Liraglutide maka ọgwụgwọ nke oke ibu: ntụziaka nke ọgwụ

Rada na-ezo aka na ngwaọrụ dị ka Liraglutid. A na-eji ya iji chịkwaa glucose na ọbara nke ndị ọrịa mamịrị. A na-ahụkarị ọgwụ ahụ n'okpuru aha Viktoza ma ọ bụ Saksenda.

Liraglutide bụ ihe dị ike dị na ya nke ejiri kee ya. Ọrụ kachasị dị na mmiri a bụ iji belata oke shuga dị n’ọbara.

Jiri ngwaahịa a nke ọma, ebe ọ nwere nsonaazụ yana contraindications. Tupu nhọpụta ahụ, dọkịta ahụ na-enyocha ma na-enyocha ihe osise banyere ọrịa ahụ. N’ọdịnihu, aga-enyocha usoro ọgwụgwọ iji gbochie mmepe nke hypoglycemia na nsogbu ndị ọzọ.

Gịnị bụ liraglutide

Na 2009, ọgwụ liraglutide pụtara na Russia, nke a na-emepụta na Denmark ma jiri ya na-agwọ ọrịa shuga na-adabereghị na insulin. Akụkụ bụ isi bụ agonist (nnomi) nke glucagon-peptide GLP-1, ihe fọrọ nke nta na-adịghị iche na analog nke mmadụ, yabụ anụ ahụ amataghị ya dị ka onye nnọchi anya mba ọzọ.

Uzo eji eme ihe maka ifelata

Ngwá ọrụ dị n'ụdị mkpụrụ sirinji maka ọgwụ ntụtụ. Site na ikpughere anụ ahụ, ọ na - eme ka mmiri ọgwụ insulin dinaa ma belata hyperlycemia. Achọpụtara na ọkara nke ndị ọrịa, ogo ahụ belatara 5-10% n'ime ọnwa eji. Ọkụ na-egbu oke ma na -efu oke ibu n'ihi mkpochapụ nke agụụ na ike oriri. Liraglutide maka ọgwụgwọ nke oke ibu nwere ihe ndị a:

• lowers ọbara shuga
• na-abawanye nri afọ iri,
• Dabere na nyocha, na-egbochi agụụ.

Ọgwụ na liraglutide

Ọkpụkpụ nke nwere ihe ahụ nwere otu aka ahụ. Enweghị mbadamba adịghị. Nke a bụ ọgwụ Viktoza na Saksenda ya (nwere otu arụ ọrụ na-arụ ọrụ, mana ndị nrụpụta ọzọ mepụtara). A na-eji ọgwụ abụọ ahụ agwọ ọrịa shuga, na -ebu ibu na ndị ọrịa okenye. Edere ha maka ndekọta ahụ mmadụ karịrị 30 ma ọ bụ 27, ma ọ bụrụ na enwere ọbara mgbali elu.

Ebumnuche bụ ebumnuche nke liraglutide bụ iji nyere pancreas aka na imepụta insulin homonụ, ihe ndị ọzọ bụ imezi mgbanwe glucose na ume, ọ bụghị abụba. Mkpịsị sirinji Victoza nwere ihe dị n'ọrụ, na-emeju na sodium hydrogen phosphate dihydrate, phenol, sodium hydroxide, mmiri na propylene glycol. Otu sirinji nwere 3 ml nke ihe ngwọta, nkezi ahịa ahịa bụ $ 158 ma ọ bụ 9,500 rubles.

Enwere ike dochie Victoza maka ịba oke ibu site na Saxenda, ọ dịkwa n'ụdị nke pensụl, mana 5 pcs ugbua. 3 ml nke ihe ngwọta nke ọ bụla (na-eri 27 puku rubles). Ọzọkwa, ihe mejupụtara ahụ gụnyere propylene glycol, sodium hydroxide, phenol, sodium hydrogen phosphate dihydrate (ya na ihe mejupụtara nke Viktoza). N'adịghị ka Victoza, Saxenda nwere ntakịrị mmetụta ọ bụla.

Ihe ngbanwe

Mmachibido iwu zuru oke banyere iji ọgwụ nwere Liraglutide:

• usoro mkpali na nri diges,
• nsogbu uche
• ọrịa imeju, pancreatitis,
• afọ ime, lactation,
• ụdị shuga 1
• mmanya na-egbu egbu n'oge ọgwụgwọ (ndakọrịta agbanwebeghị),
• ọrịa mamịrị ketoacidosis,
• arụ ọrụ ezumike, imeju,
• paresis nke afo
• hypersensitivity na ihe mejupụtara.

Ikwe contraindications nke iji ngwaahịa a na-eme liraglutide:

• obi na ọrịa vaskụla,
• obi obara
• ị medicationsụ ọgwụ nwere GLP-1,
• gbara afọ 18 na ihe karịrị afọ 75,
• nnata nke maka ibu n'ibu.

Nsonaazụ

Ndị na-a theụ ọgwụ ahụ nwere ike ịmaliteghachi mmeghachi omume na-adịghị mma:

• hypoglycemia,
• nri riri
• nsogbu ahu
• afọ ntachi, afọ ọsịsa, belching,
• isi ọwụwa
• akpịrị ịkpọ nkụ
• ịda mba, ike ọgwụgwụ, nkụda mmụọ, arụmọrụ belatara,
• anorexia.

Ntụziaka maka iji Liraglutida

A na-edozi Saksenda na Viktoza naanị subcutaneously, otu ugboro kwa ụbọchị. Ọ ka mma ịhọrọ maka ịgba ntụtụ, afọ ma ọ bụ ubu. Usoro izizi ga-abụ 1.8 mg, ka oge na-aga, enwere ike ibute ya ruo 3 mg. Cangaghị abanye ntụtụ ọnụọgụ abụọ maka otu ụbọchị. Oge ọgwụgwọ ọ ga-ewe bụ ọnwa anọ ruo otu afọ, ọ bara uru igwu egwuregwu n'otu oge, soro usoro nri. Na mkpokọ liraglutide, thiazolidinediones na metformin ka a ga-edenye ya.

Etu esi eji pen eji eji sirinji eme ihe

A na-ahụzi azịza ya naanị subcutaneously. Liquid kwesịrị ịdị n ’ụlọ okpomọkụ. Ihe eji:

1. Wepu okpu ahụ site na aka ahụ, wepu akara ahụ na agịga ahụ, na-ejide ya site na okpu ahụ, fanye ya n'ọnụ ọnụ. Tụgharịa ya site na eri, kpọchie agịga.
2. Wepu ikuku site na iwepu okpu site na agịga ma tụgharịa njedebe na ala. Ikwanye ntụtụ iji hapụ ikuku, pịa bọtịnụ ka otu mkpọda si n'ọnụ ọnụ agịga ga-esi.
3. Tụgharịa bọtịnụ ogwu ahụ ka ọ dị chọrọ ka ọ dị na ọ̀tụ̀tụ̀ site na ịgbanye sirinji. Nọmba dị na igbe ahụ ga - egosi ogo ha.
4. Oge ọ bụla ịchọrọ ịgbanye ọgwụ n’ebe dị iche. Jiri ihicha mmanya hichaa ebe a na-agba gị nwuo, kpọọ nkụ, jiri otu aka jide ya, ma soro ọzọ. Tinye agịga ahụ, hapụ mpempe ahụ, pịa bọtịnụ ahụ n'aka, hapụ mgbe sekọnd iri gasịrị.
5. Wepu agịga ahụ n’akpụkpọ ahụ mgbe ị na-ejide bọtịnụ. Jiri akwa nhicha mmachi dochie saịtị ntụtụ gị, gbaa mbọ hụ na 0 dị na windo ahụ.
6. Kwupu agịga ahụ, gbanye okpu ahụ, na-atụgharị ya, yọpu agịga ahụ, tụfuo. Dochie okpu.
7. Debe sirinji na nkwakọ ngwaahịa mbụ ya. Amachibidoro ịhapụ agị ahụ n'ahụ ma were ya ugboro abụọ.

Analogs nke Victoza na Saxends

Jiri ngwaọrụ ndị a nwere ike ịzụta na dochie dochie ọgwụ ndị a:

1. Forsyga - 2500 p., Lowers shuga ọbara.
2. Orsoten - 650 p., Capsules maka iwelata ibu, mee ka metabolism glucogone mee ka ọ dị ọkụ.
3. Liksumiya - 6750 p., Lowers shuga ọbara.
4. Ximia - 2000 p., Irè na oke ibu.
5. Reduxin - 1400 rubles, belata ibu, na - enyere aka gbaa abụba.
6. Diagninide - dị ọnụ ala, 200 rubles, na-enyere aka oke ibu.
7. Belvik - 13,000 rubles, belata agụụ, ereghị ya eze na Russia.
8. Baeta - 8000 rubles, peptide amino acid nke na-ebelata ịba uru ma na-ebelata agụụ, na-emetụta ndị na-anabata ọgwụ.

Ngwakọta, ụdị ntọhapụ na usoro ọgwụ

A na-emepụta ọgwụ ahụ n'ụdị nke agbanwe agbanwe nke enweghị agba, nke e mere maka nchịkwa subcutaneous. Akụkụ bụ isi bụ ihe Lyraglutide.

Na mgbakwunye na ya, ihe ndị mejupụtara gụnyere:

• propylene glycol
• hydrochloric acid
• phenol
• sodium hydrogen phosphate,
• mmiri.

Ọ bụ ihe mejupụtara a ka echere na ọ kachasị adaba iji mezuo ọrụ ndị ekenyela ọgwụ ahụ.

N'okpuru mmetụta nke ihe mejupụtara, usoro nke imepụta insulin site na mkpụrụ ndụ beta na-agbatịkwu. N'ihi nke a, akwara na anụ ahụ nke anụ ahụ na - arụ ọrụ glucose ma na - emegharị ya n’etiti mkpụrụ ndụ, nke na - enyere aka belata oriri shuga n’ime ọbara. Dabere na nke a, anyị nwere ike ikwu na ọgwụ a bụ hypoglycemic.

Ike nke ọgwụ dị elu, a na-eji ya ekpughere ya ogologo oge. Site na iwebata ọgwụ 1 oge kwa ụbọchị, nsonaazụ ya na-adịgide ruo awa 24.

Ihe ngosi na contraindications

Tupu iji liraglutide, ịkwesịrị ịgụ ntuziaka ma jide n'aka na ngwaọrụ a dabara adaba maka otu onye ọrịa. Ọbụna ndị dọkịta kwesịrị ime nyocha nke mbụ iji zere nsogbu. Anabataghị ịnara ọgwụ ahụ n'onwe gị.

A na-eji ọgwụ maka ụdị shuga 2 mee ihe. A na-ahụta ya dị ka ihe inyeaka yana iji ya na ọgwụ ndị ọzọ nke otu hypoglycemic otu. Ma mgbe ụfọdụ Lyraglutide dịkwa irè na monotherapy.

Mkpa maka nyocha nke mbido onye ọrịa na-ebilite n'ihi contraindications dị na ọgwụ ahụ.

A na - akpọ ụfọdụ n'ime ha:

• uche anụ ahụ ọ bụla nke mejupụtara nke mejupụtara,
• ọrịa imeju
• arụ ọrụ akụrụ
• ọnụnọ nke usoro mkpali na ngụgụ nri,
• ụdị ọrịa shuga mbụ
• ọria aru
• obi obara
• ọrịa endocrine
• oge ime
• lactation.

Na mgbakwunye na contraindications siri ike, a ka nwere oke:

• ọrịa nke obi usoro,
• afọ onye ọrịa dị afọ 18,
• agadi nwoke.

N'okwu ndị a, enwere ihe ọghọm nke nsogbu, mana n'okpuru nlekọta nke ọkachamara ọ nwere ike ịdọpụ ya. Ya mere, oge ụfọdụ a na-enye ndị ọrịa Liraglutid ọgwụ.

Ntụziaka maka ojiji

A na-eji ọgwụ ahụ eme ihe naanị maka ọgwụ ntụtụ, nke a kwesịrị iji subcutaneously. Amachibidoro ịraụ ọgwụ ma ọ bụ ọgwụ intramuscular.

Ebe kachasị adabara maka inje bụ mgbidi afọ, ogwe aka ma ọ bụ ubu. Ọ dị mkpa ka a gbanwee ebe ndị a na-agba agba mgbe niile ka lipodystrophy ghara ime. Iwu ọzọ - iwebata ọgwụ kwesịrị ka emee n’otu oge.

A na-ekpebi dose nke ọgwụ ahụ n’otu n’otu. Ọtụtụ mgbe, ọgwụgwọ na-amalite site na ọkara nke 0.6 mg. A na-eme ndị ịgba agba otu ugboro n'ụbọchị. Ọ bụrụ na ọ dị mkpa, a na-a increasedụ usoro onunu ogwu ka ọ bụrụ 1.2 rue ọbụna 1.8 mg. Ojiji nke liraglutide na ihe kariri 1.8 mg ekwesighi.

Ọtụtụ mgbe, na mgbakwunye na ọgwụ a, a na-eji ngwaahịa ndị dabeere na Metformin eme ihe.

Iji gbochie ọnọdụ hypoglycemic, a ga-enyocha usoro ọgwụgwọ ya. Gbalia ilelee shuga di na ọbara gi ma dozie usoro ogwu gi. Changesme mgbanwe ọ bụla na-enweghị nkwado nke onye ọkachamara bụ ihe a na-achọghị.

Ntụziaka vidiyo maka nchịkwa subcutaneous nke ọgwụ:

Mmekọrịta na ọgwụ ndị ọzọ

Liraglutide nwere ikike ime ka ịdị irè nke ọgwụ ndị ọzọ. N'ihi ya, ndị ọrịa kwesịrị ịgwa dọkịta na-aga ya ọgwụ ọ bụla e ji eme ihe ka ha nwee ike ịkọwa usoro ọgwụgwọ zuru oke. Ọtụtụ mgbe, nsonaazụ na-apụta n'ihi eziokwu ahụ bụ na onye ọrịa ahụ na-eji ọgwụ ekwe ekwe.

Utionkpachara anya na mmezi usoro ọgwụgwọ dị mkpa maka ọgwụ ndị a:

• ndị ọrịa hypoglycemic
• ihe mgbochi beta,
• diuretics
• Ihe mgbochi ACE
• ọgwụ anabolic
• homonụ na-egbochi afọ ime,
• ọgwụ antimycotic
• salicylates, wdg.

A na-ahapụkarị inye nkwado nke liraglutide na ọgwụ ndị ọzọ, mana ọ na-adịkarị mkpa ịlele ọbara onye ọrịa maka ọdịnaya shuga ya. Na enweghị ọnọdụ dị omimi, usoro ịba ụba na-abawanye, na-egosipụta nke ihe ịrịba ama nke hypoglycemia, ekwesịrị ibelata ya.

Nkwadebe nke ihe di otu a na mbadamba

Ihe kpatara ndi okachasi kwesiri iji analogues nke ogwu a nwere ike di iche. Maka ụfọdụ ndị ọrịa, usoro ọgwụgwọ ahụ adabaghị n'ihi mgbochi, ndị ọzọ na-eme mkpesa nke mmetụta ndị ọzọ, maka ụfọdụ, ọnụahịa ahụ nwere ike iyi adịghị anabata.

Jiri ihe ndị a dochie ọgwụ a:

1. Anwụ Satọde. Ndabere ya bụ Repaglinide. Ha na-ahapụ ya n'ụdị mbadamba. Dọkịta na-edepụta ọgwụ nke ọgwụ ahụ, dabere na njirimara nke foto ọrịa ahụ. Nweghị ike ịmalite ịnwe Novonorm n'onwe gị, n'ihi na ọ nwere contraindications.
2. Reduxin. Ọgwụ nwere mmetụta hypoglycemic. Ngwakọta ya jikọtara ihe abụọ - Metformin na Sibutramine. Enwere ike iji Reduxine mee ihe na isi mkpuchi ma ọ bụ mbadamba.
3. Diaglinide. Ezubere maka nchịkwa ọnụ, lekwasịrị anya na ndị ọrịa nwere ọrịa shuga. Isi ihe dị na ya mejupụtara bụ Repaglinide. Ngwá ọrụ na-enyere aka ịchịkwa ọkwa glucose.
4. Forsyga. Ngwakọta ọrụ ya bụ Dapagliflozin. Nri ahụ nwere mmetụta hypoglycemic, nwere ike inye aka n'ibu oke. Iji ya, ịkwesịrị ịgbaso ntuziaka ahụike.

Echiche onye ọrịa

Site na nyocha nke ndị ọrịa weere Liraglutide, anyị nwere ike ikwubi na onye ọ bụla anabataghị ọgwụ ahụ nke ọma. Nkwupụta bụ mmetụta siri ike n'akụkụ mgbe ị nwesịrị. Ọtụtụ na-atụle mmetụta nke ibu belata bụ ezigbo ego.

Agwaghị m Liraglutide ogologo oge. Na mbụ ihe niile dị mma, ọbụnadị enweghị mmeghachi omume ọ bụla na-adịghị mma juru m anya. Nyocha ahụ wee kpughee na enwere m ọrịa pancreatitis. Ekwesịrị m ịjụ ọgwụ ọjọọ.

Mmalite ọgwụgwọ nke ọgwụ a bụ nnọọ egwu. Ahụ́ na-egbu m mgbu, isi na-egbu m mgbu mgbe niile, na n’ihi nsogbu nrụgide, o siri ike ịrụ ọrụ na ibili ụra. Wanted chọburu ịrịọ maka ọgwụ edochi. Ọ kwụsịrị na ọkwa shuga dị ka ihe dị mma ma kwụsie ike. Mgbe ahụ, enwere ike iji ahụ ahụ, n'ihi na mgbaàmà niile na-adịghị mma n'anya gwụsịrị. Anọgidere m ọgwụgwọ ahụ ruo ugbu a. Achọpụtara m na ọ na - enyere aka ifelata, n'ihi na agụụ na - ebelata. Ruo ọkara afọ, m nwere 15 n'arọ erughị ala, nke nyere m ohere inwe ahụ iru ala karị - mgbakwunye ahụ kwụsịrị.

Ana m eji Liraglutid n'oge na-adịbeghị anya, mana ọ dabara na m. Ọrịa shuga adaala na ọkwa nkịtị, enweghị mmeghachi omume na-adịghị mma, ọ bụ ezie na enwere m nsogbu. Ọ ga-amasị m ifelata (m nụrụ na a na-ejikwa ya maka nke a), mana ruo ugbu a ịdị arọ ya dị obere, naanị 3 n'arọ.

Ọ bụghị onye ọ bụla nwere ike ịzụta ọgwụ a, ebe ọ bụ otu n'ime ihe ndị kachasị ọnụ. Ọnụ ego dị na nso nke 7-10 puku rubles.