A na-emepụta Atorvastatin-Teva n'ụdị mbadamba nkume ndị a kpuchiri ihe mkpuchi: ihe a kapịrị-acha odo odo, ọ fọrọ nke nta ka ọ bụrụ nke na-acha ọcha ma ọ bụ na-acha ọcha, nke a kpụrụ akpụ "93" n'otu akụkụ, na-etinye ihe na-adabere na akụkụ nke ọzọ: "7310" maka 10 mg, yana 7310 maka 20 mg "7311", maka 40 mg - "7312", maka 80 mg - "7313" (pcs 10. Na blisters, n'ime igbe kaadi nke 3 ma ọ bụ 9 blisters).

Ngwakọta 1 mbadamba:

• ihe na - arụ ọrụ: calcium atorvastatin - 10.36, 20.72, 41.44 ma ọ bụ 82.88 mg, nke ya na 10, 20, 40 ma ọ bụ 80 mg nke atorvastatin,
• ihe ndi ozo: povidone, lactose monohydrate, eudragit (E100) (methyl methacrylate, butyl methacrylate na dimethylaminoethyl methacrylate copolymer), sodium stearyl fumarate, croscarmellose sodium, alfa-tocopherol macrogol succinate,
• mkpuchi ihe nkiri: opadry YS-1R-7003 hypromellose 2910 3cP (E464), polysorbate 80, hypromellose 2910 5cP (E464), macrogol 400, titanium dioxide.

Ihe ngosi maka ojiji

• heterozygous ezinụlọ na hypercholesterolemia na-abụghị nke ezinụlọ, hypercholesterolemia, jikọtara (jikọtara) hyperlipidemia (ụdị IIa na IIb dịka nhazi nke Fredrickson) - yana nri nri na-eme ka ọ dị ala iji belata ogo dị elu nke cholesterol, obere lipoprotein cholesterol na Lilapropoin LL yana ịbawanye ụba nke lipoprotein cholesterol (HDL),
• Hyzycholesterolemia nke homozygous - iji belata kọlestrọl na LDL cholesterol, na enweghị ezigbo usoro ọgwụgwọ nri na usoro ọgwụgwọ ndị ọzọ,
• triglycerides dị elu nke ọbara (ụdị nke IV dịka nhazi nke Fredrickson) dysbetalipoproteinemia (ụdị III dịka nhazi nke Fredrickon) - ma ọ bụrụ na usoro ọgwụgwọ nri anaghị arụ ọrụ.

Ihe ngbanwe

• ime na lactation,
• afọ rue afọ 18 (amụbeghị profaịlụ nchekwa nchekwa nke atorvastatin na ụmụaka na ụmụaka),,
• ọrịa ọrịa imeju na-arụ ọrụ, mmụba na ọrụ nke enzymes imeju nke ihe a na-amaghị, karịa oke elu nke nkịtị (VGN) karịa ugboro atọ,
• mmebi imeju (classesmụaka Pugh na A na B),
• hypersensitivity na mmiri ọgwụ.

Ikwu (a choro iji mkpachapụ anya na ngwaahịa)

• endocrine na nsogbu nke metabolic,
• akpachaghị anya elektrik,
• hypotension akwara,
• akụkọ banyere ọrịa imeju,
• Akwụkwụ na-achịkwaghị achịkwa,
• nnukwu ọrịa na-efe efe (gụnyere sepsis),
• ọnya ọkpụkpụ
• mmerụ ahụ, nnukwu ịwa ahụ,
• mmanya riri ahụ.

Usoro onunu ogwu na nhazi

A na-eji ọnụ ekwu okwu Atorvastatin-Teva, oge 1 kwa ụbọchị. Iri nri anaghị emetụta arụmọrụ nke ọgwụ.

Usoro mbụ, dịka iwu, bụ 10 mg, a na-ewere mbadamba oge ọ bụla n'ụbọchị. Dika dọkịta hotara doses n’otu n’otu, dabere na ọkwa mbu nke cholesterol, ebumnuche ọgwụgwọ yana azịza onye ọrịa na usoro ọgwụgwọ. Bọchị kwa ụbọchị nwere ike ịdị iche site na 10 ruo 80 mg, ekwesịrị idozi ya na oge nke izu anọ ma ọ bụ karịa. Oke kachasị kwa ụbọchị ekwesịghị ịkarị 80 mg.

N'oge usoro ọgwụgwọ, na-abawanye na dose ahụ, a chọrọ ya kwa izu 2-4 ọ bụla iji nyochaa ọkwa nke plasma lipid ma, dabere na data enwetara, dozie dose ahụ.

Usoro a tụrụ aro:

• Hyzycholesterolemia homozygous ezinụlọ: 80 mg kwa ụbọchị,
• heterozygous familial hypercholesterolemia: na mmalite nke usoro ahụ, were 10 mg kwa ụbọchị, n'oge ọgwụgwọ kwa izu 4 a na-abawanye ọgwụ ahụ, na-ewetara 40 mg kwa ụbọchị, enwetara ya na usoro nke bile acid, mgbe ị na-eji atorvastatin dị ka ọgwụ monotherapy, enwere ike ịbawanye dose ahụ ruo na kachasịnụ ọgwụ. ụkpụrụ - 80 mg kwa ụbọchị,
• hypercholesterolemia nke mbu na agwakọta (jikọtara) hyperlipidemia: were 10 mg kwa ụbọchị, ọgwụ a n'ọtụtụ ndị ọrịa na-enye gị ohere ịnye njikwa achọrọ nke ọkwa lipid, dịka iwu, a na-ahụ mmetụta dị ukwuu ọgwụgwọ 4 izu mgbe mmalite nke nchịkwa ma dị ogologo oge iji ọgwụ ahụ.

Na ọnụnọ nke mmebi imeju, ọ bụrụ na ọ dị mkpa, enwere ike belata dose nke Atorvastatin-Teva ma ọ bụ kagbuo nnabata ya. Maka ndị ọrịa nwere ọrịa akụrụ, a chọghị ndozi dose.

Maka oria obi akwara na -akpo ma obu nnukwu nsogbu nke akwara obi, a na-atụ aro ka e jiri usoro mgbaru ọsọ ndị a maka mgbatị ọkwa: ngụkọta kọlọ ọnụego a

Ngwakọta na ụdị ntọhapụ

Dabere na ozi sitere radar nyere, Atorvastatin Teva bụ onye nnọchi anya ọgwụ ọgwụ ndị otu nke statins nwere. Ọgwụ nwere mmetụta kpọmkwem na enzyme reductase, nke ọ bụ ihe mgbochi. Ọgwụ ahụ dị n'ụdị mbadamba ụrọ, kpuchie ya na shei sitere na fim pụrụ iche, nke na-enye ngwaahịa ahụ ọcha na agba.

Ọrụ akụrụngwa arụmọrụ Atorvastatin Teva - Atorvastatin Calcium Trihydrate. Dabere na ntinye uche nke ihe na-arụ ọrụ, mkpụrụ ọgwụ nwere ọgwụ ọnụọgụ nke 21.7 ma ọ bụ 10.85 mg. Ọ bụrụ na ị na-agafeta na atorvastatin ọ bụ 20 na 10 mg, n'otu n'otu.

Na mgbakwunye na isi ihe na-arụ ọrụ ọgwụgwọ, mbadamba ihe ọ bụla nwere ụfọdụ ihe inyeaka. Ndị a gụnyere: kalsium carbonate, nsị opadray, magnesium stearate, cellulose, stachi. Onye rụpụtara ya ọgwụ a na ngwugwu na-acha ya na igbe kaadiboodu.

Nsonaazụ

Imirikiti ndị ọrịa na-anara ọgwụgwọ yana ntinye nke Atorvastatin-Teva, kwupụtara ezigbo nnabata ya. N'agbanyeghị nke a, dịka ọ bụla ọ bụla, ọgwụ a nwere ụfọdụ mmetụta. Site na ngwe nri ọrịa dyspeptik (afọ ọsịsa ma ọ bụ afọ ntachi, obi mgbu, ọgbụgbọ, ọgbụgbọ, belching), ntụpọ nke afọ na eriri afọ, ọrịa na-efe efe nke pancreas, afọ nwere ike ime.

Site na akụkụ mmegharị ahụ nwere ike ịmalite myositis, myalgia, arthralgia, myopathy, rhabdomyolysis. Atorvastatin na-akpata myopathy nwere ike ịdị mgbagwoju anya site na ọdịda akwara n'ihi myoglobinuria (mwepu nke ngwaahịa na-emebi emebi na mmamịrị).

Ọ dị ụkọ na ọgwụ na-akpata Ngosipụta nfụkasị (urticaria, ede ede Quincke, dermatitis, ọnya akpụkpọ ahụ erythematous).

Mgbe ụfọdụ enwere ike ọgụgụ isi, anụ ahụ ume, ụra na ịmụrụ anya, ihe ndapụta na ahụrụ anya

Ntụziaka maka ojiji

Tupu ịmalite iburu Atorvastatin Teva, na-enweghị ihe dị iche, ndị ọrịa niile chọrọ usoro hypocholesterol ọkọlọtọ. Ekwesịrị ịhụ ụkpụrụ a banyere ihe oriri na-edozi ahụ ọ bụghị naanị na ndabere nke ọgwụgwọ ọgwụ, kamakwa n'oge ndụ niile. Uzo a gha enyere aka imezu ebumnuche nke ogwu - LDL na cholesterol zuru oke gha aba uru ndi ozo, ogo nke HDL ga abawanye.

Enwere ike iwere Atorvastatin Teva n'agbanyeghị oge nri. Na ịmalite ọgwụgwọ, ịkwesịrị inyocha profaịlụ lipid kwa ọnwa iji họrọ ma mesịa dozie otu ọgwụ ahụ.

Usoro ịmalite amalite na-adịkarịghị 10 mg nke atorvastatin kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume iweta oke ọgwụ ruru 80 mg kwa ụbọchị, enwere ike kee ya abụọ (ụtụtụ na mgbede). Ọ bụrụ na a na-agwọ onye ọrịa n'otu oge ahụ na cyclosporiomas, usoro a na-eme kwa ụbọchị nke Atorvastatin Teva kwesịrị ịdị ntakịrị (10 mg kwa ụbọchị). A na-achọpụta mmụba nke mkpokọta atorvastatin na plasma ọbara (yana mgbakwunye na mgbanwe dị mma na ịdị mma nke na-ekesa ụmụ irighiri akwara) ụbọchị 10-14 mgbe mmalite nke ọgwụgwọ.

Jiri n’oge ime

Ime ime bụ ọnọdụ nke ahụ nwanyị ebe Atorvastatin Teva na - egbochi imebi iwu. Ojiji nke ogwu a ga-ekwe omume naanị mgbe abamuru nke nne karịrị ihe ize ndụ nke nwa a mụrụ amụ. N'ihi enweghi nyocha nyocha nke ụlọ ọgwụ gbasara ma Atorvastatin Teva gafere n'ime mmiri ara, amachibidoro ị itụ ya mgbe enwere ya nri. Ọ bụrụ na ọgwụgwọ na atorvastatin dị mkpa, a ga-akwụsị ịsa ahụ.

Ọ bụrụ na onye nnọchianya nke mmekọahụ dị mma nụrụ banyere afọ ime ya, na-amalitela ọgwụgwọ na Atorvastatin Teva, nnabata ya kwesịrị ịkwụsị ozugbo enwere ike. Iesmụ nwanyị na-a thisụ ọgwụ a ga-elekọta nke ọma nke a pụrụ ịdabere na ya iji chebe ịtụrụ ime nwata. Womenmụ nwanyị nke afọ omumu, tupu ịmalite ọgwụgwọ na Atorvastatin Teva, ọ bụ ihe amamihe dị na ya ịgakwuru onye ọkachamara n'ọrịa ụmụ nwanyị.

A naghị atụ aro iji Atorvastatin Teva maka otu mmadụ dị afọ ole na ole. Nke a bụ n'ihi eziokwu ahụ bụ na emebeghị nnwale na-adakarị ahụike na nchekwa nke ọgwụ na ụmụaka, yabụ na data ndị a adịghị.

Mmekọrịta na ọgwụ ndị ọzọ

Iji wepu mmetụta na-adịghị mma n'ahụ, ị ​​kwesịrị ịma etu Atorvastatin Teva si na ọgwụ ndị ọzọ na-emekọrịta. Iji otu oge eji ọgwụ ọjọọ eme ihe n’ime nwere norethisterone na ethinyl estradiol (ọgwụ mgbochi), ihe ụbara plasma nke ihe ndị a na - arụ ọrụ na - abawanye nke ukwuu. Ihe omumu a kwesiri iburu n'uche mgbe a na-edeputa mgbochi ime homonụ nke ụmụ nwanyị chọrọ ọgwụgwọ na Atorvastatin Teva.

A na - ahụta njikọta na - achọghị ka ya na atorvastatin na statins ndị ọzọ na cyclosporine, ọgwụ antimycotic, ụfọdụ ndị na - egbochi ọgwụ nje site na macrolide, na nicotinic acid. Iji ihe ndị a edochi anya na-abawanye ohere nke myopathy na nsogbu niile metụtara (rhabdomyolysis, ọdịda akụrụ).

Site na nhazi nke Atorvastatin Teva na digoxin n'otu oge, ntinye uche nke glycoside cardiac na plasma ọbara mụbara naanị mgbe ihe kwa ụbọchị nke statin bụ 80 mg. Ya mere, n'ime ndị ọrịa na-anata digoxin, iji zere ịlyụbiga mmanya glycoside, usoro nke onye na-eme ka mmanụ dị ala belata belata erughị 80 mg kwa ụbọchị.

Ọnụ ahịa ọgwụ ọjọọ

Mgbe ị na-azụ Atorvastatin Teva, ọnụahịa ahụ dabere na usoro nke ihe ahụ na-arụ ọrụ dị, yana netwọlọ ahịa ọgwụ ebe a na-eme atụmatụ ịzụta ọgwụ. Pricgwọ ọnụahịa maka ọgwụ a adịghị iche na ego ọgwụ ọjọọ yiri ya na ụkpụrụ ya.

• Na ókèala Njikọ Russia Ọnụ ego kwa otu nke Atorvastatin Teva bụ 200 rubles.
• Yukirenia ụlọ ahịa ọgwụ na-enye mbadamba 20 mg na ọnụahịa 250 UAH.

Atorvastatin-Teva analogs

Companieslọ ọrụ ọgwụ n'oge a na-enye ndị ahịa Atorvastatin Teva ọgwụ nke ma ụlọ ma ndị mba ọzọ. Ọgwụ ndị a dịgasị iche na aha azụmahịa, mana n'usoro nke ihe eji arụ ọrụ bụ ihe ha nhata. Ihe atụ ndị a na - ahụkarị Atorvastatin Teva bụ Atoris, Liprimar, Tulip, Torvakard, Atomax.

Nyocha Nyocha

Ọtụtụ nyocha ndị ọgwụ, nke ndị dọkịta na ndị ọrịa na-ekerịta, dị mma. Ndi mmadu nke buru Atorvastatin Teva kwuputara ezi nnabata ya, ihe na-adighi anya ngwa ngwa, nke e ji mara oge ya na oganihu ya. Ndị dọkịta na-ahụ maka ndị ọrịa na-anata Atorvastatin Teva, na-ekwu maka mmetụta dị mma a na-adakarị na ya, nke na-egosi na nsonaazụ nke ụzọ nyocha dị iche iche.

Atorvastatin Teva bụ ọgwụ nwere ike ịmịlata oke nke ahụ mmadụ, si otú ahụ chebe ya na nsị nke cholesterol na arịa nke akụkụ dị mkpa. Agbanyeghị, ndị ọrịa kwesịrị icheta na Atorvastatin Teva bụ ọgwụ bụ isi, nnabata nke a ga-ekwenye na dọkịta mgbe ha nyochachara nke ọma!

Mpempe usoro onunu ogwu

Mbadamba ụrọ, 10 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Otu mbadamba ihe

ihe na - arụ ọrụ - atorvastatin calcium trihydrate 10.3625 mg, 20.725 mg, 31.0875 mg, 41.450 mg, 62.175 mg, 82.900 mg, nke atorvastatin 10 mg, 20 mg, 30 mg, 40 mg, 60 mg 80 mg,

ndị na-ahụkarị: microcrystalline cellulose (GR M102), carbonate shydum anhydrous, maltose, croscarmellose sodium, magnesium stearate,

Ihe odide mkpuchi ihe nkiri: hypromellose (Pharmacoat Gr.606), hydroxypropyl cellulose, triethyl citrate, polysorbate 80, titanium dioxide (E 171).

A na-eji mbadamba nkume ndị ahụ mee ihe na-acha ọcha site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oval, na biconvex elu (maka onunu ogwu nke 10 mg, 20 mg, 40 mg, 80 mg).

A na-eji mbadamba nkume ndị ahụ mee ihe na-acha ọcha site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oval, na biconvex elu ya na akara "30" n'otu akụkụ (maka usoro nke 30 mg).

A na-eji mbadamba nkume ndị ahụ mee ihe na-acha ọcha site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha, oval, na biconvex elu yana akara "60" n'otu akụkụ (maka iji 60 mg).

Ngwongwo ogwu

Mgbe nchịkwa ọnụ gachara, a na-etinye atorvastatin ngwa ngwa. Ana enweta ntinye uche kachasị mgbe awa 1-2 gachara. N'ihi mgbochi nke dị na akpụkpọ ahụ mucous nke eriri afọ na nsonaazụ nke 'ụzọ mbụ' site na umeji, bioavailability zuru oke nke atorvastatin bụ 12%, na bioavailability usoro ahụ bụ 30%. Ogologo nha nke nkesa atorvastatin bụ ihe dịka 381 lita. Na-ejikọ ndị na-edozi plasma - 98%. Atorvastatin na-arụ ọrụ site na cytochrome P450 na ntinye nke ortho- na para-hydroxylated deri na ngwaahịa dị iche iche nke oxidation beta. Ihe mgbochi nke mgbochi HMG-CoA mbelata na plasma dị ihe dịka 70% n'ihi metabolites na-arụ ọrụ. Atorvastatin na metabolites ya bụ ọkachasịsịsịịị ihe banyere ya mgbe ọria hachara na ahụrụ ala. Ndụ ọkara nke atorvastatin bụ awa 14. Nkeji ọkara nke ndụ inhibitory nke HMG-CoA reductase bụ 20-30 awa n'ihi metabolites na-arụ ọrụ.

N'ime ndị ọrịa agadi, nsonaazụ nke atorvastatin na plasma dị elu.

N'ihe banyere ọrụ umeji na-arụ ọrụ, ịta atorvastatin na metabolites ya na-abawanye ugboro iri na isii.

Ejikọtara usoro nke ime ihe na mmebi nke cholesterol na imeju na ọkwa mevalonic acid n'ihi nhọrọ mgbochi nke HMG-CoA reductase. Atorvastatin na-ebelata plasma cholesterol na ọkwa lipoprotein n'ihi nsị cholesterol na imeju na mmụba na ọnụ ọgụgụ na ọrụ nke hepatic low density lipoprotein receptors (LDL) n'elu sel, nke na-eduga n'ịbawanye ụba na catabolism nke LDL. Atorvastatin dị irè na iwetulata ọkwa LDL na ndị ọrịa nwere hypercholesterolemia nke homozygous hereditary hypercholesterolemia bụ ndị na-anaghị azakarị ọgwụgwọ ọgwụgwọ belata oke. Mbelata nke ọkwa LDL na-ebelata ohere ịdị na-ebute ọrịa obi.

Usoro onunu ogwu na nhazi

Tupu ịmalite ọgwụgwọ, ị kwesịrị ịgbalị iji nweta nchịkwa nke hypercholesterolemia site na iji nri, mmega ahụ na oke ibu na ndị ọrịa nwere oke ibu, yana ọgwụgwọ nke ọrịa na-akpata.Mgbe ị na-ede ọgwụ ahụ, onye ọrịa ahụ kwesịrị ikwu ezigbo usoro hypocholesterolemic, nke ọ ga-agbaso n'oge ọgwụgwọ.

A na-a drugụ ọgwụ ahụ n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri a na-eri. A na-ahọrọ ọ̀gwụ nke ọgwụ ahụ site na 10 ruo 80 mg otu ugboro kwa ụbọchị, na-eburu n'uche ọdịnaya mbụ nke LDL-C, ebumnuche ọgwụgwọ na nsonaazụ otu onye. Na mmalite ọgwụgwọ na / ma ọ bụ n'oge mmụba nke ọgwụ ahụ, ọ dị mkpa iji nyochaa ọdịnaya ụrọ plasma kwa izu 2-4 ma dozie dose ahụ ma ọ bụrụ na ọ dị mkpa.

Hypercholesterolemia nke mbu na jikọtara ọnụ (jikọtara) hyperlipidemia: maka ọtụtụ ndị ọrịa - 10 mg otu ugboro kwa ụbọchị, mmetụta ọgwụgwọ na-egosipụta onwe ya n'ime izu abụọ ma na-ebutekarị izu n'ime izu anọ, na ọgwụgwọ ogologo, mmetụta ahụ na-adịgide.

Homozygous familial hypercholesterolemia: 80 mg otu ugboro kwa ụbọchị (n'ọtụtụ oge, ọgwụgwọ mere ka mbelata ọdịnaya LDL-C site na 18-45%).

Dyslipidemia siri ike: ọgwụ a na-atụ aro ka amalite bụ 10 mg otu ugboro n'ụbọchị. Enwere ike ịbawanye ọgwụ ahụ ruo mg mg 80 kwa ụbọchị dabere na nzaghachi na nnabata. A ga-ahọrọ doses n’otu n’otu n’iburu n'uche ebumnuche ọgwụgwọ.

Jiri na ndị ọrịa nwere ọrịa imeju: lee. "Ihe mgbochi."

Usoro onunu ogwu n’ime ndi oria na akwara itu: oria akaghi emetuta ntughari nke Atorvastatin-Teva na plasma ma obu ogo nke mbelata ihe LDL-C, ya mere, achoghi idozi uzo ogwu a.

Ngwa n’ime ndị agadi: enweghị ọdịiche na nchekwa, nrụpụta ọrụ, ma ọ bụ mmezu nke ebumnuche nke usoro ọgwụgwọ belata nke okenye n’etiti ndị agadi.

Atorvastatin-Teva - ngwa oru ohuru nke iwetulata cholesterol

Atorvastatin-Teva bụ ọgwụ na - enyere ndị ọrịa nwere cholesterol dị elu nke nwere nchekwa ichekwa na arịa ha. Nyocha ndị dọkịta na-ekwu na nke a bụ ọgbọ ọhụrụ nke ọgwụ, nke a na-enweta site na usoro.

Etu ị ga -esi nweta Atorvastatin-Teva cholesterol ọgwụ?

Ọgwụ a bụ nke otu statins, mana gosipụtara arụmọrụ dị elu karịa ọgwụ ndị yiri ya.

Njirimara nke Atorvastatin-Teva bụ oke mmachi na njikọta yana ọgwụ ndị ọzọ.

Ntụziaka maka iji ọgwụ maka cholesterol nwere ozi gbasara ngosipụta na atụmatụ nke ihe a. Edere otu ihe n'ụdị mbadamba nkume, mgbe kọlestrọl malitere inye ahụike nke onye ọrịa ahụ, na-akpalite mmepe nke ọtụtụ ọrịa. Edere mbadamba nkume Atorvastatin mgbe enwere ụdị ngosipụta a maka ojiji:

• ọrịa nke usoro akwara obi nke nwere ike ibute ọrịa sitere na mkpụrụ ndụ ihe nketa na afọ, ndụ adịghị mma, ị alcoholụ mmanya na-ese anwụrụ,
• ọbara mgbali elu
• infarction myocardial na ọrịa strok,
• imegharị ụlọ ọgwụ nke angina pectoris kpatara,
• hypercholesterolemia isi na eketa eketa,
• mkpa ịgbakwunye nri nri pụrụ iche edepụtara maka hyperlipidemia, dysbetalinoproteinemia, hypertriglyceridemia.

Cholesterol n’ime ọrịa ndị ahụ na-etinye mmadụ ụjọ, na-eme ka ohere nke ọnwụ mberede si na nsogbu pụta. Ofzọ nke ọgwụ a chọrọ iji gbochie ihe dị ka HMG-CoA reductase, na-atụgharị akụkụ ya 3-hydroxy-3-methylglutarin-CoA ka ọ bụrụ mevalonic acid. N'ihi ya, mkpụrụ ndụ ihe dị ala na-amalite na-etolite, nke na-enyere aka belata ihe ize ndụ nke ibute ọrịa obi, atherosclerosis, ma belata ego cholesterol na mgbidi arịa ọbara.

Nsonaazụ

Ọtụtụ mgbe (> 1/100 ruo ˂1 / 10)

- ihe mgbu na ogwugwu na pharynx, imi

- flatulence, dyspepsia, ọgbụgbọ, afọ ọsịsa, afọ ntachi

- myalgia, ogbu na nkwonkwo, ihe mgbu na ukwu, akwara mgbu, nkwonkwo na-emegharị, mgbu azụ.

- mgbanwe na-egosi ọrụ nke imeju, mmụba na ọkwa nke creatine phosphokinase (CPK) n'ọbara (ọkwa nke mmụba na creatine phosphokinase karịa ugboro atọ karịa oke elu nke ụkpụrụ) ka a chọpụtara na 2.5% nke ndị ọrịa na-ewere atorvastatin na ugboro iri karịa nke elu nke ụkpụrụ 0.4% nke ndị ọrịa)

Oge ụfọdụ (> 1/1000 ruo ˂1 / 100)

- ura abalị, ura

- dizziness, paresthesia, hypesthesia, dysgeusia

- vomiting, mgbu nke afọ, belching

- olu mgbu, olu ike

- urticaria, ọnya ọnya, itching, alopecia

- malaise, asthenia, mgbu obi, oke ọgụ, ike ọgwụgwụ, ahụ ọkụ

- nsonaazụ dị mma maka ọnụnọ sel ọbara ọcha na mmamịrị

- mụbara ọkwa nke transaminases. Obere na-agbanwe, na-agafe agafeghị achọ ọgwụgwọ. Ahụike dị mkpa (ugboro atọ karịa nke elu karịa nke nkịtị) abawanye na ọbara ọbara na-achọpụta na 0.8% nke ndị ọrịa na-anata atorvastatin. Mmụba a bụ ọgwụ dabere ma tụgharịa ya na ndị ọrịa niile.

Oge na-adịghị anya (> 1/10000 ruo ˂1 / 1000)

- Quincke edema, oke ụjọ dermatitis, Stevens-Johnson syndrome, necrolysis na-egbu egbu, erythema multiforme

- myopathy, myositis, rhabdomyolysis, tendinopathy, tendon rupture

- iwelie n’arụ ahụ

Ọ dị ụkọ (> 1/10000 ruo ˂1 / 1000)

- ichefu, nchefu ihe, amnesia, ọgba aghara

A kọọrọ mmeghachi omume ọjọọ ndị a, ugboro ole nke edobeghị

- ọrịa ngụgụ (ọrịa ogologo oge)

- ọrịa shuga mellitus, ugboro ole dabere na ọnụnọ ma ọ bụ enweghị ihe ndị dị ize ndụ (glucose ọbara na-ebu ọnụ> 5.6 mmol / l, BMI> 30 n'arọ / m2, triglycerides dị elu, akụkọ ihe mere eme nke ọbara mgbali)

- Immuno-onye ogbugbo necrotizing myopathy

Mkparịta ụka ọgwụ ọjọọ

Mmetụta ọgwụ na atorvastatin

Atorvastatin bụ metabolized na ntinye nke cytochrome P450 3A4 (CYP3A4) ma bụrụ mkpụrụ maka mbughari nke protein, dịka ọmụmaatụ, onye na-ebugharị nnabata ịba ọcha n'anya OATP1B1. N'otu oge eji ọgwụ ọjọọ eme ihe bụ ndị na - egbochi CYP3A4 ma ọ bụ ihe na - ebugharị protein nwere ike ime ka plasma nke mkpokọta atorvastatin ma nwekwuo ohere myopathy. Ihe ize ndụ ahụ nwekwara ike ịbawanye elu site n'iji atorvastatin na-eme n'otu oge yana ọgwụ ndị ọzọ nwere ike ibute myopathy, dịka ọmụmaatụ, usoro nke fibroic acid na ezetimibe.

A na-ahụ ihe mgbochi CYP 3A4 dị ike na-eduga na mmụba dị ukwuu na mkpokọta atorvastatin. Mgbe ọ bụla o kwere omume, iji otu ihe na-egbochi CYP 3A4 inhibitors (dịka ọmụmaatụ, ya na cyclosporine, telithromycin, clarithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole na opekata mịnịsta HIV na-egbochi ndị na-egbochi ya, gụnyere ritonavir lacaina, kameanavirina la, beenaina, ya na ndị na-achọghị ya, belata ya bụ, na-achọghị ya, belata ya na-achọghị ya, belata ya bụ na o kwesịrị ka a kwụsị ya, ya bụ, ka na-achọghị ya. na ndi ozo). Ọ bụrụ na ọ gaghị ekwe omume izere otu oge iji ọgwụ ndị a na atorvastatin, ị kwesịrị ịtụle ị atụ atorvastatin na oke kachasị dị mma, a na-atụkwa aro ileba anya na ọnọdụ onye ọrịa ahụ.

Inhibitors CYP 3A4 na-agbanwe agbanwe (dịka ọmụmaatụ, erythromycin, diltiazem, verapamil na fluconazole) nwere ike ịbawanye ọkwa plasma nke atorvastatin. Ojiji erythromycin na statins na-ejikọkarị ohere nke myopathy. Emebeghị nnyocha banyere mmekọrịta nke ọgwụ iji chọpụta ihe amiodarone ma ọ bụ verapamil na atorvastatin. A maara na amiodarone na verapamil na-egbochi ọrụ CYP 3A4, yabụ, nchịkwa nke oge ọgwụ ndị a na atorvastatin nwere ike iduga nsonaazụ nke atorvastatin. Ya mere, site na iji onorvastatin na-agafe agafe na inyocha ọnya CYP 3A4 na-agafeghị oke, ekwesịrị ịtụle ọgwụ atorvastatin dị ala, a na-atụkwa anya ileba anya na onye ọrịa. Mgbe ibidochara onye na-egbochi ya ma ọ bụ mgbe ọ dozigharịrị ọnya ya, a na-atụ aro ileba anya nke ọma.

Ihe ọ juiceụụ mkpụrụ osisi grape nwere otu ma ọ bụ karịa ihe na-egbochi cytochrome CYP 3A4 ma nwee ike ịbawanye ụba nke plasma nke atorvstatin, ọkachasị na ị excessiveụbiga mmanya oke (> 1.2 lita kwa ụbọchị).

Inductors CYP 3A4

Oge nchịkwa nke atorvastatin nwere cytochrome P450 3A4 inducers (dịka ọmụmaatụ, yana efavirenz, rifampicin, St John's wort) nwere ike itinye aka na mbelata nke na-adịghịzi ike na mkpụkọ plasma nke atorvastatin. N'ihi usoro nke okpukpo abụọ nke rifampicin (mkpali nke cytochrome P450 3A na mgbochi nke onye na-ebugharị hepatic OATP1B1), a na-atụ aro nchịkwa nke atorvastatin na rifampicin, ebe ọ bụ na ị na-atorvastatin ogologo oge mgbe mgbakwunye rifampicin nwere nnukwu mbelata nke plasma na mkpo ya. Agbanyeghị, nsonaazụ nke rifampicin na mkpokọta nke atorvastatin na mkpụrụ ndụ akwara amabeghị, ọ bụrụ na ọ gaghị ekwe omume izere otu oge, a ga-elezi anya nyocha nke ịdị nke onye ọrịa.

Ndị na-egbochi protein

Ndị na-egbochi nchebe ụgbọ (dịka ọmụmaatụ, cyclosporine) na-enwe ike ịkwalite mmetụta usoro atorvastatin. Amabeghị nsonye nke vetikal nke ịba ọcha n'anya nke mkpokọ atorvastatin n'ime mkpụrụ ndụ akwara. Ọ bụrụ na ọ gaghị ekwe omume izere otu oge nchịkwa ọgwụ ndị a, a na-atụ aro ka ibelata ọnụọgụ ma duzie nlezianya banyere ịdị irè.

Gemfibrozil / Ntọpụta Ihe Nkịtị Acid / Ezetimibe

Ojiji nke fibrates na ezetimibe dị ka monotherapy jikọtara ya na mmepe nke ihe ịtụnanya sitere na usoro akwara, gụnyere rhabdomyolysis. Iji otu oge ezetimibe ma ọ bụ ihe ndị na-emepụta fibric acid na atorvastatin, ohere nke ịmalite ihe ịtụnanya ndị a nwere ike ịba ụba. Ọ bụrụ na ọ gaghị ekwe omume izere otu oge nchịkwa ọgwụ ndị a, ọ dị mkpa iji obere atorvastatin dịkarịa ala iji nweta ebumnuche ọgwụgwọ, yana nlebara anya nke ndị ọrịa.

Ntinye uche nke atorvastatin na metabolites ya na-arụ ọrụ na plasma ọbara dị ala (ihe dịka 25%) mgbe ị na-ewere kọlestrọsh nke atorvastatin. N'otu oge ahụ, mmetụta nke egbugbere ọnụ nke ngwakọta nke ọgwụ actorvastatin na colestipol gafere mmetụta nke na-enye ọgwụ ndị a n'otu n'otu.

Emebeghị nnyocha banyere mmekọrịta nke atorvastatin na fusidic acid. Enweela akụkọ banyere akwara ndị sitere na uru ahụ, gụnyere rhabdomyolysis, mgbe ha na-a atụ atorvastatin na fusidic acid. Amaghị usoro nke mmekorita a. Ekwesighi iji ọgwụ Atorvastatin na fusidic acid. Ọ bụrụ na ọ dị mkpa iji systemic fusidic acid, a ga-akwụsị ọgwụgwọ na statins maka oge ọgwụgwọ niile na fusidic acid. A gwara ndị ọrịa ka ha gaa hụ dọkịta ozugbo ọ bụrụ na ha enwee mgbaàmà ọ bụla nke ike ọgwụgwụ, ihe mgbu, ma ọ bụ ọnya.

Enwere ike ịmalite ọgwụgwọ Statin ugboro asaa ka ụbọchị ikpeazụ nke fusidic acid gasịrị. N'ọnọdụ ndị pụrụ iche, mgbe achọrọ sistemu nke fusidic acid ruo ogologo oge, dịka ọmụmaatụ, maka ọgwụgwọ nke ọrịa na-efe efe, ekwesịrị ịtụle nkwonkwo nke atorvastatin na fusidic acid n'otu n'otu yana aga-eme ọgwụgwọ n'okpuru nlekọta ahụike dị nso.

Ọ bụ ezie na emebeghị nnyocha banyere njikọta nke atorvastatin na colchicine, a kọwowo ihe banyere myopathy site na iji atorvastatin na colchicine, na ekwesịrị iji akpachara anya atorvastatin na colchicine.

Nsonaazụ nke atorvastatin na ọgwụ eji eme ihe

Site n'iji 10 mg nke digoxin na atorvastatin na-eme n'otu oge, nha anya nke digoxin na-abawanye ntakịrị. Ndị ọrịa na-a digụ digoxin chọrọ nleba anya kwesịrị ekwesị.

Ojiji nke atorvastatin na ọgwụ mgbochi onụ na-eme ka ọnụnọ nke northindrone na ethinyl estradiol.

E kwesịrị ịtụle nsonaazụ a mgbe ị na-ahọrọ ọgwụ mgbochi ọgwụ na nwanyị na-ewere atorvastatin.

Ọ bụ ezie na ọ bụ naanị obere ikpe gbasara mmekọrịta mmekọrịta na anticoagulants ka a kọrọ, n'ime ndị ọrịa na-ewere ọgwụ anumọgulants, a ga-ekpebi oge prothrombin tupu ịmalite ọgwụgwọ na atorvastatin ma nwee oge zuru ezu na usoro ọgwụgwọ iji hụ na enweghị mgbanwe mgbanwe dị ukwuu na oge prothrombin. Ozugbo edere oge prothrombin kwụsiri ike, enwere ike inyocha ya ugboro ole a na-atụkarị aro ka ndị ọrịa na-anata ọgwụ anumọgulants. Ekwesiri imeghachi otu usoro ahụ mgbe ị na-agbanwe dose nke atorvastatin ma ọ bụ kagbuo ya. Atorvastatin adịghị esochi usoro ikpe ọbara ọgbụgba ma ọ bụ mgbanwe n'oge prothrombin na ndị ọrịa na-anaghị anticoagulants.

Antacids nwere magnesium ma ọ bụ aluminom hydroxide

Site na ojiji nke antacids n'otu oge nwere magnesium ma ọ bụ aluminom hydroxide na atorvastatin, ịta nke ikpeazụ na plasma ọbara na-ebelata.

Ntụziaka pụrụ iche

Ọkpụkpụ akpụ akpụ akpụ

Atorvastatin, dị ka HMG-CoA reductase inhibitors ndị ọzọ (hydroxymethylglutaryl coenzyme A reductase), nwere ike imetụta akwara ọkpụkpụ ma mee ka myalgia, myositis, na myopathy, nke nwere ike ịga n'ihu rhabdomyolysis, ọnọdụ na-eyi ndụ egwu nke e ji ọkwa dị elu nke creatine kinase mara nke ọma. (QC) (> 10 ugboro VPN), myoglobinemia na myoglobinuria, nke nwere ike ibute ọdịda akwara. Ọrịa nkwarụ gbasara ọrịa gbasara akụrụ nwekwara ike ịbụ ihe egwu dị ka ọrịa rhabdomyolysis. Site na iji atorvastatin jikọtara ọnụ na ọtụtụ ọgwụ, dị ka cyclosporine na nwere ike CYP 3A4 inhibitors (clarithromycin, intraconazole, nje inhibitors HIV), a na-enwekwu ihe ize ndụ nke ịmalite myopathy / rhabdomyolysis.

Inye Atorvastatin-Teva a lipid-ẹsụhọde doses na Nchikota na a fibric acid nkwekọrịta, erythromycin, cyclosporin, Teli-tromitsinom, immunosuppressants, n'ịgwa nke HIV protease inhibitors (saquinavir, ritonavir, lopinavir na ritonavir, tipranavir, ritonavir, darunavir na ritonavir, fosamprenavir na ritonavir) , na niacin, ọgwụ aerosol antifungal ma ọ bụ nicotinic acid, yana yana colchicine, dọkịta kwesịrị iji nlezianya tụlee uru a na-atụ anya ya na ihe egwu dị na ọgwụgwọ a ma na-ahụ ihe mgbu mgbe niile. s ịchọpụta ihe mgbu ma ọ bụ adịghị ike na uru, karịsịa n'oge mbụ ọnwa ole na ole nke ọgwụgwọ na n'oge na-amụba doses nke ọ bụla Nwa na njikọ na ihe ize ndụ nke myopathy. Mgbe ejikọtara ya na ọgwụ ndị a dị n'elu, a ga-atụle ohere nke iji obere mbido mbụ na mmezi nke atorvastatin. N'ọnọdụ ndị dị otú ahụ, enwere ike ịkwado mkpebi nke oge ọrụ nke CPK, ọ bụ ezie na nlele dị otú ahụ anaghị egbochi mmepe nke myopathy siri ike.

Achịkọtara maka ịhọpụta ihe ndị na - emekọrịta ihe na tebụl dị n'okpuru ebe a.

Mkparịta ụka ọgwụ ọjọọ na-ejikọ ya na oke ihe egwu nke myopathy / rhabdomyolysis

Ndụmọdụ maka oge atọrọ

Cyclosporin, nje na-egbochi nje HIV (tipranavir with ritonavir), ọrịa ịba ọcha n'anya C (protela inhibitor (telaprevir), fusidic acid

Zere iji atorvastatin

Ihe mgbochi nje HIV (lopinavir na ritonavir)

Jiri nlezianya mee ma n ’ụzọ kacha nta achọrọ.

Clarithromycin, intraconazole, nje na-egbochi nje HIV (saquinavir nwere ritonavir *, darunavir nwere ritonavir, fosamprenavir, fosamprenavir with ritonavir)

Eferela ọgwụ onorvastatin

Ihe na-egbochi nje HIV (nelfinavir), ịba ọcha n'anya nke nje virus nke C (boceprevir)

Kariri ogo atorvastatin 40 mg kwa ụbọchị

* Jiri mkpachapụ anya na iji nwayọ kachasị ala achọrọ.

Ejiri Atorvastatin-Teva jiri nlezianya nye ndị ọrịa nwere ihe ga-ebute rhabdomyolysis na mmepe nke nnukwu akụrụ ọdịda n'ihi myoglobinuria na myoglobinemia (hypothyroidism, ọrịa akwara ụkwụ, ọrịa akụrụ, akụkọ ihe mere eme nke ọrịa imeju, iji ọtụtụ ihe na-egbu egbu na-egbu egbu ị ,ụ mmanya), uru ahụ. akụkọ ihe mere eme nke statins ma ọ bụ fibrates, onye ọrịa ahụ karịrị afọ 70). N'okwu a, ọ dị mkpa ịmụ ọkwa nke creatine phosphokinase (KFK), ma ọ bụrụ na ọkwa KFK gafere ugboro ise, ekwesighi ịmalite ọgwụgwọ. N'oge ọgwụgwọ, ọ bụrụ na enwere mkpesa nke mgbu akwara, mgbu, adịghị ike, ịba, na ahụ ọkụ, ọ dị mkpa iji chọpụta ọkwa nke KFK, ọ bụrụkwa na KFK gafere oge ise, nwa oge ma ọ bụ kwụsị kpamkpam iji atorvastatin.

A ga-adọ ndị ọrịa e kenyere na Atorvastatin-Teva aka na ntị ka ha gakwuru dọkịta ozugbo ma ọ bụrụ na mgbu na-enweghị isi ma ọ bụ adịghị ike ahụ na-enweghị isi, ọkachasị ma ọ bụrụ na ọnya na ahụ ọnya so ya.

Imeju na imeju

Ka emechara ya na atorvastatin, ihe di omimi (ihe kariri ugboro 3 ma e jiri ya tụnyere ogo nke ụkpụrụ dị elu) kwuru na mmụba nke ọbara ọgbụgba nke "imeju".

Ọ dị mkpa ileba anya n'ihe ngosipụta nke ọrụ umeji n'oge usoro ọgwụgwọ niile, ọkachasị mgbe akara ngosipụta nke mmebi imeju pụtara. N'ihe banyere mmụba nke ọdịnaya hepatic transaminases, a ga-enyocha ọrụ ha ruo mgbe a ruru oke ụkpụrụ. Ọ bụrụ na mmụba na ọrụ AST ma ọ bụ nke ALT ihe karịrị ugboro 3 ma e jiri ya tụnyere oke nke ụkpụrụ ahụ ka ana-echekwa, a na-atụ aro ka ọ belata ma ọ bụ kagbuo dose ahụ.

Ndị ọrịa na-a Atụ Atorvastatin-Teva kwesịrị izere ị alcoholụ mmanya. Jiri ịkpachara anya na ndị ọrịa na-a abuseụbiga mmanya ókè na / ma ọ bụ na-arịa ọrịa imeju (akụkọ ihe mere eme).

Mgbochi Ọrịa Site na Mwepu cholesterol mkparị (SPARCL) / Ọbara ọbara

N'ime ndị ọrịa nwere akụkọ banyere ọbara ọgbụgba n'ọbara ma ọ bụ infarction, ego adịghị ekpebi ihe egwu / uru nke atorvastatin na dose nke 80 mg, yabụ, ojiji nke Atorvastatin-Teva na ndị ọrịa dị otú ahụ ga - ekwe omume naanị mgbe ọ kpebiri ikpebi ihe ize ndụ / uru, Tụlee ihe nwere ike ibute ọrịa ọbara ọgbụgba ugboro ugboro.

Necrotic Myopathy na-ahụ maka mgbasa ozi (IONM)

N'okwu ndị na-adịghị ahụkebe, n'oge ọgwụgwọ ma ọ bụ mgbe ejiri ụdị ụfọdụ nke statins, immuno-mediated necrotic myopathy (IONM). IONM na-amata ahụike na ịnọgidesi ike ike yana ịba ụba yana ịba ụba serum creatine kinase, nke na-adịgide ọbụlagodi mgbe a kwụsịrị ọgwụgwọ na akpụ akpụ. N'ọnọdụ mgbe ọgwụgwọ atorvastatin chọrọ ọgwụgwọ ọgwụgwọ na ọgwụ ndị a, ọ dị mkpa iji nlezianya mụọ ihe egwu / uru dị na ọgwụgwọ jikọtara.

Ọrịa ngụgụ

Ekebeghi ihe di iche n’onye oria n’akwara nwoke bu oria na udiri oria, karia oge obula. Ọ bụrụ na n'oge ọgwụgwọ, enwere ihe mgbaàmà nke mmepe nke ọrịa pulmonary interstitial (mkpụmkpụ ume, ụkwara na-enweghị mkpụrụ, ike ọgwụgwụ, oke ibu, ahụ ọkụ), ekwesịrị ịkwụsị ọgwụ statin.

Statins na-abawanye glucose ọbara, na n’ọrịa ụfọdụ ndị nwere nnukwu nsogbu ibute ọrịa shuga n’ọdịniihu, ha nwere ike ibute hyperglycemia, ebe ọ bụ ihe amamihe dị na ya ịmalite ọgwụgwọ maka ọrịa shuga. Agbanyeghị, ihe egwu a ga - akarị uru nke iwelata ihe ize ndụ na akwara ọbara na akpụ, yabụ ekwesịghị ịbụ ihe kpatara iji kwụsị ọgwụgwọ statin. Ndị ọrịa nọ n'ihe ize ndụ (glucose na-ebu ọnụ nke 5.6-6.9 mmol / L, BMI> 30 n'arọ / m2, triglycerides dị elu, ọbara mgbali elu) na-ewere akpụ a ga-enyocha nyocha na nyocha nke biochemical.

Ekwesighi iji atorvastatin na fusidic acid mee ihe n'otu oge, yabụ, ọ dị mkpa ịtụle ohere nkwụsị nke atorvastatin nwa oge n'oge ọgwụgwọ na fusidic acid.

Okwesiri iburu n’uche na mgbe ị na-ewere Atorvastatin-Teva na mmiri mkpụrụ osisi grape, nsonaazụ nke atorvastatin na plasma na-abawanye na ọghọm nke mmetụta ndị ọzọ na-amalite.

Ojiji ụmụaka

N'ime ụmụaka na-erubeghị afọ 18, etoliteghị ịdị irè na nchekwa n'ihi ahụmịhe bara uru na iji ya.

Akụkụ nke nsonaazụ ọgwụ ahụ nwere ike ịnya ụgbọ ma ọ bụ usoro nwere ike ibute

N'inye mmetụta nke ọgwụ ahụ, akpachara anya kwesịrị igosipụta mgbe ị na-anya ụgbọ na ụzọ ndị ọzọ nwere ike ịdị ize ndụ.

Mwepụta wepụtara na nkwakọ

Mpempe akwụkwọ 10 na mbadamba ngwungwu Alu / Alu, nke nwere ihe nkiri polyvinyl chloride ma ọ bụ polyvinylidene chloride na fodili nke alvin nke dị na ya na ihe nkiri polyvinyl chloride polyamide na foil aluminom.

Mkpokọta sel atọ 3 yana ntuziaka maka ojiji ahụike na steeti na asụsụ Russian ka etinye na ngwugwu kaadiboodu.

Atorvastatin-Teva ọgwụ: ntuziaka, contraindications, analogues

Atorvastatin-Teva bụ ọgwụ hypoliplera. Usoro nke ị actionụ ọgwụ belata belata belata cholesterol “ọjọọ” yana oke nke triglycerides na lipoproteins dị ala. N'aka nke ha, ha na-abawanye ịba ụba nke lipoproteins dị elu yana cholesterol dị mma.

Atorvastatin-Teva dị n'ụdị nke mbadamba ihe mkpuchi fim. Edere ihe odide abụọ na elu ha, otu n'ime ha bụ "93", nke abụọ dabere na usoro ị drugụ ọgwụ ahụ. Ọ bụrụ na usoro onunu ogwu di 10 mg, yabụ edetu ederede "7310", ma ọ bụrụ na 20 mg, mgbe ahụ "7311", ọ bụrụ 30 mg, mgbe ahụ "7312", ma ọ bụrụ 40 mg, mgbe ahụ "7313".

Ngwakọta bụ isi nke Atorvastatin-Teva bụ calcium atorvastatin. Ọzọkwa, ihe mejupụtara ọgwụ ahụ gụnyere ọtụtụ ihe ndị ọzọ, ihe inyeaka. Ndị a gụnyere, dịka ọmụmaatụ, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.

Usoro nke Atorvastatin-Teva

Atorvastatin-Teva, dị ka anyị kwuburu na mbido, bụ ihe nnọchianya na-egbusi ike. Ike ya niile bụ iji gbochie, ya bụ, igbochi ọrụ enzyme n'okpuru aha HMG-CoA reductase.

Ọrụ bụ isi nke enzyme a bụ ịhazi nguzobe nke cholesterol, ebe ọ bụ na e guzobere ya, mevalonate, site na 3-hydroxy-3-methyl-glutaryl-coenzyme A. buru ụzọ. A na-eziga cholesterol ahụ, yana triglycerides, na imeju, ebe ọ na-ejikọ ọnụ na obere lipoprote dị ntakịrị. . Akụrụngwa kpụpụtara na-abanye na plasma ọbara, ma were nke ugbu a nyefe akụkụ ahụ na anụ ahụ ndị ọzọ.

A na-agbanwe lipoproteins dịkarịsịrị ala dị ntakịrị site na ịkpọtụrụ ndị na-anabata ha. N'ihi mmekorita a, ha catabolism, i.e., ire ere, na-apụta.

Ọgwụ na-ebelata oke cholesterol na lipoproteins n'ọbara nke ndị ọrịa, na-egbochi mmetụta nke enzyme ma na-abawanye ọnụ ọgụgụ nke ndị na-anabata ya na imeju maka obere lipoproteins dị ala. Nke a na - eme ka nnabata ha na mkpofu ha kakwuo mma. A na-ebelatakwa usoro nke lipoproteins atherogenic. Na mgbakwunye, ịta nke protein dị ukwuu nke lipoprotein cholesterol na-abawanye ma triglycerides belata yana protein apolipoprotein B.

Ojiji nke Atorvstatin-Teva na-egosi nsonaazụ dị elu na ọgwụgwọ nke ọ bụghị naanị atherosclerosis, kamakwa ọrịa ndị ọzọ metụtara metabolism lipid, nke usoro ọgwụgwọ lipid belata adịghị mma.

Emebere ya na ihe ọghọm nke ọrịa ịba ọcha n'anya na akwara ọbara, dị ka nkụchi obi na ọrịa strok, belatara nke ukwuu.

Pharmacokinetics nke Atorvastatin-Teva

A na-etinye ọgwụ a ngwa ngwa. N'ihe dị ka awa abụọ, edekọwo ọgwụ kachasị elu na ọbara onye ọrịa. Mwepu, ya bụ, nnabata, nwere ike ịgbanwe ọsọ ya.

Dịka ọmụmaatụ, ọ nwere ike ibelata mgbe ị na-ewere mbadamba nri. Ma ọ bụrụ na itinye uche n'ụzọ dị otú a na-agbada, mgbe ahụ ọ naghị emetụta nsonaazụ nke Atorvastatin n'onwe ya - cholesterol na-aga n'ihu na-ebelata dabere na usoro onunu ogwu. Mgbe ị na-abanye n'ahụ ahụ, ọgwụ ahụ na-enwo usoro mgbanwe dị iche iche na eriri afọ. Ọ jikọtara ya nke ọma na protein plasma - 98%.

Mgbanwe mgbanwe metabolism bụ isi na Atorvastatin-Teva na-apata imeju n'ihi ikpughe iche iche. N'ihi nsonaazụ a, etolite metabolites na-arụ ọrụ, bụ nke nwere ike igbochi HMG-CoA reductase. 70% nke mmetụta ọgwụ niile na-adabara kpọmkwem n'ihi metabolites ndị a.

A na - ahụpụ Atorvastatin site na ahụ ya na hepatic bile. Oge oge ị theụ ọgwụ na ọbara ga-abụ ọkara nke mbụ (nke a na-akpọ ọkara ndụ) bụ awa iri na anọ. Mmetụta enzyme ahụ na-ewe ihe dị ka otu ụbọchị. Enweghị ihe karịrị pasent abụọ nke ego anabatara nwere ike kpebisie ike site na inyocha mmamịrị onye ọrịa. Maka ndị ọrịa nwere nsogbu gbasara akụrụ, a ga-echetarịrị ya n’oge ịba ọcha n’anya, Atorvastatin anaghị ahapụ ahụ.

Oke kachasị ọgwụ a na-agbaso karịa ụmụ nwanyị 20%, ọnụego mkpochapu ya bụ 10% belata.

N'ime ndị ọrịa na-arịa mmebi imeju n'ihi ị alcoholụbiga mmanya ókè na-egbu egbu, itinye uche kachasị na-abawanye site na ugboro iri na isii, ọnụego ntụpọ ahụ na-agbadata ugboro iri na otu, na-emegide usoro.

Ihe ngosi na contraindications maka ojiji

Atorvastatin-Teva bụ ọgwụ a na-eji n'ọtụtụ ọgwụ.

A na-eme ọgwụgwọ nke ọrịa ọ bụla na ọrịa a dị n'elu ebe a na-ahụ nri na - enyere aka belata cholesterol ọbara (nke dị elu na akwụkwọ nri na mkpụrụ osisi, mkpo, mkpị osisi, tomato, azụ, anụ ọkụkọ, akwa), yana enweghị nsonaazụ sitere na mbụ. etinyere ọgwụgwọ.

E nwere ọtụtụ ihe ngosipụta gosipụtara na ọ rụpụtara ezigbo ọrụ:

• atherosclerosis
• hypercholesterolemia,
• heterozygous ezinụlọ na hypercholesterolemia na-abụghị nke ezinụlọ.
• ụdị hypercholesterolemia agwakọta (ụdị nke abụọ dabere na Fredrickson),
• triglycerides dị elu (ụdị nke anọ dịka Fredrickson),
• ahaghioke nke lipoproteins (ụdị nke atọ dika Fredrickon si kwuo),
• Hyzycholesterolemia homozygous familial.

Enwere ọtụtụ contraindications maka iji Atorvastatin-Teva:

1. Ọria imeju na ọkwa nọ n'ọrụ ma ọ bụ n'oge ọnọdụ iwe.
2. Mmụba na ọkwa nke ọrịa ịba ọcha n'anya (ALT - alanine aminotransferase, AST - aspartate aminotransferase) karịrị ugboro atọ, na-enweghị ezigbo ihe kpatara ya,
3. Imeju imeju.
4. Ime na lactation.
5. Obere ụmụaka.
6. Ngosiputa azumahia mgbe ị na - ewere ihe obula nke ogwu.

N'ụfọdụ oge, ọgwụ ndị a kwesịrị iji nlezianya debe ọgwụ ndị a. Ndị a bụ ikpe dịka:

• ị excessiveụbiga mmanya ókè,
• oria ogwu ichoro,
• hormonal ahaghị nfe,
• ahaghioke nke electrolytes,
• nsogbu metabolic
• ọbara mgbali ala
• nnukwu ọrịa ọnya
• Akwụkwụ na-adọghị agwọ
• arụmọrụ buru ibu na mmerụ ahụ

Na mgbakwunye, ịkpachara anya mgbe ị na-a theụ ọgwụ ahụ kwesịrị iji ya na ọnụnọ nke pathologies nke usoro akwara.

Mmekọrịta na ọgwụ ndị ọzọ

Atorvastatin-Teva juputara na mmepe nke myopathy - adịghị ike nke ahụ ike, dịka ọgwụ niile dị na otu nke HMG-CoA reductase inhibitors. Site na ijiri ọtụtụ ọgwụ, enwere ike ịbawanye ọrịa a. Ndị a bụ ọgwụ ọgwụ dịka fibrates (otu n'ime ọgwụ ọgwụ anticholesterolemic), ọgwụ nje (erythromycin na macrolides), ọgwụ antifungal, vitamin (PP, ma ọ bụ nicotinic acid).

Ndị otu a na-eme ihe na enzyme pụrụ iche akpọrọ CYP3A4, nke na-arụ nnukwu ọrụ na metabolism Atorvastatin-Teva. Site n'ụdị ọgwụgwọ njikọta a, ọkwa nke atorvastatin dị n'ọbara nwere ike ịbawanye n'ihi mmachi nke enzyme ahụ a kpọtụrụ aha na mbụ, ebe ọgwụ adịghị metabolized nke ọma. Nkwado nke ndị otu ahụ dị, dịka ọmụmaatụ, Fenofibrate, gbochie usoro mgbanwe nke Atorvastatin-Teva, n'ihi ọnụ ahịa ya na ọbara na-abawanye.

Atorvastatin-Teva nwekwara ike iduga mmepe nke rhabdomyolysis - nke a bụ ọrịa mara mma nke na - apụta dịka nsonaazụ nke myopathy ogologo oge. N'ime usoro a, akwara anụ ahụ na-aga mbibi dị ukwuu, a na-ahụ oke ha na mmamịrị, nke nwere ike ibute oke gbasara akụrụ. Rhabdomyolysis na-etolitekarị site na iji Atorvastatin-Teva na otu ọgwụ ọgwụ dị n'elu.

Ọ bụrụ n’ịdee ọgwụ n ’ụzọ kachasị anabata kwa ụbọchị (80 mg kwa ụbọchị) yana Digoxin cardiac, mgbe ahụ enwere mmụba na mkpokọta Digoxin ihe dị ka otu ụzọ n’ime ụzọ ise nke ọgwụ a were.

Ọ dị ezigbo mkpa ijikọta iji Atorvastatin-Teva na ọgwụ mgbochi ọmụmụ nke nwere estrogen na usoro ya, ebe ọ bụ na enwere mmụba na ọkwa nke homonụ nwanyị. Ọ dị ndị inyom gbara afọ aka.

N’ihe nri, a na-atụzi anya ka ọ belata ihe ọ juiceụpeụ mkpụrụ osisi vaịn, ebe o nwere ihe karịrị otu ihe na-egbochi enzyme, n’okpuru nke usoro metabolic isi nke Atorvastatin-Teva na-ewere ọnọdụ na ọkwa ya na ọbara na-abawanye. Enwere ike ịzụta ọgwụ a n'ụlọ ahịa ọgwụ ọ bụla nwere ọgwụ edenye ya.

Enyere ozi banyere ọgwụ Atorvastatin ọgwụ na vidiyo dị n'isiokwu a.