Glucobay: ntuziaka maka ojiji

Ngwakọta na ụdị ntọhapụ. Mbadamba akwụkwọ ndị dị na Glucobai, mbadamba Glucobai 100. Ngwakọta ọrụ: acarbose. Onye na-ahụ maka ọgwụ antidiabetic. Ngwa dị irè (ụdị na nnukwu). Glucobai 50: 1 mbadamba nwere 50 mg nke acarbose. Mbido Glokobay 100: 1 nwere 100 mg nke acarbose. Ihe ndi ozo: microcrystalline cellulose, silicon dioxide chụgara nke ukwuu, magnesium stearate, stachi ọka.

Mbadamba: ngwugwu nwere mbadamba 126 nke 100 mg acarbose nke ọ bụla nwere kalenda. Otu mkpọ nwere 30 mbadamba 50 acarbose nke ọ bụla. Otu mkpọ nwere 30 mbadamba 100 acarbose nke ọ bụla.

• Omume ọgwụ
• Mlọ ọgwụ
• Ihe ngosi maka ojiji
• Ihe ngbanwe
• Nsonaazụ
• Mmekọrịta na ọgwụ ndị ọzọ

Omume ọgwụ. N'ime ụdị anụmanụ niile a na-amụ amụ, acarbose na-etinye nsonaazụ ya na eriri afọ. Ihe acarbose sitere na mgbochi nke enzymes eriri afọ (alfa-glucosidase) tinyere nsị nke di-, oligo- na polysaccharides. Dabere na dose ahụ, nke a na-eduga n'ibelata mgbari nke carbohydrates ndị a. N’ihi nke a, a na-eme ka glucose na nwayọ nwayọ pụọ na carbohydrates ma were nwayọ nwayọ n’ọbara. Ya mere, acarbose na-ebelata ịrị elu nke shuga ọbara mgbe ị risịrị nri. N'ihi mmetụta ha nhatanha na nnabata shuga site na eriri afọ, a na-agbadata usoro shuga dị n'ọbara ụbọchị ma belata nkezi shuga ọbara.

Ngwongwo Toxicological. Ọrịa ọjọọ A na-eme nnyocha banyere oke nsi mgbe a na-etinye ọnụ na nchịkwa nke acarbose na ụmụ oke, oke bekee na nkịta. Nsonaazụ nnwale nke oke egbu ka egosiri na okpokoro a. Dabere na data ndị dị n'elu, acarbose mgbe otu nchịkwa ọnụ kwesịrị ka ewere ya na ọ bụghị ọgwụ na-egbu egbu, ruo usoro nke 10g / kg 50 ọ ga-ekwe omume iru. Na mgbakwunye, enweghị akara nsi ọ bụla hụrụ na ụdị anụmanụ anụmanụ amụrụ n'ime usoro nyocha. Mgbe usoro ọgwụgwọ intraven, ọgwụ ahụ bụkwa ọgwụ anaghị egbu egbu.

Subchronic nsi. Emere ọmụmụ nnabata maka ọnwa 3 na oke na nkịta. Agụrụ Acarbose na oke iji ntụtụ nke 50-450 mg / kg ọnụ. Tụnyere ndị otu na-ahụ maka njikwa, nke na-anataghị acarbose, ọgwụ mgbochi niile na usoro ọgwụgwọ-kemikal agbanweghị. Nnyocha ndị na-esote akụkọ ihe mere emeghịkwa gosipụta ihe mebiri emebi na usoro ọgwụgwọ niile. A mụkwara ọgwụ ọnụọgụ 50-450 mg / kg na nkịta. Tụnyere ndị otu na-achịkwa anabataghị acarbose, mgbanwe nke ike nke anụ ahụ na-agbanwe, ọrụ serum alpha-amylase na ntinye urea ọbara kpebiri site na ihe nyocha ahụ. Na otu dị iche iche na-anata usoro onyonyo dị iche iche, enwere mmetụta na nhazigharị nke anụ ahụ, nke egosiri na eziokwu ahụ bụ na na-eri nri kwa ụbọchị 350 g kwa ụbọchị, nkezi nke otu ndị ahụ n’ime izu anọ mbụ nke nnwale ahụ belatara nke ukwuu.

Mgbe ha mụsịrị ọnụ ọgụgụ ihe oriri ka 500 g kwa ụbọchị na izu nke ise nke nnwale ahụ, oke anụmanụ anọrọ na otu ọkwa. Mgbanwe ndị a na oke ibu, nke a na-ebute site na iji usoro ọgwụgwọ elu, bụ ngosipụta nke ọgwụ ọgwụ nke ihe nnwale ahụ, na-eme ka ọ pụta n'ihi mmebi nke nri na-akpata isocaloric (ọnwụ nke carbohydrates), ha abụghị mmetụta na-egbu egbu. Ihe butere ọgwụgwọ na-apụtachaghị ìhè, ya bụ ọnọdụ catabolic nke metabolism, na-amalite site n'ibu oke, ekwesịrị ịtụle ntakịrị ịrị elu na urea. Mbelata ọrụ alfa-amylase ekwesiri ileba anya dika ihe ama ama nke uto ọgwụ di elu.

Ọrịa egbu egbu Emere nnwale na-adịghị ala ala na oke oke, nkịta na anụ, ma ogologo oge eji nkịta bụ ọnwa iri na abụọ, n'ọbọ ọnwa iri abụọ na anọ yana ọnwa iri isii. Na nnwale na oke, na mgbakwunye na mbibi a na-esite na iji nke na-adịghị ala ala, ekwesịrị ịkọpụta nsonaazụ o kwere omume.

Carcinogenicity. Enwere otutu ihe omumu nke carcinogenicity. a) Mkpịpịkịkị nke Sprague-Dowley nwetara n'ime ọnwa iri abụọ na anọ - iri abụọ na isii iri nri nke ruru 4500 μg nke acarbose. Inye acarbose na nri nwere ụkọ nri. N'okpuru ọnọdụ nke nnwale a, ma e jiri ya tụnyere njikwa, akụrụ parenchyma (adenoma, hypernephroid carcinoma) dabere na ọnụego ahụ, ebe a na-ebelata pasent dum nke etuto ahụ (karịsịa akpịrị homonụ). Iji wepu nri na-edozi ahụ, n'ọmụmụ na-esote, ụmụ anụmanụ natara nnọchi glucose. N ’usoro nke acarbose 4500 mcg na glucose nnọchi, ahụ dị 10% dị ala karịa n’etiti ndị na-ahụ maka nchịkwa, ahụghị ọnụ ọgụgụ akwara nke akụrụ.

Na nkwupụta nke nnwale ahụ na-enweghị nnọchi glucose, nke were ọnwa 26, mmụba ndị ọzọ na ọnụ ọgụgụ mkpụrụ ndụ ibu nke testes Leydig. N’ime ndị niile nwere nnọchi glucose, ndị na-egosi glucose n’otu n’otu mụbaa ịmụba amụba (alimentary diabetes with a doses glucose). Site na ntinye nke acarbose site na iji eriri afọ, ibu nke anụ ahụ na ọkwa nchịkwa, mmụba ọgwụ na-arụ ọrụ na ụdị nnwale a anaghị agụpụ. Ọnụ ọgụgụ nke etuto ahụ bụ nke ọma.

b) Rist Wistar nwetara 0 - 4500 μg nke acarbose site na nri ma ọ bụ site na eriri afọ iri atọ. Acnye acarbose nri anaghị eme ka ị ghara ibu ibu. Site na 500 mcg nke acarbose, a na-abawanye cecum. A na-ebelata ọnụ ọgụgụ nke etuto ahụ, enweghị ihe ngosipụta nke ịrị elu na ọnụ ọgụgụ etuto ahụ.

c) Hamsters natara 0-4000 μg nke acarbose na-enweghị mgbanye glucose n'ime izu 60. Nime anụmanụ nwere oke onunu ogwu, ihe nmuta obara guliri elu bu ihe kwesiri ihe kwesiri ekwesi. Ọnụ ọgụgụ nke etuto ahụ adịghị aba ụba.

Nsi mmụpụta. Eduzi Teratogenicity na oke na oke bekee. N'ime ụdị anụmanụ abụọ a, a nwale iji ọgwụ 0, 30, 120, na 460 mg / kg. Na oke, a na-ahụ usoro onunu ogwu site na ụbọchị isii ruo ụbọchị iri na ise, na oke bekee site na ụbọchị isii ruo ụbọchị iri na asatọ. N'ime ụdị anụmanụ abụọ ahụ, ọ nweghị data enwetara maka mmetụta teratogenic nke acarbose n'ime usoro nke anwale. Achọpụtaghị nsogbu ọmụmụ amụba na oke oke nke nne na oke ruru oke 540 mg / kg kwa ụbọchị. Ojiji nke onunu ruru ihe ruru 540 mg / kg kwa ụbọchị n’oge mmepe nwa ebu n’afọ na ịrara nwa anaghị enwe oke na ụmụ aka ahụ. Onweghi data banyere ihe eji eme n’oge ime na n’oge a na-enye nwa ara.

Igha imekorita. Ọtụtụ ọmụmụ na mutagenicity adịghị egosi mmetụta genotoxic nke acarbose.

Mlọ ọgwụ Agụrụ Glucobay pharmacokinetics na probands mgbe nchịkwa ọnụ nke ihe akpọrọ (200 mg). Ebe ọ bụ na a na-ahapụrụ nkezi nke 35% nke redioaktivu (ego nke ihe inhibitory ma ọ bụ nke ngwaahịa na-ere ere na-emebi emebi) n'ime awa 96, enwere ike icheta pasent nke ọrụ a na-etinye na ya dịkarịa ala maka oke ndị a. Ihe puru iche mmamịrị nke ihe inhibitory ihe dị 1.7% nke ọgwụ enyere. Achọpụtara 51% nke ọrụ n'ime awa iri isii na asaa na feces. Mgbali ume nke mkpokọta igha ikuku na plasma nwere ugwu abụọ. Nke izizi kachasị na mkpokọta acarbose dịkarịrị 52,2 +15.7 μg / L mgbe awa 1.1 + 0.3 na-agakọ na ike nke ịta ihe nke nwere mmetụta mgbochi (49.5 + 26,9 μg / L mgbe afọ 2 gasịrị). Awa 2.1 + 1,6).

Nkezi kachasị nke abụọ 586.3 + 282.7 mcg / L ma erute na mgbe elekere 20.7 + 5.2. N'adịghị ka redioaktivu n'ozuzu, oke kachasị nke ihe inhibitory ihe na plasma bụ nkeji iri na 15-20 pere mpe. Nke abụọ, nke kachasị elu, kachasị karịa awa iri na anọ ruo iri abụọ na anọ ruo iri anọ na anọ ruo n’awa iri atọ na asaa, o yikarịrị ka resorption nke ngwaahịa nke ọrịa nje na-emetụta akụkụ ndị miri emi nke eriri afọ. Ọkara ọkara nke ihe inhibitory sitere na plasma bụ awa 3.7 + 2.7 maka nkesa ekesa na awa 9.6 + 4.4 maka oge ezumike. Dika ihe di omimi banyere ihe nlebara anya nke plasma, enwere ike ịgbako olu nke 0.39 l / n'arọ ibu maka proband.

Bioavailability. Bioavailability bụ 1 - 2%. Akụkụ a dị ala, sistemụ nwere usoro nke ihe inhibitory bụ ihe a na-achọsi ike ọ nweghị ihe ọ bụla maka ọgwụgwọ ọgwụgwọ.

Usoro usoro onunu ogwu. N'okwu nke ọ bụla, dibia a na-eleta ga-ahọrọ onunu ogwu ahụ, ebe ọ bụ na ịdị irè na ịnabata ihe dị iche iche. Ọ gwụla ma enyere gị aka, ejiri ọgwụ ndị a: Na mbido mbụ: mbadamba 3 x 1 nke 50 mg nke acarbose kwa ụbọchị ma ọ bụ mbadamba ụrọ 100 x nke acarbose kwa ụtụ, mgbe ahụ: 3 x 2 mbadamba 50 nke acarbose kwa ụbọchị ma ọ bụ 3 x 1 mbadamba ụrọ nke 100 mg nke acarbose kwa ụbọchị: ruo: 3 x 2 mbadamba nkume 100 mg nke acarbose kwa ụbọchị. Ọgwụ nwere ike ịrị elu site n’etiti 1 ruo izu abụọ, ma ọ bụrụ na ọ dị mkpa, na n’oge usoro ọgwụgwọ na-esote. Ọ bụrụ na, na-agbasochi anya na nri ahụ, mkpesa bilitere, a naghị atụ aro ka ị nwekwuo ọgwụ ahụ, ma ọ bụrụ na ọ dị mkpa, belata ya ntakịrị. Nkezi onwa bụ 300 mg nke acarbose kwa ụbọchị (karị 3 mbadamba mbadamba abụọ nke Glucobaya 50 kwa ụbọchị ma ọ bụ mbadamba 3 ugboro nke Glucobaya 100 kwa ụbọchị).

Mbadamba ogwu Glucobaya na-arụ ọrụ nke ọma naanị ma ọ bụrụ na ewere ya na obere ntakịrị mmiri mmiri ozugbo tupu nri. Oge itinye akwụkwọ nke Glucobay abụghị naanị.

Contraindications mgbe ị na-eji glucobai. Ntinye aka na acarbose na (ma obu) ihe ndi ozo. Ebe ọ bụ na data ezughị ezu na nsonaazụ na nnagide ụmụaka na ụmụaka, ekwesighi iji Glucobai mee ihe maka ndị ọrịa na-erubeghị afọ 18. Ọrịa afọ na-adịghị ala ala nke na-enwe nsogbu nri nri na nri. Ọnọdụ nwere ike ịka njọ n'ihi mmụba gas na eriri afọ (dịka ọmụmaatụ, ọrịa Remkheld, nnukwu hernias, warara na ọnya afọ). N'ime afọ ime, ekwesighi iji Glucobai, ebe ọ bụ na enweghi ahụmịhe na ụmụ nwanyị dị ime. Mgbe o nyechara acarbose akpọrọ, ntakịrị ihe redioaktivu na-apụta na rats rats na mmiri ara ehi. Maka ndị mmadụ, data dị mkpa adịbeghị. Ebe obu na achobose na mmiri ara ara eme ka ogwu a ka apughi, ewepuru ya maka ebum n’uche ịghara idebe glucobai n’oge inye nwa ara.

Nsonaazụ. Ọtụtụ mgbe, mkpọma na olu eriri afọ, mgbe ụfọdụ afọ ọsịsa na mgbu afọ. Ọ bụrụ na egoghị ọgwụ a kara aka maka ndị na-arịa ọrịa shuga, mmetụta ndị ọzọ si na eriri afọ na-agbakwu. Ọ bụrụ na, n’usoro idebe usoro nri edepụtara, nnukwu nsogbu na-ebilite, site na nkwekọrịta ya na dọkịta, a ga-eweghachi ọgwụ ahụ nwa oge ma ọ bụ ogologo oge. N'ọnọdụ ụfọdụ, megide ndabere nke iji Glucobay, ihe asymptomatic (na-enweghị mkpesa) na-ebili na enzymes imeju (mmụba na transaminases), na-apụ kpamkpam mgbe akagbuo ọgwụgwọ glucobai.

Mmekọrịta na ọgwụ ndị ọzọ. Mkpụrụ nri (shuga shuga) na ngwaahịa nri nwere shuga nri, n'ihi ịba ụba nke carbohydrates na nnukwu eriri afọ n'oge ọgwụgwọ glucobai, nwere ike ibute nsogbu nke eriri afọ na ọbụna afọ ọsịsa. Glucobai nwere mmetụta antihyperglycemic ma ọ dịghị akpata hypoglycemia. Ọ bụrụ na etinyere Glucobay na mgbakwunye na sulfonylurea na nhazi proformin ma ọ bụ insulin, mgbe ahụ, na mbelata ọbara shuga ruo n'ókè hypoglycemic, a ga-belata ọnụego nke sulfonylurea na metformin ma ọ bụ insulin. Ọ bụrụ na hypoglycemia dị ukwuu na-apụta, ekwesịrị iburu n'uche na n'oge ọgwụgwọ ya na Glucobaem, shuga na -eme nri na-agbadata nwayọ karịa fructose na glucose, yabụ adabaghị maka iwepụ hypoglycemia ngwa ngwa. N'ihi ya, a ga-eji shuga mkpụrụ vaịn mee ihe kama ị sugarụ shuga (okpete). N'ihe banyere ekwe omume nke acarbose, ekwesighi iji ọgwụ antacids, cholestyramine, adsorbents nke ime na enzyme iji melite mgbaze.

Cakpachara anya Anaghị anọ.

Isi okwu nke incompatibility. Amabeghị.

Dodoụbiga ya ókè. N'ihi ịdoụbiga mmanya ókè nke ihe metụtara Glucobay, yana ihe ọ drinksụ drinksụ na (ma ọ bụ) nri nwere carbohydrates (poly-, oligo-, disaccharides), flatulence, bloating na afọ ọsịsa nwere ike ime. N'okwu ahụ mgbe a na-ewere Glucobai na ị anyụbiga mmanya ókè na -eghara ị takingụ nri ọ bụla, mgbaàmà ịba ụba ekwesịghị ime. Maka ị doụbiga mmanya ókè, should ga-ajụ ị drinksụ ihe ọ dishesụ andụ na efere nwere carbohydrates (poly-, oligo-, disaccharides) na awa nke 4-6 na-esote.

Directionszọ ndị ọzọ. Nnọọ nnabata oke nri maka ndị ọrịa nwere ọrịa shuga, n'ezie, ọ dịkwa mkpa na ọgwụgwọ glucobaemia. Can nweghị ike igbochi oriri Glucobay mgbe niile na enweghị ndụmọdụ dọkịta, ebe ọ bụ na shuga ọbara nwere ike ibili. N'ime ndị ọrịa a na-agwọ naanị nri, Glucobai anaghị ebute hypoglycemia. Ọ bụrụ na n'oge ọgwụgwọ Glucobaem n'ihi ntakịrị ume nke insulin na ndị ọrịa na-anata ọgwụgwọ na sulfonylurea ma ọ bụ metformin, hypoglycemia na-adị, grape grape (ọ bụghị nri, okpete, shuga). Ekwesịrị itinye ọgwụgwọ Glucobai na akwụkwọ nke onye ọrịa nwere ọrịa shuga.

Ndụ shelf. N’ime ngwugwu mbụ, echekwara mbadamba nkume ndị ahụ afọ 4.

Ọnọdụ nchekwa. Mgbe okpomọkụ dị karịa 25 Celsius C na iru mmiri dị n'ime ụlọ ahụ dị karịa 75 H, mbadamba ndị ewepụrụ na nkwakọ ngwaahịa ahụ nwere ike ree. Ya mere, ekwesịrị ịwepụ mbadamba ihe nkiri ahụ ozugbo ejiri ya.

Ezumike ọgwụ. Dika dọkịta nyere ya. Ọgwụ a nwere ihe mmetụta ya na sayensị sayensị amabeghị nke ọma. Ya mere, onye na-azụ ahịa ọgwụ ga-edo onwe ya n'okpuru ikike gọọmenti etiti ruru eru mkpesa na ahụmịhe nke iji ọgwụ a dabere na edemede nke 549, Paragraf nke 6 nke Iwu na Ngwọta.

Emeputa Bayer AG 5090 Leverkusen-Bayerwerk

Ojiji nke glucobai ọgwụ naanị dị ka dọkịta nyere, a na-enye ntuziaka ahụ maka ntụnye!

Njirimara physicochemical nke dị mkpa

Mpempe akwụkwọ ọcha ma ọ bụ nke na-acha odo odo n'otu akụkụ nke mbadamba 50 mg nke gbara ọsọ na "G 50", mbadamba 100 mg - "G 100" na ọkwa, n'akụkụ nke ọzọ mbadamba 100 mg - ala mmụọ, mbadamba 50 mg - akara na ụdị nke obe obe. ,

Otu mbadamba 1 nwere acarbose 50 mg ma ọ bụ 100 mg

ndị na-ebu ụzọ: aerosil (silloon silicon dioxide), magnesium stearate, ọka ọka, microcrystalline cellulose.

Ngwongwo ogwu

Ọgwụ ọgwụ. Ngwakọta ọrụ na-arụ ọrụ n'ime ọgwụ ahụ, acarbose, bụ pseudotetrasaccharide nke microbial sitere. Acarbose na-arụ ọrụ na ọkwa nke eriri afọ, na-egbochi ọrụ nke obere enzymes eriri afọ (alpha-glucosidases), bụ ndị na-etinye aka na nbibi nke di-, oligo- na polysaccharides. N'ihi ya, enwere oge na-egbu oge na nnweta nke carbohydrates, na-esote ntọhapụ na-egbu oge na nnabata nke glucose, bụ nke etolite n'oge nbibi nke carbohydrates. Ya mere, acarbose na-egbu oge ma na-ebelata mmụba postprandial n'ọbara glucose ọbara. N'ihi nnabata glucose ziri ezi site na eriri afọ, a na-ebelata ogo ị na-aghọrọ ya kwa ụbọchị. N'ihe banyere mmụba nke usoro haemologlobin glycosylated, acarbose na-ebelata ọkwa ya.

Egwu. Ihe dị ka 35% nke nchịkwa a na-agbaso n'ụdị metabolites, erughị 2% n'ụdị arụmọrụ. Ọ bụ metabolized na nri diges, tumadi site na nje eriri afọ ma akụkụ ya site na nri diges na enwupụta opekempe 13 ogige n'ụdị sulfate, methyl na glucuronic conjugates. Mgbe ị theụ ọgwụ ahụ, e nwere ọnụ ọnụ abụọ na mkpokọta acarbose na plasma ọbara, ngụkọta oge 52.2 ± 15.7 μg / L mgbe 1.1 ± 0.3 h na 586.3 ± 282.7 μg / L mgbe 20 7 ± 5,2 awa, n'otu n'otu. A kwenyere na ọdịdị nke elu nke abụọ bụ n'ihi nnabata ngwaahịa ire ere site na akụkụ miri emi nke obere eriri afọ.

Nkesa. Olu nke nkesa bụ 0.32 l / n'arọ ahụ.

Bioavailability. Bioavailability bụ naanị 1-2%. Percentagedị dị ala dị sistemụ dị na sistemụ arụmọrụ a chọrọ ka ọ bụrụ na acarbose na-arụ ọrụ n'ime obere eriri afọ. N'agbanyeghi nke a, obere bioavailability adịghị emetụta ọgwụgwọ nke ọgwụ.

Mmechi Ndụ ọkara maka nkesa na ntụgharị ihu bụ awa 3.7 ± 2.7 na awa 9.6 ± 4.4, na nso nso, 51% nke ihe na-arụ ọrụ ka ewepụrụ site na eriri afọ, 1.7% adịghị agbanwe agbanwe yana dịka metabolite na-arụ ọrụ, yana 34% n'ụdị metabolites - site na akụrụ.

Ngwakọta ọgwụ maka ọrịa shuga yana nri.

Mgbochi nke ụdị ọrịa shuga nke II n'ụba n'ime ndị ọrịa nwere nnabata glucose anwụrụ (PTH *) yana nri na mmega ahụ.

Usoro onunu ogwu na nhazi

Etubere oke kachasị mma n’otu n’otu maka onye ọrịa ọ bụla, ebe ọ bụ na ịdị irè na nnabata ọgwụ a nwere ike ịdị iche.

A na-ewere mbadamba na-enweghị ata ata, na obere mmiri mmiri, ozugbo nri ma ọ bụ were ya na nri mbụ.

Ogologo oge ọgwụgwọ agaghị ejedebe.

Ngwakọta ọgwụ maka ọrịa shuga yana nri.

Usoro izizi bụ 1 mbadamba 50 mg 3 ugboro n'ụbọchị ma ọ bụ mbadamba 100 mg 3 ugboro n'ụbọchị. Mgbe ahụ, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ gaa na 100 mg ugboro 3 kwa ụbọchị (mbadamba abụọ nke 50 mg ugboro atọ n'ụbọchị ma ọ bụ mbadamba 100 nke 100 mg ugboro 3 kwa ụbọchị).

N'ọnọdụ ụfọdụ, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ọgwụ nke ọgwụ ahụ ruo 200 mg ugboro atọ n'ụbọchị.

Ọ na-atụ aro ka iwelie dose nke ọgwụ mgbe izu 4-8 ma ọ bụrụ na enwetaghị nsonaazụ ahụike dị mkpa n’ebe ndị ọrịa nọ n ’ụzọ gara aga. Ọ bụrụ na onye ọrịa nwere mkpesa nke ịdị mma, n'agbanyeghị ịgbasochi nri anya, mgbe ahụ, a ga-akwụsịkwu mmụba nke ọgwụ ahụ, ọ bụrụ na ọ dị mkpa, ọbụlagodi belata. Ọkara kwa ụbọchị nke Glucobai ® bụ 300 mg nke acarbose kwa ụbọchị.

Mgbochi ụdị mellitus nke ọrịa shuga nke II na ndị ọrịa nwere nnabata glucose na-emetụta ya na nri na mmega ahụ.

Usoro akwadoro maka ịgwọ ụdị ọrịa shuga II na ndị ọrịa nwere ndidi glucose 100 mg ugboro atọ kwa ụbọchị.

Ọgwụ mbụ bụ 50 mg otu ugboro n'ụbọchị (1 mbadamba 50 mg ma ọ bụ ½ mbadamba 100 mg otu ugboro n'ụbọchị). N'ime ọnwa 3, a na-abawanye ọgwụ ahụ ruo 100 mg ugboro atọ n'ụbọchị (mbadamba 2 nke 50 mg ugboro atọ n'ụbọchị ma ọ bụ 1 mbadamba 100 mg 3 ugboro kwa ụbọchị).

Ọrịa ndị okenye (karia 65): a chọghị ndozi ọgwụ.

Ndị ọrịa nwere oke ịba ọcha n'anya adịghị achọ nhazi mmezi.

Ihe ngbanwe

• Hypersensitivity na acarbose na / ma ọ bụ ndị ochie.
• Ọrịa afọ na-ekweghị ala ala nke nwere nnukwu nri nri na mgbakasị ahụ ike.
• Ọnọdụ tinyere flatulence (ọrịa Remkheld, nnukwu hernias, stenosis na ọnya afọ).
• Okpu akuko gbasara akwara obi (nwebi ihe gbasara creatinine)

Dodoụbiga ya ókè

Ọ bụrụ na a na-eji Glucobay a kwa oke ihe ọ simụ drinksụ n'otu oge yana ihe ọ andụ andụ na / ma ọ bụ ngwaahịa nri nwere carbohydrates (poly-oligo- ma ọ bụ disaccharides), ịdoụbiga mmanya ókè na afọ ọsịsa nwere ike ibute ya.

N'ihe banyere oke ịdoụbiga mmanya ókè, a na-atụ aro ka ewepụrụ ihe ọ drinksụ andụ na efere nwere carbohydrates na nri ahụ maka awa 4-6.

N'ihe banyere mbadamba ọgwụ oke ị ,ụ ọgwụ, ọ nweghị mmepe mgbaàmà nke eriri afọ na-atụ anya na mpụga nri.

Njirimara ngwa

A na-atụ aro ka a na-enyocha ọkwa nke enzymes “imeju” ọnwa 6-12 mbụ nke ọgwụgwọ, ebe ọ bụ na mgbe ị na-a usingụ ọgwụ ahụ, mmụba asymptomatic na ọkwa nke "imeju" enwere ike. Dịka iwu, mgbe ha kwụsịrị ọgwụ ahụ, ọrụ ha na-abụkarị ọgwụ nkịtị.

E guzobeghị ịdị irè na nchekwa acarbose na ndị ọrịa na-erubeghị afọ 18.

Ọ bụrụ na ekwenyeghị na nri dọkịta nyere ya, ogwugwo si na eriri afọ nwere ike ịka njọ. Ọ bụrụ na mgbaama ahụ kawanyere njọ, na-agbanyeghị etu esi edobe nri, ọ dị mkpa ịkpọtụrụ dọkịta ma belata ọgwụ ahụ maka obere oge ma ọ bụ ogologo oge.

Megide usoro ọgwụgwọ Glucobai ®, ojiji nke sucrose (nri shuga) na ngwaahịa nwere ya nwere ike ibute mgbatị afọ na afọ ọsịsa n'ihi ịba ụba nke carbohydrates na eriri afọ.

Glucobai ® gosipụtara mmetụta hypoglycemic, mana ọ naghị ebute hypoglycemia na ndị ọrịa.

N'oge ị theụ ọgwụ Glucobai ® sucrose (shuga nri) na-agbadata nwayọ nwayọ na fructose na glucose, yabụ adabaghị maka ọgwụgwọ ngwa ngwa nke hypoglycemia ngwa ngwa. N'okwu a, glucose kwesịrị iji.

Ime na lactation

Ebe ọ bụ na enweghị data banyere iji Glucobay drug ọgwụ ahụ n'oge afọ ime, ọ naghị atụ aro ịhọpụta ya ndị inyom dị ime.

Mgbe ewebata achobose isotope nke radiobeled nye oke bekee mgbe a na-enye ya ara, a hụrụ obere redioaktivu na mmiri ara. Enweghị data dị mkpa na mmadụ. Agbanyeghị, ebe ọ bụ na mmetụta ọgwụ ndị emepụtara ụmụ amụrụ ọhụrụ n'ihi ọnụnọ acarbose na mmiri ara ara, anaghị etinye ya n'ọrụ, ọ naghị atụ aro ka etinyere Glucobai ® n'oge a na-enye ya ara.

Mmetụta ikike ịnya ụgbọ ala na igwe.

Enweghị data na mmetụta ọ bụla na ikike ịkwọ ụgbọala na igwe.

Mmekọrịta na ọgwụ ndị ọzọ

Ọ bụrụ na edepụtara Glucobai ® yana insulin ma ọ bụ nkwadebe nwere sulfonylureas ma ọ bụ metformin, ọkwa glucose ọbara nwere ike ịdalata na hypoglycemic range (n'ọnọdụ ndị dịkarịsịrị, hypoglycemic coma nwere ike ịmalite), nke chọrọ mbelata usoro ha.

N'ọnọdụ ndị na-adịghị ahụkebe, acarbose nwere ike imetụta bioav adị nke digoxin, nke gụnyere mkpa ịhazigharị akụkụ nke ikpeazụ.

A naghị atụ aro ka ikpokọta Glucobai ® na cholestyramine, sorbents na nsị enzyme n'ihi nsonaazụ ha nwere ike na ịdị adị nke acarbose.

Onweghi ọgwụ emekorita ya na dimethicone / simethicone.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu - mbadamba mkpuchi nwere:

• 50 mg: okirikiri, biconvex, na-acha ọcha ma ọ bụ na-acha odo odo na agba, ya na ihe osise nwere “G50” n'otu akụkụ yana akara ụlọ ọrụ (Bayer cross) nke ọzọ,
• 100 mg: oblong, biconvex, na-acha ọcha ma ọ bụ na-acha ọcha-acha odo na agba, ya na notch n'akụkụ ya abụọ, na-ese ihe onyonyo "G100" n'otu akụkụ.

Mbadamba ụrọ n’otu iberibe 15. n'ime blisters, a na-etinye blisters 2 ma ọ bụ 8 na igbe kaadiboodu.

Ihe eji arụ ọrụ: acarbose, na mbadamba 1 - 50 ma ọ bụ 100 mg.

Ihe inyeaka: anhydrous colloidal silicon dioxide, ọka ọka, magnesium stearate, microcrystalline cellulose.

Ogwu ogwu nke Glucobay

Glucobai bụ ihe nnọchianya hypoglycemic maka ojiji ọnụ. Akụkụ ike nke ọgwụ ahụ bụ acarbose. Ihe a na - eme ka ọkwa glucose dị n’ọbara jụọ oyi.

Kedu ka ọgwụ si arụ ọrụ? Acarbose bụ ihe na - egbochi mgbochi alpha glucosidase. Akụrụngwa na-arụ ọrụ nke ọgwụ ahụ na-ebelata ntụgharị enzymatic nke disaccharides, oligosaccharides na polysaccharides na monosaccharides. N'ihi nke a, a na-ebelata ọnụego nnabata nke glucose site na eriri afọ.

Ọ bụ ihe kwesịrị ịrịba ama na iji mbadamba ụrọ, hypoglycemia siri ike anaghị eto. Theụ ọgwụ ahụ mgbe niile na-ebelata ihe ize ndụ nke mmepe:

1. Myocardial infarction.
2. Mwakpo nke hypoglycemia na hyperglycemia.
3. Mmepe nke ọrịa na-adịghị ala ala nke usoro obi.

A na-ahụta nsonaazụ kachasị n'ihe dị n'ime ọbara mgbe awa 1-2 gachara. A na-ewepụta metabolites na-adịghị arụ ọrụ site na eriri afọ, akụrụ na umeji.

Ntuziaka maka iji ọgwụ ahụ

Mgbe ị na-ahọpụta Glucobai, a ga-amụ ntuziaka maka ojiji a ga-eji ya eme ihe, n'ihi na o nwere ozi na ihe niile na-egosi, contraindications na nsonaazụ ya. Kedu ọnọdụ ọ ga - adị mma ị takeụ ọgwụ a?

Ntuziaka ahụ kwuru na ekwesịrị iji ọgwụ ahụ mee ihe na usoro ọgwụgwọ siri ike nke ụdị shuga 1. Ihe ozo gosiputara iji aru bu oria oria abuo. Nwere ike iji ọgwụ maka oke ibu na ọrịa shuga.

Ma ifelata site na enyemaka nke Glucobay ga - ekwe omume naanị ma ọ bụrụ na ị soro usoro nri pụrụ iche. Ọ dị mma ịmara na onye na-efe efe ga-eri ma ọ dịkarịa ala kilogram 1000 kwa ụbọchị. Ma ọ bụghị ya, hypoglycemia siri ike nwere ike ịmalite, ruo na mpekere hypoglycemic.

Etu esi ewere ogwu a? Na-a pụ ọgwụ tupu nri. Ọgwụ nke mbụ bụ 150 mg. Kewaa ubochi ubochi ato n’ime ogwu ato. Ọ bụrụ na ọ dị mkpa, a na-eme ka usoro ahụ gaa 600 mg. Ma na nke a, a ga-ekewa ọgwụ kwa ụbọchị ka ọ bụrụ usoro 3-4.

Ọ bụrụ na n'oge usoro ọgwụgwọ onye ọrịa nwere flatulence na afọ ọsịsa, mgbe ahụ, usoro ọgwụgwọ ahụ kwesịrị ibelata, ma ọ bụ kwụsị ọgwụgwọ ahụ kpamkpam. A họrọ oge ịgwọ ọrịa na Glucobaem n'otu n'otu.

Ihe ndi n’echeghari anyi n’echekwa mbadamba:

• Ihe nfụkasị ahụ na akụkụ nke ọgwụ ahụ.
• Afọ ụmụaka. Edeghị ọgwụ a maka ndị ọrịa na-erubeghị afọ 18.
• Ọnụnọ nke ọnya afọ ma ọ bụ nke na-adịghị ala ala. Nyocha ndị dọkịta na-egosi na ọgwụ dị ize ndụ nye ndị mmadụ na-arịa ọrịa eriri afọ.
• Ọrịa mamịrị ketoacidosis.
• Imebi imeju. Amachibidoro ya ị useụ ọgwụ ma ọ bụrụ na mmadụ na-arịa ọrịa imeju, ọria ma ọ bụ ịba ọcha n'anya.
• Ahụ ọnya afọ nke eriri afọ ma ọ bụ akụkụ ndị ọzọ nke eriri afọ.
• Oge ime.
• Oge lactation. Mana ntuziaka a kwuru na enwere ike inye ndị nwanyị na-actụ ọgwụ ọgwụ ọgwụ ka ọ ga-abụ nkwụsịtụ nwa oge inye ya ara.
• Okpu mmebi ahuhu (ya na ihe omuma nke kariri 2 ml na 1 dl).
• Remgeld's syndrome.
• Ọnụnọ nke hernias buru ibu na mgbidi nke eriri afọ.
• Ọrịa ọrịa Malabsorption ma ọ bụ nsogbu.

N'iji nlezianya, a na-enye ndị mmadụ ọgwụ a mgbe hawachara ahụ. Ọzọkwa, imeghari usoro ọgwụgwọ ọ ga-adị mkpa ma ọ bụrụ na mmadụ nwere ọrịa na-efe efe ma ọ bụ ahụ ọkụ. Ọ dị mma ịmara na n'oge ọgwụgwọ, a gaghị enwe ike iri nri ndị nwere nnukwu ihe oriri. Ma ọ bụghị ya, ọrịa dyspeptik nwere ike ịmalite.

Kedu ka Glucobai si emekọrịta na ọgwụ ndị ọzọ? Achọpụtara na ọgwụ ahụ adịchaghị arụ ọrụ ma ọ bụrụ na a na-ewere ya akụkụ eriri afọ, antacids, ma ọ bụ enzyme. Okwesiri iburu n’uche na site na iji Glucobay n’otu ubochi ma obu insulin eme ihe, hypoglycemic mmetụta na-abawanye.

A na-atụ aro nke ukwuu ka ị ghara iji ngwa a yana thiazide diuretics, ọgwụ mgbochi, corticosteroids, nicotinic acid. Site na mmekorita ha, imebi oria shuga nwere ike ịmalite. Ọzọkwa, usoro ọmụmụ a nwere ike ịmalite ma ọ bụrụ na ị na-ewere phenothiazines, estrogens, isoniazids, ndị na-egbochi calcium channel, adrenomimetics n'otu oge dị ka Glucobai.

Mgbe ị na-eji mbadamba Glucobai, enwere ike ịpụta nke ụdị mmetụta ndị a:

1. Site na ngwe nri: mgbu epigastric, ọgbụgbọ, afọ ọsịsa, flatulence. N'ihe banyere ịdoụbiga mmanya ókè, enwere ike ịme mmụba asymptomatic na ọkwa ọrụ enzymes imeju. A makwaara mgbe ọrịa mgbochi afọ, ọrịa jaundice na ịba ọcha n'anya malitere n'oge ọgwụgwọ.
2. Mmeghachi omume nfụkasị ahụ.
3. Uwe.

N'ihe banyere ịdoụbiga mmanya ókè, mmeghachi omume anaphylactic nwere ike ịmalite. N'okwu a, a na-eme ọgwụgwọ symptomatic.

Ihe atụ kacha mma nke Glucobay

Ọ bụrụ na Glucobay na-contraindicated n'ihi ihe ọ bụla, mgbe ahụ, a na-ekenye onye ọrịa ahụ analogues otu ya. Obi abụọ adịghị ya, ụzọ kachasị mma maka ngwaọrụ a bụ Glucofage. A na-ejikwa ọgwụ a na ọgwụgwọ nke ọrịa shuga 1 na ụdị 2. Ọnụ ego ọgwụ dị na ụlọ ahịa ọgwụ bụ 500-700 rubles.

Ọtụtụ ndị mmadụ nwere mmasị na ihe dị iche na Glucofage na Glucobay. Isi ihe dị iche n'etiti ọgwụ ndị a bụ ihe mejupụtara na ụkpụrụ nke ime ihe. Ma ọgwụ abụọ ahụ dịkwa irè.

Kedu ka glucophage si arụ ọrụ? A na-akpọ akụkụ dị egwu nke ọgwụ ahụ metformin. Ihe a nwere mmetụta akpọ hypoglycemic mmetụta. Ọ bụ ihe kwesịrị ịrịba ama na n'ime ndị ọrịa nwere ọkwa shuga dị n'ọbara, metformin enweghị mmetụta hypoglycemic.

Usoro nke Glucofage sitere na ike nke ihe ọrụ ya dị elu iji mee ka uche nke mkpụrụ ndụ dị na insulin ma belata ọnụego glucose na ngọngọ nri. N'ihi ya, ọgwụ na-atụnye ụtụ na:

• Nkpirisi glucose di n’imeju.
• Mkpali nke iji glucose na akwara akwara.
• Mee ka metabolism dị mma.
• Cholesterol dị ala, triglycerides na lipoproteins, nke nwere njupụta dị ala.

Enwere ike iche Glucophage site na arụmọrụ ya na ọgwụ hypoglycemic ndị ọzọ. Nke a bụ n'ihi n'eziokwu na ọgwụ nwere ọgwụ bioavailability dị elu. Ha dị ihe dịka 50-60%. A na-ahụta nsonaazụ kachasị nke ọgwụ na-arụ ọrụ n'ime ọbara mgbe awa 2.5 gachara.

Etu esi ewere ogwu a? Ikwesiri ị tabletsụ mbadamba n’oge ma ọ bụ tupu nri. Dosebọchị kwa ụbọchị na-abụkarị gram 2-3 (2000-3000 milligrams). Ọ bụrụ na ọ dị mkpa, mgbe ụbọchị 10-15 gachara, a na-abawanye ma ọ bụ belata ogo ahụ. Ulo mmezi bụ 1-2 grams. Ọ dị mma ịmara na usoro ịchọrọ kwa ụbọchị nwere ike ịdị iche iche. N'ọtụtụ ụzọ, ọgwụ insulin na-ekpebi ya.

Amachibidoro ọgwụ a na:

1. Ihe nleghara anya maka ihe glucophage.
2. Odida ntaramahụhụ.
3. Imebi imeju.
4. Akpịrị ịkpọ nkụ.
5. Okpo iku ume.
6. Ọrịa na-efe efe.
7. Lactic acidosis.
8. Ọrịa mamịrị.
9. Nnukwu myocardial infarction (akụkọ ihe mere eme).
10. Nri Hypocaloric (ihe na-erughị kilogram 1000 kwa ụbọchị).
11. Ime na lactation.

Mgbe ị na-eji ọgwụ ahụ, nsogbu na-arụ ọrụ na ngwara nri, CCC na sistemụ hematopoietic nwere ike ịmalite. A ka nwere ike ọrịa metabolic. Ọtụtụ mgbe, mmetụta dị n'akụkụ na-apụta na oke oke.

Vidiyo dị n'isiokwu a na-ekwu banyere akụkụ dị mma na ọgwụ ọjọọ Glucobay.