Amikacin - ntuziaka maka ojiji nke ọgwụ nje na ntụ na ngwọta

Ọgwụ a bụ ọgwụ mgbochi ọgwụ aminoglycosides, nke nwere ụdị dịgasị iche iche nke ọrụ ahụhụ. Isi onye na-emepụta ọgwụ bụ Synthesis. A na-ewepụta ya na ụlọ ahịa ọgwụ naanị ọgwụ ọgwụ ma enweghị ike ịhapụ ya na-enweghị ya. Erere dika uzo osisa ma obu mmanu aru maka ochichi intramuscular ma obu mgbochi ogwu.

Ntụziaka maka iji Amikacin

Ọgwụ nje Amikacin bụ ọgwụ semisynthetic sitere na otu aminoglycoside. Ọgwụ ahụ na-emetụta microorganisms bacteriostatically, bactericidal, na-egbochi usoro nke ndụ ha, na-eduga ọnwụ nke nje. Na gburugburu pathogenic, iguzogide ọgwụ na-amalite nwayọ nwayọ, yabụ, ọgwụ ahụ nwere ọnọdụ kachasị na arụ ọrụ na otu nke aminoglycosides. Ọgwụ dị n'ọbara ọgwụ mgbochi ọrịa, ọ na - arụ ọrụ ike megide:

Microfọdụ microorganisms gram-gram-staphylococci (staphylococcus), nke na-eguzogide methicillin, cephalosporins, penisilini, ụfọdụ ụdị nke streptococci (streptococcus).
Gram-ọjọọ: Aeruginosa, Enterobacter, Escherichia, Klebsiella, Ilu>

Ngwakọta na ụdị ntọhapụ

A na-eme nkwadebe ahụ n'ụdị edozi ma ọ bụ ntụ ntụ iji kwadebe ihe ngwọta. A na-enye ọgwụ ahụ intramuscularly ma ọ bụ intravenously, dị na usoro ndị a:

Ampoules 2 ml nke 500 mg (250 mg / 1 ml), mkpọ nke 5 ma ọ bụ 10 iberibe,
Ampoules 4 ml nke 1 g nke 5 na 10 PC. mbukota
ntụ ntụ n'ime karama 500 na 1000 mg, nkwakọ 1, 5, 10 PC.

Na mpụga, ọgwụ bụ ụzọ doro anya, enwere isi ihe ndị ọzọ na ndị ọzọ:

isi ihe na - arụ ọrụ bụ amikacin, ml nwere 250 mg,
ihe inyeaka - sodium citrate, mmiri maka injection, sọlfọ acid diluted, sodium disulfite.

Pharmacodynamics na pharmacokinetics

Nke a bụ ọgwụ nje sitere na ọgbọ aminoglycoside nke atọ. Ọ nwere nsonaazụ bacteriostatic (na-egbu mkpụrụ ndụ nke nje) na njikọta ọtụtụ microorganisms pathology dị iche iche. Mbibi sel na - eme n'ihi ịdabere na subS nke 30S nke ribosome, na - emeghasị akụkụ nke mkpụrụ ndụ protein, nke na - akpata ọnwụ nke mkpụrụ ndụ. Ọgwụ a na-arụ ọrụ megide ọtụtụ microorganisms gram-positive na ụfọdụ gram-negative.

Ọgwụ ahụ enweghị mmetụta ọ bụla na nje nje anaerobic (ụmụ nje ndị ahụ nwere ike ịmalite naanị na enweghị oxygen). Amikacin bụ ọgwụ dị irè megide nje na-eguzogide ọgwụ nje na ọgwụ nje ndị ọzọ. Mgbe ịgba ọgwụ intramuscular gasịrị, ọgwụ ọgwụ ahụ na-abanye n'ọbara ọbara ngwa ngwa ma kesaa ahụ niile na minit 10-15. Ọgwụ na-abanye n’ụzọ mgbochi ọbara - ụbụrụ, n’ọbara (n’oge ime, baa n’ime ahụ nwa ahụ), na-abanye n’ime mmiri ara. Ahụ ha anaghị agbanwe agbanwe.

Ihe ngosi maka ojiji

Isi ihe eji eji ọgwụ nje eme ihe bụ nnukwu ọrịa na-efe efe nke nje na-akpata gram na-adịghị mma (karịchaa ma ọ bụrụ na ha na-eguzogide ọgwụ ndị ọzọ na otu a). Ọrịa ndị a bụ ihe ngosipụta maka ojiji nke ọgwụ:

Filiks nke nje na - efe efe nke akụkụ okuku ume: akwara umeji, akwara nje na-efe efe, ka oyi baa, nsogbu nke pleura (nnụnnụ nke ahụhụ na oghere agụụ).
Sepsis. Nke a bụ usoro na - efe efe nke nwere ike na uto nke nje nje pathogenic n'ime ọbara.
Ọrịa ụbụrụ: meningitis, meningoencephalitis, encephalitis.
Ọrịa bakteria endocarditis. Usoro nje na –emekarịkarị ihe dị n'ime obi.
Ọrịa nke anụ ahụ, anụ ahụ dị nro, anụ ahụ dị n'okpuru ala: phlegmon, ọnya afọ, ọnya nrụgide na necrosis, usoro gangrenous, ọkụ.
Peritonitis na usoro nje ndị ọzọ na-akpata ọrịa na oghere dị n'ime afọ.
Ọrịa na-efe efe na akụkụ ọmụmụ, usoro urinary - etuto nke eriri, akwara, empyema nke ọnya afọ, cholecystitis.
Osteomyelitis (ọnya ọkpụkpụ), ọrịa ogbu na nkwonkwo.
Ọrịa ndị na-emetụta eriri afọ, afọ.

Usoro onunu ogwu na nhazi

Tupu ịkọwa ọgwụ, dọkịta ga-emerịrị usoro nchọpụta ọ bụla dị mkpa. A malitere usoro onunu ogwu, usoro nke itinye ihe n'ọrụ, na-eburu n'uche nsonaazụ nke ọrịa ahụ, ogo ọgbụgba ahụ, yana mmetụta nke pathogen. Enwere usoro nchịkwa nke intramuscular na intravenous (ntapu ma ọ bụ jet maka awa 2).

Amikacin intravenously

Theta ọgwụ ahụ na ihe ngwọta maka injection intravenously enweghị ike karịa 5 mg / ml. Ọ bụrụ na ọ dị mkpa, enwere ike iji ọgwụgwọ Amikacin mee ihe, nke a na-eji maka nchịkwa intramuscular. Achọrọ 5% glukos nke 200 ml ma ọ bụ isotonic sodium chloride solution. A na-eme ntinye mmiri na ọsọ nke 60 tụlee / nkeji, ugboelu - maka nkeji 3-7. Ọ dị mkpa n'oge ọgwụgwọ iji nyochaa ọrụ nke auditory akwara, akụrụ, vestibular ngwa.

Amikacin intramuscularly

A na-edozi ihe ngwọta site na ịgbakwunye mmiri maka ntụtụ na ntụ ntụ na vial. Ọ bụrụ na ọ dị mkpa, injection intramuscular ga-achọ 2-3 mmiri mmiri kwa 05 g nke ntụ ntụ. Mgbe ị na-ewebata mmiri, a ga-ahụrịrị ntụpọ. Ikwanye karama ahụ ka ihe ndị dị n’ime ya gbazee nke ọma na mmiri. Mgbe nke ahụ gasị, tinye ihe nrịba ahụ na sirinji ma mee ntụtụ intramuscular.

Ntụziaka pụrụ iche

Enwere ụfọdụ ndepụta iwu nke ekwesịrị ịtụle mgbe ị na-eji ọgwụ. Naanị dọkịta na-edepụta ya yana iwu ji onye ọrịa ahụ irube isi n'usoro onye ọkachamara ọkachamara ahụ nyere ya. Ndụmọdụ ndị pụrụ iche ndị a:

Maka ụmụaka ruo ọnwa 1 na ụmụ amụrụ ọhụrụ, enwere ike inye ọgwụ ahụ naanị n'okpuru nlekọta ahụike siri ike, ma, ọ bụrụ na achọrọ oke, dose 10 mg / n'arọ ibu. Usoro onunu ogwu ekewa n’ime ubochi iri.
N’ebe enweghị mmetụta ọgwụgwọ, ụbọchị 2-3 ka mmalite nke ọgwụgwọ gasịrị, a ga-eme mkpebi iji dochie usoro ọgwụgwọ nke ọrịa ma ọ bụ ọgwụ nje.
Ekwesịrị iji akọ mee Amikacin na ọgwụ ndị ọzọ, ọ dị mkpa iji nyochaa ọrụ ọrụ akụrụ, imeju na usoro ụjọ.
N'okpuru nchịkwa siri ike, a na-eji ọgwụ ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa ogbu na nkwonkwo, myasthenia gravis (adịghị ike akwara).

Amikacin n’oge di ime

Anabatara iji ọgwụ ahụ maka ihe ịrịba ama dị mkpa n'oge ime, lactation. Ekwesịrị iburu n'uche na ọgwụ ahụ nwere ike ịbanye na Plasenta, mgbe ahụ, a hụrụ ya n'ọbara nwa ebu n'afọ, enwere ihe ize ndụ nke ịkpakọba ihe dị na akụrụ nke nwatakịrị ahụ, nke nwere mmetụta nephro na mmetụta ototoxic na ha. Ekpebie ya n’obere nsi na mmiri ara ara. Site na eriri afọ, nnabata nke aminoglycosides adịghị ike. Mgbe a na-ahụta nsogbu ara ara n’ihi ị medicationụ ọgwụ n’ime ụmụaka.

Amikacin maka ụmụaka

Edere ndenye ọgwụ ọgwụ site na mgbe a mụrụ ya. A na-eji Amikacin maka ụmụaka dịka ndị a:

umu agbogwo: ogwu nke mbu bu 10 mg / kg, mgbe ahu 7.5 mg kwa awa 24,
congenital na ruo afọ 6: ntụtụ mbụ bụ 10 mg / kg, mgbe ahụ 7.5 mg kwa elekere 12 ọ bụla.

Ruo ọkara otu awa, a na-enye ụmụaka ọgwụ ahụ n'ụzọ ọbara, n'ọnọdụ ndị siri ike otu awa. Site na mmepe nke ọrịa siri ike, a na-ahapụ nchịkwa jet maka nkeji 2, mana naanị na ọnụnọ dọkịta na ikike ya. Tupu iji ngwaahịa ahụ, a na-agwakọta ya na ihe ngwọta nke sodium chloride (0.09%) ma ọ bụ dextrose (5%). N'ihi nke a, itinye uche nke ihe nọ n'ọrụ ekwesịghị gafere 5 mg kwa 1 n'arọ nke oke.

Mkparịta ụka ọgwụ ọjọọ

Amikacin na-emekọrịta ihe mgbe ya na benzylpenicillin, carbenicillin, cephalsporins na-emekọrịta ihe (enwere ohere nke belata ịdị mma nke aminoglycosides mgbe ejikọtara ya na ọgwụ mgbochi beta-lactam na ndị ọrịa nwere nnukwu akụrụ renal ọdịda). Ihe ọghọm nke oto- na nephrotoxicity na-abawanye mgbe gị na polymyxin B na-emekọrịta, nalidixic acid, vancomycin, cispalitic.

Penicillins, cephalosporins, diuretics (ọkachasị furosemide), NSAIDs, sulfonamides mepụtara asọmpi maka nzuzo nzuzo na tubules nke nephron. Nke a na - eduga na iwepu mkpochapu aminoglycosides, mee ka itinye uche ha na ọbara, mụbaa neuro- na nephrotoxicity. Amikacin mgbe ị na-eme ọgwụ na ọgwụ ogwu curare na-akwalite mmetụta izu ike akwara.

Ihe ọghọm nke njide akụkụ iku ume n'oge ịmịnye ọbara na ndị na-echekwa citrate, iji ọgwụ ndị na-egbochi nnyefe akwara ma na-a Amụ Amikacin. Site na nchịkwa parenteral nke indomethacin, ihe ize ndụ nke nsonaazụ nke aminoglycosides na-abawanye. Ọgwụ na-ebelata mmetụta nke ọgwụ mgbochi myasthenic. Amikacin ekwekọghị na heparin, penicillins, cephalosporins, amphotericin B, capreomycin, erythromycin, vitamin nke otu C, B, potassium chloride.

Nsonaazụ nke Amikacin

Ihe inyeaka ma ọ bụ sọlfọ amikacin mgbe ebuputachara n’ime ahụ nwere ike ibute nsonaazụ na-adịghị mma. Otu n'ime mmeghachi omume ọjọọ ndị a na-enwekarị bụ:

Site na eriri afọ, a na-ahụwanye mmụba nke enzymes imeju AST na ALT n'ọbara, nke na-egosi mbibi nke mkpụrụ ndụ imeju (hepatocytes), mmụba nke mkpokọta bilirubin n'ọbara, ọgbụgbọ na ọgbụgbọ.
Mmeghachi omume nfụkasị. Odi onodu ozo di iche, site na itching na nchapu rue ure anaatlactic (ihe di omimi nke otutu okpu n'ihi oke obara). Ngosiputa ozo puru ime bu urticaria (obere ihe nwuru na ọnya n ’akpukpo aru nke yiri udiri ahihia), ekpukpu nke Quincke, na ahu oku.
Mmeghachi omume ọjọọ sitere na haemopoiesis gosipụtara n'ụdị leukopenia (mbelata ọnụ ọgụgụ nke leukocytes), thrombocytopenia (mbelata ọkwa nke platelet), anaemia (mbelata n'ọkwa haemoglobin, ọkwa nke sel ọbara).
Site na usoro mkpụrụ ndụ, mmepe nke ọdịda akụrụ, albuminuria (protein dị na mmamịrị), microredituria (obere ọbara na mmamịrị) nwere ike ịhụ.

Dodoụbiga ya ókè

Ikwesiri ị theụ ọgwụ ahụ nke ọma na usoro ọgwụgwọ dọkịta nyere. Ọ bụrụ na imebi ndụmọdụ ndị ahụ, nwere ike ibute mmetụta ọjọọ ọ bụla. A na-eme ọgwụgwọ gabigara ókè na nlekọta dị ukwuu. Jiri ọgwụgwọ ịba ọcha n'anya, ọgwụgwọ Symptomatic iji wepu ọgwụ ahụ n'ahụ. Ihe iriba ama ama nke nnabata

oké iwe,
ọgbụgbọ, ọgbụgbọ, akpịrị ịkpọ nkụ,
ataxia - ihe ga - eme ka nsogbu gharazie agazi,
ume iku ume na ume iku ume,
nsogbu nke urination
na-akụ ntị, ntị a na-ahụ ụzọ mbelata nke ịnụ ntị gị.

Ihe ngbanwe

Ọgwụ nwere mmetụta dị ukwuu n'ahụ ahụ, ya mere na-enye ya ọgwụ site na ọgwụ na ọgwụ. Usoro mgbochi maka ị theụ ọgwụ bụ ọnọdụ ndị a:

Nkwekorita nke mmadu na amikacin sulfate, mmeghachi ahu nfụkasị ahu na ihe inyeaka.
Ọrịa nke ntị dị n'ime, tinyere ọnya nke akwara ozi. Ọgwụ nwere ike ibute nkwarụ ma ọ bụ na-anụ ihe n'ihi mmerụ ahụ na-egbu egbu.
Ọrịa siri ike nke akụrụ, imeju, bụ nke enweghị ike ha so ya.
Ime

Usoro ire na ebe nchekwa

Inwere ike chekwaa ọgwụ a ka ejiri afọ atọ kpuchie ya. Ekwesịrị idobe ọgwụ ọjọọ a n'ebe akọrọ, ọchịchịrị na ebe dị jụụ n'enweghi ohere iji nweta ụmụaka. Akpadoro udu ikuku ka akwadoro +25 ogo Celsius. A na-ere ọgwụ ọgwụ na pharmacies na ụlọ ahịa dị n'ịntanetị.

Enwere ọgwụ nke nwere otu ihe eji arụ ọrụ. Ha nwere mmetụta yiri ya na Amikacin. N'ime nhọrọ ndị a ma ama bụ ọgwụ ndị a: