Noliprel A Fort > Ọgwụgwọ na mgbochi

Aha Latin: Noliprel A forte

Koodu ATX: C09BA04

Ngwakọta ọrụ: perindopril arginine (perindopril arginine) + ebepamide (ebepamide)

Onye na-emepụta ihe: Laboratories Servier Industry (France), Serdix, LLC (Russia)

Nkọwa na nwelite: 11/27/2018

Ahịa dị n'ụlọ ahịa ọgwụ: site na 564 rubles.

Noliprel A forte bụ ọgwụ jikọtara ọnụ, gụnyere angiotensin na - agbanwe enzyme inhibitor (ACE) na diuretic.

Mwepụta wepụtara ya na ihe mejupụtara

Ọgwụ dị n'ụdị mbadamba ihe eji eme ihe nkiri: oblong, white (in the polypropylene karama with dispenser: 14 or 29 pcs., N'ime igbe kaadiboodu nke nwere ikike imeghe nke mbu 1 karama, pcs iri ato. Karama 1 ma ọ bụ atọ, na ngwugwu maka ụlọ ọgwụ - karama iri atọ na pọọsụ kaadiboodu, na igbe kaadiboodu 1 pallet na ntuziaka maka iji Noliprel A forte).

Otu mbadamba 1 nwere:

bekee na-arụ ọrụ: perindopril arginine - 5 mg (nke kwekọrọ na ọdịnaya nke 3.395 mg perindopril), ebepamide - 1.25 mg,
ihe inyeaka: lactose monohydrate, siliki nke silicon dioxide anhydrous, maltodextrin, steepụ sodium carboxymethyl (ụdị A), magnesium stearate,
ihe odide mkpuchi ihe nkiri: premix maka mkpuchi ihe nkiri SEPIFILM 37781 RBC hypromellose, macrogol 6000, glycerol, titanium dioxide (E171), magnesium stearate, macrogol 6000.

Ọgwụ "Noliprel forte": mejupụtara na ụdị ntọhapụ

Ọgwụ dị n'ụdị mbadamba ụrọ nwere ihe nkiri echedoro. Ọgwụ a gụnyere ọtụtụ ihe na - arụ ọrụ n'otu oge, nke na - eweta nsonaazụ ya jikọtara ọnụ. Karịsịa, mbadamba ọ bụla nwere 10 mg perindopril arginine (ego a kwekọrọ na 6.79 mg perindopril) na 2.5 ml ebepamine.

N'ime imepụta ọgwụ ahụ, a na-ejikwa ihe ndị dị ka magnesium stearate, colloidal anhydrous silicon dioxide, lactose monohydrate, maltodextrin, hypromellose, macrogol 6000, glycerol na ụfọdụ ndị ọzọ ka ejiri mee ihe dị ka ndị enyemaka.

Ngwá ọgwụ ọgwụ

N'ezie, akụrụngwa nke ọgwụ ahụ bụ "Noliprel forte" jikọtara ya na mmetụta ya na anụ ahụ nke mejupụtara ya. Mana maka ndị na - ebido ebido, ọ bara uru ịmara na ọgwụ nwere mmetụta dị ike, ma na - emetụta ma systolic na diastolic pressure. Ogo mmetụta dị na nsonaazụ a dabere na dose. Nsonaazụ na-adịgide adịgide pụtara otu ọnwa tupu ọnwa ọgwụgwọ amalite.

Perindopril bụ otu n'ime ihe ndị mejupụtara ọgwụ ahụ. Ihe ndị a bụ ihe na - egbochi ụfọdụ ụdị enzyme. Ọ na - atọpụ arịa ọbara ma weghachi mgbidi nke mgbidi ha. Ọtụtụ nnyocha gosipụtara na perindropril na-ebelata ọbara mgbali, na iwepụ ọgwụ adịghị eduga na-awụlikwa elu. Ihe ọzọ na-arụ ọrụ, ebepamide, bụ otu na Njirimara ya nye thiazide diuretics. Akụkụ a na - egbochi iwepu ion potassium na nephron, nke na - eduga n'ịba ụba diuresis na excretion nke chlorine na sodium ion na mmamịrị.

Perindopril dị na mmamịrị ahụ. A na-ahụta nlebara anya kachasị anya ka awa 3-4 gachara. Banyere ebepamide, ọ na-amalite ịrụsi ọrụ ike mgbe otu elekere gachara, ya na mmamịrị na ọnya na-apụ apụ.

Mlọ ọgwụ

Noliprel A forte bụ ọgwụ ọgwụ hypotensive, nsonaazụ nke ya bụ n'ihi ihe ndị na - eme antihypertensive nke perindopril na ebepamide, na - eme ka ọ dị mma n'ihi njikọta ha.

Perindopril bụ ACE inhibitor nke na-ahụ maka ntụgharị nke angiotensin nke m ka ọ bụrụ ọgwụ vasoconstrictor angiotensin II. Na mgbakwunye, ACE (ma ọ bụ kininase II) na-agbanwe bradykinin ka ọ bụrụ heptapeptide na-adịghị arụ ọrụ. Bradykinin n’arụ nwere vasodilating mmetụta. N'ihi mgbochi ACE, ihe nzuzo nke aldosterone na-ebelata, usoro nzaghachi na-adịghị mma na-amalite, nke na-eme ka ọrụ renin dị na plasma ọbara. N'ihi mbido mbudata na mbugharị dị ala, arụ ọrụ myocardial bụ nke iwu. Ogologo oge eji perindopril na-enyere aka belata ngụkọta ngụgụ nke akwara (OPSS), nke kachasị n'ihi mmetụta ya na akwara ndị dị na akwara na akụrụ. A na - enweta mmetụta na - enweghị oge nke sodium na ion mmiri ma ọ bụ mmepe nke tachycardia reflex.

E guzobere ya na ọnọdụ nke obi obi na-adịghị ala ala (CHF), perindopril na-enye mbelata mgbanye mgbali aka na akaekpe na aka ekpe, mbelata obi, ịbawanye na mmepụta obi yana ịba ụba na uru ọbara.

Indapamide bụ sulfonamide nke ihe ndị dị na ya bụ ọgwụ yiri thiazide diuretics. Ọ na - egbochi mgbochi nke sodium ion na akụkụ cortical nke Henle loop, na - eme ka mmịpụta kloride, sodium, ma nwee ntakịrị magnesium na ion potassium site na akụrụ. Nke a na - abawanye diureis ma na - ebute mbelata ọbara mgbali elu (BP).

Mmetụta antihypertensive nke Noliprel A forte bụ ọgwụ dabere na okike, ebe ọ kwụ ọtọ ma gha ụgha ya, ọ na-egosipụta nhatanha n'ihe metụtara ọbara ọgbụgba na systolic ọbara. Mgbe ị takingụ ọgwụ ahụ, mmetụta ọgwụ ahụ na-adịgide ruo awa 24. Mmetụta ọgwụgwọ ahụ esetịpụtara nkwụsi ike mgbe ụbọchị 30 nke ọgwụgwọ gasịrị.

Contkwụsị usoro ọgwụgwọ na-esoghị ọrịa wepụ.

Site na iji Noliprel A forte, mbelata na OPSS, mbelata ogo hypertrophy ekpe aka ekpe (GTL), na mmelite bawanye akwara akwara. Ọgwụ a anaghị emetụta metabolism nke lipids na ọdịnaya nke mkpokọta cholesterol, cholesterol, lipoprotein dị elu (HDL) na obere npoprotein dị ala (LDL) ma ọ bụ triglycerides.

Site na ọbara mgbali elu na GTL, n'ihe banyere njikọta nke perindopril na ebepamide, a na-ahụwanye mbelata nke mkpụrụedemede aka ekpe (LVMI) yana mmetụta antihypertensive ma e jiri ya tụnyere enalapril.

Emere omumu banyere Noliprel A Forte na isi macro- na microvascular nsogbu ndị ọrịa nwere ụdị ọrịa shuga mellitus abụọ na mgbakwunye na usoro ọgwụgwọ abụọ maka njikwa glycemic na atụmatụ nchịkwa glycemic siri ike (IHC) (lekwasịrị HbA lekwasịrị anya)_1c erughị 6.5%). Otu ìgwè ndị ọrịa sonyere n'ọmụmụ ihe ahụ, nkezi ndị gosipụtara nke bụ: afọ 66 afọ, ọbara mgbali 145/81 mm Hg, arọ uka index 28 n'arọ kwa 1 m 2 nke ahụ elu, HbA1c (glycosylated haemoglobin) 7.5%. Imirikiti ndị ọrịa nọ na hypoglycemic na ọgwụ concomitant (gụnyere antihypertensive, hypoliplera, ndị nnọchi antiplatelet).

Nsonaazụ nyocha (oge nlere dị ihe dị ka afọ 5) gosipụtara mbelata 10% n'ihe ọghọm dị na njikọta ogologo oge nke nnukwu macro- yana nsogbu microvaskụla na ndị otu IHC (nkezi HbA_1c 6.5%) atụnyere ndị ọkọlọtọ akara otu (ọkara HbA_1c 7,3%).

E mere ka mbelata ihe egwu dị na nwute 14% na nsogbu microvaskụla bụ isi, 21% maka ntolite na ọganihu nke nephropathy, 9% maka microalbuminuria, 30% maka macroalbuminuria, na 11% maka mmepe nsogbu nsogbu akụrụ.

Abamuru nke usoro ọgwụgwọ antihypertensive adabereghị na uru ndị enwere na IHC.

A na-enyocha ịdị irè antihypertensive nke perindopril maka ọgwụgwọ nke ọbara mgbali elu nke akwara. Mgbe otu onye na-achịkwa otu edere, a na-enweta mmetụta kachasị elu nke Noliprel A Forte mgbe awa 4-6 gachara, ọ na-adịgidekwa ruo awa 24. A na-ahụta ihe mkpofu (ihe dị ka 80%) mgbochi ACE awa 24 mgbe nchịkwa ya gasịrị.

Perindopril nwere mmetụta hypotensive na ọrụ plasma renin dị ala na nke nkịtị.

Njikọ ya na thiazide diuretics na-abawanye ike nke mmetụta antihypertensive, na-ebelata ihe ize ndụ nke hypokalemia n'ihi ị ofụ diuretics.

Ọgwụ nkwonkwo nke nwere ACE inhibitor na antiotensin II receptor antagonist (ARA II) na ndị ọrịa nwere akụkọ banyere ọrịa obi ma ọ bụ ọrịa ọrịa ụbụrụ, ndị ọrịa nwere ụdị ọrịa shuga 2 (nke achọpụtara na ọ nwere mmebi ahụ), ụdị ọrịa shuga 2 na ọrịa nephropathy abụghị ọrịa. Mmetụta dị mma dị ukwuu na ihe gbasara akụrụngwa na / ma ọ bụ ọrịa obi ma ọ bụ ọnụego ọnwụ. Mana mgbe atụnyere ya na monotherapy, achọpụtara na na nzụlite nke njikọta nke ACE inhibitor na ARA II, ihe ọghọm nke ịmalite hyperkalemia, nnukwu akụrụ renal na / ma ọ bụ hypotension hypotension na-abawanye.

N'iburu n'uche na intragroup pharmacodynamic Njirimara nke ndị na-egbochi ACE na ARA II yiri nke a, enwere ike ịtụ anya nsonaazụ ndị a na ngwakọta nke perindopril na ARA II.

A naghị atụ aro iji ya ndị na-egbochi ACE na ARA II n'otu oge na ndị ọrịa nwere ọrịa nephropathy.

Ihe mgbakwunye nke aliskiren to type 2 diabetes mellitus na ọrịa akụrụ na-adịghị ala ala na / ma ọ bụ ọrịa obi na ọkọlọtọ ACE ma ọ bụ usoro ọgwụgwọ inAbrial II na-abawanye ihe ọghọm nke nsonaazụ, gụnyere ọnwụ obi, ọnya ọnya, mmepe nke hyperkalemia, hypotension artpapi na arụ ọrụ ezumike arụ ọrụ .

Iji ebepamide na doses nwere ntakịrị diuretic mmetụta na-akpata mbelata na OPSS, na-eme ka akwara na-agbanwe agbanwe nke nnukwu akwara, na-enye ya mmetụta antihypertensive. Na-enweghị emetụta ọkwa nke lipids na plasma ọbara (triglycerides, cholesterol zuru oke, LDL, HDL) na metabolism metabolism (gụnyere ndị ọrịa nwere ọrịa mellitus), ebepamide na-enyere aka belata GTL.

Mlọ ọgwụ

Njirimara nke pharmacokinetic dị na monotherapy yana ọgwụ ọ bụla agbanweghị na njikọta nke perindopril na ebepamide.

Mgbe nchịkwa ọnụ, njide nke perindopril pụtara ngwa ngwa, bioav adị ya nwere ike ịbụ site na 65 ruo 70%. Ihe dị ka 20% nke ọgwụ a na-etinye na ọgwụ ahụ bụ biotransformedite na metabolite perindoprilat nọ n'ọrụ. Oke ntinye ya (C_max) ọbara plasma ruru mgbe awa 3-4 gachara. Mkpokọta oge na-ebelata ntụgharị nke perindopril gaa perindoprilat na-enweghị nsonaazụ ụlọ ọgwụ.

Mgbe nnabata oropamide ngwa ngwa site na eriri afọ zuru oke na oke ae were, C_max n'ime plasma ọbara ruru n'ime otu elekere site na nmalite.

Na - ejikọ protein protein Plasma: perindopril - erughị 30%, ebepamide - 79%.

Nkewa nke ACE metụtara perindoprilat ji nwayọ nwayọ, yabụ, ọkara ndụ na-arụ ọrụ (T_1/2) perindopril - 25 awa. Ego steeti na-erite ihe ruru awa 96.

Perindopril na-agafe oghere mgbochi.

Nnweta Noliprel mgbe nile A forte adịghị eduga na nchịkọta n'ime ahụ ya.

Perindoprilat bụpụrụ akụrụ, T_1/2 Ọ bụ awa 3-5.

Ndi_1/2 ebepamide na-awa 19 awa. A na - ekewa ya n'ụdị metabolites na - adịghị arụ ọrụ: site na akụrụ - 70% nke ọgwụ aewere, site na eriri afọ - 22%.

Nwepu nke perindoprilat n'oge akwara di 70 ml / min.

Site na akwara gbasara obi na nkụda mmụọ, yana ndị ọrịa agadi, excretion nke perindoprilat belatara.

Site na imeju nke imeju, mgbochi hepatic nke perindopril belatara ugboro abụọ, mana nke a anaghị emetụta ego nke perindoprilat, ya mere, a chọghị ịmegharị dose.

N'ime ndị ọrịa nwere ọdịda akụrụngwa, ọgwụ ọgwụ nke ebepamide adịghị agbanwe.

Ihe ngbanwe

oke oke imeju, gụnyere nsogbu nke encephalopathy,
nnukwu ọdịda gbasara akụrụngwa ya na nwado (creatinine) (CC) erughi 30 ml / min,
ọnụọgụ abụọ
ọnụnọ nke akụrụ na-arụ ọrụ,
ihe eji agwọ ugwo,
hypokalemia
Obi erughi ala,
concomitant ọgwụ na ọgwụ na-agbatị oge QT,
ngwakọta na ọgwụ antiarrhythmic nke nwere ike ibute arrhythmias ventricular dịka "pirouette",
n'otu oge iji ọgwụ ọjọọ nwere aliskiren na ndị ọrịa nwere ọrịa mellitus ma ọ bụ arụ ọrụ na-arụ ọrụ na-arụ ọrụ (GFR erughị 60 ml / min kwa 1.73 m2 nke akụkụ ahụ dị elu),
Ọrịa glucose-galactose malabsorption syndrome, galactosemia, ụkọ lactase,
hereditary ma ọ bụ idiopathic angioedema,
ihe ngosi banyere akuko banyere anakpo angioedema, tinyere ojiji nke ACE inhibitors,
oge ime
inye ara
afọ ruo afọ 18
gosipụtara ihe mgbochi nye ndị ọzọ ACE inhibitors ma ọ bụ sulfonamides,
mmadụ inabata ya na ọgwụ ndị ahụ.

N'iji nlezianya mee ya, a na-atụ aro ka Noliprel A forte nye ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala nke klaasị arụ ọrụ IV dị ka nhazi NYHA (New York Obi Association), angina pectoris, mgbali ume ọkụ ọgbụgba, aortic valvụ stenosis, ọbara ọgbụgba na-egbochi obi mgbawa, ụkwara ọkpụkpụ na-agba ume (mbelata ọbara) (gụnyere nsonaazụ nke ị diụ nsị, ịgbanye nri na-enweghị nnu, yana ọgbụgbọ, afọ ọsịsa ma ọ bụ ịba ọcha n'anya), ọrịa ụbụrụ. abolevaniyami, ọrịa shuga, imeju ọdịda, systemic connective anụ ahụ ọrịa (gụnyere scleroderma, systemic lupus erythematosus), na lability nke ọbara mgbali, hyperuricemia (karịsịa so urate gout na nephrolithiasis), ndị agadi, nakwa dị ka ọkachamara na-eme egwuregwu na ndị ọrịa ojii.

Na mgbakwunye, a na-adụ ọdụ ịkpachara anya mgbe ị na-eji immunosuppressants, nkwadebe lithium, hemodialysis na-eji membranes dị elu, desensitization, tupu usoro apheresis LDL, anesthesia, na ntụgharị akụrụ.

Nsonaazụ

site na akwara dị n’etiti: ọtụtụ mgbe - isi ọwụwa, vertigo, dizziness, asthenia, paresthesia, infrequently - lability mood, nsogbu ihi ụra, ọ na - adịkarịghị - ọgba aghara, ugboro ugboro ejighi - ada mba,
site na sistemmuzu ọbara na okirikiri: ọ na - esiri ike - leukopenia, neutropenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, anaemia (mgbe akụrụ akụrụ, akwara n’ọbara),
n'akụkụ nke usoro akwara obi: ọtụtụ mgbe - mbelata ọbara mgbali elu (gụnyere hyịnrịa orthostatic), ọ dịkarịsịrị ike - cardiac arrhythmias (gụnyere bradycardia, ventricular tachycardia, atrial fibrillation), angina pectoris, infarction myocardial, ugboro adịghị guzobere - pirouette type arrhythmia, gụnyere egbu egbu,
site na akwara anụ ahụ: ọtụtụ mgbe - tinnitus, ọhụhụ ụzọ,
site na okuku ume, akwara na akụkụ ahụ: mgbe mgbe - ụkwara na - adịte aka (n'ihi ogologo oge iji perindopril), mkpụmkpụ ume, ugboro ugboro - bronchospasm, ọ na - adịkarị - rhinitis, posonia eosinophilic,
site na nri digestive: ọtụtụ mgbe - imebi uto, akpịrị ịkpọ nkụ, agụụ belata, ọgbụgbọ, ọgbụgbọ, mgbu epigastric, mgbu afọ, afọ ntachi, afọ ọsịsa, dyspepsia, adịkarịghị - pancreatitis, angioedema, cholestatic jaundice, cytolytic ma ọ bụ cholestatic ịba ọcha n'anya, na-agaghị guzobere ugboro - hepatic encephalopathy (ya na imeju ọdịda),
mmeghachi omume nfụkasị: oge adịghị - urticaria, angioedema nke ihu, egbugbere ọnụ, ire, aka na aka, olu nke akwara ụda olu na / ma ọ bụ akwara, ma ọ bụrụ na enwere ihe mgbochi nke ihe nsị nke ụbụrụ na mmeghachi ahụ nfụkasị - mmeghachi omume hypersensitivity,
mmeghachi omume nke akpomkpomoku: otutu oge - itching, akpukpo aru, ihe ngbama nke aru aru, oria akari - nke na - akawanye njọ nke systemic lupus erythematosus, purpura, a di otutu - oria ojoo necrolysis, erythema multiforme, Stevens-Johnson syndrome, photoensitivity,
site na musculoskeletal system: mgbe mgbe - akwara nke akwara,
site na usoro ọmụmụ: enweghi ike - enweghi ike,
site na urinary system: ugboro ugboro - gbasara akụrụ odida, nke ukwuu adịkarịghị - nnukwu gbasara akụrụ odida,
ihe nlere nke ulo nyocha: adighi ike - hypercalcemia, oge emebeghị ka ọ dị - mmụba na oge QT na electrocardiogram, mmụba nke glucose na uric acid n'ime ọbara, mmụba na ọrụ nke enzymes imeju, hypokalemia, hyponatremia, hypovolemia, hyperkalemia, ntakịrị mmụba na mmamịrị na ọbara.
mmeghachi omume izugbe: ọtụtụ mgbe - asthenia, ugboro ugboro - ịba ụba aja.

Dodoụbiga ya ókè

Mgbaàmà: mbelata nke ọbara mgbali elu, nke jikọtara ya na ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, iro ụra, cramps, ọgba aghara, oliguria, oge ụfọdụ na-atụgharịzi na anuria n'ihi hypovolemia, mmiri mmiri elektrolyte (hyponatremia na hypokalemia).

Ọgwụgwọ: lavage gastric ozugbo, ntinye nke carbon na-arụ ọrụ, mweghachi nke nguzo mmiri-electrolyte. Site na nnukwu hypotension, ekwesịrị itinye onye ọrịa ahụ n'azu ya ma welie ụkwụ ya elu. Iji hụ na iji nlezianya nyochaa ọnọdụ onye ọrịa, ya na hypovolemia - iji mepụta iv (infusion) infusion 0.9% sodium chloride solution.

Ikekwe ihe gbasara ọgwụgwọ.

Ntụziaka pụrụ iche

Ojiji nke Noliprel A forte yana njirimara mmetụta nke monotherapy na perindopril na ebepamide na usoro ọgwụgwọ kachasị ala. N'ime ndị ọrịa na-enwetabeghị ọgwụ mbụ maka ọgwụ antihypertensive, enwere ihe ọghọm nke idiosyncrasy, yabụ kpachapụrụ anya wee chọọ iji belata ihe egwu a.

Ọ bụrụ na achọpụtara ihe nlere ime ụlọ arụmọrụ n'oge umeji, a ga-akwụsị ịhapụ ị treatmentụ ọgwụ ahụ. Ka ịmaliteghachi usoro njikọta ọgwụ, a na-atụ aro ka iji ọgwụ ọ bụla dị ala ma ọ bụ kọọ naanị otu n'ime ha. N'okwu a, ndị ọrịa chọrọ nleba anya oge niile nke serum potassium na ọkwa creatinine. Emere ọmụmụ ihe ụbọchị iri na anọ mgbe mmalite nke ọgwụgwọ wee rịa otu oge na ụbọchị 60.

N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala ma nwee nsogbu akụrụngwa izizi (gụnyere akwara akwara stenosis), ọdịda akụrụ na-apụta ugboro ugboro.

Na mberede mmepe hypotension bụ ike dịkarịsịrị na hyponatremia mbụ, ọkachasị ndị ọrịa nwere akwara gbasara akwara stenosis. Yabụ, mgbe afọ ọsịsịrị ma ọ bụ ọgbụgbọ, ọ dị mkpa iburu n'uche mmụba nke anụ ahụ na mbelata ihe ndị dị na mmiri nke ọbara. N'iburu oke ọgbụgba ike, a na-egosipụta nchịkwa 0.9% sodium chloride solution.

Ọbara mgbatị akwara nwa oge abụghị ihe kpatara ịkwụsị ọrịa. Mgbe mweghachi nke BCC na ọbara mgbali elu, enwere ike ịmaliteghachi ọgwụgwọ site na iji usoro mmiri abụọ na-arụ ọrụ ma ọ bụ otu n'ime ha.

Ekwesịrị ijikwa ọgwụgwọ mgbe niile na potassium na plasma ọbara, karịsịa na ọrịa shuga mellitus na ọdịda akụrụ.

A ga-akwụsị iji Noliprel A Fort awa 24 tupu mmalite nke enweghị nkụda mmụọ.

Tupu usoro apheresis LDL ọ bụla site na iji dextran sulfate, a ga-akwụsị nchịkwa nke ACE inhibitor nwa oge.

N'ime ndị ọrịa na-anara ọgwụgwọ perindopril, membranes nwere nnukwu elele enweghị ike iji ya mee ihe n'oge usoro ịba uru. Ekwesịrị ka edochie ha nke membranes ndị ọzọ ma ọ bụ usoro ọgwụgwọ ọzọ na-egbochi ọgwụ iji nye onye ọrịa ahụ iji ọgwụ nke otu ọgwụ ọgwụ ọzọ.

N'ime nchọpụta nke ụkwara na-adịghị ala ala nke bilitere n'oge usoro ọgwụgwọ, ekwesịrị iburu n'uche na iji ihe mgbochi ACE nwere ike ịbụ ihe kpatara ọdịdị ya.

N'ihi oke ihe egwu nke etolite neutropenia, agranulocytosis, thrombocytopenia, na anaemia, ekwesịrị ilebara anya pụrụ iche mgbe ị na-edepụta ndị ọrịa ọrịa systemic nke anụ ahụ na - ejide immunosuppressants, procainamide ma ọ bụ allopurinol, ọkachasị na arụ ọrụ sistemu arụ ọrụ na mbụ. Ndị ọrịa a nọ n'ihe egwu dị elu nke ibute ọrịa na-efe efe, na-ejikarị ọgwụ mgbochi ọgwụ siri ike. A na-atụ aro iji Noliprel A Forte na ụdị ndị ọrịa a ka ọ bụrụ ihe nlere anya maka ọnụọgụ nke leukocytes n'ọbara. Ekwesịrị ime ka ha mata banyere mkpa ọ dị ịkpọtụrụ dọkịta ozugbo ma ọ bụrụ na akpịrị na-egbu mgbu, ahụ ọkụ na akara ndị ọzọ nke ọrịa na-efe efe.

Site na mbelata ọbara plasma electrolytes na hypovolemia dị ala, na mbido ọbara mgbali elu, akwara akwara stenosis, ọrịa obi na-adịghị ala ala, ma ọ bụ imeju nke imeju na edema na ascites, mmụba dị ukwuu nke renin-aldosterone-angiotensin system (RAAS) nwere ike ime n'ihi mgbochi nke usoro a site na perindopril. Ọnọdụ onye ọrịa nwere ike ibute na mbelata ọbara mgbali elu, mmụba na creatinine na plasma ọbara, mmepe nke ọdịda akụrụngwa nke arụ ọrụ. A na - ahụkarị ihe ịtụnanya ndị a n’ime ụbọchị iri na anọ izizi nke ọgwụgwọ. A na-atụ aro ka ịmaliteghachi ọgwụ ahụ na ntakịrị ala.

Maka ọbara mgbali elu na ndị ọrịa nwere ọrịa obi na mkpụrụ obi (CHD), ụbụrụ nke ụbụrụ (ụbụrụ), ụbụrụ obi na-adịghị ala ala na / ma ọ bụ ụdị shuga 1, a ga-amalite iji ọgwụgwọ were obere ọgwụ. Ndị ọrịa nwere ọrịa akwara ọbara kwesịrị iwere ndị na-egbochi ACE yana beta mgbochi.

N'ihi ihe egwu nke ịba anaemia n'ime ndị ọrịa na-emegharị ntụgharị akụrụ ma ọ bụ na-ele hemodialysis, ọgwụgwọ kwesịrị ịmụrụ ya na nyocha nke ọbara.

Tupu ogwugwo ahụ sara mbara, a ga-akwụsị Noliprel A Fort awa iri abụọ na anọ tupu ịmalite ịwa ahụ izugbe.

Ekwesiri iburu n'uche na n'ime ndị ọrịa nke agbụrụ Negroid, mmetụta antihypertensive nke perindopril apụtaghị.

N'ihe banyere ọrụ imeju na-emebi emebi, ebepamide nwere ike ibute mmepe nke encephalopathy hepatic, na-achọ ịkwụsị ọgwụ ahụ ozugbo.

Ekwesịrị ime oge Noliprel ike ga - eburu n'uche nsonaazụ nke ọmụmụ banyere nguzo mmiri-electrolyte (gụnyere ọdịnaya nke sodium, potassium na calcium ion na plasma ọbara) nke onye ọrịa, mgbe nke ahụ gasịrị, ọ dị mkpa ileba anya n'ụlọ nyocha mgbe niile.

Hypokalemia na ndị ọrịa merela agadi, ndị ọrịa na-adịghị edozi ahụ, ndị ọrịa nwere nkụchi obi, ọrịa obi na-efe efe, cirrhosis (ya na edema ma ọ bụ ascites) na-eme ka mmetụta bekee nke glycosides ike na-eto ma nwekwuo ohere nke arrhythmias.

N'oge ọgwụgwọ ọrịa akwara, ọkwa plasma uric acid dị elu nwere ike ịbawanye ohere nke ọgụ goout.

Enwere ike ịkwenye ịdị irè nke ọgwụgwọ na thiazide na thiazide dị ka ihe mgbaze thiazide naanị na ọrụ ezigharịrị ma ọ bụ nke na-adịghị obere. Nleta plasma creatinine dị na ndị okenye toro eto kwesịrị ịdị n'okpuru 2.5 mg / dL ma ọ bụ 220 μmol / L. Maka ndị ọrịa agadi, a na-agbanwe ya maka afọ, okike, na ịdị arọ site na iji usoro Cockcroft. A na-ekpebi ọkọlọtọ ngosipụta nke plasma creatinine na ụmụ nwoke site na ịbawanye ihe dị iche (afọ nwute iri abụọ) site na ịdị arọ nke onye ọrịa na kilogram ma kesaa ihe nsonaazụ site na ịta plasma creatinine (μmol / L), mụbara site na 0.814. Iji kpebie mata nke a maka ụmụ nwanyị, ihe ikpeazụ ga-amụrịrị site na 0.85.

Maka ndị ọrịa nwere ọrụ gbasara akụrụngwa nkịtị, ọdịdị nke ọdịda ezumike ezi nwa adịghị ize ndụ. Site na ọdịda akụrụngwa nke mbu, mbelata na GFR, mmụba nke urea na creatinine na plasma ọbara nwere ike nwekwu agwa na nsonaazụ dị njọ.

N'ihi ihe egwu a na-emeghachi omume n'oge Noliprel A Forte, a na-atụ aro ka ọ ghara ịdọrọ ọkụ ọkụ ma ọ bụ radieshon ultraviolet.

Okwesiri iburu n’uche na mgbe ị na-eme ka nchịkwa doping na ndị na-eme egwuregwu, ebepamide nwere ike inye mmeghachi omume dị mma.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Noliprel A forte anaghị eme ka mmebi nke psychomotor na-emeghachi omume. Agbanyeghị, n'ihi ihe egwu dị ugbu a nke ịmalite ihe ọghọm nke na-ebute megide ndabere nke mbelata ọbara mgbali elu ma ọ bụ n'oge mmezi ọgwụgwọ, a na-adụ ọdụ mgbe ọ na-anya ụgbọ ala na usoro mgbagwoju anya, ọkachasị na mmalite ọgwụgwọ.

Ime na lactation

Ihe Noliprel A Forte na - egbochi ime n'oge a na-enye ya ara na ara.

Mgbe ị na-eme atụmatụ ịtụrụ ime ma ọ bụ na-atụrụ ime n’oge ọgwụgwọ, ekwesịrị ịkwụsị ọgwụ a ma bụrụ onye ọgwụ hypotensive akwadoro iji mee n’oge afọ ime.

Ojiji nke ACE inhibitors na II - III nke afọ ime nwere ike ibute nnukwu nsogbu nke mmepe nwa ebu n'afọ (ọrụ nwatakịrị, igbu oge nke ọkpụkpụ nke okpokoro isi, oligohydramnios) na mmepe nke nsogbu na nwa amụrụ ọhụrụ (ọdịda akwara, ụkwara ume ọkụ na / ma ọ bụ hyperkalemia).

Na mgbakwunye, usoro ọgwụgwọ ogologo oge na thiazide diuretics na III trimester nke afọ ime na-emetụta ọbara nke utero-placental, na-ebute hypovolemia na nne.

Na arụ ọrụ ezumike ọrụ

Ihe Noliprel A Forte nwere contraindicated na nnukwu akụrụ odida (CC erughị 30 ml / min).

Na ọdịda akụrụngwa na ndị ọrịa nwere CC 30-60 ml / min, nhọpụta nke ọgwụ ejikọtara ọnụ kwesịrị ịmechaa mgbe monotherapy nke mbụ na-arụ ọrụ nke ọ bụla. Ọ dị mkpa iji doses na-enye ohere iji nweta ọgwụgwọ ọgwụgwọ a na-anabata nke ọma.

Na mmezi akụrụngwa ya na CC 60 ml / min ma karịa, a na-enyekarị ọgwụ Noliprel A forte, na-esochi usoro nlele anya na ọkwa Plasma creatinine na potassium.

Mkparịta ụka ọgwụ ọjọọ

Ngwakọta lithium: njikọta nke ACE inhibitor na nhazi lithium na-eme ka ohere nke mmụba nke lithium dị na plasma ọbara na mmepe nke nsonaazụ nsị. Ọnụnọ nke thiazide diuretics na-eme ka ihe na-apụta. A naghị atụ aro iji ọgwụ na-anabata oriri na nkwadebe lithium. Ọ bụrụ na ọ dị mkpa ịmụrụ ọgwụ ngwakọta, achọrọ ileba anya n'ihe niile lithium dị na plasma ọbara,
baclofen: na - akwalite mmetụta hypotensive. Maka nhazigharị ọgwụ n'oge, a ga-enyocha ọrụ akụrụ yana ọbara mgbali.
ọgwụ mgbochi na - abụghị steroidal anti-inflammatory (NSAIDs) (gụnyere ọgwụ kwa ụbọchị nke acetylsalicylic acid dị elu karịa 3 g): cyclooxygenase-2 inhibitors (COX-2), NSAIDs na - abụghị nhọrọ na ọgwụ mgbochi mkpali nke acetylsalicylic acid na - belata mmetụta antihypertensive nke perindopril ma nwekwuo ihe ize ndụ nke ibu na-akpata na-abawanye ọbara potassium ọdịnaya (karịsịa na ibido mgbadalata akụrụ ọrụ)
ọgwụ tricyclic antidepressants, antipsychotics (antipsychotics): site na iji Noliprel A na-eme n'otu oge, ha na-akwalite mmetụta hypotensive, na-abawanye ihe ize ndụ nke hypotension orthostatic,
corticosteroids, tetracosactide: kpatara mbelata na mmetụta antihypertensive. Ihe corticosteroids na-akwalite njigide nke mmiri na sodium ion,
ọgwụ ndị ọzọ na - egbochi ọgwụ na ọnụ na vasodilators: nwere ike ịkwalite mmetụta hypotensive nke ọgwụ ahụ. Nitroglycerin, nitrates na vasodilators nwere ike inwekwu mbelata ọbara mgbali,
Mgbakwunye potassium-sparing diuretics (gụnyere amiloride, spironolactone, eplerenone, triamteren), nkwado potassium, nnọchi ndị nwere potassium maka nnu a na-eri: ndị nnọchianya ndị a nwere ike ime ka mmụba dị ukwuu na ọkwa nke potassium na ọbara n'ọbara, gụnyere ndị na-egbu egbu. N'akụkụ a, na hypokalemia enen, ihe ha na ọgwụ a ga-agbakwunye ga na-esochi anya ihe ọdịnaya potassium na ọkwa plasma ọbara na ECG,
estramustine: nsogbu nke ịmalite ọrịa angioedema na ihe ọjọọ ndị ọzọ yiri ya
Nchịkwa insulin na sulfonylurea (ndị na-arịa ọnya hypoglycemic): n'ime ndị ọrịa nwere ọrịa shuga, enwere ike ịkwalite mmetụta hypoglycemic nke insulin na usoro sulfonylurea,
allopurinol, immunosuppressive na cytostatic na-elekọta mmadụ, corticosteroids maka iji usoro, procainamide: njikọta na ndị ọrụ a nwere ike ịbawanye ohere nke ịmalite leukopenia,
ọgwụ izukari ọgwụ izugbe: ị :ụ ọgwụ mgbochi ọrịa izugbe ka ọ na-akwalite mmetụta antihypertensive,
thiazide na “loop” diuretics: nnukwu usoro ọgwụgwọ diuretics nwere ike ibute hypovolemia na hypotension,
linagliptin, sitagliptin, vildagliptin, saxagliptin (gliptins): mee ka ohere nke angioedema dịkwuo elu,
ọrịa obi: ike ịkụzi mmetụta antihypertensive,
Nkwado ọla edo: megide ihe gbasara iv ochichi nke nkwado ọla edo, mmeghachi nke nitrate nwere ike ịmalite (hyperemia ihu anụ ahụ, hypotension artial, ọgbụgbọ, ọgbụgbọ),
quinidine, sabapiramide, hydroquinidine (ọgwụ antiarrhythmic nke klas IA), ibutilide, amiodarone, dofetilide, bretilia tosylate (antiarrhythmic ọgwụ nke klas III), sotalol, chlorpromazine, ciamemazine, levomepromazine, threidape cyterol, sirinji, akwara droperidol, haloperidol, pimozide, bepridil, diphenyl methyl sulfate, cisapride, erythromycin na vincamine (iv), misolastine, moxifloxacin, pentamidine, halofantrine, sparfloxacin, methadone, terfenadle, astemizole: ebepamide nwere ike itinye aka na mbelata nke potassium na plasma ọbara na ihe mere Pirouette ụdị arrhythmias. Ọ bụrụ na ọ dị mkpa ịdebe ego ndị a, a ga-elebara anya pụrụ iche iji chịkwaa ihe ndị dị na potassium na plasma ọbara na etiti QT,
amphotericin B (iv), glucocorticoids na systemralocorticoids, tetracosactides na laxatives nke na-akpali motility eriri afọ: dịkwuo ihe ize ndụ nke hypokalemia,
Cardiac glycosides: ekwesiri iburu n'uche na hypokalemia nwere ike iwelie mmetụta uto nke cardiac glycosides, ya mere, a na-atụ aro ịchịkwa ọdịnaya potassium na plasma ọbara na ECG ma mee mmezi kwesịrị ekwesị nke ọgwụgwọ,
metformin: ọnụnọ nke ọdịda akụrụngwa nke arụrụ na - eme mgbe a na - a aụ ya, nke a ga - atụle, ma ọ bụrụ na ejikọtara ya na metformin, na - ebulite ohere nke lactic acidosis. Ọ bụrụ na itinye uche nke Chukwuịnine n'ime plasma ọbara n'ime ụmụ nwoke karịrị 15 mg / l, na ụmụ nwanyị - 12 mg / l, ekwesighi inye ọgwụ metformin,
iodine ndi nwere ihe ndi ozo di iche: otutu onodu ayodiin nwere ihe ndi na egosi ihe megide ahihia akpukpo (n'ihi onodu nke oria diuretic) nke ahu gha eme ka akpochapu akwara ghara idi ire, nke choro ugwo maka onwusi mmiri tupu iwere iodine ndi nwere ihe di iche.
calcium salts: mbelata nke mpụta nke calcium ion site na akụrụ ga - ekwe omume, nke a na - ebute oke nsogbu nke ịrịa hypercalcemia,
cyclosporine: ịta nke cyclosporine na plasma ọbara adịghị agbanwe agbanwe, mana enwere ike ịbawanye creatinine na plasma ọbara, gụnyere ọdịnaya nkịtị na mmiri na sodium ion.

Ihe atụ nke Noliprel A forte bụ: Noliprel, Noliprel A Bi-forte, Perindopril PLUS Indapamide, Co-Parnavel, Indapamide / Perindopril-Teva, Co-Perineva, Co-Preness, Perindapam, Perindide, Perindopril-Indapamide Richter.

Nkọwa ọgwụ

Ngwakọta nke mbadamba ndị ahụ gụnyere Perindopril na Indapamide. Ihe abuo a nwere uto antihypertensive, ma wedata mitomita n’uzo di iche.

Perindopril bụ ACE inhibitor, yana Indapamide bụ ndị otu sulfonamide diuretics. Na nchịkọta, ihe ndị a na-eme ka ibe ha na-emekọ ihe.

Denye ọgwụ maka mbelata nrụgide Symptomatic. Ọtụtụ mgbe, dọkịta na-agụnye Noliprel n'ịgwọ ọbara mgbali ala ala.

Mmetụta hypotensive kachasị na-etolite mgbe ọnwa nchịkwa wee dịgide ruo ogologo oge. Ọgwụ a dị irè ọbụlagodi mgbe ọgwụ ndị ọzọ na - egbochi akụnụba adịghị enyere ha aka.

N'otu oge ahụ, ọnụahịa nke mbadamba ihe dị ntakịrị. Ọtụtụ mmadụ na-azụta Noliprel, mana ha amaghị ka esi ewere ya. N'ihi nke a, mkpesa na-ebilitekarị na ngwaahịa anaghị arụ ọrụ ma ọ bụ belata tonometer nke ukwuu.

Nyocha na Noliprel A Fort

Nyocha banyere Noliprel A Fort dị mma. Ndị ọrịa nwere ahụmịhe banyere ọgwụgwọ nke ọbara ọgbụgba akwara ozi na-akọ na ịgbanye Noliprel A forte nyere ha ohere ịme ka ọ̀tụ̀tụ̀ ọbara ji erugharị, na iri nri mgbe nile na-eme ka ahụ kwụsie ike. N'ịrụ aka na ịdị irè nke ọgwụ ahụ, a na-adụ ndị ọrụ ọdụ ka ha ghara ịmalite ị theụ ọgwụ ahụ na-agwaghị dọkịta.

Dosages nke Noliprel

A na-ahapụ Noliprel n'ụdị dị iche iche. Ọ bara uru maka ndị ọrịa na ndị dọkịta ịghọta ụdị nyocha a.

Noliprel A Bi-Forte

Ndi iche iche nke mbadamba ihe jikọtara diri iche:

Noliprel (nwere 2 mg perindopril na 0.625 mg diuretic),
Noliprel Forte (usoro onunu ogwu ebepamide bụ 1.25 mg, perindopril bụ 4 mg)
Noliprel A Forte (ebepamide - 1.25 mg, perindopril - 5 mg),
Noliprel A Bi-Forte (perindopril dị na ọgwụ 10 mg, yana diuretic - 2.5 mg),
Noliprel A (2.5 mg perindopril na 0.625 mg ebepamide).

Edere Noliprel A Bi-Forte ọtụtụ oge maka elele dị elu. Ọ bụrụ na enwere ọtụtụ ọgwụ a, dọkịta ahụ na-ahọrọ mbadamba nwere obere ọdịnaya nke perindopril na indapamide.

Ọgwụ Noliprel A, A Bi-Forte na A Forte nwere amgin acid arginine, nke nwere uru na sistem.

Ya mere, ọ bụrụ na enwere nsogbu obi, ọ bara uru iji ọgwụ ndị a dị n'elu. Maka onye ọrịa ọ bụla, a na-ahọrọ usoro onyonyo otu n'otu, na-eburu usoro nkwanye ugwu, afọ. A na-atụ aro ka ndị ọrịa hypertensive nke agadi ka ịmalite ọgwụgwọ otu mbadamba.

Esi a tabletsụ mbadamba ihe ọ bụla?

A na-ewere ọgwụ a jikọtara ọnụ otu ugboro n'ụbọchị. Ọ dabara adaba, ọ kachasị maka ndị ọrụ na ndị dọpụrụ uche.

Ọ bụrụ na dọkịta gwara Noliprel, otu esi ewere ọgwụ a tupu ma ọ bụ mgbe nri gasịrị bụ okwu dị ọkụ maka ọtụtụ ndị ọrịa.

Ntụziaka gọọmentị enyeghị azịza ya. Ọ na-egosi na ọgwụ kwesịrị ị shouldụ mmanya n’ụtụtụ.

Ndị dọkịta na-atụ aro iji ọgwụ tupu nri ụtụtụ. Ọ dị mma ị were mbadamba ndị ahụ n'otu oge. Mgbe ahụ ọ ga-ekwupụta nsonaazụ nke ọgwụgwọ ahụ ọ nweghị mmetụta ọ bụla agaghị enwe.

Maka usoro ọgwụgwọ ahụ, dọkịta ahụ na-ebu ụzọ depụta otu mbadamba ụbọchị kwa ụbọchị. Ma, ọ bụrụ na ọnwa agbanyeghị ọgwụgwọ ebidoghị nsonaazụ achọrọ, a na-atụpụta Noliprel Forte na usoro onunu ogwu nke 4 mg perindopril na 1.25 ebepamide. Mgbe ụfọdụ ndị dọkịta depụtara ọgwụ ndị ọzọ. Dịka ọmụmaatụ, a na-agbakwunye calcium antagonists. N'okwu a, usoro onodu ogwu a na-ebelata.

Ọ bụrụ na dose ahụ dị oke, a na-achọpụta mgbaàmà ndị a:

ọgbụgbọ na ọgbụgbọ
iro ụra
enweghị mmasị
anya ntughari
adịghị ike
bradycardia
ogwe
ịkụda mmụọ
ọsụsọ oyi
mbelata nke obara,
nkwụsị mmamịrị ma ọ bụ urination ugboro ugboro.

Ọ bụrụ na ihe iriba ama ndị dị otu a gosipụtara, ịkwesịrị ịkpọ ụgbọ ihe mberede. Ma mgbe ahụ dị gị mma, ị ga-eso dọkịta gị gbaa oge iji hazie usoro a ga-esi rụọ ya.

Nnabata n'oge ime

N’oge a na-eme atụmatụ ịtụrụ ime, amụghị nwa ka akwadoghị Noliprel.

Ọ bụrụ na nwanyị ejirila ọgwụ ndị dị otú ahụ na mbụ, ekwesịrị imecha ya ma gakwuru dọkịta iji nye ọgwụ ọzọ.

Emebeghị nnyocha banyere mmetụta nke ndị na-egbochi ACE na ụmụ nwanyị dị ime. Amabeghị nke ọma ọgwụ a si emetụta mmepe nwa ebu n’afọ.

Ya mere, a ga-akpachara anya. E kwuwerị, enwere ihe ize ndụ na ọgwụ ndị nọ n'ọrụ ọgwụ nwere ike imetụta ịkpụkpụ ọkpụkpụ, ọrụ nke akụrụ nwa amụrụ ọhụrụ. Ọzọkwa na-eme ka ohere nke hypotension arterial ike.

A na - egbochi ọgwụ a ara, maka na ọ na - egbochi ara, na --ebelata oke mmiri ara ara na nne na - eto eto. Na nzụlite usoro ị ofụ ọgwụ dị otú a, nwa nwere ike inwe hypokalemia, jaundice.

Oge ọgwụgwọ

Noliprel na - abụkarị ọgwụ a na - ejikarị agwọ ọbara mgbali elu.

A na-anabata ọgwụ ogologo oge, mana ọ ga - adị mma ka ịhapụ obere oge. Ma ọ bụghị ya, ọgwụ ahụ nwere ike imetụta ọrụ akụrụ na imeju.

Ogologo oge ị drinkụ Noliprel, doses - a ga-ekpebi nke dọkịta, nye ọnọdụ onye ọrịa.

A na - agọnye ọgwụ a n'ime ndị ọrịa nwere nnukwu akụrụ. Site na ọdịda akụrụngwa na-agafeghị oke, usoro onunu ogwu ekwesịghị ịbụ ihe karịrị otu mbadamba kwa ụbọchị.

Somefọdụ ndị ọrịa nwere nsogbu akụrụngwa arụ ọrụ mgbe ha na-a theụ ọgwụ ahụ, akara ụlọ nyocha nke ezughi oke nke akụkụ a na-apụta. N'okwu a, a kwụsịrị ọgwụgwọ ahụ. N’ọdị n’ihu, a na-ahapụ ya ka ịmaliteghachi ọgwụgwọ ngwakọta, mana n’usoro kachasị dị ala na obere usoro.

A naghị akwado ọgwụ maka Noliprel ogologo oge maka ọrịa ndị a:

angina pectoris,.
scleroderma,
hyperuricemia
ọrịa shuga mellitus
systemic lupus erythematosus,
ike hyperrophic cardiomyopathy,
aortic valve stenosis,
nkụchi obi na - adịghị ala ala.

Ọgwụ ahụ na-enyere aka ịnọgide na-enwe nrụgide n'ogo nke 130-140 / 80-90 mm. Hg. Art. na n'okpuru.

Yabụ, ihe ọghọm nke nkụchi obi, nkụchi obi na akụrụ oke na-ebelata. Ndị dọkịta achọpụtala ịdị irè nke ọgwụ ahụ.

Ndị dọkịta chọpụtara na ngwa ọrụ ahụ na-enye gị ohere idozi tonometer na oge anaghị ebute nsonaazụ. Imirikiti nsogbu na-ebilite na ndị ọrịa nwere oke ume mgbe ha na-ewere Noliprel metụtara eziokwu ahụ bụ na ndị ọrịa anaghị a theụ mbadamba ihe ndị ahụ n'ụzọ ziri ezi, agbaso ndụmọdụ ndị dibia na-aga.

Ndị ọrịa hypertensive na-ahụ na Noliprel dị ọnụ ala, enwere ike ịzụta ya na ahịa ọgwụ ọ bụla. Ma mgbe ụfọdụ ọgwụ anaghị ere. N'okwu a, a na-anabata analogues. Iji maa atụ, Co-perineva, Prestarium, Perindopril na Indapamide Forte, Co-prenes, Quinard, Mipril, Lysopres, Capotiazide, Iruzid. Onye ọzọ n'ọnọdụ kwesịrị ekwesighi bụ Ena sandoz, nke kwesịrị ekwesị maka ọgwụgwọ ọbara mgbali elu, nkụchi obi na-adịghị ala ala, yana mgbochi nke infarction myocardial.

Vidiyo ndị metụtara

Vidiyo a na-akọpụta ọgwụgwọ ọgwụgwọ maka Noliprel ọbara mgbali elu. Ha n tonye onye edere ya na onye ọ g doji ya:

N'ihi ya, otu n'ime ọgwụ ọgwụ ndị mejupụtara ọgwụ ọnụ n'oge a dị mma bụ Noliprel. Ọgwụ ahụ ji nwayọ ma mee ngwa ngwa mee ka nrụgide ahụ ike. Ọ dị na usoro dị iche iche. N'ihi nke a, ọ dị mfe karịa ịhọrọ usoro kachasị adaba. Ma ị -ụ ọgwụ nke onwe abụghị ọgwụgwọ. Dọkịta kwesịrị inye ọgwụ ọgwụ ma naanị mgbe nyochachara onye ọrịa ahụ.

Ọ na - ewepụ ihe ndị na - akpata nsogbu mgbali
Normalizes nrụgide n'ime nkeji iri mgbe nchịkwa

Noliprel Forte: ihe mejupụtara na ụdị ntọhapụ

Iji mezie nrụgide ahụ, a na-eji ọgwụ nke mmetụta dị iche iche eme ihe. N'ụzọ bụ isi, ndị a bụ ọgwụ diuretics - na - ewepu mmiri mmiri na mmiri sodium gabigara n’ọbara, na --ebelata ego ya ma na - eme ka ọbara na - erite. Ejikọtara ha na ọgwụ ndị ihe ha mere bụ iji gbochie ọrụ enzyme ahụ nke na-eme ka angiotensin nke m bụrụ angiotensin II.

Site na mbelata mgbali akụrụ, a na - emepụta prorenin, nke, mgbe ọ banyere na plasma ọbara, na - agbanwe ka ọ bụrụ renin, na - ejikọ ya na angiotensinogen, na - akpụ angiotensin nke mbu. N'otu oge ahụ, akwara ọbara na-adịzi warara, ọnụọgụ obi na-agbadata, usoro ọmịiko nke etiti, nke na-ahụ maka nrụgide, na-enwe obi ụtọ, a na-emepụta aldosterone, nke na-ejigide nnu na mmiri, na-abawanye ibu ahụ na sistem. Usoro a na-amanye gị ị drugsụ ọgwụ mgbochi ọnụ ugboro ugboro.

Noliprel A Forte (Noliprel Forte) - ngwa ọrụ ọhụụ nke ijikọ ọrụ: diuretic na inhibitory nke angiotensin-enzyme na-agbanwe. Na-eme ka ịgwọ ọrịa dịkwuo irè, na-ebelata mmetụta na nsogbu.

Ogwu a dikwa n ’ibelata nke ihe ndi n’eme ka akpo Noliprel A. E gosipụtara ya maka ndị ọrịa na-agaghị ekwe omume iji ọgwụgwọ na mmelite kwalite ọgwụgwọ.

Ọgwụ nwere akụkụ abụọ na - arụ ọrụ:

ebepamide (1.25 mg),
perindopril arginine (5 mg).

sodium carboxymethyl stachi (2.7 mg),
silica (0.27 mg),
lactose ka monohydrate (71.33 mg),
magnesium stearate (0.45 mg),
maltodextrin (9 mg).

Emere ọgwụ a n'ụdị convex oval white white. Enyere ya na karama roba na onye na-enye ihe ya ma obu mkpuchi ya nke pcs iri na ano ma obu iri ato.

Actiongwọ ọgwụ

Indapamide na Perindopril bụ ọgwụ ndị na - egbochi ọgwụ nke otu dị iche iche, mana ejiri nke ọma jikọtara ya na usoro ọgwụgwọ siri ike. Ihe ndị ahụ na-emekọrịta, na-eme ka ibe ha na-emekọ ihe, na-enyere aka belata usoro onunu ogwu ma belata nsonaazụ.

Ihe di na sulfonamides bu ihe diuretic. Site na igbochi nnabata nke sodium ion n’ime ọbara, ọ na - ewepụ ha ozugbo akụrụ na plasma na - abawanye, na - amụba urination. Ime ihe dị otú ahụ na-enwe ike belata nrụgide nke mmiri mmiri n'ime arịa, mee ka ọbara na-agbapụta, na-ebelata nkụchi obi.

Indapamide na-ebelata ike nke akwara ozi vaskụla n’ọrụ nke angiotensin II. Na mgbakwunye, ihe ahụ na -ebelata mkpụkọ calcium n'ime ọbara n'ihi mpụta ya na mmamịrị ahụ, nke na-ebelata pasent% nke ihe ndị na-abanye na myocardial anụ ahụ.

Calcium na-eme ka mọzụlụ na-esite ike, nke a na-eduga n'ịba ụba obi na ịrị elu.

Indapamide na-ebelata ọgbọ nke ikuku oxygen, nke na-ebute ịka nká nke anụ ahụ na ọdịdị nke neoplasms.

A na-etinye ngwa ahụ ngwa ngwa site na ijikọ ya na protein protein, elastin muscle. Ọ na-abụkarị akụkụ akụrụ. Ihe dị ka 30% nke imeju na-ewepụ n'ụdị metabolites ma ọ bụ ọnọdụ mbido.

Indapamide nwere mmetụta ịdabere na dose, yabụ, edepụtara ya maka ọgwụgwọ.

Perindopril

Akụkụ na-egbochi ọdịdị nke angiotensin II - vasoconstrictor dị ike. O nwekwara mmetụta ndị ọzọ na-emetụta n'ụzọ dị mma maka mmezi nke ndị na - egosi ọbara mgbali elu siri ike:

na-ebelata aldosterone mmepụta,
na-abawanye ọrụ renin,
na-eme ka ọnụego obi na-agbanwe na-agbanwe agbanwe.

Perindopril na-eme ka ọbara na-aga n'ihu, na-ebelata ibu dị na akwara obi, na-ebelata ihe ize ndụ nke nkụchi obi, na-egbochi mmepe nke hyperplasia ma ọ bụ hypertrophy nke akwara anụ ahụ nke obi, na-arụ ọrụ cardio- na mmetụta angioprotective.

Iji wedata ọbara mgbali elu, a na-ewere ihe ahụ otu oge - nsonaazụ ahụ na-apụta mgbe awa anọ gachara wee ruo otu ụbọchị - yana usoro ahụ. N'iji ya kwa ụbọchị, a na-egosipụta ọgwụgwọ ọgwụgwọ akpọrọ otu ọnwa ka ọ na-adịgide ruo ogologo oge.

Ngwa maka oge nke ọnwa 6 ma ọ bụ karịa belata ibu na obi na arịa ọbara ma na-abawanye ntachi obi na ndị ọrịa nwere nkụchi obi. Perindopril abụghị onye na-eri ahụ.

Mgbe ejiri ya, a na-etinye ya ngwa ngwa, na-ejikọ ya ike na protein protein, imeju na-agbaze ya, akụrụ na ahụ.

Edere ọgwụ maka ọgwụgwọ nke ọbara mgbali elu dị mkpa - usoro a (3-4 ugboro kwa ụbọchị) mmụba karịa 140/90. Otutu mgbe achoputara n’ulo ndi oria n’agbata 35 ruo afọ 40 n’enweghi ebumnuche akpọrọ

Oge nchịkwa ọgwụ "Noliprel Forte" na mbido ọrịa ahụ nwere ike ịhazi oke nrụgide. N’ime ọnọdụ dị oke njọ, nke atọ, mgbe mgbali ọbara gbagogo na 180/110, ọ na-eme ka ọ dị ala, belata ohere ọbara ọgbụgba na nkụchi obi.

Ekwuputala ọgwụ a ka o jiri mee ihe na ndị ọrịa nwere ọrịa ọbara mgbali elu n’otu oge yana ụdị ọrịa shuga 2 dị ka ụzọ isi chebe nsogbu nke ọrịa nkwonkwo.

Noliprel Forte ọgwụ

Ọgwụ dị irè n'ọgụ megide ọbara mgbali elu. N'ihi ihe mejupụtara ọgwụ ahụ, ngwakọta na-aga nke ọma nke ihe ndị mejupụtara ya (perindopril, ebepamide), Noliprel na-eme ka ọbara mgbali ngwa ngwa ma wepu oke mmiri ahụ. Mmetụta ọgwụgwọ kwụsiri ike nke Noliprel na-apụta mgbe izu 3-4 gachara site na mbido ọgwụgwọ, esoghịkwa ya bụ tachycardia. Edere ọgwụ ahụ maka ọgwụgwọ n'ụlọ, yana dọkịta na-enyocha ya mgbe ụfọdụ iji dozie usoro ahụ.

Ngwakọta nke Noliprel

Ọgwụ ahụ dị na mbadamba ọcha. Noliprel nwere ọtụtụ ụdị nwere usoro dị iche nke ihe ndị bụ isi: perindopril, ebepamide. Ihe ngosi nke ogwu a ka egosiputara n’elu tebụl:

Perindopril ịta, na mg

Rationta ihe ebepamide, na mg

lactose monohydrate, celclose microcrystalline, siliki, hydrophobic colloidal, arginine (gụnyere n'ụdị ntọhapụ ya na prefix “A”)

Noliprel A Bi-Forte

Noliprel A Forte

Omume ọgwụ

Noliprel ọgwụ bụ ngwakọta nke ihe abụọ bụ isi nwere ihe nke aka ha, nweekwa ọtụtụ mmetụta:

Perindopril. Mbelata ọbara mgbali elu ka ọ dị n'ọbara, na - ebelata nguzogide n'ime akwara ọbara, na - eme ka mgbidi akwara dịkwuo nkọ, na - eme ka akwara obi kwụsie ike, na - ebelata mgbatị aka ekpe, na - ebelata ibu dị ukwuu na akwara obi.
Indapamide. Ọ na - ewepụ oke mmiri site na akụrụ, nwere mmetụta diuretic na vasoconstrictor.

Ihe ngosi maka ojiji

Mbadamba ụrọ Noliprel ka eji eme ihe maka naanị ihe ngosipụta maka ọgwụgwọ - ọbara ọgbụgba dị oke mkpa. Ọrịa a bụ ọrịa nke akwara gland, akụrụ. Agbanyeghị, dị ka ntuziaka ahụ si dị, enwere ike ịkọ ọgwụ ahụ maka ebumnuche prophylactic maka ọgwụgwọ nke ọrịa vaskụla na ndị ọrịa nke otu ndị pụrụ iche (ọbara mgbali elu, ụdị shuga mellitus II).

Noliprel Forte

Akụkụ dị mma nke ọgwụ ahụ bụ na a ga-a onceụ ya otu ugboro n'ụbọchị. Nke a dabara adaba maka ndị agadi, bụ ndị na-ata ahụhụ mgbe niile ichefu. Oge kacha mma ị takeụ ọgwụ bụ ụtụtụ. Iri mbadamba 1 ga-elo (anaghị ata ata, anaghị ekewa abụọ.) Tupu nri, drinkụọ ọtụtụ mmiri mmiri. A na-egosipụta ọrụ nke mbadamba ahụ awa 2-5 mgbe ejiri ya wee dịgide ruo awa 24. Mgbe otu ọnwa na ọkara gasịrị ị drugụ ọgwụ ahụ, dọkịta ahụ na-ahazi usoro ịgwọ ya.

N’oge ime ime

Amachibidoro iji ọgwụ a eme Noliprel megide nrụgide amachibidoro ya n’oge ị na-azụ nwa na inye nwa ara. Mgbe ị na-eme atụmatụ ma ọ bụ na-atụrụ ime, a ga-akwụsị ịgwọ ọrịa antihypertensive ozugbo. Ihe Noliprel nọ n'ọrụ nwere ike imetụta mmepe nke nwa ebu n’afọ, na-akpata:

gbasara akwara
mmiri ọmụmụ mmiri,
na-aka obere ọrụ gbasara nwa,
oge n'ime mmepe nwa ebu n'afọ metụtara fetotoxicity,
jiri nwayọ guzobe ọkpụkpụ nke isi nke nwata ahụ,
ọbara mgbali ike.

N'oge a na-enye nwa ara, Noliprel kwesịrị ịkwụsị. Ihe mejupụtara ọgwụ ahụ na-ebelata oke mmiri ara ara na arara ara. Na mgbakwunye, Noliprel nwere ike imetụta ahụike nwa ahụ n'ụzọ dị njọ, na-akpata jaundice ma ọ bụ hypokalemia. Ọ bụrụ na ọgwụ dị mkpa maka ahụike nne ya na enweghị ihe ọ bụla ga-eji dochie ya, a ga-enwerịrị nwa ahụ ka ọ na-ebugharị nri nwa oge.

Na nwata

A naghị akwado Noliprel maka ọgwụgwọ ụmụaka na ndị nọ n'afọ iri na asatọ. E guzobebeghị nsonaazụ, nsonaazụ yana arụ ọrụ nke ọgwụ ahụ n'ahụ ahụ ụmụaka. Ileghara contraindication a anya nwere ike ibute ọrịa na ahụike onye ọrịa yana ụlọ ọgwụ ozugbo iji weghachite akara dị mkpa nke onye ọrịa.

Usoro ire na ebe nchekwa

N'aka ọgwụ ka erere ọgwụ ahụ. Enweghị ọnọdụ nchekwa pụrụ iche, ịkwesịrị idobe Noliprel ka ọ ghara iru ụmụaka nwere okpomọkụ na-erughị ogo 30. Ndụ ndụ nke ọgwụ adịghị ihe karịrị afọ 3.

Nyere oke ego nke Nolirel na otutu contraindications, enwere ike dochie ọgwụ analogues ọzọ. Mkpebi ịhọrọ otu ngwá ọrụ iji belata ọbara mgbali kwesịrị ka dọkịta mee. Njikọ nke ịga nke ọma nke ebepamide na perindopril na-arụ ọrụ n'ime ọgwụ ndị dị:

Ko-Perineva,
Perindopril-Indapamide Richter,
Perindapam,
Co Parnawel
Indkwụ ụgwọ
Noliprel A
Perindopril-Teva na Indapamide,
Phonespres
Iruzid,
Ekpo
Dalneva.

Ntụziaka maka iji ọgwụ ahụ

Dị ka o kwesịrị, usoro ịgwọ ọrịa na nke a kwesịrị ịbụ nke ọ bụla, ebe ọ dabere afọ na ọnọdụ onye ọrịa ahụ, yana ọrịa chọpụtara na ya. Agbanyeghị, enwere usoro ọgwụgwọ a tụrụ aro n'ozuzu yana iwu aka. A na-ewere mbadamba Noliprel n'ụtụtụ - n'ụzọ dị otú a ga - apụta na ọ ga - apụta ngwa ngwa ma ọ ga - adịgide karịa, mgbali elu agaghị egbochi ọrụ ọ bụla.

Maka onu ogugu, a dụrụ ndị okenye ọdụ ka ha were otu mbadamba ụbọchi kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, dọkịta, nwere ike ịgbanwe dose ma ọ bụ usoro.

Ọgwụ "Noliprel forte": contraindications

Na mgbakwunye, ọrịa imeju na hypokalemia na-emetụtakwa contraindications. A machibidokwa ndị ọrịa nwere ọrịa akụrụ siri ike. Ma, n'ezie, a naghị akwado ọgwụ ahụ maka ụmụaka na-erubeghị afọ 18. Ma ebe ngwaahịa a nwere lactose monohydrate, enyeghị ya iwu maka ndị na-arịa ụkọ lactose na ụfọdụ ọrịa ndị ọzọ metụtara metabolism na-akpata ike.

Ọ bụ ya mere ị ga-eji chefuo na naanị dọkịta ga-edenye ọgwụ a ka ọ nwatasịrị nsonaazụ ule na ọmụmụ. Ọ bụrụ na enwere ọgwụ mgbochi, nsonaazụ ọgwụgwọ nwere ike ibute ahụike yana ndụ.

Mmeghachi omume na-adịghị mma

N'oge ụfọdụ, ọgwụ na - eduga n'ịmebi sistem iku ume - ụkwara akọrọ, bronchospasm, rhinorrhea nwere ike ime. N'ọnọdụ ndị a na-adịghị ahụkebe, iji ọgwụ ahụ nwere ike ibute angina pectoris, arrhythmias, ọrịa strok, nkụchi obi, nkụchi akwara.

Mgbe ụfọdụ enwere ọgbụgbọ, ọgbụgbọ, ọnya ọgbụgba, akpịrị na-akpọ nkụ. Ọ dịkarịghị ala, ọgwụgwọ na-eduga na mmepe nke ọrịa pancreatitis ma ọ bụ jaundice.

Ozi ndi ozo

Ọ dị mma ịmara na ọgwụ nke mbụ nke ọgwụ ahụ nwere ike ịkpalite mbelata nke ọbara mgbali elu - ọ dịghị mkpa ịtụ ụjọ, nke a bụ ihe nkịtị, karịsịa na ụbọchị ole na ole mbụ. Mana onye ọrịa dị otú ahụ kwesịrị ịnọ n'okpuru nlekọta nke ndị ọrụ ahụike mgbe niile.

Na mgbakwunye, ọ dị mkpa iji nyocha site n'oge ruo n'oge n'oge ọgwụgwọ - nke a na-enyere aka nyochaa ọkwa nke creatinine na potassium n'ime ọbara, ebe ọ bụ na ịhapụ ụzọ dị iche iche ga-esi kwe omume n'okpuru ọgwụ.

Ndị dọkịta adịghịkwa atụ aro ịkwọ ụgbọala n'oge ọgwụgwọ, jiri usoro dị iche iche na-achọ itinye uche kachasị na nzaghachi ngwa ngwa. Tupu ịmalite ọgwụgwọ, jide n'aka ịgwa dọkịta gị banyere ọgwụ ị na-a ,ụ, ebe ọgwụ Noliprel Forte na ọgwụ ndị ọzọ nwere ike ịdị ize ndụ.

Nyocha Ndị Ahịa

N'aka nke ọzọ, ọgwụ "Noliprel forte" nwere ụfọdụ ọghọm. Iji bido, ọ dị mma ịlele ọnụ ahịa ya - ọnụahịa a adabaghịrị onye ọ bụla mma, ọkachasị mgbe ọ gbasara usoro ọgwụgwọ ogologo oge. Na mgbakwunye, ụfọdụ ndị ọrịa tookụrụ ọgwụ ahụ ogologo oge (ọnwa 2-3) mepụtara nsonaazụ na-adịghị enye obi ụtọ - ntutu. Na ọnụnọ nke ụdị mmebi ahụ, ị kwesịrị ịgakwuru dọkịta ozugbo: ịnwere ike ịchọ mmekorita nke Noliprel (dịka ọmụmaatụ, Enap N). Site n'ụzọ, ị nwere ike ịzụta ngwaahịa nwere nnukwu ihe mejupụtara ọgwụ ahụ (perindopril na ebepamide) - iwere ha ga - enyere aka mezuo otu mmetụta ahụ, mana ihe ize ndụ nke isi nkwọcha ga-ebelata.

Usoro ọgwụgwọ

A na-atụ aro ị takeụ ọgwụ ahụ 1 mbadamba ụtụtụ tupu nri ụtụtụ. Otu uzo Noliprel Forte zuru ezu iji nọgide na-enwe ọgwụgwọ ọgwụgwọ ụbọchị niile.

E gosipụtara ndị ọrịa nwere ọrịa mellitus, akụrụ ma ọ bụ ọrịa hepatic ịmalite ọgwụ na ọgwụ "Noliprel A".

Ọ bụ dibịa a na-ahụ maka ịkwụ ụgwọ na usoro maka ị andụ ọgwụ a. Ọ bụrụ na a na-agbaso ntuziaka niile, ihe ọghọm nke nsogbu na mmeghachi omume na-adịkarị ala, yana ịdị mma nke ọgwụgwọ kachasị.

N'ọnọdụ ụfọdụ, ọ bụrụ na ọ gaghị ekwe omume ịhọrọ usoro ịageụ ọgwụ, a na-eji ọgwụ monocoponent dochie ọgwụ ahụ ma ebepamide na perindopril dị n'otu.

Mmeghachi omume ọjọọ

Mmeghachi omume na-adịghị mma nke anụ ahụ anaghị eso usoro ọgwụgwọ. Ọ bụrụ ngbanwe onodu na-ebute oke mgbakasị ahụ ma ọ bụ ihe iyi egwu na ndụ na ahụike, jide n'aka ịgwa dọkịta gị. Ọ ga-edozi ọgwụ ma ọ bụ dochie ọgwụ ahụ.

Kachasị mkpesa ndị ọrịa bụ:

ihe mgbu intracranial, dizzness,
ngosipụta nke mpụga nke allergies - hyperemia, urticaria, itching, peeling,
ọdịdị nke tinnitus, ọgba aghara a na-ahụ anya,
ihe omume nke hyporat orthostatic bụ mmetụta na-esoghị,
ịba ụba nke akpụkpọ ahụ azụ na akpịrị, ụkwara,
adighi ike, na aru ike.

Ihe ọghọm dị ka ụra na-ezughị ike, arrhythmia, tachycardia, edema, ọdịdị nke mmeghachi omume nfụkasị ahụ, ịatingụ iyi dị ukwuu abụghị obere.

N'ihi mgbanwe nke ịta ọbara, ọgwụ nwere ike imetụta arụmọrụ nke ihe ndị dị n'otu n'otu. Ya mere, a na-atụ aro ime nyocha nke ime ụlọ ya mgbe niile.

Ọgwụ "Noliprel Forte" nwere ọgwụgwọ ọgwụgwọ egosipụtara na ọgwụgwọ nke ọbara mgbali elu.

N'ime ndị ọrịa na-a theụ ọgwụ ahụ, a chọpụtara na:

mmetụta ọgwụgwọ na-adịgide adịgide mgbe izu ụka 2-3 gachara,
mbelata na ogo nke mgbatị ume aka ekpe ume hypertrophied,
mmelite nke ọnọdụ izugbe na ọdịmma,
ịgba ọbara mgbali elu zuru oke n'ịgwọ ọkwa mbụ nke ọbara mgbali elu.

N'izugbe, a na-anabata Noliprel n'ụzọ dị mfe, ma enwere ihe dochie anya ọgwụ ọzọ nke ime ihe yiri nke ahụ.

Nwere ike ịzụta ọgwụ n'ụlọ ahịa ọgwụ. A na-ewepụta ya naanị na ndenye ọgwụ. A na-anabata nnabata ma ọ bụrụ na onye ọkachamara na-emekọ ihe. Ọnụ ego ọgwụ dị 680 rubles n'otu ngwugwu 30 PC.