Vozulim-N (Vozulim-N)

1 ml nke ọgwụ nwere:

ike ọrụ: insulin nke mmadu (inyocha mkpụrụ ndụ) 100 ME (4.00 mg),

ndị na-ebu ụzọ: protamine sulfate 0.40 mg, zinc oxide 0.032 mg, metacresol 1.60 mg, phenol 0.65 mg, glycerol 16.32 mg, sodium phosphate disubstituted anhydrous 2.08 mg, sodium hydroxide 0.40 mg, hydrochloric acid 0, 00072 ml, mmiri maka injection ruo 1 ml.

Nkwụsị na-acha ọcha, nke, mgbe ọ na-eguzo ọtọ, na-ekpughere ya n'ụzọ doro anya, enweghị agba ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-enweghị ọ andụ na mkpachapụ ọcha. A na - eji nwayọ nwayọ were weghachite ihe omume.

Mlọ ọgwụ

Izu oke nke nnabata na mmalite nke mmetụta nke insulin na-adabere n'ụzọ nke nchịkwa (subcutaneously, intramuscularly), ebe nchịkwa (afọ, apata ụkwụ, isi), dose (olu insulin insulin), itinye uche nke insulin na ọgwụ, wdg A na-ekesa ya n'ụzọ na-enweghị isi gafee akwara ma ghara ịgafe ihe mgbochi placental. na ara ara. Ọ bụ insulinase na-abụkarị imeju ya na akụrụ. Ọ bụ ya bụ akụrụ (30-80%).

Ime na lactation

Enweghị mgbochi ọ bụla maka ịgwọ ọrịa shuga mellitus na insulin n'oge afọ ime, ebe insulin anaghị agafe ihe mgbochi placental. Mgbe ị na-eme atụmatụ ịtụrụ ime na n’oge ya, ọ dị mkpa ime ka ọgwụgwọ shuga dị ike sie ike. Mkpa insulin na-agbadata n'oge ọnwa atọ nke mbụ nke afọ ime wee jiri nwayọ na nke abụọ na nke atọ.

N'oge na mgbe amuchara nwa, ihe ndi choro insulin nwere ike igbadata nke ukwuu. N'oge na-adịghị anya a mụsịrị nwa, mkpa ọ dị insulin na-alaghachi ngwa ngwa dị ka ọ dị tupu ime ime.

Enweghị mgbochi ọ bụla na ọgwụgwọ ọrịa shuga mellitus nwere insulin n'oge a na-enye nwa ara. Agbanyeghị, ọ nwere ike ịdị mkpa iji belata insulin, yabụ, iji nlezianya nyocha maka ọnwa ole ọ dị mkpa tupu ịkwado mkpa insulin dị.

Usoro ọgwụgwọ na nchịkwa Vozulim-N n'ụdị nkwusioru

Ezubere ọgwụ a maka nchịkwa okpuru ala.

Ọ bụ dọkịta na-ekpebi ọ̀tụ̀tụ̀ na oge nchịkwa nke ọgwụ ahụ n’otu n’okwu ọ bụla, dabere n’otú glucose dị n’ọbara. Na nkezi, kwa ụbọchị ọgwụ a sitere na 0,5 ruo 1 IU / kg body body (dabere na njirimara nke onye ọrịa na ịba ụba glucose ọbara).

Okpomoku nke mmanu insulin kwesiri ino na okpomoku.

A na-enyekarị ọgwụ a n'okpuru subcutaneously na apata ụkwụ. Enwere ike ịmekwa ya na mgbidi nke oghere ihu, ogwe ma ọ bụ ubu na ịkọwapụta akwara ahụ. Okwesiri igbanwe ebe ogwu ngbanyere na mpaghara anatomical iji gbochie mmepe nke lipodystrophy.

Enwere ike ijikwa Vozulim-N naanị otu ma ọ bụ na njikọta insulin nke na-adị mkpụmkpụ (Vozulim-P).

Jiri mkpịsị sirinji jiri naanị sirinji.

Ndị na-ahụ maka ọgwụ

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Aha ọgwụ dị mkpa yana ọgwụ ndị dị mkpa

Asambodo ndenye aha Vozulim-N

• LP-000323

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

Amachibidoro ịnyefe, detuo, kesaa ozi na enweghị ikike nke RLS-Patent LLC.
Mgbe ị na-ehota ihe ọmụma dị na peeji nke www.rlsnet.ru, njikọta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Nsonaazụ ọgwụ

N'ihi mmetụta nke metabolism metabolism: Ọnọdụ hypoglycemic (pallor nke anụ ahụ, ịba ụba ọsụsọ, palpitations, ịma jijiji, agụụ, mkpasu iwe, paresthesia nke mucosa aral, isi ọwụwa). Nnukwu hypoglycemia siri ike nwere ike iduga mmepe nke hypoglycemic coma.

Mmeghachi omume nfụkasị ahụ: ọnya ọnya, ọnya Quincke, nke dị ụkọ - ujo anafilactic.

Mmeghachi omume mpaghara: hyperemia, ọzịza na itching na ntụtụ ahụ, yana iji ogologo oge - lipodystrophy na saịtị ahụ.

Ndị ọzọ: ọzịza, njehie na-ezighi ezi (oge ụfọdụ na mmalite ọgwụgwọ).

Dodoụbiga ya ókè

Site na ịdoụbiga mmanya ókè, hypoglycemia nwere ike ịmalite.

Ọgwụgwọ: onye ọrịa ahụ nwere ike iwepụ hypoglycemia dị nwayọọ site na ị takingụ shuga ma ọ bụ nri nwere carbohydrate. Ya mere, a na-atụ aro ka ndị ọrịa nwere ọrịa shuga na-ebu shuga, swiiti, kuki ma ọ bụ ihe ọ fruitụ fruitụ mkpụrụ osisi dị ụtọ.

N'okwu ndị siri ike, mgbe onye ọrịa kwụsịrị ịmara, 40%, a na-edozi ihe ngwọta nke dextrose (glucose) intravenously, intramuscularly, subcutaneously, intravenously - glucagon. Mgbe ọ nwetasịrị onwe ya, a na-atụ aro onye ọrịa ka ọ rie nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Mmekorita

N ’ogwu ọgwụ ekwekọghị na ọgwụ nke ọgwụ ndị ọzọ.

E nwere ọtụtụ ọgwụ na-emetụta mkpa maka insulin.

A na - eme ka mmetụta hypoglycemic nke insulin dịkwuo elu nhọrọ beta-blockers, quinidine, quinine, chloroquine, monoamine oxidase inhibitors, angiotensin n'ịtụgharị enzyme inhibitors, carbonic anhydrase inhibitors, octreotide, bromocriptine, sulfonamides, anabolic Steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium, ọgwụ ọjọọ nwere ethanol.

Mmetụta hypoglycemic nke insulin na-ebelata glucagon, ibu hormone, estrogens, onu gbochie afọ, Steroid, iodinated thyroid homonụ, thiazide diuretics, loop diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, sulfinpyrazone, epinephrine, blockers nke H1-histamine ihe nnabata blockers "ngwa ngwa" calcium ọwa, diazoxide , morphine, phenytoin, nicotine.

Reserpine, salicylates nwere ike ịkwalite ma wedata ike hypoglycemic mmetụta nke insulin.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-ekpebi ọ̀hà na ụzọ nchịkwa nke Vosulima-R n’otu n’otu n’okwu nke ọ bụla dabere n’ihe glucose dị n’ọbara tupu nri na 1-2 awa mgbe nri, na-adaberekwa n’ókè ogo glucosuria na njiri mara nke ọrịa ahụ.

A na-elekọta ọgwụ ahụ s / c, na / m, na / n'ime, 15-30 nkeji tupu eri. Ofzọ kachasị na-elekọta Vosulima-R bụ s / c. Na ketoacidosis na-arịa ọrịa shuga, coma mamịrị, n’oge usoro ịwa ahụ - in / in na / m.

Site na monotherapy, oge nchịkwa na-abụkarị ugboro 3 kwa ụbọchị (ọ bụrụ na ọ dị mkpa, ruo ugboro 5-6 kwa ụbọchị), a na-agbanwe saịtị injection oge ọ bụla iji zere mmepe nke lipodystrophy (atrophy ma ọ bụ hypertrophy nke subcutaneous fat).

Nkezi ubochi ubochi bu 30-40 IU, na umuaka - 8 IU, mgbe ahu na otu ubochi obula - 0,5-1 IU / kg ma obu 30-40 IU 1-3 ugboro n ’ubochi, oburu na odi - ugboro 5-6 kwa ubochi. . N ’ọgwụ kwa ụbọchị karịrị 0.6 U / n'arọ, a ga-enye insulin ahụ n’ụdị ntụtụ 2 ma ọ bụ karịa na akụkụ dị iche iche nke ahụ. Ọ ga-ekwe omume ijikọta ya na insulins ndị na-eme ogologo oge.

A na-anakọta ihe ngosi Vozulima-R site na vial ahụ site na iji obere agịga na-egbu egbu na-ehichapu ọkpọkọ roba kpochapụrụ mgbe ọ wepụsịrị okpu alumọn.

Omume ọgwụ

Nnukwu insulin nke mmadụ na-eme n’onwe ya. Ọ bụ insulin nke oge ihe ji arụ ọrụ. Na -emezi usoro glucose, nwere mmetụta anabolic. Na akwara na akwara ndị ọzọ (ewezuga ụbụrụ), insulin na-eme ka glucose na amino acids nwee intracellular intracellular. Vosulim-P na-akwalite ntụgharị nke glucose na glycogen na imeju, na-egbochi gluconeogenesis ma na-akpali ntụgharị nke glucose ngafe na abụba.

Nsonaazụ

Site na usoro endocrine: hypoglycemia.

Nnukwu hypoglycemia nwere ike ibute ọnwụ na (n'ọnọdụ ụfọdụ) ọnwụ.

Mmeghachi omume nfụkasị: mmeghachi omume nfụkasị mpaghara enwere ike - hyperemia, ọzịza ma ọ bụ itching na saịtị ịgba ahụ (na - akwụsịkarị n'ime oge ọtụtụ ụbọchị ruo ọtụtụ izu), mmeghachi omume nfụkasị usoro (na - erughị oge, mana ọ ka njọ) - itching juputara, mkpụmkpụ ume, mkpụmkpụ ume , mgbada ọbara na-ebelata, obi mgbali elu, ịba ụba aja. Ọnọdụ siri ike nke mmeghachi omume nfụkasị systemic nwere ike igbu mmadụ.

Ntụziaka pụrụ iche

Ntugharị onye ọrịa na ụdị insulin ọzọ ma ọ bụ ịkwado insulin nwere aha azụmaahịa dị iche iche kwesịrị ịmalite n'okpuru nlekọta ahụike siri ike.

Mgbanwe na arụ ọrụ insulin, ụdị ya, ụdị (anụ ezi, insulin mmadụ, anaulin insulin) ma ọ bụ usoro mmepụta (insulin insulin ma ọ bụ insulin nke sitere anụmanụ) nwere ike ime ka edozigharị dose.

Enwere ike ịchọ mgbanwe mmezi nke Vosulima-R ugbua na nhazi mbụ nke nkwadebe insulin mmadụ mgbe ịkwado insulin anụmanụ ma ọ bụ jiri nwayọọ nwayọọ ruo ọtụtụ izu ma ọ bụ ọnwa mgbe nnyefe ahụ.

Mkpa insulin nwere ike wedata na arụmọrụ adrenal ezughi ezu, pituitary ma ọ bụ thyroid gland, yana akụrụ ma ọ bụ ịba ọcha n'anya.

Somenwe ọrịa ụfọdụ ma ọ bụ nrụgide mmetụta uche, ịchọrọ insulin nwere ike ịba ụba.

Ọ nwekwara ike ịdị mkpa iji dozigharị azụma mgbe ị na-emekwu ahụ ma ọ bụ mgbe ị na-agbanwe nri ị na-eri.

Leasedị mwepụta, nkwakọ ngwaahịa na ihe mejupụtara

Ngwọta maka ntụtụ.

3 ml - katọn (1) - ngwugwu na-acha uhie uhie (1) - ngwugwu nke kaadiboodu.
10 ml - karama iko (1) - igbe kaadiboodu.

Usoro usoro onunu ogwu

A na-ekpebi ogo na ụzọ nchịkwa nke ọgwụ ahụ n'otu n'otu n'ọnọdụ ọ bụla dabere na ọdịnaya glucose dị n'ọbara tupu iri nri na 1-2 awa mgbe ị risịrị nri, yana dabere na ogo glucosuria na njirimara nke usoro ọrịa ahụ.

Dịka iwu, a na-achịkwa s / c nkeji iri na abụọ tupu iri nri. A na-agbanwe saịtị ndị ịgba agba oge ọ bụla. Ọ bụrụ na ọ dị mkpa, a na-ahapụ nchịkwa IM ma ọ bụ nke IV.

Enwere ike ijikọ ya na insulins na-eme ogologo oge.

Mmetụta akụkụ

Mmeghachi omume nfụkasị: urticaria, angioedema, ahụ ọkụ, mkpụmkpụ ume, mbelata ọbara mgbali elu.

Site na usoro endocrine: hypoglycemia nwere ngosipụta dịka pallor, ịba ụba ọsụsọ, palpitations, ọgba aghara ụra, ịma jijiji, nsogbu akwara ozi, mmeghachi omume immunological na insulin mmadụ, mmụba na titer nke ọgwụ mgbochi insulin na mmụba na-esote glycemia.

Site n'akụkụ akụkụ ahụ nke ọhụụ: nkwarụ anya na-adịghị ala ala (ọ na-abụkarị mmalite nke usoro ọgwụgwọ).

Mmeghachi omume mpaghara: hyperemia, itching na lipodystrophy (atrophy ma ọ bụ hypertrophy nke abụba subcutaneous) na ntinye ahụ.

Ndị ọzọ: na mmalite ọgwụgwọ, edema ga-ekwe omume (ịgafe usoro ọgwụgwọ na-aga n'ihu).

Ime na lactation

N'oge afọ ime, ọ dị mkpa iburu n'uche mbelata mkpa nke insulin na ọkara nke mbụ ma ọ bụ mmụba nke ọnwa nke abụọ na nke atọ. N'oge na mgbe amuchara nwa, ihe ndi choro insulin nwere ike igbadata nke ukwuu.

N'oge a na-enye nwa ara, onye ọrịa chọrọ nleba anya kwa ụbọchị ruo ọtụtụ ọnwa (ruo mgbe ebilite mkpa nke insulin).

Mkparịta ụka ọgwụ ọjọọ

A na - eme ka mmetụta hypoglycemic dị na sulfonamides (gụnyere ọgwụ hypoglycemic nke ọgwụ, sulfonamides), MAO inhibitors (gụnyere furazolidone, procarbazine, selegiline), carbon anhydrase inhibitors, ACE inhibitors, ndị na - egbochi NSAIDs (gụnyere salicylides), anabolic (gụnyere stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, njikere lithium, pyridoxine, quinidine, quinine, chlo, etin, chlo, etin, chlo.

Glucagon, GCS, histamine H 1 na-anabata ihe mgbochi, mgbochi mkpịsị onwa, estrogens, thiazide na "loop" diuretics, mkpọchi calcium na-egbochi, ọmịiko, homonụ thyroid, tricyclic antidepressants, heparin, morphine diazropin belata mmetụta hypoglycemic mmetụta. , marijuana, nicotine, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine nwere ike ịkwalite ma belata mmetụta hypoglycemic nke insulin.

Ojiji nke beta-igbochi, clonidine, guanethidine ma ọ bụ reserpine nwere ike kpuchie mgbaàmà hypoglycemia.

N ’ogwu ọgwụ ekwekọghị na ọgwụ nke ọgwụ ndị ọzọ.

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Ọ bụ nkwụchi nke nchịkwa subcutaneous. 1 ml nke ngwakọta nwere insulin na-asọpụrụ mmadụ (70%) na insulin-isophan (30%) dị ka ihe ndị na-arụ ọrụ. Ọzọkwa, ihe mejupụtara ọgwụ ahụ gụnyere ihe enyemaka:

• mmiri maka ịgba ntụtụ - 1 ml,
• sodium phosphate (mmiri a na-akpọ mmiri) - 2.08 mg,
• protamine sulfate - 0.4 mg,
• glycerol - 16.32 mg,
• metacresol - 1.60 mg,
• zinc oxide - 0.032 mg,
• hydrochloric acid - 0,00072 ml,
• sodium hydroxide - 0.4 mg,
• phenol crystalline - 0.65 mg.

O bu osisa nye nsogbu n’enwe mgbe odi iche iche, mee ya ka odi n’ime ya. Mgbe ịma jijiji, laghachi na nkwụghachi

A na-etinye ọgwụ ahụ na karama ndị gbara ọkpụrụkpụ nke 10 ml, nke a na-etinye n'ime igbe kaadiboodu.

Ná nkezi - 1200 rubles.

Ntụziaka maka ojiji (usoro na usoro onunu ogwu)

Ebumnuche "Vozulim" bụ iwebata abụba dị n'okpuru ala. Ọ bụ dọkịta na-ahụ maka ịga ọrụ na-ekpebi usoro ị timeụ oge na oge eji ya dabere na ngosipụta nke glucose dị n'ọbara. Dịka ọ dị, ụkpụrụ ụbọchị dị iche site na 0,5 ruo 1 IU / kg dabere na njirimara nke onye ọrịa.

Okpomoku nke ulo nnabata ewebata kwesiri ibu okpomoku. Ebe nlekọta dị larịị bụ akwa dị n'okpuru apata ụkwụ. A na-anabata mpaghara n'ime akwara nke deltoid, a na-anabata mgbidi akụkụ na isi.

D IM MARA Achọrọ ịgbanwe saịtị ntụtụ iji oge ụfọdụ iji gbochie lipodystrophy.

A pụrụ ịgwọ ndị ọrịa na-arịa ụdị ọrịa shuga mellitus nke 2 na Vozulim na ọgwụ hypoglycemic ndị ọzọ (iji ọnụ), yana monotherapy.

Mmetụta ikike ịnya ụgbọ njem. .Bọchị na ajị anụ.

Na njikọta ebumnuche insulin, mgbanwe dị n'ụdị ya ma ọ bụ ọnụnọ nke nrụgide anụ ahụ ma ọ bụ nke uche, enwere ike belata ike ịkwọ ụgbọala ma ọ bụ ijikwa usoro dị iche iche, yana itinye aka na ihe omume ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume nke uche na moto.