Kedu ihe dị iche na Finlepsin na Finlepsin Retard? Finlepsin retard: ntuziaka maka ojiji

Federal Center maka Neurosurgery

Mepụta Ozi Ọhụụ.

Mana ị bụ onye ọrụ na-enweghị ikike.

Ọ bụrụ n ’edebanye aha na mbido, wee banye“ nbanye ”(ụdị nbanye ya n’elu akụkụ aka nri nke saịtị ahụ). Ọ bụrụ na nke a bụ oge izizi ebe a, debanye aha.

Ọ bụrụ n ’idebanye aha gị, ị ga-enwe ike soro azịza ozi gị n'ọdịnihu, gaa n'ihu na mkparịta ụka na isiokwu ndị na-atọ ụtọ n'etiti ndị ọrụ ndị ọzọ. Na mgbakwunye, ndebanye aha ga - enyere gị aka ịme nnabata nkeonwe gị na ndị ndụmọdụ na ndị ọrụ ndị ọzọ nke saịtị ahụ.

Usoro onunu ogwu na nhazi

100 mg na mgbede 100 mg na mgbede
Ulo mmezi nke 200-600 mg kwa ubochi ututu 400-600 mg na mgbede
200 mg n'ụtụtụ 200-400 mg na mgbede 200-400 mg n'ụtụtụ 400-600 mg na mgbede

Ogo usoro a gosipụtara na tebụl ekwesịghị gafere.
Ọgwụ n'ụlọ mmanya.
Nkezi nha kwa ụbọchị kwekọrọ na 600 mg nke carbamazepine (200 mg n'ụtụtụ na 400 mg na mgbede).
Ewoo
N'okwu ndị siri ike, na ụbọchị mbụ, enwere ike ịbawanye ọgwụ ahụ ruo 1200 mg nke carbamazepine kwa ụbọchị, nke kewara abụọ. Agaghị ejikọta Finlepsin retard na ọgwụ ogwugwo. Ọ bụrụ na ọ dị mkpa, enwere ike ijikọ retardpsin retardps na ihe ndị ọzọ eji eme ihe maka ị withdrawalụ mmanya. N'oge ọgwụgwọ, ọ dị mkpa iji nlezianya nyochaa ọdịnaya nke carbamazepine na plasma ọbara. Na njikọ mmepe nke mmetụta ndị sitere na sistemụ akwara na akwara autonomic, a na-elezi ndị ọrịa anya n'ụlọ ọgwụ.
Trigeminal neuralgia, iriopathic neuropathy nke akwara glossopharyngeal.
Ọgwụ nke mbụ bụ 200-400 mg nke carbamazepine kwa ụbọchị, nke kewara abụọ. A na-abawanye ọgwụ mbụ ruo mgbe ihe mgbu na-apụ n'anya kpamkpam, na nkezi ruo 400-800 mg nke carbamazepine kwa ụbọchị. Mgbe nke ahụ gasị, n'otu akụkụ nke ndị ọrịa, enwere ike ịga n'ihu na ọgwụgwọ nlekọta dị ala nke 400 mg nke carbamazepine.
Edere Finlepsin retard na ndị ọrịa agadi na ndị ọrịa nwere karabamazepine na mbido mbụ nke 100 mg carbamazepine (1/2 mbadamba 200 mg) ugboro 2 n'ụbọchị.
Mgbu na neuropathy mamịrị.
Ihe nkezi kwa ụbọchị bụ 200 mg n'ụtụtụ na 400 mg nke carbamazepine na mgbede. N'ọnọdụ ndị pụrụ iche, enwere ike ịkọpụta Finlepsin retard na dose 600 mg nke carbamazepine ugboro abụọ n'ụbọchị. Akwụkwụ na-adọ adọ n'ime otutu sclerosis.
Ewoo
Ọkara a na-eme kwa ụbọchị bụ 400 - 800 mg nke carbamazepine, nke kewara abụọ.
Ọgwụgwọ na mgbochi nke psychosis
Usoro ọgwụgwọ mbụ, nke na-ekwekọkarị na usoro mmezi, bụ 200-400 mg nke carbamazepine kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ a ruo 800 mg nke carbamazepine kwa ụbọchị, nke kewara abụọ.
Ogologo oge eji na-adabere na ngosipụta na nzaghachi nke onye ọrịa na ọgwụ ahụ. Akwụkwụkwụ na-agwọ ọrịa ogologo oge. Ọkacha mara ọkachamara kwesịrị ikpebi n’itinye onye ọrịa na Finlepsin retard, oge oji ya na kagbuo ya n’otu n’otu. Ọgwụ nke ọgwụ ahụ nwere ike belata ma ọ bụ kwụsị kpam kpam ọgwụgwọ ọ bụghị tupu mgbe afọ 2-3 nke enweghị ọdịdọ.
A na-akwụsị ọgwụgwọ site na mbelata nke ị theụ ọgwụ ahụ ruo afọ 1-2. N'okwu a, ụmụaka kwesịrị iburu n'uche mmụba nke anụ ahụ. Ihe ngosi electroencephalogram ekwesighi ibelata.
Na ọgwụgwọ nke neuralgia, ọ bụ ihe amamihe dị na ya ịkọpụta retlepsin retard na ọgwụ zuru oke iji belata ihe mgbu, ruo ọtụtụ izu. Site na iwetulata ọgwụ a, ọ dị mkpa ịchọpụta ma enwere ike ịlaghachite ọrịa. Site na ịmaliteghachi ihe mgbu, a na-eji usoro ọgwụgwọ na-aga n'ihu iji ọgwụgwọ.
Ogologo oge ọgwụgwọ maka mgbu na neuropathy mamịrị na ọrịa ọdịdọ na otutu sclerosis bụ otu ihe ahụ maka neuralgia.
A kwụsịrị ọgwụgwọ Finlepsin nke ọrịa ị withdrawalụbiga mmanya na-abawanye site na iji nwayọ nwayọ were ihe dị ka ụbọchị 7-10.

Nchedo nchekwa

Finlepsin Retard - ọgwụ maka ọgwụgwọ nke dibiazepine usoro Akwụkwụ na-adọ. O nwere antidepressant, antipsychotic, vasopressin-like action. N'ime ndị nwere nsogbu akwara dị n'akụkụ, nke ihe mgbu na-egosipụta na mpaghara azụ nke akwara, ọ na-egosipụta nsonaazụ. Mmetụta ọgwụ na-akpata bụ n'ihi ebugharị nke ụzọ sodium voltaji, n'ihi nsonaazụ nke neurons na-emebiga ihe ókè, a na-eme ka ọgbọ nke ọtụtụ usoro nke neurons na mmechi ọrịre na synapses. Ọ na - egbochi glutamate, amino acid nke nwere ọrụ neurotransmitter, ịbanye na etiti intercellular, ma na - ebute ụzọ n ’ụbụrụ ụdọ ahụ, si otú a na - arụ ọrụ antiepileptik. Ọ na - akwalite ụgbọ njem ndị ọzọ na - arụ ọrụ ike. N’ebe ndị mmadụ na-arịa ọrịa akwụkwụ (ọkachasị maka ụmụaka na ndị na-eto eto), ọgwụ a na-ebelata nchekasị, ogo nke ngosipụta ịda mba, oke iwe na-ebelata, na oke iwe na-apụ n'anya. A na-ekpebi nsonaazụ nke ọrụ cognitive na njirimara psychomotor site na iji ọgwụ a .ụrụ. Mmetụta anticonvulsant na-amalite ịpụta na nha site na awa 3-4 ruo ọtụtụ ụbọchị (n'ọnọdụ ụfọdụ - ruo ụbọchị 30). Ọrịa ọgbụgbọ, ọ na-eme ka ọnụ ụzọ ụdọ ahụ dị, belata ya site na mmanya, na-ebelata akara ngosipụta (ọ na-eme ka a kwụsị ịtụ ụjọ, ịma jijiji na mkpịsị aka mkpịsị aka, na-eme ka ihe ghara ịdị mma).

Mmetụta antipsychotic na-apụta mgbe ụbọchị 7-10 gasịrị. Longdị ogologo ọgwụ dị otú a nwere ike jikọta ya na nrụgide nke dopamine na metabolism nke norepinephrine. Finlepsin Retard bụ ụdị usoro onunu ogwu na-arụ ọrụ nke na-enye nguzosi ike nke ihe na-arụ ọrụ na plasma n'ọtụtụ njikwa 1-2 ugboro n'ụbọchị. Site na nchịkwa ọnụ nke ọgwụ ahụ, ọgwụ ahụ ji nwayọ nwayọ ma etinye uche ya na eriri afọ (ọnụnọ nke ihe oriri dị na eriri afọ anaghị enwe mmetụta akpọsara na ọsọ na izuzu nke ihe). A na-ahụkarị mkpokọta akụkụ ahụ dị ike n'ime ọbara ka awa iri anọ na abụọ gachara. Nkera ọkara ndụ ha dịka 70 awa. Iwepu ahụ mmadụ na-ebu akụrụ ya na oke obere, site na eriri afọ. Oge kachasị mma iri nri bụ ma ọ bụ ozugbo nri. A na-ahapụ ya ka iwepu mbadamba mbadamba ma ọ bụ akụkụ ya na mmiri tupu nchịkwa: oge ​​nke ọgwụ adịghị ata ahụhụ site na nke a. Otutu maka ntinye - 1-2 ugboro n'ụbọchị. Ọgwụ a na-amalite site na obere obere ụbọchị kwa ụbọchị yana mmụba dị ole na ya ruo mgbe a ga-enweta azịza ọgwụgwọ.

Ọgwụ Farmacology

Ọgwụ antiepileptic sitere na iminostilbene tricyclic. Ekwenyere na mmetụta anticonvulsant metụtara na mbelata ikike nke neurons iji nọgide na-enwe nnukwu ike nke ike ime ihe ugboro ugboro site na inac ọwa nke sodium. Na mgbakwunye, mgbochi nke ntọhapụ neurotransmitter site na igbochi ọwa mmiri sodium na mmepe nke ike ime ihe, nke n'aka nke ahụ na-ebelata mbufe synaptik, ọ dị ka ọ dị mkpa.

O nwere antimaniacal dị ala, mmetụta antipsychotic, yana mmetụta analgesic maka mgbu neurogenic. Ndị na-anabata GABA, nke nwere ike jikọtara ya na ọwa kalsel, nwere ike itinye aka na usoro nke ime ihe, mmetụta nke carbamazepine na sistemu modttor neurotransmitter dịkwa ka ọ dị oke mkpa.

Enwere ike ijikọ mmetụta antidiuretic nke carbamazepine na hypothalamic mmetụta na osmoreceptors, nke na-agbagha site na nzuzo nke ADH, ọ bụkwa n'ihi nsonaazụ na tubules renal.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, carbamazepine fọrọ nke nta ka ọ banye kpamkpam na ngọngọ nri. Indmịnye protein ndị dị na plasma bụ 75%. Ọ bụ onye na - eme enzymes imeju ma na - akpali metabolism nke ya.

T 1/2 bụ awa 12-29. 70% ka ọ na-apụta na mmamịrị (n'ụdị nke metabolites na-adịghị arụ ọrụ) yana 30% na feces.

Mpempe mwepụta

Mbadamba ụrụ dị ogologo oge site na ọcha ruo ọcha nke nwere agba na-acha odo odo, okirikiri, ewepụghị, nwere afụ ọnụ, nwere eriri mmebi n'akụkụ abụọ ya na 4 nicks n'akụkụ.

Ndị na-ewepụta oge: otu copolymer nke ethyl acrylate, methyl methacrylate na trimethylammonioethyl methacrylate (1: 2: 0.1) (Eudragit RS30D), triacetin, talc, copolymer nke methacico acid na ethyl acrylate (1: 1) microudlallallallallallallallallus, 60 Mall stereta magnesium.

10 PC. - blisters (5) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (5) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (3) - ngwugwu nke kaadiboodu.
10 PC. - ngwugwu ọnya (4) - ngwugwu nke kaadiboodu.

Wụnye n'otu n'otu. Mgbe a na -ekwu ya ọnụ maka ndị okenye na ndị nọ n'afọ iri na ise gbagoro, ọgwụ izizi bụ 100-400 mg. Ọ bụrụ na ọ dị mkpa, ma na-eburu n'uche mmetụta ụlọ ọgwụ, a na-abawanye dose ahụ site na ihe na-erughị 200 mg / ụbọchị na nkeji nke 1 izu. Oge nchịkwa dị ugboro 1-4 / ụbọchị. Ọgwụ nchekwa na-abụkarị 600-1200 mg / ụbọchị n'ọtụtụ usoro. Oge ọgwụgwọ ọ dabere na njirimara, arụmọrụ nke ọgwụgwọ, nzaghachi onye ọrịa na usoro ọgwụgwọ.

N'ime ụmụaka na-erubeghị afọ 6, a na-eji 10-20 mg / kg / ụbọchị mee ihe na 2-3 kewara, ma ọ bụrụ na ọ dị mkpa ma na-eburu n'uche nnabata, a na-abawanye dose ahụ site na-erughị 100 mg / ụbọchị na nkeji nke 1 izu, oge mmezi na-abụkarị 250 -350 mg / ụbọchị ma ọ gafere 400 mg / ụbọchị. Agedmụaka dị afọ 6-12 - 100 mg ugboro abụọ / ụbọchị n’ụbọchị mbụ, mgbe ahụ, a na-abawanye ọgwụ ahụ site na 100 mg / ụbọchị na oge dị ka 1 izu. ruo mgbe nsonaazụ kachasị mma, usoro mmezi na-abụkarị 400-800 mg / ụbọchị.

Doses kachasị: mgbe ejiri ọnụ mee ya, ndị okenye na ndị nọ n'afọ iri na ụma dị afọ 15 gbago - 1.2 g / ụbọchị, ụmụaka - 1 g / ụbọchị.

Mmekorita

N'iji oge nke egbochi ndị na - egbochi isoenzyme CYP3A4, mmụba nke mkpokọta carbamazepine na plasma ọbara.

Site n'iji ihe nnabata nke CYP3A4 isoenzyme n'otu oge, ngwangwa metabolism nke carbamazepine, mbelata nke itinye uche ya na plasma ọbara, na mbelata nke ọgwụgwọ ọgwụgwọ enwere ike.

N'iji oge nke carbamazepine na-akpali metabolism nke anticoagulants, folic acid.

N'iji ojiji nke acid a na-eme n'otu oge, mbelata nke ịta ahụhụ nke carbamazepine na mbelata nke ịta ụba nke valproic acid na plasma ọbara. N'otu oge ahụ, itinye uche nke carbamazepine metabolite, carbamazepine epoxide, na-abawanye (ikekwe n'ihi ihe mgbochi nke ntụgharị ya na carbamazepine-10,11-trans-diol), nke nwekwara ọrụ anticonvulsant, yabụ, enwere ike ịmịpụta mmetụta nke mkparịta ụka a, mana mmeghachi omume n'akụkụ nwere mgbe ọ bụla - ọhụụ na-enwu gbaa, dizzness, vomiting, adịghị ike, nystagmus. N'iji oge a na - eme ihe nke valproic acid na carbamazepine, mmepe nke mmetụta hepatotoxic ga - ekwe omume (o doro anya, n'ihi nguzobe metabolite nke valproic acid, nke nwere mmetụta hepatotoxic).

Iji otu oge, valpromide na-ebelata metabolism na imeju nke carbamazepine na metabolite carbamazepine-epoxide n'ihi mgbochi nke hydrozy nke enzyme. Metabolite ahụ akọwapụtara nwere ọrụ anticonvulsant, mana na mmụba dị ukwuu na mkpokọta plasma ọ nwere ike ịnwe nsí.

Iji otu oge eji verapamil, diltiazem, isoniazid, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide (na okenye, naanị na nnukwu onyonyo), erythromycin, troleandrom, ya na -anara ya, ya na -anakarị, ya na -anakarị, ya na -anakarị, ya na -anakarị, ya na -anakarị, ya na -anyere ya, ya bụ, gụnyere ya na itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, mmụba nke ịta ahụhụ nke carbamazepine na plasma ọbara nwere ike iji ihe egwu nke mmetụta azụ (ọgbụgba, iro ụra, ataxia, diplopia).

N'iji ya na hexamidine eme ihe, mmetụta anticonvulsant nke carbamazepine adịghị ike, ya na hydrochlorothiazide, furosemide - enwere ike belata ọdịnaya sodium n'ime ọbara, yana mgbochi homonụ - enwere ike imebi mmetụta nke ọgwụ mgbochi yana mmepe nke ọbara ọgbụgba.

Site n'iji homonụ thyroid eme ihe n'otu oge, ọ ga-enwe ike ịbawanye mkpochapụ homonụ thyroid, yana clonazepam, ọ ga-ekwe omume ịbawanye nkpuchi nke clonazepam ma belata nhichapụ nke carbamazepine, na nkwadebe lithium, nkwalite mmekọrịta nke mmetụta neurotoxic ga-ekwe omume.

Site n'iji primidone mee ihe n'otu oge, mbelata mkpokoro carbamazepine na plasma ọbara. Enwere akụkọ na primidone nwere ike ịbawanye uru plasma nke ọgwụ na-arụ ọrụ metabolacologically - carbamazepine-10,11-epoxide.

Iji ojiji n'otu oge na ritonavir, enwere ike ịkwalite nsonaazụ nke carbamazepine, yana sertraline, mbelata mkpokọta nke sertraline ga-ekwe omume, yana theophylline, rifampicin, cisplatin, doxorubicin, mbelata mkpo nke carbamazepine na plasma ọbara, nwere tetracycline, nwere ike belata belata, nwere ike nke belata carinebena.

N'iji iji ogwu eme ihe n'otu oge, mbelata mkpokoro nke carbamazepine na plasma ọbara, enwere ike, ma mmụba na mkpokọta metabolites na-arụ ọrụ nke carbamazepine-epoxide, ebe mbelata nke ịta na plasma nke felbamate ga-ekwe omume.

N'iji ojiji oge a na phenytoin, phenobarbital, mkpokọta carbamazepine na plasma ọbara na-ebelata. Imebi ihe anticonvulsant na ogbaaghara kwere omume, ma n’oge obere, ike ya.

Nsonaazụ

Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: mgbe - ọgbụgba, ataxia, iro ụra, isi ọwụwa, diplopia, nsogbu ụlọ, adịkarịghị - mkpali mmegharị, nystagmus, n'ụfọdụ ọnọdụ - oculomotor ọgba aghara, dysarthria, nsogbu akwara akụkụ, paresthesia, ike ọgwụgwụ, mgbaàmà paresis, hallucinations, ịda mba, ike ọgwụgwụ, omume na-eme ihe ike, mkpasu iwe, mmụọ na-adịghị mma, ụbụrụ na-abawanye, uto uto, conjunctivitis, tinnitus, hyperacusis.

Site na usoro nri: ọgbụgbọ, GGT mụbara, ọrụ nke alkaline phosphatase, vomiting, ọnụ akọrọ, adịkarịghị - mụbara ọrụ nke transaminases, jaundice, cholestatic hepatitis, afọ ọsịsa ma ọ bụ afọ ntachi, n'ọnọdụ ụfọdụ - agụụ nri, afọ mgbu, glossitis, stomatitis.

Site na usoro akwara obi: adighi ike - myocardial conduction disturbances, on the these - bradycardia, arrhythmias, AV blockade with syncope, ida, obi na adighi, ngosiputa nke coronary insufficiency, thrombophlebitis, thromboembolism.

Site na usoro hemopoietic: leukopenia, eosinophilia, thrombocytopenia, adịkarịghị - leukocytosis, n'ọnọdụ ụfọdụ - agranulocytosis, aplastic anlasia, erythrocytic aplasia, megaloblastic anaemia, reticulocytosis, hemolytic anaemia, granulomatous hepatitis.

Site na akụkụ nke metabolism: hyponatremia, njigide mmiri, edema, uru ahụ, mbelata plasma osmolality, n'ọnọdụ ụfọdụ - nnukwu ihe na-efe efe porphyria, ụkọ folic acid, nsogbu metabolism, ịba ụba cholesterol na triglycerides.

Site na usoro endocrine: gynecomastia ma ọ bụ galactorrhea, adịkarịghị - nsị thyroid.

Site na sistemụ urinary: ọ na - adịkarịghị - arụ ọrụ akụrụngwa arụ, nephritis interstitial na ọdịda akụrụ.

Site na usoro iku ume: n'ọnọdụ ụfọdụ - dyspnea, oyi baa ma ọ bụ oyi baa.

Mmeghachi omume nfụkasị: ọnya anụ ahụ, itching, adịkarịghị - lymphadenopathy, ahụ ọkụ, ịba ọcha n'anya, ọrịa ogbu na nkwonkwo.

Akwụkwụ na-adọ: nnukwu, nlegharị anya, agwakọta (gụnyere nnukwu ọdịmma) ọdịkwụkwụ. Ọrịa mgbu mgbu kachasị nke sitere na neurogenic sitere, gụnyere neuralgia trigeminal dị mkpali, trigeminal neuralgia na otutu sclerosis, glossopharyngeal neuralgia dị mkpa. Mgbochi ọgụ na ọrịa ịkwụsịlata mmanya. Psycho emetụta na schizoaffective (dị ka ụzọ mgbochi). Ọrịa mamịrị na-arịa ọrịa mamịrị. Ọrịa shuga bụ isi mmalite, polyuria na polydipsia nke akwara neurohormonal.

Ime na lactation

Ọ bụrụ na ọ dị mkpa, jiri n'oge afọ ime (karịchaa na ọkara nke mbụ) na n'oge a ga-eji nlezianya tụọ uru ịtụle ọgwụgwọ dịịrị nne na ihe ọghọm nye nwa ebu n’afọ ma ọ bụ nwa. N'okwu a, a na-atụ aro ka carbamazepine jiri naanị monotherapy na usoro opekempe.

Mụ nwanyị ịmụ nwa n’oge a na-eji ọgwụ carbamazepine agwọ ọrịa ka a na-atụ aro iji ọgwụ mgbochi na-abụghị hormonụ.

Ntụziaka pụrụ iche

Ejighi Carbamazepine mee ihe ma ọ bụ n'ọrịa ọdịdọ, myoclonic ma ọ bụ atonic arịa ọdịdọ. Ekwesighi iji ya belata ihe mgbu nkịtị, dịka prophylactic n'oge oge ogologo oge mgbaghara nke trigeminal neuralgia.

A na-eji ya akpachara anya ma ọ bụrụ na ọrịa ndị na - akpata nkụja, akwara na - arụ ọrụ akwara, na - arịa ọrịa hyatoatremia, njide na urinary, ma nwekwuo mmetụta nke ọgwụ mgbochi ọrịa tricyclic tricyclic. , yana ihe ngosi banyere akụkọ banyere nkwụsị nke ọgwụgwọ carbamazepine, yana ụmụaka na ndị ọrịa agadi.

Ekwesịrị ịgwọ ọrịa n'okpuru nlekọta nke dibịa. Site na ọgwụgwọ ogologo oge, ọ dị mkpa ijikwa eserese ọbara, ọnọdụ imeju na akụrụngwa, ọrụ nke electrolytes na plasma ọbara, yana nyocha nke ophthalmological. A na-atụ aro mkpebi oge nke ọkwa nke carbamazepine na plasma ọbara iji nyochaa ịdị irè na nchekwa nke ọgwụgwọ.

Ọ dịkarịa ala izu abụọ tupu ịmalite ọgwụgwọ carbamazepine, ọ dị mkpa ịkwụsị ọgwụgwọ na ndị na-egbochi MAO.

N'oge ọgwụgwọ adịghị ekwe ka mmanya.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge ọgwụgwọ, mmadụ kwesịrị ịhapụ itinye aka n'ihe omume dị oke njọ nke chọrọ nlebara anya, yana ọsọ nke mmeghachi omume psychomotor.

ọgwụ ọgwụ . Finlepsin retard bụ usoro anticonvulsant sitere na tinoyclic iminostilbene tricyclic. O gosiputara antiepileptik, neurotropic na psychotropic. Mmetụta ọgwụgwọ bụ isi n'ihi mgbochi nke mgbasa nke synaptik nke excitation, n'ihi nke a, mbelata mgbasa nke mwakpo nkwenye. N'elu mkpokoro dị elu, carbamazepine na-ebute mbelata ike nke tetanic. Finlepsin retard na-ebelata oke ihe mgbu na trigeminal neuralgia. Mmetụta a bụ n'ihi mgbochi nke nnyefe synaptik nke mgbakasị ahụ n'ime akwara azụ nke akwara trigeminal. Na ọrịa insipidus nke ọrịa shuga, Finlepsin retard nwere mmetụta antidiuretic, ikekwe n'ihi mmetụta hypothalamic na osmoreceptors.

Mlọ ọgwụ Mgbe nchịkwa ọnụ gachara, a na-etinye carbamazepine nwayọ nwayọ ma ọlị.

Oge ndụ ọkara bụ awa 8.5 ma nwee oke (ihe dịka 1.72-12 awa). Mgbe otu mkpụrụ ọgwụ C nke zuru ezu, a na-enweta carbamazepine na plasma ọbara n'ime ndị okenye mgbe awa 4-16 gasịrị (ọ dịkarịsịrị obere mgbe ọ gachara awa 35), n'ime ụmụaka ka ọ gbasachara awa anọ na isii. mgbe a na-eji ya na elu doses, usoro ịta plasma nwere ọdịdị nke plateau.

Mgbe a na-eji mbadamba nkume ndị nwere ogologo oge, a na-enweta ntakịrị mkpo ala nke carbamazepine na plasma ọbara karịa na mbadamba ndị ị na-emebu.

Ekwesịrị itinye uche itinye uche mgbe ụbọchị 2-8 gachara. Enweghi nkwekorita di nso n'etiti ogwu nke carbamazepine na ntinye uche kwụsie ike na nhazi nke ọbara na plasma.

Banyere ọgwụgwọ nke carbamazepine na-egbu egbu na plasma ọbara, a na-egosi na ọdịdọ nwere ike ịpụ na ọkwa plasma nke 4-12 μg / ml. Ta ọgwụ ahụ na plasma ọbara karịrị 20 μg / ml, na-emebi foto ahụ.

Finlepsin retard na mkpokọta nke ihe na-arụ ọrụ na plasma ọbara nke 5-18 μg / ml na-ewepụ ihe mgbu nke trigeminal neuralgia.

70-80% nke carbamazepine na-ejikọ protein protein. Akụkụ carbamazepine enweghị ngwakọta na protein na mkpokọta nke 50 μg / ml ka ga-agbanwe. 48-53% nke ọgwụ ọgwụ na-arụ ọrụ metabolite carbamazepine-10, 11-epoxide na-egbochi protein ndị dị na plasma. Ntinye uche nke carbamazepine na CSF bụ 33% nke ịta plasma.

Carbamazepine na-agafe ihe mgbochi placental ma na-apụ apụ na mmiri ara.

Mgbe ịbụsịrị otu ọgwụ, carbamazepine dị na plasma ọbara site na awa T ½ 36. Site na ọgwụgwọ ogologo oge, T ½ na-agbada site na 50% n'ihi ntinye nke enzymes imeju microsomal.

N'ebe ndị mmadụ dị mma, mkpochapu sitere na plasma ọbara dị ihe dị ka 19.8 ml / h / n'arọ ahụ, na ndị ọrịa nwere monotherapy - ihe dịka 54.6 ml / h / n'arọ, na ndị ọrịa nwere ọgwụgwọ ejikọtara ọnụ - ihe dịka 113.3 ml / h / n'arọ

Mgbe otu mkpụrụokwu nke carbamazepine na-ejikwa ọnụ mee ihe, 72% nke ụdị n'ụdị metabolites na-apụ site n'ahụ ahụ site na akụrụ. Ihe ndị ọzọ dị 28% bụ anụ ahụ na anụ ure, akụkụ ụfọdụ - agbanweghị. Naanị 2-3% nke ihe dị na mmamịrị bụ carbamazepine anaghị agbanwe agbanwe.

Akwụkwụ na-adọ: enwere ọdịdọ akụkụ ma ọ bụ dị mfe nghọta (enwere ma ọ bụ na-enweghị nnukwu nsonazụ) na ma ọ bụ na-enweghị site na ngwụcha nke abụọ, usoro ọdịdọ tonic-clonic, ụdị ọdịdọ dị iche iche.

Enwere ike iji retlepsin retard mee ihe dịka monotherapy yana dịka akụkụ nke ọgwụgwọ njikọta.

Ọnọdụ manic na-adịghị ala ala, usoro ọgwụgwọ na-akwado ọrịa na-emetụta ọnụnọ iji gbochie nsogbu ma ọ bụ iji belata ogo ngosipụta nke ọrịa na-akpata iwe.

Ọrịa ị withdrawalụ mmanya.

Idiopathic trigeminal neuralgia na trigeminal neuralgia na otutu sclerosis (nke a na-ahụkarị na nke).

Idiopathic neuralgia nke akwara glossopharyngeal.

A na-edepụta Finlepsin retard na ede, na-abụkarị mkpụrụ ọgwụ kwa ụbọchị kwesiri ịkewa abụọ. Nwere ike ị theụ ọgwụ n’oge, mgbe nri gachara ma ọ bụ n’etiti nri, na obere mmiri mmiri.

Tupu ịmalite ọgwụgwọ, ndị ọrịa sitere na agbụrụ China Han ma ọ bụ ndị ọrịa sitere na Thai kwesịrị ka enyocha ya maka HLA-B * 1502, ebe ọ bụ na nke a nwere ike ịkpalite mmepe nke nnukwu ọrịa metụtara ọrịa carbamazepine Stevens-Johnson.

Akwụkwụ na-adọ Ọgwụgwọ na-amalite site n'iji obere ọgwụ kwa ụbọchị, nke a na-eji nwayọ nwayọ (na-emegharị, na-eburu n'uche mkpa onye ọrịa ọ bụla) ruo mgbe a ga-enweta nsonaazụ kachasị mma.

N'ọnọdụ ebe nke a ga - ekwe omume, ekwesịrị ịkọwa Finlepsin retard dị ka monotherapy, mana mgbe ejiri ọgwụ ndị ọzọ mee ihe, a na-atụ aro usoro otu mmụba ahụ na ogo ọgwụ ahụ. Ọ bụrụ na agbakwunyere Finlepsin retard na ọgwụ antiepileptik dị, a ga-abawanye dose ahụ nwayọ, ebe a naghị agbanwe ma ọ bụ gbanwee usoro nke ọgwụ ndị eji eme ihe ma ọ bụrụ na ọ dị mkpa.

Iji họrọ ezigbo ọgwụ ọgwụ ahụ, ọ nwere ike ịba uru ikpebi ọkwa nke ihe na-arụ ọrụ n'ime plasma ọbara. Ọgwụ ịgwọ ọrịa ọgwụ na plasma ọbara kwesịrị 4-12 μg / ml.

N'ime ụfọdụ ndị ọrịa, n'iji mbadamba ọgwụ retard, ọ nwere ike ịdị mkpa ka iwelie dose nke ọgwụ.

Ndị okenye Ọgwụ akwadoro ka akwadoro bụ 100-200 mg 1-2 ugboro kwa ụbọchị, mgbe ahụ, a ga-eji nwayọ nwayọ were mee ihe ruo mgbe arụpụtara ezigbo ya, na-abụkarị ọgwụ kwa ụbọchị bụ 800-1200 mg, nke kewara abụọ. Patientsfọdụ ndị ọrịa nwere ike ịchọ ọgwụ Finlepsin retard na-eru 1600 mg ma ọ bụ ọbụna 2000 mg / ụbọchị.

Ndị okenye na-arịa ọrịa. Nyere mmekorita nke ogwu na udiri ogwu di iche iche nke ọgwụ antiepileptiki, ekwesiri ịhota ndi oria okenye site na nlezianya na usoro ogwu retlepsin.

Frommụaka ndị gbara afọ 5. Ọtụtụ mgbe, a ga-ebu ọgwụgwọ n'ọtụtụ nke ahụike 10-20 mg / n'arọ kwa ụbọchị (n'ọtụtụ usoro).

Agedmụaka gbara afọ 5-10 - 400-600 mg / ụbọchị.

Agedmụaka gbara afọ 10-15 - 600-1000 mg / ụbọchị.

Ọnọdụ manic na-adịghị mma na ọgwụgwọ na-akwado ọrịa. Ọgwụ ọnụọgụ bụ 400-1600 mg / ụbọchị na usoro 2 kewara.

N’ezie, a na-eme ọgwụgwọ n’otu ọgwụ nke 400-600 mg / ụbọchị n’ime usoro abụọ kewara. Na ọgwụgwọ nke ọrịa manic, a ga-abawanye dose nke Finlepsin retard ngwa ngwa ka 800 mg / ụbọchị. Site na ọgwụgwọ mmezi maka ọrịa ụbụrụ, a na-atụ aro ka mmụba nwayọ nwayọ dị ala iji hụ na nnabata zuru oke.

Mmanya na-a withdrawalụ mmanya. Ọkara bụ 600 mg / ụbọchị n’ime usoro 2 kewara. N'okwu ndị siri ike, enwere ike ịbawanye ọnụọgụ ahụ n'ime ụbọchị ole na ole mbụ (dịka ọmụmaatụ, ruo 1200 mg / ụbọchị, kewara n'ime usoro 2). Na ngosipụta siri ike nke iwepụ mmanya, ọgwụgwọ na-amalite site na nchikota Finlepsin retard na ọgwụ mgbochi ọgwụ (dịka ọmụmaatụ, clomethiazole, chlordiazepoxide), na-agbaso ntuziaka usoro ọgwụgwọ ahụ dị n'elu. Mgbe emechara usoro a dị oke njọ, ọgwụgwọ Finlepsin retard nwere ike ịga n'ihu dị ka monotherapy.

Idiopathic trigeminal neuralgia na trigeminal neuralgia na otutu sclerosis (nke a na-ahụkarị na nke). Idiopathic neuralgia nke akwara glossopharyngeal. Ọgwụ nke Finlepsin Retard bụ 200-400 mg / ụbọchị (100 mg ugboro abụọ n'ụbọchị maka ndị ọrịa agadi). Ekwesiri iji nwayọọ nwayọọ mụbaa ruo mgbe ihe mgbu na-apụ n'anya (ọ na-abụkarị ọnụọgụ 400-800 mg, kewara 1-2 usoro). N'ọnọdụ ụfọdụ, enwere ike ịchọ ọgwụ kwa ụbọchị nke 1600 mg. Mgbe ịkwụsị ihe mgbu, a ga-eji nwayọ belata dose ahụ ka ọ bụrụ mmezi kacha nta.

Ekwenyeghị Finlepsin Retard:

• nwere ọgwụ ike a na-egosi na carbamazepine ma ọ bụ ọgwụ ndị yiri nke ahụ (tricyclic antidepressants), ma ọ bụ akụkụ ndị ọzọ nke ọgwụ ahụ.
• ya na AV mgbochi,
• akụkọ banyere mgbochi ụmị ọkpụkpụ,
• ndị ọrịa nwere akụkọ banyere ọrịa ịba ọcha n'anya (wdg., nnukwu efe efe porphyria, porphyria agwakọta, mbubreyo akpụkpọ ahụ),
• yana MAO inhibitors,
• yana voriconazole, dika ọgwụgwọ nwere ike ọgaghị adaba.

Nsonaazụ ndị akọwapụtara na-abụkarị na usoro ọgwụgwọ ejikọtara karịa nke monotherapy. Dabere na dose na tumadi na mmalite nke ọgwụgwọ, ụfọdụ mmetụta nwere ike ime. Na mkpokọta, ha na-apụ n'anya n'onwe ha mgbe ụbọchị 8-14 gachara ma ọ bụ mbelata obere oge.

N'akụkụ ọbara na sistem lymphatic: leukocytosis, eosinophilia, leukopenia, thrombocytopenia, folic acid defensive, agranulocytosis, aplastic anemia, pancytopenia, erythrocytic aplasia, anemia, megaloblastic anemia, nnukwu intermittent porphyria, variegative porphyria hemorrhage late.

Si dịghịzi usoro: ọgwụ ịba ọcha n'anya na eosinophilia na mgbaàmà systemic (DRESS), egbu oge ịba ọcha n'anya ọrịa, akpịrị anụ, vasculitis, lymphadenopathy, akara yiri lymphoma, arthralgia, leukopenia, eosinophilia, hepatosplenomegaly na ndị na - adịghị ahụkebe ya na ọrịa ọnya dị iche iche, na - arịa ọrịa na - enweghị isi dị iche iche, na - arịa ọrịa na - enweghị isi dị iche iche, na - arịa ọrịa na - adịghị arụ ọrụ dị iche iche, na - arịa ọrịa na - adịghị arụ ọrụ dị iche iche bile ducts (mbibi na mfu nke intrahepatic bile ducts), aseptic meningitis with myoclonus na perispheral eosinophilia, anaphylactic mmeghachi omume, angioedema, hypogammaglobulinemia. Akụkụ akụkụ ndị ọzọ (dịka, imeju, akpa ume, akụrụ, pancreas, myocardium, nnukwu eriri afọ) nwere ike itinye aka.

Site na usoro endocrine: edema, njigide mmiri, ibu ibu, hyponatremia na mbelata osmolarity ọbara plasma site na nsonaazụ carbamazepine, nke yiri homonụ antidiuretic, nke na-eduga na hyperhydration mgbe ụfọdụ, nke a na-esite n'ọgba aghara, ọgbụgbọ, isi ọwụwa, ọgba aghara na nsogbu akwara ozi, mụbara ọkwa prolactin na ma ọ bụ na-enweghị mgbaàmà nke ọrịa dịka galactorrhea na gynecomastia, nsonaazụ na-adịghị mma nke ule ọrụ thyroid: mbelata nke ọkwa L-thyroxine (FT 4, T 4, T 3) na mmụba na TSH, nke na - apụkarị na - enweghị ngosipụta nke ụlọ ọgwụ, na - egbochi metabolism nke ọkpụkpụ (mbelata plasma calcium na 25-hydroxycolecalciferol na plasma ọbara), na - eduga na osteomalacia / osteoporosis, mmụba nke cholesterol, gụnyere HDL cholesterol na triglycerides. Carbamazepine nwere ike belata ọkwa plasma. Mbelata na ọkwa plasma nke vitamin B 12 n’okpuru mmetụta nke carbamazepine na mmụba na ọkwa homocysteine.

Si n'akụkụ metabolism na nsogbu iri nri: ụkọ nri, nri anaghị eriju afọ, nnukwu porphyria, ụkwara ume ọkụ.

Site n'akụkụ nke psyche: hallucinations (visual ma ọ bụ odide), ịda mba, enweghị agụụ, nchegbu, omume ike, iwe, oke ụjọ, ọgba aghara, ịba ụba latent psychosis, mgbanwe ọnọdụ, dị ka ịda mbà ma ọ bụ manic swings, phobias, enweghị mkpali, mmeghari mkpali, dị ka asterixis.

Si ụjọ usoro: ike ọgwụgwụ, ike ọgwụgwụ, ataxia, iro ụra, ịda mba, ike ọgwụgwụ, isi ọwụwa, mmegharị ahụ na - adịghị mma (dịka ọmụmaatụ oke ụjọ, oke isi, dystonia, tic), nystagmus, orofacial dyskinesia, echiche dị nwayọ, ọgba aghara okwu (dịka dysarthria ma ọ bụ okwu nzuzu), choreoathetosis, neuropathy akụkụ, paresthesia, ike ọgwụgwụ na paresis, uto erughị ala, ọrịa antipsychotic syndrome, nkwarụ ncheta, atailia na ọrịa ụbụrụ, bụ nke isi ọwụwa na-eso ya mgbe ụfọdụ. oh mgbu.

Site n'akụkụ akụkụ ahụ nke ọhụụ: conjunctivitis, ebe obibi na-adịghị mma (diplopia, ọhụụ na-acha uhie uhie), ịba ụba intraocular mgbali, igwe ojii nke oghere, retinotoxicity, ọgba aghara nke oculomotor.

Site n'akụkụ akụkụ ahụ nke ịnụ ihe na ngwa agha: nkwarụ ntị, tinnitus, tinnitus, hyperacusis, hypoacusia, echiche nke nsogbu.

Si usoro obi: intracardiac conduction disturbances, bradycardia, arrhythmia, na-aka njọ nke akwara obi, ọrịa obi na -akpọ, ọrịa mgbasa, AV mgbochi na syncope, ọbara mgbali elu ma ọ bụ hypotension, vasculitis, thrombophlebitis, thromboembolism (e.g. pulmonary embolism).

hypersensitivity sitere na ngụgụ, bụ nke e ji mara mmụba nke ahụ, oke ume, pulmonitis ma ọ bụ oyi baa. N'ọnọdụ mmeghachi omume hypers dị otú ahụ, ekwesịrị ịkwụsị ọgwụ a.

afọ nri, akpịrị ịkpọ nkụ, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, afọ ntachi, afọ mgbu, stomatitis, gingivitis, glossitis, pancreatitis, colitis.

Ọrịa hepatobiliary: mgbanwe na ngosipụta nke nyocha imeju na-arụ ọrụ (mmụba nke gamma-glutamyl transferase, ọkwa nke alkaline phosphatase, transaminases), jaundice, ụdị dị iche iche nke ịba ọcha n'anya (cholestatic, hepatocellular, granulomatous, agwakọta), ọrịa ịba ọcha n'anya na-egbu ndụ, ọrịa imeju.

N'aka anụ ahụ na abụba subcutaneous: nrịanrịa akpịrị, urticaria, pruritus, exfoliative dermatitis, erythroderma, necrosis nke akpukpọ anụ ahụ na ọnya ọnya (ọrịa Lyell), ọnya na-acha ọbara ọbara, na-acha uhie uhie na polymorphic rashes n'ụdị ntụpọ na usoro nke ọnya, nwere ọbara ọgbụgba (exudative erytheme etshema Stevens-Johnson), ọnya ọbara petechial na akpụkpọ ahụ na lupus erythematosus (mgbasa ozi lupus erythematosus, alopecia), diaphoresis, mgbanwe na ụcha akpụkpọ ahụ, ihe otutu, hirsutism, vasculitis, pu pura, mụbara sweating, nnukwu generalized exanthematous pustulosis (AGEP), lichenoid keratosis, onihomadez.

Site na usoro mọzụlụ: arthralgia, myalgia, ihe nro n’ọkpụkpụ olu, mgbu akwara, ọnya na-ebelata, njupụta nke mmebi nke ọkpụkpụ.

Site na akụrụ na eriri afọ: proteinuria, hematuria, oliguria, dysuria, pollakiuria, reserve urinary, tubulointerstitial nephritis, ọdịda akụrụ, ụba urea / azotemia ọbara, ure ugboro ugboro.

Site na usoro omumu na ara mammary: mmebi nke spermatogenesis (site na ibelata ọnụọgụ na / ma ọ bụ ọnọdụ nke spermatozoa), dysfunction erectile, enweghi ike, belata agụụ mmekọahụ.

Ọrịa na infestations: ntughari nke oria virus herpes nke mmadu.

Mbibi nke nyocha nnwale nke ụlọ nyocha: hypogammaglobulinemia.

Ekwesịrị ka ekwenye carbamazepine naanị na nlekọta nlekọta ahụike, naanị mgbe ọ tụlechara uru / ihe ọghọm ruru ma dabere na nlezianya nke ndị ọrịa nwere akụkọ gbasara ọrịa obi, ọrịa hepatic ma ọ bụ akụrụ, mmerụ ahụ na-emetụta ọgwụ ndị ọzọ, ma ọ bụ ndị ọrịa nwere ọgwụ carbamazepine etre.

Carbamazepine na-egosipụta ọrụ anticholinergic dị nro, yabụ, ndị ọrịa nwere nrụgide intraocular na-aba ụba ka a dọọ aka na ntị ma kparịta banyere ihe ndị nwere ike ibute ya.

Ekwesiri icheta banyere o kwere omume na-arụ ọrụ nke latent psychoses, yana n'ihe metụtara ndị ọrịa agadi - banyere mmegharị nke kwere omume nke mgbagha na mmepe nke mkpasu iwe.

Ọgwụ anaghị adịkarị mma maka abịaghị (obere ọdịdọ) na ọdị myoclonic. Oge ụfọdụ na-egosi na ọdịdọ abawanye nwere ike ibute na ndị ọrịa nwere ọnụnọ enweghị isi.

Mmetụta hematologic. Ojiji nke iji ọgwụ a jikọtara ya na mmepe nke agranulocytosis na ọrịa aklaulo, mana n'ihi oke ọnọdụ nke ọnọdụ ndị a, o siri ike ịtụle ihe egwu dị ukwuu mgbe ị na-ewere carbamazepine.

Ekwesịrị ịgwa ndị ọrịa banyere ihe ịrịba ama nke mbụ nke egbu egbu na ihe mgbaàmà nke ọrịa ọgbụgba ọbara, yana ihe mgbaàmà nke ọgwụ akpịrị na akwara. E kwesịrị ịdọ onye ọrịa ahụ ndụmọdụ na ihe omume mmeghachi omume dịka ọkụ, akpịrị, ọnya anụ ahụ, ọnya ọnụ, ọnya na-eme n'ụzọ dị mfe, ịma ọkwa ọbara ma ọ bụ purpura hemorrhagic, ị kwesịrị ịkpọtụrụ dọkịta ozugbo.

Ọ bụrụ na ọnụ ọgụgụ nke leukocytes ma ọ bụ platelet na-agbadata nke ukwuu n'oge ọgwụgwọ, ekwesịrị ilebara ọnọdụ onye ọrịa ahụ anya, a ga-enyochakwa nyocha ọbara niile nke onye ọrịa ahụ. A ga-akwụsị ịgwọ ya na carbamazepine ma ọ bụrụ na onye ọrịa ahụ etolite leukopenia, nke siri ike, na-aga n’ihu, ma ọ bụ ya na ngosipụta ụlọ ọgwụ, dị ka ahụ ọkụ ma ọ bụ akpịrị mgbu. Ekwesịrị ịkwụsị nke carbamazepine mgbe akara nke mgbochi nke ụmị ọkpụkpụ.

Site n'oge ruo n'oge ma ọ bụ oge, enwere nbelata oge ụfọdụ ma ọ bụ nke na-apụtaghị ìhè na platelet ma ọ bụ leukocytes n'ihe metụtara ị carụ carbamazepine. Agbanyeghị, maka ọtụtụ n'ime okwu ndị a, ekwenyela na anabataghị ihe ha bụ oge ha na-egosighi mmepe nke anaemia ma ọ bụ agranulocytosis. Tupu ịmalite usoro ọgwụgwọ na oge ụfọdụ n'oge omume ya, ekwesịrị ime nyocha ọbara, gụnyere mkpebi nke ọnụ ọgụgụ platelet (yana ike, ọnụọgụ nke reticulocytes na ọkwa nke haemoglobin).

Reactionskpa oke agwa. Mmeghachi omume anụ ahụ dị egwu, gụnyere ọgwụ na-egbu egbu necrolysis (TEN) ma ọ bụ ọrịa Lyell, Stevens-Johnson syndrome (SJS), nwere obere ụkọ na carbamazepine. Ndị ọrịa nwere nnukwu ọgwụ n'ụra nwere ike ịchọ ụlọ ọgwụ, ebe ọnọdụ ndị a nwere ike ibute ndụ egwu ma nwee nsonaazụ na-egbu ya. Otutu ikpe SJS / TEN na-etolite n'ime ọnwa ole na ole mbụ ọgwụgwọ carbamazepine. Site na mmepe nke akara na akara ngosipụta nke ajọ mmeghachi omume akpọnwụ akpọnwụ (SJS, Lyell's syndrome / TEN), ekwesịrị ịkwụsị carbamazepine ozugbo ma ekwenyeghị usoro ọgwụgwọ ọzọ.

Pharmacogenomics. Enwere ihe akaebe na-egosiwanye ike nke nsonaazụ HLA dị iche iche na nkwarụ nke onye ọrịa maka mmeghachi omume ọjọọ metụtara usoro ahụ ji alụso ọrịa ọgụ.

Nkwurita okwu na (HLA) -B * 1502. Ọmụmụ nyocha azụ na ndị ọrịa China nke agbụrụ Khan gosipụtara mmekọrịta dị n'etiti mmeghachi omume anụ ahụ nke SJS / TEN metụtara carbamazepine yana ọnụnọ nke mmadụ leukocyte antigen (HLA), allele (HLA) -B * 1502 na ndị ọrịa a. Otutu ihe akuko banyere mmepe nke SJS (karie ihe na adighi adike) bu njiri mara nke obodo ufodu di na Eshia (dika imaatu, agwaetiti Taiwan, Malaysia na Philippines), ebe okwuru (HLA) -B * 1502 bu nke ndi mmadu. Ọnụ ọgụgụ ndị na-ebu ugwu a dị n'etiti ndị Eshia bụ> 15% na Philippines, Thailand, Hong Kong na Malaysia, ≈10% - na Fr. Taiwan, ihe fọrọ nke nta ka ọ bụrụ 4% - na Northern China, ≈2-4% - na South Asia (gụnyere India) na ụdị usoro onunu ogwu: & nbsp mbadamba ihe mejupụtara:

Otu mbadamba 1 nwere:

ike ihe : carbamazepine 200 mg ma ọ bụ 400 mg,

ndị mgbe ochie : ethyl acrylate, methyl methacrylate na trimethylammonioethyl methacrylate copolymer (Eudragit ® RS 30 D), triacetin, talc, methaclic acid na ethyl acrylate copolymer (Eudragit ® L 30 D-55), microcrystalline celluloone.

Mbadamba tọhapụ nke 200 mg:

Mpempe akwụkwọ 400 mg na-akwadoghị ya: site na-acha ọcha na-acha ọcha na-acha nchara nchara, mbadamba mbadamba ụrọ gbara agba nke nwere akụkụ gbara agba, nwere eriri nke nwere akụkụ abụọ na 4 ihe ngosi n'akụkụ.

Ndị na-ere ọgwụ: ọgwụ antiepileptic ATX: & nbsp

Pharmacodynamics: Ọgwụ antiepileptik (dibịazigine sitere na ya), nke nwekwara ọgwụ antidepressant, antipsychotic na antidiuretic, nwere mmetụta analgesic na ndị ọrịa nwere neuralgia. A na - ejikọta usoro nke ime ihe na mgbochi nke ọwa mmiri sodium voltaji, nke na - eduga na nkwụghachi nke akpụkpọ ahụ nke neurons nke na - ejedebe, na - egbochi ọdịdị nke mwepụ nke neurons yana mbelata nke usoro ihe ọgbụgba synaptik. Na-egbochi iwezigharị ike nke Na + na-arụ ọrụ ike na neurons. Na -ebepụta mwepu nke glutamate neurotransmitter excitatory neurotransmitter, na -ebelata ọnụ ụzọ nhụsi ike nke sistemụ akwara etiti, ma, si otú a, na - ebelata ohere nke ibute ọrịa ọdịdọ. Ọ na - eme ka K + dịkwuo arụmọrụ, gbanwee modulu Ca 2+ nke voltaji, nke nwekwara ike itinye aka na mmetụta anticonvulsant nke ọgwụ.

Ọ dị mma maka ọdịdọ ọdịdọ (akụkụ dị mfe), na-esonye ma ọ bụ anaghị eso ya site na njikwa elu, maka ọdịdọ tonic-clonic jikọtara ọnụ, yana maka ngwakọta nke ụdị ọdịdọ ndị a (anaghị adịkarị mma maka obere ọdịdọ - petit mal, ọnụnọ na myoclonic ọdịdọ. )

Ndị ọrịa nwere akpa akwụkwụ (ọkachasị na ụmụaka na ndị nọ n’afọ iri na ụma) nwere mmetụta dị mma na mgbaàmà nke nchegbu na nkụda mmụọ, yana mbelata mgbakasị ahụ na oke iwe.

Mmetụta na arụmọrụ cognitive na arụmọrụ psychomotor bụ dabere na ntanetị. Mmalite nke mmetụta anticonvulsant dịgasị site na ọtụtụ awa ruo ọtụtụ ụbọchị (mgbe ụfọdụ ruo ọnwa 1 n'ihi nhiwe nke metabolism).

Site na mkpirisi neuralgia trigeminal dị mkpa na nke abụọ n'ọtụtụ oge ọ na-egbochi ọdịdị nke mwakpo mgbu.

Ahụhụ ihe mgbu na trigeminal neuralgia bụ ama ama awa 8-72 gachara.

Site na ọrịa ịwepụ mmanya na-egbu egbu, ọ na-eme ka ọnụ ụzọ dị njikere maka ịdịrị ụkọ, nke a na-ebelata na ọnọdụ a, ma na-ebelata ogo ngosipụta nke ọrịa ahụ nke ọrịa ahụ (ụba iwe, oke ụjọ, ọgba aghara).

Ihe omume antipsychotic (antimaniacal) na-amalite mgbe ụbọchị 7-10 gasịrị, nwere ike ịbụ n'ihi mgbochi nke metabolism nke dopamine na norepinephrine.

Formdị usoro ịsụ ọgwụ ogologo oge na-eme ka enwekwu ohere ịgwọ ọrịa carbamazepine n'ọbara mgbe a na-ewere ya 1-2 ugboro n'ụbọchị.

Aborọsọ bụ nwayọ ma zuru oke (iri nri anaghị emetụta oke ọnụego ya na mmiri.) Mgbe otu mbadamba mbadamba mbadamba, a na-erute itinye uche kachasị mgbe awa 32. A na-erite uru dịkarịsịrị ala nke ihe arụ ọrụ na-agbanweghi agbanwe mgbe otu mgmg anọ nke carbamazepine dị ihe dịka 2.5 μg / ml. A na-enweta ntụpọ ọgwụ ọgwụ na plasma mgbe izu 1-2 gasịrị (ọnụego ihe a rụzuru na-adabere na njirimara nke metabolism: ntinye nke sistem enzyme nke imeju, inwetara site na ọgwụ ndị ọzọ ejiri otu oge), yana ọnọdụ onye ọrịa, ogo ọgwụ na oge ọgwụgwọ. A na - ahụta ọdịiche dị iche iche nke onwe onye na nhazi ịha nhata na usoro ọgwụgwọ: n'ọtụtụ ndị ọrịa, ụkpụrụ ndị a sitere na 4 ruo 12 μg / ml (17-50 μmol / l). Ọta nke carbamazepine-10,11-epoxide (metabolite na-arụ ọrụ metabolite) bụ ihe dịka 30% nke ịta ahụhụ nke carbamazepine. Nkwukọrịta na protein plasma na ụmụaka - 55-59%, na ndị okenye - 70-80%. Ogo o doro anya nke nkesa bụ 0.8-1.9 l / n'arọ. A na-atụgharị uche na mmiri na eriri mmiri nke cerebrospinal, nke kwekọrọ na ọnụego ihe ndị na - arụ ọrụ na - enweghị protein na (20-30%). Penetrates site na ihe mgbochi placental. Ntinye uche na mmiri ara ara bu 25-60% nke ahụ na plasma.

A na-emegharị ya na imeju, ọkachasị n'okporo ụzọ epoxy na ịmalite nke metabolites ndị bụ isi: carbamazepine-10,11-epoxide na-adịghị arụ ọrụ na glucuronic acid. Isi isoenzyme nke na-enye biotransformation nke carbamazepine ka carbamazepine-10,11-epoxide bụ cytochrome P450 (CYP3A4). N'ihi mmeghachi omume metabolic ndị a, etolite metabolite nke 9-hydroxymethyl-10-carbamoylacridane, nke nwere ọrụ ọgwụ na-adịghị ike. nwere ike itinye metabolism nke ya.

Ọkara ndụ nke abụọ ịbatara otu ọgwụ bụ awa 60-100 (nkezi nke ihe ruru awa 70), na iji ogologo oge, ọkara ndụ ahụ ga-ebelata site na itinye aka na sistem enzyme imeju. Mgbe otu mkpụrụokwu nke carbamazepine na-ejikwa ọnụ, 72% nke ọgwụ aewere na-adị na mmamịrị na 28% na feces, ebe ihe dị ka 2% nke ọgwụ a na-ewere dị na mmamịrị ahụ ka carbamazepine na-agbanweghị, yana ihe dịka 1% n'ụdị metabolites 10.11-epoxy.

Enweghị ihe akaebe na ọgwụ ọgwụ nke carbamazepine na-agbanwe na ndị ọrịa agadi.

Akwụkwụ na-adọ: mpụ ọdịdọ nke enweghị usoro (ewezuga ihe anaghị abịara ya), ụdị ịba n'ụdị (dị mfe ma nwee nsogbu dị iche iche), ọdụ ọdịdọ nke nnukwu,

Trigeminal neuralgia,

Idiopathic glossopharyngeal neuralgia,

Ihe mgbu na oke ọgụ akwara na-arịa ọrịa shuga mellitus, ihe mgbu na neuropathy mamịrị,

Akwụkwụ na-adọ nwere otutu sclerosis, ọnya na-eme ka ihe na-egbu mgbu, ọnya ọgbụgba, mkparịta ụka paroxysmal na nkwaghari (paroxysmal dysarthria na ataxia), paroxysmal paresthesias na mgbu nke ahụ,

Mmanya na-a withdrawalụbiga mmanya na-egbu egbu (nchegbu, nkwonkwo, ike ọgwụgwụ, nsogbu ịrahụ ụra),

Ọrịa ụbụrụ (emetụta ihe na nsogbu schizoaffective, psychoses, aghara nke usoro limbic).

Ọgwụ mkpuchi nke carbamazepine na ọgwụ ndị ọzọ, yana ọgwụ mgbochi tricyclic.

Ọgba aghara nke ụmị ọkpụkpụ (anaemia, leukopenia),

Nnukwu ọnụnọ porphyria (gụnyere akụkọ ihe mere eme)

Nlekọta oge nke lithium nkwadebe na MAO inhibitors.

Abụọla nkụda mmụọ na-adịghị ala ala,

Ọrịa hyponatremia (ADH hypersecretion syndrome, hypopituitarism, hypothyroidism, adrenal cortex insufficiency),

Enweghị umeji ọrụ na akụrụ,

Mmanya na-arụ ọrụ (ịda mbà n'obi nke CNS na-arịwanye elu, metabolism carbamazepine na-emesi ike),

Inhibido mgbochi ụyọkọ ọbara na ọgwụ (akụkọ ihe mere eme),

Prostatic hyperplasia

Mmụba intraocular mgbali,

Na mgbakwunye na ọgwụ ogwuura.

Ime na lactation:

Mgbe ọ bụla enwere ike, a na-enye ọgwụ ndị Finlepsin® maka ụmụ ịmụ nwa n'ụdị ọgwụgwọ monotherapy, n'ọtụtụ kachasị dị ala, ebe ọ bụ na ọnụọgụ mmebi iwu ụmụaka amụrụ ọhụrụ site n'aka ndị nne ejirila ọgwụgwọ antiepileptik karịa nke sitere na monotherapy.

Mgbe ime dị, ọ dị mkpa ịtụle uru a tụrụ anya na ọgwụgwọ na nsogbu ndị ọ ga-ekwe omume, ọkachasị n'oge ọnwa atọ mbụ nke ịtụrụ ime.A maara na ụmụaka nke nne na-arịa ọrịa akwụkwụ na-emerịrị ọrịa intrauterine development, tinyere mmejọ. Finlepsin® retard na-enwe ike ịbawanye ohere nke nsogbu ndị a. Enwere akụkọ dịpụrụ adịpụ nke ọrịa nke agbụrụ na arụrụ arụ, gụnyere enweghị mmechi nke vertebral arch (spina bifida).

Ọgwụ Antiepileptic na-abawanye ụkọ folic acid, nke a na-ahụkarị n’oge afọ ime, nke nwere ike ime ka mmerụ ahụ dị n’etiti ụmụaka mụọ, yabụ na-atụ aro ị takingụ folic acid n’ihu ịtụrụ ime na n’oge ime. Iji gbochie nsogbu ọbara ọgbụgba n'ime ụmụ amụrụ ọhụrụ, a na-atụ aro ụmụ nwanyị n'ime izu ikpeazụ nke ime afọ, yana ụmụ amụrụ ọhụrụ ịkọpụta vitamin K1.

Carbamazepine na-abanye n'ime mmiri ara, yabụ uru na mmetụta ndị ọ na-agaghị ekwe omume nke ị breastụ ara kwesịrị iji ya tụnyere usoro ọgwụgwọ na-aga n'ihu. Site n’ịnọgide na-a breastụ ara mgbe ị na-a theụ ọgwụ ahụ, ịkwesịrị igosipụta nlezianya maka nwatakịrị ahụ na o nwere ike ịmalite mmeghachi omume ọjọọ (dịka ọmụmaatụ, ụra miri emi, mmeghachi ahụ anụ ahụ).

Usoro usoro onunu ogwu

N'ime, n'oge nri ma ọ bụ mgbe nri gasịrị, ị drinkingụ ọtụtụ mmiri mmiri.

Maka ịdị mfe iji, mbadamba (yana ọkara ya ma ọ bụ otu ụzọ n'ụzọ anọ) nwere ike etisasị ya na mmiri ma ọ bụ ihe ọ juiceụ juiceụ, ebe ọ bụ na a na-echekwa ihe eji eme ka ogologo oge nke ihe nọ n'ọrụ ka ịhapụsịrị mbadamba ihe ahụ na mmiri. Usoro onunu ogwu eji mee ihe bu 400-1200 mg kwa ubochi, bu ndi ana ekesa ya n’ime 1-2 kwa ubochi.

Ogo kachasị kwa ụbọchị ekwesịghị ịgabiga 1600 mg.

Mgbe ọ bụla enwere ike, ekwesịrị ịkọwa Finlepsin® retard dị ka monotherapy. Ọgwụgwọ na-amalite site n'iji obere ọgwụ kwa ụbọchị, nke na-eji nwayọ nwayọ nwayọ ruo mgbe a ga-enweta nsonaazụ kachasị mma. Agbakwunyere Finlepsin® retard na ọgwụgwọ antiepileptik na-aga n'ihu ka ejiri nwayọ nwayọ mee ya, ebe a naghị agbanwe usoro nke ọgwụ ndị eji eme ihe ma ọ bụ, ọ bụrụ na ọ dị mkpa. Ọ bụrụ na onye ọrịa echefuru ị doseụ ọgwụ ọzọ na oge a, a ga-ewere ọgwụ ahụ echefuara ozugbo ozugbo achọpụtala, ma ị nweghị ike ị takeụ ọgwụ okpukpu abụọ.

Usoro izizi bụ 200-400 mg kwa ụbọchị, mgbe ahụ, a na-eji nwayọọ nwayọọ na-abawanye ọgwụ ruo mgbe a ga-enweta nsonaazụ kachasị mma. Ulo mmezi bu 800-1200 mg kwa ubochi, nke kewara 1-2 na ubochi.

Ọgwụ nke mbụ maka ụmụaka site na afọ 6 ruo 15 bụ 200 mg kwa ụbọchị, mgbe ahụ, a ga-eji nwayọọ nwayọọ mụbaa ọgwụ ahụ site na 100 mg kwa ụbọchị ruo mgbe arụpụtara oke.

Ihe ngosi maka ojiji

Finlepsin ka akwadoro maka ọtụtụ ọrịa gụnyere:

• neuralgia
• Akwụkwụ na-adọ
• ọnọdụ dịgasị iche iche
• ọnọdụ psychotic
• mmanya

Dọkịta na-eme ọkwa otu oge n'ụzọ zuru ezu na ntuziaka na njiri mara ụlọ ọgwụ. Onwe-eze ka eji ọgwụ ike akwadoro.

Ihe ngbanwe

A naghị akwado Finlepsin maka:

• Nkwekorita nke mmadu n’otu n’ime ihe mejuputa ya ma obu imegide atule (tricyclic)
• ojiji nke MAO inhibitors ma ọ bụ nkwadebe lithium
• nsogbu nke ụmị ọkpụkpụ
• Ihe mgbochi AV
• nnukwu porphyria

N'iji nlezianya dị anya, edere mbadamba nkume maka:

• imebi akụrụ, imeju, sistem
• ndị ọrịa agadi
• ịcomụ ọgwụ mgbochi ma ọ bụ ọgwụ ụra
• ubara mgbali (intracranial, intraocular)
• ọrịa prostate
• egbu egbu egbu

Mmetụta akụkụ nke ngwa ahụ Finlepsin nwere ike inye mmebi iwu ọ bụla maka ntuziaka maka iji, dịka ọmụmaatụ, oke nfe. N'ime ụdị dịgasị iche iche, a ga-ahụta ihe ọghọm na arụ ọrụ sistem ma ọ bụ endocrine, yana sistem hematopoietic. Ọ bụrụ na emeghị ihe kwekọrọ na ntuziaka dị na akpa a nwere ike ibute ọ bụghị naanị nsogbu nwa oge na ụdị isi ọwụwa ma ọ bụ ọgbụgbọ, kamakwa ọ bụ nnukwu nsogbu: leukocytosis, leukopenia, wdg.

Finlepsin nwere isi carbamazepine (ihe bụ isi na-arụ ọrụ) yana akụrụngwa inyeaka: magnesium stearate, gelatin, croscarmellose sodium, MCC, wdg Thedị ntọhapụ nke ọgwụ ahụ bụ mbadamba. A na-atụ aro ọgwụ a ka ewere ya naanị dị ka dọkịta si nye ya ma kwekọrọ na ntuziaka ahụ.

Mbadamba Finlepsin: ntuziaka maka ojiji

Finlepsin Mbadamba ụrọ dị ka ntuziaka maka ojiji a ga-esi dị maka nchịkwa ọnụ, na-enweghị aka banyere nri nri. Dabere na ịdị njọ nke ọnọdụ ahụ ma ọ bụ ọrịa na foto zuru oke, enwere ike ịkọwa ndị okenye opekata mpe 200 mg (1 mbadamba, ọgwụgwọ mbụ), ọgwụgwọ mmezi gụnyere ị theụ ọgwụ ahụ na oke ọnụọgụ 800-1200 mg kwa ụbọchị (nkewa n'ime ọtụtụ usoro). Usoro kachasị anabata ị nwere ike ị nweta bụ 1.2-2 g tupu ngwụcha nke usoro ahụ, a ga-eji nwayọ belata usoro ị theụ ọgwụ ahụ. Dịka ntuziaka ahụ si dị, ịkwụsị iwere maka nnabata mbanye nwere ike ibute nsonaazụ na-adịghị mma. Childrenmụaka, na ndabere nke ihe ngosi, a na-atụ aro ka ịmalite ị takingụ ọgwụ ahụ "Finlepsin Igha azu ”na onunu ogwu nke 200 mg (analog).

Ọ nwere ike ị nweta neuralgia?

Finlepsin na - enyere aka na trigeminal neuralgia, mana ụfọdụ ndị ọrịa ekwuola na nke a kpatara enweghị enweghị mmasị, nke butere ibelata nkwukọrịta mmekọrịta. N'ọnọdụ ọ bụla, ọ bụ ọkachamara na-eme nhọpụta ahụ, yabụ, ọ bụrụ na-egosi mmetụta ndị na-adịghị mma (n'akụkụ), ịkwesịrị ịkwụsị ị theụ ọgwụ ma gakwuru dọkịta gị ọzọ.

N’ime ime na ụmụaka nwere ike?

N'ime afọ ime, a na - enye ndị inyom ọgwụ, ọ bụrụ na ọ ga - ekwe omume, monotherapy na usoro opekempe (ọgwụgwọ otu ọgwụ). Nke a na-ebelata ihe ọghọm nke ịmụmụ nwa n’afọ n’afọ. Mkpebi nnabata nnabata ọ bụ naanị dọkịta na-abịa ka ọ kpebiri, na-adabere n'ihe ngosipụta nke onye ọrịa. Egosiputara otu aro a, dika ntuziaka maka ojiji a si puta, ana aputa n’ime oge omumu a.

Ide akwụkwọ akwadoro maka ụmụaka Finlepsin Mbelata (analog) na mbadamba usoro onunu ogwu nke 200 mg:

• Afọ 1-5 - oke onunu ogwu bu 400 mg kwa ubochi (bido iwe, jiri nwayọ na-abawanye ogwu site na 200 rue nari 400 mg egosi)
• 6-10 - kacha nke ubochi kwa 600mg
• Afọ iri na otu n’afọ iri na isii - anakwere 1000 mg kwa ụbọchị

Finlepsin Retard

Dabere na ntuziaka maka ojiji Finlepsin Ha na-amalite were nke oma, were nwayọ na-abawanye ogwu. Usoro onunu ogwu dabere na ihe ngosi a: ogo nke oria, udiri ekpughere ya, nkpu na njiri mara ya. N'ọnọdụ ụfọdụ, enwere ike dochie ya Finlepsin Laghachi na analog, Otú ọ dị, ọ bụ naanị dọkịta nwere ike ime mkpebi dị otú ahụ.

Finlepsin na mmanya dakọtara?

E gosiputara na isi ihe di n’ime ogwu a na –eme ka nsogbu ethanol ghara idi. Agbanyeghị, dị ka ntuziaka maka iji mee ihe, a naghị atụ aro ka ikpokọta mbadamba ihe na iji ihe ọ alcoụholicụ na-egbu egbu - iyi egwu nke nsonaazụ yana oke nsogbu.

Isi analogues nke ọgwụ Finlepsin (mbadamba):

• Carbalepsin Retard (INN)
• Zeptol
• Actinval
• Tegretol
• Zagretol
• Stazepine

Naanị dọkịta na-ahụ maka ịga nwere ike ịkọwa akara ndị ahụ ma kọọkwa analog maka ojiji. Dabere na ntuziaka maka ojiji, njikwa onwe anaghị akwadoro.

Ego ole ka ụlọ ahịa ọgwụ na-eri?

Ọgwụ bụ ọgwụ a na-enye ya ma ọ bụrụ na ọ na-ekesa naanị ya. Ọnụ ego ọgwụ ahụ dị iche n'etiti 200-280 rubles (dabere na usoro onunu ogwu na oke ọgwụ).

Ihe ngosi maka ojiji Finlepsin buru ibu. Ndị ọkachamara na-achọpụta ịdị mma ya n'ịgwọ ọtụtụ ọnọdụ na ọrịa na-agbasochi ndụmọdụ anya, dịka egosipụtara site na nyocha ha dị mma.

Nyochaa nke ndị ọrịa dị oke na nkwubi okwu nke ndị dibịa, mana na mgbakwunye na arụmọrụ, a na-ahụta mmetụta ndị dị ka ọrụ ọgụgụ isi belata, uru na-akwụghị chịm, wdg. N'ọnọdụ ụfọdụ, achọpụtala ndụmọdụ ndị ahụ iji dochie mbadamba nkume na analogues.

Njirimara Finlepsin

Emepụtara na-enye ọgwụ n'ụdị mbadamba nwere 200 mg nke carbamazepine dịka ihe na-arụ ọrụ. Ihe a na - enwe mmetụta n’ahụ mkpụrụ ndụ ụbụrụ, na - egbochi ihe omume na - emetụta akwara. N'ihi nke a, Finlepsin na-enye mmetụta ọgwụgwọ ndị a:

• na anticonvulsant, gụnyere Akwụkwụ na-adọ.
• mgbochi, iwelata nchegbu, iwe iwe, ngosipụta nke ịda mba,
• izizi maka mbufụt nke usoro dị iche iche nke sistem ụjọ, dịka ọmụmaatụ na neuritis.

A na-enyekwa ọgwụ ọgwụ maka ịdị njikere maka ọrịa mbubata, nke mmanya na-egbu egbu na-akpata.

A na-egosi Finlepsin maka ọrịa ndị a:

• Akwụkwụ na-adọ, gụnyere n'ụdị ya dị iche iche,
• Akwụkwụ na-adọ nke na-arịa ọtụtụ ọrịa sclerosis, paresthesia, diazartria na ọrịa ndị ọzọ,
• mgbu na neuritis na mbibi akwara akwara, gụnyere ọrịa shuga na-akpasu iwe,
• neuralgia nke amaghi ebe,
• ọrịa uche, tinyere ndị nsị anụ ahụ na-akpata,
• dị ka akụkụ nke usoro ọgwụgwọ zuru oke nke mgbaàmà ndọrọ ego.

Ogwu nwere otutu contraindications, yabụ i nweghi ike iji ya n’emeghi ndenye dọkịta. Otu n'ime ahụ mmadụ nke na-akwadoghị ya iji Finlepsin bụ hematopoiesis, ngọngọ atrioventricular, porphyria, na ntinye nke ọgwụ.

Na-emegide usoro ọgwụgwọ na Finlepsin, mmepe nke mmeghachi omume na-adịghị mma site na mgbari nri, ụjọ, akwara, endocrine, usoro mkpụrụ ndụ, usoro akwara ahụ, akwara ahụ na imepụta ọbara ga-ekwe omume. Ndepụta nke nsonaazụ dị ogologo. Ọ bụrụ n ’ihe ịrịba ama ọ bụla egosipụtara, kwụsịnụ iburu mbadamba ndị ahụ ma kpọtụrụ dọkịta.

Achọghị Finlepsin ma ọ bụrụ na emebi iwu ọbara, nzụlite nke ihe atụ, porphyria, nnabata nke ọgwụ niile.

Ntụnyere Ọgwụ

Ogwu di otua n'uzo otutu, mana enwere odi iche.

Nkwadebe ahụ nwere otu ụdị ihe eji arụ ọrụ, nwere otu ihe eji arụ ọrụ. Anaghị akwadoro maka iji ya mee otu ọnọdụ ahụ ike yana ahụike nke ahụ. Nsonaazụ ndị ọ na-ebute site na ọgwụ na-emetụtakwa.

A na-emepụta ọgwụ site na otu onye nrụpụta - ụlọ ọrụ transatlantic Teva. A ga-enye ọgwụ abụọ a na ndenye ọgwụ.

Kedu ihe dị iche?

Finlepsin retard dị iche na onye buru ya ụzọ na ọrụ ogologo oge. N'otu oge, ahụ, a na-ahapụ ngwa ya, nke na-eme ka ịhapụ ọgwụ dị ogologo oge. Nke a na - emetụta nsonaazụ - ọghọm nke ihe ha na - ebelata.

Finlepsin retard na-akpata ọtụtụ mmetụta dị iche iche, gụnyere ọgbụgbọ, ọgbụgbọ, ura, nchepụta echiche, na nsogbu ọhụụ.

Nyocha nyocha Ndidi

Marina, onye dị afọ 27, Ryazan: “Aghaghị m izute Finlepsin mgbe nna nwunye m merụrụ ahụ. Ọ bụghị Akwụkwụ na-adọ, kama ọ yiri nke ahụ. Dọkịta depụtara ọgwụ a, na-ekwu na ọ bụghị naanị ndị ọrịa na-arịa ọria, kamakwa ndị nwere nnukwu nkwarụ na-eji ya. Nwunye nna bidoro ị pụ ọgwụ, kama ọ malitere ime mkpesa nke ure na uju. Aghaghị m ịlaghachi na dọkịta nke nyere Finlepsin retard ọgwụ. Papa m na-anabata ọgwụ ndị a nke ọma. ”

Irina, onye dị afọ 41, Voronezh: “Edere Finlepsin di ya ka ọria ọbara na-efe efe. Di na nwunye na-a takesụ ọgwụ maka ọnwa nke abụọ. Ọ naghị eme mkpesa banyere nsonaazụ ndị ọ na-akpata. Ahụ́ adịghị onye ọ bụla ma ọ bụ di ya, dọkịta ahụ na-ekwupụta na ọgwụgwọ ọ rụpụtara bụ ihe dị mma. ”

Ndị dọkịta na-atụle Finlepsin na Finlepsin retard

Igor, onye na-ahụ maka ọgwụgwọ, dị afọ 45, Nizhny Novgorod: “Ọgwụ abụọ ahụ dị irè, ndị ọrịa na-anabata ya nke ọma. Ọnụ ahịa dị ọnụ. ”

Vladimir, ọkachamara n'ihe banyere akwara ozi, onye dị afọ 51, Bryansk: “Dabere na ọrịa ahụ na ọnọdụ ahụike nke onye ọrịa, ana m ekwupụta Finlepsin ma ọ bụ nkọwa ya nke ogologo oge. Ekwere m na ọgwụ abụọ ahụ dị irè. Mmetụta ọghọm dị, mana ọ na-esiri ike, ma ọ bụrụ na onye ọrịa ahụ ekwenye n'ihe ndị dọkịta kwuru. Ihe mgbakwunye bụ ọnụ ahịa ọgwụ: ọ fọrọ nke nta ka ọ bụrụ onye ọ bụla. ”