Rosuvastatin: ntuziaka maka ojiji, ịdọ aka ná ntị na nyocha

Nkọwa nke metụtara 18.07.2014

• Aha Latin: Rosuvastatin
• Koodu ATX: C10AA07
• Arụ Ọrụ: Rosuvastatin (Rosuvastatin)
• Emeputa: CANONPHARMA, Russia

A na-ekpuchi mbadamba ọ bụla. Ihe bụ isi bụ rosuvastatin.

• ọka ọka
• stereta magnesium,
• microcrystalline cellulose,
• povidone
• calcium hydrogen phosphate mmiri riri.

Ihe ndị mejupụtara ihe nkiri ahụ:

• selecate AQ-01032 acha ọbara ọbara,
• titanium dioxide
• hypromellose,
• macrogol-400,
• macrogol-6000.

Dabere na usoro onodu ogwu (10 mg, 20 mg, 40 mg), nhazi nke mbadamba ihe gbanwere.

Ihe ngosi maka ojiji

Rosuvastatin ọgwụ a ga-ewere:

• na hypercholesterolemia (dika mgbakwunye na nri ma ọ bụrụ na usoro ndị ọzọ ọgwụgwọ anaghị arụ ọrụ),
• na hypertriglyceridemia (dika mgbakwunye na nri).

Ihe ngbanwe

A na - egbochi ọgwụ a na ndị nwere ọgwụ mmụọ na akụkụ ọgwụ ahụ.

Ọzọkwa, ọrịa ndị na-esonụ bụ contraindications iji drugụ ọgwụ mbụ:

Na nke afọ ime na inye ara ọgwụ bụkwa contraindicated.

A dụrụ ọdụ ka ọ toụọ ọgwụ a nye ndị nwere:

• sepsis,
• n'oge ịwa ahụ,
• na ọgba aghara endocrine,
• ya na mmerụ ahụ.

Ikwesiri ịkpachara anya na iji Rosuvastatin nye ndị nnọchi nke agbụrụ Eshia.

Maka ndị gbara afọ 18 na mgbe afọ 65 gasịrị, a naghị atụ aro ọgwụ a.

Nsonaazụ

Ọgwụ a nwere ụdị dịgasị iche iche nke nsonaazụ ndị enwere ike ibute:

Usoro akwara:

Usoro ụjọ:

Usoro okuku ume:

Usoro ure:

• na-efe efe
• mgbu na ala afọ.

Ọkpụkpụ afọ:

Obi ọnụego:

Mmekorita

Antacids enwere ike iwere ya naanị oge ụfọdụ (ihe dị ka awa 2) mgbe ị takingụ ọgwụ a, ebe ọ bụ na ojiji ha na-eduga n'ịbelata mkpokọta Rosuvastatin.

Erythromycin ekwesighi ka eji ya rosuvastatin mee ya, ebe obula ichikota ogwu n’obelata.

Pharlọ ọgwụ Pani

Mmụta: Ọ gụsịrị akwụkwọ na Rivne State Basic Medical College na nzere ya na ahịa ọgwụ. Ọ guru akwukwo na Vinnitsa State Medical University. M.I. Pirogov na ihe omumu banyere ya.

Ahụmahụ: Site na 2003 ruo 2013, ọ rụrụ ọrụ dị ka onye na-ere ọgwụ na onye njikwa nke ụlọ ahịa ọgwụ. E nyere ya akwụkwọ ozi na ọdịiche maka ọtụtụ afọ nke ọrụ akọ na uche. E bipụtara edemede gbasara isiokwu ahụike na mbipụta mpaghara (akwụkwọ akụkọ) yana na ọnụ ụzọ ntanetị dị iche iche.

Maka ndị nke triglycerides adịghị agbago n'ọkwa dị oke egwu, anaghị m enye ndụmọdụ maka rosuvastine, enwere ọtụtụ mmetụta ndị na-adịghị mma, egwuregwu ahụ ekwesighi ka ọkụ kandụl ahụ, m na-ekpe onwe m ikpe. Ugbu a, m na-anabata dibikor, ọ na-abụkarị LDL na HDL, ọ dị milder, mana ọ na-adịkwa irè. Ọ dị mma, ọ bụrụ na ị ka enweghị ike ime na-ejighi statin, ọ ka mma ijikọ dibicor iji belata nsonaazụ, dọkịta gwara m.

Ana m ewere analogue nke ọgwụ a, a na-akpọ ya Rosuvastatin-SZ. Onye dibia bekee dere ya ede ogologo oge, iji gbochie obi oria, o nagide oru nke iwetulata cholesterol nke oma, wee belata ya site na 7.9 rue 5.5 n’ime ọkara n’afọ. Mgbe mgbe, ha na-ede banyere nsonaazụ ndị ọzọ, mana enweghị onwe m enweghị ihe dị ka nke a, enwere m mmetụta nke ịbụ onye nkịtị.

Ngwakọta na usoro onunu ogwu

Rosuvastatin bụ ọgwụ ndị na-egbusi ike nke Statin otu. Subclass - HMG-CoA reductase inhibitors. N'ihi ihe a dị na ọgwụ ọgwụ, mkpokọta intracellular nke lipids na-ebelata, ọrụ ndị na-anabata ndị na-enweta ọgwụ LDL na-abawanye ụgwọ, yana n'ihi nke a, ha na-amịpụ ngwa ngwa ma napụpụ n'ọbara ọbara. Na mgbakwunye, dị ka statins ndị ọzọ, rosuvastatin nwere mmetụta dị mma na endothelium, na-egbochi nsị ya (na-egbochi mmepe nke atherosclerosis mbụ na ogbo ahụ), na mgbidi akwara (na-echebe ya na cholesterol na-emebi emebi irighiri). Isi isoenzymetinyere aka na metabolism rosuvastatin - CYP2C9

Releasedị mgbapụta nke rosuvastatin bụ mbadamba. Ha bụ pink na agba, convex n'akụkụ abụọ, kpuchie ya na fim. Na mmejọ, ihe dị n'ime dị na agba na-acha ọcha. Ngwakọta kachasị arụ ọrụ na mbadamba - calcium rosuvastatin - dị na 5 mg, 10 mg na 20 mg. Dabere na usoro onodu ogwu, uzo nke mbadamba iche di iche. Rounddị okirikiri nke usoro onunu ogwu maka ihe na-arụ ọrụ bụ 5 mg na 20 mg, ụdị elongated bụ 10 mg na 40 mg.

N'ime ụlọ ahịa ọgwụ, ịnwere ike ịzụta kaadiboodu nke nwere blisters nke 6, 10, 14, 15 ma ọ bụ mbadamba 30 n'ime nke ọ bụla, dabere na nha, ma ọ bụ iberibe 30 na 60 na ite. Na mgbakwunye na akụrụngwa bụ isi (n'eziokwu, rosuvastatin - aha nke mba ụwa), ihe mejupụtara ọgwụ ahụ nwere ọtụtụ ihe ndị ọzọ: povidone, ọka ọka, stereti magnesium, microcrystalline cellulose. Ngwakọta nke shei gụnyere ngwakọta akọrọ: talc, macrogol, titanium dioxide, iron oxide (red). Dabere na onye nrụpụta, ihe mejupụtara a nwere ike ịdị iche nwa oge.

N'elu, anyị nyochara ihe mejupụtara mbụ rosuvastatin Canonpharma nke emeputa (mba - Russia). Ọzọkwa taa anyị ga-atụle analogues nke ọgwụ a dabere na radar ọgwụ (aha ọgwụ), wee chọpụta onye nrụpụta na shelves ụlọ ahịa ọgwụ ka mma na ọnụahịa.

Nsonaazụ

N’okpuru aro ndị ọgwụ kwuru na usoro ị doụ ọgwụ kwa ụbọchị, rosuvastatin na-akpata nsonaazụ ndị ọ na-adịkarị obere. Ma ọ bụghị, site na iji ọgwụgwọ na-adịghị mma, ọgwụ ahụ nwere ike iweta ma uru ma mmerụ ahụ. A na-enye iwu ka ihe ndị metụtara mmetụta dị ka ndị otu WHO (WHO) si kwuo: oge ​​mgbe, mgbe ụfọdụ, mgbe ụfọdụ, ikpe ndị dịpụrụ adịpụ, nke kachasị njọ, adịghị ọcha. Ugbu a, anyị ga-enyocha kpọmkwem ihe nsonaazụ ndị bụ njirimara na ekwesịrị iburu n'uche maka ọgwụ a.

• Mgbakasị usoro iwu nke Humoral: mmepe nke ọrịa shuga mellitus (DM) na-abụghị insulin na-adabere.
• Ọrịa mgbochi ọrịa na nrụghachi ọrụ: mmeghachi omume hypersensitivity, urticaria, edema.
• CNS - ihe mgbu na isi, dizziness.
• Ọkpụkpụ na akwara - olu mgbu (myalgia), myopathy, rhabdomyolysis n'ihi ọdịda akụrụ, n'ọnọdụ ndị na-adịghị ahụkebe (1 n'ime mmadụ 10,000) - na-eme ka ihe ọgbaghara ghara ịdị. N'oge na-adịghị anya - arthralgia, myositis. Ọ dị mkpa iji nyochaa ọkwa nke ọrụ enzyme nke creatine phosphokinase ma nwee mmụba dị ukwuu na ntinye (ugboro ise ma ọ bụ karịa karịa nke a), a na-akagbu ọgwụgwọ na rosuvastatin.
• Ahụ gastrointestinal - mgbu afọ, afọ ntachi, ọgbụgbọ.
• Sistem (Urinary) - protein dị na mmamịrị (proteinuria), na-edokarị n'oge a na-agwọ ya, ọ bụghị akara akara ụfọdụ ọrịa akụrụ gbasara akwara.
• Akpukpo na PUFA - itching, urticaria, erythematous rash.
• Imeju - mgbanwe na-agbanwe agbanwe na enzymes imeju - transaminases na mmụba ọ bụla na ha.
• Usoro Laboratory - bilirubin, alkaline phosphatase, gamma-glutamintranspeptidase nwere ike ịbawanye ụba, n'ọnọdụ ndị a na-adịghị ahụkebe, enwere ike ịkọwa mkpesa arụmọrụ sitere na gland thyroid.
• Ihe mgbaàmà ndị ọzọ bụ asthenia.

Ọtụtụ mgbe ndị ọrịa na-ajụ ajụjụ a - okpomọkụ ọ̀ na-abawanye mgbe ha na-ewere rosuvastatin? Mba, ọ bụghị. Ọ ga-amasịkwa m ịghọta na enweghị nkwekọrịta na statins nwere mmanya, yabụ ndị ọrịa kwesịrị ịkwụsị ị drinkingụ mmanya n'oge ọgwụgwọ, ma ọ bụghị ya, o nwere ike ịbawanye mgbe ọ bụla, uru ọ ga-ekwe omume bụ, ee, ee e.

Ntụziaka maka ojiji

Dị ka ọ dị, usoro ọgwụgwọ mbụ nke rosuvastatin bụ 5-10 mg kwa ụbọchị, dabere na ebumnuche ọgwụgwọ na ọnọdụ nke onye ọrịa na ahụ ya. Tupu usoro ọgwụgwọ, a ga-ahụrịrị usoro ọgwụgwọ nri iji belata cholesterol ọbara. N'ụzọ were ya n'aka nri rosuvastatin?

Ọgwụ nwere ike ị drunkụ mmanya n'agbanyeghị nri, ozugbo dum ọgwụ kwa ụbọchị maka 1 oge. Ekewala mbadamba nkume ahụ, edetụla ya ma ọ bụ gwerie ya, were ya na mmiri dum, jiri iko mmiri. A na-ahọrọ usoro onunu ogwu iche iche nke ọma. Ọ bụrụ na ọ dị mkpa, ka izu anọ gachara, dibịa na-aga ahụ nwere ike ịbawanye ọgwụ iji nweta nsonaazụ achọrọ.

N'ime nhọrọ nke ịkọ ọgwụ kwa ụbọchị nke 40 mg, ihe ize ndụ nke mmeghachi omume ọjọọ na-abawanye nke ukwuu, yabụ, egoro ọgwụ a maka ọnọdụ dị njọ nke hypercholesterolemia yana nnukwu ihe egwu nke nsogbu site na sistem vaskụla na obi, ma ọ bụrụ na ọnụọgụ 20 mg enyeghị mmetụta achọrọ tupu. Ọ dị mkpa iji nyochaa oke mmachi nke metabolism lipid mgbe izu 2-4 gachara site na mmalite ọgwụgwọ ma ọ bụ mmụba na usoro onunu ogwu.

Ọ bụrụ na onye ọrịa ahụ nwere ọrịa na - efe efe site na akụrụ, umeji, olu musculoskeletal, ebumnuche nke myopathy, mgbe ahụ usoro ọgwụgwọ akwadoro maka ya bụ 5 mg kwa ụbọchị. Ugbu a, ka anyị gosipụta ogologo oge ọ ga-ewe iji rosuvastatin. Edepụtara usoro ọgwụgwọ ya n'otu n'otu, mana oge ya dịkarịa ala otu ọnwa.

Jiri n’oge ime

Yiri ndị ọzọ akpụ, a na-anabataghị rosuvastatin n’oge ime na lactation.

Afọ ụmụaka bụ otu n'ime contraindications nke rosuvastatin. Enweghi omumu ihe omimi zuru oke banyere ihe omuma aru ahu aruputara, ya mere ejiri ihe statin a eme ihe.

Ọnụ ahịa ọgwụ ọjọọ

Maka ọtụtụ ndị ọrịa, na mgbakwunye na ogo na mmetụta nke ọgwụ, ọnụahịa ya dị na ebe dị mkpa. Maka rosuvastatin, ọnụahịa ahụ na-adịkarị larịị ma e jiri ya tụnyere ọnụ ahịa ndị na-adị ala analogues. Ego ole ka rosuvastatin na-eri? Dabere na mpaghara, ọnụahịa ahụ dị iche iche n'otu n'otu ahụ. Na Russia na pharmacies nke Moscow, a na-ere ọgwụ na ọnụahịa ndị a:

• maka mbadamba 30 nke 5 mg - ọnụahịa sitere na 510 rubles
• maka mbadamba 30 nke 10 mg - ọnụahịa sitere na 540 rubles
• maka mbadamba 30 nke 20 mg nke ọ bụla - ọnụ ahịa site na 850 rubles

Na Ukraine ọnụ ahịa rosuvastatin dị obere. Akara ego dị na ụlọ ahịa ọgwụ Kiev dị n'ụkpụrụ ndị a:

• maka 28 pcs. 5 mg ọ bụla - ọnụahịa site na 130 UAH
• maka 28 pcs. 10 mg nke ọ bụla - ọnụahịa sitere na 150 UAH
• maka 28 pcs. 20 mg ọ bụla - ọnụahịa sitere na 230 UAH.

N'ezie, ọnụahịa na-adabere na ụlọ ọrụ nke onye nrụpụta, njirimara nke agbụ ụlọ ahịa ọgwụ na iwu ọnụahịa akọwapụtara nke mpaghara ndị dị na mba ahụ.

Nyocha Nyocha

N'ime ndị ọrụ ahụike, nyocha nke rosuvastatin bụ ihe dị mma. A na-ewere ya dị ka ọgwụ ịhọrọ ọhụụ maka hypercholesterolemia nwere ọnụahịa dị mma / mma. A na-edenye ya mgbe ụfọdụ iji chịkwaa atherosclerosis. Site n'ịkwusi larịị ahụ, belata nkụchi obi na ọrịa strok belata.

Petrenkovich V.O. dọkịta nke omume ezinụlọ nke ngalaba kachasị elu, Vinnitsa: “N'omume m, ejiriwo m rosuvastatin mee ihe ọtụtụ oge na oge. Maka ndị ọrịa, ọ masịrị m ịde ya dịka Roxer. N'okwu niile, ana m ahụ mmetụta dị mma na-adakarị. Ọrịa anaghị eme mkpesa banyere mmeghachi omume ọjọọ, a na-anabata ọgwụgwọ nke ọma. Ọgwụ a na-adịchaghị oke ọnụahịa "

N'agbanyeghị eziokwu ahụ bụ na ọtụtụ mgbe ndị mmadụ na-atụ egwu na nsonaazụ nke nsonaazụ nke ị roụ rosuvastatin, n'etiti ndị na-ewere ihe ọ bụla edepụtara adịghị ekwupụta mgbaàmà ọjọọ. Ọnụahịa ahụ na nsonaazụ a na-atụ anya ya nke iwere rosuvastatin gosipụtara nzube ya.

Gorelkin Pavel, Novorossiysk: “Ọtụtụ afọ ugbu a, ndị dọkịta ekwuola na enwere m cholesterol dị elu. N'ime afọ 42, enwere m egwu nke ukwuu ịnwụ site na nkụchi obi. N'ụlọ ọgwụ mpaghara, a gwara m ka m malite ị drinkingụ Suvardio. Mgbe ihe dị ka otu ọnwa na ọkara, ule m dịchasịrị mma, ọ bịara dịrị mkpụrụ obi m mfe. Kedu maka ọnụahịa ahụ? Ọ dị mma, ọnụahịa anaghị ata oke oke, yabụ enwere m ike imeli ya. Aga m aga n’ihu ọgwụgwọ ”

Belchenko Z.I., 63 afọ, obodo. Akhtyrsky: “Kemgbe ọtụtụ afọ, ejirila m ọgwụ na-agwọ ndị kọlestrọl m. Ihe m na-anwaleghị, ọ nweghị ihe nyeere m aka. N’afọ gara aga, onye agbata obi gwara m ka m gaa hụ dọkịta ọhụrụ n’ụlọ ọgwụ. Edere m akwụkwọ ahụ rosuvastatin. A gwara m ọgwụ ọhụrụ a ma mara mma nke ukwuu. Agbanyeghi na onu ahia m riri m onu ​​karie, onu ahia bu onu ahia, mana a ka m na a drinkingu ya otua ugbua ma enwerem cholesterol. ”

Makashvili O.B., Afọ karịrị afọ iri ise, Kerch: “Ndụmọdụ nwanne ya nwoke, Tevastor malitere. Ọrịa shuga m kara njọ. Agara m ụlọ ọgwụ, ebe ha ji ọgwụ ọzọ dochie ọgwụ ahụ, mana ọ fọrọ obere ka ọ bụrụ otu ọnụ ahịa. Ọ bịara bụrụ na ekwesịghị ịrịa ọrịa shuga Tevastor. ”

Dịka ị pụrụ ịhụ, dịka nyocha nke ma ndị dọkịta ma ndị ọrịa, rosuvastatin nwere ọnụahịa dị mma / ịdị mma. Rosuvastatin bụ ọgwụ ọgbara ọhụrụ ọfụma. Site na ịgbasochi anya maka ndụmọdụ ahụike, ọ nwere profaịlụ nchekwa dị elu, enwere ike ịkọwa ya ogologo oge.

Ngwakọta na ụdị ntọhapụ

Emepụtara ọgwụ Rosuvastatin n'ụdị mbadamba, mbadamba ihe mkpuchi fim maka nchịkwa ọnụ. Ha nwere obere pink ma ọ bụ agba pink, ọdịdị gburugburu na elu biconvex.

A na-ekpuchi mbadamba ọ bụla. Ihe bụ isi bụ rosuvastatin.

• ọka ọka
• stereta magnesium,
• microcrystalline cellulose,
• povidone
• calcium hydrogen phosphate mmiri riri.

Ihe ndị mejupụtara ihe nkiri ahụ:

• selecate AQ-01032 acha ọbara ọbara,
• titanium dioxide
• hypromellose,
• macrogol-400,
• macrogol-6000.

Dabere na usoro onodu ogwu (10 mg, 20 mg, 40 mg), nhazi nke mbadamba ihe gbanwere.

Omume ọgwụ

Rosuvastatin bụ ihe na-eweta ike dị ala, ihe na - agbanwe asọmpi hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, nke bụ enzyme nke na - agbanwe 3-hydroxy-3-methylglutaryl CoA na ihe cholesterol - mevalonate. Ọgwụ ahụ na-eme ka ọnụ ọgụgụ ndị na-anabata LDL (lipoproteins dị ala) dị ala nke mkpụrụ ndụ imeju, na-ebute ịba ụba catabolism na mmụba nke LDL yana njikọ nke VLDL (lipoproteins dị obere) na-egbochi. Na ngwụcha, ọnụ ọgụgụ nke VLDL na LDL belatara.

N'okpuru ọrụ nke Rosuvastatin, mmụba nke OXC (cholesterol ngụkọta), cholesterol-LDL (cholesterol low density lipoproteins), TG (triglycerides), ApoB (apolipoprotein B), TG-VLDL na VL-VLDL na-ebelata. Ọgwụ a na-eme ka itinye uche nke HDL-C (HDL cholesterol) na ApoA-I (apolipoprotein A-I). Rosuvastatin na-ebelata ndepụta atherogenicity, na-emeziwanye profaịlụ egbugbere ọnụ ndị ọrịa nwere hypercholesterolemia.

Mmetụta ọgwụgwọ nke ọgwụ ahụ na-ebido n'ime izu mbụ mgbe mmalite nke nchịkwa ya, rute karịa site na izu nke anọ nke usoro ahụ.

Mlọ ọgwụ

Oke plasma ịta n'ihe arụ ọrụ erutela awa ise ka ewere Rosuvastatin. Ihe zuru oke banyere ihe dị ka 20%.

Isi metabolism bụ nke imeju na-ebu. Olu nke nkesa bụ lita 134. Ihe dị ka 90% nke ihe ahụ na-egbochi protein ndị dị na plasma (ọkachasị na albumin). Ihe bụ isi metabolites bụ lactone metabolites (anaghị arụ ọrụ ọgwụ) na N-desmethylrosuvastatin (50% dị obere karịa rosuvastatin).

Ihe dị ka 90% nke ọgwụ aere dị na eriri afọ anaghị agbanwe agbanwe, akụrụ fọdụrụnụ. Plasma ọkara ndụ bụ awa 19.

Ọgwụ ọgwụ nke rosuvastatin anaghị adabere na nwoke na nwanyị na afọ nke onye ọrịa.

N'ime ndị agbụrụ Mongoloid, enwere mmụba okpukpu abụọ na mkpokọta plasma nke rosuvastatin na AUC nke etiti (mpaghara n'okpuru oge ịta ahụhụ) ma e jiri ya tụnyere ndị ọrịa Caucasoid, na ndị India kachasị plasma plasma na ntụgharị uche nke AUC site na 1.3 ugboro, na ndị nnọchite nke agbụrụ Neroid ọgwụ pharmacokinetic yiri ndị nke Caucasians.

Ọdịda obere obere akwara na-adịghị emetụta ịta nke rosuvastatin na metabolic N-desmethylrosuvastatin. N’agha siri ike gbasara akụrụ, ịta plasma nke rosuvastatin na-ebili ihe dị ka ugboro atọ, na N-desmethylrosuvastatin ruo ugboro itoolu. N'ime ndị ọrịa na hemodialysis, ịta nke ihe dị n'ọrụ dị ihe dịka 50% dị elu.

N'ime ndị ọrịa nwere oke ịba ọcha n'anya, ọkara nke rosuvastatin nwere ike ịbawanye opekata mpe ugboro abụọ.

Ndenye ọgwụ n'oge ime na lactation

Rosuvastatin na statins ndị ọzọ bụ contraindicated na ime. E nwere ihe akaebe na ọgwụ a na-emetuta mmepe nke nwa ebu n’afọ, na-abawanye ihe ọghọm nke ịdọpụ nwa amụrụ ọhụrụ. Womenmụ nwanyị dị afọ iri na-amụ maka ịmụ nwa na-eji ụzọ dị mma eji egbochi afọ ime eme ihe.

Ọ bụrụ na ịtụrụ ime emebeghị atụmatụ, mgbe ahụ ị pụ ọgwụ maka kọlestrọl kwụsị ozugbo. A naghị akwado ya ka inye ara ara maka oge a treatmentgwọ ọgwụ ọgwụ a.

Usoro onunu ogwu na uzo ochichi

Dika esi gosi ya na ntuziaka eji eme rotavastatin, ewere ya were ọnụ, egbula tebụl ahụ ma ọ bụ gwerie ya, were mmiri .ụchaa mmiri. Enwere ike ịkọ ọgwụ a n'oge ọ bụla n'ụbọchị, n'agbanyeghị oge nri.

Tupu ịmalite ọgwụgwọ na Rosuvastatin, onye ọrịa kwesịrị ịmalite ịgbaso usoro hypocholesterolemic nri ma nọgide na-agbaso ya n'oge ọgwụgwọ. Ekwesịrị ịhọrọ dose nke ọgwụ ahụ n'otu n'otu dabere na ebumnuche nke usoro ọgwụgwọ na azịza ọgwụgwọ maka ọgwụgwọ, na-eburu n'uche ugbu a na ebumnuche mkpụrụ ndụ.

• Usoro akwadoro ka ndị ọrịa malite ị takeụ ọgwụ, ma ọ bụ maka ndị ọrịa wefere na ị takingụ ọgwụ mgbochi ndị ọzọ HMG-CoA, kwesịrị 5 ma ọ bụ 10 mg ọgwụ Rosuvastatin 1 oge / ụbọchị. Mgbe ị na-ahọrọ usoro ọgwụgwọ mbụ, mmadụ kwesịrị iburu ọdịnaya nke cholesterol dị iche iche n'uche ma chebara ihe egwu ọrịa obi nwere ike ịdị, yana ọ dịkwa mkpa ịtụle ihe ọghọm dị na nsonaazụ ọ bụla. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ ka ukwuu ka izu anọ gachara (lee mpaghara “Pharmacodynamics”).
• N'ihi mmepe ga - ekwe omume ị effectsụ nsogbu ọ bụla mgbe ị na - a ofụ ọgwụ 40 mg, ma e jiri ya tụnyere obere usoro ọgwụ ahụ (lee mpaghara “Side side”), ịbawanye dose ahụ gaa na 40 mg mgbe ọgwụ agbakwunyere dị elu karịa usoro akwadoro nke mbụ maka izu anọ. Enwere ike ịme ọgwụgwọ naanị na ndị ọrịa nwere nnukwu hypercholesterolemia na nnukwu ihe egwu nke ọrịa obi (ọkachasị ndị ọrịa nwere familial hypercholesterolemia) ndị na-enwetabeghị nsonaazu ọgwụ chọrọ mgbe ị na-a aụ ọgwụ 20 mg, oleekwa onye ga-eme ya? t n'okpuru nlekọta nke a ọkachamara (lee. ngalaba "Special ntụziaka"). A na-atụ aro iji nlezianya nyochaa ndị ọrịa na-anara ọgwụ ahụ na ọgwụ 40 mg.

A naghị atụ aro ka a sụọ ọgwụ were 40 mg maka ndị ọrịa na-agabeghị dọkịta. Mgbe izu 2-4 nke usoro ọgwụgwọ na / ma ọ bụ mmụba na dose nke Rosuvastatin, nlebara anya metabolism dị mkpa (mmezi dose dị mkpa ma ọ bụrụ na ọ dị mkpa). Ejighi iji ọgwụ eme ihe n'ọtụtụ dị elu karịa 40 mg adịghị ọcha n'ihe metụtara mmụba nke nsonaazụ yana n'ọtụtụ oge anaghị atụ aro ya.

1. Site na njikwa nke creatinine nke 30-60 ml / min, a na-enye Rosuvastatin na usoro ọgwụ nke 5 mg. Ihe ọgwụ a na-eme kwa ụbọchị nke 40 mg na-egbochi ọgwụ. Edeghị ndị ọrịa nwere ikike imebi ihe na-erughị 30 ml / min, yana ikpe nke ọrịa imeju na usoro ọrụ.
2. Usoro akwadoro ịmalite maka ndị ọrịa nke agbụrụ Mongoloid bụ 5 mg. N'ịgwọ 40 mg, enyeghị ọgwụ a maka ndị otu a.
3. Maka ndị ọrịa na-eburu genotypes c.521SS ma ọ bụ s.421AA, a na-atụ aro aro kachasị nke Rosuvastatin kwa ụbọchị bụ 20 mg.
4. N'ihe banyere ọnọdụ metụtara myopathy, usoro ọgwụgwọ akwadoro nke mbụ bụ 5 mg, ihe kachasị bụ 20 mg.
5. Mgbe ị na-ede akwụkwọ ịgwọ ọrịa nkwonkwo, ọ dị mkpa iji chọpụta ma eleghị anya ọrịa myopathy.

Mmetụta akụkụ

Mpụ ndị a na-ahụ n'oge usoro ọgwụgwọ na-abụkarị ọgwụ dabere na nke enweghị ọrụ, na-apụ naanị nke ha.

Enwere ike ịmeghachi omume na-adịghị mma (> 10% - ọtụtụ mgbe,> 1% na 0.1% na 0.01% na Sasha. Onye na-agwọ ọrịa nyere m iwu rosuvastatin 1 otu ugboro n'abalị. Amalitere m ị drinkingụ mmanya na obi m malitere ịkụ ihe dị oke egwu. O buru na ibu abiala karia, odi ka moto ahu na aru aru ike. Ajulam i drinking nu ma oburu na obia ndi ozo juru a. Aguturu m ntuziaka na ha nwere ike imeghachi obi obi ha.

E nwere ọtụtụ ọgwụ nwere otu arụ ọrụ dị ka rosuvastatin, yabụ enwere ike iji ya dịka ndị ọzọ. Agbanyeghị, tupu iji ha, a na-atụ aro ka ị kpọtụrụ dọkịta gị.

Uzo ndị a gụnyere:

Tupu ịzụta analog, gwa dọkịta gị.