Mildronate® (capsules, 250 mg) Meldonium

Otu capsule dị 1:

ihe na - arụ ọrụ - meldonium dihydrate 250 mg,

ndị mgbe ochie - stachi nduku, colloidal silicon dioxide, calcium stearate, capsule (ahụ na mkpuchi) - titanium dioxide (E 171), gelatin.

Hard gelatin capsules Nke 1 nke agba ọcha. Ọdịnaya bụ ntụ dị ọcha nke nwere akwa na-ada mba. Ntụ ntụ ahụ bụ hygroscopic.

Mlọ ọgwụ

Meldonium bụ ihe ntụzi aka nke carnitine, analog nke gamma-butyrobetaine (GBB), bụ ihe a na-ahụ n’ime sel niile n’ahụ mmadụ.

N'okpuru ọnọdụ nke ịba ụba, meldonium na-eweghachi nguzozi n'etiti nnyefe na ikuku oxygen chọrọ nke mkpụrụ ndụ, na-ewepụ nchịkọta ngwaahịa metabolic na-egbu egbu na mkpụrụ ndụ, na-echebe ha pụọ ​​na mbibi, na-enwekwa tonic. N'ihi ojiji nke ahụ, nguzogide anụ ahụ na-akpata nchekasị na ikike iweghachi ikike nchekwa ngwa ngwa.

Ọgwụ nwere mmetụta na-akpali akpali na sistemụ akwara Central (CNS) - mmụba na ọrụ moto na ntachi obi anụ ahụ. N'ihi njirimara ndị a, a na-ejikwa MILDRONAT® iji bulie arụ ọrụ anụ ahụ na nke uche.

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ ngwa ngwa, bioavailability bụ 78%. A na-enweta ntinye uche kachasị na plasma 1-2 awa mgbe nchịkwa gasịrị. Metabolized na ahụ na nguzobe nke isi abuo

metabolites ndị nke dị n’akịrị. Ndụ ọkara ọkara mgbe a na -ewere ya ọnụ bụ 3-6 awa.

Mlọ ọgwụ

Meldonium (Mildronate®) bụ analog nke ahaziri adịchaghị nke carnitine gamma butyrobetaine (nke dị ugbua GBB), ebe ana - eji atomatik dochie otu hydrogen atọm. Enwere ike ịkọwa nsonaazụ ya na anụ ahụ n'ụzọ abụọ.

Mmetụta na njikọ carnitine

N'ihi mgbochi nke ọrụ butyrobetaine hydroxylase, meldonium na-ebelata biosynthesis nke carnitine ma si otú a na-egbochi mbupụ acids ọdụdụ ogologo site na mkpụrụ ndụ, na-egbochi mkpokọta nke mmanu abuba nke unoxidized fatty acids, acylcarnitine na acylcoenzyme nke ndị ahụ, na-ewepụta ngwa ngwa, N'okpuru ọnọdụ ischemia, Mildronate® na-eweghachi nguzozi n'etiti nnyefe oxygen na oriri na mkpụrụ ndụ, na - ewepụ nsogbu ntụgharị nke ATP, n'otu oge na - eme ka usoro ọzọ ike - glycolysis, nke a na - arụ na-enweghị ihe oriri oxygen ọzọ.

N’inwe ibu dị ukwuu n’ihi ike dị ukwuu n’ime mkpụrụ ndụ nke ahụ siri ike, mbelata na-adị nwa oge n’ime ọdịnaya nke ọdụdụ abụba. Nke a, n'aka nke ya, na-akpali metabolism nke ọdụdụ abụba, tumadi njikọ nke carnitine. A na-achịkwa biosynthesis nke carnitine site na ọkwa plasma na nrụgide ya, mana ọ bụghị ịdabere na ịta cursitine na-achọpụta ihe dị na sel. Ebe ọ bụ na meldonium na-egbochi ntụgharị nke GBB na carnitine, nke a na-eduga n'ịbelata ọkwa nke carnitine na ọbara, nke a na-eme ka njikọ nke carnitine dị larịị, ya bụ, GBB. Site na mbelata nke ịta meldonium, a na-eweghachi usoro carnitine biosynthesis ma tinyekwa ịta abụba na sel. Ya mere, mkpụrụ ndụ na-anata ọzụzụ mgbe niile, nke na-enye aka na nlanarị ha n'okpuru ọnọdụ nke ibu dị ukwuu, ebe a na-ebelata ọdịnaya nke abụba abụba mgbe niile, ma mgbe ebenyere ibu ahụ, a na-eweghachi ọdịnaya acid ngwa ngwa. N'ọnọdụ oke ibu, mkpụrụ ndụ 'ọzụzụ' site n'enyemaka nke ọgwụ Mildronate® na-adị ndụ n'ọnọdụ ndị ahụ mgbe mkpụrụ ndụ ndị “na-enyeghị ọzụzụ” nwụrụ.

Onye ogbugbo nke sistemụ GBB-ergic system

A kọwawo ya na n'ime ahụ nwere usoro akọwapụtabeghị nke mbufe nke mmetụta akwara - GBB-ergic system, nke na-ebugharị mgbasa nke mkpịsị akwara na mkpụrụ ndụ somatic. Onye ogbugbo nke usoro a bụ ihe na - ebute carnitine ozugbo - GBB ester. N'ihi esterase, nke a

onye ogbugbo ahụ na-enye onye electron n’ụlọ mkpọrọ, si otú a na-ebufe ihe ọkụ eletrik, ya onwe ya na-agbanwe gaa GBB.

Ntinye nke GBB ga - ekwe omume na mkpụrụ ndụ somatic ọ bụla nke ahụ. A na-achịkwa ihe na-agba ọsọ ya site na ike nke mkpali na ume ike, nke na-adabere na ntinye nke carnitine. Ya mere, na mbelata nke ịta carnitine, a na-akwalite njikọ nke GBB. Ya mere, n’ime anụ ahụ, enwere usoro mmeghachi omume akụ na ụba nke na-enye azịza zuru oke maka iwe ma ọ bụ nrụgide: ọ na-amalite na nnata nke mgbaàmà site na eriri akwara (n'ụdị elektronik), na-esote njikọ nke GBB na ester, nke, n'aka nke ya, na-eburu mgbaama ahụ. na mkpụrụ ndụ mematran. Mkpụrụ ndụ Somatic na mgbakasị ahụ mejupụtara ụmụ irighiri ihe ọhụrụ, na-enye mgbasa mgbaàmà. Mgbe nke a gasịrị, ụdị GBB nke hydroly na-ekere òkè na njem na-arụ ọrụ na-abanye umeji, akụrụ na ule, ebe ọ na-agbanwe gaa carnitine. Dịka anyị kwuru na mbụ, meldonium bụ analog nke ana - ahazi nke GBB, nke a na - eji nitrogen atọm dochie otu hydrogen atọm. Ebe ọ bụ na enwere ike ekpughere meldonium na GBB-esterase, ọ nwere ike ịrụ ọrụ dị ka "onye ogbugbo". Agbanyeghị, GBB-hydroxylase anaghị emetụta meldonium ma yabụ, mgbe etinye ya n’ime ahụ, ịta carnitine anaghị abawanye, kama ọ na-ebelata. N'ihi eziokwu ahụ bụ na meldonium n'onwe ya na-arụ ọrụ dị ka “onye ogbugbo” nke nrụgide, na-emekwa ka ọdịnaya nke GBD dịkwuo elu, ọ na-eme ka mmepe nke nzaghachi anụ ahụ. N'ihi nke a, ọrụ metabolic dị na sistemụ ndị ọzọ, dịka ọmụmaatụ, sistemụ akwara etiti (CNS), na-abawanye.

Ihe ngosi maka ojiji

- ọrịa angina pectoris na infịction myocardial (dịka akụkụ nke usoro ọgwụgwọ)

- adịghị ala ala obi (na usoro ọgwụgwọ)

- nnukwu ihe mberede ụbụrụ (na usoro ọgwụgwọ)

- hemophthalmus na ọnyá azụ dị iche iche etiologies, thrombosis nke akwara azụ na akwara ya, retinopathy nke etiologies dị iche iche (ọrịa shuga, ọbara mgbali elu)

- oke echiche na nke anụ ahụ, gụnyere n'etiti ndị egwuregwu

- wepu ọrịa na-egbu egbu na-egbu egbu (yana yana usoro ị forụ mmanya na - egbu egbu)

Usoro onunu ogwu na nhazi

Inye ndị okenye nọ n'ime.

Ọrịa obi

Dị ka akụkụ nke usoro ọgwụgwọ siri ike, 0.5-1.0 g kwa ụbọchị site na ọnụ, na-ewere ọgwụ ahụ dum otu oge ma ọ bụ kewaa ya na usoro 2. Ọgwụgwọ ya bụ izu isii na isii.

Cardialgia na ndabere nke cardiomyopathy - site na ọnụ, 0.25 g ugboro abụọ n'ụbọchị. Usoro ọgwụgwọ ya dị ụbọchị iri na abụọ.

Ihe ọghọm nke Cerebrovascular

A na - eji ọgwụ ọnụọgụ ọgwụ maka ọgwụ ọjọọ eme ihe maka ụbọchị iri, mgbe ahụ, ha gbanwere ịbanye ọgwụ ahụ site na 0-1-1.0 g kwa ụbọchị. Usoro ọgwụgwọ niile bụ izu isii na isii.

Ọrịa ụkwara ụbụrụ - 0,5 g ọnụ kwa ụbọchị. Usoro ọgwụgwọ niile bụ izu isii na isii. Nmeghachi ọgwụ ugboro ugboro (ọ na-abụkarị ugboro 2-3 kwa afọ) enwere ike mgbe ịgachara ndị dọkịta.

Hemophthalmus na ọnya azụ nke etiologies dị iche iche, thrombosis nke akwara azụ na akụkụ ya, retinopathy nke etiologies dị iche iche (ọrịa shuga, ọbara mgbali elu)

A na-eji ụdị usoro ọgwụ infinti eme ihe ruo ụbọchị iri, mgbe ahụ, ha na-agbanye na ị takingụ ọgwụ ahụ n'ime 0,5 g kwa ụbọchị, na-ewere ọgwụ ahụ dum otu oge ma ọ bụ kewaa ya abụọ. Usoro ya bụ ụbọchị 20.

Iju oke na nke anụ ahụ, gụnyere n'etiti ndị egwuregwu

Ndị okenye 0.25 g ọnụ 4 ugboro n'ụbọchị. Usoro ọgwụgwọ ya bụ ụbọchị 10-14. Ọ bụrụ na ọ dị mkpa, a na-emeghachi omume ahụ ka izu abụọ gachara.

Ndị na-eme egwuregwu 0,5-1.0 g nke ọnụ 2 ugboro n'ụbọchị tupu ọzụzụ. Oge izi ihe dị na nkwadebe bụ ụbọchị 14-21, n’oge asọmpi - ụbọchị 10-14.

Ọrịa ị withdrawalụ mmanya na-egbu egbu

N'ime, 0,5 g ugboro anọ n'ụbọchị. Ọgwụgwọ ya bụ ụbọchị 7-10.

Ihe ngbanwe

- Hypersensitivity na ihe nọ n'ọrụ ma ọ bụ ihe ọ bụla inyeaka nke ọgwụ

- ụba intracranial mgbali (mebiri nke venous outflow, intracranial etuto ahụ)

- afọ ime na lactation, n'ihi enweghị data gbasara ọgwụ na-eji ọgwụ eme ihe n'oge a

- ụmụaka na ndị na-eto eto nọ n’agbata afọ 18, n’ihi ụkọ data gbasara ọgwụ n’oge ọgwụ a.

Mkparịta ụka ọgwụ ọjọọ

Na-emeziwanye nsonaazụ nke ndị ọrụ akwara mmiri, ụfọdụ ọgwụ antihypertensive, cardiac glycosides.

Enwere ike ijikọ ya na ọgwụ antianginal, ọgwụ anticoagulants, ndị na-egbochi antiplatelet, ọgwụ antiarrhythmic, diuretics, bronchodilators.

N'iburu n'uche mmepe mmepe nke tachycardia na-erughị ala na mgbatị ọbara, a kwesịrị ịkpachara anya mgbe ejikọtara ya na ọgwụ ndị nwere otu mmetụta.

Ntụziaka pụrụ iche

Ekwesịrị iji nlezianya gosipụta na ndị ọrịa nwere ọrịa imeju na akụrụ na iji ọgwụ ogologo oge.

Mildronate® abụghị ọgwụ izizi maka ọrịa na-arịa nnukwu ọrịa coronary syndrome.

Akụkụ nke nsonaazụ nke ọgwụ nwere ike ịkwọ ụgbọala ma ọ bụ usoro ndị nwere ike ịdị ize ndụ

Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọala ma ọ bụ igwe nwere ike ịdị ize ndụ.

Dodoụbiga ya ókè

Amaghị ọgwụ ịdoụbiga ọgwụ ike Mildronate®, ọgwụ adịghị ala.

N'ihe banyere ịdoụbiga mmanya ókè, ọgwụgwọ Symptomatic.

Mpempe mwepụta

Capsules 250 mg. A na-etinye capsules 10 na paịlị pịrịgrị nke ihe nkiri polyvinyl chloride na polyvinylidene mkpuchi kloride na aluminom. Mkpokọta ngwongwo 4 dị na ntuziaka maka ojiji na steeti na asụsụ Russian na-etinye n'ime mkpọ kaadiboodu.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ ngwa ngwa, bioavailability bụ 78%. Oke ịta (C_max) A na - enweta plasma ọbara n'ime awa 1-2 ka abatala. Ọ bụ metabolized n'ime ahụ tumadi na imeju na ịmepụta nke isi metabolites abụọ nke akụrụ wepụta. Ọkara ndụ (T₁/₂) mgbe ejiri ọnụ kwuo ya, ọ dabere na dose ahụ, bụ awa 3-6.

Jiri n’oge ime na n’oge a na-enye nwa ara

A mụbeghị nchekwa nke ụmụ nwanyị dị ime, yabụ, iji zere mmerụ ahụ ụmụaka nwere ike ịmụrụ nwa, ọgwụ a dị n'ime ụmụ nwanyị dị ime.

Notcụ mmiri ara ehi na nsonaazụ ahụike nke nwa amụrụ ọhụrụ amụbeghị, yabụ, ọ bụrụ na ọ dị mkpa, ị ofụ ọgwụ ahụ ga-akwụsị ị breastụ ara.

Mmetụta akụkụ

A na-anabata Meldonium nke ọma. Agbanyeghị, na ndị ọrịa nwere oke mmerụ, yana n'ihe gbasara oke ịtụ aro ha, mmeghachi omume na-achọghị.
A na-ekekọta mmeghachi omume ọgwụ na-achọghị ka usoro ahụ dị ka usoro usoro ihe ndị a dị ugboro ugboro: ugboro ole (> 1/10), ọtụtụ mgbe (> 1/100 na 1/1000 na 1/10 000 na