Ọrụ nke glucophage na ọgwụgwọ pathogenetic nke ọrịa shuga 2

Bipụtara na akwụkwọ akụkọ:
Ọria Cancer Vol. 18, Nke 10, 2010

Ph.D. I.V. Kononenko, prọfesọ O.M. Smirnova
Statelọ Ọrụ Federal Steeti Endocrinological Research Center, Moscow

Elldị nke abụọ nke ọrịa shuga mellitus bụ ọrịa metabolic na-adịghị ala ala nke ejiri hyperglycemia na-adịgide adịgide mara, nke bụ nsonaazụ ntụpọ na azịza nke insulin. Nke a bụ ọrịa siri ike, na-adịghị ala ala ma na-aga n’ihu mgbe niile. A na-ekpebi nnabata na-adịghị mma na ndị ọrịa nwere ụdị ọrịa shuga 2 (ụdị shuga 2) site na mmepe nke nsogbu macro- na microvascular. Ihe na-ebute nsogbu ụbara akwara bụ ọnya akwara nke isi akwara mmiri, na-eduga na mmepe nke ọrịa obi na akwara na ọrịa, ọrịa ụbụrụ na imebi ọnya nke akwara dị ala. Ọrịa microvascular na-esite na mmebi nke microvasculature, nke akọwapụtara maka ọrịa shuga, na-ejikọ ọnụ nke okpukpo okpuru ala. Ihe ngosi nke ulo ogwu nke microangiopathy bu nephropathy diabetia na retinopathy. DM bụ ihe kachasị akpata ikpu ìsì na ndị okenye. Ebumnuche nke ọgwụgwọ ọrịa shuga bụ ime ka ọrịa glycemia kwụsịlata ma belata ihe egwu nke nnukwu nsogbu yana nnukwu nje. Ihe kachasị dị ize ndụ na-emetụta mmepe nke nsogbu obi na ọrịa na-arịa ọrịa shuga 2dị nke abụọ bụ steeti nke carbohydrate metabolism, ọbara mgbali na ụdị plasma ọbara. Tebụlụ nke 1 na-egosi ebumnuche ebumnuche nke ihe ndị bụ isi na-egosi, mmezu nke na-achi asuresụ arụmọrụ nke ndị ọrịa nwere ụdị shuga 2.

Tebụl 1. Nchịkwa nchịkwa (ebumnuche ọgwụgwọ) maka ụdị ọrịa shuga 2 (Algorithms maka nlekọta pụrụ iche maka ndị ọrịa nwere ọrịa mellitus, 2009)