiti.

Iji otu olu na MAO inhibitors nwere ike ibute nsogbu ọgbụgba.

Ebe ọ bụ na amitriptyline na-eme ka nsonaazụ anticholinergics pụta, a ga-ezere nchịkwa oge na ha.

Ọ na-eme ka mmetụta nke sympathomimetics nke epinephrine (adrenaline), norepinephrine (norepinephrine) rụpụta, n'ihi nke a, ọgwụ ndị na-agwọ ọrịa mpaghara nwere ihe ndị a ekwesịghị iji otu oge na amitriptyline.

Enwere ike ibelata mmetụta antihypertensive nke clonidine, betanidine, na guanethidine.

Mgbe edekọtara ya na ọgwụ mgbochi, ekwesịrị iburu n'uche na ọgwụ mgbochi tricyclic na antipsychotics na-egbochi metabolism nke ibe ha, na-agbadata ọnụ ụzọ maka ịdị njikere ike mmụọ.

N'iji oge eme ihe na cimetidine, mbelata metabolism nke amitriptyline, mmụba na ntinye ya na plasma ọbara na mmepe nke mmetụta na-egbu egbu.