Lisinopril - kedu ọgwụ ndị a si? Ntụziaka maka iji, analogues, nyocha

Ntụziaka maka ojiji:

Ọnụ ahịa ahịa ahịa n'ịntanetị:

Lisinopril bụ angiotensin na-agbanwe enzyme (ACE) inhibitor na-ebelata nguzobe nke angiotensin II na angiotensin nke mbụ.

Mwepụta wepụtara ya na ihe mebere

Sdị usoro Lisinopril usoro onunu ogwu - mbadamba: gburugburu, gburugburu, nwere ọnụ beveled, nwere ihe egwu n’otu akụkụ (PC 10. Na blisters, na ngwongwo kaadiboodu 2, 3, 4, 5 ma ọ bụ 6, pọọsụ 14). ngwungwu ekwentị, na ngwugwu nke 1, 2, 3 ma ọ bụ 4 ngwugwu).

Ihe na-arụ ọrụ nke ọgwụ ahụ bụ lisinopril n'ụdị nke mmiri mmiri na-egbu mmiri. Ọdịnaya ya na mbadamba ụrọ, dabere na agba:

• Osisi gbara ọchịchịrị 2.5 mg
• Oroma 5 mg
• Pink - 10 mg
• Ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha - 20 mg.

Ihe inyeaka: lactose monohydrate, stachi ọka, methylene chloride, povidone, magnesium stearate. Na mbadamba ụrọ nke 2.5 na 5, na mgbakwunye, a na-acha ụzarị anyanwụ ọdịda, na mbadamba 10 mg - dye azorubine, na mbadamba 20 mg - titanium dioxide.

Ihe ngosi maka ojiji

• Na mbido (n'ime awa iri abụọ na anọ) banyere nnukwu ọrịa myocardial infarction na ndị ọrịa nwere oke hemodynamic kwụ ọtọ (dịka akụkụ nke njikọta ọgwụ iji jigide ihe ngosi ndị a ma gbochie obi nkụda mmụọ na ọnyụnyụ ọrụ aka ekpe),
• Ọrịa obi na-adịghị ala ala (dị ka akụkụ nke usoro ọgwụgwọ mgbagwoju anya),
• Ọrịa ọbara ọgbụgba na akwara dị mkpa (dị ka otu ọgwụ ma ọ bụ ọgwụ yana ọgwụ ndị ọzọ na - egbochi mmiri).
• Ọrịa mamịrị na-arịa ọrịa shuga (iji belata albuminuria na ndị ọrịa nwere ụdị ọrịa shuga mellitus nke nwere ọbara mgbali nkịtị na ndị ọrịa nwere ụdị ọrịa shuga II nke nwere ọbara mgbali elu).

Ihe ngbanwe

• Ebumatụrụ na akụkụ ịmụ azụ ma ọ bụ Quincke angioedema,
• Akụkọ banyere anakedeede, gụnyere n'ihi ojiji nke ACE inhibitors,
• Lactose anabataghị, glucose-galactose malabsorption, ụkọ lactase,
• N’agbata afọ 18
• Ime
• Lactation
• Akpachapụ anya na akụkụ nke ọgwụ ahụ ma ọ bụ ndị ọzọ na-egbochi ACE.

Mmekọrịta (nlekọta ọzọ chọrọ):

• Agadi
• Ọkpụkpụ obi na-egbochi hypertrophic,
• Stenosis nke aortic orifice,
• Ike ọbara,
• Ọrịa obi na-ekweghị ala,
• Ọrịa obi
• Ọrịa Cerebrovaskụla (gụnyere ụkọ nke ụbụrụ),
• Ihe mgbochi nke ụmị ọkpụkpụ,
• Isi hyperaldosteronism,
• Ọrịa shuga mellitus
• Oria ọrịa nke anụ ahụ jikọrọ ya (gụnyere scleroderma na systemic lupus erythematosus),
• Hyperkalemia
• Hyponatremia,
• Ọnọdụ Hypovolemic (gụnyere afọ ọsịsa na vomiting),
• Abụọ na akwara mkpụrụ ndụ stenosis ma ọ bụ stenosis nke otu akụrụ akwara, nnukwu akụrụ gbasara akwara (mwepụ nke na-erughi 30 ml / min), ọnọdụ mgbe ọ gbasesịrị akụrụ,
• Hemodialysis, nke na - eji membranes dialysis di elu (AN69).

Usoro onunu ogwu na nhazi

Ekwesịrị iwere Lisinopril ugboro 1 kwa ụbọchị, n'agbanyeghị nri nri, mana ọkacha mma n'otu oge ahụ.

Ọgwụ nke ọbara ọgbụgba dị mkpa na-ebido n ’ọgwụ kwa ụbọchị nke 10 mg. Dosegwọ mmezi ahụ bụ mgụ iri abụọ, ọgwụ kacha mkpa kwa ụbọchị bụ 40 mg. Na mmụba na dose, ọ dị mkpa ịtụle na nkwụsi ike hypotensive amalite mgbe ọnwa 1-2 gachara. Ọ bụrụ na mgbe ị na-a theụ ọgwụ kwa ụbọchị ezughi oke, ọgwụ ndị ọzọ na-ahụ maka ọgwụ mgbochi oke enwere ike. Ọrịa ndị natara ọgwụ diuretics, ụbọchị 2-3 tupu nhọpụta nke ọgwụ a, a ga-ahapụrịrị ya. Ọ bụrụ na nke a agaghị ekwe omume, mgbe ahụ ọgwụ mbụ nke Lisinopril ekwesịghị gafere 5 mg kwa ụbọchị.

Ọgwụ izizi maka ọbara mgbali elu na ọnọdụ ndị ọzọ na-arụ ọrụ na-arụ ọrụ nke sistemụ renin-angiotensin-aldosterone bụ 2.5-5 mg kwa ụbọchị. A na-eme ọgwụgwọ n'okpuru nchịkwa nke ọrụ akụrụ, ọbara mgbali (BP), potassium. Dọkịta na-ekpebi usoro mmezi dabere na ọbara mgbali elu. Na ọdịda akụrụ na-adịghị ala ala, a na-ekpebi ọgwụ kwa ụbọchị dabere na mwepụ nke creatinine (CC): yana CC 30-70 ml / min - 5-10 mg, ya na CC 10-30 ml / min - 2.5-5 mg, yana CC erughị 10 ml / nkeji na ndị ọrịa na-anata ụdị ịba ọcha n'anya - 2.5 mg. Ọkwa mmezi dabere na ọbara mgbali elu.

Treatmentgwọ ọrịa obi na-adịghị ala ala na-ebido site na iji ọgwụ 2,5 mg kwa ụbọchị (n'otu oge na cardiac glycosides na / ma ọ bụ diuretics). Na oge nke ụbọchị 3-5, ọ na-eji nwayọọ nwayọọ mụbaa - site na 2.5 mg - ruo mgbe a ga-enweta ọgwụ mmezi nke 5-10 mg kwa ụbọchị. Ogo ị na-anabata kwa ụbọchị bụ 20 mg. Ọ bụrụ na ọ ga-ekwe omume, ekwesịrị belata dose nke diuretic tupu iwere Lisinopril.

N'ime ndị okenye, a na-ekwukarị na ọ nwere mmetụta hypotensive nwere ogologo oge, ya mere a na-atụ aro ọgwụgwọ ịmalite kwa ụbọchị nke 2.5 mg. Na nnukwu myocardial infarction, a na-enye 5 mg ọgwụ n'ime awa 24 mbụ, 5 mg na otu ụbọchị, 10 mg n'ime ụbọchị abụọ ọzọ na 10 mg otu ugboro kwa ụbọchị, usoro ọgwụgwọ kacha nta bụ izu isii. N'ihe banyere mbelata nrụgide systolic na 100 mm RT. Art. ma belata ọgwụ a belata na 2.5 mg. Site na ogologo oge (karịa elekere 1) na-akpọ mbelata mgbali systolic n'okpuru 90 mm RT. Art. a na-akagbu ọgwụ ahụ. Maka ndị ọrịa nwere nrụgide systolic dị ala (120 mmHg. Art. Na nke dị n'okpuru), a na-enye 2.5 mg ọgwụ mbụ n'ime ụbọchị atọ mbụ mgbe ọ gbasịrị nnukwu myocardial infarction ma ọ bụ na mmalite ọgwụgwọ.

Ọgwụ izizi maka nephropathy mamịrị bụ 10 mg kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, a na-amụba ya ka 20 mg: ka ndị ọrịa nwere ụdị ọrịa shuga mellitus wee ruo ihe na-egosi nrụgide diastolic n'okpuru 75 mm Hg. Art., Na ndị ọrịa nwere ụdị ọrịa mellitus nke II - dị n'okpuru 90 mm RT. Art. A na-agbanye mgbali nrụgide n'oche.

Nsonaazụ

Nsonaazụ kachasị emetụta: ike ọgwụgwụ, isi ọwụwa, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, ụkwara akọrọ.

• Usoro obi: mbelata ọbara mgbali, bradycardia, tachycardia, palpitations, mgbu obi, mgbakasị ahụ ụzọ mbido, mmalite ma ọ bụ na-akawanye njọ nke mgbaàmà obi dara ada, ọbara orthostatic hypotension, infarction myocardial,
• Sistemụ akwara: ụjọ ijiri egbugbere ọnụ na akwara ozi, paresthesia, asthenic syndrome, ntị ike ọgwụgwụ, ike ọgwụgwụ, mmetụta mmụọ, iro ụra, ọgba aghara,
• Usoro nri: ngbanwe nke uto, mucosa a na-ede ede, mgbu nwa, dyspepsia, anorexia, jaundice (cholestatic ma ọ bụ hepatocellular), pancreatitis, ịba ọcha n'anya,
• Usoro mkpụrụ ndụ: anuria, oliguria, proteinuria, uremia, ọrụ ezughi oke, akụrụ gbasara akwara ịda mba, obere ikike,
• Usoro iku ume: akọrọ ụkwara, dyspnea, bronchospasm,
• Sistem hematopoietic: agranulocytosis, neutropenia, thrombocytopenia, leukopenia, anaemia (erythropenia, wedata haemoglobin, hematocrit),
• Akpukpo aru: photoensitivity, alopecia, iribiga elu, itching,
• Mmeghachi omume Allergic: angioedema nke nsọtụ, ihu, egbugbere ọnụ, ire, epiglottis na / ma ọ bụ larynx, akpụkpọ ahụ, urticaria, ESR mụbara, ahụ ọkụ, eosinophilia, nsonaazụ nyocha dị mma maka ọgwụ mgbochi antinuclear, leukocytosis, angioedema eriri afọ,
• Ndị ọzọ: ogbu na nkwonkwo / ọrịa ogbu na nkwonkwo, myalgia, vasculitis,
• Ihe ngosi nke ulo-akwukwo: ubara oru nke hepatic transaminases, hyperbilirubinemia, hyponatremia, hypercreatininemia, hyperkalemia, mụbara urea.

N'iji oge nke nkwadebe ọla edo (sodium aurothiomalate) introven with AC inhibitor, akọwapụtara ihe mgbaàmà, gụnyere ọgbụgbọ na ọgbụgbọ, ọpụpụ ihu, hypotension arterial.

Ntụziaka pụrụ iche

Lisinopril bụ contraindicated na cardiogenic ujo na nnukwu myocardial infarction, ma ọ bụrụ na vasodilator nwere ike ịka njọ paradaịs hemodynamic, dịka ọmụmaatụ, mgbe ọbara mgbali systolic karịrị 100 mm Hg. Art.

Mbelata ọbara mgbali elu mgbe ị na-a theụ ọgwụ ọgwụ na - apụtakarị na mbelata nke olu na - ekesa ọbara (BCC) n'ihi ojiji nke ị diụ ọgwụ, ọnya afọ ma ọ bụ vomiting, hemodialysis, na mbelata nke nnu nnu na nri. Ndị ọrịa nwere nkụchi obi na -ewekarịkwa ọrịa nwere mbelata ọbara mgbali elu. Ọtụtụ mgbe ka achọpụtara ya na ndị ọrịa nwere nnukwu olu nke ọrịa obi na-adịghị ala ala n'ihi hyponatremia, ọrụ ezumike na-arụ ọrụ ma ọ bụ na-a diụ ọgwụ ndị dị elu. Egosipụtara na ndị ọrịa akọwapụtara na mmalite ọgwụgwọ ga-enyocha nlekọta ahụike siri ike, nhọrọ nke Lisinopril na diuretics kwesịrị iji nlezianya buru ibu. A ga-agbaso iwu ndị yiri ya mgbe ị na-edepụtara ndị ọrịa nwere ọrịa obi na ọrịa ụbụrụ, na oke mbelata ọbara mgbali elu nwere ike ibute ọrịa strok ma ọ bụ infarction myocardial. Tupu ịmalite ọgwụgwọ, a na-atụ aro ka ịhazie mkpokọta sodium n'ọbara na / ma ọ bụ tụgharịa bcc, wee jiri nlezianya nyochaa mmetụta nke ọgwụ mbụ.

N'ime ọgwụgwọ nke hypotension Symptomatic arterial hypotension, ekwesịrị inye izu ike, ma ọ bụrụ na ọ dị mkpa, a na-enye usoro nchịkwa nke mmiri mmiri (saline). Ọgwụ hypotension transient abụghị ọgwụ Lisinopril, kama ọ nwere ike ịchọ mbelata ọgwụ ma ọ bụ ịkwụsị ọgwụ ahụ.

Ọrụ akụrụngwa belata (mkpokọta plasma creatinine karịa 177 μmol / L na / ma ọ bụ proteinuria karịa 500 mg / 24 awa) na ndị ọrịa nwere nnukwu myocardial infarction bụ ihe mgbochi megide iji Lisinopril. Site na mmepe nke ọdịda akụrụngwa (nsonaazụ plasma creatinine karịa 265 μmol / L ma ọ bụ ugboro abụọ dị elu karịa ọkwa mbụ) n'oge ị withụ ọgwụ a, dọkịta ahụ kpebiri ma ịkwụsị ọgwụgwọ.

Ọrịa Angioedema nke akụkụ ahụ, ihu, ire, egbugbere ọnụ, epiglottis na / ma ọ bụ nkọlọ bụ ihe na-adịghị ahụkebe, mana enwere ike ime n'oge ọ bụla n'oge ọgwụgwọ. N'okwu a, aga-akwụsị ọgwụgwọ ozugbo ma jiri nlezianya nyochaa onye ọrịa ruo mgbe mgbaàmà ya na-amalite kpamkpam. Udere nke Laryngeal nwere ike igbu egbu. Ọ bụrụ na ekpuchichichaa akpịrị, epiglottis, ma ọ bụ ire, enwere ike ịmachi ikuku, yabụ, usoro ọgwụgwọ kwesiri ekwesi na / ma ọ bụ usoro iji hụ na pataka ikuku dị mkpa.

Mgbe ejiri ya na ndị na - egbochi ACE, enwere ike ibute ọrịa agranulocytosis, yabụ ọ dị mkpa ijikwa foto ọbara.

N'ihe banyere mmụba nke ọrịa hepatic transaminases ma ọ bụ ọdịdị nke mgbaàmà nke cholestasis, ọgwụ ahụ kwesịrị ịkwụsị. enwere ihe ọghọm nke ịmalite ịrịa ọrịa cholestatic jaundice, na-aga n'ihu na necrosis imeju.

Oge ọgwụgwọ niile kwesịrị ịhapụ ị ofụ ihe ọholicụ alcoụ na-aba n'anya, ma kpachara anya na ihu igwe na-ekpo ọkụ na mgbe ị na-eme mmega ahụ. akpịrị ịkpọ nkụ na mbelata ọbara mgbali ga-ekwe omume.

Dabere na ọmụmụ epidemiological, ojiji nke ACE inhibitors na insulin ma ọ bụ ọnụ hypoglycemic na-elekọta mmadụ nwere ike iduga mmepe nke hypoglycemia, karịsịa n'ime izu ndị mbụ nke usoro njikọta, yana ndị ọrịa nwere ọrụ mgbazinye nsogbu. Maka nke a, ndị ọrịa na-arịa ọrịa shuga kwesịrị iji nlezianya nyochaa glycemia, karịsịa ọnwa mbụ nke iji Lisinopril.

Ọ bụrụ na nsonaazụ ndị sitere na sistemụ akwara Central, a na-atụ aro ka ọ ghara ịkwọ ụgbọala na ịrụ ụdị ọrụ nwere ike dị egwu.

Mkparịta ụka ọgwụ ọjọọ

Ndị na-egbochi Beta-blockers, ihe ndị na-eme ka ọnụnọ ya, ndị na-egbochi ọwa calcium na-egbochi ngwa ngwa na ọgwụ ọgwụ ndị ọzọ na-egbochi ọgwụ ike nke Lisinopril.

Iji n'otu oge eji eme ihe maka potassium, ndị na-edochi nnu nwere potassium ma ọ bụ ihe ndị na-egbu ya (amiloride, triamterene, spironolactone), ihe ize ndụ nke ịmalite hyperkalemia na-abawanye, ọkachasị ndị ọrịa nwere ọrụ mgbazinye nsogbu. Maka nke a, ọ bụ naanị dọkịta kwesịrị ịkọpụta ụdị njikọ a, a ga-arụkwa ọgwụgwọ n'okpuru nleba anya mgbe niile gbasara ọrụ akụrụ yana ịta ọka potassium.

N'iji nke vasodilators, barbiturates, antidepressants tricyclic, phenothiazine na ethanol, na-eme ka mmetụta antihypertensive nke Lisinopril dịkwuo mma. Antacids na colestyramine na -ebelata mwepu ya na eriri afọ.

Ọgwụ mgbochi mkpali na - anaghị egbochi ọgwụ (gụnyere cyclooxygenase-2 inhibitors), adrenostimulants na estrogens belatara mmetụta hypotensive nke ọgwụ ahụ.

Site n'iji lisinopril na-eme n'otu oge, ọ na-ebelata ekpomoku nke lithium n'ahụ, n'ihi nke akwara obi ya na mmetụta neurotoxic na-eme ka ọ dịkwuo mma.

Iji nkwonkwo methyldopa mee ihe nwere ike iduga mmepe nke hemolysis, yana nhọrọ serotonin reuptake inhibitors - na hyponatremia siri ike, ya na cytostatics, procainamide, allopurinol - na leukopenia.

Lisinopril na - eme ka ihe ndị dị na mwepu anụ ahụ dịkwuo ala, na - ebelata ịdị irè nke ọgwụ mgbochi, na - ebelata ngbanwe nke quinidine, na - ebuli neurotoxicity nke salicylates, na - akụda nsonaazụ nke ọgwụ hypoglycemic ọgwụ, epinephrine (adrenaline), norepinephrine (norepinephrine) na-eme ka ọ na-abawanye ọgwụ, ọ na-eme ka a na-eme ka a rụpụta ọgwụ a na-akwụ na-aga, ọ na-eme ka ihe a na-aga n'ihu nke a, .

Site na iji Lisinopril na-eme n'otu oge yana ịkwado ọla edo, ọ ga-ekwe omume ịmalite hyperemia nke ihu, ọgbụgbọ na ọgbụgbọ na hypotension.

Effects nwere ike ọghọm ya

N'ọnọdụ ọ bụla, ọ bara uru iji nlezianya were mbadamba nkume Lisinopril. Ntụziaka ahụ na-egosiputa ihe nwere ike ọghọm ndị nsonaazụ ndị a:

• isi ọwụwa, anya isi,
• ọgbụgbọ, afọ ọsịsa,
• ike ọgwụgwụ,
• akọrọ ụkwara.

Ọ dịkarịghị ahụkarị ụdị ọgwụ a:

1. Egwu, ọgba aghara.
2. Obi mgbu, mkpụmkpụ ume, bronchospasm.
3. Bradycardia
4. Ọduọ ọbara ọbara na mberede.
5. Ọsụsọ mụbara.
6. Akwara mgbu, ịma jijiji, nsogbu.
7. Ibelata ntutu.
8. Ọgwụ mgbochi nke ultraviolet radieshon.
9. Mmeghachi omume nfụkasị ahụ.
10. Mgbanwe na ọnụ ọgụgụ ọbara.

Tupu ị theụ ọgwụ ahụ, gwa dọkịta gị. Ọ ga-ahọrọ gị usoro ọgwụgwọ kwesịrị ekwesị maka gị. Nke a ga - enyere aka belata ihe egwu dị na nsonaazụ ya.

Omume ọgwụ

Lisinopril na-abawanye ụda nke arịa ịwa elu ma na-akwalite izoputa adrenal nke aldosterone. Site na iji mbadamba ihe, vasoconstrictor nke hormone angiotensin na-ebelata nke ukwuu, ebe n'ọbara plasma ọbara na-ebelata aldosterone.

Drugụ ọgwụ ahụ na-enyere aka belata ọbara mgbali elu, na agbanyeghị ọnọdụ anụ ahụ (iguzo ọtọ, ịgha ụgha). Lisinopril na-ezere ihe omume nke reflex tachycardia (mgbanwe obi obi).

Mbelata ọbara mgbali elu n'oge ị na-a medicationụ ọgwụ ọ bụla na-enwe obere ọdịnaya nke renin na plasma ọbara (homonụ guzobere akụrụ).

Ngwongwo ogwu

Mmetụta nke ọgwụ a na-ahụpụta n'ime otu elekere mgbe nchịkwa ọnụ ya gasịrị.Mmetụta kachasị nke Lisinopril na-ahụkarị 6 awa mgbe nchịkwa gasịrị, ebe mmetụta a na-aga n'ihu na ụbọchị ahụ dum.

Akwụsị ọgwụ a nke ọma anaghị ebute mmụba ọbara ngwa ngwa, mmụba ahụ nwere ike ọ gaghị adị ala ma e jiri ya tụnyere ọkwa ahụ tupu mmalite ọgwụgwọ.

Ọ bụrụ na-eji Lisinopril ndị ọrịa na-arịa nkụchi obi, na myirịta na digitalis na diuretic therapy, ọ nwere mmetụta na-esote: ọ na-ebelata nguzogide arịa arịa, na-abawanye ọnya na nkeji ọbara (na-enweghị na-abawanye obi), na-ebelata ibu na obi, na-amụba anụ ahụ na-anabata nrụgide anụ ahụ. .

Ọgwụ ahụ na –emeziwanye akwara ume intrarenal. Ntinye ọgwụ a na - apụta site na akwara afọ, ebe a na-ahụ itinye mgbanye ya kachasị na ọbara n'ọtụtụ awa isii ruo awa asatọ mgbe ọ jisịrị nchịkwa.

Ntụziaka maka ojiji

Lisinopril (ihe ndị na-egosi na ị takingụ ọgwụ dịgasị iche) dị na mbadamba ụrọ nke nwere mg mg 5, 5 mg, 10 mg na 20 mg nke ihe ahụ na - arụ ọrụ. Were ntuziaka Lisinopril otu ugboro n’ụbọchị, ọkacha mma n’otu oge.

Ojiji nke ọgwụ ahụ maka ọbara mgbali elu dị mkpa kwesịrị ịmalite site na 10 mg kwa ụbọchị, na-esochi ntụgharị gaa na usoro mmezi nke 20 mg kwa ụbọchị, ebe n'ọnọdụ ndị dị oke njọ, a na-ahapụ ogo kwa ụbọchị nke 40 mg.

Nyocha banyere lisinopril na-egosi na mmetụta ọgwụgwọ zuru oke nke ọgwụ nwere ike ịmalite izu 2-4 mgbe mmalite ọgwụgwọ. Ọ bụrụ na mgbe itinye ọgwụ kachasị elu nke ọgwụ ahụ arụpụtaghị ihe ndị a tụrụ anya na arụpụtaghị, a na-atụ aro ịakeụ ọgwụ ndị ọzọ antihypertensive.

Ndị ọrịa na-a diụ ọgwụ mkpụrụ ọgwụ, ụbọchị 2-3 tupu mmalite nke iji Lisinopril, ị ga-akwụsị ị themụ ha. Ọ bụrụ na n'ihi ihe ụfọdụ kagbuo diuretics agaghị ekwe omume, a ga-ebelata ọgwụ kwa ụbọchị nke lisinopril na 5 mg.

Na ọnọdụ ịba ụba nke sistemụ renin-angiotensin-aldosterone nke na-achịkwa oke ọbara na ọbara mgbali, Lisinopril na-atụ aro ka iji ọgwụ kwa ụbọchị nke 2.5-5 mg. A na-edobe ndozi nke ọgwụ maka ọrịa ndị a n'otu n'otu dabere na uru ọbara mgbali elu dị.

Etu esi ewere ọrịa

Na ọdịda akụrụngwa, ọgwụ kwa ụbọchị nke lisinopril na-adabere na iwepupụta creatinine ma nwee ike ịdị iche site na 2.5 ruo 10 mg kwa ụbọchị.

Nnukwu ọbara ọgbụgba na-adịgide adịgide na-agụnye ị mgụ ọgwụ mg kwa ụbọchị ruo 15 ogologo oge.

Theakingụ ọgwụ maka ọrịa obi na-adịghị ala ala na-amalite na 2.5 mg kwa ụbọchị, ma mgbe ụbọchị 3-5 a na-amụba ya ruo 5 mg. Igo ndozi maka ọrịa a bụ 5-20 mg kwa ụbọchị.

Maka diphropathy na-arịa ọrịa mamịrị, Lisinopril na-atụ aro ị 10ụ 10 mg ka 20 mg kwa ụbọchị.

Ojiji nke nnukwu myocardial infarction gụnyere ọgwụgwọ siri ike ma a na-eme ya dị ka atụmatụ a: n'ụbọchị mbụ - 5 mg, mgbe ahụ otu ọgwụ otu ugboro kwa ụbọchị, mgbe nke ahụ nke ọgwụ ahụ na-amụba okpukpu abụọ ma na-ewere ya otu ugboro kwa ụbọchị abụọ, ọkwa ikpeazụ bụ 10 mg otu ugboro n'ụbọchị. Lisinopril, ihe ngosi na-ekpebi oge ọgwụgwọ, n'ihi na nnukwu myocardial infarction na-ewe opekata mpe isii.

Usoro onunu ogwu na nhazi

N'ime. Otu ugboro n'ụbọchị, n'agbanyeghị nri ị na-eri. N'ihe banyere ọbara mgbali elu akwara, ndị ọrịa na-anabataghị ọgwụ mgbochi ọgwụ ndị ọzọ ka etinyere 5 mg otu ugboro kwa ụbọchị, otu mmezi ahụ bụ 20 mg / ụbọchị. Oke kachasị kwa ụbọchị bụ 40 mg. Nsonaazụ zuru oke na-etolite mgbe izu abụọ na anọ gachara site na mbido ọgwụgwọ. Site na nsonaazụ ọgwụgwọ ezughi oke, ọgwụ a na ọgwụ ndị ọzọ antihypertensive nwere ike.

Ọ bụrụ na onye ọrịa ahụ natara ọgwụgwọ mbido site n’ọrịa diuretics, mgbe ahụ, a ga-akwụsị ị intụ ọgwụ ndị ahụ ụbọchị 2-3 tupu mmalite nke Lisinopril. Ọ bụrụ na nke a agaghị ekwe omume, mgbe ahụ ọgwụ izizi agaghị agafe 5 mg kwa ụbọchị. N'okwu a, mgbe ị takingụsịrị ọgwụ nke mbụ, a na-atụ aro ịlele ahụike maka ọtụtụ awa (a na-enweta nsonaazụ kachasị mgbe ihe dị ka awa 6), ebe ọ bụ na mbelata ọbara mgbali elu nwere ike ime.

Na nkụda obi na - adịghị ala ala - bido na 2.5 mg otu ugboro, ihe na - esote mmụba nke 2.5 mg mgbe ụbọchị 3 ruo 5 gasịrị. Oke kachasị kwa ụbọchị bụ 20 mg.

Nnukwu myocardial infarction (dịka akụkụ nke ọgwụgwọ njikọta n'ime awa iri abụọ na anọ mbụ na -echeta hemodynamics): na awa 24 mbụ - 5 mg, emesia 5 mg mgbe ụbọchị 1 gasịrị, 10 mg mgbe ụbọchị abụọ gachara 10 mg otu ugboro n'ụbọchị. Usoro ọgwụgwọ ya dịkarịa ala izu isii.

N'ime ndị agadi, a na-ahụkarị mmetụta hypotensive nwere ogologo oge, nke a na-esonye na mbelata lisinopril excretion (a na-atụ aro ịmalite ọgwụgwọ na 2.5 mg / ụbọchị).

Na ndị ọrịa nwere ọrụ ezughi oke ọrụ ka edobere ọgwụ a dabere na ụkpụrụ nke QC.

70 - 31 (ml / min) (serum creatinine)

Mmetụta akụkụ

Si usoro obi: mgbali ọbara na-ebelata, arrhythmias, mgbu obi, adịkarịghị - orthostatic hypotension, tachycardia.

Si ụjọ usoro: dizziness, isi ọwụwa, ike ọgwụgwụ, iro ụra, agbatị nke akwara nke aka na egbugbere ọnụ, adịkarịghị - asthenia, ịda mba, ọgba aghara, ehighị ụra nke ọma, vomiting.

Site na nri digestive: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, dyspepsia, agụụ belatara, mgbanwe uto, afọ mgbu, ọnụ.

Mmeghachi omume nfụkasị ahụ: angioedema (edema mpaghara nke anụ ahụ, anụ ahụ dị n'okpuru ala na / ma ọ bụ akpụkpọ anụ na njikọta urticaria ma ọ bụ na-enweghị ya), ọnya akpụkpọ ahụ, itching.

Ndị ọzọ: Ikwu "akpọnwụ", mbelata, adịkarịghị - ahụ ọkụ, ọzịza (ire, egbugbere ọnụ, aka).

Dodoụbiga ya ókè

Lọ nyocha ọfụma na njupụta nke lisinopril na mmadụ adịghị.

Enwere ike igosi mgbaàmà: hypotension akwara.

Ọgwụgwọ: Ekwesịrị inye onye ọrịa ahụ ọnọdụ kwụ ọtọ ma nwee ụkwụ etolite, ọ bụrụ na ọ dị mkpa, a na-agbanye saline intraven, a na-eme hemodialysis.

Mmekọrịta na ọgwụ ndị ọzọ

Mmanya na-egbu egbu, ihe ndị na-egbu egbu na ihe ndị ọzọ na-egbochi ọgwụ (ndị na-egbochi α- na β-adrenergic ndị na-anabata, ndị na-emegide calcium, wdg) na-eme ka mmetụta nke lisinopril pụta.

Ọgwụ antisteroidal anti-inflammatory ọgwụ, estrogens, adrenostimulants belata mmetụta hypotensive nke ọgwụ ahụ.

N'iji ọgwụ ndị na - eme ka a na - eme ya n'otu oge, belata mwepu nke potassium.

Mgbe ị na-eji ọgwụ ndị nwere lithium eme ihe, ọ ga-ekwe omume gbuo oge iwepụ lithium n'ahụ ya, n'ihi ya, mee ka ohere nke nsí ya dịkwuo elu. Ọ dị mkpa ịdị na-enyocha ọkwa lithium dị n'ọbara.

Ejikọtara ya na beta-blockers, ngwa mgbochi calcium na-egbochi ngwa ngwa, diuretics na ọgwụ ndị ọzọ antihypertensive na-abawanye ogo nke mmetụta hypotensive.

Antacids na colestyramine na -ebelata mwepu nke lisinopril na eriri afọ.

Njirimara ngwa

Iji kpachara anya, ekwesịrị iji Lisinopril mee ndị ọrịa nwere ọrịa akwara ozi ma ọ bụ ọrịa ụbụrụ iji gbochie ọnụ mbelata ọbara mgbali elu na ndị ọrịa.

Ejiri Lisinopril jiri nlezianya nye ndị ọrịa nwere akụrụngwa nsogbu gbasara akụrụ, mgbe a gbasasịrị akụrụ, ya na akwara akwara abụọ, akwara, mgbasa akụkụ ezighi ezi, ọrịa ụkwara ume ọkụ, na ndị ọzọ.

Ọbara mgbatị ọbara abụghị ihe a na-egbochi iji ọgwụ ọzọ n'ihu mgbe ọ kwụsịrị ọbara mgbali elu. Site na mbelata ọbara mgbali elu, ọ dị mkpa iji belata dose ahụ ma ọ bụ kwụsị ị Lụ Lisinopril ma ọ bụ diuretic.

N'ime ndị ọrịa nwere nnukwu nkụchi obi, iji ACE inhibitors nwere ike ibute nrụrụ akụrụ na-agbanwe agbanwe. N'ebe ụfọdụ ndị ọrịa nwere ọbara mgbali elu, yana yana stenosis akwara akwara abụọ ma ọ bụ akwara akwara, mmụba n'ọbara plasma urea na creatinine ga-ekwe omume.

N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala na ọbara mgbali nkịtị ma ọ bụ nke dị ala, ị ,ụ Lisinopril nwere ike ime ka mbelata ọbara mgbali elu, mana nke a abụghị ihe kpatara ịkwụsịtụ ọgwụgwọ.

Mgbe ị na-eme ọgwụ ịwa ahụ iji ọgwụ na-agwọ ọrịa hyestensive maka ọgwụ izizi, mwepu nke renin ga-ekwe omume. A na - ewepụ mgbakwunye ọbara nke na - ekesa ọbara n'ihi ọbara a na - egbochi ọbara.

Enwere ike mmepe nke hyperkalemia na ndị ọrịa nwere akụrụ akwara, ọrịa shuga mellitus, ọgwụgwọ concoitant na potassium-sparing diuretics (spironolactone, triamteren, amiloride) na potassium salts. Site na iji lisinopril jikọtara ọnụ na ọgwụ ọgwụ ndị dị n'elu, nyocha nlebara anya nke ịta potassium na ọbara n'ọbara dị mkpa.

Site na ịkwụsị ị takingụ ọgwụ Lisinopril na mberede, enweghi oke mmụba ọ bụla ma ọ bụ mmụba dị ukwuu na ọkwa ọbara ma e jiri ya tụnyere ọkwa ya tupu ị takingụ ọgwụ ahụ.

Anddị arụmọrụ na nchekwa nke Lisinopril nọọrọ onwe ya na ọgbọ onye ọrịa.

Ime na lactation

Lisinopril bụ contraindicated na ime na lactation (inye ara).

Ojiji nke ogwu n’oge nke II na nke ato nke ime nwere ike ime ka mbelata oke mmiri mmiri, ngosipụta nke ọrịa anuria, hypotension na mmebi nke ọkpụkpụ nke nwa ebu n'afọ.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ.

N'oge usoro ọgwụgwọ, mmadụ kwesịrị ịhapụ ịnya ụgbọ ala na ịme ihe omume ndị dị ize ndụ nke chọrọ ịta ahụhụ na ụba ọsọ nke mmeghachi omume psychomotor, dị ka ọgbụgba ga-ekwe omume, karịsịa na mmalite ọgwụgwọ.