Ọgwụ cholesterol na-ebelata ọgwụ: nyocha nke ndị ọrụ

Edere ọgwụ ogwu maka nsogbu Lipid ka arụrụ ọrụ, adịghị ike mmebe ahụ yana oke ibu maka ọnwa 6. N 'ọkwa nke cholesterol dị n'ọbara nke dị elu karịa 6.5 mmol / l, enwere ike ịkọwa ọgwụ tupu oge a.

Iji dozie metabolism lipid, a na-enye ọgwụ mgbochi atherogenic (lipid-lowering). Ebumnuche nke iji ha bụ iji belata ọkwa nke cholesterol "ọjọọ" (mkpokọta cholesterol, triglycerides, lipoproteins dị ala (VLDL) na njupụta dị ala (LDL))), nke na-ebelata mmepe nke vaskụla atherosclerosis ma belata ihe ngosipụta nke ngosipụta ya: angina pectoris, nkụchi obi, ọrịa strok na ndị ọzọ ọrịa.

Nkewa

1. Nchịkwa mgbanwe nke Anion na ọgwụ ndị na -ebelata mmịcha (nnabata) nke cholesterol na eriri afọ.
2. Nicotinic acid
3. Probukol.
4. Fibrates.
5. Statins (3-hydroxymethyl-glutaryl-coenzyme-A-reductase inhibitors).

Dabere na usoro eji eme ihe, enwere ike ike ọgwụ iji belata cholesterol ọbara dị iche iche.

Ọgwụ ndị na-egbochi njikọ lipoproteins atherogenic ("cholesterol ọjọọ)":

• akpụ
• fibrates
• nicotinic acid
• probucol,
• benzaflavin.

Nke pụtara na ọ na -ewe iwelata cholesterol na nri n'ime eriri afọ:

• usoro nke bile acid,
• njigide.

Ndị na-edozi metabolism nke na-abawanye “ọkwa cholesterol dị mma”:

Ndị na - eme usoro nke bile acids

Ọgwụ Bile acid na-ejikọ mkpụrụ ọgwụ (cholestyramine, colestipol) bụ mkpogharị mgbanwe anion. Ozugbo n'ime eriri afọ, ha "na - ejide" bile acid ma wepụ ya n'ahụ. Ahụ mmadụ malitere enweghị acid bile, nke dị mkpa maka ịrụ ọrụ nkịtị. Ya mere, n'ime imeju, a na-amalite usoro ịwakọta ha na cholesterol. A na - ewere cholesterol "n'ọbara, n'ihi nke a, itinye uche ya ebe ahụ na - agbada.

Cholestyramine na colestipol dị n'ụdị akwa. A ga-ekewa ọgwụ kwa ụbọchị ka ọ dị ntụtụ 2 ruo 4, na-eri site na dilring ọgwụ na mmiri mmiri (mmiri, ihe ọ juiceụ )ụ).

Anaghị etinye mkpụrụ osisi mgbanwe iji abanye n'ọbara, na-eme naanị na eriri afọ. Ya mere, ha dị mma nchekwa mana enweghị nnukwu mmetụta anaghị achọ ya. Ọtụtụ ndị ọkachamara kwenyere na ọ dị mkpa ịmalite iji ọgwụ ndị a agwọ hyperlipidemia.

Nsonaazụ gụnyere nsị, ọgbụgbọ na afọ ntachi, oche na-adịghị ala ala. Iji gbochie ụdị mgbaàmà ndị a, ọ dị mkpa iwelie oriri nke mmiri na nri (fiber, bran).
Site na iji ọgwụ ndị a ogologo oge na oke doses, enwere ike imebi nnabata na eriri afọ nke folic acid na ụfọdụ vitamin, tumadi abụba.

Ọgwụ ndị na-egbochi ịmịnye mkpụrụ ndụ cholesterol

Site n’ibelata iwere cholesterol n’ihe oriri n’ime eriri afọ, ọgwụ ndị a na-ebelata itinye uche n’ime ọbara.
Nke kacha dị irè n ’ị nweta ego a bụ guar. O bu ihe ndi ozo sitere na nkpuru nke hyacinth agwa. O nwere polysaccharide mmiri na-agbanye mmiri, nke na-akpụ jelii mgbe kọntaktị na mmiri nwere eriri afọ.

Guarem na - ewepu cholesterol ụmụ irighiri mgbidi na eriri afọ. Ọ na - eme ka mkpocha acid na - eme ka ihe ghara ịdị ike, na - eduga n'ịba ụba nke kọlesterol site n'ọbara banye na imeju maka njikọ ha. Ọgwụ na-egbochi agụụ iri nri ma na -ebelata oke nri ị na-eri, nke na-eduga n’ibelata oke ibu na oke oke mmiri.
A na -emepụta Guarem na granules, nke ekwesịrị ịgbakwunye ya na mmiri mmiri (mmiri, ihe ọ juiceụ ,ụ, mmiri ara ehi). Shouldakingụ ọgwụ ahụ kwesịrị ijikọ ya na ọgwụ ndị ọzọ antiatherosclerotic.

Mmetụta ndị ọ na-enwe na-agụnye ịmịcha mmiri, ọgbụgbọ, mgbu n'ime eriri afọ, na mgbe ụfọdụ oche tọgbọrọ chakoo. Agbanyeghị, ha na-egosipụta obere, ọ na - adịkarị, na - aga n'ihu na - agafe onwe ha.

Nicotinic acid

Nicotinic acid na ihe ndị dị na ya (enduracin, niceritrol, acipimox) bụ vitamin nke otu B. Ọ na-ebelata mkpụkọ 'cholesterol ọjọọ' n'ime ọbara. Nicotinic acid na - eme ka usoro fibrinolysis na - arụ ọrụ, na - ebelata ikike ọbara na - emepụta mkpụkọ ọbara. Ngwọta a bara uru karịa ọgwụ ndị ọzọ na-eme ka mmụba dị elu na -eme ka mmụba nke "ezigbo cholesterol" dị n'ọbara.

A na-eme ọgwụgwọ Nicotinic acid ogologo oge, yana mmụba nwayọ nwayọ na dose ahụ. Tupu na mgbe ị takingụchara ya, a naghị atụ aro ị drinkụ ihe ọ hotụ hotụ na-ekpo ọkụ, karịsịa kọfị.

Ọgwụ a nwere ike imebi afọ, yabụ, edeghị ya maka eriri afọ na ọnya afọ. N'ọtụtụ ndị ọrịa, ịcha ọbara ọbara na-apụta na mmalite ọgwụgwọ. Nke nta nke nta, mmetụta a na-apụ n'anya. Iji gbochie ya, a na-atụ aro ka ọ were 325 mg nke ọgwụ aspirin minit 30 tupu ị theụ ọgwụ ahụ. 20% nke ndị ọrịa nwere akpịrị isi awọ.

A na - egbochi ọgwụgwọ nke nicotinic acid maka ọnya afọ nke afo na duodenum, ịba ọcha n'anya, nnukwu obi ọgbụgba obi, gout.

Enduracin bụ ọgwụ nicotinic acid na-eme ogologo oge. Anabatachaghi ihe ọ bụla, na-ebute obere nsonaazụ. Enwere ike ịgwọ ha ogologo oge.

Ọgwụ ahụ na-ebelata ọkwa nke cholesterol abụọ “dị mma” na nke “jọrọ njọ”. Ọgwụ anaghị emetụta ọkwa nke triglycerides.

Ọgwụ na-ewepụ LDL n'ọbara, na-eme ka cholesterol dị na bile ngwa ngwa. Ọ na-egbochi peroxid lipid, na-egosipụta mmetụta antiatherosclerotic.

Mmetụta nke ọgwụ ahụ na-apụta ọnwa abụọ mgbe mmalite nke ọgwụgwọ ma dịruru ọnwa isii ka ejiri kwụsị ya. Enwere ike ijikọ ya na ụzọ ọ bụla ọzọ iji belata cholesterol.

N'okpuru mmetụta nke ọgwụ ahụ, ogologo oge nke oge Q-T na electrocardiogram na mmepe nke ventricular arrhythmias siri ike ga-ekwe omume. N'oge nchịkwa ya, ọ dị mkpa ikwugharị electrocardiogram ọbụlagodi ugboro 3 ruo ọnwa isii. Cannweghị ike kenye probucol n'otu oge na cordarone. Ihe ndị ọzọ a na-achọghị na-agụnye gụnyere ọbara mgbu na afọ, ọgbụgbọ, na mgbe ụfọdụ oche tọgbọrọ chakoo.

A machibidoro probucol na arrhythmias ventricular metụtara oge Q-T gbatịkwuru, akụkụ oge mgbe ọ bụla nke ischemia myocardial, yana kwa ọkwa HDL nke dị ala.

Fibrates na -ebelata ọkwa nke triglycerides n'ime ọbara, ruo na obere obere mkpokọta nke LDL cholesterol na VLDL. A na-eji ha mee ihe n'ọnọdụ nnukwu hypertriglyceridemia. Ngwá ọrụ ndị a na-ejikarị eme ihe bụ:

• gemfibrozil (loused, gevilon),
• fenofibrate (lipantil 200 M, treicor, ex-lipip),
• cyprofibrate (lipanor),
• choline fenofibrate (trilipix).

Nsonaazụ gụnyere mmerụ ahụ (mgbu, adịghị ike), ọgbụgbọ na mgbu afọ, ọrụ imeju na-arụ ọrụ. Fibrates nwere ike ịkwalite nguzobe nke calculi (nkume) n’ime eriri afọ. N'ọnọdụ ndị a na-adịghị ahụkebe, n'okpuru nduzi nke ndị ọrụ ndị a, mgbochi nke hematopoiesis pụtara mmepe nke leukopenia, thrombocytopenia, anaemia.

Achọghị Fibrates maka ọrịa nke imeju na eriri afọ, hematopoiesis.

Statins bụ ọgwụ kachasị dị ala na-akụda ike. Ha na-egbochi enzyme nke na-akpata cholesterol n'ime imeju, ebe ọdịnaya ya na ọbara na-ebelata. N'otu oge ahụ, ọnụọgụ nke ndị na-anabata LDL na-abawanye, nke na-eduga n'ịgbapụta ngwa ngwa nke "cholesterol ọjọọ" site n'ọbara.
Ọgwụ ndị a na-edekarị bụ:

• simvastatin (vasilip, zokor, aries, simvageksal, simvakard, simvakol, simvastin, simvastol, simvo, simlo, sincard, holvasim),
• lovastatin (kadiostatin, choletar),
• pravastatin
• atorvastatin (anvistat, atocor, atomax, ator, atorvox, atoris, vazator, lipoford, lypimar, liptonorm, novostat, torvazin, torvakard, tulip),
• rosuvastatin (akorta, obe, mertenil, rosart, rosistark, rosucard, rosulip, roxera, rustor, tevastor),
• pitavastatin (livazo),
• fluvastatin (leskol).

A na-eji Lovastatin na simvastatin mee ihe. Ndị a bụ “prodrugs” nke imeju na-agbanwe metabolites na-arụ ọrụ. Pravastatin bụ usoro nke metabolites fungal, mana ọnaghị metabolized n'ime imeju, mana ọ bụlarị ihe na-arụ ọrụ. Fluvastatin na atorvastatin bụ ọgwụ sịntetik zuru oke.

A na-ahazi statins otu ugboro n’ụbọchị na mgbede, ebe ọ bụ na oke cholesterol dị n'ahụ na-apụta n'abalị. Nke nta nke nta, usoro ha nwere ike ịba ụba. Nsonaazụ ahụ emeelarị n’ụbọchị mbụ nke nchịkwa, rute otu kachasị n’otu ọnwa.

Statins adịghị mma. Agbanyeghị, mgbe ị na-eji nnukwu onyunyo, ọkachasị yana yana fibrates, ọrụ imeju na-arụ ọrụ ga-ekwe omume. Patientsfọdụ ndị ọrịa na-enwe obi mgbu na ike akwara. Mgbe ụfọdụ enwere mgbu afọ, ọgbụgbọ, afọ ntachi, enweghị agụụ. N'ọnọdụ ụfọdụ, ehighị ụra na isi ọwụwa.

Statins anaghị emetụta metabolism na metabolism. Enwere ike ịkọ ha maka gout, ọrịa shuga, oke ibu.

Statins bụ akụkụ nke ụkpụrụ maka ọgwụgwọ nke atherosclerosis. Edere ha dị ka monotherapy ma ọ bụ na njikọta na ndị ọzọ antiatherosclerotic. Enwere ngwakọta a kwadebere maka lovastatin na nicotinic acid, simvastatin na ezetimibe (ingee), pravastatin na fenofibrate, rosuvastatin na ezetimibe.
Njikọ nke statins na acetylsalicylic acid, yana atorvastatin na amlodipine (duplexor, caduet) dị. Ojiji nkwakọba a kwadebere na-eme ka mmadụ ịgbasochi ọgwụgwọ anya (irube isi), na-aba uru karịa nke akụ na ụba, ma na-akpata mmetụta dị ole na ole.

Ọgwụ ndị ọzọ na-eme ka egbusi ike gwụ

Benzaflavin bụ otu nke vitamin B2. Ọ na - eme ka metabolism dị na imeju, na - ebute mbelata ọbara mgbali elu, triglycerides, cholesterol zuru oke. A na-anabata ọgwụ ahụ nke ọma, edepụtara ya n'ọtụtụ ọmụmụ.

Mkpa nwere phospholipids dị mkpa, vitamin B, nicotinamide, acid na-enweghị afọ ojuju, sodium pantothenate. Ọgwụ na-emezi mmebi na mkpochapu cholesterol nke "ọjọọ", na-eme ka akụrụngwa bara uru nke cholesterol dị mma.

Lipostable dị nso na usoro na ihe dị Mkpa.

A na-enye Omega-3 triglycerides (omacor) maka ịgwọ ọrịa hypertriglyceridemia (ewezuga ụdị hyperchilomicronemia nke 1), yana maka mgbochi nke ugboro ugboro myocardial infarction.

Ezetimibe (ezetrol) na-egbu oge ịnwe cholesterol na eriri afọ, na -ebelata oriri ya na imeju. Ọ na --ebelata ọdịnaya nke cholesterol "ọjọọ" n'ime ọbara. Ọgwụ a kachasị dị mma na njikọta na statins.

Vidiyo na isiokwu "Cholesterol na statins: ọ bara uru ị theụ ọgwụ?"