Ọgwụ Plevilox: ntuziaka maka ojiji

5 pcs. - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (2) - ngwugwu nke kaadiboodu.
100 pcs - akpa rọba (1) - Mkpọ polymer.
1000 PC - akpa rọba (1) - Mkpọ polymer.
500 PC - akpa rọba (1) - Mkpọ polymer.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.
7 pcs - blisters (1) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Onye na-ahụ maka ọgwụ mgbochi site na otu fluoroquinolones, na-eme nje. Ọ na - arụ ọrụ na - emegide micromgangan gram na-adịghị mma na gram na - adịghị mma, anaerobic, acid na - eguzogide ọgwụ na atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Ọ dị irè megide ụdị nje na-eguzogide ọgwụ beta-lactams na macrolides. Ọ na - arụ ọrụ megide ọtụtụ ụdị microorganisms: gram-nke oma - Staphylococcus aureus (gụnyere ụdị adịghị emetụta methicillin), pulcoeptoptoccccus (gụnyere nje ndị na - eguzogide penisilini na macrolides), Streptococcus pyogenes (otu A), gram-negative - Haemophilus influenzae ( na nje ndị na-abụghị beta-lactamase), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (gụnyere ma ndị na-anaghị emepụta beta na-abụghị beta-lactamase), Escherichia coli, Enterobacter cloacae, Chlamydia na oyi baa. Dika ihe omumu banyere vitro siri di, obu ezie na umu ihe ndi ahuru n’okpuru ebe a bu ihe banyere moxifloxacin, agbanyeghi, o dobeghi nchekwa ya na odi nma n’imeso oria. Gram-mma ntule: streptococcus milleri, streptococcus mitior, streptococcus agalactiae, streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (gụnyere nje, methicillin mwute), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Mkpụrụ ndụ na-adịghị mma: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter nkezaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. A na-ahụkarị microorganisms: Legionella pneumophila, Caxiella burnettii.

Nkanka topoisomerases nke II na nke anọ, enzymes na-achịkwa njirimara topological nke DNA, ma na-etinye aka na nnomi, ndozi, na ntụgharị DNA. Mmetụta nke moxifloxacin na-adabere na ntinye uche ya na ọbara na anụ ahụ. Obere ihe ncheta nke nje bacteria na-adịghị iche na nke kacha nta nke inhibitory.

Developmentzọ mmepe nrụgide, inactivating penicillins, cephalosporins, aminoglycosides, macrolides na tetracyclines, anaghị emetụta ọrụ antibacterial nke moxifloxacin. Enweghị nguzogide n'etiti moxifloxacin na ọgwụ ndị a. Achọpụtaghị usoro mmepe mbido plasmid. Ọnọdụ nguzogide n'ozuzu ya dị ala. Na nyocha nke vitro egosiwo na iguzogide moxifloxacin na-amalite nwayọ nwayọ n'ihi nsonye na-agbanwe oge. Site na ikpughe microorganisms ugboro ugboro na moxifloxacin na subminimal inhibitory concentrations, ihe ngosi BMD na-abawanye ntakịrị. A na-ahụta nguzogide nkwụghachi n'etiti ọgwụ ọjọọ sitere na otu fluoroquinolone. Agbanyeghị, ụfọdụ microorganisms gram-positive na anaerobic na-eguzogide fluoroquinolones ndị ọzọ na-emetụta moxifloxacin.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-etinye moxifloxacin ngwa ngwa ma ọ fọdụ nke ọma. Mgbe otu ọgwụ moxifloxacin na-a atụ n’arọ nke ọ̀tụ̀tụ̀ 400 mg C max n’ọbara na-enweta n’ime awa 0,5-4 ọ bụrụ 3.1 mg / L

Mgbe otu mkpụrụ ọgwụ na ọkara nke mg mg maka 1 h, a na-enweta C max na njedebe nke infusion ya bụ 4.1 mg / l, nke kwekọrọ na mmụba nke ihe dị ka 26% ma e jiri ya gosipụta uru a na-egosi mgbe a na-ekwu ya. N'ihe banyere otutu infusus IV na ọgwụ nke 400 mg maka elekere 1, C max dịgasị na oke site na 4.1 mg / l ruo 5.9 mg / l. Nkezi C ss nke 4,4 mg / L ruru na njedebe nke ọgbụgba ahụ.

Ezigbo bioavailability dị ihe dịka 91%.

The pharmacokinetics nke moxifloxacin mgbe ewere ya na otu onunu si 50 mg ruo 1200 mg, yana na 600 mg / ụbọchị maka ụbọchị 10, bụ ahịrị.

Ekwadoro steeti etolite n’ime ụbọchị 3.

Indtinye aka na-edozi ọbara (ọkachasị albumin) bụ ihe dịka 45%.

A na - ekesa Moxifloxacin ngwa ngwa n’akwara na akwara. V d bụ ​​ihe dịka 2 l / n'arọ.

Nnukwu uche nke moxifloxacin, karịa ndị nọ na plasma, ka etinyere n’akwara umeji (gụnyere alveolar macrophages), na akpụkpọ ahụ mucous nke bronchi, na sinuses, na anụ ahụ dị nro, akpụkpọ ahụ na akụkụ ya, nke na-efe efe. N'ime mmiri interstitial na mmiri, ọgwụ ahụ na-ekpebisi ike n'ụdị na-abụghị protein, na mkpo dị elu karịa na plasma. Na mgbakwunye, a na-ekpebi nnukwu ihe nke arụ ọrụ n'ime akwara afọ na mmiri ọnya ọgbụgba, yana akwara nke akụkụ ahụ nwanyị.

Biotransformes ka mmiri sulfo na glucuronides na-adịghị arụ ọrụ. Moxifloxacin abụghị biotransformziki nke microsomal enzymes nke sistemụ cytochrome P450.

Mgbe ọ gafesịrị usoro nke biotransformation nke abụọ, moxifloxacin na-apụta site n'ahụ mmadụ site na akụrụ na site na eriri afọ, ma agbanweghi ya na ụdị sulfo na-arụ ọrụ na glucuronides.

A na-etisa ya na mmamịrị, yana yana feces, ma na-agbanweghi agbanwe ma n’ụdị metabolites na-adịghị arụ ọrụ. N'iji otu nari 400 mg, ihe dị ka pacenti iri asaa na asaa apụtaghị na mmamịrị ahụ, ihe dị ka 25% na feces. T 1/2 dị ihe dị ka awa 12. Oge ngụkọta nhichapụ mgbe nchịkwa na ọnụọgụ 400 mg bụ site na 179 ml / min ruo 246 ml / min.

Ihe ngosi maka ojiji

Ọrịa nke akụkụ elu na nke iku ume: nnukwu sinusitis, njọ nke bronchitis na-adịghị ala ala, oyi ịba n'aka obodo, ọrịa nke anụ ahụ na anụ ahụ dị nro, ọrịa metụtara intra-ciki, gụnyere bu oria a na-ebute site na otutu oria, oria na - agha oria n’azu oke.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime ma ọ bụ n’ụdị nke infusion ọbara (jiri nwayọ, karịa nkeji 60) - 400 mg 1 oge kwa ụbọchị. Erere mbadamba ihe nile, na nri adighi, n'agbanyeghị nri. Treatmentzọ ọ ga-esi gwọọ ọrịa bronchitis na-adịghị ala - ụbọchị 5, oyi ịba n’obodo - ụbọchi sinusitis na-efe efe, ọnya anụ ahụ na anụ ahụ dị nro - ụbọchị 7, nwere nsogbu ọnya ọgbụgba dị n’ime - n’ime ụbọchị 5-14 (iv ya na nke na-esote nyefe na nchịkwa ọnụ) , ọrịa na - adịghị ala ala nke akụkụ ahụ pelvic - 14 ụbọchị.

Ọ dịghị mkpa ịgbanwe usoro onunu ogwu na ndị agadi nwere ọrịa ịba ọcha n'anya (otu A, B n'ihe banyere -mụaka-Pugh) na / ma ọ bụ renal (gụnyere CC na-erughị 30 ml / min / 1.73 sq.m).

Nsonaazụ

Ọtụtụ mgbe - 1-10%, adịkarịghị - 0.1-1%, ọ dị ụkọ - 0.01-0.1%.

Site na usoro digestive: oge ​​- mgbu afọ, dyspepsia (gụnyere flatulence, ọgbụgbọ, ọgbụgbọ, afọ ntachi, afọ ọsịsa), ụba ọrụ nke transminases "imeju", adịkarịghị - akọrọ mucous akpụkpọ ahụ nke oghere ọnya, candidiasis nke onu mucosa, anorexia, stomatitis, glossitis, gamma-glutamintransferase mụbara, adịkarịsịrị - gastritis, ịkpụcha ire, dysphagia, jaundice trensient.

Site n'akụkụ akụkụ akwara: mgbe mgbe - ọgbụgba, isi ọwụwa, adịkarịghị - asthenia, nsogbu ehighị ụra ma ọ bụ ụra, ụjọ ahụ, ụjọ, ịma jijiji, paresthesias, adịkarịghị - hallucinations, depersonalization, tone muscle olu, nsogbu ịhazi, mmegharị, mmegharị, amnesia, aphasia, nnuku mmetụta uche, nchekasị ihi ụra, ọgba aghara okwu, enweghị ọgụgụ isi, hypesthesia, nkwarụ, ọgba aghara, ịda mba.

N’akụkụ akụkụ anụ ahụ nke anụ ahụ: mgbe mgbe - mgbanwe n’inwe uto, ọ na-esiri ike - enweghi ike ịhụ ụzọ, amblyopia, ọnwụ nke mmetụta uto, parosmia.

Site na CCC: adịkarịghị - tachycardia, ọbara mgbali elu, palpitations, mgbu obi, ịgbatị oge nke Q-T, adịkarịghị - belata ọbara mgbali, vasodilation,

Site na sistem iku ume: adịkarịghị - mkpụmkpụ ume, ọ na - adịkarịke - ụkwara ume ọkụ.

Site na usoro akwara: arthralgia, myalgia, nke a na - adịghị ahụkebe - mgbu azụ, mgbu ụkwụ, ogbu na nkwonkwo, tendopathy.

Site na usoro mkpụrụ ndụ: adịkarịghị - candidiasis, vaginitis, nke adịkarịsịrị - mgbu na mpaghara ala, ọzịza nke ihu, akụkụ akụkụ, ọrụ na-arụ ọrụ na-arụ ọrụ nke ọma.

Mmeghachi omume nfụkasị ahụ: ọ na - adịkarịghị - ihe ọkụ ọkụ, itching, oke adịkarịghị - urticaria, ujo ụjọ.

Mmeghachi omume mpaghara: ọtụtụ mgbe - edema, mbufụt, ihe mgbu na ntinye ahụ, ọ na - adịkarịghị - phlebitis.

Ihe ngosi nke ulo-akwukwo: adighi ike - leukopenia, mmụba na oge prothrombin, eosinophilia, thrombocytosis, mmụba na amylase, adịkarịghị - mbelata nke mkpokọta thromboplastin, mbelata oge prothrombin, thrombocytopenia, anaemia, hyperglycemia, hyperlipidemia, ọrịa na-arịwanye elu, na-arịwanye elu na-arụ ọrụ, ọbara na-arịwanye elu, na-arịwanye elu na arụ ọrụ, ọbara na-arịwanye elu, na-arịwanye elu na arụ ọrụ, ọbara ọgbụgba. Egosipụtaghi njikọ dị n'etiti nchịkwa ọgwụ ahụ: mmụba ma ọ bụ mbelata na hematocrit, leukocytosis, erythrocytosis ma ọ bụ erythropenia, mbelata nke mkpokọta glucose, Hb, urea, mmụba nke ọrụ alkaline phosphatase.

Ndị ọzọ: adịkarịghị - candidiasis, ahụ erughị ala, sweating.

Ntụziaka pụrụ iche

N'oge ọgwụgwọ na fluoroquinolones, mbufụt na mgbaze nke akaị nwere ike ịmalite, ọkachasị ndị ọrịa agadi na ndị ọrịa na-anata corticosteroids n'otu oge. Na ihe ịrịba ama mbụ nke mgbu ma ọ bụ mbufụt nke akwara, ndị ọrịa kwesịrị ịkwụsị ọgwụgwọ ma mee ka aka ahụ emetụtara.

Enwere mmekọrịta dị n'etiti mmụba nke mkpokọ moxifloxacin na mmụba na oge Q-T (ihe egwu nke ịmalite nsogbu ventricular arrhythmias, gụnyere torsades de pointes). N'ihi nke a, ọgwụ a tụrụ aro (400 mg) ekwesịghị ịfefe na infusion kwesịrị imecha (opekata mpe 60).

N'ihe banyere oke ọgbụgba n'oge ọgwụgwọ, ekwesịrị ịkwụsị ọgwụ a.

Mmekorita

Antacids, mineral, multivitamins na-eme ka ihe ghara ịdị n’onwe ha (n’ihi ịka nke chelate ogige nwere polyvalent cations) ma belata ịta moxifloxacin na plasma (nchịkwa n’otu oge ga-ekwe omume n’agbata awa anọ tupu ma ọ bụ elekere 2 mgbe ị nwesịrị moxifloxacin).

Ojiji a na-ejikọ ya na quinolones ndị ọzọ na-eme ka ohere nke ịgbatị oge Q-T dị.

Nke nta na-emetụta ọgwụ ọgwụ nke digoxin.

GCS na-abawanye n'ihe ize ndụ nke tendovaginitis ma ọ bụ mgbaji akwara.

Ngwakọta infusion dabara na usoro ọgwụ ndị a: 0.9% na 1 ihe ngosi NaCl molar, mmiri maka ntụtụ, ngwọta dextrose (5, 10 na 40%), 20% xylitol, ihe mgbapụta Ringer, Ringer-lactate, 10% Aminofusin ngwọta, ngwọta Yonosteril.

Emeghere nke 10 na 20% NaCl ngwọta, 4.2 na 8.4% Na bicarbonate ngwọta.

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe ntọhapụ nke ọgwụ ahụ bụ mbadamba ihe mkpuchi. Mbadamba nke ọ bụla nwere 436.4 mg nke moxifloxacin hydrochloride, nke kwekọrọ 400 mg moxifloxacin. Ihe ndi pere mpe:

• iron oxide uhie dye,
• hydroxypropyl methylcellulose,
• stereta magnesium,
• MCC
• sodium croscarmellose,
• lactose monohydrate.

Etinye ọgwụ ahụ n’ime blisters nke 5, 7 ma ọ bụ 10 PC. ma ọ bụ na karama polymer nke 100, 500 ma ọ bụ 1000 PC. (maka ụlọ ọrụ ọgwụ). Igbe ahụ nwere ike ịnweta blister 1, 2 ma ọ bụ karama polymer 1.

Mlọ ọgwụ

Ọgwụ bụ ọgwụ nje fluoroquinolone ma nwee mmetụta nje.

Gram-ọjọọ aerobic microorganisms nwere ogo dị iche nke uche maka ihe ọgwụ ahụ.

Akụkụ ya nọ n'ọrụ na-emetụta ntụgharị nke DNA nke microorganisms na-emerụ ahụ, si otú a na-atụnye ụtụ maka ọnwụ ha ngwa ngwa. Aerobes dị mma na-eme ka ọnụnọ ya dị mma na-emetụta ya: Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus mitis, staphylococcus saprophyticus, Streptococcus agalactiae, staphylococcus hominis, Haemophilias parainfluenzae, Enterobacter cloae.

Microorganisms nke aerobic na-enwe mmetụta dị iche iche maka mmetụta nke ọgwụ a: Porphyromonas asaccharolyticus, Bacteroides ovatus, Porphyromonas asaccharolyticus, Prevotella spp., Mycoplasma pneumonia, Coxiella bumettii.

Mmetụta uche na-erughị eru nke ọgwụ nje bụ: Stenotrophomonas maltophilia, Burkholdera cepacia, Pseudomonas aeruginosa.

Edere ikpe nke nguzogide ọgwụ ndị ọzọ sitere na otu nke fluoroquinolones.

Ihe ngbanwe

Ntụziaka a machibidoro idepụta ọgwụ n'ihe ndị dị otú a:

• ọrịa shuga mellitus
• Akwụkwụ na-adọ
• nnukwu afọ ọsịsa
• n'okpuru afọ 18
• hypokalemia a na-achịkwaghị achịkwa,
• lactation
• tụụrụ ime

Ekwesịrị ịkpachara anya banyere ọgwụ nje na-arịa ọrịa hepatic, hypokalemia, ọrịa nkwarụ, ogologo oge QT, pseudomembranous colitis, yana corticosteroids. Na mgbakwunye, a ga-eji ọgwụ kpachara anya banyere ndị ọrịa na-arịa ụdị ọrịa a.

Dodoụbiga ya ókè

Onye ọrịa nwere ike ịnwe nkwarụ, ịma jijiji, afọ ọsịsa, vom, na ura mgbe ọ na - eji ọgwụ nje karịrị oke.

Usoro ọgwụgwọ ahụ gụnyere nsacha bowel na iji ọgwụ ndị na-anabata ihe.

Usoro ndị ọzọ bụ usoro Symptomatic ma kwesiri ka arụ ya n'okpuru nlekọta nke onye egosi ECG. Ngwọta ọgwụ nke ihe ahụ adịghị.

Mkparịta ụka ọgwụ ọjọọ

Mgbe ejikọtara ya na ọgwụ, mineral, antacids, multivitamins ga-eme ka mmụba ya belata belata ịta plasma.

Ojiji nke ọgwụ nje na quinolones ndị ọzọ na-eduga n'ọdịdị nke ngosipụta fototoxic.

Ranitidine na-ebelata mwepu moxifloxacin.

Ọnụahịa dị na ahịa ọgwụ

Ọnụ ego ọgwụ nje na-amalite site na 620 rubles. maka mbadamba 5 na mkpọ.

Ọ bụrụ na enwere ọgwụ mgbochi ọgwụ ma ọ bụ na ọnụnọ ya na ahịa ọgwụ n'oge ịzụta, ịnwere ike inye mmasị nke otu ọgwụ ndị a:

• Maxiflox
• Alvelon-MF,
• Akwukwo
• Akara,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Mgbaji moxifloxacin,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), obodo Balakovo

Ọgwụ nke anọ na-eji ọgwụ nje fluoroquinolone eme ihe. Nsonaazụ ahụ fọrọ nke nta ka o buru amụma 100%. Mmetụta ọghọm dị ole na ole Edere m ya maka usoro ọgwụgwọ siri ike nke urethritis na prostatitis.

Tatyana Sidorova, 38 afọ, obodo Dzerzhinsk

Site n'enyemaka nke ọgwụ nje a, a gbakere nke mycoplasmosis. Usoro akara usoro dị mma - oge 1 kwa ụbọchị, enweghị nlọghachi ọzọ nke ọrịa yana ihe ịrịba ama ọ bụla. Emezuru mmetụta a n'ime ụbọchị 8-9 nke ị theụ ọgwụ.

Kristina Verina, afọ 25, obodo Zelenogorsk

N’ụlọ ọgwụ, a chọpụtara na m nwere ọrịa nje oyi ịba, na mgbe nke ahụ gasịrị, ha tinyere m n’ụlọ ọgwụ ụbọchị iri. Mgbe ebugharị ya na ọgwụ gbasara ọgwụ, ana ede ọgwụ a yana doxycycline. Ahụghị m mmetụta ọ bụla na-egosi na ntuziaka ahụ, enweghị mgbakasị ahụ n'oge ị ofụ ọgwụ niile. Ugbu a, agbakeela m, obi adị m mma.

Vera Ignatyeva, onye gbara afọ 34, bụ obodo Kalach-on-Don

Mgbe m hụrụ cystitis, amalitere m iji Aquamox, mana enwere m nfụkasị ya. Dọkịta ji plevilox dochie ya. Ahụ m were ọgwụ a. E wepụrụ ọrịa ahụ n'ime izu 1.5 nke nchịkwa ọgwụ mgbe niile na usoro ọgwụgwọ egosipụtara.

Ime na lactation

Emebebeghị nchekwa nke moxifloxacin n'oge afọ ime.

A kọwawo mmerụ ahụ nkwonkwo ahụ ụmụaka na-emeso ụfọdụ ọgwụ mgbochi quinolone, mana a kọpụtabeghị mmetụta yiri nke ahụ kpughere nwa ebu n’afọ. Ihe omumu banyere anumanu gosiri ihe banyere omumu.

Iji moxifloxacin n'oge ime bụ nke contraindicated.

Dị ka ọgwụ nje quinolone ndị ọzọ, moxifloxacin nwere mmetụta na-emerụ ahụ na mmepe na uto nke anụ ahụ na-akwado nkwonkwo na-akwado ụmụ anụmanụ.

Obere ego nke moxifloxacin na-apụ apụ na mmiri ara. Enwere ike inweta data maka iji moxifloxacin na ụmụ nwanyị n'oge a na-enye ara na nri.

Iji ọgwụ moxifloxacin na ụmụ nwanyị nọọsụ na-egbochi ndị ọzọ.

Data Nchekwa nke ime

Na nyocha nke nnabata na nkịta, enweghị akara nke anabataghị ihe mgbe ị na-eji moxifloxacin intravenously. Mgbe nchịkwa intraarterial, a hụrụ mgbanwe mkpali metụtara anụ ahụ dị mkpụmkpụ, nke na-egosi na a ga-ezere intraarterial management nke moxifloxacin.

Usoro onunu ogwu na nhazi

Ndị okenye

Dose nke Plevilox 400 mg (1 mbadamba) otu ugboro kwa awa 24. Ogologo oge ọgwụgwọ ahụ na-adabere n'ụdị ọrịa ahụ, dịka akọwara ya na tebụl 1.

Tebụl 1: Usoro ugwọ na oge ọgwụgwọ na ndị ọrịa okenye

Dose kwa awa 24

Ogologo oge b (ụbọchị)

Ọrịa jisiri na-akpata nnukwu ọrịa

Ahụhụ na-adịghị ala ala nke akwara ozi ala ala

Ọrịa a na-ahụkarị na akpụkpọ ya na akụkụ ya

Ọrịa bute ọnyá anụ ahụ na akụkụ ya

Ọrịa intraabdominal na-efe efe

ihe kpatara nsogbu a (lee mpaghara “Ihe ngosi maka iji”).

6 Enwere ike ịkọwa usoro ọgwụgwọ (n'esepụghị ọnụ na ọnụ) na nyocha nke dọkịta.

A na-egosipụta nchịkwa ọgbụgba mgbe ụzọ nlekọta a kacha dị mma maka onye ọrịa (dịka ọmụmaatụ, onye ọrịa agaghị enwe ike iji usoro onunu ogwu). Mgbe ị na-agbanwe site na nchịkwa intravenous gaa na nchịkwa ọnụ, ọ dịghị mkpa ịgbanwe ndozi ọgwụ. Enwere ike ibunye ndị ọrịa ọrịa ọgwụ malitere site na nchịkwa akwara nke moxifloxacin na mbadamba ụrọ dabere n'ihe ngosipụta ụlọ ọgwụ na arụmọrụ nke dọkịta.

Onu ogugu ndi puru iche

N'ime ndị agadi na ndị ọrịa nwere ahụ ha dị obere, a naghị achọ ndozi dose.

Moxifloxacin bu contraindicated na umuaka na umuaka

Njirimara ngwa

Nsi mmụpụta

Mgbe ị na-amụ mmetụta nke moxifloxacin na ọrụ omumu na oke, oke bekee na enwe, e gosipụtara na moxifloxacin gafere Plasenta. Mmụta na oke (mgbe ị na-ekwu okwu iji moxifloxacin na intravenously) na enwe (mgbe ị na-eji moxifloxacin n'ime) ekpughere mmetụta teratogenic nke moxifloxacin na nsonaazụ ya na ọmụmụ. Site na iji moxifloxacin na intraven na oke bekee nke 20 mg / kg, a hụrụ mmejọ nke ọkpụkpụ ahụ. Ndị a data tụnyere mmetụta amaara nke quinolones na mmepe skeletal. E gosipụtara mmụba nke ọtụtụ ịkpa ime na ụmụ oke na oke bekee site n'iji moxifloxacin na usoro ọgwụgwọ. Na oke, enwere mbelata nke ibu nwa ebu n'afọ, mmụba ime ime, ntakịrị mmụba na oge ọmụmụ ga-abawanye na mmụba nke mkpụrụ nke nwoke na nwoke mgbe ị na - eji moxifloxacin, usoro onodu ogwu a ji okpukpu iri isii karịa nke ọgwụgwọ mmadụ tụrụ aro maka ya.

Mmetụta ikike ịkwọ ụgbọ ala na ndị ọzọ nwere ike ịdị ize ndụusoro

Fluoroquinolones, gụnyere moxifloxacin, nwere ike iduga ike isi n'ịkwọ ụgbọala ma ọ bụ usoro ndị ọzọ nwere ike ibute nsogbu n'ihi mmeghachi nke sistemụ akwara etiti.

Nchedo nchekwa

N'ọnọdụ ụfọdụ, mgbe ị firstụsịrị ọgwụ mbụ, ịba ọcha na mmeghachi omume nfụkasị nwere ike ịmalite. Ọ dịkarịghị ala, mmeghachi omume anaphylactic nwere ike ịga n'ihu na ihe atụ nke ndụ anaphylactic, ọbụlagodi mgbe ị firstụ ọgwụ mbụ. N'ụdị ndị a, ekwesịrị ịkwụsị moxifloxacin yana usoro ọgwụgwọ dị mkpa (gụnyere mgbochi ụjọ).

A kọọla banyere ọrịa ịba ọcha n'anya zuru oke, nwere ike ibute ọrịa imeju na-egbu ndụ, gụnyere ọnwụ. Ọ bụrụ na ihe ịrịba ama nke imeju apụta, ndị ọrịa kwesịrị ịkpọtụrụ dọkịta ozugbo tupu ha agawa ọgwụgwọ.

Ọ bụrụ na mmeghachi ahụ na-apụta n'akụkụ anụ ahụ na / ma ọ bụ akpụkpọ ahụ mucous, ị kwesịrị ịkpọtụrụ dọkịta ozugbo tupu ị gaa n'ihu ọgwụgwọ. Ojiji nke quinolone ogwu jikọtara ya na ihe nwere ike ime nke nwere ike ime ndu. A ga-eji Moxifloxacin kpachara anya na ndị ọrịa nwere ọrịa akwara ozi etiti yana ọnọdụ nke na-enyo enyo na usoro ụjọ akwara dị n'etiti, na-ekwupụta oge ihe ọdịdọ na-eme, ma ọ bụ wedata mbido ọnụ maka mmekpa ahụ.

Ojiji nke ọgwụ nje oke ọgụ, gụnyere moxifloxacin, nwere ihe ọghọm nke ịmalite ịrịa ọrịa pịudomembranous metụtara ị takingụ ọgwụ nje. Ekwesịrị iburu nchoputa a n'uche ndị ọrịa na-enwe oke afọ ọsịsa n'oge ọgwụgwọ moxifloxacin. N'okwu a, ekwesịrị ịgwọ ọgwụ kwesịrị ekwesị ozugbo. A na-egbochi ndị ọrịa nwere nnukwu afọ ọsịsa na ọgwụ mgbochi ndị na-egbochi motility eriri afọ.

Ekwesịrị iji Moxifloxacin jiri nlezianya mee ihe na ndị ọrịa nwere Gravis myasthenia gravis, ebe ọ bụ na ọgwụ ahụ nwere ike iwepụ ihe mgbaàmà nke ọrịa a. N'oge ọgwụgwọ fluoroquinolones, gụnyere moxifloxacin, ọkachasị na ndị ọrịa agadi na-anara glucocorticosteroids, akwara na nkwonkwo akwara nwere ike ịmalite. Na ngosipụta mbụ nke ihe mgbu ma ọ bụ ọnya na saịtị mmerụ ahụ, ekwesịrị ịkwụsị ọgwụ ahụ ma belata aka na aka ahụ.

Maka ndị ọrịa nwere ọrịa mbufụt nke akụkụ ahụ nke pelvic (dịka ọmụmaatụ, ejikọtara ya na tubo-ovarian ma ọ bụ ọrịa pelvic) maka onye a na-egosi ọgwụgwọ ọgbụgba, a na-atụ aro iji moxifloxacin na mbadamba 400 mg.

Mgbe ị na-eji quinolones, a na-achọpụta mmeghachi omume fotoensitivity. Agbanyeghị, n'oge usoro ọmụmụ, nyocha ụlọ ọgwụ, yana iji moxifloxacin na omume, enweghị nchọpụta mmeghachi omume. Agbanyeghị, ndị ọrịa na-anata moxifloxacin kwesịrị izere ìhè anyanwụ na ultraviolet radieshon kpọmkwem.

Mgbakwunye nkejiQTcna ike metụtara ọnọdụ ọrịa

Achọpụtara na moxifloxacin gbatịkwuru oge QTc na electrocardiogram nke ụfọdụ ndị ọrịa. N'oge nyocha nke ECG nwetara dịka akụkụ nke mmemme nyocha ụlọ ọgwụ, ịgbatị oge nke QTc oge na-ewere moxifloxacin bụ 6 milliseconds ± 26 milliseconds, nke bụ 1.4% ma e jiri ya tụnyere ọkwa mbụ. N'ihi eziokwu ahụ bụ na ogologo oge mbụ nke oge QTc na ụmụ nwanyị dị ogologo karịa na ụmụ nwoke, ụmụ nwanyị nwere ike ịbụ ndị kachasị nwee ike ịme ihe ọgwụ ga-agbatị QTc. Agadi ndi okenye karie aru ogwu nke ogwu QT.

Ogo ịgbatị oge nke oge QT nwere ike ịbawanye elu site na ị ofụ ọgwụ ọfụma, yabụ ogo a tụrụ aro agaghị agafe. Associatedgbatị oge nke QT na-esonye n'ihe egwu dịwanye elu nke arrhythmias, gụnyere polymorphic ventricular tachycardia. Agbanyeghị, na ndị ọrịa nwere oyi baa enweghị njikọ n'etiti ịta moxifloxacin na plasma ọbara na ịgbatị nke etiti QT. Onweghị onye n'ime ndị ọrịa 9,000 e mesoro moxifloxacin nwere nsogbu obi na ọnwụ nke metụtara ogologo oge QT. Agbanyeghị, na ndị ọrịa nwere ọnọdụ na-ekwu maka arrhythmias, iji moxifloxacin nwere ike ịbawanye ohere nke ventricular arrhythmias.

N'akụkụ a, a ga-ezere nchịkwa nke moxifloxacin na ndị ọrịa nwere ogologo oge QT, hypokalemia na-adịghị edozi, yana ndị na-anata klas antiarrhythmic ọgwụ (quinidine, procainamide) ma ọ bụ klas III (amiodarone, sotalol), ebe ọ bụ na ahụmịhe nke iji moxifloxacin na ndị ọrịa a. organic. Ekwesịrị iji nlezianya kee Moxifloxacin, ebe ọ bụ na enweghị ike ịgbakwunye moxifloxacin na ọnọdụ ndị a:

n'ime ndị ọrịa na-anata ọgwụgwọ na-eji ọgwụ na-agbatị oge QT (cisapride, erythromycin, ọgwụ antipsychotic, tricyclic antidepressants),

n'ime ndị ọrịa nwere ọnọdụ nke na-emetụta arrhythmias, dị ka bradycardia dị oke egwu, oke myocardial ischemia,

n'ime ndị ọrịa nwere ọrịa cirrhosis, ebe ọ bụ na ọnụnọ nke ndọtị QT na ha enweghị ike ịpụ,

n'ime ụmụ nwanyị ma ọ bụ ndị agadi nwere mmerụ ahụ nke nwere ike ịmatakwu ọgwụ ndị na-agbatị oge Qt.

Ọ bụrụ na ihe mgbaàmà nke ọrịa arrhythmia na-apụta n'oge ọgwụgwọ moxifloxacin, ị kwesịrị ịkwụsị ị takingụ ọgwụ ahụ wee mee ECG.

Ọgwụ Plevilox: ntuziaka maka ojiji

Ọgwụ Plevilox nke na-egbu egbu na-enye gị ohere ịlụ ọgụ n'ọtụtụ ọrịa, ihe ndị na - akpata ya nke microorganisms nwere mmetụta na-emetụta ya. Agbanyeghị, ekwesịrị ịde ọgwụ ahụ naanị n’aka onye ọkachamara, n’ihi na ọgwụ ịchọrọ onwe ya nwere ike ibute nsonaazụ na-enweghị atụ.

Plevilox na-enye gị ohere ịlụ ọgụ n'ọtụtụ ọrịa, ihe ndị na - akpata ya nke microorganisms nke na-emetụta ihe ọ na-eme.

14 Analogs

Ọ bụrụ na enwere ọgwụ mgbochi ọgwụ ma ọ bụ na ọnụnọ ya na ahịa ọgwụ n'oge ịzụta, ịnwere ike inye mmasị nke otu ọgwụ ndị a:

• Maxiflox
• Alvelon-MF,
• Akwukwo
• Akara,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Mgbaji moxifloxacin,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), obodo Balakovo

Ọgwụ nke anọ na-eji ọgwụ nje fluoroquinolone eme ihe. Nsonaazụ ahụ fọrọ nke nta ka o buru amụma 100%. Mmetụta ọghọm dị ole na ole Edere m ya maka usoro ọgwụgwọ siri ike nke urethritis na prostatitis.

Tatyana Sidorova, 38 afọ, obodo Dzerzhinsk

Site n'enyemaka nke ọgwụ nje a, a gbakere nke mycoplasmosis. Usoro akara usoro dị mma - oge 1 kwa ụbọchị, enweghị nlọghachi ọzọ nke ọrịa yana ihe ịrịba ama ọ bụla. Emezuru mmetụta a n'ime ụbọchị 8-9 nke ị theụ ọgwụ.

Kristina Verina, afọ 25, obodo Zelenogorsk

N’ụlọ ọgwụ, a chọpụtara na m nwere ọrịa nje oyi ịba, na mgbe nke ahụ gasịrị, ha tinyere m n’ụlọ ọgwụ ụbọchị iri. Mgbe ebugharị ya na ọgwụ gbasara ọgwụ, ana ede ọgwụ a yana doxycycline. Ahụghị m mmetụta ọ bụla na-egosi na ntuziaka ahụ, enweghị mgbakasị ahụ n'oge ị ofụ ọgwụ niile. Ugbu a, agbakeela m, obi adị m mma.

Vera Ignatyeva, onye gbara afọ 34, bụ obodo Kalach-on-Don

Mgbe m hụrụ cystitis, amalitere m iji Aquamox, mana enwere m nfụkasị ya. Dọkịta ji plevilox dochie ya. Ahụ m were ọgwụ a. E wepụrụ ọrịa ahụ n'ime izu 1.5 nke nchịkwa ọgwụ mgbe niile na usoro ọgwụgwọ egosipụtara.

Angelina Marinina, onye gbara afọ 44, obodo Vladimir

Ejiri ya ọgwụ ndị a maka oyi baa ya. Ọgwụ nje dị irè nke na-enyere aka ngwa ngwa. Agbanyeghị, mgbe m usingụchara ọgwụ ahụ, akwụsịrị m isi. Dọkịta kwuru na nke a bụ ihe juru ebe niile. Aghaghị m ị toụ Diflucan ọzọ.

Releasedị mgbapụta Plevilox

Mbadamba ihe mkpuchi 400 mg, mbadamba 5 nke kaadiboodu 1,

Mbadamba ihe mkpuchi 400 mg, mbadamba 7 nke kaadiboodu 1,

Mbadamba ihe mkpuchi 400 mg, mbadamba 10 nke kaadiboodu 1,

Mbadamba ihe mkpuchi 400 mg, mbadamba 7 nke kaadiboodu 2,

Mbadamba ihe mkpuchi 400 mg, mbadamba 10 nke kaadiboodu 2,

Ngwunye ọgwụ mkpuchi 400 mg, akpa polyethylene (sachet) 100 ike (nnukwu) polymer 1,
Ngwunye ọgwụ mkpuchi 400 mg, akpa rọba (akpa) 500 ike (nnukwu) polymer 1,
Mkpụrụ mbadamba ihe mkpuchi 400 mg, akpa rọba (akpa) 1000 ike (nnukwu) polymer 1,

Nhazi ATX:

J antimicrobials maka iji usoro

Ọgwụ J01 ọgwụ mgbochi iji maka oge niile

Antibacterials J01M - usoro nkpuchi nke quinolone

Nkọwa maka ọgwụ Plevilox edepụtara na ibe a nke saịtị anyị nwere ike iji ya mee ihe kwa ụbọchị.

Dodoụ ọgwụ ọdoụ Overụ gabigara ókè

Mgbaàmà: enwere ike mbelata nke ọrụ, ụra, vomiting, afọ ọsịsa, ahuhu mmadu dum, ahuhu. Ọgwụ: lavage gastric (n’ime elekere abụọ mbụ ka mmụchara), nlere anya, usoro ọgwụgwọ Symptomatic na nyocha ECG. Ọ nweghị ọgwụ mgbochi akọwapụtara ọ dị mkpa iji hụ na mmiri ga-ezuru gị n'ahụ gị mgbe ị na-ejide ya.

Ndụmọdụ ndị pụrụ iche maka iji ọgwụ ahụ

Iji belata ihe ize ndụ nke ịmalite iguzogide moxifloxacin na iji nọgide na-adị irè nke ihe ndị na-egbochi nje, moxifloxacin ka a ga-ederịrị naanị maka ọgwụgwọ nke ọrịa ndị ọrịa na-ebute na ọgwụ a. N'oge ọgwụgwọ, ọ dị mkpa ileba anya na ECG (ịgbatị oge nke QT, arrhythmias ventricular). Ogo ịgbatị oge nke oge QT nwere ike ịbawanye elu site na ị ofụ ọgwụ ọfụma, yabụ ogo a tụrụ aro agaghị agafe. Associatedgbatịkwu oge nke QT na-etinyekwu n'ihe ize ndụ nke arrhythmias ventricular, gụnyere flicker-flutter. N'oge ọgwụgwọ na fluoroquinolones, gụnyere moxifloxacin, karịsịa na ndị agadi agadi na-anata glucocorticosteroids, mmepe nke tendonitis na tendon rupture ga-ekwe omume. Na ngosipụta mbụ nke ihe mgbu ma ọ bụ ọnya na saịtị mmerụ ahụ, ekwesịrị ịkwụsị ọgwụ ahụ ma belata aka na aka ahụ. N'ihe banyere oke ọgbụgbọ n'oge ọgwụgwọ moxifloxacin, ekwesịrị ịkwụsị ọgwụ ahụ ma kwekwaa usoro ọgwụgwọ kwesịrị ekwesị. N'ọnọdụ ụfọdụ, mmeghachi omume nfụkasị ahụ nwere ike ịmalite, gụnyere anafilactic na-eyi ndụ egwu. N'ọnọdụ ndị a, ekwesịrị ịkwụsị moxifloxacin na ihe dị mkpa (gụnyere mgbochi ụjọ) a ga-enyerịrị ndị ọrụ: glucocorticosteroids, norepinephrine, antihistamines. Moxifloxacin enweghị ihe nzuzo fototoxic. Agbanyeghị, ndị ọrịa na-anata moxifloxacin kwesịrị izere ọkụ ọkụ na radieshon ultraviolet. N'agbanyeghị eziokwu ahụ na moxifloxacin adịkarịghị akpata mmeghachi omume akwara site na sistemụ akwara etiti, ndị ọrịa kwesịrị ịma mmeghachi omume ha na ọgwụ ahụ tupu ha akwọ ụgbọala / igwe na-ebugharị.