Etu esi eji Accupro? > Ọgwụgwọ na mgbochi

Quinapril hydrochloride (INN - Quinaprilum) bụ ethyl ester nke ACE inhibitor quinaprilat nke na-enweghị ìgwè sulfide. Mgbe ị na-a theụ ọgwụ ahụ n'ime, a na - ewepụ ngwa ngwa quinapril na quinaprilat (quinapril diacid, bụ isi metabolite), nke bụ ihe mgbochi ACE dị irè. Usoro nke quinapril bụ ihe mgbochi nke ịghagharị n'ọbara na ACE anụ ahụ, nke na-ebelata ọrụ vasopressor na secretion nke aldosterone. Mbelata ogo angiotensin II site na usoro nzaghachi na-eduga n'ịba ụba nke renin na ọrụ ya na plasma ọbara. Agbanyeghị na ekwenyere na isi usoro nke antihypertensive na-egosipụta site na sistemụ renin-angiotensin-aldosterone, quinapril gosipụtara mmetụta antihypertensive ọbụna na ndị ọrịa nwere ọbara mgbali ala ala (ọbara mgbali akwara).
Nchịkwa nke quinapril ka ndị ọrịa, malite na obere ọbara mgbali elu (nnukwu ọbara ọgbụgba) na ọnụọgụ 1040 mg, na-eduga na mbelata ọbara mgbali ma n'oche na ọkwá, yana obere mmetụta na ụda obi. Mmetụta antihypertensive na-etolite n'ime otu elekere 1, nsonaazụ kasịnụ - awa 2-4 mgbe ị takingụ ọgwụ ahụ. N'ime ụfọdụ ndị ọrịa, a na-achọpụta mmetụta kwụsiri ike mgbe izu 2 gachara. Mgbe ejiri ọgwụ ndị a tụrụ aro ya, a na-enwe mmetụta antihypertensive nke ọgwụ n'ọtụtụ ndị ọrịa ruo awa 24 ma na-adịgide iji ọgwụ ogologo oge. Mbelata ọbara mgbali mere site na quinapril sochiri mbelata obi na nguzogide arịa nile nke akụrụ ya na obere mgbanwe ma ọ bụ enweghị mgbanwe mgbanwe mkpụrụ-obi, usoro gbasara obi, yana ọbara gbasara akụrụ, ọnụego mkpo na mkpo.
Mgbe nchịkwa ọnụ gachara, a na-enweta mkpo kachasị nke quinapril na plasma ọbara n'ime awa 1. Ihe dị ka 60% nke ọgwụ ahụ na-abanye, na usoro bioavailability dị n'ụdị quinaprilat bụ 38%. Oke ruru quinaprilat na plasma erutela ihe dịka awa 2 mgbe etinyere quinapril. Ndụ ọkara nke plasma dị ihe dị ka awa 1. Quinaprilat bụ nke kachasị site na mpụta ezumike, ma nwee ọkara ndụ nke uru dị (ihe dịka awa 3). Ihe dị ka 97% nke quinapril ma ọ bụ quinaprilat na-ekesa na plasma na-ejikọ na protein. N'ime ndị ọrịa nwere ọdịda akụrụngwa, ọkara ndụ nke quinaprilat na-abawanye site na mbelata mmebi nke creatinine. Ọmụmụ ọgwụ Pharmacokinetic dị na ndị ọrịa nwere nnukwu akụrụ oke akwara na-anọdụ ala na -akwụ ala ma ọ bụ usoro ọmụmụ ihe na-aga n'ihu na-egosi na usoro ọgwụgwọ adịghị emetụta nkpochapu nke quinapril na quinaprilat. E nwere njikọ dị n'etiti mkpochapụ nke ewepụsị ihe site na plasma ọbara na mkpocha nke creatinine. A na-ebelatakwa Quinaprilat na ndị ọrịa agadi (karịa 65). Ọkpụkpụ nke quinaprilat belata na ndị ọrịa nwere ọrịa imeju na-egbu egbu n'ihi nbibi nke quinapril. Quinapril na metabolites ya abanyeghị na BBB.

Ojiji Akkupro ji ọgwụ eme ihe

Nnukwu ọbara na arịa (AH)
Monotherapy: Thezọ ịhọrọ Accupro na-atụ aro ka ọ dị maka ndị ọrịa na-a takeaghị ọgwụ mgbarụ bụ 10-20 mg otu ugboro n'ụbọchị. Dabere na nsonaazụ a na-adakarị, enwere ike ịbawanye dose ahụ gaa na 20-40 mg / ụbọchị na 1-2 doses. Ọ bụrụ na ọ dị mkpa, enwere ike ịme ndozi dose na etiti oge nke izu 2-4.Mmetụta dị mma nke ọbara mgbali n'ọtụtụ ndị ọrịa na-enweta mgbe ị na-a theụ ọgwụ 1 oge kwa ụbọchị. Ogo kachasị nke quinapril bụ 80 mg / ụbọchị.

N’otu oge, nchịkwa diuretics: n’ebe ndị ọrịa kwesịrị ịga n’ihu gwọọ ọrịa, ọgwụ a na-atụ aro mbụ nke Accupro bụ 5 mg, emesia enwere ike ịbawanye ya nwayọ iji nweta nsonaazụ kachasị mma.

Ọkpụkpụ Obi Obi
Usoro akwadoro ịmalite bụ 5 mg na 1-2 doses. Ọ bụrụ na anabataghị ọgwụ mbụ nke quinapril, enwere ike ịbawanye ya ka ọ bụrụ uru dị, ana -adakarị 1040 mg / ụbọchị na usoro abụọ kewara.
Mwepu quinapril dabere na akụrụ arụ arụ. Nkwanye ọgwụ mbụ nke Accupro na ndị ọrịa nwere nhichapụ ihe dị ka 30 ml / min bụ 5 mg, na ndị ọrịa nwere nhichapụ ihe na-erughị 30 ml / min - 2.5 mg. Ọ bụrụ na anabatasiri ọgwụ izizi ahụ nke ọma, enwere ike ị takenụ ọgwụ ahụ ugboro 2 n'ụbọchị site na ụbọchị na-esote N'ihi enweghị hypotension dị ukwuu ma ọ bụ njọ dị ukwuu na ọrụ gbasara akụrụngwa, enwere ike ịbawanye dose ahụ site na obere oge izu 1, na-eburu n'uche ọgwụgwọ na akụrụngwa hemodynamic.

Ihe mgbochi iji ọgwụ Akkupro

Hypersensitivity na quinapril ma ọ bụ ihe ndị ọzọ nke ọgwụ ahụ, ọnụnọ nke akụkọ banyere ọrịa angioedema jikọtara ya na ọgwụgwọ ACE inhibitor gara aga, ime na lactation, na nwata.
Enyochala echiche nke ịgafe ndị ọzọ na - egbochi ACE.

Nsonaazụ nke ọgwụ Akkupro

A na-akpọkarị ya obere oge. Ọrịa ndị a na-ahụkarị na ọnwụnwa a na-achịkwa bụ: isi ọwụwa (7.2%), dizzness (5.5%), ụkwara (3.9%), ike ọgwụgwụ (3.5%), rhinitis (3.2%) ), ọgbụgbọ na / ma ọ bụ vomiting (2.8%), myalgia (2.2%). Okwesiri iburu n'uche na ụkwara anaghị akwụsi ike ma na-apụ n'anya mgbe ọ kwụsịrị ọgwụgwọ.
Mmeghachi omume ojoo na-adabakarị ọrịa, enwere ike ma ọ bụ nwee ihe jikọrọ ma ọ bụ jikọtara ya na ọgwụgwọ quinapril (na ma ọ bụ na-enweghị conurek ọrịa diuretic) na ọmụmụ na-achịkwa ma na-achịkwa ya na oge ole na-achọpụta na ọmụmụ ụlọ ọgwụ ma ọ bụ mgbe nyocha ndebanye * gụnyere.

Ọrịa Hematopoietic na lymphatic: hemolytic anaemia *, thrombocytopenia *.
Si dịghịzi usoro: mmeghachi omume anaphylactoid *.
Site n'akụkụ nke usoro ụjọ ahụ:, vertigo, ụjọ, ịda mba, ụra.
Site n'akụkụ akụkụ ahụ nke ọhụụ: amblyopia.
Si usoro obi: angina pectoris, palpitations, tachycardia, hypotension postorial *, syncope *, vasodilation.
Site na nri digestive: ọnụ ma ọ bụ akpịrị, akpọnwụ akpịrị, panreatitis *.
Na akpukpo ahu: alopecia *, exfoliative dermatitis *, itching, ịsụsọ excessiveụbiga nke ukwuu, pemphigus *, mmeghachi omume nke mkpụrụ ndụ *, ọnya anụ ahụ.
Site na usoro mọzụlụ:arthralgia
Site na usoro mkpụrụ ndụ: ọnya ọnya na-efe efe, enweghi ume.
Ọrịa niile na mbepụ na saịtị ịgba ahụ: edema (mpaghara na oke ya),
Otu ihe ojoo: anabataghi angioedema na 0.1% nke ndị ọrịa na-eji quinapril. Mgbe ụfọdụ, dịka ndị ọzọ na - egbochi ACE, eosinophilic pneumonitis * na ịba ọcha n'anya na-ahụ quinapril.
Nsonaazụ nnwale ụlọ nyocha: adịkarịghị - agranulocytosis na neutropenia (mmekọrịta causal ha na ojiji nke quinapril bụ nke a na-apụghị ịtụkwasị obi), hyperkalemia.
Creatinine na ọbara urea nitrogen. A hụrụ mmụba (ihe karịrị 1.25 karịa elu karịa nke nkịtị) nke serin creatinine na urea nitrogen na 2 na 2% nke ikpe, n'otu n'otu, yana ọgwụgwọ quinapril.Mmụba dị ka ndị ọrịa na-anata ọgwụ yana yana diuretics karịa ndị na-anata monotherapy quinapril.
Ọkpụkpụ Angioneurotic. A kọrọ banyere mmepe nke angioedema na ndị ọrịa natara ndị na - egbochi ACE (gụnyere 0.1% nke ndị ọrịa na - anata quinapril). Ọ bụrụ na onye ọrịa ahụ amalitere angioedema nke ogwooro, ihu, ire, quinapril kwesịrị ịkwụsị ozugbo, onye ọrịa ahụ ga-anata ọgwụgwọ zuru oke ma lelee ruo mgbe edem na-apụ kpamkpam. Ọ bụrụ na edema na-apụta naanị ihu na egbugbere ọnụ, achọghị ọgwụgwọ a kapịrị ọnụ n'ọtụtụ ọnọdụ, ọ ga-adị mma ka ị jiri ọgwụ mgbochi hichaa ihe mgbaàmà ahụ. Angioedema nke ire, larynx na glottis nwere ike itinye ndụ n'ihe egwu. Site na mmepe ya, ekwesịrị inye ọgwụ ngwa ngwa kwesịrị ekwesị ozugbo, nke na-agụnyekarị nchịkwa sc nke 0.3-0.5 ml nke epinephrine (epinephrine) (1: 1000). Ndị ọrịa nwere akụkọ ọdịnala nke enweghị mmekọ na ọgwụ inhibitor ACE nwekwara ohere dị ukwuu maka angioedema n'oge ọgwụgwọ ya na onye na - egbochi ACE.
N'ime ndị ọrịa nke agbụrụ Neroid, nke eji ya ACE inhibitors, okwu banyere mmepe nke angioedema juru ebe niile karịa ndị ọrịa nke agbụrụ ndị ọzọ. Ndị ọrịa nke agbụrụ Negroid chọpụtakwara mmetụta ntakịrị ihe nke ndị na - egbochi ACE na ọbara mgbali elu ma e jiri ya tụnyere agbụrụ ndị ọzọ.
Nnukwu angioedema. N'ime ndị ọrịa na-eji ọgwụ mgbochi ACE, a hụrụ ngosipụta nke angioedema afọ. Ndị ọrịa dị otú a mere mkpesa nke mgbu afọ (ya na / na-enweghị ọgbụgbọ ma ọ bụ ọgbụgbọ), n'ọnọdụ ụfọdụ enweghị akara na akụkọ banyere mmepe nke angioedema nke ihu na ọkwa C-1 esterase kpebiri. A malitere nyocha nke ọrịa angioedema site na iji trọgramo akụkụ ahụ dị n'ime ma ọ bụ ultrasound ma ọ bụ n'oge ịwa ahụ. Ngosiputa ndia ghapuru mgbe akwusila ogwu ya. Ekwesịrị itinye mgbakwunye angioedema na nchọpụta ọdịiche dị na ndị ọrịa nwere mgbu afọ na-anakwere ọgwụgwọ ACE inhibitor. Ọrịa nwere ọrịa angioedema nke anaghị ejikọ ya na ọgwụgwọ ACE inhibitor therapy nwere ike ịnwekwu ohere angioedema n'oge ọgwụgwọ ya na onye na - egbochi ACE.
Mmeghachi omume anaphylactoid.
Ọpụpụ. N'ime ndị ọrịa na-anata ndị na-egbochi ACE n'oge mkpasu iwe maka hymenoptera venom, a hụrụ mmeghachi omume anaphylactoid na-eyi ndụ egwu. N'ime ụfọdụ ndị ọrịa, mmeghachi omume ndị a emeghị oge nkwụsịtụ nwa oge na nchịkwa nke ndị na - egbochi ACE, mana ha na-amaliteghachi na ihe omume iwe iwe iwe.
Apheresis nke nwere obere lipoproteins dị ala. N'ime ndị ọrịa were nnabata LDL na mmiri nnwale, a na-ahụ mmeghachi omume anaphylactoid na ọgwụgwọ concomitant na ACE inhibitor.
Ahụ ikeIhe omuma nyocha nke ulo ogwu gosiputara na ndi oria na –ele onodu akwara di ala site n’iji otutu membranes nke nwere oke igba (polyacrylonitrile membranes) nwere ike ịmalite mmeghachi omume anaphylactoid ka ha na - eji ihe mgbochi ACE. E kwesịrị izere ụdị njikọ a mgbe ị na-eji ọgwụ mgbochi ọzọ ma ọ bụ membranes ọzọ maka ịba ọcha n'anya.
Nnukwu ọgbụgba. N'ime ndị ọrịa nwere ọbara mgbali elu na-enweghị mgbatị ahụ (mgbali ọgbụgba akwara) nke a na-agwọ Acupro, hypotension adịkarịghị etolite, mana ọ nwere ike ịbụ nsonaazụ nke ọgwụgwọ na ndị na-egbochi ACE na ndị ọrịa nwere nrụgide mmiri-electrolyte n'ihi nsogbu akwara, nri nwere obere nnu, yana mgbanye.
N'ime ndị ọrịa nwere ọrịa obi ọgbụgba, nke ihe ọghọm nke ịrịa ọrịa hypotension dị oke ukwuu, a ga-amalite ọgwụgwọ na quinapril na usoro a tụrụ aro n'okpuru nlekọta ahụike, a ga-enyocha ndị ọrịa a izu abụọ mbụ nke ọgwụgwọ yana oge ọ bụla ịba ụba nke quinapril.
Site na mmepe nke hypotension symptomatic, a ga-atunye onye ọrịa ahụ azụ ma, ọ bụrụ na ọ dị mkpa, mepụta iv infusion nke isotonic sodium chloride solution. Oge mmeghachi azụ hypotensive abụghị ihe mgbochi maka ị useụ ọgwụ ọzọ, agbanyeghị, na mmepe nke mmeghachi omume dị otú ahụ, a ga-atụle nke iji obere ọgwụ ahụ ma ọ bụ nkwụsị nke ihe mmerụ ahụ.
Ndị ọrịa natara ọgwụgwọ diuretic na mmalite nke ọgwụgwọ quinapril nwere ike ịmalite hypotension Symptomatic. Ọ bụ ihe amamihe dị na ịkagbu diuretic ụbọchị 2-3 tupu ịmalite ọgwụgwọ na quinapril. Ọ bụrụ na ọbara na-ejighị ọgwụ monina na-achịkwa quinapril, a ga-amaliteghachi ihe mkpịsị ụkwụ. Ọ bụrụ na ọ gaghị ekwe omume ịjụ ọgwụ mgbatị ahụ, ojiji nke Acupro kwesịrị ịmalite site na obere usoro mmalite.
Neutropenia na agranulocytosis. Mgbe ụfọdụ enwere ike ịnabata ndị na - egbochi ACE na nkụda mmụọ na nkụda mmụọ nke ndị ọrịa nwere ọbara mgbali elu na - enweghị mgbagha (ma ọ bụ na - arịa ọbara mgbali), mana ọ na - abụkarị, dịka iwu, na ndị ọrịa nwere akụrụngwa akwara, yana yana collagenoses. Mgbe ị na-eji ndị na - egbochi ACE na ndị ọrịa nwere collagenoses na / ma ọ bụ ọdịda akụrụngwa, nlebara anya nke ọnụ ọgụgụ leukocytes dị mkpa.
Ughkwụ ụgbụ. Ndị ọrịa na-eji ihe mgbochi ACE, gụnyere quinapril, nwee ụkwara mgbe ụfọdụ. Abụkarị ụkwara adịghị amịpụtaghị mkpụrụ, na-adịgide, ma na-apụ n'anya mgbe akwụsịrị ọgwụgwọ. Ekwesịrị ịtụle ụkwara nke ejiri ACE inhibitors n'ime nchọpụta ọdịiche nke ụkwara.

DoD akpa Dope (mg) tụrụ aro ya.

O nweghi ahụmịhe rue oge iji nye ohere ikwu maka ịchọrọ ndị ọrịa a.

N'ime ndị nwere hyperensitivity n'ihi mgbochi nke ọrụ nke renin - angiotensin - aldosterone sistemụ, arụ ọrụ ezughi oke ọrụ enwere ike. N'ime ndị ọrịa nwere nnukwu obi ike, nke ọrụ akụrụ na-adabere na ọrụ nke renin - angiotensin - usoro aldosterone, ọgwụgwọ na ndị na-egbochi ACE, gụnyere quinapril, nwere ike iduga mmepe nke oliguria na / ma ọ bụ azotemia na-enwe ọganihu, na adịghị adị, nnukwu akwara gbasara akwara, gụnyere ọnwụ.
Oge mgbatị nke quinaprilat abawanyele n'ihi mbelata nke ikike iwepụta nke creatinine. N'ime ndị ọrịa nwere nhichapụ mkpụrụ osisi ≤60 ml / min, ekwesịrị ịkọwa quinapril na obere ala (lee APPLICATION). Should beụ ọgwụ a na-enye ndị ọrịa dị otú ahụ, a ga-ahazi site na ala ruo na nke dị elu, na-eburu n'uche ọgwụgwọ ahụ, yana na-enyochakwa akụrụngwa mgbe niile (ọ bụ ezie na ọmụmụ mbụ egosighi ekpughe njọ ya mgbe ị na-eji quinapril).
N’ebe ụfọdụ ndị ọrịa nwere ọbara mgbali elu (ọbara mgbali akwara) ma ọ bụ nkụda obi na-enweghị ihe ịrịba ama doro anya nke mmebi akwara gbasara akụrụ n’oge ọgwụgwọ na quinapril, ọkachasị ya na diuretic, enwere ịrị elu na ọkwa urea nitrogen na serum creatinine. Mmụba a na - agbanwegharị obere oge na mwepu nke ACE inhibitor na / ma ọ bụ diuretic. Ihe ọghọm nke ụdị mgbanwe ndị a dị elu na ndị ọrịa nwere ọrụ ezumike na-arụ ọrụ. N'ụdị ndị ahụ, mbelata belata na ịwepu ọgịga na / ma ọ bụ quinapril nwere ike ịdị mkpa.
Na omumu ihe omumu nke ndi oria ha na obara obara (ọbara mgbali akwara) ya na akwara ma obu ha na akuko, site na onye ogwu ACE, a gha abawanye na urea nitrogen and serum creatinine. Mmụba a na-agbanwegharị oge niile mgbe etinyere ọgwụ na ACE inhibitor na / ma ọ bụ diuretic.N'ọnọdụ ndị dị otú a, ọ dị mkpa iji nyochaa ọrụ akụrụ nke ndị ọrịa n'oge izu ole na ole mbụ nke ọgwụgwọ.
Ọrụ imeju na-arụ ọrụ. Ekwesịrị iji Quinapril na ọnya mee ya na nlezianya na ndị ọrịa nwere ọrụ nkwarụ ma ọ bụ ọrịa imeju na-aga n'ihu, ebe ọ bụ na obere mgbanwe na mmiri-electrolyte nguzozi nwere ike ibute mmepe nke hepatic coma. Metabolic quinapril na quinaprilat na-adịkarị n'okpuru nduzi nke hepatic esterase. Ọkpụkpụ nke quinaprilat belata na ndị ọrịa nwere ọrịa imeju na-egbu egbu n'ihi mmebi nke mkpochapụ nke quinapril.
Hyperkalemia na potassium-sparing diuretics. Abụọ n'iji ihe ndị ọzọ ACE inhibitors mee ihe, yana iji ojiji nke quinapril, ọkwa nke ion potassium dị n'ọbara nwere ike ịba ụba. Iji otu oge iji quinapril nwere ike belata hypokalemia nke thiazide diuretics kpatara. Emebeghị nnyocha maka ojiji nchịkọta quinapril na potassium na-enye ya ọgwụ. Ebe enwere ihe ọghọm nke mmụba na mkpo ọka potassium, ọ dị mkpa na ịmalite ọgwụgwọ ọgwụgwọ na ndị ọrịa na-enweta ọgwụ ọgwụgwọ na-enye ọnụnọ potassium na-akpachara anya na-elebanye anya na ọkwa potassium.
Hypoglycemia na ọrịa shuga. Ojiji nke ACE inhibitors nwere ike isonyere hypoglycemia na ndị ọrịa nwere ọrịa shuga na-a insụ ọgwụ insulin ma ọ bụ ọnụ nke hypoglycemic. Ya mere, ọ dị mkpa iji nlezianya nyochaa ọnọdụ nke ndị ọrịa dị otú ahụ.
Gerywa Ahụ / Anesthesiology. Ọ bụrụ n'ịwa ahụ dị mkpa, ekwesịrị ịgwa onye na - ahụ maka ọgwụ na - agwọ ọrịa na onye ọrịa na - ewere quinapril, ebe ọ bụ na mmepe nke nnukwu akwara ọbara / ọdịda ga - ekwe omume.
Jiri na ndị agadi. Afọ anaghị emetụ mmetụta dị mma yana profaịlụ nchekwa nke ọgwụ, yabụ, usoro ọgwụgwọ mbụ a tụrụ aro Acupro na ndị ọrịa agadi dị 10 mg otu ugboro n’ụbọchị, ọ bụrụ na ọ dị mkpa, enwere ike idozi ya n’iburu n’ichekwa ọkwa ọbara mgbali elu.
Jiri n'oge ime na lactation
Mgbe ejiri ya n’oge afọ ime, ndị na - egbochi ACE nwere ike ibute ọrịa nwa ebu n’afọ na ụmụ ọhụrụ. Tupu iji quinapril n’oge ime, ịkwesịrị ịtụle mmetụta uto ọ nwere ike ịmetụta nwa ebu n’afọ. Ọ bụrụ na ime mere mgbe ị na-ewere quinapril, a ga-akwụsị ọgwụ a.
Mgbe ị na-ewere ACE inhibitors n'oge ọmụmụ nke II na III nke afọ ime, enwere akụkọ banyere hypotension, oke gbasara akụrụ, hypoplasia isi na / ma ọ bụ ọnwụ nke ụmụ amụrụ ọhụrụ. A kọkwara mmepe nke oligohydroamnion, nke nwere ike bụrụ nsonaazụ nke mbelata nke ọrụ nwa ebu n'afọ, na njikọ aka nke aka akpụ ụkwụ, nrụrụ nke akwara, hypoplasia ngụgụ na azụmazụ nke intrauterine. Ọ bụrụ na n’oge ọgwụ nke mkpụrụ atọ ma ọ bụ nwa ebu n’afọ nwere ọgwụ ahụ, ekwesịrị ịgwa nne ahụ ozugbo o kwere omume n ’ọrịrị, ọ bụrụgodi na-achọpụta na ihe ọghọm ndị ahụ.
Shouldmụ nwanyị ndị jiri ihe mgbochi ACE n’oge ọnwa nke abụọ na nke III ka a ga-eme ka ha mata ihe nwere ike ibute nwa ebu n’afọ; ịlele ultrasound ugboro ugboro dị mkpa iji chọpụta oligohydroamnion. N'ihe banyere nchọpụta nke oligohydroamnion, a ga-akwụsị iji ojiji nke quinapril, enwere ike ịgbatị ya naanị ma ọ bụrụ na ọ dị mkpa maka nne.
Ihe ọzọ nwere ike ibute nwa ebu n’afọ na nwa amụrụ ọhụrụ mgbe ị na-eji ndị na - egbochi ACE bụ ndọtị azụ intrauterine, akaghi aka na mmechi nke ductus arteriosus, yana ọnwụ nwa ebu n’afọ nwekwara ike ime. Agbanyeghị, a ka amabeghị ihe na-akpata mmepe nke ụdị mmetụta ndị a - iji ọgwụ ahụ ma ọ bụ ọrịa na-efe efe nke nne.Amabeghị ihe na-akpata nsogbu na onwa mbu nke ime nwere ike ibute mmebi nwa ebu n'afọ.
Infmụaka ndị nne ha nwetara ACE inhibitor n'oge afọ ime, yabụ na ekpughere ụmụaka n'ime intrauterine mmetụta nke ndị na - egbochi ACE, chọrọ nlele anya - njikwa hypotension, oligouriia na hyperkalemia. Ọ bụrụ na oliguria emee, a ga-elebara ya anya maka ịmịnye ọbara mgbali na otite nke akụrụ.
Apụrụ ndị na - egbochi ACE, gụnyere quinapril, na mmiri ara ara. Ya mere, n'oge ọgwụgwọ Acupro, a na-atụ aro ịkwụsị inye ara.
Childrenmụaka. Emebeghị nyocha na nchekwa nke Accupro na ndị ọrịa ụmụaka.
Ikike ime ka mmetuta mmeghachi omume na-anya mgbe ị na-anya ụgbọ ma na-arụ ọrụ nwere ike ihe egwu: Ọsọ ọsọ nke mmeghachi omume mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ọrụ na usoro ndị ọzọ na mmalite nke ọgwụgwọ na Accupro nwere ike ịnwe.

Mmekorita nke ọgwụ Akkupro

T were tetracycline na quinapril na-ebelata nnabata tetracycline n'ihe dị ka 28-37%. Mbelata mmịpụta ahụ bụ n'ihi ọnụnọ magnesium carbonate dị ka onye na-enyocha ọgwụ Akkupro.
Ndị ọrịa na-a litụ ọgwụ lithium na ndị na-egbochi ACE n'otu oge gosipụtara ọkwa dị elu nke mmiri lithium na ihe mgbaàmà nke egbu egbu lithium. Ekwesịrị ịgwakọta ọgwụ ndị a ka akpachara anya; Additional Theụkwu ọgwụ eji eme ihe na-abawanye ohere ịxụ mmanya nke lithium.
Mgbe etinyere quinapril na ogwu nke propranolol, hydrochlorothiazide, digoxin ma ọ bụ cimetidine, ọ nweghị mmekọrịta dị n'etiti ụlọ ọgwụ na-achọpụta ọgwụ. Mmetụta anticoagulant nwere otu ọgwụ warfarin (na usoro prothrombin) adịghị agbanwe nke ukwuu ka ị na-ewere quinapril ugboro abụọ kwa ụbọchị.
Oge ọgwụgwọ na thiazide diuretics na / ma ọ bụ β-adrenergic blockers na-akwalite mmetụta antihypertensive nke quinapril.
Site na nhazi oge nke quinapril na potassium-sparing diuretics (spironolactone, triamteren ma ọ bụ amiloride), mgbakwunye potassium ma ọ bụ ndị nwere nnu nnu nwere mmanụ, ekwesịrị iji ya kpachara anya ma nwee njikwa kwesịrị ekwesị na ọkwa nke potassium na ọbara ọbara. N'ime ndị ọrịa na-ewere quinapril (dịka ndị ọzọ na-egbochi ACE), ọkwa potassium nwere ike ịrị elu. Iji otu oge iji quinapril nwere ike belata hypokalemia nke thiazide diuretics kpatara. N'ihi ihe egwu nke mmụba na-abawanye na ọkwa potassium, a ga-eji usoro ọgwụgwọ jikọtara ya na ọgwụ ndị na-enye ọgwụ ike na nlezianya, na-elele ọkwa potassium kwa oge.
N'ime ụfọdụ ndị ọrịa nwere nsogbu gbasara akụrụngwa ndị na-ewere NSAID, enwere ike ịkawanye njọ n'ọrụ ọrụ gbasara akụrụ mgbe mmalite nke ndị na - egbochi ACE. Ọtụtụ mgbe ọnọdụ a na-atụgharị. Enwere ike belata ya na ọgwụgwọ ọgwụgwọ nke quinapril mgbe ya na ndị NSAID na-emekọ ihe.
Ndị na - egbochi ACE, gụnyere quinapril, nwere ike ịbawanyewanye ike na insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ, nke nwere ike iduga mmepe nke hypoglycemia na ndị ọrịa nwere ọrịa mellitus. N'okwu a, a chọkwuru nleba anya.

Doụbiga ọgwụ ike Akkupro, ihe mgbaàmà yana ọgwụgwọ

Ngosiputa amamịghe nke nnabata riri nne nwere ike ibu hypotension akwara, na-achọ nlekọta nchịkwa. A na-eme Symptomatic na nkwado nkwado. Ọkpụkpụ akụrụngwa na akwara njikọ ahụ anaghị emetụta oke nke quinapril na quinaprilat.

Mwepụta wepụtara ya na ihe mejupụtara

Acupro dị n'ụdị mbadamba ihe eji eme fim; mbadamba ọ bụla nwere ọnụọgụ nke dabara na ọdịnaya nke quinapril dị n'ọrụ (5 mg, 10 mg, 20 mg ma ọ bụ 40 mg) na ya. Dị ka ihe inyeaka, nkwadebe ahụ nwere magnesium stearate, gelatin, carbon magnesium, crospovidone, lactose monohydrate. Ngwakọta nke ihe eji eme ihe nkiri nke mbadamba ụrọ gụnyere: opadry ọcha OY-S-7331 na ahịhịa.

Pharmacodynamics na pharmacokinetics

ACE bụ enzyme nke na - egbochi ntụgharị nke angiotensin nke ụdị nke mbụ na angiotensin nke ụdị nke abụọ, nke na - eme ka ụda vaskụla dịkwuo elu site na ime ka ihe nzuzo nke aldosterone nwee ume site na cortex adrenal.

Khinapril na-egbochi ACE, belata ọrụ vasopressor, izobe ihe omimi aldosterone, ma na-abawanye nnagide mmega ahụ. Site n'iji ndị ọrịa ogologo oge, ọnye ahụ na - enye isyomic myocardium mma.

Ọbara ọbara onye ọrịa ahụ na-ebelata, ngụkọta akwara mmiri na-ebelata, olu obi na-agbanwe, na-achịkwa usoro ọbara gbasara akụrụ. Ọ bụrụ na ị theụọ ọgwụ ahụ nke ọma, ọ na - eme ka ọkọnọ ọbara ọbara nye ischemic myocardium, na - eme ka ọbara na - eto eto akụrụ.

A na-ahapụ ngwa ngwa ahụ ngwa ngwa ma bido ime ihe elekere 1 ka ngwa gachara. A na-ahụta mmetụta kachasị mgbe awa 3 gachara, a na-eme ihe ahụ na-aga n'ihu kwa ụbọchị. A na-ahụ nsonaazụ ụlọ ọgwụ kwụsịrị mgbe izu 1-2 gachara iji ya oge niile. Ihe dị ka 40% nke quinapril mgbe ị doụsịrị ọgwụ ahụ na-agbasa na plasma ọbara na-agbanweghị.

Iri nri anaghị emetụta nnabata nke ihe mejupụtara. Ihe oriri dị nro nwere ike igbochi nnwere onwe nke ihe na-arụ ọrụ. Ihe dị ka 50-55% nke quinapril bụ ụmụ aka wepụrụ. A na-ekesasị ihe ndị ọzọ na plasma. Ọ bụ ya mere akụrụ na site na eriri afọ ya.

Ihe ngosi maka ojiji

A na-egosi ọgwụ "Akkupro" maka ndị ọrịa chọpụtara ụdị nsogbu ahụike ndị a:

Ọbara ọbara (akwara ọgwụ dị ka monotherapy ma ọ bụ yana yana thiazide diuretics),
Ọkpụkpụ obi, nke na-apụta n'ụdị na-adịghị ala ala (jikọtara ya na diuretics ma ọ bụ cardiac glycosides).

Dọkịta ga-ede ọgwụ ahụ ka nyochachara onye ọrịa ahụ. Can nweghị ike ị theụ ọgwụ ahụ n'onwe gị, ka ị ghara ịkpasu nsogbu ahụ ike ndị ọzọ.

A na-eji ọgwụ ahụ maka ọbara mgbali elu.

Nsonaazụ

Ọtụtụ ndị ọrịa na-akọ na isi ọwụwa, dizzness, ụkwara, ike ọgwụgwụ, rhinitis. Vomom ma ọ bụ ihe ịrịba ama nke myalgia bụ ihe kwere omume.

Nri ahụ enweghị mkpụrụ, na-adịgide, na-apụ n'anya ozugbo ọgwụgwọ nke ọgwụgwọ kwụsị. Ọ bụrụ na onye ọrịa ahụ achọpụta otu n'ime akara ndị a dị n'elu, ọ dị mkpa ịkwụsị ọgwụgwọ ozugbo. Site n'akụkụ akụkụ akwara, nkụda mmụọ, isi ọwụwa, ehighị ụra nke ọma, paresthesia, na ike ọgwụgwụ nwere ike ime.

Etu ị ga - esi mee ya, oleekwa ụdị usoro onunu ogwu a

A na-eji mbadamba Acupro ede ya ma were iko mmiri dị ọcha hichaa ya. Enweghị ike ịta ata ọgwụ ma ọ bụ kewaa ya n'ọtụtụ akụkụ. Nwere ike iwere ya tupu nri ma ọ bụ mgbe ị risịrị. Edere ọgwụ a maka ndị ọrịa nwere ọbara mgbali elu. Site na monotherapy, ndị dọkịta na-atụ aro ị initialụ ọgwụ mbụ nke 10 mg otu ugboro n'ụbọchị.

Ọ bụrụ na ọgwụgwọ ahụ ezughi oke, usoro ịba ụba ga-abawanye ruo 20-40 mg n'ụbọchị. A na-arụzigharị ihe karịrị oge 1 kwa ọnwa. Site n'ọbara mgbali elu, ị nwere ike ijikọ ọgwụ na diuretics. Usoro onunu ogwu amalite na 5 mg otu ugboro kwa ubochi. A na - eji nwayọ elu ka ọ wee rụpụta ọgwụgwọ ọgwụgwọ na-adigide.

Na nkụda obi na-adịghị ala ala, a na-enye ndị ọrịa ọgwụ ọgwụ 5 mg n'ụtụtụ na mgbede. N'oge ọgwụgwọ, onye ọrịa ahụ kwesịrị ịnọ n'okpuru nlekọta ndị dọkịta na ebe inpatient.Isi ọrụ bụ ịchọpụta na soro usoro ngosipụta nke ọgbụgba ike ọkpụkpụ. Ọ bụrụ na onye ọrịa ahụ anabata ntakịrị usoro ọgwụgwọ ahụ nke ọma, ọ na-abawanye ruo 30-40 mg kwa ụbọchị.

Mlọ ọgwụ

Site na nchịkwa ọnụ nke itinye uche kachasị (C_max) n'ime plasma ọbara, quinapril ruru n'ime otu elekere, quinaprilat metabolite ya n'ime awa abụọ. Food foodụ ọgwụ oriri n’otu oge anaghị emetụta ogo a ofụ ọgwụ a, kama ọ nwere ike ịbawanye oge iji rute C_max (nri mara abụba nwere ike belata mmịpụta nke ihe ahụ). Nyere uto nke quinapril na metabolites ya site na akụrụ, ogo nnabata Acupro bụ ihe dịka 60%.

Quinapril na-agbagha ngwa ngwa site na ịhapụ nke ester site na enzymes imeju na quinaprilat (ihe bụ isi metabolite bụ quinapril dibasic acid), ihe bụ ike ACE inhibitor. Ihe dị ka 38% nke ọgwụ a natara na ọgwụ na-agbasa na plasma ọbara n'ụdị quinaprilat.

Ihe dị ka 97% nke quinapril ma ọ bụ quinaprilat na-agbagharị na plasma ọbara n'ụdị nwere protein.

Ọgwụ a anaghị agafe ihe mgbochi ọbara-ụbụrụ.

Ọ pụtara: akụrụ nwere mmamịrị - 61% (nke n’ụdị quinapril na hinaprilat - 56%), site na eriri afọ - 37%.

Nkera-ndu (T_½) site na plasma: quinapril - 1-2 awa, quinaprilat - awa 3.

Mlọ ọgwụ ọgwụ Pharmacokinetic dị n'ọnọdụ ikpe pụrụ iche:

ọdịda ọdịda: na-abawanye T_½ n'iji mkpochapu nhichapu nke creatinine,
egbu egbu cirrhosis: ịta ahụ na-agbada (n'ihi mmebi nke mkpochapu nke quinapril),
ịka nká (ihe karịrị afọ 65): a na-ebelata mkpochapu, nke a na-ejikọkarị na nsogbu akụrụ metụtara afọ, agbanyeghị, ọdịiche dị mkpa na nchekwa na ịdị mma nke hinaprilat adịghị iche na ndị ọrịa na-eto eto.

Ogwu ogwu nke Akkupro

Ihe na - arụ ọrụ nke ọgwụ ahụ - quinapril hydrochloride, bụ ihe na - egbochi enzyme nke angiotensin, nke na - ebelata nzuzo na ọrụ vasopressor nke aldosterone, na - eme ka nnabata mmega ahụ belata ma belata nchịkọta platelet.

Site na iji ọgwụ Akkupro agbatịkwu ogologo oge, a na-ahụ mmepe mmepe na ndị ọrịa nwere ọbara mgbali elu, ọbara mgbali myocardial, ụba akụrụ na ọbara ọgbụgba, yana mmụba ọbara nye isyomic myocardium.

Ofzọ eji Akkupro

Dịka ntuziaka ahụ si dị, a na -ewere Akkupro ọnụ, na-a plentyụ mmiri buru ibu ma ghara ịta ata, n'agbanyeghị nri ahụ. Usoro onunu ogwu g’ara oria, bu:

Site na ọbara mgbali elu - 10 mg nke ọgwụ kwa ụbọchị maka ndị ọrịa na-enwetabeghị diureta na mbụ, na mmụba enwere ike ị nweta ya ruo 20 mg, kewara abụọ. Ọrịa n’otu oge edepụtara diuretics na Accupro - 5 mg nke ọgwụ otu ugboro n’ụbọchị, na-enwe mmụba na-esote ya ugboro abụọ iji rụpụta oke ọgwụgwọ dị mma,
Na nkụda obi na - adịghị ala ala - ọgwụ mbụ bụ 5 mg na otu ma ọ bụ abụọ usoro kwa ụbọchị. N'ihe banyere ezigbo ọgwụ ị ,ụ ọgwụ, enwere ike ịbawanye dose ahụ ruo 10-40 mg kwa ụbọchị, kewara abụọ,
N'ihe banyere ọrụ ezigharị nsogbu, usoro izizi na-adabere na nhichapụ creatinine, yabụ ọ bụrụ na ọ dị iche n'etiti 10-30 ml / min, a na-enye 2.5 mg nke Akkupro, 30-60 ml / min - 5 mg, na karịa 60 ml / min - 10 mg kwa ụbọchị. N'ọnọdụ ebe onye ọrịa na-anabata ọgwụ mbụ ahụ nke ọma, mmụba ya na ọkara ga-ekwe omume.

Maka ndị ọrịa mere agadi, ọgwụ a na-atụ aro ịmalite nke Accupro bụ 10 mg kwa ụbọchị, na ntachi obi dị mma, ọ nwere ike jiri nwayọọ nwayọọ mụbaa ruo mgbe a ga-enweta nsonaazụ ọgwụgwọ kachasị mma.

Ọnọdụ nchekwa

Dịka ntuziaka ahụ si dị, ekwesịrị ịchekwa Akkupro n’ebe nkụ na-echebe ya site n’ìhè na n ’iru ụmụaka, n’ọnụ ụlọ na-erughị 25 Celsius. A na-enye ọgwụ ahụ ọgwụ site na ọgwụ ọgwụ, ndu nchekwa ya, dabere na nkwenye ndị nrụpụta, bụ afọ atọ, mgbe nke ahụ gasịrị, a ga-ekpochapu Accupro.

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Mmekorita

Ọ bụrụ n were ọgwụ "Akkupro" na tetracycline, a ga-ebelata mmetụta nke ọgwụ ndị ahụ. Dọkịta ndị nyere ọgwụ lithium, chọpụtara na ndị ọrịa ịbawanye ụba nke ihe a na ọbara ọbara. Enwere ohere nke ihe ịrịba ama nke mmanya ịhiụ mmiri na lithium na ahụ gị.

Ekwesịrị iji nlezianya kpoo lithium na hinapril n'otu oge. Ndị dọkịta na-atụ aro ka ndị ọrịa dị otú ahụ nọrọ n'ụlọ ọgwụ n'okpuru nlekọta nke ndị dọkịta. Ha ga-achịkwa ịta ahụhụ nke lithium.

N'iji oge a na-eji ọgwụ mkpakọ, a na-eme ka mmetụta antihypertensive nke quinapril dịkwuo mma.

Anyị nwere ike ịmata ọdịiche dị na analogues nke ọgwụ "Akkupro" na nkọwa:

Quinafar. Edere ọgwụ a maka ndị ọrịa nwere ọbara mgbali elu, akụrụ gbasara akwara, scleroderma, nnukwu myocardial infarction. Ngwakọta ahụ gụnyere otu ihe eji arụ ọrụ - hinapril.
Hinapril-C3. Nke a bụ ezigbo analogue nke ọgwụ "Akkupro". Edere ọgwụ ahụ maka ndị ọrịa nwere ọbara mgbali elu, ike ọgwụgwụ na-adịghị ala ala (mgbe ejikọtara ya na ọgwụ ndị ọzọ).

Nwere ike ịhọrọ dochie anya onwe gị, ka ị ghara ime ka ọnọdụ ahụ ka njọ ka ị ghara ihu nsonaazụ dị njọ. Agaghị enwe ike analogs na nke ha, ọkachasị ma ọ bụrụ na enwere mmetụta na-emetụta ihe ndị dị na ọgwụ ahụ. Enwere ohere dị elu nke ọrịa angioedema.

N'ọtụtụ oge, ndị ọrịa na-anabata ọgwụ ahụ nke ọma; a na-ahụta mmelite 7-10 ụbọchị mgbe ịmalite ọgwụgwọ. Ọ dị mkpa ịgbaso ndụmọdụ niile nke dibịa na-aga, agabigala usoro onunu.

Ntuziaka Accupro maka njiri nyocha nyocha

Usoro akwadoro ibido bụ 2, Ahịa maka, nkọwapụta. (quinapril). , ọnụahịa dị na ụlọ ahịa ọgwụ, ihe mejupụtara, na-egosi. N'ime, na-adịghị ata ata, n'agbanyeghị oge nri, jiri mmiri sachaa ya. Mgbe nchịkwa ọnụ cmax gasịrị, a na-enweta quinapril na plasma n'ime elekere 1. Usoro. Edemede a kọwara mmetụta ọgwụ ọgwụ, ,-- ozi zuru oke gbasara ọgwụ. Ekwesịrị ịkwụsị onye ọrịa ahụ ozugbo., Pricegwọ dị na ahịa ọgwụ, ihe mejupụtara, na-egosi. Ofdị ntọhapụ na ihe mejupụtara Ngosipụta nke ọrụ ezigharị nsogbu, azotemia,., Ngosipụta maka, usoro, mmetụta ndị ọzọ, contraindications, afọ ime,. Nleghari anya iji mee ihe .. A na-enyocha nyocha, ana-egosi ntụpọ. Nkọwa nkọwapụta maka usoro contraindications nke iji ya na akụkụ mmetụta ọ bụla.

Ntuziaka Accupro maka ojiji - Ntuziaka Accupro maka iji acupro price acupro - piluli

Ejila doses abụọ nke ihe ahụ n'otu oge: mmemme bara uru maka gam akporo. Akụkọ banyere ọrịa ụbụrụ angioneurotic, nke ejikọtara ya na ọgwụgwọ nke APF inhibitors nwere mmetụ dị ukwuu maka akụkụ nke ọ bụla.

Ọ bụrụ na echefuru ị aụ ọgwụ ngwaahịa a, were ya ozugbo, ka ị na-anwa icheta, na-echeghị oge na-abịa maka iwere ngwaahịa a. Nsonaazụ antihypertensive nke quinapril nwere ike ịbelata na nhọpụta nke ọgwụ mgbochi na - abụghị steroidal anti-inflammatory ma na - abawanye na usoro antipsychotics, narcotic analgesics, diuretics, antihypertensives ndị ọzọ, iji ọgwụ na - emechi ọgwụ na - egbu mmụọ.

Ntuziaka Accupro maka ojiji

Ederede na-adọrọ mmasị: -> ibudata ndị na-agụ kọmputa maka android

-> atụmatụ nke modami origami swans

-> budata ụdị ọkpụkpọ zuru oke na android

-> eserese usoro mbara igwe

-> ntuzizi izipu ihe

International Nonproprietary Aha

Aha Latin nke ọgwụ: Accupro. INN: Quinapril.

Ọgwụ antihypertensive, ACE inhibitor. Koodu ATX: C09A A06.

Weputara udi ya na ihe mebere ya

Odikwa n'ụdị agba, triangular ma ọ bụ oval, mbadamba ihe mkpuchi na-acha ọcha ma ọ bụ ọbara ọbara. Otu mbadamba 1 nwere 5, 10, 20 ma ọ bụ 40 mg nke ihe na - arụ ọrụ - quinapril n'ụdị hydrochloride, yana ndị nwere ọgwụ. Mpempe kaadiboodu nwere blisters 3 ma ọ bụ 5, nke ọ bụla nwere mbadamba 6 ma ọ bụ 10.

Ọgwụ na-egbochi mmụọ nke na-egbochi ọrụ enzyme nke angiotensin, yana ntinye nke angiotensin nke m gbanwere ịbụ angiotensin II. Nke ikpeazụ bụ akụrụngwa endogenous na-eme ka ọbara mgbali elu na-arụ ọrụ. Mbelata na secretion nke ogige a na - eme ka mgbakwunye sodium excretion na oge na - egbu oge n'ime ahụ, nke na - ebelata nguzogide arịa arịa ma na - ebelata ọbara mgbali elu. Site n'iji ya eme ihe oge niile, ọ na - enyere aka belata usoro oke imechi akwara obi na akwara ọbara, nke na - ebulite mbido ọbara mgbali elu.

Mgbe nchịkwa ọnụ gachara, etinyere mkpokọta quinapril na ọbara n'ime nkeji 60-90. Ọ dịkarịa ala 55% nke ọgwụ na-etinye.

N'okpuru ọrụ nke enzymes imeju, a na-eme ka ihe dị n'ime bụ metabolized ka quinaprilat, nke bụ ihe dị ike na-egbochi ACE. Ya sistemu bioavailability dị 35%.

Ihe dị n’ime ya na metabolites ya abanyeghị na mgbochi ụbụrụ ọbara na-ewepụta site na akịrị site na akụrụ. N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, iwepu ọkara ndụ na-abawanye site na mbelata nwebisi creatinine.

Ihe ngosi maka ojiji

Edere ọgwụ ahụ maka ọgwụgwọ ọbara mgbali elu akwara na nkụchi obi na-adịghị ala ala.

Ihe ogwu ahu bu nke anakpo onodu oria na onodu ndia:

hypersensitivity na akụkụ ọ bụla
akụkọ banyere ọrịa angioedema n'ihi ọgwụgwọ mbụ ya na ọgwụ antihypertensive ma ọ bụ ihe ketara eketa na / ma ọ bụ ọrịa nfụkasị,
enweghị lactose, glucose-galactose malabsorption.

Eji ya jiri nlezianya mee ka ọnụnọ nke ọrịa na ọnọdụ dị otú a:

hypotension artpotomatic hypotension, ọkachasị ndị ọrịa bụ ndị buterela diuretics ma soro nri nwere obere nnu,
nnukwu ọrịa n'ihi dysfunction dysfunction nke akwara obi,
ọrịa shuga mellitus
akụrụ ma ọ bụ imeju akụrụ,
autoimmune connective anụ ahụ,
oke ikuku
hyperkalemia
belata n'ọbara ọbara.

Na mbido ọgwụgwọ, a na-atụ aro iji ọgwụ a dabere na nyochaa njikwa ọbara.

Ejiri jiri nlezianya mee ya tupu ọnụnọ nke imeju.

A na-eji mkpachapụ anya na ọnụnọ nke hypotension akwara.

A na-eji mkpachapụ anya na ọnụnọ nke ọrịa shuga.

Ejiri akọ na ọnụnọ nke ọdịda akụrụ.

A na-eji mkpachapụ anya na ọnụnọ nke hyperkalemia.

A na-eji mkpachapụ anya na ọnụnọ nke akwara ọbara.

Eji ya jiri nlezianya mee ihe tupu mbelata olu nke na-ekesa ọbara.

Uzo esi ewere Accupro

Edebere ọkachamara na oge usoro ya na usoro ahụ, na-ebido ịchọpụta nchoputa na njirimara onye ọrịa ahụ. A na-ewere ọgwụ ahụ ọnụ, n'agbanyeghị nri oriri, 0.01 g 1-2 ugboro n'ụbọchị. Na enweghị ụgwụ ọgwụgwọ dị mkpa, enwere ike ịbawanye otu nari ugboro abụọ, mana ọ gafere ogo ọgwụ 0.08 g kwa ụbọchị. O kwere omume ị aụ ọgwụ kwa ụbọchị otu ugboro, na-enweghị kewaa ọtụtụ usoro.Nwere ike ịbawanye dose ahụ naanị na nkwenye nke dibịa bekee ma ọ bụghị tupu izu anọ site na mmalite ọgwụgwọ.

Na-arịa ọrịa shuga

A na-eji ọgwụ ahụ eme ihe dị ka akụkụ nke usoro ọgwụgwọ zuru oke, na-achọpụta njikwa glycemic nke ọma na usoro usoro ị recommendedụ aro a tụrụ aro ya.

Ọgwụ ọgwụ ahụ anaghị akpata mmeghachi omume achọghị. Ọtụtụ mgbe, a na-ahụ ya megide nzụlite nke inwekwu uche yana akụkụ ya ma ọ bụ mgbe a chọpụtaghị usoro ọgwụgwọ a tụrụ aro. Okwesiri ka onye okacha mara ka o nyechaa ogwu ahu ka o gha eme ya.

Akara nke akpụkpọ ahụ mucous nke ọnụ ma ọ bụ akpịrị, ọnyụnyụ dyspeptik, ọgbụgbọ, ihe mgbu nke afọ, ibelata agụụ, na imebi echiche ụtọ.

Sistemụ akwara Central

Na-agbaso usoro ị drugụ ọgwụ ahụ, mgbanwe ọnọdụ, vertigo, nsogbu asthenic, ike ọgwụgwụ ma ọ bụ mgbakasị ahụ, enwere ike ịmịcha anụ ahụ nke ọnụọgụ na mgbanye.

Nsonaazụ nke ọgwụ nwere ike ịbụ mbelata agụụ.

Nsonaazụ nke ọgwụ nwere ike ịbụ mgbanwe nke ụtọ.

Nsonaazụ nke ọgwụ nwere ike ịba ụba ike ọgwụgwụ.

Mmetụta dị n'akụkụ ọgwụ ahụ nwere ike ịbụ akọrọ ọnụ.

Mmetụta dị n'akụkụ ọgwụ ahụ nwere ike ịbụ mgbanwe ọnọdụ.

Mmetụta ọzọ ọgwụ nwere ike ịbụ diski diski.

Nsonaazụ ọzọ nke ọgwụ ahụ nwere ike ịbụ ọrịa akpachapụ anya nke akpịrị na ọnya.

Site na usoro urinary

N'ọnọdụ ndị dịpụrụ adịpụ, a na-ahụta ọrịa ọnya.

Site na sistem iku ume

Ọtụtụ mgbe enwere ụkwara na-ekweghị akwụsị akwụsị, nke na-adịghị amị mkpụrụ nke na-agafe mgbe a kwụsịrị ọgwụgwọ, mmetụta nke enweghị ikuku, nnukwu mbufụt nke mucosa pharyngeal, mgbu obi.

Na anụahụ

Akpukpo anụ ahụ na mmeghachi omume anụ ahụ ga - ekwe omume, dịka ịba ụba ọsụsọ, nkọcha na nkụda mmụọ, ihe ọkụ ọkụ, itching, ntutu isi na - egbu egbu, pemphigus, mmeghachi omume mpaghara ma ọ bụ sistemụ.

Site na usoro mkpụrụ ndụ ihe nketa

N'ọnọdụ ndị a na-adịghị ahụkebe, mbelata ikike, urination na-egbu oge ga-ekwe omume.

Si na akuko obi

Enwere ike imeghachi omume nke akụkụ ahụ dị na ọbara, dị ka mbelata nke ọnụ ọgụgụ ọbara ọbara ọbara n'ime ọbara, mbelata nke ọbara haemoglobin, agranulocytosis, mbelata nke ọtụtụ platelet, na ụkọ nke ụdị sel sel niile.

N’akụkụ nke usoro akwara obi, mmeghachi omume ndị a na - adịghị mma dịka mbelata ọbara mgbali, mgbakasị ahụ n’apata obi, obi mgbawa, ịma jijiji, tachycardia, na mmụba nke akwara ọbara.

Site na anụ ahụ na akwara

Ọtụtụ mgbe enwere mgbu azụ. N'ọnọdụ ndị na-adịghị ahụkebe, megide ndabere nke iji ọgwụ ahụ, ọrịa nkwonkwo na-emebi emebi.

Mmetụta dị n'akụkụ ọgwụ ahụ nwere ike ịbụ ụkwara.

Nsonaazụ nke ọgwụ nwere ike ịbụ ntutu isi.

Nsonaazụ nke ọgwụ nwere ike ịbụ azụ mgbu.

Nsonaazụ nke ọgwụ nwere ike ịbụ mgbu mgbu.

Mmetụta dị n'akụkụ ọgwụ ahụ nwere ike ịbụ ọrịa ọrịa urinary.

Nsonaazụ nke ọgwụ nwere ike ọzịza nke ihu.

Site na usoro ahụ ji alụso ọrịa ọgụ

Mmeghachi anaphylactoid, angioedema enwere ike.

Ọ bụrụ na ọgbụgbaji na - emegharị ma ọ bụ ihe na - emegharị nke dị n'okpuru ihu, ire ma ọ bụ ụda olu, ekwesịrị ịkwụsị ọgwụ ya ozugbo. Ọ bụrụ na ire azụ ma ọ bụ ogwooro na-achọ imebi ikuku ikuku banye na ngụgụ, ọgwụgwọ mberede na nlebara anya zuru oke tupu ịmalite imepe ihe mgbaàmà nke nfụkasị.

Mmetụta ikike ịchịkwa usoro

Mgbe ị na-a theụ ọgwụ ahụ, e kwesịrị ịkpachara anya mgbe ị na-achịkwa usoro na ịrụ ọrụ chọrọ nlebara anya, karịchaa na mmalite ọgwụgwọ, n'ihi nnukwu ọnya ọgbụgba na hypotension.

Oge nri n’otu oge emetụtaghị ogo ị ofụ ọgwụ, kama ọ na-abawanye oge iji ruo n’uche kachasị nke ihe arụ ọrụ.

Mgbe ị na-a medicationụ ọgwụ, a na-atụ aro ịhapụ nri ndị mara abụba na nri.

N'ọnọdụ ụfọdụ, ọgwụgwọ na angiotensin-na-agbanwe enzyme inhibitors na mmepe nke hypoglycemia na ndị ọrịa nwere ọrịa mellitus, na-a oụ ọgwụ hypoglycemic nke ọnụ ma ọ bụ na-enweta insulin. Ihe na-arụ ọrụ nke ọgwụ ahụ na-eme ka ihe insulin na ndị ọrụ antidiabetic nwee ọrụ.

Jiri n'oge ime na lactation

Contraindicated na ime na lactation.

Oge ọkwa Akkupro nye ụmụaka

Ejighị ọgwụ ahụ na omume ụmụaka n'ihi enweghị data na nchekwa ya na arụmọrụ ya.

A na-egbochi ọgwụ ị inụ ara.

Ejighi ogwu a mee ihe banyere umuaka.

A na-egbochi ọgwụ a n'afọime.

Jiri na agadi

Anabatara ya maka ojiji na-enweghị contraindications. Usoro akwadoro ọgwụ mbụ bụ 10 mg otu ugboro n'ụbọchị. N'okpuru nlekọta nke dibia bekee, enwere ike ịbawanye elu iji nweta mmetụta ọgwụgwọ chọrọ.

Ngwa maka ọrụ ezughi oke ọrụ

N'ime ndị ọrịa nwere ọrụ anụ ahụ, a na-achọpụta mmụba na ọkara ndụ nke ihe na-arụ ọrụ, ya mere, ọ dị mkpa iji dozie dose ahụ, na-eburu n'uche njirimara nwepu ihe njikwa. Oke onunu ogwu kachasị site na 2.5 ruo 10 mg kwa ụbọchị. Thebawanye oke nke ọgwụ ahụ ga - ekwe omume naanị n'okpuru nchịkwa nke ọrụ anụ ahụ. Ọ bụrụ na ịhapụ itinye ndụmọdụ ahụike nwere ike iduga nsị anụ ahụ, gụnyere ihe ọghọm nke ịmalite nnukwu nsogbu gbasara akụrụ.

Mgbaàmà nke ịdoụbiga mmanya ókè bụ mmebi nke nguzo mmiri-electrolyte, arrhythmia siri ike, mbelata ugboro ugboro nke mkpịsị obi, na nkwarụ anya. A na-eme ọgwụgwọ site na nchịkwa ọgbụgba nke agbanwe agbanwe plasma iji bulie olu nke mgbasa na-ekesa. Ojiji nke usoro ọgwụgwọ dialysis nwere mmetụta a na-eleghara anya na mpụta nke ihe na-arụ ọrụ. N'ọnọdụ nke mbelata ọbara mgbali, ọgwụgwọ na nkwado na-akwado ya dị mkpa.

Mgbaàmà nke ịdoụbiga mmanya ókè bụ mmebi nke nguzo mmiri-electrolyte.

Symptomsụbiga ihe ọdoụ Overụ ókè bụ nnukwu arrhythmia.

Mgbaàmà nke ịdoụbiga ókè bụ nsogbu anya.

Mmekọrịta na ọgwụ ndị ọzọ

Ojiji nke ọgwụ mgbochi tetracycline na ọgwụ mgbochi ihe na -echeta nnabata nke tetracyclines. Usoro ọgwụgwọ na nkwadebe lithium na ndị na-egbochi ACE na-eme ka ọdịnaya lithium dịkwuo elu, na-abawanye ohere nke ịxụbiga mmanya ókè. Nkwadebe nke potassium na - eme ka ihe ndị na - eme ihe na - eme ihe na - eme ihe na - eme ka ọ dịkwuo elu ma na - eme ka ọgwụ na - eme ka ọ dịkwuo mma. Ejikọtara ọgwụgwọ na ọgwụ ndị na-egbochi ọrụ ụmị ọkpụkpụ na-eme ka ohere nke ọrịa ọbara dịkwuo ala, gụnyere mbelata mkpokoro nke granulocytes na neutrophils.

Oge nchịkwa nke ọgwụ nwere hinapril na Allopurinol, Novocainamide, ndị na-ahụ maka cytostatic ma ọ bụ immunosuppressants na-abawanye ohere nke ịmalite leukopenia. Ọgwụ antihypertensive, ọgwụ maka izizi, ọgwụ opioid na-akwalite mmetụta hypotensive nke quinapril, ebe ọgwụ mgbochi ọgwụ steroidal na-eme ka ike gwụ ya n'ihi njigide mmiri n'ime ahụ.

Mmanya ndakọrịta

Ethanol kwalite mmetụta antihypertensive nke ọgwụ.

Ọgwụ nwere ọtụtụ analogues nke nọ n'otu otu ọgwụ. Themfọdụ n’ime ha bụ:

Ihe dị ọgwụ a na-arụ ọrụ nwere ike ịdị iche, yabụ, dochie ọgwụ a ga-ekwenye na dọkịta.

Ọgwụ Prestarium maka ọbara mgbali elu

Usoro ezumike Acupro sitere na ụlọ ahịa ọgwụ

Purchasezụta ọgwụ na-egbochi ihe mgbochi, ịkwesịrị ịhọrọ dọkịta.

Enwere m ike ịzụta na ndenye ọgwụ

Relelị site na ndenye ọgwụ.

Ọnụahịa Acupro

Ọnụ ego otu ọgwụ bụ 535-640 rubles.

Ọnọdụ nchekwa maka ọgwụ

Chekwaa na ụlọ okpomọkụ a na-achịkwa (ọ dịghị elu karịa + 20 Celsius C). Zere ìhè anyanwụ. Belata ohere ụmụaka nwere ị medicineụ ọgwụ.

Ọnwa iri atọ na isii gachaa ọgwụ ọ nabatabeghị.

Nyocha maka Akkupro

Tupu ị theụ ọgwụ antihypertensive, a na-atụ aro ka ị gụọ nyocha nke ndị ọkachamara ọgwụ na ndị ọrịa.

Alevtina Ivanova (dibia akwara), 39 afọ, Ivanovo

Ọgwụ dị irè emebere iji belata ọbara mgbali elu ma melite ọrụ obi. Ogologo oge na-enyere aka ime ka mgbidi nke akwara gbasie ike, melite ike ha. A na-enye ọgwụ ahụ dịka ọgwụ si dị, yabụ, ọkachamara kwesịrị ịkọwa ọgwụgwọ ziri ezi iji kpochapụ contraindications enwere ike belata ihe ize ndụ nke ịmalite mmeghachi omume achọghị.

Ndị ọrịa na-a theụ ọgwụ ahụ

Alina, gbara afọ 43, Krasnoyarsk

Anakwere dika edebere ya otutu ọnwa. Irè ọgwụ ahụ dị elu, nrụgide ahụ na-alaghachi na nkịtị mgbe awa 1-2 gachara. Agbanyeghị, ọ manyere ya ịhapụ usọbọ a n'ihi mmetụta ọjọọ ọ na-akpata - mwakpo nke ụkwara.

Anna, gbara afọ 28, Perm

Choputa ihe omuma gi nke ibute oria shuga!

Nweta nnwale na ntanetị n'efu n'aka ndị endocrinologists nwere ahụmahụ

Oge nnwale erughi nkeji abụọ

puku ule ịga nke ọma

Mama m ogologo oge gbalịrị ịnagide ọbara mgbali elu na aka ya, mana ịdị irè nke usoro ndị mmadụ adịteghị aka. Aghaghị m ịhụ dọkịta. Edere Mama a ọgwụ maka na ha chọpụtara nkụda obi. Mgbe ọgwụgwọ ya gasịrị, ndị na-egosi nrụgide laghachiri na nkịtị, ihe ịrịba ama nke ọbara mgbali elu na-apụ n'anya. Enweghị mmetụta dị njọ ọ bụla, ọ dịghị mkpa ka ịgbanwee ndị analogues ndị ọzọ dị oke ọnụ ma nwee mmeghachi mmetụta dị ole na ole.

Ọgwụ "Kaptopres" na-ezo aka na ndị ọrụ dị mgbagwoju anya, nke nwere ihe abụọ na-arụ ọrụ: captopril - angiotensin-na-agbanwe enzyme inhibitor na diuretic hydrochlorothiazide. Ọgwụ na-egosipụta a hypotensive na diuretic mmetụta. Emepụtara ya n'ụdị mbadamba maka nchịkwa ọnụ site n'aka ụlọ ọrụ ọgwụ Ukraine bụ Darnitsa.

Enwere ụzọ abụọ nke ọgwụ ahụ, na-adị iche na ọnụ ọgụgụ nke ihe ndị mejupụtara. Mbadamba ụrọ maka nrụgide "Kaptopres" nwere 50 mg nke captopril na hydrochlorothiazide 25 ma ọ bụ 12.5 mg. Ihe ndi ozo bu povidone, shuga mmiri ara ehi, aerosil, stachite nduku na steeti magnesium.

Maka ọgwụ "Kaptopres" ọnụahịa ahụ sitere na 180 rubles kwa ngwugwu. Ọnụ ego ahụ dị ala karịa ọgwụ ndị ọzọ na-ebelata ọbara mgbali elu, nke na-ebelata ịdị irè ya. Na mba nke onye mepụtara maka ọgwụ "Kaptopres" ọnụahịa ahụ ruru 89 rubles kwa otu nwere mbadamba iri abụọ.

Kedu ka ọgwụ ahụ si arụ ọrụ?

Ngwa ndị nọ n'ọrụ na-ekpebi usoro nke ọgwụ "Kaptopres", nke na-ekpebi nsonaazụ ya na ahụ mmadụ.

Obi ọ̀ na-afụ ụfụ mgbe niile?

Site na igbochi angiotensin n'ịtụgharị enzyme captopril, a na-ebelata njikọ nke ụdị angiotensin ụdị 2. N'okpuru mmetụta nke homonụ oligopeptide a, arịa dị warara, a na-akpali mmepụta nke aldosterone site na eriri mmiri adrenal.

Mbelata angiotensin nke ụdị nke abụọ na-ebelata nrụgide na akwara akwara, na atrium dị mma, arịa na - akpụgharị akwara, ihe na - egosipụta ngụkọta akwara nke akwara, na ibu ahụ. Knowingmara njiri mara captopril, ị nwere ike ikpebi nsonaazụ nke ọgwụ "Captopres", n'oge nrụgide ị toụ ọgwụ a.

N'ihi hydrochlorothiazide, a na-enwe mmetụta dị ala na urinary sistem site na iwepu ụmụ irighiri mmiri, chloride, potassium na sodium ion site n'ahụ ahụ.Ihe ahụ nwere ike belata ọkwa sodium na mgbidi arịa ahụ, na-eme ka ọ bụrụ ihe na-emetụtaghị mmetụta vasoconstrictor, ma bulie mmetụta antihypertensive nke captopril.

Mbadamba ụrọ Kaptopres: gịnị ka ha na-enyere aka?

Ọgwụ na-ewepụ ọbara mgbali elu nke akwara dị iche iche, gụnyere ọbara mgbali oke na -eche ọgwụ ndị ọzọ.

Site n'enyemaka nke ngwá ọrụ a, a na-arụ ọrụ nlekọta mberede n'oge nsogbu ọbara mgbali elu.

Iji nyere ọgwụ ahụ aka, ọ kwesịrị ị drunkụ mmanya naanị mgbe ọ nwesịrị nrụgide ahụ.

Ọ dị mkpa ịmata mgbe ị ga-ewere mbadamba Kaptopres. Ihe ngosi maka iji ogwu a gunyere:

ọbara mgbali elu dị mkpa, nke na - ebilite n'ihi ihe dị iche iche anaghị emetụta ọrịa ahụ.
ọbara ọgbụgba na -akpata, nke bụ akara nke ọtụtụ ọrịa,
obi ọjọọ ọbara mgbali na angina ọgụ ma ọ bụ nkụda obi,
Ọrịa ọbara ọgbụgba na-emetụta nsogbu arịa akụrụ,
ọbara ọgbụgba renoparenchymal yana ụdị ọrịa glomerulonephritis dị ala na nke na - adịghị ala ala nke etiology,
ọbara mgbali elu na ụkwara ume ọkụ bronchial,
ọrịa shuga,
obi ogbako, mgbe obi ike adighi ike
Ọrịa Conn nwere ụdị hyperaldosteronism kachasị.

A na-eji ọgwụ ahụ eme ihe maka nlekọta ahụike mberede maka nsogbu ọbara mgbali elu.

Etu ị ga-esi

Ọ dị mkpa ịkpachapụ anya na mbadamba ụrọ Kaptopres. Kedụ nsogbu m kwesịrị ị takeụ ọgwụ ka ọ ghara imerụ ahụike m? Ajụjụ a ka ọtụtụ ndị ọrịa nwere ọbara mgbali na dọkịta ha.

Elele, 120/80 mmHg ka a na-ahụ anya na-egosi nrụgide nkịtị. Art. N'ihe dị elu, a ga-eme ihe iji belata ọbara mgbali. Ọ bụrụ na edepụtara ọgwụ Kaptopres maka ndị ọrịa maka nrụgide, ọ ga-a beụ ihe ọ 60ụ aụ nkeji 60 tupu nri tupu ịghara ịkpaghasị nnabata nke mmiri dị n'ọrụ. A na-ahọrọ usoro ọgwụgwọ dabere n'ụdị ọbara mgbali elu na ogo nke onye ọrịa ọ bụla n'otu n'otu.

Ọgwụgwọ kwesịrị ịmalite site na ọkara mbadamba, nke nwere captopril 25 mg na hydrochlorothiazide 12.5 mg. Ọ drunkụbigara mmanya ókè 1 otu ụbọchị. Maka usoro mmezi n'ihu, a ewerelarị mbadamba mbadamba ụbọchị kwa ụbọchị na ọnụego captopril na 50 mg na hydrochlorothiazide na 25 mg. A na-ahụkarị ọgwụgwọ ọgwụgwọ kachasị elu mgbe ọnwa 1.5-2 sitere na ojiji izizi. A na-eme mmezi onunu ogwu n'iji oge izu isii, na-eburu n'uche mkpa ọ dị maka mgbanwe ngwa ngwa ya.

Mbelata nke ọbara mgbali elu ezughi oke nwere ike ịbụ ihe kpatara ntinye aka na usoro ọgwụgwọ ọzọ nke captopril na hydrochlorothiazide, nke a na-ewere dị ka akụkụ nke nkwadebe otu. Onu ogugu onodu ogwu nke ubochi kwesiri ibu ihe kariri 150 mg, na ntinye nke hydrochlorothiazide - kariri 50 mg.

Iji kwụsị nsogbu ọbara ọgbụgba, m na-eji otu mbadamba ụrọ, nke a na-ata ata ma na-echekwa ya n'okpuru ire.

Ọrịa Urinary

A na -emepụta mgbakwunye nke captopril na hydrochlorothiazide site na iji akụrụ. Nmebi nke aru nke aru a (ya na uzo nke mejuputara 30-80 ml n’ime otu nkeji) na - eduga n’enwe onu ike nke mbadamba ihe n’arum.

Iji mezie ọnụọgụ nke ihe ndị na-arụ ọrụ na ndị na-ahụ maka ọgwụgwọ, were ọkara mbadamba ụbọchị kwa ụbọchị, nke kwekọrọ na ego nke captopril 25 mg na hydrochlorothiazide 12.5 mg. Na-a takeụ ọgwụ gị n'ụtụtụ 1 awa tupu nri ụtụtụ.

Mpempe akwụkwọ Kaptopres na-agwọ ọbara mgbali elu na nkụchi obi, ihe mbụ mejupụtara, captopril, bụ nke izizi na 70s nke narị afọ gara aga. Ọtụtụ ndị ọrịa na-ekwu maka abamuru nke ọgwụ ahụ, na site n'enyemaka ya, ọbara mgbali ga-agbada ngwa ngwa n'oge nsogbu ọbara mgbali elu.Ọ dị mkpa ịillsụ ọgwụ n'ụzọ ziri ezi yana oge niile iji nweta nsonaazụ dị mma.

N'ime ọtụtụ ọmụmụ ọgwụ gbasara ọgwụ ndị a na-ahụ maka ọrịa mkpụrụ okirikiri, a chọpụtara na ha na-agbada ọbara mgbali elu ma belata ọnụ ọgụgụ nke ọrịa site na ọrịa obi.

Isnye bụ contraindicated na ọgwụgwọ

Ntụziaka ọgwụ ọgwụ Kaptopres maka iji ya gụnyere ọtụtụ contraindications, nke gụnyere ịbawanye ụba nke mmadụ na-arụ ọrụ nke mbadamba ihe, angiotensin na-agbanwe enzyme inhibitors na usoro sulfamide.

You nweghị ike iji ọgwụ ahụ na stenosis nke akwara na-eduga na otu akụrụ ma ọ bụ akụrụ abụọ, mgbe ọ gbasesịrị akụkụ a, yana mmebi iwu dị ukwuu n'ọrụ ya, mgbe ọnụego ọbara ọcha sitere na creatinine bụ 30 ml kwa minit 1, na ntinye ya na plasma adịghị karịa 1, 8 mg kwa 100 ml.

Ejighi ogwu a mee ihe site n’aka ndi obia nwere ihe iriba ama nke hyperaldosteronism, mbelata nke potassium na sodium ion n’ime obara, hypovolemia, gout na hypercalcemia, ihe na - egbochi mgbanwe aortic stenosis na oke obara nke obara n’aputa aka ekpe. Amachibidoro ị theụ ọgwụ ahụ n'oge ọrịa ọrịa imeju siri ike, ụmụ nwanyị dị ime na ndị na-enye nwa ara. Contraindication bụ ụmụaka na-erubeghị afọ 18.

A na-akwụsị ọgwụ a na-eji ihe ọ takingụ takingụ were ụbọchị atọ tupu ojiji nke isi ọgwụ na ọgwụ diuretic.

Ọkachasị mkpa nke ndị okenye, ndị na-anya ụgbọ ala, ndị ọrịa immunocompromised ndị nwechara ikikere ya bụ 30-60 ml kwa 1 nkeji, protin na-abawanye na mmamịrị na ụkpụrụ ya gafere 1000 mg kwa ụbọchị.

Ikwesiri ịkpachara anya mgbe ị na-ewere procainamide, nkụchi obi, ọrụ na-arụ ọrụ na-arụ ọrụ nke ukwuu, ọrịa shuga, mgbali elu na akwara akwara. Iji nyochaa ọnọdụ ahụike nke onye ọrịa, a na-edenye ọ̀tụ̀tụ̀ mgbali nrụgide kwa oge, yana ọrụ akụrụ na ọkwa electrolyte.

Mgbe ị na-akwado nkwadebe ahụ Kaptopres, nkuzi ahụ na-akọwapụta ihe mere na ụfọdụ ndị ọrịa nke mmeghachi omume ọjọọ dị iche iche na-emetụta usoro dị iche iche nke ahụ.

Site na mmetụta na-adịghị mma na nri na ngụgụ, agụụ na-ebelata, akpụkpọ ahụ mucous nke oghere a na-akpọ nkụ, ị nwere ike ịhụ ọgbụgbọ, ọgbụgbọ, ihe mgbu na afọ, oche oge, mmepe nke stomatitis, ọnya afọ, ọrịa ala, ọrịa ịba ọcha n'anya, mụbara bilirubin na ọbara.

Mmetụta obi, akwara ọbara na ahụ haemopoietic nwere ike ime na tachycardia, angina pectoris, ọbara mgbali ala ala, ọrịa Raynaud, redness ma ọ bụ pallor nke anụ ahụ, cardiogenic shock, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic or aplastic anemia.

Ọgwụ nwere mmetụta na sistemụ akwara na-emebi usoro ihi ụra, ọhụụ na uto, mgbasa ụbụrụ, na-akpata isi ọwụwa, mwakpo nke ọgbụgba, obi nkoropụ, ọgba aghara, akwara nke aka.

E gosipụtara nsonaazụ na sistem iku ume site na ụkwara, ọdịda iku ume, bronchospasm, rhinitis nfụkasị.

A na-egosipụta nsonaazụ ndị dị na sisteemu site na ọdịda akụrụ, polyuria, oliguria, ọrịa nephrotic.

Ọrịa nwere ike ibilite n'ụdị ọnya ọnya, itching, urticaria, ede ede Quincke, Stevens-Johnson syndrome, photoensitivity, erythema.

Maka ọtụtụ ndị ọrịa, ọ dị mkpa ịmata ka Kaptopres si arụ ọrụ, n'oge nrụgide ị ga-ewere ya. Ọtụtụ mgbe ọgwụ na-a drunkụ mmanya mgbe ọbara mgbali biliri, nke na-adịghị mma. Anyị chọrọ usoro ọgwụgwọ dị ka ndụmọdụ nke dọkịta si dị.

N'oge ọgwụgwọ, ịta elektrolyte, ọkachasị ion potassium, a ga-enyocha ọnụọgụ nke creatinine na urea kwesịrị ilebara ọnụọgụ ọbara nke mpaghara mpaghara anya.

Mgbe ị na-a theụ ọgwụ ahụ, ị kwesịrị iri nri nke nwere obere sodium ọdịnaya, a na-egbochi mmanya.

Inwe mmetụta diuretic, ọgwụ ahụ nwere ike ime ka ọnọdụ nke mmiri mmiri elektrik na-echegbu onwe ya jikọtara ya na usoro ọgwụgwọ diuretic, afọ ọsịsa, vomiting, nri nwere obere sodium, hemodialysis, na-akpata hypotension akwara. Tupu usoro ọgwụgwọ antihypertensive, ọkwa nke electrolytes dị na ahụ kwesịrị idozi.

A na-enye ndị ọrịa nwere nsogbu ahụrụ na ọrịa agadi na mbadamba ụrọ Kaptopres. N ’ike dị a shouldaa ka m ga-a theụ ọgwụ ka ihe ọ rụpụtara ghara ịdalata? Tupu ị theụ ọgwụ, o kwesịrị ịchọpụta ọbara mgbali, ọ dịkwa mkpa iji nyochaa ọrụ akụrụngwa, ọdịnaya nke ion dị mkpa.

A na-ahụta agbụrụ Neroid dị ka ihe na-eguzogide ọgwụ nke na-egbochi enzyme angiotensin na-agbanwe, ọ bụ ya mere captopril nwere mmetụta dị ala na ndị ọrịa dị otú ahụ.

N'ime ọgwụ ndị na-enye ọgwụ nje na-egbu oge, “Kaptopres” nwere otu n'ime ebe eduga: ntuziaka maka iji maka nrụgide depụtara ya iji kwalite ọbara mgbali elu na iji belata ihe mgbaàmà karịsịa n'oge nsogbu ọbara mgbali elu.

N'okpuru, anyị na-enye nyocha dị mkpirikpi nke ọgwụ ahụ, na-enyocha n'ụzọ zuru ezu na ndụmọdụ nke ndị ọkachamara banyere iji ya.

"Kaptopres": njiri mara ọgwụ ahụ

Ihe ndị nọ n'ọrụ na ụdị ntọhapụ

Ọgwụ "Kaptopres" dị na ụdị mbadamba. A na-enye mmetụta dị mgbagwoju anya site na ọnụnọ nke ihe abụọ bụ isi:

captopril - onye na - egbochi ACE (angiotensin na - agbanwe enzyme),
hydrochlorothiazide - onye nwere diuretic.

Kaptopres bụ ọgwụ eji ahọrọ oke kachasị nke ihe mgbochi ACE (captopril) yana diuretic (hydrochlorothiazide).

Usoro onunu ogwu nke mbadamba:

50 mg captopril
25 mg hydrochlorothiazide.

Na mgbakwunye na ihe ndị a, ihe mejupụtara ọgwụ ahụ gụnyere silicon dioxide, magnesium stearate, stachi na ihe inyeaka ndị ọzọ.

Mmetụta nke ọgwụ ọgwụ bụ n'ihi ọrụ nkwonkwo nke ọgwụ ọgwụ na-egbochi ACE, yana diuretic:

N'ihi ihe omume nke captopril, ike nke mmetụta nke angiotensin-2 na mgbidi nke arịa ọbara na-ebelata. Nguzogide ọbara na-erugharị n’ime arịa ndị ahụ na-ebelata, nke a na-eduga n’ibelata akara ọbara mgbali elu.
Na myirịta, n'okpuru mmetụta nke isi akwara, itinye uche na plasma nke ihe ndị ọzọ na-ebelata, na-eduga n'ịbelata oghere nke ọbara (ọkachasị norepinephrine). Dika odi, a na-eme ọnọdụ maka iwelata nrụgide dị ukwuu. Nrụgide dị n’ọkpụkpụ azụ na akwara ọbara na-ebelata, wee si otú ahụ mepụta ọnọdụ maka mbelata ọbara mgbali elu.
Diuretic ahụ bụ akụkụ nke Kaptopres na-eme ka mmetụta ACE inhibitory nwee ike. Mmetụta mmekọrịta dị iche na Kaptopres site na ọgwụ ndị ọzọ nwere ngwa ọrụ yiri ya nke nwere captopril na-enweghị ihe ndị metụtara diuretic.

A na-etinye ọgwụ ndị dị ike n'ime ngwa nri (ihe ruru 30% nke ọgwụ a na-ejikọ ọnụ, a na-etinye ọnụ ọgụgụ ịta ahụhụ dịka nkeji 60 mgbe nchịkwa).

Oge iwepu ihe dị ka awa 3 (na ndị ọrịa nwere ọrụ imeju dị ezigbo ogologo - ogologo oge).

Ọgwụ na-emetụta njikọ nke ihe ndị na-akụda bradykinin

Olee ọrịa ndị a na-eji agwọ ọrịa?

Edere ọgwụ ahụ maka ọbara mgbali elu akwara, na-ahazi n'ụdị ndị a:

dị mkpa
symptomatic
ojoo
gbagwojuru anya site na mbuso agha angina,
Ahụ ike
renoparenchymal.

Na mgbakwunye, ndepụta nke akara maka nhọpụta nke "Kaptopres" gụnyere: ọbara mgbali elu, nephropathy nke ọrịa mamịrị, oke obi (na-enweghị ike ịbanye na glycosides cardiac), wdg.

Maka nsogbu ọgbụgba dị ala, a na-eji “Kaptopres” mee ka ihe mgbawa dị n'okirikiri ozugbo.

Jiri na ogwu na mgbochi

Kaptopres: ntụziaka maka iji megide nrụgide

Tupu ị takingụ ọgwụ ahụ maka ebumnuche ọgwụgwọ, ịkwesịrị iji nlezianya mụọ ntuziaka maka mbadamba mbadamba Kaptopres: n'oge nrụgide ị toụ mmanya, n'oge usoro onunu ogwu, wdg.

Kaptopres na-eme ka ọbara mgbali belata n'ụzọ dị mma site na ihe abụọ na-emetụta ahụ mmadụ n'ụzọ dịgasị iche.

Ọgwụ a na-arụsi ọrụ ike (n'ihi mmekọrịta nke ndị na - egbochi ACE na ihe ndị na - eme ka ihe na - arụ ọrụ), yabụ ịkwesịrị iji “Kaptopres” kpachara anya. Ọ bụrụ na nrụgide arịgoro ntakịrị, mgbe ahụ ị nwere ike ịme “Captopril” mbụ, “Kaptopres” kwesịrị maka nsogbu mgbagha ọbara mgbali elu, ma ọ bụ mgbe ndị na-egosi nrụgide gafere 180 kwa 100 mm RT. Art.

Optimally, ma ọ bụrụ na onunu ogwu nke ọgwụ a ga-ekpebi site ọkachamara. Ọtụtụ mgbe, dọkịta na-ede "Kaptopres", na-eburu n'uche ụdị ngosipụta ndị a:

ogo ọnọdụ onye ọrịa,
mkpa iji belata ọbara mgbali ngwa ngwa,
arụmọrụ akụrụ na imeju (ma ọ bụrụ na enwere ọrịa, a na-eji obere usoro onyonye).
ọnụnọ nke ọrịa concomitant na iji ọgwụ ndị ọzọ.

A na - ewere "Kaptopres" dị elu dị ka atụmatụ a si dị:

Mbadamba ị areụ mmanya dịkarịa ala otu awa tupu nri. Nke a na - egbochi iwepu ike mmiri nke ihe ndị na - arụ ọrụ.
A na-amalite iji usoro ọgwụgwọ mmezi ahụ site na iji ọkara mee ihe: 1 oge kwa ụbọchị, ọkara mbadamba ụrọ nwere otu usoro eji eme ihe.
Na enweghị ọgwụgwọ ọgwụgwọ, usoro onunu ogwu na-abawanye ka oge na-aga. N'okwu a, onye ọrịa na-a tabletụ mbadamba 1 kwa ụbọchị.
Iwere “Kaptopres” kacha mma n'otu oge. Erere mbadamba nkume ndị ahụ na-ata ata. Ikwesiri ị drinkụ ọtụtụ mmiri.

Ọ bụrụ na enyere iwu mbadamba ihe ọ theụ drinkụ otu ugboro n'ụbọchị, mgbe ahụ Kaptopres ka mma ịtụtụ n'ụtụtụ

A na-edenye ọgwụ ọgwụ na ọmụmụ, yana ogologo oge. Dabere na nyocha nke ndị dọkịta na ndị ọrịa na-ewere "Kaptopres", a na-ahụkarị ọgwụgwọ kachasị maka ọnwa 1.5-2 mgbe mmalite nke usoro ahụ.

Ọ bụrụ na ọ dị mkpa, a na-eme mgbanwe ndozi na oge nke ọnwa 1.5. Ewezuga ya bụ ọnọdụ mgbe akagbuola Kaptopres n'ihi ọtụtụ ebumnuche, ma ọ bụ ejiri ya na usoro ịba ụba iji kwụsị nsogbu ọbara ọgbụgba.

Mgbe ị na-eji "Kaptopres" na ọgwụgwọ ọbara ọgbụgba, ọ dị mkpa ị attentiona ntị na mgbochi afọ:

ejighị ọgwụ ahụ mee ihe iji belata nrụgide na ndị ọrịa na-erubeghị afọ 18,
Maka ndị ọrịa afọ 65 gbagoro, “Kaptopres” ka enyere iwu nke ukwuu, dabere na ntule ogo ọnọdụ ahụ.

Ọbara mgbali elu bụ ọbara mgbali elu mgbe niile nke na - ebute vasospasm na - eme ka mgbasa ọbara sie ike.

N'oge a, enwere ọtụtụ ihe na-emetụta mmepe nke ọbara mgbali elu, gụnyere mgbanwe metụtara afọ, arụ ọrụ anụ ahụ, nri na-adịghị edozi ahụ, mmebi nke nri nnu, ọnụnọ nke omume ọjọọ, nketa, ọrịa ndị ị nwetara na ọnụnọ nke oke ibu.

Ndị dọkịta na-ejikọta mmepe nke ọrịa a na mmebi nke ihe ndị dị na ya maka ịhazi arụmọrụ nke sistem obi. Ọzọkwa, isi ihe kpatara ọdịdị ọrịa a bụ ihe nketa.

Enwere otutu uzo iji luso oria a ọgụ, nke mbu n’ime ya bu ogwu eji eme aru. Otu n'ime ọgwụ ndị dị mma dị otú a bụ Kaptopres, analogues nke a ga-ahụ na ụlọ ahịa ọgwụ ọ bụla.

Captopres bụ ihe dị mgbagwoju anya na-ahụ maka ọgwụ ike, nke ihe mejupụtara ya bụ ihe abụọ na - arụ ọrụ - captopril na hydrochlorothiazide.

Ọgwụ a dị na mbadamba ụrọ, nke nwere ọrụ ezughị oke na ọrụ akwara. Mmetụta dị mma n'ahụ na ọgwụgwọ ahụ bụ n'ihi ọgwụ Njirimara nke ihe ndị bụ isi ji arụ ọrụ mejupụtara ihe mejupụtara ahụ.

Akụkụ nke mbụ akpọrọ captopril bụ ihe dị na otu nke angiotensin-na-agbanwe enzyme inhibitors. N'ihi nke a, ahụ nwere uru bara uru n'ihi mbelata ọbara mgbali elu na mbelata nguzogide vaskụla.

Akụkụ nke abụọ, nke a na-akpọ hydrochlorothiazide, bụ thiazide diuretic nke na-eme ka mkpochapu mmiri na sodium, chlorine na potassium na-arụ ọrụ. Withmekorita ya na ihe mbu ahu na - aru oru, na - eme ka ihe ya ghara idiwanye.

A na-atụ aro ị toụ ọgwụ ahụ ihe dị ka otu awa tupu nri, ebe ọ bụ na n'oge ya, a na-ebelata ihe ndị dị n'otu n'otu.

Ekwesịrị ịhọrọ usoro ọgwụgwọ kwesịrị ekwesị ọ bụ naanị dọkịta na-aga.

Imua nke mbu kwesiri ịmalite site na ọkara nke otu mbadamba otu ugboro kwa ụbọchị. Ọzọkwa, ekwesịrị ị theụ ọgwụ ahụ n'ụzọ a: usoro mmezi ahụ nwere ike ịbụ otu mbadamba otu ugboro n'ụbọchị.

Enwere ike mata mmetụta ọgwụgwọ kachasị akpọsa naanị ọnwa abụọ ka mmalite nke ị takingụ ọgwụ a. Ntụgharị nke usoro a dị ugbu a nwere ike ime naanị izu isii.

Kaptopres nwekwara contraindications, nke ekwesiri iburu n'uche:

ọrịa anakwere mere n'oge ọgwụgwọ n'etiti ndị na - egbochi ACE,
ịmụ nwa bụ angioedema,
Ngwurugwu ndi nwere ihe bara uru ion
nnu nke sodium na nnu mmiri,
gout
calcium ọbara dị elu
porfria
ime na lactation
oke nke aldosterone,
Nsogbu na akp ụkpa na arụ ọrụ nke akụkụ ahụ nke usoro excretory,
ikike okike
nnụnụ abụọ nwere akwara ma ọ bụ stenosis nke otu akụrụ na arịa azotemia na-aga n'ihu,
ọnọdụ siri ike mgbe ọ gbasesịrị akụrụ,
enweghi mmamiri na kaadi ime,
nsogbu ndị na - egbochi ọbara ịpụpụ site na ventricle ekpe,
mmetụta dị elu maka akụkụ nke ọgwụ ahụ, ọ kachasị ndị isi,
anabataghi nke ndị mejupụtara
oke imeju akwara mgbe enwere ọnọdụ precomatous ma ọ bụ ihe akpọrọ hepatic coma.

Ka ha na-a theụ ọgwụ ahụ, ndị ọrịa hụrụ ihe ndị a na-adịghị mma:

ọgbụgbọ
vomiting
mbelata nke ukwuu na agụụ,
mgbu mgbu
ọnụ kpọrọ nkụ
stomatitis
ọnyá afọ
jaundice
ịba ọcha n'anya
tachycardia na angina pectoris,
pallor nke anụ ahụ,
oke isi ọwụwa
urticaria
Ọrịa mgbakasị, karịsịa afọ ntachi na afọ ọsịsa,
n'ime ụmụ mmadụ, belatara agụụ mmekọahụ na enweghị ire ere,
aru di elu
haemoglobin dị ala
gbasara akwara.

Site n'iji ọgwụ a dịtụ ogologo oge dị ogologo oge, ndị ọrịa kwuru mmepe nke ihe ịtụnanya dị ka ọbara mgbali ala, tachycardia, isi ọwụwa, ọgbụgbọ, ọgbụgbọ, ugba na-adịghị mma na mbelata ahu ngwa ngwa.

Ọ bụrụ na eleghaara ọdịdị nke mgbaàmà na-adịghị mma anya, na onye ọrịa ahụ belatara ọgwụ ahụ, mgbe ahụ ọ nwere ike ịmalitepụta ngosipụta nke egbu egbu na hydrochlorothiazide.

A naghị ekwepị nsonaazụ ndị dị ka imebi nguzozi-nnu na mmakọ. Nke a bụ n'ihi na ọgwụ a nwere mmetụta siri ike na sistemụ ụjọ nke mmadụ.

N'ihe banyere ịdoụbiga mmanya ókè, onye ọrịa ahụ ga-agbari afo ahụ ozugbo ma nyekwa ya ọgwụ ndị eji eme ihe.

Ọ bụrụ na enwere mkpa, mgbe ahụ, ekwesịrị ịgwọ ọrịa pụrụ iche. Ọ bụrụ n ’nsị na-egbu egbu dị, mgbe ahụ ọ dị mkpa ịga ụlọ ọgwụ onye ahụ metụtara ngwa ngwa.

Usoro nke usoro enyemaka mbụ nye onye ọrịa na-agụnye ọgwụgwọ metụtara hemodial ozugbo. Na mgbakwunye na ya, ọ dị mkpa ịnye usoro ga-enyere aka weghachite ma dozie nguzo mmiri-electrolyte.

Ndị na - egbochi ndị ọzọ na Akkupro

Acupro na contraindicated n'ime ụmụaka na ndị nọ n'afọ iri na asatọ, ndị ọrịa nwere akụkọ banyere ọrịa angioedema, nke ejikọtara ya na ọgwụgwọ ACE inhibitor, yana inwekwu mmụọ ndidi banyere akụkụ ọ bụla nke ọgwụ.

N'iji nlezianya, edere Akkupro ma ọ bụrụ na enwere akụkọ banyere angioedema ma ọ bụrụ na ọ nweghị ihe jikọrọ ya na ndị na-egbochi ACE, na nnukwu nkụchi obi na nnukwu ihe mgbapụta, yana hyperkalemia, mbelata nke BCC, aortic stenosis, ọnọdụ mgbe akụrụ akụrụ, mgbochi nke ụmị ọkpụkpụ. ọrịa autoimmune nke anụ ahụ jikọrọ ọnụ, ọrịa shuga mellitus, imeju na-arịa ma ọ bụ ọrụ akụrụ na oke ịwa ahụ.

Usoro onunu ogwu na nchịkwa Akkupro

N'ime ọgwụgwọ ọbara mgbali elu, a na-enye ndị ọrịa na-anata akaghị aka ọgwụ 10 ma ọ bụ 20 mg nke ọgwụ otu ugboro n'ụbọchị. Enwere ike ịbawanye dose ahụ dabere na nsonaazụ ụlọ ọgwụ. Ulo mmezi bu 20 ma obu 40 mg kwa ubochi, dika esi edo ya n’otu uzo ma obu abuo. Ọgwụ dịgasị iche na oge nke izu anọ. N'ọnọdụ ka ukwuu, enwere ike ịnweta njikwa ọbara zuru oke n'oge ọgwụgwọ ogologo oge site na itinye Accupro oge 1 kwa ụbọchị. Ogo ị na-anabata kwa ụbọchị bụ 80 mg.

Ndị ọrịa na-anọgide na-a diụ ọgwụ ọrịa na-ebu ụzọ depụta ọgwụ ọgwụ 5 mg nke ọgwụ, emesịa ịbawanye dose ahụ ruo mgbe a ga-enweta nsonaazụ kachasị mma.

Ejiri ojiji nke Accupro na ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala dịka akụkụ nke usoro ọgwụgwọ dị mgbagwoju anya na diuretics na / ma ọ bụ cardiac glycosides. N'okwu a, ọgwụ mbụ bụ 5 mg 1 ma ọ bụ ugboro abụọ kwa ụbọchị. Ọ bụrụ na-anabata ọgwụ ahụ nke ọma, enwere ike ịbawanye dose ahụ ruo 10-40 mg kwa ụbọchị na usoro 2 hà.

A na-atụ aro ịmalite usoro ọgwụgwọ Akkupro na ndị ọrịa na-arịa ọrụ ezumike nsogbu na 5 mg nke ọgwụ otu ugboro n'ụbọchị. N'echi ya, ọ bụrụ na ịnabata ọgwụ izizi ahụ dị mma, a pụrụ inye ọgwụ mgbochi abụọ n'otu ụbọchị. Na enweghị ọrụ ezigharị arụ ọrụ ma ọ bụ hypotension, enwere ike ịbawanye dose ahụ kwa izu.

N'ime ndị ọrịa agadi, usoro akwadoro ịmalite bụ 10 mg otu ugboro n'ụbọchị. Nke ọzọ, enwere ike ịba ụba iji nweta oke ọgwụgwọ kachasị mma.

Ntụziaka pụrụ iche

Achọpụtara na n'oge ọgwụgwọ na ndị na - egbochi ACE, angioedema ga - ekwe omume (0.1% nke ikpe). Ọ bụrụ na angioedema nke ire, ihu, ma ọ bụ epiglottis pụtara, a ga-akwụsị ọgwụgwọ Acupro ozugbo. Ekwesịrị ịnye onye ọrịa ahụ ọgwụ kwesịrị ekwesị ma lelee ya ruo mgbe edem ahụ kwụsịrị. Egbugbere ọnụ ọnụ na ihu ihu n'ọtụtụ oge na - apụ na enweghị ọgwụgwọ pụrụ iche, mana enwere ike iji ọgwụ mgbochi iji belata ihe mgbaàmà. Udere nke Laryngeal nwere ike igbu egbu. Ọ bụrụ na enwere ihe mgbochi nke ụzọ ikuku, a chọrọ ọgwụgwọ mberede, gụnyere iwebata adrenaline na usoro ndị ọzọ.

Site na iji ọgwụ ahụ, angioedema nke eriri afọ nwere ike ịmalite, nke afọ na-egosipụta site na mgbu na-enweghị ọgbụgbọ na ọgbụgbọ. Mgbaàmà kpamkpam n'anya mgbe ịkwụsị ACE inhibitors.

Ndị ọrịa na-anata ihe mgbochi ACE n'oge ọgwụgwọ na Hymenophera venom nwere ike ịmalite mmeghachi mmekpa ahụ na-eyi ndụ egwu.N'ime ndị ọrịa na-a diụ ọgwụ mkparị, nchịkwa nke Accupro nwere ike ibute ọgbụgba hypotension Symptomatic arterial hypotension. Ọ bụrụ na onye ọrịa chọrọ ọgwụgwọ ọrịa diuretic, a ga-akwụsị ya ụbọchị 2-3 tupu ịmalite Acupro.

N'ime ndị ọrịa nwere ọbara mgbali elu nke nwere akwara ma ọ bụ nke nwere akwara ụkwụ abụọ, ọgwụgwọ na Accupro nwere ike ibute mmụba na serin creatinine na urea nitrogen n'ime ọbara. Mgbanwe ndị dị otú a na-apụ n'anya mgbe ịkwụsị ọgwụ. N'okwu a, a ga-enyocha ọrụ akụrụ n'ime izu ole izizi ọgwụgwọ.