21 May, 2024
    Ọgwụ

    Nyocha maka Rosucard

    Ihe kachasị dị na Rosucard bụ rosuvastatin. Ọ na-abụkarị nsonaazụ nke ọgwụ na-apụta na imeju - akụkụ ahụ kachasị maka njikọta cholesterol. Rosucard na-agbadata ọkwa lipoproteins dị ala (LDL), nke ahụ bụ "ọjọọ" cholesterol ma na-abawanye ọkwa "ezigbo" cholesterol (HDL - lipoproteins dị elu).

    Otu izu mgbe ịmalite Rosucard, a na-egosipụta mmetụta ọgwụgwọ dị mma ya. Enwere ike nweta ọganihu kachasị elu izu abụọ mgbe ịmalite ọgwụgwọ na Rosucard. Iji nweta mmetụta na-adigide, usoro ọgwụgwọ kwesịrị ịdịkarịa ala otu ọnwa.

    Ihe ngosi maka ojiji nke Rosucard bu:

    • hypercholesterolemia,
    • gwakọtara dyslipidemia,
    • ọrịa hypercholesterolemia,
    • atherosclerosis.

    Ọzọkwa, edepụtara ọgwụ a iji gbochie mmepe nke ọrịa obi na ndị ọrịa nọ n'ihe ize ndụ.

    Otu njiri mara nke Rosucard bụ na tupu ịmalite ị theụ ọgwụ, onye ọrịa ga-ebido ịgbaso nri nwere obere kalori ma rapara ya na oge ọgwụgwọ niile. Dịka ntuziaka ahụ si dị, a ga-ewere Rosucard n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri nri.

    Ọ bụ dọkịta ka ọ họọrọ ị doseụ ọgwụ ọ bụla, na-eburu n'uche ebumnuche na mmeghachi omume nke onye ọrịa. N'ọnọdụ ka ukwuu, ọgwụ mbụ nke Rosucard bụ 10 mg. Mgbe ọnwa gachara, enwere ike ịba ụba ya ruo 20 mg. N'okwu kachasị siri ike, a na-enye 40 mg nke Rosucard ọgwụ. A na-enye ọgwụ a contraindicated n'ime ụmụaka na-erubeghị afọ 10.

    Mgbe ị na-ewere Rosucard, enwere ike ịchọpụta ụfọdụ mmetụta ndị ọ na-enwe. Yabụ na mgbe ọgbụgba ya na isi ọwụwa ya, ahụ erughị ala site na eriri afọ, ya bụ mgbu afọ, ọgbụgbọ, afọ ntachi, enweghị nsogbu nke akpịrị. Ihe di oke nhu bu nsogbu ihi ura, ya na usoro mkpali na imeju. Nsonaazụ Rosucard, dịka iwu, bụ dabere na dose.

    Ihe ndi mmadu na egbochi ndi mmadu.

    • onye anabataghi,
    • ọrịa ọrịa imeju dị iche iche, gụnyere ịba ụba transaminase.
    • ọrịa akụrụ
    • na-ewere cyclosporine,
    • ime na lactation,
    • myopathies.

    Site na nlekọta pụrụ iche, a na-enye Rosucard ndị ọrịa agbụrụ Asia ma ọ bụ karịa afọ 70, yana hypothyroidism, ahoụrụma, ịgwọ ọrịa fibrates na mgbe ọrịa akwara. Mgbe ị na-ewere Rosucard, ndị nwere glucose ọbara dị elu nwere ihe ize ndụ nke ịmalite ọrịa shuga.

    N'ime ụdị ndị ọrịa a, tupu ịkọwa Rosucard, ọ dị mkpa ịtụle ihe ize ndụ ndị dị ugbu a yana mmetụta ọgwụgwọ ọgwụgwọ ahụ buru amụma. Mgbe ị na-edepụtara ha ọgwụ ahụ, a na-atụ aro ka a na-eme ọgwụgwọ n'ụlọ ọgwụ n'okpuru nlekọta ahụike na-aga n'ihu.

    Tupu ịmalite usoro ọgwụgwọ na Rosucard, a na-adọ ndị ọrịa aka ná ntị banyere mkpa ọ dị ịgwa dọkịta na-abịa nso banyere ọdịdị mgbu mgbu, nkwonkwo, adịghị ike, karịsịa na oke ịrịa ọrịa na ọbara mgbali elu. Emere mkpebi iji kagbuo ma ọ bụ nọgide na-a theụ ọgwụ ahụ dabere na data nyocha.

    Analogs nke Rosucard

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 54 rubles. Ihe analogue dị ọnụ ala site na 811 rubles

    Dakọtara dị ka egosi

    Ọnụahịa site na 324 rubles. Ihe analogue dị ọnụ ala site na 541 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 345 rubles. Ihe analogue dị ọnụ ala site na 520 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 369 rubles. Ihe analogue dị ọnụ ala site na 496 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 418 rubles. Ihe analogue dị ọnụ ala site na 447 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 438 rubles. Ihe analogue dị ọnụ ala site na 427 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 604 rubles. Ihe analogue dị ọnụ ala site na 261 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 660 rubles. Ihe analogue dị ọnụ ala site na 205 rubles

    Dakọtara dị ka egosi

    Ọnụahịa ahụ sitere na 737 rubles. Ihe analogue dị ọnụ ala site na 128 rubles

    Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

    Mbadamba ihe mkpuchi acha odo odo, oblong, biconvex, nwere nsogbu.

















    Taabụ 1
    calcium rosuvastatin 10,5 mg
    nke kwekọrọ na ọdịnaya nke rosuvastatin 10 mg

    Ndị na-ahụ maka ihe: lactose monohydrate - 60 mg, microcrystalline cellulose - 45,4 mg, croscarmellose sodium - 1.2 mg, colloidal silicon dioxide - 600 μg, magnesium stearate - 2.4 mg.

    Ihe ndị mejupụtara ihe nkiri ahụ: hypromellose 2910/5 - 2.5 mg, macrogol 6000 - 400 μg, titanium dioxide - 325 μg, talc - 475 μg, iron dye na-acha ọbara ọbara - 13 μg.

    10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
    10 PC. - blisters (6) - ngwugwu nke kaadiboodu.
    10 PC. - blisters (9) - ngwugwu nke kaadiboodu.

    Omume ọgwụ

    Hypolip Ebola ọgwụ site na otu nke statins. Nhọrọ asọmpi ahọpụtara nke HMG-CoA reductase, enzyme nke na - agbanwe HMG-CoA ka mevalonate, ihe na - amalite cholesterol (Ch).

    Na - eme ka ọnụ ọgụgụ ndị na - anabata LDL nọ na hepatocytes, nke na - eduga n'ịbawanye ụba na catabolism nke LDL, na - egbochi mkpokọta VLDL, na - ebelata mkpokọta LDL na VLDL. Belata mkpokọta nke LDL-C, HDL cholesterol-na-abụghị lipoproteins (HDL-abụghị-HDL), HDL-V, Xc, TG, TG-VLDL, apolipoprotein B (ApoV), na-ebelata oke nke LDL-C / Lc-HDL, Xc / XL zuru HDL-C, Chs-abụghị HDL / Cs-HDL, ApoB / apolipoprotein A-1 (ApoA-1), na-eme ka ntinye uche nke Cs-HDL na ApoA-1 dịkwuo elu.

    Mpempe ume dị n’olu na-agbadata nha etu esi edere. Mmetụta ọgwụgwọ na-apụta n'ime izu 1 mgbe mmalite ọgwụgwọ, mgbe izu abụọ gachara 90% nke kachasị, rute oke site na izu anọ ma wee nọgide na-adịgide.

    Tebụl 1. Nsonaazụ dabere na ndị ọrịa nwere ọrịa hypercholesterolemia nke mbụ (ụdị IIa na IIb dịka nhazi nke Fredrickson) (nkezi mgbanwe mgbanwe pasent gbanwere ma e jiri ya tụnyere ọnụ ahịa mbụ)
















































































    Dose Onu ogugu ndi oria HS-LDL Nchikota Chs HS-HDL
    Ebe 13 -7 -5 3
    10 mg 17 -52 -36 14
    20 mg 17 -55 -40 8
    40 mg 18 -63 -46 10
    Dose Onu ogugu ndi oria TG Xc-
    abụghị HDL    		 Apo v Apo AI
    Ebe 13 -3 -7 -3 0
    10 mg 17 -10 -48 -42 4
    20 mg 17 -23 -51 -46 5
    40 mg 18 -28 -60 -54 0

    Tebụl 2. Nsonye obi dabere na ndị ọrịa nwere hypertriglyceridemia (ụdị IIb na nke IV dịka usoro Fredrickson si dị) (mgbanwe pasent ọkara na-emetụta uru mbụ)
















































































    Dose Onu ogugu ndi oria TG HS-LDL Nchikota Chs
    Ebe 26 1 5 1
    10 mg 23 -37 -45 -40
    20 mg 27 -37 -31 -34
    40 mg 25 -43 -43 -40
    Dose Onu ogugu ndi oria HS-HDL Xc-
    abụghị HDL    		 Xc-
    VLDL    		 TG-
    VLDL
    Ebe 26 -3 2 2 6
    10 mg 23 8 -49 -48 -39
    20 mg 27 22 -43 -49 -40
    40 mg 25 17 -51 -56 -48

    Igwu arụmọrụ

    Ọ dị irè na ndị okenye nwere hypercholesterolemia nwere ma ọ bụ na-enweghị hypertriglyceridemia, agbanyeghị agbụrụ, nwoke ma ọ bụ afọ, incl. n'ime ndị ọrịa nwere ọrịa mellitus na hypercholesterolemia nke ezinụlọ. Na 80% nke ndị ọrịa nwere ụdị IIa na IIb hypercholesterolemia (dị ka nhazi Fredrikon) na ntinye oge mbụ nke LDL-C gbasara 4.8 mmol / L, ebe ị na-a theụ ọgwụ ahụ na ọgwụ nke 10 mg, ịta LDL-C ruru erughị 3 mmol / L.

    N'ime ndị ọrịa nwere heterozygous familial hypercholesterolemia na-anata rosuvastatin na ọnụọgụ nke 20-80 mg / ụbọchị, a hụrụ mgbanwe dị mma nke profaịlụ anụ ahụ. Mgbe titicment kwa ụbọchị nke 40 mg (izu 12 nke ọgwụgwọ), mbelata mkpokọta LDL-C site na 53%. Na 33% ndị ọrịa, enwetara mkpokọta LDL-C nke erughị 3 mmol / L.

    N'ime ndị ọrịa nwere hypercholesterolemia na homozygous familial na-anata rosuvastatin na dose nke 20 mg na 40 mg, nkezi mbelata na ntinye uche nke LDL-C bụ 22%.

    N'ime ndị ọrịa nwere hypertriglyceridemia nke nwere ntụpọ mbụ nke TG site na 273 mg / dL ruo 817 mg / dL, na-anata rosuvastatin na usoro nke 5 mg ruo 40 mg 1 oge / ụbọchị maka izu isii, a na-agbadobekarị uche nke TG na plasma ọbara. )

    A na-ahụta mgbakwunye mmetụta na fenofibrate n'ihe metụtara mkpokọta nke TG yana nicotinic acid na doses lipid (karịa 1 g / ụbọchị) n'ihe metụtara ịta nke HDL-C.

    N'ime ọmụmụ METEOR, usoro ọgwụgwọ rosuvastatin belatara ngwangwa ọganihu nke ịdị obosara kachasị nke intima-media complex (TCIM) maka akụkụ 12 nke akwara carotid ma e jiri ya tụnyere placebo. E jiri ya tụnyere ụkpụrụ isi na rosuvastatin otu, mbelata TCIM kachasị site na 0.0014 mm / afọ ka atụnyere ihe mmụba nke ihe ngosi a site na 0.0131 mm / afọ na otu placebo. Ruo taa, egosighi mmekọrịta dị na etiti mbelata na TCIM na mbelata ihe ọghọm nke ihe omume obi.

    Nsonaazụ nke ihe omumu nke JUPITER gosipụtara na rosuvastatin belatara ihe egwu nke ibute ọrịa obi na mbelata ihe ọghọm 44%. Achọpụtara ịdị irè nke ọgwụ mgbe ọnwa isii mbụ nke ị .ụ ọgwụ ọjọọ. Enwere ọnụ ọgụgụ dị ịrịba ama nke ọnụego 48% gbakwunyere na nchịkọta, gụnyere ọnwụ site na ihe kpatara akwara obi, ọrịa strok na infarction, mbelata 54% na ihe ọgbụgba na-egbu egbu ma ọ bụ nke enweghị nna, yana mbelata 48% na ọrịa strok na-egbu egbu ma ọ bụ nke na-enweghị nna. N'ozuzu oke belatara site na 20% n'ime ndị otu rosuvastatin. Profaịlụ nchekwa na ndị ọrịa na-ewere rosuvastatin 20 mg n'ozuzu ha yiri profaịlụ nchekwa na otu placebo.

    Mlọ ọgwụ

    Mgbe ị takingụsịrị ọgwụ ahụ n’ime Cmax plasma rosuvastatin eruola n'ihe dị ka awa 5. Ọgwụ bioavailability zuru oke bụ ihe dịka 20%.

    Indmegide protein ndị dị na plasma (ọkachasị na albumin) bụ ihe dị ka 90%. Ised - 134 l.

    Rosuvastatin na-ewerekarị imeju, nke bụ nnukwu saịtị maka njikọta Chs na metabolism nke Chs-LDL.

    Penetrates site na ihe mgbochi placental.

    Biotransformed imeju na obere obere (ihe dị ka 10%), ịbụ onye na-abụghị mkpụrụ maka isoenzymes nke sistemụ cytochrome P450.

    Isi isoenzyme metụtara na metabolism nke rosuvastatin bụ isoenzyme CYP2C9. Isoenzymes CYP2C19, CYP3A4 na CYP2D6 etinyechaghị aka na metabolism.

    Ihe bụ isi metabolites nke rosuvastatin bụ N-dismethyl na lactone metabolites. N-dismethyl dị ihe dị ka 50% na-arụ ọrụ karịa rosuvastatin, metabolic lactone anaghị arụ ọrụ ọgwụ. Ihe karịrị 90% nke ọrụ ọgwụ na igbochi mgbasa HMG-CoA reductase bụ nke rosuvastatin na-enye, nke fọdụrụ bụ metabolites.

    Dị ka ọ dị n'ihe banyere ndị ọzọ na-egbochi HMG-CoA reductase, a na-ebu ọgwụ membrane a na-etinye aka na usoro nke iweghachi hepatic nke ọgwụ - polypeptide na-ebugharị anion Organic (OATP) 1B1, nke na-arụ ọrụ dị mkpa na mkpochapu hepatic ya.

    Ndi1/2 - ihe dị ka awa 19, anaghị agbanwe site na ịba ụba. Ibepu onyonyo plasma dị ihe dị ka 50 l / h (ọnụọgụ nke mgbanwe 21.7%). Ihe dị ka 90% nke rosuvastatin na-apụ apụ na-agbanwegharị site na eriri afọ, nke ọzọ site na akụrụ.

    Ihe ngosi usoro nke rosuvastatin na-abawanye na oke na nha.

    Usoro ọgwụ Pharmacokinetic adịghị agbanwe agbanwe na iji ya kwa ụbọchị.

    Pharmacokinetics n'ihe gbasara ọrịa

    N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ruo na nke dị ala, mkpokọta plasma nke rosuvastatin ma ọ bụ N-dysmethyl adịghị agbanwe nke ukwuu. N'ime ndị ọrịa nwere nnukwu akụrụ ụkọ (CC erughị 30 ml / min), ịta nke rosuvastatin na plasma ọbara dị okpukpu atọ, na N-dismethyl dị okpukpu 9 karịa nke ndị ọrụ afọ ofufo nwere ahụ ike. Ngwakọta plasma nke rosuvastatin dị na ndị ọrịa na hemodialysis ruru ihe dịka 50% karịa ndị ọrụ afọ ofufo ahụ siri ike.

    N'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ nke 7 isi ma ọ bụ belata na ọnụ ọgụgụ nke Child-Pugh, ọ nweghị ịrị elu na T1/2 rosuvastatin, n'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ 8 na 9 na ọnụ ọgụgụ nke Child-Pugh, a chọpụtara na elongation nke T1/2 Ugboro abụọ. Enweghị ahụmịhe banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere ọrụ imeju kachasị njọ.

    Okike nwoke na afọ anaghị enwe mmetụta dị ukwuu n’ụlọ ọgwụ na ọgwụ ọgwụ nke rosuvastatin.

    Thezọ ọgwụ ọgwụ nke rosuvastatin dabere na agbụrụ. AUC nke ndị nnọchi anya agbụrụ Mongoloid (Japanese, Chinese, Filipinos, Vietnam na Koreans) dị okpukpu 2 karịa nke agbụrụ Caucasian. Ndị India nkezi AUC na Cmax mụbara site na oge 1.3.

    Ndị na-egbochi HMG-CoA reductase, gụnyere rosuvastatin na - ejikọ ndị nchekwa ụgbọ njem OATP1B1 (polypeptide na - anion Organisation na - etinye aka na njigide hepatocyte nke statins) na BCRP (transpoxlu efflux). Ndị na-ebugharị ụdị genotypes SLCO1B1 (OATP1B1) s.521CC na ABCG2 (BCRP) s.421AA gosipụtara mmụba na mkpughe (AUC) na rosuvastatin 1.6 na oge 2.4, dị iche iche, ma e jiri ya tụnyere ndị na-ebugharị ụdị genotypes SLCO1B1 s.521TT na ABCG2 s.421CC.

    - isi hypercholesterolemia (ụdị IIa dị ka Fredrickson), gụnyere familial heterozygous hypercholesterolemia ma ọ bụ hypercholesterolemia agwakọta (ụdị IIb dị ka Fredrickson) - dị ka mgbakwunye na nri, mgbe nri na usoro ọgwụgwọ ndị ọzọ na-abụghị ọgwụ (dịka ọmụmaatụ, mmega ahụ, ibu ibu) ezughi oke.

    - ezinaụlọ hyzycholesterolemia - dị ka mgbakwunye maka nri na ọgwụ ndị ọzọ na - agbatị ume ọkụ (dịka ọmụmaatụ, LDL-apheresis), ma ọ bụ n'ọnọdụ ebe ụdị ọgwụgwọ ahụ anaghị arụ ọrụ nke ọma.

    - hypertriglyceridemia (ụdị nke IV dịka Fredrickson) - dị ka mgbakwunye na nri,

    - iji belata oganihu nke atherosclerosis - dika mgbakwunye na nri n’ime ndị ọrịa a gosipụtara ọgwụgwọ iji belata mkpokọta Chs na Chs-LDL,

    - mgbochi bụ isi nke nsogbu obi (ọrịa strok, nkụchi obi, ịtụgharị ụbụrụ) na ndị okenye n’enweghi akara ngosipụta akwara gbasara ọrịa akwara, mana o nwere oke mmụba nke mmepe ya (ihe karịrị afọ 50 afọ maka ụmụ nwoke na ihe karịrị afọ 60 maka ụmụ nwanyị, ịba ụba nke protein C-reactive protein. (≥ 2 mg / l) ma ọ dịkarịa ala otu n'ime ihe ndị ọzọ dị ize ndụ, dị ka ọbara mgbali elu, ntinye uche dị ala nke HDL-C, ise anwụrụ, akụkọ ezinụlọ nke mbido CHD).

    Usoro usoro onunu ogwu

    A na-ewere ọgwụ ọnụ. E kwesịrị ilo mbadamba dị iche iche, na-enweghị ịta ata ma ghara ịpịa ya mmiri, jiri mmiri saa ya n'oge ọ bụla n'ụbọchị, n'agbanyeghị nri ị na-eri.

    Tupu ịmalite ọgwụgwọ na Rosucard ®, onye ọrịa kwesịrị ịmalite ịgbaso usoro nri na-ebelata ume ma nọgide na-agbaso ya n'oge ọgwụgwọ.

    Ekwesịrị ịhọrọ dose nke ọgwụ ahụ n'otu n'otu dabere na ngosipụta na mmeghachi omume ọgwụgwọ, na-eburu n'uche nkwenye ndị a na-anabata ugbu a maka ị concentụ mkpụrụ ndụ lekwasịrị anya.

    Rosucard ® nke akwadoro ka akwadoro maka ndị ọrịa bidoro ị theụ ọgwụ, ma ọ bụ maka ndị ọrịa ebugharị na ịnara ndị ọzọ na-egbochi HMG-CoA reductase, bụ 5 ma ọ bụ 10 mg 1 oge / ụbọchị.

    Mgbe ị na-ahọrọ usoro ọgwụgwọ mbụ, mmadụ kwesịrị iduzi site na ọdịnaya cholesterol nke onye ọrịa na-eburu n'uche ihe ize ndụ nke ịmalite nsogbu ọrịa obi, ọ dịkwa mkpa iji chọpụta ihe egwu nwere ike ịme. Ọ bụrụ na ọ dị mkpa, ka izu anọ gachara ị canụ ọgwụ nwere ike ịba ụba.

    N'ihi mmepe omume enwere ike ị whenụ nsonaazụ mgbe ị na-a theụ ọgwụ ahụ na ọgwụ nke 40 mg, ma e jiri ya tụnyere obere usoro nke ọgwụ ahụ, mkpụrụedemede ikpeazụ maka ogo kachasị nke 40 mg kwesịrị ịme naanị naanị na ndị ọrịa nwere hypercholesterolemia na nnukwu nsogbu nke ọrịa obi (ọkachasị na ndị ọrịa site n'ọbara hypercholesterolemia), nke mgbe ị na-a theụ ọgwụ ahụ na ọgwụ nke 20 mg, emezughị ọkwa cholesterol. Ndị ọrịa dị otú a kwesịrị ịnọ n'okpuru nlekọta ahụike. A na-atụ aro iji nlezianya nyochaa ndị ọrịa na-anara ọgwụ ahụ na ọgwụ 40 mg.

    A naghị atụ aro ka a sụọ ọgwụ were 40 mg maka ndị ọrịa na-agabeghị dọkịta. Ka izu 2-4 gachara ọgwụgwọ na / ma ọ bụ mmụba na dose nke Rosucard ®, ọ dị mkpa iji nyochaa metabolism (mmezi dose dị mkpa ma ọ bụrụ na ọ dị mkpa).

    Na ndị ọrịa agadi kariri afọ 65 ekwesighi imeghari dose.

    Na ndị ọrịa nwere ọrịa imeju ya na ụkpụrụ n'okpuru isi asaa n'ihe gbasara -mụaka-Pugh ndozi nke Rosucard achoghi ya.

    Na ndị ọrịa nwere ọdịda obere ahandozi nke ogwu Rosucard drug achoghi ya, a na akwadoro uzo mbu nke 5 mg / day. Na ndị ọrịa nwere nnukwu nsogbu gbasara akụrụngwa (CC 30-60 ml / min) ị ofụ ọgwụ Rosucard ® na ọgwụ nke 40 mg / ụbọchị bụ contraindicated. Na nnukwu ọdịda gbasara akụrụngwa (CC na-erughị 30 ml / min) ọgwụ ọgwụ Rosucard ® na-emegide ọgwụ.

    Na Ọrịa nwere nkụda mmụọ ị ofụ ọgwụ Rosucard ® na ọgwụ nke 40 mg / ụbọchị bụ contraindicated. Mgbe ị na-ede ọgwụ ahụ na usoro onunu ogwu nke 10 mg na 20 mg / ụbọchị, usoro ọgwụgwọ akwadoro maka ìgwè ndị ọrịa a bụ 5 mg / ụbọchị.

    Mgbe ị na-agụ usoro ọgwụ ọgwụ ọgwụ rosuvastatin, mmụba na usoro nke ọgwụ ahụ na ndị nnọchi anya ama ama. Ọsọ Mongoloid. Ekwesiri iburu n'uche eziokwu a mgbe ị na-edegara ndị ọrịa agbụrụ Mongoloid Rosucard ®. Mgbe ị na-ede ọgwụ ahụ na usoro onunu ogwu nke 10 mg na 20 mg, usoro ọgwụgwọ akwadoro maka ìgwè ndị ọrịa a bụ 5 mg / ụbọchị. Mkpuchi ọgwụ Rosucard ® na 40 mg / ụbọchị na ndị nnọchi agbụrụ Mongoloid bụ contraindicated.

    Polymorphism mkpụrụ ndụ ihe nketa. Ndị na-ebugharị ụdị genotypes SLCO1B1 (OATP1B1) c.521CC na ABCG2 (BCRP) c.421AA gosipụtara mmụba na mkpughe (AUC) nke rosuvastatin ma e jiri ya tụnyere ndị na-ebugharị ụdị genotypes SLC01B1 s.521TT na ABCG2 s.421CC. Maka ndị ọrịa na-eburu genotypes c.521SS ma ọ bụ c.421AA, a tụrụ aro ka ukwuu nke Rosucard ® bụ 20 mg / ụbọchị.

    Usoro ọgwụgwọ na-ekwekọrịta. Rosuvastatin na - ejikọ nchekwa protein dị iche iche (ọkachasị, OATP1B1 na BCRP). Mgbe ejiri Rosucard ® ọgwụ mee ihe na ọgwụ (dịka cyclosporine, ụfọdụ ndị na-egbochi nje HIV, gụnyere njikọta nke ritonavir na atazanavir, lopinavir na / ma ọ bụ tipranavir), nke na-abawanye ịba ụba nke rosuvastatin na plasma ọbara n'ihi mmekọrịta nke protein nchebe, ihe ize ndụ nke myopathy nwere ike ịbawanye elu. (gụnyere rhabdomyolysis). N'ụdị ndị a, ị ga-elele ohere nke ịkọwa usoro ọgwụgwọ ọzọ ma ọ bụ kwụsịtụ iji Rosucard ®. Ọ bụrụ na iji ọgwụ ndị dị n'elu dị mkpa, ị kwesịrị ịmatara onwe gị na ntuziaka maka ị theụ ọgwụ ndị ahụ tupu ịkọwa ha n'otu oge na Rosucard evalu, nyochaa uru-ihe ga-aba uru nke ọgwụ concomitant ma lelee belata dose nke Rosucard ®.

    Mmetụta akụkụ

    Nsonaazụ ndị a chọpụtara na rosuvastatin na-adịkarị nwayọọ ma na-ahapụ naanị ha. Dịka ọ dị na ndị ọzọ na-egbochi HMG-CoA, ndị na - egbochi ndị mmadụ, ihe na - ebute nsonaazụ ya bụ nke ukwuu dabere.

    N'okpuru ebe a bu profaịlụ nke mmeghachi omume na-adịghị mma maka rosuvastatin, dabere na data sitere na ọmụmụ ụlọ ọgwụ na ahụmịhe post ọ bụla.

    Mkpebi ugboro ole mmeghachi omume ọjọọ (nhazi ọkwa WHO): ọtụtụ mgbe (> 1/10), ọtụtụ mgbe (site na> 1/100 ruo 1/1000 ruo 1/10 000 ruo 20 mg / ụbọchị), adịkarịghị - ọrịa ogbu na nkwonkwo, akwara obi, nwere ike iji ya Ọkpụkpụ akaị, oge amaghị ihe - immuno-mediated necrotizing myopathy.

    Mmeghachi omume nfụkasị ahụ: ugboro ugboro - isi awọ, urticaria, ihe ngbu, adịkarịghị - mmeghachi omume hypersensitivity, gụnyere angioedema.

    Na akpụkpọ anụ ahụ ugboro-amaghị - Stevens-Johnson ọrịa.

    Site na urinary system: ọtụtụ mgbe - proteinuria, adịkarịghị ala - hematuria. A na-achọpụta mgbanwe na ọnya protein dị na mmamịrị (site na ọnụnọ ma ọ bụ ọnụọgụ dị ka ++ ma ọ bụ karịa) na ihe na-erughị 1% nke ndị ọrịa na-anata ọgwụ 10-20 mg / ụbọchị, na ihe dị ka 3% nke ndị ọrịa na-anata 40 mg / ụbọchị. Proteinuria na-ebelata n'oge usoro ọgwụgwọ yana ọ nweghị ihe jikọrọ ya na ọrịa akụrụ ma ọ bụ ọrịa ọnya.

    Site na mkpụrụ ndụ ihe nketa na mammary gland: o siri ike - gynecomastia.

    Nnyocha ụlọ nyocha: ugboro ugboro - mmụba dabere na ọrụ CPK serum (n'ọtụtụ oge, adịghị mkpa, asymptomatic na nwa oge). Site na mmụba nke ihe karịrị ugboro ise ma e jiri ya tụnyere VGN, ekwesịrị ịkwụsịtụ ọgwụgwọ na Rosucard ® nwa oge. Plaba ụba ịba uru nke ọbara gemocolobin plasma.

    Ndị ọzọ: ọtụtụ mgbe - asthenia, ugboro ole amaghi ama - akụkụ ụsọ.

    Mgbe ị na-eji Rosucard ®, achọpụtara mgbanwe na paradaịs ndị a: mmụba nke mkpokọta glucose, bilirubin, ọrụ alkaline phosphatase, na GGT.

    Akuko mmepe nke ihe ndia di otua ka etinyere n'oge eji ihe aru di iche: oria erectile, nsogbu nke oria akpa obi (karie ya ka o jiri ogologo oge), oria oria oria obi uto nke okpukpu 2, onodu ogha n’iru nke nke dabere n’onodu ma obu enwebeghi ihe ndi puru ime ihe (igba obubu glucose ọbara 5.6- 6.9 mmol / l, BMI> 30 n'arọ / m 2, hypertriglyceridemia, akụkọ ihe mere eme nke ọbara mgbali elu).

    Ihe ngbanwe

    Maka mbadamba 10 na 20 mg

    - Hypersensitivity na mmiri ọgwụ,

    - ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba na-arụ ọrụ nke transminates hepatic na ọbara (ihe karịrị ugboro atọ ma e jiri ya tụnyere VGN) nke sitere na mmalite amabeghị

    - imeju imeju (ogo site na asaa ruo isi iteghete na nwatakiri-Pugh)

    - mmụba na mkpokọta nke CPK n'ime ọbara karịa ugboro ise ma e jiri ya tụnyere VGN,

    - dysfunction siri ike gbasara akụrụngwa (CC na-erughị 30 ml / min),

    - ndị ọrịa tụbara mmepe nke nsogbu myotoxic,

    - nchịkwa nke cyclosporine,

    - ejikọtara ya na ndị na - egbochi nje HIV

    - ọrịa ndị a kpụrụ eketa, dị ka ekweghị ekwe nke lactose, ụkọ lactase ma ọ bụ glucose-galactose malabsorption (n'ihi ọnụnọ nke lactose na ihe mejupụtara),

    - womenmụ nwanyị dị afọ imu na-adịghị eji ụzọ zuru oke nke igbochi afọ ime,

    - lactation (inye ara),

    - gbara afọ 18 (agbadobeghị ịdị irè na nchekwa),

    Maka mbadamba 40 mg (na mgbakwunye contraindications maka mbadamba 10 na 20 mg)

    Ọnụnọ nke ihe ndị a dị egwu maka mmepe nke myopathy / rhabdomyolysis:

    - myotoxicity megide ndabere nke iji ndị ọzọ na - egbochi HMG-CoA reductase ma ọ bụ fibrates na akụkọ ntolite,

    - nsogbu akwara nke ogo oke (CC 30-60 ml / min),

    ị consumptionụbiga mmanya ókè,

    - ọnọdụ ndị nwere ike iduga n'ịba ụba na mkpokọta plasma nke rosuvastatin,

    - nnabata n'otu oge.

    Ndị ọrịa nke agbụrụ Mongoloid.

    Ihe ngosiputa oria akwara na akuko ezinulo.

    Maka mbadamba 10 na 20 mg: nwere akụkọ banyere ọrịa imeju, sepsis, hypotension, nnukwu ịwa ahụ, trauma, metabolic siri ike, endocrine ma ọ bụ ọgba aghara aghara, enweghị njide na-adịghị mma, yana iji obere mmebi akwara, hypothyroidism, na iji ihe ndị ọzọ HMG-CoA reductase inhibitors ma ọ bụ fibrates, ihe ngosiputa nke akuko aru nke aru aru, oria akwara bu na ihe ana eme, ya na ochichi nke ime ya, ihe ndi n’enwe onu ogugu. na rosuvastatin ọbara plasma na ọrịa afọ karịrị afọ 65, ndị Mongoloid agbụrụ ọrịa na Oké mmanya.

    Maka mbadamba 40 mg: nwere ọdịda akụrụngwa dị nro (CC karịa 60 ml / min), akụkọ ihe mere eme nke ọrịa imeju, sepsis, hypotension, oke ịwa ahụ, mmerụ ahụ, metabolic siri ike, endocrine ma ọ bụ ọgba aghara electrolyte, ọdịdọ a na-achịkwaghị achịkwa, na ndị ọrịa karịa afọ 65.

    Ime na lactation

    Rosucard ® bụ nke dị ime n’oge na imebe nwa (inye ya ara).

    Ojiji Rosucard ® ụmụ nwanyị gbara afọọ ga - ekwe omume naanị ma ọ bụrụ na ejiri usoro mgbochi ndị a pụrụ ịdabere na ya mee ihe ma ọ bụrụ na a gwa onye ọrịa banyere ihe nwere ike ịnwe ọgwụgwọ nke nwa ebu n’afọ.

    Ebe o bu na cholesterol na ihe ndi choputara n’ime cholesterol di nkpa maka mmepe nwa ebu n’onu, ihe ọghọm nke igbochi HMG-CoA mbelata ga-erite uru nke iji ọgwụ n’oge afọ ime. Ọ bụrụ n’ịchọpụta afọ ime n’oge iji ọgwụ agwọ ọgwụ, Rosucard ® kwesịrị ịkwụsị ozugbo, e kwesịrị ịdọ onye ọrịa aka na ntị gbasara ihe nwere ike ibute nwa ebu n’afọ.

    Ọ bụrụ na ọ dị mkpa iji ọgwụ mee ihe n'oge a na-enye nwa ara, nyere ohere nke ihe omume ọjọọ na ụmụ ọhụrụ, a ga-eleba anya n'okwu banyere ịkwụsị inye ụmụ ara.

    Ntụziaka pụrụ iche

    Mmetụta akụrụ

    N'ime ndị ọrịa na-anata oke ọgwụ rosuvastatin (ọkachasị 40 mg), a hụrụ protein tubular proteinuria, nke n'ọtụtụ ọnọdụ dị obere. Proteindị proteinuria ahụ egosighi ọrịa akụrụ nnukwu ma ọ bụ ọrịa ọrịa akụrụ. N'ime ndị ọrịa na-a theụ ọgwụ ahụ na ọgwụ 40 mg, a na-atụ aro ka nyochaa ndị na-egosi ọrụ akụrụ mgbe ọgwụgwọ.

    Mmetụta n’usoro mọzụlụ

    Mgbe ị na-eji rosuvastatin na usoro onyonyo niile, na ọkachasị na usoro nke ihe karịrị 20 mg, a kọpụtara mmetụta ndị a na sistemụ akwara: myalgia, myopathy, n'ọnọdụ ndị a na-adịghị ahụkebe, rhabdomyolysis.

    Mkpebi nke ọrụ CPK

    Mkpebi ihe omume CPK ekwesighi ime mgbe mgbatị ahụ siri ike ma ọ bụ ọnụnọ nke ebumnuche ndị ọzọ enwere ike maka mmụba na ọrụ CPK, nke nwere ike ibute nkọwa na-ezighi ezi banyere nsonaazụ ahụ. Ọ bụrụ na ọrụ mbụ nke CPK na-abawanye ụba (5 ugboro karịa VGN), mgbe ụbọchị 5-7 gasịrị, a ga-ebu ụzọ tụọ nke abụọ. Agaghị amalite usoro ọgwụgwọ ahụ ma ọ bụrụ na nnwale ọzọ na-akwado ọrụ mbụ nke KFK (karịa ugboro ise karịa VGN).

    Tupu ịmalite usoro ọgwụgwọ

    Mgbe ị na-eji Rosucard ®, yana mgbe ị na-eji ndị ọzọ HMG-CoA reductase inhibitors, ọ kwesịrị ịkpachara anya na ndị ọrịa nwere ihe ndị dị adị maka myopathy / rhabdomyolysis. Ekwesịrị ịtụle oke uru ihe ọghọm ga-enyocha, ma ọ bụrụ na ọ dị mkpa, ekwesịrị ileba anya nyocha nke onye ọrịa n'oge ọgwụgwọ.

    N'oge ọgwụgwọ

    Gwa onye ọrịa banyere mkpa ọ dị ịgwa dọkịta ozugbo ozugbo banyere nsogbu mgbu mgbu, ike ọgwụgwụ ma ọ bụ ịkpa oke, ọkachasị yana ịba na ahụ ọkụ. N'ime ndị ọrịa dị otú ahụ, ekwesịrị ikpebi ọrụ CPK. Usoro ọgwụgwọ a ga-akwụsị ma ọ bụrụ na ọrụ CPK abawanye ụba (karịa ugboro ise karịa VGN) ma ọ bụ ọ bụrụ na a na-ekwupụta ihe mgbaàmà n'akụkụ akụkụ nke akwara ma kpatara ọgba aghara kwa ụbọchị (ọbụlagodi na ọrụ KFK erughị 5 ugboro ma e jiri ya tụnyere VGN). Ọ bụrụ na mgbaàmà akwụsị, ma rụọ ọrụ CPK laghachi na nkịtị, ekwesịrị ịtụleghachi idegharị Rosucard ® ma ọ bụ ihe ndị ọzọ HMG-CoA reductase inhibitors na obere usoro na iji nlezianya nyochaa onye ọrịa.

    Usoro nlekọta nke usoro CPK na-enweghị ihe mgbaàmà adịghị arụ ọrụ. Ebube dịkarịsịrị njọ nke nje na-agbachitere myopathy na ngosipụta akparamaagwa n'ụdị nke adịghị ike nke proximal na mmụba nke ọrụ nke CPK n'ọbara ọbara n'oge ọgwụgwọ ma ọ bụ mgbe a na-ewere statins, gụnyere rosuvastatin. Ọmụmụ ihe ndị ọzọ gbasara akwara na akwara, ọmụmụ serological, yana ọgwụ immunosuppressive nwere ike ịchọ. Enweghị akara nke mmụba ọ bụla na akwara ọkpụkpụ mgbe ị na-ewere rosuvastatin na ọgwụgwọ concomitant. Agbanyeghị, a kọọrọ mmụba nke myositis na myopathy na ndị ọrịa na-ewere ọgwụ mgbochi HMG-CoA reductase ndị ọzọ na mgbakwunye fibric acid, gụnyere gemfibrozil, cyclosporine, nicotinic acid na usoro onyonyo ọbara (karịa 1 g / ụbọchị), ndị na-ahụ maka ọgwụ mgbochi azole, inhibitors Ọrịa nje HIV na ọgwụ nje macrolide. Gemfibrozil na-abawanye ohere nke myopathy mgbe ejiri ya na ụfọdụ HMG-CoA reductase inhibitors. Yabụ, akwadoghị iji ọgwụ Rosucard ® na gemfibrozil n'otu oge ahụ. E kwesịrị iji nlezianya tụọ oke ihe ọghọm na uru ọghọm dị mgbe ejiri rosucard ® yana fibrates ma ọ bụ usoro hypolipPs nke nicotinic acid. Amalite ị ofụ ọgwụ Rosucard ® na dose nke 40 mg yana fibrates. Izu iri abụọ na anọ mgbe mmalite nke ọgwụgwọ na / ma ọ bụ mmụba na dose nke Rosucard ®, nlebara anya metabolism dị mkpa (mmezi dose dị mkpa ma ọ bụrụ na ọ dị mkpa).

    A na-atụ aro ikpebi ihe ndị na-egosi ọrụ imeju tupu ịmalite ọgwụgwọ yana ọnwa atọ ka mmalite ọgwụgwọ. A ga-akwụsị iji ojiji Rosucard drug nke ọgwụ ahụ ma ọ bụ belata ọgwụ nke ọgwụ ahụ ma ọ bụrụ na ọrụ hepatic transaminases na plasma ọbara dị okpukpu atọ karịa VGN.

    N'ime ndị ọrịa nwere hypercholesterolemia n'ihi hypothyroidism ma ọ bụ ọrịa nephrotic, a ga-ebu ụzọ gwọọ ọrịa ndị isi tupu a gwọọ Rosucard ®.

    Ndị na-egbochi nje HIV

    Agaghị akwadoro ị theụ ọgwụ Rosucard ® yana ndị na - egbochi nje HIV.

    Ọrịa ngụgụ

    Mgbe ị na-eji ihe ụfọdụ akpụrụ akpụ, ọ kachasị, ogologo oge, kọọrọ ndị dịpụrụ adịpụ nke ọrịa ngụgụ. Ihe ngosiputa oria a nwere ike itinye mkpirisi iku ume, ukwara nke n’adighi eme, yana odi mma n’adighi ike (adighi ike, ibu na ahu oku). Ọ bụrụ na ị na-enyo enyo na ọrịa nku ume intrstitial, ọ dị mkpa ịkwụsị ọgwụgwọ ya na Rosucard ®.

    Ọrịa shuga 2dị 2

    Ọgwụ Statin nwere ike ime ka mmụba nke glucose n'ọbara. N'ime ụfọdụ ndị ọrịa nwere nnukwu ọrịa nke ịmalite ọrịa mellitus nke ọrịa shuga, mgbanwe ndị dị otú ahụ nwere ike iduga na ngosipụta ya, nke bụ ihe ngosipụta maka nhọpụta hypoglycemic ọgwụgwọ. Agbanyeghị, mbelata ihe ọghọm nke ọrịa vaskụla na akpụ akpụ na - ebulite ohere nke ịmalite ọrịa mellitus, yabụ, ihe a ekwesịghị ịbụ ihe ndabere maka ịkagbu ọgwụgwọ statin. Ndị ọrịa nọ n'ihe ize ndụ (na-ebu ọnụ nke glucose ọbara nke 5.6-6.9 mmol / L, BMI> 30 n'arọ / m 2, akụkọ ihe mere eme nke hypertriglyceridemia, na ọbara mgbali elu) kwesịrị ịta ahụike na nlele mgbe niile nke ọgwụ kemịkalị.

    Ekwesighi iji Rosucard ® mee ihe na ndị ọrịa nwere ụkọ lactase, enweghị nkwekọrịta galactose na glucose-galactose malabsorption.

    N'ime usoro ọmụmụ ọgwụ pharmacookinetic n'etiti ndị ọrịa China na ndị Japan, a chọpụtara mmụba nke usoro nke rosuvastatin ma e jiri ya gosipụta akara ndị a nwetara n'etiti ndị ọrịa agbụrụ Caucasian.

    Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

    Ekwesịrị ịkpachara anya mgbe ị na-anya ụgbọala na ihe omume ndị chọrọ ịbawanye ụba nke nlebara anya na ọsọ nke mmeghachi omume psychomotor (iwe nwere ike ime n'oge ọgwụgwọ).

    Dodoụbiga ya ókè

    Site na nhazi nke oge a ọtụtụ ọgwụ kwa ụbọchị, usoro ọgwụ ọgwụ nke rosuvastatin adịghị agbanwe.

    Ọgwụgwọ: enweghi ọgwụgwọ a kapịrị ọnụ, a na-eme ọgwụgwọ symptomatic iji lekọta ọrụ nke akụkụ ahụ na sistem dị mkpa. Ọ dị mkpa iji nyochaa ndị na-egosi ọrụ imeju yana ọrụ CPK. Ọkpụkpụ anụ ahụ adịghị arụ ọrụ.

    Mkparịta ụka ọgwụ ọjọọ

    Mmetụta nke ọgwụ ndị ọzọ na rosuvastatin

    Ndị na-egbochi protein na-ebugharị: rosuvastatin na-ejikọ ụfọdụ protein na-ebu njem, ọkachasị OATP1B1 na BCRP.Enwere ike ijikọ ọnụ nke ọgwụ ndị na-ebupu protein na-egbochi protein na rosuvastatin na plasma ọbara na ohere dị elu nke myopathy (lee okpokoro 3).

    Cyclosporin: n'iji rosuvastatin na cyclosporine na-eme n'otu oge, AUC nke rosuvastatin nọ nkezi nke asaa karịa nke a hụrụ na ndị ọrụ afọ ofufo nwere ahụ ike. Ọdịghị emetụta mkpụkọ plasma nke cyclosporine. Rosuvastatin na contraindicated na ndị ọrịa na-ewere cyclosporine.

    Ndị na-egbochi nje HIV ọ bụ ezie na amabeghị usoro a ga-esi na-emekọ ihe ọnụ, iji jikọtara ndị na-egbochi nje HIV na-ebute nchebe nwere ike ibute mmụba dị ukwuu na mkpughe nke rosuvastatin (lee table 3) Ọmụmụ ọgwụ pharmacokinetic maka ojiji nke rosuvastatin n’otu oge 20 mg yana nkwadebe nkwanye nwere ihe abụọ na-egbochi nje HIV (400 mg nke lopinavir / 100 mg nke ritonavir) na ndị ọrụ afọ ofufo siri ike dugara na mkpokọta okpukpu abụọ na okpukpu ise na AUC0-24) na Cmax rosuvastatin, otu. Yabụ, ịnaghị eji ọgwụ Rosucard ® yana ndị na - egbochi nje HIV na - egbochi n'otu oge (lee okpokoro 3).

    Gemfibrozil na ọgwụ ndị ọzọ na-eweta mmachi: ijikọtara rosuvastatin na gemfibrozil na-eduga na mmụba okpukpu abụọ na Cmax na AUC nke rosuvastatin. Dabere na data gbasara mmekorita ndị akọwapụtara, anaghị atụ anya mmekọrịta dị n'etiti ọgwụ na fenofibrate, enwere ike ịmekọrịta ọgwụ ọgwụ. Gemfibrozil, fenofibrate, fibrates ndị ọzọ, na nicotinic acid dị na usoro egbugbere egbugbere ọnụ (karịa 1 g / ụbọchị) na-amụba ohere nke myopathy mgbe ejiri ya na HMG-CoA reductase inhibitors, ikekwe n'ihi eziokwu ahụ na ha nwere ike ibute myopathy mgbe ejiri ya ka monotherapy. Mgbe ị na-a theụ ọgwụ ahụ na gemfibrozil, fibrates, acid nicotinic na lipid wedates, a na-atụ aro ka ndị ọrịa nwee ọgwụ mbụ Rosucard ® 5 mg, a na-egbochi 40 mg na njikọta ya na fibrates.

    Fusidic acid: Enwebeghị nnyocha dị iche iche emere na mmekọrịta ọgwụ nke fusidic acid na rosuvastatin, mana enwere akụkọ dị iche iche nke ikpe rhabdomyolysis.

    Ezetimibe: n'otu oge ọgwụ Rosucard ® na ọgwụ nke 10 mg na ezetimibe na dose nke 10 mg yana mgbakwunye na AUC nke rosuvastatin na ndị ọrịa nwere hypercholesterolemia (lee okpokoro 3). Ọ gaghị ekwe omume iwepu ohere dị ukwuu nke nsonaazụ ya na mmekọrịta ya na ọgwụ Rosucard ® na ezetimibe.

    Erythromycin: ojiji a na-ejigha rosuvastatin na erythromycin na-eduga na mbelata na AUC(0-t) 20% rosuvastatin na Cmax rosuvastatin 30%. Mkparịta ụka dị otú a nwere ike ịba ụba n'ihi mgbatị ụbụrụ na-akpata site na ị eụ erythromycin.

    Antacids: n'otu oge eji rosuvastatin na mgbochi nke antacids nwere alumini ma ọ bụ magnesium hydroxide, na-eduga na mbelata plasuma nke rosuvastatin ihe dị ka 50%. Agaghị ekwupụta mmetụta a ma ọ bụrụ na ejiri antacids awa 2 awa mgbe ị roụsịrị rosuvastatin. Emebeghị ka amuta ihe banyere ulo ogwu a.

    Isoenzymes nke usoro cytochrome P450: Na nyocha vivo na inyocha egosila na rosuvastatin abughi ihe mgbochi ma ọ bụ onye na - eke cytochrome P450 isoenzymes. Na mgbakwunye, rosuvastatin bụ mkpụrụ na-adịghị ike maka enzyme ndị a. Ya mere, mmekorita nke rosuvastatin na ọgwụ ndị ọzọ na ọkwa metabolic metụtara cytochrome P450 isoenzymes anaghị atụ anya. Enweghị mmekọrịta dị egwu dị n'etiti rosuvastatin na fluconazole (onye na-egbochi isoenzymes CYP2C9 na CYP3A4) na ketoconazole (onye na-egbochi isoenzymes CYP2A6 na CYP3A4).

    Mmekorita ya na ogwu nke choro ndozi nke rosuvastatin (lee okpokoro 3)

    O kwesiri imeghari uzo nke rosuvastatin ma oburu na odi nkpa, ojiji ejikọtara ya na ogwu nke na-abawanye ikpughe nke rosuvastatin. Ọ bụrụ na a na-atụ anya mmụba nke oge 2 ma ọ bụ karịa, usoro mbụ nke Rosucard ® kwesịrị ịbụ 5 mg 1 oge / ụbọchị. Ikwesiri imeghari uzo kachasi anya nke Rosucard ® ka ihe ntughari bu rosuvastatin ghara gafere nke a maka 40 mg ewere ya n’enweghi nsogbu nke ogwu n’aruba rosuvastatin. Dịka ọmụmaatụ, oke rosuvastatin kachasị elu kwa ụbọchị na iji gemfibrozil bụ 20 mg (mmụba na mkpughe site na oge 1.9), ya na ritonavir / atazanavir - 10 mg (mmụba na mkpughe bụ ugboro 3.1).

    Tebụl 3. Mmetụta nke ọgwụ concomitant na mkpughe nke rosuvastatin (AUC, egosiri data na-agbadata n'usoro) - nsonaazụ nke ọnwụnwa ụlọ ọgwụ bipụtara.



















































































































    Usoro ọgwụgwọ nkwanye ùgwù Usoro nchịkwa Rosuvastatin Mgbanwe AUC na rosuvastatin
    Cyclosporin 75-200 mg ugboro abụọ / ụbọchị, ọnwa 6 10 mg 1 oge / ụbọchị, 10 ụbọchị Npita 7.1x
    Atazanavir 300 mg / ritonavir 100 mg 1 oge / ụbọchị, ụbọchị 8 10 mg otu dose Mmụba 3.1x
    Simeprevir 150 mg 1 oge / ụbọchị, 7 ụbọchị 10 mg otu dose Ịdị elu 2.8x
    Lopinavir 400 mg / ritonavir 100 mg 2 ugboro / ụbọchị, ụbọchị 17 20 mg 1 oge / ụbọchị, 7 ụbọchị Mmụba 2.1x
    Clopidogrel 300 mg (nke na-ebu ibu), mgbe ahụ, 75 mg mgbe awa 24 gachara 20 mg otu dose Mmụba 2x
    Gemfibrozil 600 mg ugboro abụọ / ụbọchị, 7 ụbọchị 80 mg otu dose Npita 1.9x
    Eltrombopag 75 mg 1 oge / ụbọchị, 10 ụbọchị 10 mg otu dose Npita 1.6x
    Darunavir 600 mg / ritonavir 100 mg 2 ugboro / ụbọchị, ụbọchị 7 10 mg 1 oge / ụbọchị, 7 ụbọchị Oge 1.5 na-abawanye
    Tipranavir 500 mg / ritonavir 200 mg 2 ugboro / ụbọchị, ụbọchị 11 10 mg otu dose Oge 1.4 na-abawanye
    Dronedarone 400 mg ugboro abụọ / ụbọchị Enweghị data Oge 1.4 na-abawanye
    Itraconazole 200 mg 1 oge / ụbọchị, 5 ụbọchị 10 mg ma ọ bụ 80 mg otu ugboro Oge 1.4 na-abawanye
    Ezetimibe 10 mg 1 oge / ụbọchị, 14 ụbọchị 10 mg 1 oge / ụbọchị, 14 ụbọchị Npita 1.2x
    Fosamprenavir 700 mg / ritonavir 100 mg ugboro abụọ / ụbọchị, ụbọchị 8 10 mg otu dose Enweghị mgbanwe
    Aleglitazar 0.3 mg, 7 ụbọchị 40 mg, 7 ụbọchị Enweghị mgbanwe
    Silymarin 140 mg ugboro 3 / ụbọchị, 5 ụbọchị 10 mg otu dose Enweghị mgbanwe
    Fenofibrate 67 mg ugboro atọ / ụbọchị, 7 ụbọchị 10 mg, 7 ụbọchị Enweghị mgbanwe
    Rifampin 450 mg 1 oge / ụbọchị, 7 ụbọchị 20 mg otu dose Enweghị mgbanwe
    Ketoconazole 200 mg ugboro abụọ / ụbọchị, ụbọchị 7 80 mg otu dose Enweghị mgbanwe
    Fluconazole 200 mg 1 oge / ụbọchị, 11 ụbọchị 80 mg otu dose Enweghị mgbanwe
    Erythromycin 500 mg 4 ugboro / ụbọchị, 7 ụbọchị 80 mg otu dose Mbelata 28%
    Baikalin 50 mg ugboro 3 / ụbọchị, 14 ụbọchị 20 mg otu dose Mbelata 47%

    Nsonaazụ nke rosuvastatin na ọgwụ ndị ọzọ

    Vitamin K Antagonists: ịmalite ọgwụgwọ rosuvastatin ma ọ bụ ịba ụba nke rosuvastatin na ndị ọrịa na-anata antagonists vitamin K n'otu oge (dịka ọmụmaatụ, warfarin ma ọ bụ ọgwụ anticoagulants ndị ọzọ) nwere ike ibute mmụba na INR. Celkagbu ma ọ bụ mbelata dose Rosucard ® nwere ike ibute INR. N'ụdị ndị ahụ, a na-atụ aro njikwa INR.

    Ogwu ogwu mgbochi ogwu / holomon nke ogwu:n'otu oge eji rosuvastatin na ọgwụ mgbochi ọnụ na-eme ka AUC nke ethinyl estradiol na AUC nke norgestrel dị 26% na 34%, n'otu n'otu. Ekwesịrị iburu ụdị mgbakwunye plasma a n'uche mgbe ị na-ahọrọ ọgwụ mgbochi ọgwụ a ga-aralụ.

    Enweghị data ọgwụ ọgwụ gbasara ojiji nke rosuvastatin na ọgwụ nnọchi homonụ. Agaghị enwe ike ịhapụ mmetụta yiri ya na ojiji nke rosuvastatin na ọgwụgwọ nnọchi homonụ. Agbanyeghị, ejikọtara ngwakọta a n'ọtụtụ oge ule ụlọ ọgwụ yana ndị ọrịa nabatara ya nke ọma.

    Ọgwụ ndị ọzọ: Enweghị mmekọrịta dị n'etiti rosuvastatin na digoxin na-atụ anya.

    Pharmacodynamics na pharmacokinetics

    Rosucard bụ otu akpụ. Ọ na-egbochi ya HMG-CoA reductase - enzyme nke tụgharịrị GMG-CoA n'ime mevalonate.

    Na mgbakwunye, ngwá ọrụ a na-abawanye ọnụ ọgụgụ nke Ndị na-anabata LDL na hepatocytesna - eme ka catabolism na ijide mmadụ sie ike LDL ma na-akpata mgbochi mgbochi VLDLna -ebelata ọdịnaya niile VLDL na LDL. Ọgwụ na-ebelata ịta HS-LDL, ọnụọgụ dị elu nke cholesterol na-abụghị lipoprotein, HS-VLDLP, TG, apolipoprotein B, TG-VLDLP, mkpokọta xc, ma na-abawanye ọdịnaya ApoA-1 na HS-HDL. Na mgbakwunye, ọ na-ebelata oke ApoVna ApoA-1, HS-abụghị HDL na HS-HDL, HS-LDL na HS-HDL, mkpokọta xc na HS-HDL.

    Isi mmetụta nke Rosucard bụ otu dabara adaba etu esi eme ya. A na-ahụta ọgwụgwọ ọgwụgwọ mgbe mmalite ọgwụgwọ gwọchara ya mgbe otu izu gachara, ihe dị ka otu ọnwa ọ kacha karịa, emesịa ọ na-ewusi ike ma na-adịgide.

    A na-ehibe oke kachasị nke ihe dị n'ọrụ na plasma mgbe elekere ise gachara. Edozi bioavailability mejuputara 20%. Ogo nke njikọ ya na protein plasma ọbara dị ihe dịka 90%.

    Site n'iji ya eme ihe mgbe nile, ọgwụ pharmokokinetics adịghị agbanwe.

    Metabolized Rosucard site na imeju. Penetrates ọma ihe mgbochi plas. Isi metabolites – N-dismethyl na metabolites lactone.

    Ọkara ndụ bụ ihe dịka awa iri na itoolu, ebe ọ naghị agbanwe agbanwe ma ọ bụrụ na ịba ụba usoro ọgwụ a. Ibepu ahihia na nkezi - 50 l / h. Ihe dị ka 90% nke ihe arụ ọrụ ka ewepụrụ site na eriri afọ na-agbanweghi, nke fọdụrụ site na akụrụ.

    Mmekọahụ na afọ anaghị emetụta ọgwụ ọgwụ nke Rosucard. Agbanyeghị, ọ dabere n'ọsọ. Ndị India nwere ntinye uche na nkezi Auc Oge 1.3 dị elu karịa agbụrụ ndị Caucasian. Aucn'ime ndị agbụrụ Mongoloid, ugboro abụọ karịa.

    Ihe ngosi maka iji Rosucard

    Ihe ngosi maka ojiji nke Rosucard bu ndi a:

    • isi hypercholesterolemia ma ọ bụ agwakọta dyslipidemia A na - eji ọgwụ eme ihe dị ka mgbakwunye na nri ahụ ma ọ bụrụ na nri anaghị edozi ezumike,
    • mkpa igbochi mmepe atherosclerosis A na - eji ọgwụ ahụ eme ihe dị ka mgbakwunye maka nri dịka akụkụ nke ọgwụgwọ iji belata ọkwa mkpokọta cholesterol na Cholesterol ka ọnụego nkịtị
    • ezinụlọ hypercholesterolemia homozygous - eji ọgwụ eme ihe dị ka mgbakwunye na nri ma ọ bụ dịka akụrụngwa egbugbere ọgwụ
    • mkpa ọ dị maka igbochi ihe mgbagwoju anya na arụ ọrụ nke akụrụngwa akụrụngwa nwere ihe ọghọm nke ịdabaatherosclerotic Ọrịa obi - ejiri ọgwụ ahụ mee ihe dịka akụkụ ọgwụgwọ.

    Nsonaazụ

    Mmeghachi omume ọjọọ site na iji ọgwụ nwere ike ịdị ka ndị a:

    • sistemụ ụjọ: isi ọwụwa, ọrịa asthenic, anya ntughari,
    • usoro iku ume: ụkwara, dyspnea,
    • sistem: myalgia,
    • anụ ahụ na akpụkpọ anụ subcutaneous: nsogbu ịla azụ, Stevens-Johnson ọrịa,
    • ndị na-egosi ụlọ nyocha: mmụba dị mkpirikpi na ọrụ ọbara CPK dabere na usoro onunu ogwu
    • mmeghachi omume nfụkasị ahụ: itching, urticariaihe odide
    • Usoro nri: ọgbụgbọ, mgbu afọ, afọ ntachivomiting afọ ọsịsa,
    • usoro endocrine: ụdị shuga II,
    • Usoro urinary: proteinuriaurinary tract na-efe efe.

    N'oge ụfọdụ, enwere ike nsogbu neuropathy akụkụ, ọria arunchetaịba ọcha n'anya, jaundice, myopathy, rhabdomyolysis, angioedema, hematuria, odika abawanye Ọrụ AST na ALT.

    Mmekorita

    Cyclosporin yana rosucard na abawanye uru ya Auc ihe dịka ugboro asaa. Iri ihe kariri 5 mg akwadoro.

    Gemfibrozilna ndị ọzọ ịbelata ike ọgwụ na yana rosucard na-ebute mmụba na ịta ya kachasị na Auc ihe dị ka ugboro abụọ. Ihe egwu nke myopathies. Oke kachasị mgbe ejiri ya Gemfibrozil - 20 mg. Mgbe gị na ya na-emekọ ihe fibrates Anabataghị usoro ị drugụ ọgwụ ahụ na 40 mg, usoro izizi bụ 5 mg.

    Mkparịta ụka ọgwụ ọjọọ na ndị na-egbochi nchebe nwere ike ịba ụba ikpughe Rosuvastatin. A naghị atụ aro iji ngwakọta a Nje bu oria HIV nye ndị ọrịa.

    Njikọ Erythromycin na rosucard na-ebelata Aucnke ikpeazụ site na 20%, na ntinye uche kachasị - site na 30%.

    Mgbe ijikọ ọgwụ a Lopinavir na ritonavir na-abawanye nha anya ya Auc na ntinye uche kacha.

    Vitamin K Antagonists mgbe gị na rosucard na-emekọrịta ihe na-ebute mmụba mmekọrịta mba ụwa.

    Ezetimibe n'otu oge na rosuvastatin nwere ike ibute nsonaazụ ndị ọzọ.

    Antacid ogwu eji aluminom hydroxide ma ọ bụ magnesium na -ewelata ọgwụ ọgwụ n’anụ ahụ ihe dị ka ọkara. Yabụ n’etiti nnabata ha ka ị ga-ezumike ma ọ dịkarịa ala awa 2.

    Mgbe ị na-ejikọ Rosucard na ogwu mgbochi pụtara ileba anya n'ọnọdụ ndị ọrịa.

    Nyocha banyere Rosucard

    Nyocha banyere Rosucard na-akacha mma. Ngwaọrụ a na-adakarị ndị dọkịta ọdụ. Ọ bụ ezigbo ọnụ, yabụ ịzụta ya kwụ ọtọ. Ndị ejirila ọgwụ a alreadyụrụ ọgwụ ugbu a na-ahapụ nyocha banyere Rosucard, nke a na-akọ na ọgwụ ahụ nyeere ha aka ịnọgide na-enwe cholesterol nkịtị ma kwụsịkwa ọrịa ahụ.

    Ọnụ ego Rosucard

    A na-ewere ọnụahịa nke Rosucard dị oke ọnụ ma e jiri ya tụnyere ọtụtụ analogues. Ọnụ ego ọgwụ a na-akwụ na-adabere na ọdịnaya nke ihe ndị na-arụ ọrụ n'ime mbadamba ihe. Ya mere, ọnụahịa nke rosucard 10 mg na ngwugwu nwere efere 3 dị ihe dị ka 500 rubles na Russia ma ọ bụ 100 hryvnias na Ukraine. Na ọnụahịa nke Rosucard 20 mg na ngwugwu nwere efere 3 dị ihe dị ka 640 rubles na Russia ma ọ bụ hryvnias 150 na Ukraine.

    Ngwongwo ogwu

    Ihe na-arụ ọrụ na nkwadebe Rosucard, rosuvastatin, nwere akụrụngwa iji gbochie ọrụ mbelata, yana belata njikọ nke movalonate moleculerol, nke bụ maka ọrụ cholesterol n’ime mmalite nke mkpụrụ ndụ imeju.

    Ọgwụ a nwere mmetụta ọgwụgwọ na lipoproteins, na -ebelata njikọta ya site na mkpụrụ ndụ imeju, nke na-agbadata ọkwa nke lipoproteins dị ala dị ala ma na-eme ka mkpokọta lipoproteins dị elu nke belata.

    Pharmacokinetics nke ọgwụ Rosucard:

    • Oke kachasị nke ihe ndị mejupụtara n'ime ihe mejupụtara ọbara plasma, mgbe ewerechara mbadamba nkume ndị ahụ, na - apụta mgbe awa 5 gasịrị
    • Usoro ndu ogwu ahu bu 20.0%,
    • Igosi Rosucard na sistemụ dabere na ịbawanye oke onunu ogwu,
    • 90.0% nke ọgwụ Rosucard na-egbochi protein ndị dị na plasma, ọtụtụ mgbe, ọ bụ protein albumin,
    • Metabolism nke ọgwụ na mkpụrụ ndụ akwara na mbido mbụ bụ ihe dịka 10.0%,
    • Maka cytochrome isoenzyme Nke P450, rosuvastatin ndị ọrụ na-arụ ọrụ bụ mkpụrụ,
    • Ọgwụ 90.0% nwere ọgwụ dị n'ahụ, yana akụkụ akwara dị na ya,
    • 10.0 ka eji mkpụrụ ndụ akụrụ wepụta ya na mmamịrị,
    • Pharmlọ ọgwụ ọgwụ Rosucard adịghị adabere na ogo ndị ọrịa, yana okike. Ọgwụ ahụ na-arụ ọrụ otu, ma n'ahụ onye na-eto eto ma na ndị agadi, naanị n'oge agadi ka kwesiri ịnwe obere opekempe maka ọgwụgwọ nke kọlestrọl dị na ọbara.

    Mmetụta ọgwụgwọ mbụ nke ọgwụ Rosacard otu nke statins nwere ike inwe mmetụta mgbe ị takingụsịrị ọgwụ ahụ ruo ụbọchị 7. Mmetụta kachasị nke usoro ọgwụgwọ ga-ahụ mgbe ị afterụ ọgwụ ahụ maka ụbọchị 14.

    Costgwọ ọgwụ Rosucard na-adabere na ndị na-emepụta ọgwụ ahụ, mba a na-eme ọgwụ ahụ. Russian analogues nke ọgwụ dị ọnụ ala, mana mmetụta ọgwụ adịghị adabere na ọnụ ahịa ọgwụ ahụ.

    Ihe atụ nke Russian nke Rosucard, ka ọ na-ebelata ndepụta ntụpọ dị na cholesterol ọbara, yana ọgwụ ndị mba ọzọ.

    Ọnụahịa ọgwụ Rosucard na Russian Federation:

    • Ofgwọ nke rosucard 10.0 mg (mbadamba 30) - 550,00 rubles,
    • Rosucard 10.0 mg (90 pcs.) - 1540.00 rubles,
    • Ogwu izizi Rosucard 20.0 mg. (Taabụ 30.) - 860.00 rubles.

    Ndụ nchekwa na ojiji nke mbadamba Rosucard bụ otu afọ site na ụbọchị ewepụtara ha. Mgbe ụbọchị ahụ gwụsịrị, ọgwụ ka mma ịghara ị .ụ.

    Ọnụ ego Rosucard n'ụlọ ahịa ọgwụ dị na Moscow

    ọgwụ10 mg30 PC≈ 625 rub.
    10 mg60 pcs.≈ 1070 nkp.
    10 mg90 PC.≈ 1468 rub.
    20 mg30 PC≈ 918 rub.
    20 mg60 pcs.≈ 1570 nkp.
    20 mg90 PC.≈ 2194.5 rub.
    40 mg30 PC≈ 1125 rub.
    40 mg90 PC.≈ 2824 rub.


    Ndi dibia nyocha banyere rosacea

    Ikwu oke 3.3 / 5
    Irè
    Ahịa / mma
    Nsonaazụ

    Ezigbo analog sitere na Czech, nke emere site na akụrụngwa dị elu, gosipụtara ezigbo ezigbo ọgwụgwọ.

    Dịka iwu, a naghị anabata rosuvastatin maka ịnye ọnụahịa, na ikpe a abụghị iche, ọ dị mwute ikwu.

    Ọgwụ na-arụ ọrụ n’ezie, ọ na-emetụta ya naanị mgbe ọ kpọchara ọkachamara.

    Ikwu oke 3.8 / 5
    Irè
    Ahịa / mma
    Nsonaazụ

    O nwere ekele maka ịdị mma nke ọgwụ ọgwụ a - ọ na - eme ka metabolism nke Lipid dị mma site na obere nsogbu na usoro enweghị mgbakwunye, gbakwunye - nke a bụ n'ezie ọnụahịa, ma e jiri ya tụnyere obe.

    Enwere mmetụta dị n'akụkụ, mana a na-ahụkarị ya, n'ihi na m na-ede ya ugboro ugboro na obere mmebi - usoro nke opekata mpe 5-10 mg.

    Rating 2,5 / 5
    Irè
    Ahịa / mma
    Nsonaazụ

    Banyere ịnweta: statins abụghị ọgwụ dị ọnụ ala. Ma ha so n'ime ọgwụ ole na ole ahụ na-azọpụta ndụ n'ezie. N'ezie, ya na caveat - chebe ndụ nke ndị nwere ọrịa metụtara atherosclerosis - infarction myocardial, angina pectoris, atherosclerosis nke akwara akwara nke ala ala. Ọ bụrụ na statin na-akwụ 100-200 rubles, enwere m egwu ịde ya.

    Ọtụtụ mkpụrụ ndụ ihe omimi (ndepụtaghachi emepụtaghachi) nke akpụ akpụ, mana, n'ezie, ọ bụghị ha niile na-arụ ọrụ dokwara anya. Dọkịta nwere ọrụ ga - edenye naanị ụdị mkpụrụ ndụ ndị ahụ nke enwere data dị mma site na ọmụmụ gbasara ọgwụgwọ ọgwụgwọ na ọgwụ mbụ (n'ọnọdụ anyị, ọ bụ obe). Ndị na-ere ọgwụ n'ụlọ ọgwụ n'okwu ndị a, dịka iwu, anaghị agbadoro anya ma jụọ ha maka "dochie anya" ọ bụla, yana iji ntuziaka ha na "dochie anya", bụ ụzọ nke ga - eweta nkụda mmụọ na ọgwụgwọ.

    Nyocha nyocha nke ndị ọrịa Rosucard

    Amaghị m ihe ọ kpatara enweghị nsogbu ọ bụla maka ndị ikwu gị. Rosucard bụ ihe ịtụnanya. Mụ na di m ozugbo ị thisụsịrị ọgwụ a malitere afọ ọsịsa, obere oge ka nke ahụ gasịrị, ehighi ura na ihe ijuanya na obi ejikọtara. Ya mere, ugbu a anyị ga-ekpe dọkịta ka anyị mata ọdịnihu nnabata ya.

    Azụtara m Rosucard maka 508 rubles. Aụrụ m otu ọnwa mgbe otu ụbọchị gasịrị, kọlestrọl belatara site na 7 ruo 4.6. Anaghị m a drinkụ mmanya na mgbe ọnwa 2 ọzọ 6.8. Eguzogidere m ogologo oge, mana kpebiri: M ga-a .ụ. Anwale m ahịhịa dị iche iche, rankụọ ihe atherocliphite, enweghị mmetụta ọ bụla.

    "Ọnụ ego a ga - akwụ ụgwọ" - 900 re (!?) Nke a bụ ọnụ. Aghọtara m ebe a ị na-ahụ ebe a na-emeso ụfọdụ nde ndị nwere ego.

    Rosucard bụ ezigbo ọgwụ. Aghọtara m dọkịta m na nne nne m maka mgbochi. Ọgwụ gosipụtara nsonaazụ mgbe ihe dị ka ọnwa 1 iji. N'ọnọdụ anyị, ọ dị mkpa na ọgwụ ndị ọzọ nwere ike iburu rosucard. Ahụ bịara dị ya mma, ma kachasị mkpa, enweghị mmetụta ọ bụla. Anyị ahụghị ntụpọ ọ bụla.

    Nna nna m (72 afọ) nwere nsogbu obi afọ iri, ikekwe. N'ihe banyere nbibi ahụ, anyị gakwuuru dọkịta, onye dụrụ anyị ọdụ ka anyị bido rosacea. Ọnụahịa ahụ adịtụghị ọnụ, anyị na-a beenụ ya kemgbe ọnwa nke atọ. N'agbanyeghị, na onyinye nchịkwa onyinye onyinye cholesterol belatara nke ukwuu. Anyị nwere obi ụtọ na rosacea!

    Nkọwapụta dị mkpirikpi

    Rosucard (ihe eji arụ ọrụ - rosuvastatin) - ọgwụ na-ebelata ọgwụ n’otu n’otu. Taa, ihe dịka 80-95% nke ndị ọrịa na-arịa akwara obi (ọ bụrụ na anyị eburu mba ndị mepere emepe) na-ewere akpụ. Udiri ogwu ndi mmadu n’egwuregwu a n’egosiputa ntụkwasị obi zuru oke na ndi Cardiologists, nke ekwesiri itule kpam kpam: n’ahoso a, achoputara nsonaazu nke otutu ulo ogwu n’ulo ulo oru okachasi, na akwado nkwenye maka onwu onwuru onwonya mgbe a na acho ya. Na mgbakwunye, a gosipụtara nsonaazụ ndị ọzọ nke ọgwụ ndị a, nke zuru oke maka onwe ha: dịka ọmụmaatụ, mmetụta anti-ischemic. Mmetụta ọgwụ mgbochi nke statins na-ekwupụta nke na ụfọdụ ndị ọrụ ụlọ ọgwụ na-anwa ịgwọ ha ọrịa ogbu na nkwonkwo. Rosucard bụ ọgwụ eji eme ihe n'ụzọ zuru oke site na statin otu, nke akwadoro maka ojiji na mbido 2000 nke narị afọ gara aga. N'agbanyeghị asọmpi sitere na ihe oyiyi ise ndị ọzọ na ahịa ọgwụ taa, rosucard bụ otu kachasị (ma ọ bụrụ na ọ bụghị nke kachasi) ọgwụ ọjọọ na otu a dabere na uto uto nke ọnụọgụ ọgwụ. Mgbe ị aụsịrị otu ọgwụ otu ọgwụ, a na-ahụ ọnụ ọgụgụ kasị elu na plasma ahụ mgbe ihe dị ka awa ise gachara. Rosucard nwere ogologo ndụ kachasị ogologo nke awa iri na itoolu. Ngwongwo ọgwụ nke ọgwụ anaghị emetụta ihe dịka afọ, okike, ogo nke afọ afọ, ọnụnọ nke imeju (ma ewezuga n'ụdị ya siri ike). Mkpụrụ mosuiki rosuvastatin - ihe na - arụ ọrụ nke ọgwụ ahụ - bụ hydrophilic, na - ebute obere nsonaazụ ya na njikọta cholesterol n'ime akwara nke akwara nke akwara. N'ihi nke a, rosucard nwere obere mmetụta akpọzigharị na akụkụ ndị ọzọ. Uru ọzọ nke ọgwụ ahụ n’elu "ndị ibe" nọ na ngalaba ọgwụ (nke bụ isi atorvastatin na simvastatin) bụ na ọ naghị emeghachi omume na sistemụ cytochrome P450, nke na-enye ohere idegharị rosucard ọnụ na ọtụtụ ọgwụ ndị ọzọ (ọgwụ nje, antihistamines, ọgwụ antiulcer, ndị ọrụ antifungal, wdg.

    e.) n’enweghi nsogbu nke mmekorita ha na-achoghi. Achọla ịdị mma nke rosuvastatin (rosucard) ma a ka na-amụ ya n'ọtụtụ ule ụlọ ọgwụ. N'ime ọnụ ọgụgụ ọmụmụ dechara rue oge a, ọmụmụ MERCURY, nke gosipụtara uru dị ukwuu nke ọgwụ a karịa statins ndị ọzọ na nsonaazụ ya na profaịlụ egbugbere ọnụ, bụ ezigbo mmasị. Nzube cholesterol nke “jọrọ njọ” (LDL) mgbe ana - ewere rosucard na ndị ọrịa 86% (site na iji ọgwụ atorvastatin yiri nke ahụ nyere nsonaazụ achọrọ na naanị 80%). N'otu oge, ọkwa cholesterol (HDL) “dị mma” dị elu karịa mgbe ị na-eji atorvastatin. Mbelata mkpokọta nke ụmụ irighiri cholesterol atherogenic (nke bụ nke bụ isi nke LDL) abụghị naanị ebumnuche nke ọgwụgwọ Lipid. Okwesiri ime ka o mee ka ihe ndi ozo di nfe nke HDL lipoproteins, nke di ka iwu, belata. Na rosucard meriri nke a: na nsonaazụ ya na nhazi nke lipoproteins, ọ karịrị simvastatin na pravastatin. Ruo taa, a na-atụ aro ị toụ ọgwụ ahụ na ọgwụ 10-40 mg kwa ụbọchị.

    Nchekwa nke ọgwụgwọ abụghị akụkụ dị mkpa ya karịa nchekwa, ọkachasị ma ọ bụrụ na ezubere ọgwụ a maka ọtụtụ ndị ọrịa. Ejiri cerivastatin mee ka elebara anya banyere nsogbu nchekwa statin anya, nke wepụrụ ahịa ahụ n'ihi ọnụ ọgụgụ dị ukwuu nke nsonaazụ ya. N'akụkụ a, rosuvastatin (rosucard) ejirila nnwale nyocha siri ike n'ihe gbasara profaịlụ nchekwa ya. Na, dika ekwenyela n’oge ule ụlọ ọgwụ, ihe ọghọm nke mmetụta ndị ọzọ mgbe ị na-a theụ ọgwụ ahụ (n’okpuru usoro onunu ogwu a na-atụ aro ya) adịghị elu karịa nke ndị ọzọ eji eme ihe ugbu a.

    Ọgwụ Farmacology

    Hypolip Ebola ọgwụ site na otu nke statins. Nhọrọ asọmpi ahọpụtara nke HMG-CoA reductase, enzyme nke na - agbanwe HMG-CoA ka mevalonate, ihe na - amalite cholesterol (Ch).

    Na - eme ka ọnụ ọgụgụ ndị na - anabata LDL nọ na hepatocytes, nke na - eduga n'ịbawanye ụba na catabolism nke LDL, na - egbochi mkpokọta VLDL, na - ebelata mkpokọta LDL na VLDL. Belata mkpokọta nke LDL-C, HDL cholesterol-non-lipoproteins (HDL-abụghị-HDL), HDL-V, cholesterol zuru oke, TG, TG-VLDL, apolipoprotein B (ApoV), na-ebelata oke nke LDL-C / LDL-C, mkpokọta - HDL, Chs-abụghị HDL / Chs-HDL, ApoV / apolipoprotein A-1 (ApoA-1), na-eme ka mkpokọta Chs-HDL na ApoA-1 dịkwuo elu.

    Mpempe ume dị n’olu na-agbadata nha etu esi edere. Mmetụta ọgwụgwọ na-apụta n'ime izu 1 mgbe mmalite ọgwụgwọ, mgbe izu abụọ gachara 90% nke kachasị, rute oke site na izu anọ ma wee nọgide na-adịgide. Ọgwụ ahụ dị irè na ndị okenye nwere hypercholesterolemia nwere ma ọ bụ na-enweghị hypertriglyceridemia (n'agbanyeghị agbụrụ, okike ma ọ bụ afọ), gụnyere n'ime ndị ọrịa nwere ọrịa mellitus na hypercholesterolemia nke ezinụlọ. Na 80% nke ndị ọrịa nwere ụdị IIa na IIb hypercholesterolemia (nkewa Fredrickson) na ntinye izizi nke LDL-C nke ihe dịka 4.8 mmol / L, ebe ị na-a theụ ọgwụ ahụ na ọgwụ nke 10 mg, ịta LDL-C erughị 3 mmol / L. N'ime ndị ọrịa nwere hypercholesterolemia homozygous familialia na-anata ọgwụ ahụ na ntụtụ 20 mg na 40 mg, mbelata nkezi na mkpokọta LDL-C bụ 22%.

    A na-ahụta mgbakwunye mmetụta na ngwakọta na fenofibrate (n'ihe metụtara mbelata mkpokọ TG yana nicotinic acid na doses na-egbusi ike (erughị 1 g / ụbọchị) (n'ihe metụtara mbelata mkpokọ nke HDL-C).

    Etu esi ewere rosucard?

    Ekwesịrị iji ọnụ mmiri zuru ezu were Rosucard ọgwụ ahụ. Amachibidoro ị aụ mkpụrụ osisi mbadamba ụrọ, n'ihi na ọ bụ akpụkpọ anụ nke na-agbaze n'ime eriri afọ ya.

    Tupu ịmalite usoro ọgwụgwọ ahụ na ọgwụ Rosucard, onye ọrịa ahụ kwesịrị ịrapara na nri anticholesterol, nri ahụ ga-esonyekwa usoro ọgwụgwọ niile na akpụ akpụ, dabere na njiri arụ ọrụ - rosuvastatin.

    Dọkịta na-ahọrọ usoro ọgwụgwọ maka onye ọrịa ọ bụla, dabere na nsonaazụ nyocha nke ụlọ nyocha, yana na ntinye onwe onye nke ahụ onye ọrịa.

    Naanị dọkịta, ọ bụrụ na ọ dị mkpa, maara otu esi edochi mbadamba Rosucard. Ndozi dose na iji ọgwụ ọzọ dochie ọgwụ ahụ emeghị tupu izu abụọ site na mgbe nchịkwa.

    Usoro ọgwụgwọ nke Rosucard nke mbụ ga-ebuli ihe karịrị milligram 10.0 (otu mbadamba) otu ugboro kwa ụbọchị.

    Nke nta nke nta, mgbe a na-agwọ ya, ọ bụrụ na ọ dị mkpa, n’ime ụbọchị iri atọ, dọkịta kpebiri ikpelata ị doụ ya.

    Iji bulie ubochi nke ọgwụ Rosucard kwa ụbọchị, achọrọ ihe ndị a:

    • Ofdị hypercholesterolemia siri ike, nke chọrọ oke onunu ogwu nke 40.0 milligram.
    • Ọ bụrụ na na usoro onunu ogwu nke 10.0 milligrams, lipogram gosipụtara mbelata nke cholesterol. Dọkịta na-agbakwụnye usoro onunu ogwu nke 20.0, ma ọ bụ ozugbo ọgwụ kachasị,
    • Na nsogbu ndị siri ike nke nkụda obi.
    • N'iburu ọkwa nke ọrịa, atherosclerosis.

    Patientsfọdụ ndị ọrịa, tupu ịbawanye usoro onunu ogwu, chọrọ ọnọdụ pụrụ iche:

    • Ọ bụrụ na ndị na-egosi akụrụ mkpụrụ ndụ akwara kwekọrọ na ọnụ ọgụgụ ụmụaka-Pugh nke 7.0 isi, agaghị atụ aro ịba ụba nke Rosucard,
    • N'ihe banyere ọdịda akụrụ, ị nwere ike iji mbadamba ọgwụ 0,5 malite ọgwụ ahụ kwa ụbọchị, ma emesịa ị nwere ike jiri nwayọ dịkwuo milligram 20,0, ma ọ bụ ọbụna ruo n'ọ̀tụ̀tụ̀ kasịnụ.
    • Na oke akụrụ akụkụ ọdịda, anaghị anabata statins,
    • Ogo ogo oke oke akụkụ akụrụ. Ọ bụ ndị dọkịta ekwenyeghi ka ọnụọgụ Rosucard ọgwụ ịchọrọ ị ,ụ ya,
    • Ọ bụrụ na enwere ihe ọghọm nke ọrịa, myopathy kwesịkwara ịmalite site na mbadamba ụrọ 0,5 na mgbochi nke 40.0 milligrams amachibidoro.
    Dose ukpụhọde ke ini ọgwụgwọn’ime ọdịnaya ↑

    Mmechi

    Enwere ike iji ọgwụ Rosucard mee ihe na ọgwụgwọ nke cholesterol dị n'ọbara, naanị yana mgbakwunye nri nri anticholesterol.

    Ọ bụrụ na imee ihe oriri riri gị oge, ọ ga - egbu oge ọ na - agwọ ọrịa ma mee ka mmetụta ọjọọ nke ọgwụ ahụ dị njọ n'ahụ ahụ.

    Enweghị ike iji ọgwụ Rosucard mee ihe dị ka ọgwụ ịchọrọ onwe ya, mgbe ị na-edekwa ya, amachibidoro ịhazie usoro ịche mbadamba, yana ịgbanwe usoro ọgwụgwọ.

    Yuri, 50 afọ, Kaliningrad: statins belata cholesterol m n’izu atọ. Ma mgbe nke ahụ gasịrị, usoro ntụgharị ahụ bilitere ọzọ, aghaghịkwa m iji usoro ọgwụgwọ statin ọzọ.

    Naanị mgbe dọkịta gbanwere ọgwụ m gara aga ka ọ bụrụ Rosucard, achọpụtara m na ọgwụ ndị a enweghị ike iweghachi cholesterol m na nkịtị, kamakwa ịbawanye ya nke ọma mgbe usoro ọgwụgwọ gasịrị.

    Natalia, 57 afọ, Ekaterinburg: cholesterol malitere itolite n’oge menopause, nri ahụ enweghị ike belata ya. Anọwo m na-a roụ ọgwụ rosuvastatin ruo afọ 2. Ọnwa atọ gara aga, dọkịta dochiri mbadamba ọgwụ Rosucard m gara aga.

    Enwere m mmetụta nsonaazụ ya ozugbo - ahụ dị m mma ma ọ tụrụ m n'anya na enwere m ike kilo kilogram 4 karịa.

    Nesterenko N.A., kadiologist, Novosibirsk - Ana m edepụta statins maka ndị ọrịa naanị naanị mgbe ejirila ụzọ dị ala nke cholesterol na enwere nnukwu ihe ize ndụ nke ịmalite ọrịa cardio, yana atherosclerosis.

    Statins nwere ọtụtụ mmetụta adịghị mma n'ahụ, na-emetụta ogo ndụ ndị ọrịa.

    Mana iji ọgwụ Rosucard mee ihe m mere, achọpụtara m na ndị ọrịa kwụsịrị mkpesa banyere mmetụta ọjọọ nke statins. Ndokwa na ntuziaka niile maka ojiji ga-enye onye ọrịa obere mmeghachi omume anụ ahụ.

    Ahapụ Gị Ikwu

    https://pobedidijabetes.org

    pobedidijabetes.org © Copyright 2024. All Rights Reserved. | Imeri Ọrịa shuga!