Mpempe akwụkwọ Zokor forte: nyocha ndị ọrịa na ihe ngosi maka ojiji

A na-enweta ya n'ụdị mbadamba, nke a na-ekpuchi. 10 mg mbadamba simvastatin, nwee àgwà na-acha edo edo dị mma, ọdịdị dị larịị n'otu aka, n'aka nke ọzọ enwere ihe osiseMSD 735«.

Mbadamba 20 mg simvastatinnwere agba aja aja na agba aja aja, oval dikwa nma n’otu aka, n’aka nke ozo enwere ihe osise ”MSD 740«.

Zokor Forte dị n'ụdị nke mbadamba pink, na-enwe ọdịdị dị mma oval n'aka nke ọzọ, n'akụkụ nke ọzọ enwere ihe osiseMSD 749«.

Ọpịpịa ahụ nwere mbadamba iri na anọ, n'ime igbe a nwere ike inwe otu ma ọ bụ abụọ na blisters.

Omume ọgwụ

Ogwu ahu nwere akpukpo ahu hypolipidem. Mbadamba ahụ nwere ihe eji arụ ọrụ simvastatin, na usoro nke hydrolysis na-agbanwe ka ọ bụrụ ogige arụ ọrụ. Metabolite nke simvastatin na-egbochi enzyme HMG-CoA reductase. Enzyme a na - ekere òkè na oge mbụ nke biosynthesis. cholesterol.

N'ihi nke a, n'okpuru mmetụta Zokor, a na-ebelata ọkwa cholesterol n'ime ahụ, yana ọdịnaya nke cholesterol, nke a na-ejikọ na lipoproteins dị ala na nke dị ala. A na-ebelatakwa plasma cholesterol nke triglycerides.

N'otu oge, mgbe ị na-ewere simvastatin, ọkwa cholesterol, nke a na-ejikọ na lipoproteins dị elu, na-abawanye nke ukwuu.

Achọpụtara irè ọgwụ a nwere ụdị dị iche iche. hyperlipidemia, ọkachasị na heterozygous, ezinụlọ, ndị na-abụghị ezinụlọ. Ọzọkwa, ọgwụ dị irè na ụdị hyperlipidemia agwakọta na ihe omume ahụ nri ezughị inye onwe gị ọgwụ plasma.

Ọnụ ọgụgụ nke lipids na plasma na-ebelata ụbọchị 14 ka ịmalite ọgwụgwọ. N'okwu a, a na-achọpụta ụkpụrụ kachasị elu na izu isii nke ọgwụgwọ. Ọzọkwa, mgbe ị na-a theụ ọgwụ ahụ, echekwara nsonaazụ a.

Mgbe emechara ọgwụgwọ a, were nwayọ gosipụta ihe cholesterol zuru ezu na plasma laghachi na ụkpụrụ mbụ, nke a chọpụtara tupu ị takingụ ọgwụ.

Pharmacokinetics na pharmacodynamics

Ntinye uche nke kachasị elu nke simvastatin metabolites n'ime ọbara ka amaara awa 1.3-2.4 mgbe mmadụ mechara otu ọgwụ ahụ. A na-etinye ihe dị ka 85% simvastatin ọnụ a na-ahụ n'ime ahụ.

Mgbe nhazi nke ime, jiri ya na akwara ndị ọzọ, a ga-ahụta ọkwa dị elu nke ihe nọ n'ọrụ na imeju.

N'ime ụzọ izizi nke n'ọbara, imeju simvastatin bụ metabolized, emesịa mịpụ ọgwụ ahụ na metabolites ya n'ahụ.

Iri nri ozugbo ị takingụsịrị ọgwụ ahụ anaghị emerụ ọgwụ ọgwụ. Site na usoro ọgwụgwọ ogologo oge, simvastatin anaghị agbakọ na anụ ahụ.

Ihe ngosi maka ojiji

Ohere Zokor gosipụtara n’etiti ndị so n’ìgwè nwere nnukwu nsogbu mmepe akwara obi n'agbanyeghị lipids ọbara. Ndị otu ahụ nwere nsogbu gụnyere ndị nwere ọnọdụ ọnụọgụ abụọ:

ọrịa ụbụrụ, gụnyere ọria aru(akụkọ)
ọrịa shuga mellitus(ọgwụ ahụ nwere ike igbochi ngosipụta nke nsogbu ọgbụgba na akwara ma belata mkpa ịmụgharị na mbepụ nke akụkụ ala).
pathology nke nsogbu ọbara ọgbụgba.

A na-eji ọgwụ ahụ agwọ ndị mmadụ ọrịa nyocha nke ọrịa obi na akwara na hypercholesterolemia. N'okwu a, Zokor nwere ike igbochi mkpughe ọnya anụ ahụ atherosclerotic na obi, mmepe nke nsogbu ndị ọzọ.

Edekwara Zokor maka ndị ọrịa toro eto n'ọnọdụ ndị a:

ndị mmadụ nwere oke ọkwa n'ozuzu ha cholesterol, apolipoprotein Byana cholesterol, nke ejikọtara ya na lipoproteins dị ala, yana nri,
ya na hypertriglyceridemia,
yana cholesterol dị ala nke lipoproteins dị elu, nke jikọtara ya na hypercholesterolemia bụ isi mgbe ị na-eri nri,
ya na ụdị hypercholesterolemia nwere homozygous na usoro ọgwụgwọ na nri ndị ọzọ.

Ihe ngbanwe

Zigor zuru oke maka iji Zokor bụ:

na -akpata nri na metabolism nke lactose,
ọrịa nke imeju na-akpata, mmụba dị ukwuu na nke na-arịwanye elu na ọnụ ọgụgụ transaminases nke esighi n'aka,
mmadu anabataghi yab
afọ ime na nri afọ,
afọ ruru 10.

Ikwe zigidere iji zokor bụ:

N'ọnọdụ ndị dị otú a, a na-eji ọgwụ elebara ọgwụ anya.

Usoro onunu ogwu na ochichi Zokor forte

Tupu na mgbe usoro ọgwụgwọ ahụ, a ga-ahụrịrị usoro hypocholesterol. N'ime, na ụdị ọgwụ mbụ 10 mg otu ugboro, na mgbede, yana ogo hypercholesterolemia dị nro dose mbụ bụ 5 mg, ma ọ bụrụ na ọ dị mkpa, a na-eji nwayọ dose ahụ abawanye na oge nke izu anọ. Site na hypercholesterolemia familial udiri ubochi - 40 mg otu ugboro, na mgbede ma ọ bụ 80 mg / ụbọchị (na-ekewa n'ime usoro 3 - 20 mg n'ụtụtụ, 20 mg n'ehihie, 40 mg na mgbede). Site na ọrịa obi dose mbụ bụ 20 mg, otu ugboro, na mgbede, ọ bụrụ na ọ dị mkpa, ọ na-eji nwayọ nwayọ na oge nke izu anọ ruo 80 mg.

Mmetụta dị n'akụkụ Zokor forte

Isi ọwụwa, dizzness, asthenia, dyspepsia, hepatitis / jaundice, pancreatitis, cramps muscle, myalgia, myopathy, rhabdomyolysis, paresthesia, neuropathy peripheral, anaemia, alopecia, skin fashish, pruritus, hypersensitivity reaction (urticaria, hyiti , mkpụmkpụ ume, oke ịba, angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, ogbu na nkwonkwo, ọrịa ogbu na nkwonkwo, ESR, ụbara thrombocytopenia, eosinophilia), nnabata ụlọ nyocha (mmụba ụlọ ọrụ nke trans a na-akpọ alkaline phosphatase, gamma-glutamyltranspeptidase, ọkpụkpụ akwara creatine phosphokinase, mgbanwe na ule ọrụ imeju).

N'ọtụtụ ọnọdụ ama ama nke ịdoụbiga mmanya ókè (oke kacha - 450 mg), enweghị akara ma ọ bụ mmetụta ọ bụla akọwapụtara. A na-eji ọgwụgwọ Symptomatic eme ihe.

Ọ dị ala na-enwe mmetụta nke ọgwụ antumagagula coumarin. Mgbe ejikọtara ya na cyclosporine, itraconazole, ketoconazole, ọgwụ fibric acid, niacin, erythromycin, clarithromycin, ndị na-egbochi nchebe, nefazodone, ihe ize ndụ nke rhabdomyolysis na-abawanye. Ekwesịrị ịkwụsị ọgwụgwọ ma ọ bụrụ na enyo myopathy ma ọ bụ enyo enyo.

Tupu ịmalite ọgwụgwọ, a na-atụ aro ka ọ duzie (ma megharịa ya oge ụfọdụ) banyere ọrụ imeju. Mgbe ogo nke transaminases bidoro gafere oke iwu kachasị elu ugboro atọ, a na-akagbu ọgwụ ahụ. Edere ya n’uche nye ndị ọrịa na-a abuseụbiga mmanya ókè na / ma ọ bụ nwee akụkọ ọrịa ọrịa imeju.

Ekwela ka ụmụaka ghara iru ya.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Nwere ike ịtụle analogues nke Zokor forte na edemede ndị dị mkpa, ma dị ọnụ ala ma dịkwa ọnụ karịa:

Ngwọta a dịịrị otu "Atherosclerosis". Ọzọkwa na otu a gụnyere: Dipromonium, Brilinta, Benzaflavin

Ngwá ọrụ a bụ nke otu "ọrịa ọrịa ụbụrụ." Ọzọkwa na otu a gụnyere: Actovegin itinye uche, NICOTINIC ACID-VIAL, Kapilar

Nsonaazụ

Effectsdị mmetụta ndị a nwere ike ịda mgbe a na-agwọ ndị ọrịa nwere Zokor:

ahụ erughị ala na mgbu afọ, ịmịchapụta, nkwarụ ọgbụgba,
isi ọwụwa mmetụta adịghị ike n'ozuzu ya anaemia,
anya ntughariogwe nsogbu neuropathy akụkụ, paresthesiancheta na nsogbu ụra,
akpukpo aru, alopecia, itching.

N'ọnọdụ ndị a na-adịghị ahụkebe, mepụtara myopathy, rhabdomyolysisn'ime usoro ị na-ewere simvastatin, yana mbelata nke ọrụ imeju. Edere okwu banyere mmepe nke myalgia. N'izugbe, ndị ọrịa na-anabata Zokor nke ọma.

Site na hypersensitivity na ọgwụ ahụ, ụbụrụ Quincke, vasculitis nwere ike ịmalite dermatomyositisthrombocytopenia, eosinophilia, ogbu na nkwonkwo, Mmụba ESR, arthralgia na ndị ọzọ

Ntụziaka maka iji Zokora (Usoro na usoro onunu ogwu)

Ntụziaka maka iji Zokora na-enye na onye ọrịa ahụ na-ewere ọgwụ ahụ ọnụ, n'agbanyeghị nri ahụ. Mustbọchị ọ bụla nke ọgwụ a ga-emerịrị na mgbede, ọ dịghị mkpa ịkewa ya n'ọtụtụ usoro.

Ihe dị ka simvastatin kwa ụbọchị bụ 5-80 mg. Iri ihe karịrị 80 mg nke simvastatin kwa ụbọchị ekwesịghị iwere ya.

Dọkịta na-ahọrọ ọgwụ a ga-enye ya, ebe ọ na-eburu n'uche ọ̀dịdị lipids dị na plasma mgbe niile. A na-ahazi ọgwụ ahụ karịa otu ugboro kwa izu anọ.

Maka ebumnuche mgbochi na ọgwụgwọ Ọrịa ụbụrụ Ischemic na-emegide usoro nri, ị doseụ ọgwụ kwa ụbọchị nke 40 mg nke Simvastatin bụ nke enyere n’iwu.

Na hypercholesterolemiaọ bụrụ na usoro ọgwụgwọ nri anaghị enye nsonaazụ achọrọ, a na-atụkwa ọgwụ kwa ụbọchị nke 20 mg nke simvastatin kwa ụbọchị. Ọ bụrụ na ọ dị mkpa ịbelata ihe dị n’ime afọ plasma na 45% ma ọ bụ karịa, ọgwụ mmalite kwa ụbọchị nwere ike ịbụ 40 mg.

Ọ bụrụ na onye ọrịa nwereụdị hypercholesterolemia na-agba ume obere oge, mgbe ahụ, enwere ike belata dose kwa ụbọchị ruo 10 mg.

Dọkịta na-ekpebi ọgwụ dị mkpa iji mee ọgwụ ahụ, na-elele ọkwa nke lipids ma nyochaa ịdị irè nke ọgwụ ahụ mgbe mmalite ọgwụgwọ. Ọ bụrụ n’izu anọ ebidochara ọgwụgwọ, a anaghị ahụ nsonaazụ a na-atụ anya, na nke a, a na-abawanye ọgwụ nke ọgwụ ahụ, ma jiri nwayọ, ruo mgbe achọpụtapụtara mmetụta akpọpụtara.

Na Hyzycholesterolemia homozygous familial na-emegide usoro nri na ụzọ ọgwụgwọ ọzọ, ịmalite ọgwụ nke Zokor kwesịrị ịbụ 40 mg kwa ụbọchị, ma ọ bụ 80 mg nke simvastatin ka edepụtara na ọnọdụ a na-ewere 20 mg ọgwụ ahụ n'ehihie, yana 40 mg na mgbede.

Ndị na-eto eto na hyzycholesterolemia homozygous familial na-ebu ụzọ depụta 10 mg nke ọgwụ kwa ụbọchị. Ọgwụ kachasị elu kwa ụbọchị maka ọgwụ maka ndị nọ n'afọ iri na ụma bụ 40 mg.

Mmekorita

A na-ahụta nsonaazụ dị mma akpọrọ site na iji otu oge Zokor na usoro nke bile acid.

Site na nhazi oge nke fibrates, cyclosporine na ọgwụ dị ala nke niacin kwa ụbọchị, ị gaghị ewe karịa 10 mg ọgwụ ahụ. Zokor.

Ndị mmadụ na-anata Verapamil na Amiodaroneekwesịghị ị drinkụ ihe karịrị 20 mg nke simvastatin kwa ụbọchị.

Simvastatin anaghị eme ihe n'ọrụ enzymatic nke CYP3 A4.

Site na nlekọta nke ọgwụ ndị a na-eme n'otu oge na-egbochi ọrụ CYP3 A4, enwere ike ịmalite myopathy na rhabdomyolysis na ndị na-ewere simvastatin. Ọ dịghị mkpa ijikọ Zokor na itraconazole, Erythromycin, nefazodone, ketoconazole, telithromycin.

Ohere inweta myopathy na rhabdomyolysis na-abawanye mgbe ị na-ewere amiodarone, diltiazema, gemfibrozil, cyclosporine, niacin, fusidic acid, danazole, verapamil, fibrate.

N'okpuru nduzi nke Zokor na-eme ka mmetụta ahụ dịkwuo elu coumarin anticoagulants.

Mgbe ị na-a moreụ ihe ọ 1ụ juiceụ mkpụrụ osisi grape karịa 1 kwa ụbọchị, a na-achọpụta mmụba dị ukwuu na mkpokọta plasma nke simvastatin, nke na-eme ka ohere nke rhabdomyolysis nwee ike.

Mgbe ị na-ewere 20-40 mg nke simvastatin kwa ụbọchị, a na-enwe mmetụta ahụ coumarin anticoagulants. N’ihi nke a, ọghọm dị n’ọbara na-abawanye.

Zokor Forte - ọgwụ maka ọgwụgwọ ọrịa obi na akwara na atherosclerosis

Zokor Forte bụ otu n’ime ọgwụ kachasị aga eji rụọ ọrụ iji gwọọ ọrịa obi na akwara na ọrịa.

A na-egosi ọgwụ a n'ụdị mbadamba dị mma, na ndabere ya bụ simvastatin ihe hypolipedimic.

Ojiji nke ogwu ahu dika ntuziaka ndi a si ebelata oria onwu n’ile ndi mmadu oria obi agha.

N'ọtụtụ oge, were mbadamba Zocor Forte otu ugboro kwa ụbọchị na ego ole dọkịta nyere.

Tupu ịmalite usoro ọgwụgwọ, ọ dị mkpa ka ị mara atụmatụ niile nke ọgwụ a, yana ichebara mmetụta na contraindications dị iche iche enwere ike.

Kedu ka Zokor Forte si eso ọgwụ ndị ọzọ emekọrịta?

Tupu ịmalite iburu mbadamba Zokor Forte, ị kwesịrị ị attentiona ntị na njirimara nke mmekọrịta yana ọgwụ ndị ọzọ.

Site na nhazi ya n'otu oge na danazol, verapamil, amiodarone ma ọ bụ cyclosporine, ihe ize ndụ nke ịmalite myopathy na-abawanye.

N'otu oge, ojiji nke Zokora Forte na ọgwụ ndị bụ usoro nke bile acid na-enye nsonaazụ ọgwụgwọ dị mma.

Okwesiri iburu n’uche na enwere otutu ogwu ogwu ndi n’eme ka iwere n’orita nye Zokor Forte. Ndị a gụnyere:

erythromycin,
itraconazole,
ketoconazole,
telithromycin
nefazodone.

Ngwakọta nke ihe eji egbu egbu

Na mgbakwunye na akụrụngwa na-arụsi ọrụ ike nke simvastatin, mbadamba Zokor na ngwakọta ha nwere ihe ndị ọzọ. Themfọdụ n’ime ha bụ:

lactose na hypromellose,
MCC
ascorbic na citric acid,
ọka ọka
stereta magnesium,
iron oxide (edo edo na uhie).

Pharmacodynamics na pharmacokinetics

Zokor na-egbochi mmechi HMG-CoA na metabolites ya ma na-egbochi njikọ mevalonate, nke na-ebelata mmepụta nke stearols na ụmụ irighiri cholesterol. Na mgbakwunye na akụrụngwa inhibitory, ọgwụ ahụ na - eme ka ndị na - anabata ndị na - anabata mkpụrụ ndụ akwara na - aza lipids dị ala dị ala. Ndị na-anabata ihe ndị a na - ejide irighiri irighiri nke LDL ma kwalite catabolism ha.

Usoro ihe omume nke statins

Mbelata HMG-CoA reductase na simvastatin na - eduga ụdị ọgwụ a na - ewere statin:

obere mkpokọlọtọ cholesterol,
na-ebelata irighiri ihe nke LDL,
na-agbadata irighiri ihe na triglycerides na obere cholesterol nke VLDL,
na-ebelata apolipoprotein B,
njupụta nke mkpụrụedemede dị elu (HDL) na-abawanye ruo - 14.0%,
mmụba na apoA index.

Mmetụta ọgwụ mbụ sitere na iji Zokor nwere ike inwe mmetụta mgbe izu abụọ gachara, yana kachasị - ka ụbọchị kalenda 30-45 gasịrị.

Pharmacokinetics Zokor dị n’ahụ mmadụ gosipụtara dịka ndị a:

ịdị elu nke simvastatin dị n'ọbara bụ otu awa na ọkara ka elekere abụọ mgbe nchịkwa ọnụ gasịrị. Nkpughepu dabere n’usoro ogwu nke dọkịta nyere.
a na-etinye obi gị dum n'ime ahụ ihe karịrị 85% nke usoro eji were ọnụ,
bioavailability nke ọgwụ - 20%,
ọgwụ ahụ na-abanye ihe mgbochi placental n'oge afọ ime,
95% ọgwụ ahụ jikọrọ protein na ogige ha.
enweghi aru nke simvastatin n’ime ahu, nke n’eme ka i were ogwu gwọ ihe eji abanye ogologo oge,
ọkara ndụ simvastatin sitere na awa 18 ruo 20,
70% na-ewepụ Zokor site na enyemaka nke bile acids na eriri afọ ya na feces,
10% nke akụrụngwa bụ isi dị na mmamịrị.

Ihe ngosi maka ojiji na contraindications

Denye onye na-eweda mmanụ nke Zokor maka ọgwụgwọ ụfọdụ ọrịa. Themfọdụ n’ime ha bụ:

isi heterozygous familial hypercholesterolemia,
homozygous ọrịa hyperlipidemia,
gwakọtara hypercholesterolemia,
dysbetalipoproteinemia na nri,
hypertriglyceridemia yana nri.
iji mee ka usoro ntụpọ nke atherosclerosis kwụsịlata.

Ọzọkwa, a na-enye ọgwụ ahụ ka ọ bụrụ ihe mgbochi na-esote oge ọgbụgba yana mgbe ọrịa strok gasịrị.

Ojiji nke statin maka ebumnuche bu ihe dị irè, ya bụ maka:

mgbochi nke infarction myocardial na ọrịa ụbụrụ,
belata ọrịa nke ọrịa na-akpata nnukwu ọbara ọgbụgba na ọnwụ na ọnụnọ nke ọnya a,
igbochi ugboro ugboro na ike nke ischemic transient ọgụ,
nkwusioru nke nmeghari atherosclerosis,
na-ebelata irighiri cholesterol nke LDL, na ịba ụba nke HDL na plasma ọbara.

Ihe mgbochi na statins

Edeghị Statins maka ọnọdụ na nsogbu ndị dị na ahụ onye ọrịa:

anabataghị akụrụngwa na lactose,
mmụba nke transaminases sel sel,
ọrịa imeju na nnukwu ogbo nke mmepe nke pathology,
ụdị ịba ọcha n'anya na ụdị nje,
akwara myopathy
akụkọ banyere ọrịa akwara na onye ọrịa
n'oge ime na lact,
ụmụaka na-erubeghị afọ 10.

Womenmụ nwanyị nọ n’ọgbọ ọmụmụ ka ka edobere ya naanị ihe mgbochi dị mma. Ọ bụrụ na a chọpụta nwanyị n’ime ime n’oge ọgwụgwọ, a ga-akwụsị ọgwụ ahụ ozugbo, n’ihi na simvastatin na-agafe ihe mgbochi placental ma nwee ike imetụta nguzobe ọkpụkpụ na akwara n’afọ, na-ebute mmepe intrauterine nke mkpụrụ ndụ akwara.

Undermụaka na-erubeghị afọ 10 na-enyeghị ọgwụ maka nnukwu ihe egwu nke ịmalite ọrịa myopathy na rhabdomyolysis nke mkpụrụ ndụ akwara.

Ntụziaka maka ojiji

A na-ewere Zokor otu ugboro n'ụbọchị. A na-eme nke a tupu ị lakpuo ụra. Agaghị ata ata mbadamba ụta ahụ, mana a gha-elo ya kpamkpam, wee jiri mmiri dị ọcha sachaa ya.

Tupu ịmalite ọgwụgwọ statin, onye ọrịa ahụ ga-enwerịrị nri kọlestrọl maka ọnwa 1-2. Nri ahụ kwesịrị iso usoro ọgwụgwọ Zokor.

Dọkịta ahụ na-ahọrọ usoro onunu ogwu niile n'otu n'otu maka onye ọrịa ọ bụla, dabere na njiri anụ ahụ, ọdịdị nke ọrịa na ogo nke oganihu ya, ọ nwere ike ịbụ site na 5 mg ruo 80 mg kwa ụbọchị. You nwere ike ịbawanye ọgwụ kwa ụbọchị ka ọgwụ a ghara tupu i were izu 4 iji were mbadamba ọgwụ. Achọghị ihe karịrị 80.0 mg nke ihe mejupụtara simvastatin kwa ụbọchị maka ndị ọrịa.

Bido ụzọ ọgwụ a site na 5 mg, 10 ma ọ bụ 20 mg. Oge nnọkọ nke mbụ na-adabere na ọrịa na ihe ngosipụta nke profaịlụ nke egbugbere ọnụ:

Ekwesịrị iji usoro hypercholesterolemia malite site na usoro nke 10 mg. N'ime usoro ọgwụgwọ, enwere ike ịbawanye usoro a (nke nta nke nta), ruo na oke akwadoro kwa ụbọchị - na 80 milligrams.
Maka igbochi ọrịa obi na hyperlipidemia ma ọ bụ dyslipidemia, enwere ike ị doseụ ọgwụ 40 mg.
Maka ọgwụgwọ nke hyzycholesterolemia nke homozygous, dọkịta depụtara ọgwụ 40 mg. Ọ bụrụ na enweghị ọgwụ ọ bụla, yabụ mgbe ọnwa gachara ọgwụ, etinyere ọgwụ ọnụọgụ 80 mg. A na-ekewa dose ahụ n'ụtụtụ nke 40 mg na ọgwụ mgbede n'otu usoro.
Agaghị eme ka ndị agadi agadi mezie etu usoro mbadamba ihe dị. Enweghikwa mkpa maka idozigharị dose maka obere nsogbu gbasara akụrụ.
Frommụaka sitere na afọ iri site na ọrịa hypercholesterolemia nke ụdị homozygous, dọkịta na-edepụta ọgwụ 10 mg kwa ụbọchị. Maka ụmụaka na-erubeghị afọ 18, a pụrụ ịmụba ọgwụ a na-enye ọgwụgwọ ruo milligram 40 kwa ụbọchị. A naghị enye usoro onunu ogwu nke 80 mg na nwata.

Effects nwere ike inwe mmetụta ọjọọ yana ị andụbiga mmanya ókè

A na-anabatakarị akụkụ mbụ nke anụ ahụ nke ọma, ọtụtụ mgbe mmetụta ọ bụla nwere ike ịpụta n'oge ọgwụgwọ na ọgwụ nwere ọgwụ ọnụọgụ 40 mg, ma ọ bụ mgbe ị na-a medicineụ ọgwụ nwere oke ọnụọgụ kwa ụbọchị - 80 mg.

Ihe karịrị pasent 10 nke ndị ọrịa na-enweta ụdị ahụ a na-a reactionsụ na ị takingụ ọgwụ:

mmepe nke anaemia,
ntutu isi
akpụkpọ anụ dermatomyositis,
dizzness, migraine,
dyspepsia
jaundice nke nri etiology,
myalgia na myopathy,
ogwe
nnukwu pancreatitis
apa ukwu,
neuropathy nke ngalaba ngalaba,
rhabdomyolysis,
urticaria na itching.

Mgbaàmà ndị a na-enwekarị:

mkpụkpu ume
Akụkụ akụkụ ahụ nke akụkụ,
arthralgia,
ike ọgwụgwụ
thrombocytopenia
mmụba na ESR,
enweghi ike na nwoke.

Naanị ihe mgbaàmà nwere ike ịbụ ụdị mmeghachi omume nke anụ ahụ,

mmụba nke enzyme phosphokinase,
mmụba na ndekọta nke phosphokinase,
mmụba siri ike na transaminase index na mkpụrụ ndụ imeju.

Ọ bụrụ na ị anụbiga mmanya ókè, a na-eji ọgwụgwọ na usoro ọgwụgwọ gastric eme ihe. Usoro ịba ọcha n'anya adịghị arụ ọrụ.

Ekwesịrị ịgwa ndị ọrịa niile banyere ekwe omume nke ịmalite ọrịa muscle tupu ịmalite. Should kwesịrị ị paya ntị na atụmatụ ndị a:

na oke mgbu ọ bụla na akwara ike ma ọ bụ ọkpụkpụ, onye ọrịa kwesịrị ịhụ dọkịta. Ọtụtụ mgbe, iwere Zokor na-akpata ike ọgwụgwụ,
n'oge ọgwụgwọ na mbadamba ụrọ na usoro onunu ogwu nke 20 mg ma ọ bụ 40 mg nke akụrụngwa na-arụ ọrụ, ileba anya na ọrụ nke creatine phosphokinase n'ime ọbara, yana ọrụ akụrụ.

Mmụba na ndekọta nke phosphokinase creatine bụ ihe ịrịba ama banyere mmalite nke myopathy na usoro akwara. A ga-akwụsị ịgwọ ọrịa ahụ ma ọ bụ kwe ka ọgwụ ahụ gbanwee ka ọ dịkarịa ala.

Nyocha nke ndị dọkịta na ndị ọrịa

Nyocha banyere Zokora na-akacha mma. Ma ndị ọrịa ma ndị dọkịta hụrụ uru ọgwụ dị dị elu:

Onye na-ahụ maka hypolipPs Zokor dị mma maka ọkwa ọ bụla nke nsogbu akwara ume ọkụ na ahụ. Na mgbakwunye, a na-eji ya dị ka prophylaxis maka ọrịa dị egwu nke sistemu hematopoietic na obi, yana n'ọkwa mgbake site n'ọrịa ọwụwa na nkụchi obi, yana na oge mgbake postoperative.

Ntụziaka pụrụ iche

Dị ka ọgwụ ọjọọ ndị ọzọ - ndị na - egbochi GM-CoA reductase, Zokor nwere ike ịkpasu mmepe myopathies. Mgbe ụfọdụ, ọ na-egosipụta onwe ya n’ụdị rhabdomyolysis, nke ụfọdụ na-esonyere nnukwu akwara ọdịda.

Zere imekọ ihe ọnụ nke Zokor na ọgwụ, nke, mgbe ewere ya n'otu oge, nwere ike ịkpasu ngosipụta myopathy.

A ga-adọ ndị ọrịa niile ọgwụ Zocor aka na ntị ka ha nwee ike igosipụta ya. myopathiesna mkpa, mgbe mmepe nke mgbaàmà mbụ nke ọrịa a, gakwuru dọkịta ozugbo. Na mbido mbụ nke mmepe myopathy, ọgwụgwọ kwesịrị ịkwụsị.

N'ime ụfọdụ ndị ọrịa natara Zokor, ọnụọgụ nke enzyme imeju ka a chọpụtara. Mgbe nkwusioru ọgwụgwọ gasịrị, ndị gosipụtara jiri nwayọọ nwayọọ laghachi ọkwa mbụ.

Tupu ịmalite usoro ọgwụgwọ, ọ dị mkpa iji duzie ọmụmụ banyere ọrụ imeju. Ekwesịrị imeghari ọmụmụ ihe a tupu ịbawanye ọgwụ nke simvastatin na nke kachasị elu kwa ụbọchị.

Na ọdịda akụrụngwa akwara na-adịghị ala ala, ọ dị mkpa ka onye ọrịa belata dose nke ọgwụ ahụ. Na ọdịda akụrụngwa siri ike, enwere ike ịgụta ọgwụ nke ihe karịrị 10 mg naanị mgbe nnabata nke dọkịta na-abịa.

Usoro na ọnọdụ nchekwa

Ndụ nchekwa nke ọgwụ a site na mgbe ọ mepụtara bụ afọ abụọ.

Ekwesịrị idobe mbadamba nkume ndị ahụ na nkwakọ ngwaahịa mbụ na okpomọkụ agaghị akarị + 25-30⁰, n'ebe gbara ọchịchịrị ma kpọọ nkụ ụmụaka.

Ọgwụ Zokor Forte bụ naanị ndenye ọgwụ.

Ọnụ ahịa ya n'ụlọ ọgwụ ndị Russia ruru 450-500 rubles (maka ngwugwu nwere mkpụrụedemede 14) yana 700-750 rubles (maka mbadamba 28)

Pharlọ ọgwụ na Ukraine kwe nkwa izu ọgwụ a na ọnụahịa nke hryvnia 150 ruo 500, dabere na ọnụ ọgụgụ mbadamba dị na mkpọ.

Ndị na-ahụ maka ọgwụ n'oge a na-enye ọtụtụ analogues nke Zokora Forte, nke nwere otu ihe na-arụ ọrụ ma nwee mmetụta hypolipedic.

Mgbe ị na-ahọrọ otu, ọ ga-adị mma ka ị gaa hụ dọkịta.

Analogs ndị kasị ewu ewu nke mbadamba Zocor Forte bụ:

Ọgwụ Zokor Forte kwesịrị inweta ọtụtụ nyocha dị mma maka adreesị ya n'ihi ịdị mfe nke iji ya na mmetụta ọgwụgwọ dị elu.

Imirikiti ndị ọrịa jiri ya mee ihe maka ọgwụ na ahụike, kwuru na cholesterol belatara nke ọma yana mmetụta dị mma na steeti sistem.

Na njedebe nke edemede a, ị nwere ike ịchọta nyocha zuru ezu banyere ọgwụ a. Ọ bụrụ n’inwe ahụmịhe nke gị n'iji mbadamba Zokor Forte, jide n'aka na ị ga-eso ndị ọbịa ndị ọzọ na saịtị ahụ kerịta echiche gị.

Kedu ihe ị ga-atụle tupu ewere mbadamba Zocor Forte?

Ọgwụ Zokor Forte, nke a gosipụtara n’ụdị mbadamba nkume, bu n’obi maka ọgwụgwọ na mgbochi nke ọrịa obi na akwara, yana atherosclerosis.
Ihe kacha anabata ị ga-anabata kwa ụbọchị bụ 80 mg.
Amachibidoro ị medicationụ ọgwụ n'oge afọ ime na mgbe a na-enye ya ara, ọrịa imeju siri ike, yana n'ihe banyere ịnabata mmadụ n'otu n'otu.
Mgbe ị na-agwọ ọrịa, a ga-ewepụrịrị ihe ọholicụ alcoụ mmanya na-egbu egbu na nri.
Ekwesighi ịgabiga usoro ọgwụgwọ nke dọkịta depụtara.

Ntụziaka na iji Zokor: analogues, reviews, mejupụtara, ọnụahịa

Lekarstva.Guru> Z> Ntụziaka na ngwa Zokor: analogues, reviews, mejupụtara, ọnụahịa

Zokor forte bụ ọgwụ na - egbochi mmepe nke ọrịa obi. Ọ bụghị naanị na-agbada ọkwa cholesterol dị njọ na ọbara onye ọrịa, kamakwa ọ na-agbago ọkwa nke mkpokọta cholesterol ka ọ dị mma. Site na njirimara kpokọtara ya, Zokor belata ọnụ ọgụgụ ndị ọrịa na 30%! N'ime ndị ọrịa mamịrị, ọ bụrụ na ihe dịka 55% belata nsogbu ihe ọgbụgba.

Zokor - Kedu ihe ọ bụ?
Mpempe mwepụta
Ihe ngosi maka ojiji
Ihe ngbanwe
Ntụziaka maka ojiji, usoro onunu ogwu
Nsonaazụ

Zokor - Kedu ihe ọ bụ?

Zokor bụ ọgwụ ndị e ji mmanye mmanu nweta. A na - enweta ya site na gbaa ụka site na Aspergillus terreus. Ọrụ umi nke ọgwụ Zokor forte - simvastatin.

Nke a bụ lactone na-adịghị arụ ọrụ, na-abanye na usoro nke hydrolysis, ọ na-etolite usoro hydroxy-acid. Ya, n'aka nke ya, bụ metabolite nke na-egbochi HMG-CoA.

HMG-CoA bụ ihe nwere ike ịgbado ọkụ, ma ọ bụ enzyme nke nwere ikike imebe ihe bụ isi na ịmachi ọsọ nke ọkwa cholesterol biosynthesis n'ahụ mmadụ.

HMG-CoA, na-atụgharị mevalonate, bụ ọkwa bụ isi nke cholesterol biosynthesis. Ya mere, ojiji nke Zokor forte anaghị eme ka usoro nchịkọta nke sterol na-egbu egbu na ahụ.

Emere nke a site na omumu emere emere na UK maka afo 5 na onwa ise.

Na mgbakwunye na ihe niile dị n'elu, enwere ike ịgbanwe HMG-CoA na Co-A, enzyme na-etinye aka na ọtụtụ usoro biosynthesis.

Okwesiri iburu n'uche na otutu ihe omimi na - enyocha - ogwu Zokor dokwara anya maka ndị ọrịa niile. Ikike zuru oke anaghị adabere na afọ, okike, ọkwa cholesterol ma ọ bụ enweghị / ọnụnọ nke usoro ọgwụgwọ.

Ọ bụrụ n’inwe obi abụọ banyere ọgwụgwọ ị nwere, nyocha ịntanetị nwere ike inyere gị aka ịtụle akụkụ niile dị mma na nke na-adịghị mma nke ọgwụgwọ ahụ.

Ntụziaka maka ojiji, usoro onunu ogwu

Dịka ntuziaka ahụ si dị, tupu ịmalite iji ọgwụ Zokor forte, a ga-enyerịrị onye ọrịa ahụ ọgwụ nri hypocholesterol. Ọ dị mkpa ịgbaso nri dị otú ahụ n'oge usoro ọgwụgwọ niile.

Usoro akwadoro nke egosipụtara na ntuziaka ndị ahụ sitere na 5 mg ruo 8 mg. Ọ dị mkpa iji ọgwụ ahụ na mgbede, otu ugboro n'ụbọchị. N'ime oge ịhọrọ oke ọgwụ kachasị mma, a ga-ahụrịrị oge oge a: ịkwesịrị ịgbanwe ụbọchị kwa ụbọchị nke Zocor agaghị karịa oge 1 n'ime izu anọ. Onu ego kwere ka Zokor forte kwa ubochi bu 80 mg.

Ekwesịrị ịsa anya maka nhazigharị dose ka ndị ọrịa nwere ọrịa akwara ozi ma ọ bụ ihe egwu nke ibute ọrịa akwara na akwara. Ogo kachasị anabata kwa ụbọchị, maka ndị ọrịa dị otú a, belatara nke ukwuu - 40 mg. Were ọgwụ ahụ 1 oge kwa ụbọchị, na mgbede.

Soro ntuziaka ogwu gha agwakọta tinyere nri pụrụ iche na usoro mmega ahụ maka ndị ọrịa:

Ọrịa ọrịa ischemic na-arịa ya ma ọ bụ n'ihe ize ndụ nke ịmalite ọrịa obi nke ischemic,
Ọrịa shuga mellitus
Akụkọ banyere ọrịa ụbụrụ,
na-arịa ọrịa ịrịa akụkụ.

A na-enye ndị ọrịa nwere hypercholesterolemia ndị agabeghị na listi ndị a dị n'elu. Basickpụrụ dị mkpa dị na nke a bụ 20 mg. Were ọgwụ otu ugboro n'ụbọchị, na mgbede.

Maka ndị ọgwụgwọ ha gụnyere mbelata dị ukwuu na ọkwa LDL, a na-amụba usoro mbụ ruo 40 mg. Ọ bụrụ na onye ọrịa ahụ nwere hypercholesterolemia dị nro, mgbe ahụ ego ị ofụ ọgwụ ahụ bụ 10 mg.

Nhọrọ nke dose ahụ ga-ebu dị ka ntuziaka ndị a si dị, na oge egosipụtara nke mgbanwe dose ahụ egosipụtara.

Homositic familial hypercholesterolemia na-enye ụdị nnabata abụọ. Nke mbu: a na-a theụ ọgwụ ahu otu oge kwa ụbọchị, na mgbede, na 40 mg. Nke abụọ: 80 mg ọgwụ ahụ na-ekewa ụzọ atọ:

A na-eji ikpe a mee ihe ma ọ bụrụ na ọgwụgwọ ọzọ, gụnyere nnukwu Mbelata cholesterol, anaghị emetụta na nke a. Ma ọ bụ Zokor ka e jiri mee ihe gbasara ọgwụgwọ.

Ọ bụrụ na onye ọrịa ahụ na - etinye fibrates, a na-ahazi dose kwesịrị ekwesị n'otu n'otu site na ndị ọrịa, dabere na-edere fibrates.

Ebe ọ bụ na ọdịda akụrụ bụ nnukwu contraindication maka ọgwụgwọ na Zokor forte, ha na-agbakarị dochie ya na analogues.

Mana ọ bụrụ na anabataghị nhọrọ a, ọ dị mkpa ịnye nsogbu niile enwere ike ma kpebie na n'ihe banyere onye ọrịa, ọ dị mma iji Zokor forte.

Agbanyeghị, ọ bụrụ na onye ọrịa ahụ nwere nsogbu gbasara akụrụ dị nro, a naghị edozigharị usoro nke ọgwụ ahụ. Ebe ọ bụ na albeit na obere ego, mana akụrụ na-ewepụ ya mgbe niile.

Nsonaazụ

Dika ihe omumu, ihe omuma nke nsogbu ozo mgbe etinyechara Zokor forte bu naanị 2%. Maka nke a, ịgwọ ọrịa na mbadamba Zokor dị mma maka analogues. Na mgbakwunye, iwu ịnye ọnụahịa nke ngwaahịa a anaghị ebu ọnụ. Ọnụ ego ọgwụ na Ukraine sitere na 15 ruo 30 UAH. Ọnụ ego na Russia bụ site na 400 ruo 700 rubles.

Tupu ị activeụ ọgwụ ike n'ọrụ ahụike, 1% bụ ikpe ụdị mmetụta ndị adị ka:

Mmetụta ndị ọzọna-ejikọta ya na iji ọgwụ ahụ bilitere na 0.5-0.9% nke ikpe:

Enwere ihe akaebe banyere ikpe ikpe gbasara myopathy.

Ọdịdị mgbaàmà ndị a nwekwara ike:

Dizziness
Ahụ erughị ala
Ọrịa ịba ọcha n'anya
Ọrịa afọ ọsịsa
Ọrịa mgbu
Vomiting
Jaundice
Ọkpụkpụ akwara ozi,
Rhabdomyolysis,
Myalgia
Dermatomyositis
Itching
Akpụkpọ anụ ahụ
Akwara ahu
Isi ike
Ọbara

Ihe omumu ihe omumu, na otutu ihe omume emeputala ihe omuma nke imebiga ihe oke ókè n’ime ndi oria. Ogo ogwu a kapịrị ọnụ dị 3.6 g. N'ọnọdụ ịdoụbiga ya ókè, a na-enye onye ọrịa ahụ nlekọta na usoro ọgwụgwọ Symptomatic.

Tupu usoro ọgwụgwọ dị mkpa nyocha nke oma banyere akụrụ. Ekwesiri imeghari omumu ihe a tupu uto nke ogwu a.

N'ime ndị ọrịa na-a theụ ọgwụ ahụ, a chọpụtara mgbanwe n'ọkwa enzyme hepatic. Agbanyeghị, mgbe akwụsịchara usoro ahụ, ndị gosipụtara jiri nwayọọ nwayọọ lọghachi na nkịtị.

Ọ bụrụ na onye ọrịa nwere ajọ akụrụngwa gbasara akwara, mmụba n'ụkpụrụ iwu (10 mg) bụ naanị mgbe ọ gbasachara ajụjụ na ikike onye ọkachamara nyere ya.

Nkọwa nke ọgwụ Zocor

Jọ tụrụ m ịnabata ọgwụgwọ, mana dọkịta ahụ kwusiri ike, kwuru na n'ọnọdụ m, ọgwụgwọ ọzọ agaghị arụ ọrụ. Ọ dabara nke ọma, ha mere ka m kwenye na m na-aga ugbu a.

Milena, Kharkov

Enwere m nnukwu nsogbu gbasara akụrụ na cholesterol dị elu. Agwara m ikwenye na ọgwụgwọ Zokor. Ogologo oge ahọpụtara ọgwụ a na-anara nke ọma, mana ihe ndị a dị ntakịrị, ihe bụ na ọrịa ahụ n'azụ. Obi dị m ụtọ.

Alexander, Minsk

N’eziokwu, adighi m oke nma na ọgwụ, yabụ dọkịta kwuru - nke ahụ pụtara na anyị ga-ekwenye. Isi ihe bụ ịchọta onye ọkachamara kwesịrị ekwesị ị kwenyere na ya, mgbe ahụ ọgwụgwọ ọ bụla ga-aga nke ọma. N'ozuzu, ahụmịhe m bara uru.

Svetlana Oryol

Zokor: ntuziaka maka ojiji, ọnụahịa, nyocha na analogues

A na-eji ọgwụ Zpopo hypolipPs belata ndepụta cholesterol ọbara na hypercholesterolemia. Zokor bụ onye na - egbochi HMG-CoA reductase ma bụrụ akụkụ nke ìgwè ọgwụ ọgwụ nke statins. N'isiokwu a, anyị ga-atụle ntuziaka maka ojiji nke ọgwụ Zokor, ihe ndị na-egosi na contraindications, analogues na nyocha.

Phardị ọgwụ ọgwụ

Onye nrụpụta ahụ na-emepụta ọgwụ ahụ n'ụdị mbadamba. Mbadamba ụrọ nwere ọgwụ nke ọgwụ mejupụtara 10 mg nwere obere pink pink, ụdị oval nke dị n'otu akụkụ, na ihe osise dị n'akụkụ nke ọzọ.

Mbadamba Zokor nke nwere 20 mg simvastatin nwere agba aja aja, agba dị mma n’otu aka, a na-akanye ihe n’okpuru nke ọzọ.

Mbadamba nwere usoro nke simvastatin 40 mg (Zokor Forte) nwere agba pink, ụdị oval larịị n'otu akụkụ, na ihe osise dị n'akụkụ nke ọzọ.

Wokwara na mbadamba nkume na blisters nke 14 iberibe. Nkwakọba kaadiboodu nke ọ bụla nwere ike inwe blister 1 ma ọ bụ abụọ.

Ntụziaka a gosipụtara site na ntuziaka maka ojiji. A ga-atụle Analogs nke Zokor n'okpuru.

Ihe ngosi maka ojiji

A na-atụ aro ọgwụ ahụ ka ndị ọrịa jiri otu ahụ dị ize ndụ maka mmepe nke ischemia cardiac. Ọzọkwa n'ihe ize ndụ gụnyere ndị nwere ọrịa dịka:

Ọrịa gbasara mgbasa.
Ọrịa shuga mellitus.
Ọrịa Cerebrovascular.

Enwere ike iji ọgwụ ahụ gwọọ ndị ọrịa na-arịa ọrịa obi ischemic, hypercholesterolemia. N'okwu a, ọ na - enyere aka igbochi atherosclerotic pathologies nke obi na arịa ọbara.

Ndepụta nke ngosi maka iji ọgwụ "Zokor" bụ ihe ịtụnanya.

Enwere ike ịkwado ya maka iji ya n'ọnọdụ ndị a:

Omodị familial nke Homozygous (hypercholesterolemia) (ya na usoro nri, ụzọ ndị ọzọ).
Cholesterol dị ala nke ịdị elu dị ukwuu na-emetụta hypercholesterolemia bụ isi nke usoro ọgwụgwọ nri.
Hypertriglyceridemia.
Ogo nke apolipoprotein B, cholesterol zuru oke (yana yana nri nri).

Mmetụta ọjọọ

Dabere na ntuziaka maka ojiji na nyocha na "Zokor", akara ndị a na-adịghị mma nwere ike ịmalite na onye ọrịa n'oge ọgwụgwọ:

Arthralgia, mụbara ESR, ọrịa ogbu na nkwonkwo, eosinophilia, thrombocytopenia, dermatomyositis, vasculitis, angioedema.
Ọrụ mbelata, Rhabdomyolysis, myopathy.
Itching, alopecia, ihe otutu.
Imebi ụra, ebe nchekwa, paresthesia, neuropathy akụkụ, ihe ọdịdọ, ọgbụgba.
Ọbara, adịghị ike n'ozuzu, isi ọwụwa.
Ọrịa dispecation, bloating, mgbu nke afọ, erughi ala.

N'izugbe, ndị ọrịa na-anabata ọgwụ ahụ nke ọma.

Ojiji ogwu

Were ọgwụ "Zokor" n'ọnụ, na-ekwughị nri. Ihe dị ka ọgwụ a kwa ụbọchị 5-80 mg. 80 mg - usoro a pụrụ ịdabere na ya nke simvastatin, nke enwere ike iwere ụbọchị.

Ọkachamara ga-ahọrọ ọgwụ ahụ n’otu n’otu. Yabụ, maka ebumnuche nke ọgwụgwọ na mgbochi nke ọrịa obi na akwara na mgbakwunye na usoro nri, a na-egosi ị takeụ 40 mg nke Zokora kwa ụbọchị.

Iji gwọọ hypercholesterolemia, egosiputara iji 20 mg nke Zokor kwa ụbọchị.

Mmetụta imeju

Ọmụmụ nyocha ahụike na ndị okenye okenye na-anata simvastatin achọpụtala na-enwe mmụba na ọkwa nke enzymes imeju. Site na ịkwụsị ma ọ bụ nkwụsị nke ọgwụ, ọrụ nke transaminases na-ejikarị nwayọọ nwayọọ laghachi na uru mbụ ha. Ejikọghị nke a na jaundice ma ọ bụ mgbaàmà ndị ọzọ, mana ọ nwere ike igosipụta ọghọm na nsonaazụ nyocha imeju na / ma ọ bụ ị abuseụbiga mmanya ókè tupu ịmalite ọgwụgwọ. Achọpụtaghị mmeghachi omume hypers.

Otu ngwugwu nke mbadamba mkpụrụ osisi 28 nke Zokora nwere usoro ọgwụ nke 20 mg ga-efu ihe dịka 750 rubles, yana usoro ọgwụ nke 40 mg - 500 rubles. Ọ dabere na mpaghara na netwọ ọgwụ ahịa.

Analogs nke Zokora

Ọ bụrụ na ọ dị mkpa, enwere ike dochie Zokor na otu usoro ndị a yiri: Simvor, Zovatin, Simgal, Vabadin, Levomir, Aterostat, Simlo, Simvakard, Avestatin, Simvastatin, Akorta, Pravastatin, Simvastol, Ariescor, Simgal, Lovastatin, Lipitor, Liptonorm, Rosulip, Rosart, Tevastor, Atomax , Liprimar, Atoris, Rosucard, Vasilip, Roxer, Rosuvastatin, Tulip, Krestor.

Mmetụta nke ọgwụ ndị a yiri nke ahụ, mkpa iji ọgwụ a kapịrị ọnụ na nke ọ bụla kwesịrị ka dọkịta kpebie ya.

“Krestor” bụ otu n'ime ihe atụ nke “Zokor”. Ngwakọta ọrụ nke na-arụ ọrụ n'ime ihe mejupụtara ya bụ calcium rosuvastatin. Ihe ndi ozo bu: magnesium stearate, glycerol triacetate, E172, E171, hypromellose, calcium phosphate, lactose monohydrate, crospovidone, microcrystalline cellulose.

Onye rụpụtara "Crestor" dị n'ụdị mbadamba. Mbadamba ụrọ nke ọ bụla nwere ike ịnwe 5, 10, 20, 40 mg nke ihe arụ ọrụ. Dịka Zokor, Krestor bụ ọgwụ na-ebelata ọgwụ.

Kedu nke ka mma - "Zokor" ma ọ bụ "Crestor" bụ ihe siri ike idozi.

Isi ihe eji egosi ya maka ya bu:

Mgbochi nke mmepe nke ọrịa ọrịa obi.
Atherosclerosis
Agwakọta hypercholesterolemia (dị ka akụkụ nke ọgwụgwọ mgbagwoju anya yana ịba ụba, mmega ahụ, usoro nri).
Mgbochi, ọgwụgwọ nke hypercholesterolemia.

"Crestor" na contraindicated na ọnụnọ nke ndị dị otú ahụ physiological, pathological ọnọdụ dị ka:

Nkwanye akụkụ nke ọgwụ ọ bụla.
Afọ n’afọ iri na asatọ.
Myopathy
Usoro ọgwụgwọ na ọgwụ cyclosporin.
Oge ime, lactation.
Veredị siri ike nke ọrịa ịba ọcha n'anya, ọkachasị, jikọtara ya na mmụba n'ọnụ ọgụgụ transaminases n'ime ọbara.

Na-emegide nzụlite nke iji ọgwụ ahụ, mgbaàmà na-adịghị mma dịka:

Tubular proteinuria.
Asthenia.
Ọrịa afọ ọsịsa, afọ ntachi, pancreatitis, ọgbụgbọ.
Azịza Allergic.
Myopathy
Polyneuropathy, isi ọwụwa.

Were "Crestor" kwesịrị ịbụ ọnụ, dum, na-ezere ịta ata. A na-atụ aro ịmalite ọgwụ ọgwụ na ọgwụ mbụ nke 5 mg, mgbe izu atọ gasịrị dọkịta dọkịta na-ekpebi mkpa ịbawanye usoro onunu ogwu ka 20 ma ọ bụ 40 mg dabere na ahụike nke onye ọrịa.

Ndị ọrịa na-echekarị ọgwụ, Zokor ma ọ bụ Krestor, ka mma. Azịza nke ajụjụ a enweghị ike ịbụ ihe doro anya. Nke mbu, ihe eji eme ka aru di ike site na otutu ihe eji eme ihe. Nke abuo, aru nke mmadu obula di iche: ogwu nke nwere ike diri otu onye ọrịa apughi idabara onye ozo ozo. Ọ bụ ya mere ọkachamara kwesịrị iji họrọ ọgwụ kachasị dabara adaba.

Simvastatin

"Simvastatin" bụ ihe analog nke "Zokor" n'ihe gbasara mpaghara mebere, ọ dabere na simvastatin. A na - eji ihe inyeaka: butylhydroxyanisole, macrogol, talc, hypromellose, ascorbic acid, stachi ọka, lactose, povidone, citric acid, titanium dioxide, calcium stearate.

Onye mepụtara "Simvastatin" dị n'ụdị mbadamba, jikota ya na blisters ma ọ bụ ite nke polymer plastik ma nwee usoro onunu ogwu 10, 20, 40, 80 mg.

N'ime ihe ngosi nke iji Simvastatin bu onodu ndi a:

Mgbochi mgbasa nke atherosclerosis.
Mgbochi nke mkpịsị ugodi mgbu afọ, ọrịa strok.
Mgbochi nke infarction myocardial.
Hydị ejikọtara ọnụ hypercholesterolemia, hypertriglyceridemia (ma ọ bụrụ na mmega ahụ zuru oke na usoro ọgwụgwọ nri anaghị arụ ọrụ).
Hypercholesterolemia nke mbu (ma ọ bụrụ na enweghi arụmọrụ site na ụzọ ndị na-abụghị ọgwụ na ọgwụgwọ nri) na ndị ọrịa nọ n'ihe ize ndụ nke ịmalite ọrịa atherosclerosis.

"Simvastatin" bụ contraindicated kpam kpam iji ma ọ bụrụ na onye ọrịa ahụ nwere ụdị ọrịa a, ọnọdụ ahụ ike:

Afọ n’afọ iri na asatọ.
Ọrịa imeju na-arịa ya.
Onwe onye nwere ike ị nweta ihe ndị ọgwụ dị na ya.
STbawanye na AST, ALT.
Myopathy, akwara ọkpụkpụ akwara ndị ọzọ.

N'ime ọgwụ mgbochi (ọnọdụ chọrọ iji ọgwụ ahụ akpachara anya):

Ihe ịwa ahụ, mmerụ ahụ.
Akwụkwụ na-adọ
Ọrịa metabolism.
Ihe akara akara nke usoro endocrine.
Ihe nleghara anya bu mmiri sitere na mmiri.
Nnukwu ọgbụgba.
Mmanya
Oge ndozigharị mgbe agbatịchara akụkụ ahụ, ọgwụgwọ immunosuppressive.

Ojiji nke "Simvastatin" nwere ike imetụta ọnọdụ onye ọrịa n'ụzọ na-adịghị mma, na-akpata ọrịa ndị dị ka:

Ọrịa ọgbụgba, ọrịa palpitations, nnukwu ụdị akụrụ nke ọdịda, nke rhabdomyolysis kpasuru iwe, nwere ikike belata.
Alopecia, pruritus, dermatomyositis.
Myalgia, rhabdomyolysis, adịghị ike siri ike, myopathy, cramps muscle.
Mkpo ume, mkpịsị ogbu na nkwonkwo nke anụ ahụ, ịba ụba ESR, ahụ ọkụ, urticaria, photoensitivity, lupus-like syndrome, eosinophilia, polymyalgia rheumatica, thrombocytopenia, angioedema.
Ọkpụkpụ akwara ozi.
Incusnia, akwara mgbu, uto uto, ọgbụgba, paresthesia, ọrịa asthenic, migraine, ọhụhụ ụzọ.
Nausea, afọ ọsịsa, ọgbụgbọ, ịba ụba AST, ALT, CPK, afọ ntachi, mgbu epigastric, flatulence, pancreatitis.

Ojiji nke "Simvastatin" kwesiri ịmalite site na iji obere ntakịrị, jiri nwayọ na-abawanye ha kwa ọnwa. A na-atụ aro ka ị theụ ọgwụ ahụ otu ugboro n'ụbọchị, n'oge ụra, na-ewere mbadamba 1. Dọkịta kpebisiri ike iji usoro ọgwụgwọ ahụ dabere n'ọnọdụ onye ọrịa. Dịka iwu, a na-ahụta ịdị irè nke ọgwụ ahụ mgbe ị na-eji 20 mg nke ọgwụ kwa ụbọchị.

Ọnụ ego nke otu ngwugwu Simvastatin bụ 400 rubles.

Simgal bu ihe nlere nke Zokor n’uzo nke ihe eji enyere aka. O nwere simvastatin. Ihe ndi ozo bu: lactose monohydrate, microcellulose, magnesium stearate, citric acid monohydrate, siteri pregelatinized, butyl hydroxyanisole, ascorbic acid.

Onye mepụtara "Simgal" dị n'ụdị mbadamba, mbadamba nwere ike ịnwe ọgwụ onunu nke simvastatin 10, 20, 40 mg.

Isi ihe eji egosi Simgal:

Mgbochi Ọrịa CCC na ndị ọrịa na-arịa ọrịa shuga mellitus, atherosclerosis.
Ọgwụ nke hypercholesterolemia (nke bụ isi, hecheitary homozygous).
Ọgwụgwọ nke dyslipidemia gwara ọgwa.

A na-eme ka Simgal nọrọ n'ọnọdụ ndị a:

Usoro ọgwụgwọ nwere ọgwụ ọgwụ nwere ike igbochi cytochrome CYP3A4 (Nefazodon, Telithromycin, Itraconazole, Nelfinar, Clarithromycin, Erythromycin).
Oge ịgba akwụkwọ, ịtụrụ ime.
Ihe dị elu nke transaminases.
Nkpatu nke ọrịa ịba ọcha n'anya.
Susba ụba nwere ọgwụ ndị dị na ọgwụ ahụ.

Na nloghachi ojiji nke "Simgal", ihe mgbaàmà na-esote nwere ike ịmalite:

Mmụba alkaline phosphatase, transaminases.
Adịghị ike, mkpụmkpụ ume, eosinophilia, photoensitivity, thrombocytopenia, polymyalgia nke ụdị rheumatic, ogbu na nkwonkwo, vasculitis, angioedema.
Asthenia, myositis, spasms muscle, myopathy.
Alopecia, itching, ihe ngbu, ahuhu, oria.
Ọrịa mgbu, afọ mgbu, vomiting, stool iwe.
Pnepheral polyneuropathy, nkwarụ, anya mmiri, paresthesia, isi ọwụwa, anaemia.
Mmebi nwoke na nwanyị, ịda mba, ebe nchekwa, ụra.

A na-atụ aro ị Simụ Simgal otu ugboro kwa ụbọchị maka 10-20 mg. N'ọnọdụ ụfọdụ, na nkwekọrịta na ọkachamara, a na-ekwe ka mmụba nke ọgwụ kwa ụbọchị ruo 80 mg. Ọ bụrụ na achọrọ, mbadamba nkume nwere ike kewaa ọtụtụ akụkụ. Dọkịta gị ga-ekpebi ogo ị ofụ ọgwụ ọ bụla.

Nyochata ndị ọrịa gbasara Zokor

Ejiri ọgwụ a na ọgwụ analogues mara ndị ọrịa dịka ụzọ dị mma iji gbochie ọrịa CVS na ọgwụgwọ hypercholesterolemia. A na-ekwupụta oge dị mma iji ọgwụ ọjọọ eme ihe, ọtụtụ mgbe ndị dọkịta na-atụ aro otu ọgwụ kwa ụbọchị nke ọgwụ ahụ, nke na-eme ka onye ọrịa ahụ nwee ohere dị ukwuu.

Anyị nyochara ntuziaka maka iji Zokor, nyocha, yana analogues na ya.

Usoro onunu ogwu na nhazi

Tupu na mgbe usoro ọgwụgwọ ahụ, a ga-ahụrịrị usoro hypocholesterol. N'ime, na usoro izizi nke 10 mg otu ugboro, na mgbede, na hypercholesterolemia dị nro ma ọ bụ agafeghị oke, ọgwụ mbụ bụ 5 mg, ọ bụrụ na ọ dị mkpa, a na-eji nwayọọ nwayọọ mụbaa dose ahụ na oge nke izu anọ. Site na hyzycholesterolemia homogengous, ọgwụ kwa ụbọchị bụ 40 mg otu ugboro, na mgbede ma ọ bụ 80 mg / ụbọchị (kewara n'ime usoro 3 - 20 mg n'ụtụtụ, 20 mg n'ehihie, 40 mg na mgbede). Site na ọrịa obi, usoro izizi bụ 20 mg, otu oge, na mgbede, ọ bụrụ na ọ dị mkpa, ọ na-eji nwayọ nwayọ na oge nke izu anọ na 80 mg.

Nchedo nchekwa

Ndụ shelf nke ọgwụ Zokor®

10 mg mbadamba ihe mkpuchi - 3 afọ.

mbadamba ihe mkpuchi-20 mg - 3 afọ.

Mbadamba ụrọ dị arọ 10 mg - afọ 3.

Mbadamba mbadamba 20 mg - 3 afọ.

Mbadamba ụrọ 40 mg - 2 afọ.

Mbadamba mbadamba 80 mg - 2 afọ.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Ntụziaka maka iji Zokora: usoro na usoro onunu ogwu

Tupu ịmalite iji Zokor, a na-enye onye ọrịa iwu usoro hypocholesterol kwesịrị ekwesị, nke a ga-ahụrịrị n'oge usoro ọgwụgwọ niile.

Shouldbọchị ọ bụla nke ọgwụ (site na 5 ruo 80 mg) kwesịrị ị inụ ya na 1 ọgwụ na mgbede.

N'oge usoro mkpụrụedemede ya, ọnụọgụ ya na-arụ ọ dịkarịa ala, izu anọ. Ogo ị na-anabata kwa ụbọchị bụ 80 mg.

Ndị ọrịa nwere ọrịa obi ischemic ma ọ bụ nnukwu ihe gbasara mmepe ya: 40 mg otu ugboro kwa ụbọchị. Ọgwụ ọgwụ na-amalite n'otu oge ahụ nri na usoro mmega ahụ,
Ọrịa nwere hypercholesterolemia (n’adịghị n'ihe ize ndụ nke ibute ọrịa obi). N'ọnọdụ ụfọdụ (ọ bụrụ na achọrọ mbelata na LDL karịa 45%), enwere ike inye ọgwụ mgbochi mbụ nke 40 mg. Site na ụdị hypercholesterolemia dị nwayọ na oge aga, enwere ike ịmalite usoro ọgwụgwọ kwa ụbọchị 10 mg, ma ọ bụrụ na ọ dị mkpa, jiri nwayọọ nwayọọ mụbaa ya.
Ndị ọrịa nwere hypercholesterolemia homozygous: 40 mg otu ugboro n'ụbọchị ma ọ bụ 80 mg na usoro onwa atọ - 20 mg n'ụtụtụ na ehihie na 40 mg na mgbede.N'okwu a, enwere ike inye Zokor ka ọ bụrụ otu ọgwụ ma ọ bụ na mgbakwunye na usoro ọgwụgwọ ọzọ nke na-ebelata cholesterol (dịka ọmụmaatụ, LDL plasmapheresis).

A na-eji Zokor eme ihe dị ka monotherapy ma ọ bụ na njikọta yana bile acid. N'okwu a, a chọrọ idozigharị dose dabere na ọgwụ ndị ejiri otu oge:

Danazole, cyclosporine, gemfibrozil, fibrates ndị ọzọ (ma e wezụga fenofibrate), liacin (> 1000 mg / ụbọchị): kwa ụbọchị nke Zokor bụ 10 mg,
Verapamil, amiodarone: uzu ubochi ekwesighi gafere 20 mg.

Ndị ọrịa nwere nsogbu gbasara akụrụngwa ebidoghị agafeghị oke. Ọria ndị ọrịa nwere akụrụ gbasara akwara na -emekarị ihe (mejupụtara creatinine na-erughị 30 ml / nkeji) ka akwadoro ịkarịghị ọgwụ kwa ụbọchị nke 10 mg. Ọ bụrụ na ekwesiri ịkpa ụdị mkpa ahụ, ekwesịrị ịgwọ ya n'okpuru nlekọta ahụike kachasị nlebara anya.

Analogs nke Zokor

Ihe analogues nke ogwu a bu ogwu Simvastatin, Avestatin, Simvakard, Simlo, Atherostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Ha na-enye mmetụta yiri nke ahụ, mana ọ bụ naanị ọkachamara kwesịrị ikpebi ọgwụ kachasị mma na nke ọ bụla.

Enweghi ihe omuma banyere uzo eji ogwu a n’ime umuaka, ya mere ejighi ogwu a mee ka umuaka di n’agbata afo iri.

Ejiri Zokor gwọọ ụdị ọrịa hypercholesterolemia gbasara mmekọrịta nwoke na nwanyị nọ n'oge uto. N'okpuru mmetụta nke ọgwụ ahụ, ọkwa nke triglycerides, cholesterol, apolipoprotein B na-ebelata.

A na-agwọ ụmụaka nwanyị nwere ọgwụ naanị ma ọ bụrụ na ịhụ nsọ nwanyị nọ na nwata nwanyị gbara afọ iri atọ gara aga.

Dodoụbiga ya ókè

N'ọtụtụ ọnọdụ ama ama nke ịdoụbiga mmanya ókè (oke kacha - 450 mg), enweghị akara ma ọ bụ mmetụta ọ bụla akọwapụtara. A na-eji ọgwụgwọ Symptomatic eme ihe.

Nchedo nchekwa

Ọnọdụ nchekwa nke ọgwụ Zokor®

Mgbe okpomọkụ adịghị karịa 30 Celsius.

Ekwela ka ụmụaka ghara iru ya.

Ndụ shelf nke ọgwụ Zokor®

10 mg mbadamba ihe mkpuchi - 3 afọ.

mbadamba ihe mkpuchi-20 mg - 3 afọ.

Mbadamba ụrọ dị arọ 10 mg - afọ 3.

Mbadamba mbadamba 20 mg - 3 afọ.

Mbadamba ụrọ 40 mg - 2 afọ.

Mbadamba mbadamba 80 mg - 2 afọ.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Mwepụta wepụtara ya na ihe mejupụtara

E nwere ya n'ụdị mbadamba agba agba: oval, ezigbo n’otu akụkụ, n’akụkụ nke ọzọ - kanye “MSD 735” (mbadamba ụcha pink pink) ma ọ bụ kanye “MSD 740” (mbadamba nke agba aja aja na-acha odo odo) (pcs 14. blisters, 1 ma ọ bụ abụọ na blisters na otu kaadiboodu).

Ihe na-arụ ọrụ bụ simvastatin:

1 mbadamba ụrọ na-acha odo odo - 10 mg,
1 tan mbadamba - 20 mg.

Ndị pụrụ iche: ascorbic acid, butylhydroxyanisole, microcrystalline cellulose, lactose monohydrate, starch pregelatinized, citric acid, magnesium stearate.

Ihe mejupụtara shell: hydroxypropyl cellulose, talc, methylhydroxypropyl cellulose, titanium dioxide, dyes iron oxide odo na iron oxide na-acha ọbara ọbara.

Omume ọgwụ

Site na ntuziaka ahụ, a na-egosipụta Zokor site na nsonaazụ egbugbere ọnụ. Ngwakọta nke mbadamba ahụ gụnyere simvastatin ihe dị n'ọrụ, nke, mgbe ọ gbanwere mmiri, ọ ghọọ ogige dị ike. Metabolite ya na-egbochi enzyme HMG-CoA reductase, nke a na-etinye na biosynthesis mbụ nke cholesterol.

N'ihi nke a, iji ọgwụ ahụ enyere aka belata mkpokọta cholesterol n'ime ahụ, yana ọkwa cholesterol na-emetụta obere lipoproteins dị ala. Oke nke cholesterol na plasma nke triglycerides belatara belata.

N'otu oge, mgbe ị na-ewere Zokor, ọdịnaya nke cholesterol nke metụtara oke lipoproteins dị elu na-abawanye nke ukwuu. A na-eji ọgwụ ahụ maka ụdị hyperlipidemia dị iche iche, gụnyere ndị na-abụghị ezinụlọ, ezinụlọ, heterozygous. Edere ya maka ụdị hyperlipidemia agwakọtara n'ọnọdụ ndị ahụ mgbe ị na-eji nri, ọ gaghị ekwe omume ịhazi mkpokọta lipids na plasma.

Plasma lipid na-ebelata ụbọchị iri na anọ ka ebidochara usoro ọgwụgwọ. Onu ogugu ha rutere nke oma na izu nke ano na isii. Site na ijiziwanye ọgwụ a, echekwa nsonaazụ a.

Mgbe emechara ọgwụgwọ, ihe ndị na-egosi kọlestọl dị na plasma ji nwayọ laghachi na nke mbụ, bụ nke kpebisiri ike tupu mmalite ọgwụ.

Pharmacodynamics na pharmacokinetics

Edebere oke mkpokọta nke simvastatin metabolites n’ime ọbara bụ 1.3-2.4 awa mgbe ị nwesịrị otu ọgwụ nke Zocor. Ihe dị ka 85% nke ihe ndị dị ike dị na mbadamba nkume ahụ na-abanye n'ime ahụ mgbe a na -ewere ya ọnụ.

Mgbe ejiri ọgwụ mee ya, a na-ahụ ọkwa dị elu nke simvastatin na imeju ma e jiri ya tụnyere anụ ahụ ndị ọzọ. N'ihi “uzo mbu” nke ihe site n’arụ, ọ na - eme ya ka ọ gwọọ ya, emesia ọgwụ ahụ na metabolites ya n’arụpụ.

Ceptionnabata Zokor adabereghị na iji nri, nke anaghị emetụta ọgwụ ọgwụ. Ogologo oge ọgwụgwọ adighi eduga na mkpo simvastatin na anụ ahụ.

Ihe ngosi maka ojiji

Edere Zocor nye ndị ọrịa nwere ọrịa obi na -akpata (CHD) ma ọ bụ nwee ọrịa a, yana ndị ọrịa nwere nnukwu ihe ibute ọrịa obi (gụnyere ọnụnọ hyperlipidemia), dịka ọmụmaatụ, ndị ọrịa nwere ọria mellitus, ndị ọrịa nwere ọrịa vaskụla, ọnya afọ ma ọ bụ ọrịa ndị ọzọ ọrịa kansa. na anamnesis. Ebumnuche nke ọgwụ:

Mbelata ihe ize ndụ nke ọnwụ n'ihi ọrịa obi obi.
Mbelata ihe ọghọm nke ibute ọrịa obi ma ọ bụ nsogbu akwara, dịka ọrịa strok, infarction myocardial na-abụghị nke na - egbu egbu, ọbara ọgbụgba,
Mbelata ihe ize ndụ nke ụlọ ọgwụ maka ọgụ angina,
Mbelata ohere nke ịwa ahụ n'ihi mkpa ọ dị maka iweghachi ọbara ọgbụgba ma ọ bụ ụdị nnwale ndị ọzọ.

Ọzọkwa, na ngalaba ndị ọrịa edepụtara, ka edepụtara ọgwụ ahụ ma ọ bụrụ na ọ dị mkpa iji duzie ọrụ mmụghachi.

Na mgbakwunye, a na-enye Zokor maka hypercholesterolemia - dị ka mgbakwunye na nri ahụ n'ọnọdụ ebe nri nri na ụzọ ọgwụgwọ ndị ọzọ na-abụghị ọgwụ si ezughị. Ebumnuche nke ọgwụ:

Ọgwụgwọ ụdị hyperlipidemia nke IV dịka nkewa Fredrickon (hypertriglyceridemia),
Ọgwụ nke ụdị III hyperlipidemia dabere na nhazi nke Fredrickson (dysbetalipoproteinemia),
Cholesterol dị elu, obere lipoprotein (LDL) dị ala, kọlipopolatte B na triglycerides dị elu,
Cholesterol dị elu nke lipoproteins dị elu (HDL) na ndị ọrịa nwere hypercholesterolemia bụ isi, gụnyere ụdị IIa hyperlipidemia dị ka nkewa Fredrickson (heterozygous familial hypercholesterolemia) ma ọ bụ ụdị II hyperlipidemia dị ka nkewa Fredrickon (hypercholesterolemia agwakọta),
Mbelata ihe ruru cholesterol na HDL cholesterol, yana LDL kọlesterol rue HDL kọlesterol,
Mbelata ọkwa dị elu nke cholesterol ngụkọta, LDL cholesterol na apolipoprotein B na ndị ọrịa nwere hyzycholesterolemia homozygous familial (na mgbakwunye na nri na ọgwụgwọ ndị ọzọ).

N'ime ndị ọrịa nwere ọrịa mellitus nke ọrịa shuga, Zokor na-ebelata ihe ize ndụ nke nsogbu akwara sitere na vaskụla (gụnyere ohere ọnya trophic ọnya, ịtụgharị ya na mgbatị nke mpaghara ala).

N'ime ndị ọrịa nwere ọrịa obi, tinyere cholesterol dị elu, ọgwụ ahụ nwere ike belata ihe ize ndụ nke ịmalite ọrịa akwara na-arịa atherosclerosis, gụnyere ọdịdị nke nsogbu na mmerụ ọhụụ.

Ihe ngbanwe

Mmụba na-aga n'ihu na ọkwa nke ọrịa hepatic na plasma ọbara nke etiology na-amaghị,
Ọrịa imeju na-arụ ọrụ
Ime na oge atụmatụ
Lactation
Onwe onye n’onwe ya na mejuputa ogwu ahu.

N'ihi enweghị data nchekwa banyere iji simvastatin na ọgwụ ụmụaka, a gaghị atụ aro ka inye ụmụaka ọgwụ ahụ.

Akuko nke rhabdomyolysis,
Ọrịa shuga mellitus
Mmụba na-aga n'ihu na ọkwa ọbara transaminases (ọ bụrụ na ọ gafere oke iwu ugboro atọ, ịkagbu ọgwụ ahụ),
Okpu akuko gbasara akwara obi (mebiputara opekata mpe 30 ml / min),
Abuse abuseụbiga mmanya ókè.

Ntụziaka maka iji Zokora: usoro na usoro onunu ogwu

Tupu ịmalite iji Zokor, a na-enye onye ọrịa iwu usoro hypocholesterol kwesịrị ekwesị, nke a ga-ahụrịrị n'oge usoro ọgwụgwọ niile.

Shouldbọchị ọ bụla nke ọgwụ (site na 5 ruo 80 mg) kwesịrị ị inụ ya na 1 ọgwụ na mgbede.

N'oge usoro mkpụrụedemede ya, ọnụọgụ ya na-arụ ọ dịkarịa ala, izu anọ. Ogo ị na-anabata kwa ụbọchị bụ 80 mg.

Ndị ọrịa nwere ọrịa obi ischemic ma ọ bụ nnukwu ihe gbasara mmepe ya: 40 mg otu ugboro kwa ụbọchị. Ọgwụ ọgwụ na-amalite n'otu oge ahụ nri na usoro mmega ahụ,
Ọrịa nwere hypercholesterolemia (n’adịghị n'ihe ize ndụ nke ibute ọrịa obi). N'ọnọdụ ụfọdụ (ọ bụrụ na achọrọ mbelata na LDL karịa 45%), enwere ike inye ọgwụ mgbochi mbụ nke 40 mg. Site na ụdị hypercholesterolemia dị nwayọ na oge aga, enwere ike ịmalite usoro ọgwụgwọ kwa ụbọchị 10 mg, ma ọ bụrụ na ọ dị mkpa, jiri nwayọọ nwayọọ mụbaa ya.
Ndị ọrịa nwere hypercholesterolemia homozygous: 40 mg otu ugboro n'ụbọchị ma ọ bụ 80 mg na usoro onwa atọ - 20 mg n'ụtụtụ na ehihie na 40 mg na mgbede. N'okwu a, enwere ike inye Zokor ka ọ bụrụ otu ọgwụ ma ọ bụ na mgbakwunye na usoro ọgwụgwọ ọzọ nke na-ebelata cholesterol (dịka ọmụmaatụ, LDL plasmapheresis).

A na-eji Zokor eme ihe dị ka monotherapy ma ọ bụ na njikọta yana bile acid. N'okwu a, a chọrọ idozigharị dose dabere na ọgwụ ndị ejiri otu oge:

Danazole, cyclosporine, gemfibrozil, fibrates ndị ọzọ (ma e wezụga fenofibrate), liacin (> 1000 mg / ụbọchị): kwa ụbọchị nke Zokor bụ 10 mg,
Verapamil, amiodarone: uzu ubochi ekwesighi gafere 20 mg.

Nsonaazụ

Usoro nri: dyspepsia (afọ ọsịsa, ọgbụgbọ na ọgbụgbọ), adịkarịghị - pancreatitis, jaundice, ịba ọcha n'anya,
Sistemụ akwara Central: vertigo, neuropathy akụkụ,
Usoro akwara: myalgia, rhabdomyolysis,
Ọrịa Allergic na immunopathological: lupus-like syndrome, angioedema, polymyalgia rheumatism, mụbara ESR, eosinophilia, ogbu na nkwonkwo, thrombocytopenia, ogbu na nkwonkwo, vasculitis, urticaria, akpukpo anụ ahụ, photoensitivity, mkpụmkpụ ume, fever, feverise General.
Mmeghachi omume oria: akpukpo aru, itching, dermatomyositis, alopecia,
Ndị ọzọ: akwara mgbu, paresthesia, ọrịa ịba, anaemia,
Ihe ngosi ulo oru: ogo nke transaminases, alkaline phosphatase na gamma-glutamyl transpeptidase, creatine phosphokinase.

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga mmanya ókè, a na-eji usoro ọgwụgwọ ọdịnala merie nsonaazụ nke ahụ.

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ ndị a na-eji simvastatin (ọkachasị na oke ọnụọgụ) na-abawanye ohere nke myopathy / rhabdomyolysis:

Ihe na - egbochi CYP3A4 inhibitors: clarithromycin, erythromycin, telithromycin, ketoconazole, nefazodone, itraconazole, immunodeficiency virus protease inhibitors,
Ọgwụ ndị ọzọ na-egbusi ike na-adịghị ike na-egbochi CYP3A4, mana nke nwere ike ibute mmepe nke myopathy: gemfibrozil na fibrates ndị ọzọ (ewezuga fenofibrate), niacin (nicotinic acid) na usoro nke iji egbugbere ọnụ (> 1 g / ụbọchị),
Cyclosporin, danazole,
Amiodarone, verapamil,
Diltiazem.

Simvastatin, nke a na-eji kwa ụbọchị nke 20-40 mg, na-eme ka mmetụta nke coumarin anticoagulants ma na-abawanye ohere ọbara ọgbụgba: oge prothrombin (International Normalized Ratio) na-abawanye site na ọkwa mbụ nke 1.7 ruo 1.8 na ndị ọrụ afọ ofufo ahụike, yana ndị ọrịa nwere hypercholesterolemia - site na 2 , 6 ruo 3.4. Iji wepu mgbanwe ndị dị mkpa na njirimara a, ndị ọrịa na-anakwere ọgwụ coumarin anticoagulants, oge prothrombin kwesịrị ikpebi tupu ịmalite ojiji nke Zokor na oge site na oge ọgwụgwọ mbụ. Mgbe akara ngosi INR kwụsịrị, a ga-emerịrị mkpebi ya karịa oge a tụrụ aro maka ileba anya ndị ọrịa na-agwọ ọrịa anticoagulant.

Ihe ọ juiceụụ mkpụrụ osisi grepu nwere opekempe otu ihe na - egbochi CYP3A4 ma nwekwa ike ịbawanye ọkwa plasma nke ọgwụ enzyme a. Iji otu iko ihe ọ 1ụ 1ụ (250 ml) kwa ụbọchị enweghị ihe ọ bụla metụtara ọgwụgwọ. Agbanyeghị, mgbe ị na-a largeụ nnukwu mmiri ihe ọ (ụ (ụ (ihe karịrị 1 lita kwa ụbọchị) n'oge ọgwụgwọ na simvastatin, ọkwa plasma nke ọrụ HMG-CoA reductase inhibitors na-abawanye. Maka nke a, ekwesighi ị beụ mmiri mkpụrụ osisi grape n'oge ọgwụgwọ.

Analogs nke Zokor bụ: Simvastatin, Simvastatin Zentiva, Avestatin, Simvakard, Simlo, Aterostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

N'oge ime na lactation

Ihe ogwu a ka contraindicated na oge nke afọ ime na inye nwa mmiri ara ara. Mgbe ị na-ewere simvastatin n’oge afọ ime, a ga-ahụta nsogbu ndị dị n’usoro mmepe nke nwa ebu n’afọ.

N'oge ọ dị mkpa, itinye ya n'ọrụ Zokor, ịkwesịrị ịkwụsị inye nri.

Nyocha banyere Zokora

Ọtụtụ ihe nyocha mara banyere Zokora, na-egosi ịdị irè nke ọgwụ ahụ. Ngwakọta ya na-arụ ọrụ n’ezie na-enyere aka belata cholesterol. Agbanyeghị, iji nweta nsonaazụ a tụrụ anya ya, a na-atụ aro ka iji ọgwụ ahụ eme ihe maka oge nke dọkịta na-ahụ maka ịga. Ndị ọrịa na-akọ nsonaazụ dị mma mgbe ha na-eji simvastatin dị ka ihe mgbochi.

Ngwakọta, ụdị ntọhapụ

A na-ahapụ Zokor n'ụdị mbadamba mkpuchi. Ha bụ oval, peach (10 mg) ma ọ bụ tan (20 mg) na agba.

Otu mbadamba Zocor nwere 10 ma ọ bụ 20 mg nke simvastatin. A na-arụ ọrụ inyeaka site na: ascorbic acid, citric acid, butylhydroxyanisole E320, cellulose, stachi, magnesium sterete, shuga mmiri ara ehi. Mpekere nke mbadamba ihe mejupụtara cellulose, hypromellose, titanium dioxide (E 171), talc, odo, ọla edo na-acha ọbara ọbara (E172, E171).

Zokor: ngosipụta maka ojiji

Dịka ntuziaka ahụ si dị, enyekwara Zokor ndị ọrịa nwere ihe ketara eketa ma ọ bụ enwetara hypercholesterolemia mgbakwunye na nri, mgbe naanị ya ezughị:

wedata na ịta nke OH, X-LDL, TG, apolipoprotein B,
mmụba na HDL-C n’ime ndị ọrịa nwere hyperlipidemia IIa / IIb,
na -ebelata ogo nke X-LDL / X-HDL, OH / X-HDL,
ala triglycerides.

Egosiputara mbadamba Zokor maka ndi mmadu n’enwe oke nsogbu nke oria obi: ya na oria mellitus, oria ma obu oria ozo, oria akwara. Nmata metabolism nke cholesterol, yana abụba ndị ọzọ na - akpata, na - enyere aka igbochi mmepe nke nsogbu.

Ofzọ nke ngwa, usoro onunu ogwu

Edere ọgwụ Zokor naanị ka ọ gachara usoro ọgwụgwọ iji gboo ọkwa cholesterol. Ofdị mbadamba ọrụ na-esote na-adabere na ịdọ aka ná ntị onye ọrịa. Ọ bụrụ na ọ raparaghị na nri, a ga-ebelata ya na efu.

Kwa ụbọchị nke Zokor bụ 5-80 mg. A na-ewere mbadamba otu ugboro / ụbọchị, na mgbede, yana nnukwu mmiri. Nri anaghị emetụta mmịpụta nke ọgwụ. Yabụ, enweghị mkpa ịhazi nri ị nweta Zokor na nri.

Nhọpụta nke ọgwụ na-amalite site na obere opekempe, nke a ga-enyocha ka ụbọchị 28 gachara.

Ndị ọrịa nwere ọrịa obi ischemic / ihe egwu dị ukwuu nke mmepe ya, ka edepụtara ọgwụ ahụ na usoro mbụ nke 40 mg / ụbọchị. Maka ndị ọrịa ndị ọzọ nwere hypercholesterolemia, usoro ịmalite amalite na-abụkarị 20 mg / ụbọchị.

Site n'ọdịdị ketara eketa nke nsogbu cholesterol metabolism, a na-enye Zokor iwu na 40 mg / ụbọchị (otu ugboro) ma ọ bụ 80 mg / ụbọchị (ugboro atọ: 20 mg n'ụtụtụ, ehihie, 30 na mgbede).

Ohere nke ịdebe mbadamba nkume maka ụmụaka 10-17 afọ nwere ọrịa hyperlipidemia nke ezinụlọ. N'ime ọmụmụ ahụ, otu ìgwè ụmụaka kpọọrọ Zokor maka izu iri anọ na asatọ, yana nke abụọ. Onweghi ihe di iche na anagide ihe. Mana maka nkwubi okwu na-enweghị isi, ọ dị mkpa iji duzie nnwale ogologo oge ma nyochaa mmetụta ọgwụ nwere na mmepe uche na mmekọahụ.

1. Ntụziaka maka ojiji

Inweta Zokor kwesịrị inwe nri ga - agbada cholesterol. Edere ndị ọrịa site na 5 ruo 80 mg nke ọgwụ maka iji ya kwa ụbọchị tupu ụra. Ọ gaghị ekwe omume ịgafe ụkpụrụ kachasị. A na-ahọrọ oke dị mma n’otu n’otu, mgbanwe ọ bụla na ọnụego akwadoro nke Zocor ka ana-eme karịa otu ugboro n’ọnwa.

Ọgwụgwọ ahụ kwesịrị ịdị ogologo oge, mgbe ewepụrụ ọgwụ ahụ, onye ọrịa laghachiri n'ọnọdụ mbụ ya.

Usoro ogwu nke ogwu maka oria di iche iche bu dika ndi a:

Ọrịa Ischemic, ọrịa shuga mellitus, ọrịa strok - 40 mg kwa ụbọchị, n'otu oge ahụ, ịkwesịrị ịgbaso nri ma tinye aka na nkuzi anụ ahụ,
Hypercholesterolemia - na ụdị ọrịa ahụ, a na-atụpụta 10-20 mg kwa mgbede ma ọ bụrụ na ọ dị mkpa iji belata ọkwa LDL karịa karịa 45% –40 mg,
Hypercholesterolemia ezinụlọ - a na-atụ aro ịmalite ọgwụgwọ na 40 mg nke ọgwụ na mgbede ma ọ bụ 80 mg ugboro atọ n'ụbọchị (20 + 20 + 40 n'otu oge).

Ọ bụrụ na edeputara Zokor ọnụ na Danazol, Cyclosporin, Gemfibrozil na fibrates ndị ọzọ ma ọ bụ Niacin, ego kachasị kwa ụbọchị ekwesịghị ịkarị 10 mg.

Na Verapamil ma ọ bụ Amiodarone, ọnụ ahịa a bụ 20 mg. A na-atụ aro ka ndị ọrịa nwere nnukwu akụrụ siri ike belata ọnụego ụbọchị kwa ụbọchị na 10 mg.

3. Ngwongwo bara uru

Edere Zokor maka ndị ọrịa na-arịa ischemic ọrịa obi ma ọ bụ nwee ọrịa a, hypercholesterolemia n'ụdị dịgasị iche iche, yana ọrịa shuga mellitus.

Ọgwụ nwere ihe ndị a:

ọgụ mgba nke mgbaàmà nke obi nkụchi akpati,
na-ebelata ohere mmadụ nwere ịnwụ n'ihi ọrịa obi,
na - egbochi mmepe nke nnukwu nsogbu akwara, - obi ọgụ, wdg),
na -ebelata mkpa maka nrụpụta arụmọrụ ọbara na ụdị ọbara ọgbụgba ndị ọzọ,
emesi angina ọgụ,
lowers mkpokọta cholesterol, LDL na B-lipoprotein,
na-abawanye HDL (cholesterol bara uru),
na-achịkwa ọkwa triglyceride.

Na ọrịa shuga mellitus, Zokor na-egbochi ọdịdị nke mmerụ ahụ na arịa ime ala, ma ọ bụrụ na ọrịa akwara ọbara na hypercholesterolemia ọnụ ọ na-egbu oge mmepe nke akwara na atherosclerosis na nsogbu ndị ọzọ.