Tujo SoloStar - ntụziaka maka ojiji > Ọgwụgwọ na mgbochi

Mlọ ọgwụ
Ihe kachasị mkpa nke insulin, gụnyere insulin glargine, bụ reflux nke metabolism metabolism. Insulin na anaakpo ya na –ebelata nnabata nke glucose n’ime ọbara, na - akpali nnabata nke glucose site na uru anụ ahụ (ọkachasị akwara na akwara adi adi) ma na - egbochi imeju glucose na umeji. Insulin na - egbochi lipolysis na adipocytes (sel abụba) ma na - egbochi protein, ebe yana ịba ụba protein.
Atụmatụ ọgwụ
Insulin glargine bu ihe nlele nke insulin nke mmadu nwetara site na ntughari nke DNA nke nje na ndu Escherichia coli A na - ejikwa eriri K12 eme ihe. Ọ nwere solubility dị ala na gburugburu ebe anaghị anọpụ iche. Na pH 4 (na gburugburu acidic), insulin glargine bụ mmiri mmiri nwere mmiri kpamkpam. Mgbe iwebata na abụba subcutaneous, a na-adọghachi mmeghachi omume acidic nke ihe ngwọta, nke na-eduga na ịmalite microprecipitate, site na nke obere gulingine na-ewepụta oge niile.
Nmalite nke insulinaneously injection insulin glargine 100ED / ml dị nwayọ ma e jiri ya tụnyere insulin nke mmadụ, usoro ya dị mma ma na-enweghị ọnụ ọgụgụ dị elu, oge ọ gbatịkwara. (Data sitere na ọmụmụ nyocha ngwa ngwa ndị e mere na ndị ọrụ afọ ofufo dị mma na ndị ọrịa nwere shuga. ụdị shuga 1).
Mmetụta hypoglycemic nke nkwadebe Tujeo SoloStar® mgbe ọ nwesịrị nchịkwa subcutaneous, ma e jiri ya tụnyere nke a na nchịkwa insulin glargine 100 IU / ml, nọgidesiri ike na ịdị ogologo ma na-agbatịkwu (data sitere na nyocha elekere 36-euglycemic clamp na-eme na 18 ndị ọrịa shuga. ụdị shuga 1). Omume nke ọgwụ Tujeo SoloStar® were ihe karịrị awa 24 (ruo awa 36) na nchịkwa subcutaneous ya na usoro ọgwụgwọ dị egwu (lee ọgụgụ dị n'okpuru).

Mmetụta hypoglycemic ogologo oge nke nkwadebe Tujeo SoloStar®, na-adịgide karịa awa 24, na-enye ohere, ma ọ bụrụ na ọ dị mkpa, na-agbanwe oge nchịkwa nke ọgwụ ahụ n'ime awa 3 tupu ma ọ bụ awa 3 mgbe oge ịgba ọgwụ na-abịakarị onye ọrịa ahụ (lee akụkụ "Usoro nchịkwa na usoro onunu ogwu").
Esemokwu dị na akụkụ nke ụzọ hypoglycemic mmetụta nke Tujeo SoloStar® na insulin glargine 100 IU / ml jikọtara ya na mgbanwe na mwepụta insulin glargin site na mkpali.
Maka otu ọnụego insulin glargine dị, olu a na-ahụ maka nkwadebe Tujeo SoloStar® bụ otu ụzọ n'ụzọ atọ nke mgbe ị na-elekọta insulin glargine 100 IU / ml. Nke a na-eduga na mbelata nke mpaghara ugwu ahụ, nke na-eme ka mpụta nke insulin glargine nwayọ nwayọ site na mkpali maka nkwadebe Tujeo SoloStar®, ma e jiri ya tụnyere insulin na-akpali glargine 100 IU / ml.
Mgbe emere otu insulin glargine na insulin ahụ mmadụ na-eme intraven, mmetụta hypoglycemic ha bụ otu.
Icationgwa ndị na - anabata insulin okwu: insulin glargine bụ metabolized abụọ metabolites na-arụ ọrụ, Ml na M2 (lee ngalaba Pharmacokinetics). Nchoputa in vitro gosiri na ogo insulin glargine na metabolites ya nke Ml na M2 maka ndị na - anabata insulin na - anabata ya.
Nkwukọrịta n'etiti ndị na - anabata insulin na - eto uto (IGF-1):
ịdị ọcha nke insulin glengine maka ihe nnabata nke IGF-1 bụ ihe dị ka okpukpu 5-8 karịa nke insulin mmadụ (mana ihe dị ka ugboro 70-80 dị ala karịa nke IFR-1), ebe insulin metabolites na-atụnyere insulin mmadụ. glargine Ml na M2 nwere obere mmekọrịta dị mma maka ihe nnabata nke IGF-1 ma e jiri ya tụnyere insulin mmadụ. Nchikota ọgwụgwọ insulin (ịta insulin glargine na metabolites ya), kpebisiri ike na ndị ọrịa nwere ụdị ọrịa shuga 1 dị obere, tụmadị dị ala karịa mkpakọ a chọrọ maka ntinye nke ọkara nke ndị na-anabata ndị IGF-1 na ntinye nke ụzọ mitogenic proliferative na-akpata site na ndị na-anabata IGF-1. . Ihe omumu nke physiological nke IGF-1 nwere ike ime ka uzo omitogenic proliferative rụọ ọrụ, agbanyeghị, usoro ọgwụgwọ insulin na-ekpebi n'oge ọgwụgwọ insulin, gụnyere ọgwụgwọ ya na Tujeo SoloStar®, dịkarịsịrị ala karịa ọnụ ọgụgụ ọgwụ ọgwụ achọrọ iji rụọ ọrụ mitogenic proliferative way.
Nsonaazụ enwetara na ule nyocha niile nke Tujeo SoloStar® nke emere ndị ọrịa 546 nwere ọrịa shuga 1 na ndị ọrịa 2474 nwere ụdị 2 gosipụtara mbelata nke ọbara haemoglobin (HbAlc) na-emetụta. ụkpụrụ, site na njedebe nke ọmụmụ ahụ erughị nke ahụ na ọgwụgwọ insulin glargine 100 IU / ml.
Ọnụ ọgụgụ ndị ọrịa ruru mgbaru ọsọ HbAlc (nke dị n'okpuru 7%) yiriri iche na otu ọgwụgwọ abụọ.
Mbelata nke mgbanye glucose plasma na ngwụsị nke ọmụmụ ya na Tujeo SoloStar® na insulin glargine 100 IU / ml bụ otu, mana n'otu oge ahụ, site na iji ọgwụgwọ na Tujeo SoloStar®, mbelata nke a bịara nwayọọ nwayọọ karịa mgbe a na-ahọrọ ya.
N'ime ndị ọrịa mesoro Tujeo SoloStar®, ka ọ na-erule ngwụsị nke usoro ọgwụgwọ ọnwa 6, achọpụtala ịdị elu nke na-erughị 1 n'arọ.
Ọganiihu na HbAlc nọọrọ onwe ya na okike, agbụrụ, afọ, ogologo oge nke ọrịa mellitus, HbAlc, ma ọ bụ ndekọ ahụ mmadụ (BMI) na nsonaazụ.
N'ime ndị ọrịa nwere ụdị ọrịa shuga abụọ nke ọrịa mellitus, nsonaazụ nke ọmụmụ ụlọ ọgwụ gosipụtara ọnọdụ dị ala nke ọrịa siri ike na / ma ọ bụ gosipụtara hypoglycemia, yana edepụtara hypoglycemia nwere akara ọrịa, mgbe ejiri ya na Tujeo SoloStar®, ma e jiri ya tụnyere insulin glargine 100 U / ml.
E gosipụtara uru nke Tujeo SoloStar® karịa insulin glargine 100 IU / ml iji belata ihe ize ndụ nke ịmalite ọrịa siri ike na / ma ọ bụ gosipụtara hypoglycemia nocturnal gosipụtara na ndị ọrịa natara ọgwụ nje hypoglycemic ọnụ (mbelata 23% n'ihe ize ndụ) ma ọ bụ insulin nwere nri (mbelata 21% n'ihe ize ndụ ) oge site na izu 9 ruo na njedebe nke ọmụmụ ahụ, ma e jiri ya tụnyere ọgwụgwọ glargine insulin na 100 PIECES / ml.
N'ime ìgwè ndị ọrịa mesoro Tujeo SoloStar®, e jiri ya tụnyere ndị ọrịa e mesoro insulin glargine 100 U / ml, a hụrụ mbelata ihe ọghọm hypoglycemia, na ndị ọrịa nwetagoro ọgwụgwọ insulin na ndị ọrịa enwetabeghị insulin, mbelata ihe egwu dị ukwuu karịa n’ime izu asatọ mbụ nke ọgwụgwọ (usoro ọgwụgwọ izizi) na esiteghị na afọ, okike, agbụrụ, ntụpọ nke anụ ahụ (IM G), yana oge ọrịa shuga mellitus (> afọ 10).
N'ime ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 1, ọrịa nke hypoglycemia n'oge ọgwụgwọ Tujeo SoloStar® yiri nke ahụ na ndị ọrịa mesoro insulin glargine 100 U / ml. Agbanyeghị, ọnọdụ nke hypoglycemia nke nocturnal (maka ụdị hypoglycemia niile) n'oge usoro ọgwụgwọ dị ala dị ala na ndị ọrịa e mesoro Tujeo SoloStar® ma e jiri ya tụnyere ndị ọrịa mesoro insulin glargine 100 U / ml.
N’ime ule dị iche iche, otu nchịkwa nke Tujeo SoloStar® n’ehihie nwere usoro nchịkwa ahazi (n’otu oge) ma ọ bụ nhazi nhazi mgbanwe (ọ dịkarịa ala ugboro abụọ n’izu, ka a na-a theụ ọgwụ ahụ awa 3 tupu ma ọ bụ awa 3 mgbe oge nkịtị gasịrị nchịkwa, n'ihi nke a na-eme ka oge dị n’etiti nchịkwa dị ka awa 18 ma gbatịkwuo ruo awa 30) na-enwe otu arụmọrụ na ndeki HbAlc, na-ebu ọnụ plasma glucose (GPC) na nkezi uru nke njedebe tupu ịgba ntụtụ. ịchọpụta glucose na plasma ọbara n’oge mkpebi onwe gị. Na mgbakwunye, mgbe ị na-eji Tujeo SoloStar® na usoro oge a kapịrị ọnụ ma ọ bụ nke na-agbanwe agbanwe, enweghị ọdịiche ọ bụla na hypoglycemia n'oge ọ bụla n'ehihie ma ọ bụ n'abalị hypoglycemia. Nsonaazụ nke ọmụmụ atụnyere Tujeo SoloStar® na insulin glargine 100 IU / ml egosighi ọnụnọ nke ọdịiche ọ bụla na arụmọrụ, nchekwa ma ọ bụ nke insulin basal metụtara njikọ nke ọgwụ mgbochi ọrịa na insulin n'etiti ndị ọrịa mesoro Tujeo SoloStar® na insulin. Glargine 100 PIECES / ml (lee mpaghara “Side side”).
N'ime mba ụwa, ọmụmụ ihe, usoro nyocha, ORIGIN (Mbelata nsonaazụ ya na mbido Glargine INtervention), gụnyere ndị ọrịa 12537 nwere nsogbu glycemia (HH), ọrịa glucose na-arịa ọrịa (NTG) ma ọ bụ mmalite mbido ọrịa shuga 2 na ọrịa obi. na insulin glargine ọgwụgwọ na 100 PIECES / ml, ma e jiri ya tụnyere usoro ọgwụgwọ hypoglycemic ọkọlọtọ, agbanweghị ihe ize ndụ nke ịmalite nsogbu obi (ọnwụ obi, infarction myocardial na-adịghị egbu egbu) ma ọ bụ nke na-adịghị egbu egbu. ọnya ọnya, ihe ọghọm nke usoro ịmụgharị (akwara, carotid ma ọ bụ akụkụ akwara) ma ọ bụ ihe ize ndụ nke ụlọ ọgwụ maka mmepe nke obi obi ihe isi ike na - akpata nsogbu microvaskụla (ihe njikọtara nke nsogbu microvascular: laser photocoagulation ma ọ bụ vitrectomy, nhụhụhụhụhụhụ n'anya n'ihi ọrịa mamịrị retinopathy, ọganihu nke albuminuria. , ma ọ bụ obi abụọ nke itinye uche na ọbara n'ọbara, ma ọ bụ ihe omume nke chọrọ ọgwụgwọ ọgwụgwọ).
N'ime ọmụmụ nyocha na-atụle nsonaazụ insulin glargine 100 IU / ml na mmepe nke ọrịa mamịrị retinopathy n'oge afọ ise nke ndị ọrịa nwere ọrịa shuga 2, enweghị nnukwu ọdịiche na nzaghachi npoi nke ọrịa mamị retinopathy mgbe ị na-agwọ insulin glargine 100 IU / ml, ma e jiri ya tụnyere insulin isofan.
Ndị otu ọrịa pụrụ iche
Okike na agbụrụ
Enweghị ọdịiche dị iche na arụmọrụ yana nchekwa nke Tujeo SoloStar® na insulin glargine 100 IU / ml dabere na okike na agbụrụ ndị ọrịa.
Ndị okenye na-arịa ọrịa
N'ime ule ụlọ ọgwụ a na-achịkwa, ndị ọrịa 716 (23% nke ndị bi na nyocha maka nchekwa) na ụdị 1 na ụdị ọrịa shuga 2 dị afọ> 65 afọ na ndị ọrịa 97 (3%) agadi> afọ 75. Na mkpokọta, enweghị ọdịiche na ịdị mma nke nchekwa ọgwụ dị n'etiti ndị ọrịa a na ndị ọrịa nke okenye. N'ime ndị ọrịa agadi nwere ọrịa mellitus, iji zere mmeghachi omume hypoglycemic, usoro izizi na usoro mmezi kwesịrị ịdị ntakịrị, mmụba nke dose kwesịrị iji nwayọọ. O nwere ike isiri ndi agadi ọrịa ike ịmata hypoglycemia. A na-atụ aro iji nlezianya na-etinye nlebara mgbanye glucose ọbara, yana ịkwesịrị ịhazigharị insulin n'otu n'otu (lee mpaghara "Usoro Ọgwụ na Nchịkwa" na "Pharmacokinetics").
Ọrịa enweghị akụrụ
N'ime ule ụlọ ọgwụ a na-achịkwa, nyocha nke obere na-adabere na ọnọdụ akụrụ arụrụ arụmọrụ (kpebisiri ike site na nsonaazụ mpịakọta glopsular> 60 ml / min / 1.73 m nke anụ ahụ) egosighi ọdịiche n'ihe nchekwa yana ịdị mma n'etiti Tujeo SoloStar® na insulin glargine 100 U / ml A na-atụ aro iji nlezianya na-eleba anya itinye glucose ọbara, yana nhazigharị nke insulin n'otu n'otu (lee "Usoro Ọgwụ na Nchịkwa" na "Pharmacokinetics").
Ndị ọrịa Obese
N'ime ihe omumu ihe omumu, nyocha ihe omumu nke dabere na aru mmadu (BMI) (ihe ruru 63 n'arọ / m 2) egosiputaghi odighi iche na odi nma na nchekwa n’etiti Tujeo SoloStar® na insulin glargine 100 IU / ml.
Ọrịa ụmụaka
Enweghị data maka ojiji Tujo SoloStar® nke ọgwụ na ụmụaka.
Mlọ ọgwụ
Ndopu na nkesa
Mgbe onye ọrịa afọ ofufo na Tujeo SoloStar® butere ụzọ, nweekwa ahụ ike na-arịa ọrịa shuga, mkpo insulin na-egosi nwayọ nwayọ na ogologo oge, nke na-eduga n'ịdị nwayọ nwayọ oge ruo awa iri atọ na isii, ma e jiri ya tụnyere insulin glargine. 100 PIECES / ml. Oge ntinye uche nke Tujeo SoloStar® kwekọrọ na usoro ọrụ ọrụ ya. Enwetara ịha nha n ’ọnọdụ ịta ahụ wee rụpụta ụbọchị 3-4 n’ime ọgwụ Tujo SoloStar® kwa ụbọchị.
Mgbe agwara Tujeo SoloStar® subcutaneous, mgbanwe dị na otu onye ọrịa ahụ, akọwapụtara dị ka ọnụọgụ nke mgbanwe nke sistemụ insulin na elekere 24 n'ime ọnọdụ ịbịanye uche, dị ala (17.4%).
Metabolism
N'ime ụmụ mmadụ, mgbe ọchịchị nchịkọtara nke Tujeo SoloStar® gasịrị, a na-ahụzi insulin glargine ngwa ngwa site na carbonxyl end (C-terminus) nke P yinye iji mepụta metabolites abụọ na-arụ ọrụ Ml (21A-Gly-insulin) na M2 (21 A-Gly-des-30B-) Thr-insulin). Ọ na-abụkarị ndị metabolite Ml na-ebugharị na plasma ọbara. Ihe ngosiputa nke usoro Ml metabolite na-abawanye site na ịba ụba nke ọgwụ Tujeo SoloStar®. Njikere nke pharmacokinetics na data pharmacodynamics gosiri na mmetụta nke ọgwụ ahụ bụ nke kachasị site na ikpughe sistemu nke Ml metabolite. N'ime ọtụtụ ndị ọrịa, enweghị ike ịchọpụta insulin glargine na metabolite M2 n'usoro sistem. N'ọnọdụ ebe ọ ka nwere ike ịchọpụta insulin glargine na metabolite M2 dị n'ọbara, ihe ndị ha na-eme dabere adabereghị na usoro a na-enye insulin glargine.
Ojiji
Ọkara ndụ nke metabolite Ml, nke metabolites buru ibu nke ọgwụ Tujo SoloStar®, mgbe ọ gbasịrị ọgwụ ọgwụ subcutaneous bụ awa iri na asatọ ruo awa iri na asatọ ruo na agbanyeghị ole ọ dị.
Ewoootu ọrịa dị iche iche
Afọ na okike
Enweghị ihe omuma banyere agbụrụ na okike na pharmacokinetics nke insulin glargine (lee ngalaba nke Pharmacodynamics).
Ndị okenye na-arịa ọrịa
Amụtabeghị nsonye afọ dị iche iche na pharmacokinetics nke Tujeo SoloStar®. N'ime ndị ọrịa agadi nwere ọrịa mellitus, iji zere mmeghachi omume hypoglycemic, usoro izizi na usoro mmezi kwesịrị ịdị ntakịrị, yana mmụba nke dose kwesịrị iji nwayọọ (lee akụkụ "Pharmacodynamics" na "Usoro onunu ogwu na nchịkwa").
Childrenmụaka
N'ime ndị ọrịa ụmụaka, agụbeghị ọgwụ ọgwụ Tujeo SoloStar®.
Ọrịa enweghị nsogbu gbasara akwara na hepatic
Emebeghị ka omumu ihe gbasara akuko na enweghi nsogbu nke onodu ogwu eme ihe banyere Tujo SoloStar®. Ka osi di, ihe omumu emere na insulin mmadu gosiputara onu ogugu insulin na ndi oria na aru ya na hepatic. A na-atụ aro iji nlezianya leba anya ịbawanye glucose ọbara na ịhazigharị kwa insulin (lee akụkụ "Usoro Ọgwụ na Nchịkwa" na "Ntuziaka Pụrụ Iche").

Ihe ngbanwe

N'ime ụmụ nwanyị dị ime (enwere ike ịgbanwe mkpa nke insulin n'oge ime na mgbe amuchara nwa), ndị ọrịa agadi (leengalaba "Pharmacokinetics", "Pharmacodynamics", "Usoro onunu ogwu na nchịkwa" na "Ntuziaka Pụrụ Iche"), ndị ọrịa nwere nsogbu ọgwụgwụ endocrine (dịka hypothyroidism, ezughi oke nke adenohypophysis na adrenal cortex), ya na ọrịa ndị ọ na-esite na vomiting ma ọ bụ afọ ọsịsa, ya na nnukwu stenosis akwara ọbara na akwara ma ọ bụ arịa ụbụrụ, nwere ọrịa retinopathy na-abawanye uru (ọkachasị ma ọ bụrụ na e kwughi ndị ọrịa), yana ọrịa akụrụ, nwere nnukwu akwara (lee ngalaba "Iwu Pụrụ Iche" Ania ”)

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

A na-enweta ya n’ụdị edozi doro anya maka ịgba ntụtụ n’ụdị sirinji 1.5 ml na olu (ihe ruru pcs ise. N’otu kaadiboodu).

1 ml nke ọgwụ nwere:

300 ihe eji eme insulin glargine,
metacresol
zinc chloride
85% glycerin,
sodium hydroxide
hydrochloric acid,
mmiri maka ịgba ntụtụ.

Omume ọgwụ

Insulin na-arụ ọrụ ogologo oge nke na-edozi metabolism nke glucose. Mgbe o riri, anụ ahụ na - akpali akpali ịbanye glucose, na - egbochi ya na imeju ma belata mkpụkọ. Ọzọkwa, a na-eme ka njikọ protein.

Glargin na-aru oru dika insulin nke mmadu. Oge ekpughere site na awa 24 ruo 36 - dabere na ọnụnọ arụ na ihe ndị ọzọ metụtara ya. N'adịghị ala, ọ na-akpata hypoglycemia ma e jiri ya tụnyere ndị ọgbọ, gụnyere n'abalị. Fọrọ nke nta enweghị mmetụta na mgbanwe n’arụ ahụ, mana ọ chọrọ ezigbo nri.

Mlọ ọgwụ

Mgbe nchịkwa subcutaneous gasịrị, nnabata nwayọ nwayọ, ogologo oge, ma gbasaa n ’otu ahụ. Ihikota ịha nha bụ 3-4 ụbọchị mgbe ejiri ya kwa ụbọchị.

Insdị insulin a na-agbakọ ngwa ngwa na ahụ: ọkara ndụ nke awa 18-19.

Enweghị mmetụta nke afọ na okike na arụmọrụ nke glargine, mana ekwesịrị ịnye ndị okenye ihe nrịbama ma mụbaa nwayọ ma zie ezie.

1dị 1 na ụdị ọrịa shuga 2 n'ime ndị okenye.

Ntụziaka maka ojiji (usoro)

Ọ bụ dọkịta na-ahụ maka ya depụtara ya iche. Ọ dabere na ahụ́ gị chọrọ glucose. A na-ekpebi ajụjụ nke dose ahụ dabere na data nyocha ndị ọrịa. A na-eme ọgwụ mgbochi otu oge n'otu oge n'ụbọchị.

IKWU! Naanị subcutaneous injections na-ekwe!

Y’oburu na ogwu akpachapuru anya, yabụ n’enweghi ike inyere ogwu a okpukpu abuo! Naanị ịchọrọ inyocha ọbara maka ịta shuga ma laghachi n'ọchịchị na-emebu site na inyocha ọnọdụ ahụ.

Site n'ọrịa shuga nke 1, a na-eji ya na insulin eme ngwa ngwa iji kpuchie mkpa maka ya na nri.

Na ụdị ọrịa shuga 2, a na-ejikọ ya na ọgwụ hypoglycemic ndị ọzọ.

Ngwọta ahụ kwesịrị ịdị n ’ụlọ dị n’ ụlọ ahụ, ebe ntụtụ - afọ, hips na ubu. Ekwesịrị ịgbanwe ọnọdụ nsị ahụ mgbe niile iji wepụ ihe ize ndụ nke lipodystrophy.

Nsonaazụ

Hypoglycemia.
Lipodystrophy.
Mmeghachi omume nfụkasị ahụ.
Mmeghachi omume na saịtị ịgba ama (itching, redness, swelling)
Retinopathy
Uwe.
Myalgia.
Ọgba aghara digestive.

Udiri oria a na-enweta site na ndozi onunu ogwu ma obu iwepu ọgwụ.

Dodoụbiga ya ókè

Ọ bụrụ na dose ahụ buru oke ibu, hypoglycemia nwere ike ịmalite. Ihe mgbaàmà ya bụ adịghị ike, ọgbụgbọ na ọgbụgbọ, nsụhọ mmụọ, ruo ọnwụ nke mmụọ na mmepe nke coma.

A na-eme ka obere hypoglycemia kwụsịlata site na iri nri ndị nwere carbohydrate. A na-ewepụ oge dị nfe na nke siri ike site na ntụtụ nke glucagon ma ọ bụ usoro dextrose, na-esochi ụlọ ọgwụ. N'ọnọdụ ọ bụla, achọrọ mgbanwe insulin usoro onunu ogwu.

Mkparịta ụka ọgwụ ọjọọ

Nke pụtara na kwalite ọrụ insulin glargine:

ndị na-arịa ọrịa hypoglycemic onu
Ihe mgbochi ACE na MAO,
ndị na-enupụ isi
fibrates
fluoxetine
pentoxifylline
propoxyphene
salicylates,
ọgwụ mgbochi sulfonamide.

Ọgwụ ndị na-ebelata ihe ọ na-akpata:

glucocorticosteroids,
danazol
diazoxide
diuretics
glucagon,
isoniazid
estrogens na progestogens,
ntụpọ phenothiazine,
somatropin,
nnabata ọmiko
homonụ thyroid,
ọgwụ ọgwọga na - enweghị ọnya,
ndị na-egbochi ya.

Ihe ndi n’enye otutu nsogbu mgbe ejikọtara ọnụ:

Ọgwụ ndị na-ekpuchi ihe mgbaàmà hypoglycemia:

ihe mgbochi beta,
clonidine
guanethidine,
reserpine.

Ntụziaka pụrụ iche

Iji nlezianya debe ya:

ndị nne dị ime na ndị na-enye nwa ara
ndị okenye
ya na imeju na akụrụ dara,
na-arịa ọrịa endocrine na stenosis nke akwara ọbara ma ọ bụ arịa nke ụbụrụ,
ndị ọrịa nwere ọrịa retinopathy.

Adabaraghị maka ọgwụgwọ nke ketoacidosis na mkpo na mkpochapu sitere na hypoglycemic coma.

Ọrịa anaghị achọ insulin ala obere adabaghị adaba mgbe niile. Dose ukpụhọde chọrọ.

Mgbe ị na-anya ụgbọ ala, ekwesịrị ịkpachara anya, ebe enwere nnukwu hypoglycemia. Ọ kachasị mma ịjụ ịnya ụgbọ ala n'oge ọgwụgwọ niile.

A na-ewepụta ya naanị na ndenye ọgwụ.

Tụnyere ihe analogues

Tujeo Solostar dị iche na nhazi insulin ndị ọzọ na akụrụngwa ya. E gosipụtara ọdịiche na analogues na-ejikarị na tebụl.

Aha, ihe eji arụ ọrụ	Emeputa	Uru na ọghọm ya	Ọnụahịa, tee.
Lantus insulin glargine	Sanofi-Aventis, Germany	Pros: enwere ike inye ọgwụ maka ụmụaka site na afọ isii. Cons: ịta dị ala nke ihe na-arụ ọrụ, mmetụta ahụ na-akwụsị ngwa ngwa.	Igwe eji sirinji 3700/5 nke 3 ml
Levemir, insulin detemir	Novo Nordisk, Denmark.	Uru: nke kwesịrị ekwesị maka ndị inyom dị ime na ụmụaka dị site na afọ isii, ma ọ nwere usoro iji dozie ya. Cons: irè n'ihi na ọ dịghị ihe karịrị otu ụbọchị.	Site na pensụ 2800/5 nke 3 ml
Tresiba, degludec	Novo Nordisk, Denmark.	Uru: dị irè ruo awa iri anọ na anọ. O kwere omume ụmụaka site na otu afọ. Cons: dị oke ọnụ, ọ bụghị mgbe niile na ụlọ ahịa ọgwụ.	Site na 7600

Ojiji nke insulin ozo kwesiri idi n’okpuru oru nke endocrinologist. Amachibidoro ị -ụ onwe gị ọgwụ!

Na mkpokọta, akụrụngwa eji amata nzaghachi dị mma sitere na ndị ọrịa mamịrị nwere ahụmịhe, ọkachasị ma e jiri ya na ọgwụ ndị ọzọ.

Olga: “Malite mgbe m dị afọ 19, arịawo m ọrịa shuga, anwalewo m ọtụtụ ọgwụ dị iche iche. Na mbu, adara Lantus, ma ha kwụsịrị itinye ya na uru. Nyefee ya na Tujeo. Agaghị m ahụkarị ya, mana dọkịta na-adụ gị ọdụ ka ị soro rie obere carb nri. Enwere m olileanya na ihe niile ga-adị mma. N'ime nke ndị ahụ, achọpụtara m na ogologo ya mmetụta dị mma. ”

Victor: “insulin“ Tujeo ”nwere ihe karịrị“ Lantus ”, yabụ m jiri ya mee ogologo oge. Mana n’ozuzu, enwere m shuga na-akwụsi ike, na-enweghị mmiri ọ bụla. M soro nri ma nye gị ndụmọdụ, mgbe ahụ agaghị enwe nsogbu ọ bụla. ”

Anastasia: “Enwere m mmasị na Tujeo karịa Levemir, nke m nọrọ na ihe dị ka otu afọ. Ọ na-ejide shuga nke ọ na-arahụ ụra - nke a ka m na-ebili. Enweghị ọgụ ọgụ hypoglycemia n'abalị. Ma nke kachasị - ọ dịkwa mma iji, a na-enyekwa ya maka uru na ụlọ ahịa ọgwụ. ”

Anna: “Ana m eji Lantus eme ihe. Oge ikpeazu ha nyere Tujeo n’ụlọ ahịa ọgwụ, mgbe ọ kpọchara dọkịta, o kpebiri ịnwale ya. Emegoro m ọgwụ mbụ, yana ọgwụ Humalog, m na-eji ya. Mgbe anwalechara ubochi ato, a choputara usoro ogwu kwesiri ekwesi, ugbu a, m rube isi na ya. Insulin nkịtị na-amasị m, enweghị mkpesa ọ bụla. ”

Dmitry: “Adị m afọ 23, m na-agbabu Lantus. Dọkịta ahụ tụgharịrị na Tujeo nwa oge, enweghị m mmasị na ya. Sugar malitere ịwụ elu nke ọma, aghaghị m iji Novorapid. Mgbe ọnwa otu mmekpa ahụ gasịrị, ọ laghachiri Lantus. Ọgwụ a amachaghị m ma ọlị. ”

Mmechi

Dịka ị pụrụ ịhụ, Tujeo Solostar nwere ma uru ma ọghọm. N’ịhọrọ ọgwụ dị mma na usoro ọ ga-a ,ụ, ndụ ndị ọrịa mamịrị na -akwu mma. Ya mere, ndị ọkachamara ji oke akpọrọ insulins ogologo oge ma dezie ha. Nyocha nke ọgwụ a gosipụtara na ọ dị mma maka ọtụtụ ndị ọrịa nwere ọrịa shuga.

Usoro onunu ogwu na nhazi

Nkwado izugbe
Ngalaba nke Tujeo SoloStar® (insulin glargine 300 IU / ml) na-ezo aka naanị Tujeo SoloStar®, ha ahaghịkwa na nkeji ndị ọzọ na-egosipụta ike nke ọrụ nke analogues insulin ndị ọzọ. Ekwesịrị iji nwayọọ nwayọọ na-achịkwa Tugeo SoloStar® otu ugboro n'ụbọchị n'oge ọ bụla n'ụbọchị, ọkacha mma n'otu oge ahụ. Ọgwụ Tujeo SoloStar® nke nwere otu ntụtụ n'oge ụbọchị na-enye gị ohere ịnwe usoro mgbanwe maka irigha: ọ bụrụ na ọ dị mkpa, ndị ọrịa nwere ike ịgbanye n'ime awa 3 tupu ma ọ bụ awa 3 mgbe oge ha gasịrị.
Ekwesịrị ikpebi ma gbadoro mgbanye mgbanye glucose ọbara, oge na oge nchịkwa / nchịkwa nke ọgwụ hypoglycemic n'otu n'otu.
Enwere ike ịchọ mgbazigharị dose, dịka ọmụmaatụ, site na ịgbanwe ahụ onye ọrịa, ibi ndụ ya, ịgbanwe oge nlekọta insulin, ma ọ bụ n'ọnọdụ ndị ọzọ nwere ike ịbawanye atụmanya na mmepe hypo-ma ọ bụ hyperglycemia (lee mpaghara “Ntuziaka Pụrụ Iche”). Mgbanwe ọ bụla na dose insulin kwesịrị iji nlezianya rụọ ya naanị ma ọ bụrụ na nlekọta nlekọta ahụike.
Tujeo SoloStar® abụghị insulin nke ịhọrọ maka ọgwụgwọ nke ketoacidosis na-arịa ọrịa shuga. N'okwu a, ekwesịrị inye nlekọta intulin na-eme obere mkpali.
N'ime ndị ọrịa niile nwere ọrịa shuga, a na-atụ aro ka nyochaa nke glucose n'ọbara.
Mmalite ị useụ ọgwụ Tujo SoloStar®
1dị Ndị Ọrịa Shuga
Ekwesịrị iji Tujeo SoloStar® otu ugboro n'ụbọchị yana insulin, nke a na-ahazi n'oge nri, yana ịchọrọ nhazi nke otu onye.
2dị Ndị Ọrịa Shuga 2
Usoro akwadoro nke mbụ bụ 0.2 U / n'arọ nke ịdị ahụ otu ugboro n'ụbọchị, na-esote mmezi nke otu.
Ntughari site na nchịkwa insulin glargine 100 IU / ml na ọgwụ Tujeo SoloStar® na, ọzọ, site na ọgwụ Tujeo SoloStar® ruo insulin glargin 100 IU / ml.
Insulin glargine 100 IU / ml na Tujeo SoloStar® ezughị oke na njikwa ọgwụ, njirimara nke ọgwụ na mmetụta nke ụlọ ọgwụ. N'akụkụ a, ntụgharị site na insulin glargine 100 IU / ml gaa ọgwụ Tujo SoloStar® na nke ọzọ, chọrọ nlekọta nke dọkịta, nlezianya na-achịkwa metabolic na mmezi nke ọgwụ:

Switgbanwe insulin glargine 100 IU / ml ka Tujeo SoloStar® ga - eme ya n'otu nkeji, mana enwere ike ịchọ Tujeo SoloStar® dị elu iji mezuo ebumnuche glucose plasma.
Mgbe ị na-agbanwe site na iji ọgwụ Tujo SoloStar® na insulin glargine 100 IU / ml iji belata ihe ize ndụ nke hypoglycemia, ekwesịrị ịbelata dose ahụ (ihe dịka 20%), na-esote mmezi dose ma ọ bụrụ na ọ dị mkpa.

A na-atụ aro iji nlezianya nyocha metabolic n'oge izu ole na ole mbụ mgbe ọ gbanwechara otu ọgwụ ndị a gaa na nke ọzọ.
Na-agbanwe site na insulin basal ndị ọzọ na Tujeo SoloStar®

Mgbe ị na-agbanwe site na usoro ọgwụgwọ site na insulen nke etiti na ogologo oge na usoro ọgwụgwọ na Tujeo SoloStar®, ọ nwere ike ịdị mkpa ịgbanwe ọgwụ nke insal basal ma dozie usoro ọgwụgwọ hypoglycemic (gbanwee usoro na oge nchịkwa nke insulins adịghị mkpụmkpụ ma ọ bụ insulin insulin nke na-adịghị arụ ọrụ. ọgwụ).

Mgbanwe site na otu ntụtụ nke insulin insal n'oge ụbọchị gaa na otu nlekọta nke Tujeo SoloStar day n'oge ụbọchị ga - ebu ụzọ dabere na ngalaba otu nke insulin insulin na-achịkwa na mbụ.
Mgbe ị na-agbanwe site na nchịkwa insulin ugboro abụọ kwa otu na nchịkwa nke Tujeo SoloStar®, usoro ọgwụgwọ Tujeo SoloStar® na-atụ aro ka ọ bụrụ 80% nke ngụkọta kwa ụbọchị nke insulin basal, ọgwụgwọ nke kwụsịrị.

Ndị ọrịa nwere insulin dị elu, n'ihi ọnụnọ ọgwụ mgbochi insulin na mmadụ, nwere ike ị nweta nzaghachi ka mma maka Tujo SoloStar®.
N'oge mgbanwe nke ọgwụ Tujo SoloStar® ma n'ime izu ole na ole mgbe ọ gasịrị, a na-atụ aro nlezianya metabolic anya.
Site na njikwa metabolic dị mma na mmụba insulin na-ebute, enwere ike ịchọ ndozi usoro usoro ọgwụgwọ ọzọ. Enwere ike ịchọ mgbazi nke usoro dosing, dịka ọmụmaatụ, mgbe ịgbanwe ahụ mmadụ ma ọ bụ ibi ndụ onye ọrịa, mgbe oge nchịkwa nke dose nke insulin gbanwere, ma ọ bụ mgbe ọnọdụ ndị ọzọ bilitere na-eme ka ọnọdụ ahụ pụta na mmepe nke hypo-na hyperglycemia.
Mgbanwe site na ntinye ọgwụ Tujo SoloStar® na insulins ndị ọzọ basal

N'oge mgbanwe site na nchịkwa nke ọgwụ Tujo SoloStar® na ojiji nke insulin basal ndị ọzọ na mgbe izu ole na ole gasịrị, a na-atụ aro ka a na-ahụ maka nlekọta ahụike na nlebara anya metabolic anya.
A na-atụ aro ka ọ bụrụ aka na ntuziaka maka ọgwụ eji emegharị onye ọrịa ahụ.
Inggwakọta na izu
Ejikọtaghi Tujeo SoloStar® na insulin ọzọ. Mixgwakọta na-ebute mgbanwe na profaịlụ nke ihe omume Tujeo SoloStar® n'oge na-akpata ma na-ebute mmiri.
Tujeo SoloStar® ekwesịghị ịgwakọta. Mgbu mmiri nwere ike ibute mgbanwe na profaịlụ nke omume nke ọgwụ Tujo SoloStar® oge.
Ndị otu ọrịa pụrụ iche
Childrenmụaka
Emebebeghị nchekwa na ịdị irè nke ọgwụ Tujeo SoloStar® na ụmụaka na ụmụaka nọ n'afọ iri na asatọ (lee ngalaba "Pharmacokinetics").
Ndị okenye na-arịa ọrịa
Enwere ike iji Tujeo SoloStar® mee ihe na ndị ọrịa agadi. Ekwadoro ịkpachapụ anya ịbanye n'ọbara glucose, yana ịhọrọ insulin kwesịrị ịhọrọ ya n’otu n’otu. N’ime ndị ọrịa agadi, nsogbu na-aga n’ihu n’ọrụ gbasara akụrụ nwere ike ibute mbelata na -enwe insulin (lee ngalaba “Pharmacodynamics”, “Pharmacokinetics” na “Ntuziaka Pụrụ Iche”).
Ọrịa enweghị akụrụ
Enwere ike iji Tujeo SoloStar® mee ihe na ndị ọrịa nwere ọdịda akụrụngwa. Ekwadoro ịkpachapụ anya ịbanye n'ọbara glucose, yana ịhọrọ insulin kwesịrị ịhọrọ ya n’otu n’otu. N'ime ndị ọrịa nwere ezughi oke akụrụ, mkpa nke insulin nwere ike belata n'ihi nwayọ na metabolism metabolism (lee akụkụ "Ntuziaka pụrụ iche", "Pharmacodynamics" na "Pharmacokinetics").
Ndị ọrịa nwere ọrịa imeju
Enwere ike iji Tujeo SoloStar® mee ndị ọrịa nwere ọrịa imeju. Ekwadoro ịkpachapụ anya ịbanye n'ọbara glucose, yana ịhọrọ insulin kwesịrị ịhọrọ ya n’otu n’otu. N'ime ndị ọrịa nwere oke ịba ọcha n'anya, mkpa insulin nwere ike ibelata n'ihi mbelata gluconeogenesis na mbelata metabolism metabolism (lee akụkụ "Pharmacodynamics". "Pharmacokinetics" na "Ntuziaka Pụrụ Iche").
Ofzọ nke ngwa
Tujeo SoloStar® abanye n'ime oke abụba nke afọ, ubu ma ọ bụ n'úkwù. Ebe ndị irighiri ahụ kwesịrị iji ụzọ ọzọ dị mkpa dochie ụzọ maka ọgwụ nchịkwa.
Tujeo SoloStar® abụghị maka nhazi nchịkwa.
Ogologo oge insulin glargine na-ahụ maka ọ bụ naanị mgbe ewepụtara ya n'ime abụba dị n'okpuru ala. Nlekọta intravenous nke ọgwụ subcutaneous na-adịkarị nwere ike ibute nnukwu hypoglycemia.Tujeo SoloStar® abụghị maka iji insulin infusion pump.
Tujeo SoloStar® bụ ihe doro anya, ọ bụghị nkwụsị, yabụ ịmaliteghachị tupu iji ya abụghị ihe achọrọ.
Site na iji mkpịsị mkpụrụ osisi Tujeo SoloStar,, enwere ike inye doses nke 1 ruo 80 kwa ogwu ntụtụ na 1 nke dose.

Tujeo SoloStar® Syringe Pen Dose Counter na-egosi ọnụ ọgụgụ nkeji Tujeo SoloStar® nke a ga-elekọta. Edebere Tujeo SoloStar® Syringe Pen ka emebere nke ọma maka nkwadebe Tujeo SoloStar®, yabụ ntughari uzo ozo a choro achoghi.
Ekwesịrị ịwepụ Tujeo SoloStar® na ngwongwo mkpụrụ edemede sirinji n'ime sirinji (lee “Ntuziaka Pụrụ Iche”).
Ejila ihe ọzọ agịga. Tupu ntụtụ ọ bụla, a ga-ejikọ agịga ọhụrụ na - agwakọta. Iji ajị ọzọ were eme ihe nwere ike ibute ọrịa, nke nwere ike ibute obere ọgwụ ma ọ bụ doụbiga mmanya ókè. Na mgbakwunye, iji agịga ọhụụ na-egbu egbu maka ọgwụ ntụtụ ọ bụla na-ebelata ihe mmerụ na ibute ọrịa.
Ọ bụrụ na agịga etinyere, onye ọrịa ahụ ga-agbaso ntuziaka ahụ na Ntụpụ ụkwụ 3 “Ntuziaka maka Iji Tujeo SoloStar® Syringe Pen” (lee n'okpuru).

Iji gbochie ọrịa nwere ike ibuga n'ọbara, insulin insulin agaghị enwe ike karịa ọtụtụ ndị ọrịa, ọbụlagodi na a dochiri agịga ahụ.
Maka iji Tujeo SoloStar® Syringe Pen rụọ ọrụ nke ọma, lee n'okpuru "Ntuziaka maka Iji Tujeo SoloStar® Syringe Pen". Iji wezuga ohere nke insulin nke ọghọm (ihe ọghọm) nke ụdị insulin ọzọ karịa Tujeo SoloStar®, na-elele akara mgbe nile na mkpịsị edemede tupu ntụtụ ọ bụla (na akara mkpịsị ugodi Tujeo SoloStar,, a na-egosi nsonye "300 IU / ml" na agba agba) .
Okwu nke iji ogwu eme ihe na Tujeo SoloStar® pen sirinji ọgwụ disable mgbe ejiri nke mbu bu izu 4 mgbe echekwara ya n’ebe gbara ọchịchịrị. A na-atụ aro ka ọ gosipụta ụbọchị ojiji mbụ na akara nke mkpụrụ sirinji.