Glibomet (Glibomet) - ntuziaka maka ojiji
Glybomet nke ọgwụ ahụ nwere mmetụta hypoglycemic na hypolipPs. Dabere na ntuziaka nke Glibomet, ọgwụ na-akpali nzuzo nke insulin, nke mmadụ na-emepụta, na-eme ka ọgụgụ isi nke akwara anụ ahụ niile na-amụba. Ọgwụ na-emepụta ntọhapụ nke insulin, ebe ọ na-egbochi lipolysis na anụ ahụ. Na -emechi glycogenolysis na imeju, Glybomet na-ebelata nguzo nke ọbara, na-arụ ọrụ antiarrhythmic. Ihe mejupụtara nke Glibomet, nke gụnyere glibenclamide na metformin, nwere mmetụta jikọtara n'ahụ ahụ onye ọrịa, ebe glibenclamide na-ahụ maka mmepụta insulin, na metformin na-ebelata nnabata glucose ma na-edozi metabolism lipid.
Ihe na-egosi Glibometa
A na-eji Glibomet mee ihe iji gwọọ ọrịa mellitus 2 dị ka iwu, mgbe usoro ọgwụgwọ gasịrị ma ọ bụrụ na ọ nweghị ike. A na-amalitekwa Glybomet mgbe ọ consumụsịrị ọgwụ hypoglycemic nke ọgwụ na-enweghị ọgwụgwọ ọgwụgwọ. Na-ekpe ikpe site na nyocha nke Glibomet, ọgwụ kachasị dị irè ma ọ bụrụ na onye ọrịa ahụ na-agbaso ọgwụgwọ na nri.
Ofzọ nke iji Glybomet na usoro onunu ogwu
N'ịgbaso ntuziaka nke Glibomet, a na-a theụ ọgwụ ahụ n'oge nri. Dabere n'ọnọdụ a na-eme ka metabolism dị na ọkwa shuga dị n'ọbara onye ọrịa, a na-eme usoro ahụ, a na-eme ya otu otu, na-eburu n'uche ọnọdụ onye ahụ. Ha malitere iji Glybomet were mbadamba 1, 2 ma ọ bụ 3, na-eji nwayọọ nwayọọ na-agbadata ọgwụ nke kwekọrọ n'ụzọ ọrịa ahụ. Nleta kachasị mma nke ọgwụ Glibomet, dịka ntuziaka ahụ si dị, ugboro abụọ n'ụbọchị - n'ụtụtụ na mgbede. A naghị atụ aro ka iwelie dose nke ị theụ ọgwụ kwa ụbọchị maka ihe karịrị mbadamba ise.
Ihe mgbochi iji Glibomet
Ihe dị mkpa contraindication ị takingụ ọgwụ, dị ka ntụziaka nke Glibomet, bụ hypersensitivity na akụkụ nke ọgwụ mejupụtara. Enweghi ike iji ọgwụ a maka ọrịa ndị na-esonụ: coma mamịrị, ọrịa mamịrị, hypoglycemia, ụdị 1 diabetes mellitus. Amachibidoro ị Gụ ọgwụ Glybomet n'oge afọ ime na inye nwa ara.
Nsonaazụ Glybomet
Iwere Glybomet nwere ike ibute ọgbụgbọ na nnukwu ọgbụgbọ. Nyocha nke Glybomet gosipụtara na mmeghachi omume nfụkasị ahụ ga-ekwe omume, mmetụta hypoglycemic, nke na-eduga n'ịbelata ọdịnaya nke mkpụrụ ndụ ọbara uhie, platelet na granulocytes n'ọbara. N'otu oge ahụ, hemolytic anaemia, ịba ọcha n'anya na cholestatic jaundice na-etolite. N'ọnọdụ ụfọdụ nke ị theụ ọgwụ Glibomet, arthralgia na hyperthermia hụrụ. Nyocha na Glybomet na-akwado data banyere ịdị elu nke protein na mmamịrị na ngosipụta nke fotoensitivity.
Ihe nrịba ama nke Glybomet
N'ụfọdụ, enwere ọrịa, enwere ike dochie ọgwụ Glibomet na analogues. Lodị analọg nke Glibomet bụ ọgwụ Glyukovans na Glyurenorm. Ijikwa ogwu Glibenclamide abụọ na Metformin na enweghị ọgwụ ndị ọzọ nwere ike iji dị ka analog nke Glibomet, mana nsonaazụ ahụ ga-aka njọ karịa mgbe ị na-ewere otu ọgwụ siri ike.
Mwepụta wepụtara ya na ihe mejupụtara
A na-eme mbadamba glybomet nwere ihe eji arụ ọrụ:
- Metformin hydrochloride - 400 mg,
- Glibenclamide - 2,5 mg.
Ihe inye aka nke Glibomet bu magnesium stearate, microcrystalline cellulose, colloidal silicon dioxide, glycerol, gelatin, stachi ọka, talc.
N'ime blister maka mbadamba 20.
Mlọ ọgwụ
Glibomet bụ ọgwụ ejiri ọgwụ hypoglycemic jikọtara ọnụ sitere na usoro nke biguanide na sulfonylurea nke ọgbọ nke abụọ. Ihe e ji mara ya bụ ọgwụ akwara puru iche.
Glibenclamide bụ onye otu nke sistemu nke mmụọ nke II ma na-akpali njikọ nke insulin site na iwetula ọnụ ụzọ maka mgbakasị glucose beta-cell. Ihe ahụ na-abawanye nnabata insulin na ogo nke jikọtara ya na mkpụrụ ndụ, na-eme ka ntọhapụ nke insulin, na-abawanye mmetụta ya na ntinye glucose site na umeji na akwara, ma na-egbochi lipolysis na adipose anụ ahụ. A na-ahụ mmetụta ya na ọkwa nke abụọ nke insulin insulin.
Metformin bụ nke biguanides. Ọ na - akpali mmetụta nke anụ ahụ na nsonaazụ insulin (na - eme ka mmụba insulin dị n'ọbara postreceptor, na - egbochi mmetụta nke glucose na eriri afọ, na - egbochi gluconeogenesis ma na - emetụta oke nke metabolism, na - enyere aka belata oke ibu na ndị ọrịa nwere ọrịa mellitus, enwekwara mmetụta nke fibrinolytic n'ihi mgbochi nke anụ ahụ na - egbochi ụdịrị plasminogen activates inhibitor.
A na-ahụ mmetụta hypoglycemic nke Glibomet ruo awa 2 mgbe nchịkwa na-adịgide ruo awa 12. Ngwakọta mmekọrịta nke ọgwụ abụọ a na - arụ ọrụ nke ọgwụ ahụ, nke mejupụtara mkpali na - eme ka sulfonylurea na - eme ka insulin nke ihe insulin (ihe a na - eme ya) na mmetụta nke biguanide na adipose na akwara anụ ahụ (mmụba dị elu na mgbakwunye glucose - mmetụta extra-pancreatic), yana anụ ahụ (na-ebelata gluconeogenesis), na-eme ka o kwe omume otu uzo kwesiri iji belata itinye uche n’ime ihe obula. Nke a na - egbochi mkpali nke mkpụrụ ndụ beta na - egbochi ma na - ebelata ọghọm dysfunctions nke akụkụ a, ma na - enyekwa aka na nchekwa nke ị drugsụ ọgwụ hypoglycemic ma belata ọnọdụ nke mmetụta.
Mlọ ọgwụ
Glibenclamide nwere nnukwu ọsọ na oke zuru oke (84%) na-abanye na ngọngọ nri. A na-enweta ntinye uche kachasị 1-2 awa mgbe nchịkwa gasịrị. Ihe a na - ejikọ protein protein plasma site na 97% ma ọ fọchara nke ọma na imeju, na - akpụ metabolites na - adịghị arụ ọrụ. Glibenclamide dịpụrụ adịpụ 50% site na akụrụ na 50% na bile. Ọkara ndụ bụ 5-10 awa.
Ogo ogo nnabata nke metformin na n’ime nri diges di elu. A na-ekesa onyinye ahụ ngwa ngwa n’akpụkpọ ahụ niile ma o nweghị ihe jikọrọ ya na protin plasma. Ọ fọrọ nke nta ka Metformin ghara ịlụ ọrụ n'ime ahụ ma wepụta ya site na akụrụ na akụkụ afọ ya. Iwepu ọkara ndụ bụ ihe dịka awa asaa.
Ntụziaka maka iji Glibomet: usoro na usoro onunu ogwu
Mbadamba ụrọ na-ewere nri ọnụ.
Dọkịta depụtara usoro onunu ogwu ya na oge ọgwụgwọ iche iche dabere n'ihe ngosipụta nke ụlọ ọgwụ, na-eburu n'uche ịba ụba nke glucose n'ọbara na steeti metabolism metabolism.
Ọgwụ nke mbụ bụ mbadamba 1-3 kwa ụbọchị. N'oge ọgwụgwọ, onye ọrịa ahọpụtara otu ụzọ dị irè iji mezuo usoro mgbochi glucose ọbara dị mma.
Oke kachasị maka Glybomet kwa ụbọchị ekwesịghị ịfe mbadamba 6.
Dodoụbiga ya ókè
Site na mmụba nke Glibomet, ọ ga-ekwe omume ịzụlite lactic acidosis nke a na-eme na metformin, na hypoglycemia kpatara nke glibenclamide.
Ihe mgbaàmà nke lactic acidosis bụ adịghị ike siri ike, mbelata ọbara mgbali, reflex bradyarrhythmia, iro ụra, ọgba aghara na ọnwụ nke nsụ, hypothermia, nsogbu iku ume, mgbu akwara, afọ ọsịsa, ọgbụgbọ, ọgbụgbọ.
Ihe mgbaàmà hypoglycemia gụnyere isi ọwụwa, mmetụta nke ụjọ, nsogbu akwara ozi nwa oge, nhazi nke ngagharị, nsogbu ụra, nsogbu ihi ụra, nchekasị n'ozuzu oke, ịma jijiji, paresthesia na oghere ọnya, adịghị ike, pallor nke anụ ahụ, ịba ụba ọsụsọ, palpitations, agụụ. Ọrịa hypoglycemia na-aga n'ihu pụrụ iduga mmadụ njide onwe onye na nkụda mmụọ.
Ọ bụrụ na enyo enyo banyere mmepe nke lactic acidosis, a ga-ewepụrịrị Glibomet ozugbo ma zigara onye ọrịa ahụ n'ụlọ ọgwụ ozugbo. Treatmentzọ kachasị dị irè maka ịdoụbiga mmanya ókè bụ hemodialysis.
A pụrụ ịgwọta hypoglycemia dị nwayọ site na itinye obere shuga, ihe ọ drinksụ orụ ma ọ bụ ihe oriri nwere ọtụtụ carbohydrates (iko tii, jam, mmanụ a honeyụ).
Ọ bụrụ na mmụọ amaghị, ọ na-atụ aro ka itinye ntụtụ 40-80 nke glucose 40% (dextrose) intravenously, wee nye 5-10% dextrose solution. A na-ahapụ nlekọta ọzọ nke 1 mg nke glucagon subcutaneously, intramuscularly ma ọ bụ intravenously. Ọ bụrụ na onye ọrịa ahụ agbakebeghi, ọ dị mkpa ikwugharị usoro nke usoro. Ọ bụrụ na enweghị mmetụta ọfụma dị n'ụlọ ọgwụ, gaa na nlekọta ahụike.
Ntụziaka pụrụ iche
Ọ dị mkpa ịkwụsị ị Gụ Glibomet mgbe mgbaama nke lactic acidosis pụtara n'ụdị adịghị ike n'ozuzu, ọgbụgbọ, mgbu afọ, akwara olu, wee gakwuru dọkịta ozugbo.
A na-atụ aro ka ị were ọgwụ ahụ mgbe niile ilele ọkwa nke creatinine n'ọbara: maka ndị ọrịa nwere ọrụ akụrụ dịkarịsịrị - ọbụlagodi oge 1 kwa afọ, maka ndị ọrịa nwere mgbanye ọkụ na creatinine na ọbara dị nso na oke nke ụkpụrụ na maka ndị agadi - ugboro 2-4 n'afọ.
Ekwesịrị ịkwụsị glybomet ụbọchị abụọ tupu oge ịwa ahụ na-eme atụmatụ iji ọgwụ na-agwọ ọrịa mgbu (azụ azụ ma ọ bụ ọgwụ epidural). Gaa n'ihu were ọgwụ ahụ ka ịmaliteghachi usoro ihe oriri, mana ọ bụghị tupu ụbọchị 2 mgbe ịwachara ahụ, ma ọ bụrụ na egosipụtara ọrụ akụrụ.
N'oge usoro ọgwụgwọ, a na-adụ ọdụ mgbe ị na-eme ihe omume dị egwu yana ịnya ụgbọ ala, ebe ọ bụ na enwere ike ịmalite hypoglycemia na, n'ihi nke a, ibelata ọsọ nke mmeghachi omume psychomotor na ikike itinye uche.
Ofdị irè ọgwụgwọ na-agbasochi anya idebe ọgwụ ndị dọkịta nyere, ndụmọdụ ndị o nyere gbasara usoro mmega ahụ na nri, yana ileba anya na ọkwa glucose ọbara.
Mgbe ị na-eji Glibomet, ị kwesịrị ị fromụ mmanya, ebe ọ bụ na ethanol nwere ike ịkpata hypoglycemia na / ma ọ bụ mmeghachi omume disulfiram (ọnya afọ, ọgbụgbọ, ọgbụgbọ, mmetụta nke ikpo ọkụ na elu ahụ na ihu, isi ọwụwa, isi ọwụwa, tachycardia) .
Mkparịta ụka ọgwụ ọjọọ
Mmetụta nke Glybomet na-abawanye na oge nke nchịkwa beta-blockers, ihe ndị coumarin (warfarin, syncumar), allopurinol, cimetidine, monoamine oxidase inhibitors (MAO), oxytetracycline, sulfanilamides, chloramphenicol, phenylbutazone amileyl amide amide , sulfinpyrazone, miconazole (mgbe a na-ewere ya ọnụ), ethanol.
Mmetụta hypoglycemic nke ọgwụ na-ebelata njikọta glucocorticosteroids, adrenaline, ọgwụ mgbochi, thiazide diuretics na barbiturates, nkwadebe homonụ thyroid.
Nlekọta oge nke beta-egbochi nwere ike kpuchie ihe ịrịba ama nke hypoglycemia, na mgbakwunye na ọsụsọ.
Site na iji Glibomet na oge a na cimetidine, ihe ize ndụ nke ịmalite lactic acidosis na-abawanye, yana ọgwụ anticoagulants, mmetụta ha na-akawanye njọ.
Ihe omuma nke onye oria tolitere lactic acidosis na-abawanye site na ihe omumu x-ray site na iji intravascular iji iodine ndi nwere ihe di iche.
Ihe atụ nke Glibomet bụ: Amaril, Avandamet, Avandaglim, Gluconorm, Glukovans, Glimecomb, Galvus Met, Glyukofast, Bagomet Plus, Combogliz, Metglib, Yanumet.
Nyocha nke Glibomet
N'ime ndị ọrịa na-a theụ ọgwụ ahụ mgbe niile, a na-enwe nyocha dị mma banyere Glibomet, na agbanyeghị, enwere ntụaka banyere obere nsonaazụ. Ọtụtụ ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 2 na-ejikọta ị Gụ ọgwụ Glibomet na ọgwụ ndị ọzọ, ya mere na ha enweghị ike kwenye n'ụzọ ziri ezi ịdị irè nke ọgwụgwọ na ọgwụ ahụ. Peoplefọdụ mmadụ enweghị afọ ojuju nsonaazụ ọgwụgwọ a, ha mechara bido Glomatik analogues, nke na-egosi mkpa ọ dị ịbịaru nso na nhọpụta ọgwụgwọ.
Ọnụnọ nke ihe abụọ na-arụ ọrụ na Glibomet nwere ike n'ụzọ ụfọdụ na-akpalite ịhapụ ibe ọgwụ ahụ. Ekwesiri icheta na n'ihe banyere ọrịa shuga mellitus, ọ bụ naanị dọkịta nwere ike ikpebi ndụmọdụ nke ịkọ ọgwụ a, zụlite usoro ọgwụgwọ ma dozie dose ahụ.
Usoro onunu ogwu na nhazi
A na-ewere ọnụ glybometia n’oge nri.
Ọ bụ dibia a na -eche maka usoro onodu ogwu ya na oge ọkachasị na-ekpebi ihe niile, dabere n'ọkwa glucose dị n'ọbara yana steeti carbohydrate metabolism.
Oru izizi nke Glibomet bu mbadamba 1-3 kwa ubochi, imeghari nke oma iji nweta otutu glucose di n’ọbara. Ekwesịrị iji karịa mbadamba 6 nke ọgwụ ahụ kwa ụbọchị.
