Lisinopril (10 mg, Himfarm AO) Lisinopril

5 mg, 10 mg na mbadamba 20 mg

Otu mbadamba ihe

ike - lisinopril dihydrate 5.5 mg, 11.0 mg ma ọ bụ 22.0 mg

(dika lisinopril 5.0 mg, 10.0 mg ma ọ bụ 20.0 mg)

ndị na-ebu ụzọ: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, calcium stearate.

Mbadamba nkume ndị ahụ dị ọcha ka cylindrical acha uhie uhie na ọdịdị, n'akụkụ nke mbadamba nkume ahụ enwere chamfer, n'akụkụ nke ọzọ - akara chamfer na akara ụlọ ọrụ n'ụdị obe (maka usoro nke 5 na 20 mg).

Mbadamba nkume ndị ahụ dị ọcha ka cylindrical na-acha uhie uhie, n'otu akụkụ nke mbadamba nkume ahụ enwere chamfer na ihe ize ndụ, n'akụkụ nke ọzọ - akara chamfer na akara ụlọ ọrụ n'ụdị obe (maka usoro nke 10 mg).

Ndị na-ere ọgwụ

Ọgwụ ndị na-emetụta usoro renin-angiotensin. Angiotensin-na-agbanwe enzyme (ACF) na-egbochi. Lisinopril.

Usoro ATX C09AA03

FNgwongwo ogwe aka

Mlọ ọgwụ

Iri nri anaghị emetụta nnabata nke ọgwụ. Oke ndọta na plasma ọbara erutela ihe dịka awa 6 ka nchịkwa ọnụ nke lisinopril gasịrị. Bioavailability bụ 29%. Ewezuga njikọ ya na enzyme nke angiotensin na-emegharị, ọ naghị abata na protein ndị ọzọ. Ọ bụ metabolized, a napụ ya kpam kpam site na akụrụ na-agbanweghi. Nkeji ọkara bụ awa 6.6. Lisinopril na-agafe ihe mgbochi placental.

Mlọ ọgwụ

Lisinopril bụ otu nke angiotensin-na-agbanwe enzyme inhibitors. Mwepu ACF na-eduga n'ịbelata mmebi nke angiotensin II (yana mmetụta vasoconstrictor) yana mbelata na nzuzo nke aldosterone. Lisinopril na-egbochikwa mbibi bradykinin, ike vasodepressor peptide. N'ihi ya, ọ na-ebelata ọbara ọgbụgba, ngụkọta akwara akwara, ngụgụ na mgbe ebidoro obi, na-abawanye nkeji oge, iwepụta obi, na-eme ka nnabata myocardial nwee ibu ma mee ka ọbara nwetachaa ụbụrụ ischemic. N'ime ndị ọrịa nwere nnukwu ọrịa myocardial infarction, lisinopril yana nitrates na-ebelata nguzobe akwara ma ọ bụ nkụda obi.

Na-esonye na mweghachi nke ọrụ endothelial mebiri emebi na ndị ọrịa nwere hyperglycemia.

Mbelata ọbara mgbali elu na-amalite otu awa mgbe ị theụsịrị ọgwụ ahụ n'ime ma rute ogo ya ka elekere isii gachara. Ogologo oge nke lisinopril bụ ọgwụ dabere na ihe dị ka awa 24, nke na-enye gị ohere iji ọgwụ ahụ 1 oge kwa ụbọchị. Site na ọgwụgwọ ogologo oge, ịdị irè nke ọgwụ adịghị ebelata. Site na njiri dị elu nke ọgwụgwọ, mgbanwe ndị dị ukwuu na ọbara mgbali (wepu syndrome) adịghị eme.

Ọ bụ ezie na isi mmetụta nke lisinopril nwere njikọ na sistemụ renin-angiotensin-aldosterone, ọgwụ ahụ dịkwa irè n'ọnọdụ ọbara mgbali elu na obere ọdịnaya nke renin.

Na mgbakwunye na mbelata ọbara mgbali, lisinopril na-ebelata albuminuria n'ihi mgbanwe nke akwụkwọ mmụta na akụrụngwa nke akụrụngwa nke akụrụ.

Usoro onunu ogwu na nhazi

A na-ewere Lisinopril ọnụ, n'agbanyeghị nri, oge 1 kwa ụbọchị, ọkacha mma n'otu oge ahụ.

Enwere ike iji Lisinopril mee ihe dị ka monotherapy ma ọ bụ jikọtara ya na ọgwụ ndị ọzọ na-egbochi mmiri.

Na mgbali ọbara, akwara mbụ nke ọgwụ bụ 10 mg. N'ime ndị ọrịa nwere mgbali siri ike nke sistemụ renin-angiotensin-aldosterone (ọkachasị, na mgbali ọbara mgbali, nkụchi obi, ma ọ bụ oke ọbara), mbelata nke ọbara mgbali elu mgbe usoro nke mbụ nwere ike ịpụta. Ya mere, a na-atụ aro ndị ọrịa dị otú a ka ha buru ụzọ ọgwụ mbụ nke 2.5-5 mg n'okpuru nlekọta nke dibịa.

Ọgwụgwọ kwesịrị ịmalite na 5 mg kwa ụbọchị n'ụtụtụ. Oge etiti oge dị n'etiti mmụba onunu ogwu kwesịrị ịbụ opekata mpe atọ. Ọgwụ a na-arụkarị bụ 10-20 mg nke Lisinopril 1 otu oge kwa ụbọchị, yana kacha sọ kwa ụbọchị bụ 40 mg 1 oge kwa ụbọchị. Iji nwetakwuo belata ọbara mgbali, ekwesịrị ijikọ Lisinopril na ọgwụ ndị ọzọ na - egbochi mkpali.

Dị ka ọ na -adịghị, nkezi ọgwụgwọ a na-agbaso bụ 20 mg otu ugboro n'ụbọchị. Ọ bụrụ na enwetaghị ọgwụgwọ ọgwụgwọ achọrọ n'ime izu 2-4, enwere ike ịbawanye dose ahụ.

Ekwesịrị ịkwụsị ọgwụ diuretic ụbọchị 2-3 tupu ịmalite ị ofụ Lisinopril. Ọ bụrụ na enwereghị mwepu ọgwụ diuretics, mgbe ahụ, a na-atụ aro ka ịmalite ọgwụ Lisinopril na 5 mg kwa ụbọchị. Ọ dị mkpa ijikwa ọrụ gbasara akụrụ na ọkwa potassium.

Edebere Lisinopril na mgbakwunye na usoro ọgwụgwọ a nwere na diuretics, cardiac glycosides ma ọ bụ ndị na-egbochi beta. Na nke a, mbido, dịka o kwere mee, ekwesịrị belata ọgwụ nke diuretic. Ọgwụ nke mbụ bụ 2.5 mg n'ụtụtụ. A na-edobe usoro nlekọta ahụ na ọkwa nke mmụba nke 2.5 mg na etiti oge nke izu 2-4. Ọgwụ a na-eme bụ 5-20 mg otu ugboro kwa ụbọchị. A naghị atụ aro ka ọ gafee karịa 35 mg kwa ụbọchị.

N'oge ọgwụgwọ, ịkwesịrị ilebara ọbara ọgbụgba anya, ọrụ akụrụ, ịta ụta nke potassium na sodium n'ọbara ọbara iji zụlite mmepe nke hypotension na nsị metụtara akụrụ.

Nnukwu myocardial infarction na ndị ọrịa nwere hemodynamics kwụ chịm

Ọgwụgwọ na lisinopril nwere ike ịmalite n’ime awa iri abụọ na anọ mgbe ọ kwụsịrị ike myocardial infarction (mgbali ọbara systolic karịrị 100 mmHg, na-enweghị ihe ịrịba ama nke nrụrụ akwara), na mgbakwunye na usoro ọgwụgwọ maka infarction myocardial (ndị nnọchi thrombolytic, acetylsalicylic acid, beta-blockers, nitrates dika akwara intravenous na transdermal).

Usoro mbụ bụ 5 mg, mgbe awa 24 gasịrị - 5 mg ọzọ, mgbe awa 48 gasịrị - 10 mg nke Lisinopril. Mgbe ahụ, ọgwụ a bụ 10 mg 1 oge kwa ụbọchị.

Ekwesịrị inye ndị ọrịa nwere obere ọbara mgbagha ọbara (≤ 120 mm Hg) obere ọgwụgwọ ọgwụgwọ nke Lisinopril, 2.5 mg, tupu ịmalite ọgwụgwọ ma ọ bụ n'ime ụbọchị 3 mbụ mgbe obi ọgụ gasịrị.

Ekwesịrị ịga n'ihu maka ọgwụgwọ maka izu isii. Uzo eji edozi ugwọ ya bu 10 mg kwa ubochi. A na-atụ aro ndị ọrịa nwere mgbaàmà nke nkụda obi ka ha gaa n’ihu na Lisinopril.

Njirimara nke iji ahazi akwara

Ebe ọ bụ na mkpochapu lisinopril bụ site na akụrụ, usoro izizi na-adabere na nhichapụ nke creatinine, usoro mmezi na-adabere na nzaghachi ụlọ ọgwụ, a na-ahọrọ ya na nlele mgbe niile gbasara ọrụ gbasara akụrụ, potassium serum na sodium.

Mkpochapu nke creatinine (ml / min)

Oge Dose (mg / ụbọchị)

3 g / ụbọchị, nwere ike belata mmetụta hypotensive nke ACF inhibitors. Ojiji NSAIDs na ACF na-egbochi n'otu oge nwere ike ibute hyperkalemia, nke na-emetụta ọrụ ọrụ na-adịghị mma. Mmetụta a na-agbanwegharị ọzọ, na ngosipụta ya ga - ekwe omume, nke mbụ, na ndị ọrịa nwere nkwarụ na-efe efe gara aga. Ekwesịrị iji nlezianya dekọta ihe ndị na - egbochi ACF na NSAIDs, ọkachasị ndị agadi ma ọ bụ ndị mmiri gwụrụ. Ndị ọrịa kwesịrị inwe mmiri dị mma, mgbe ọ gbasasịrị ọgwụ, ọ dị mkpa iji nyochaa ọrụ akụrụ.

Mgbe enyere ACF inhibitors na nhazi ọla edo dị ka injections (dịka ọmụmaatụ sodium aurothiomalate), mmeghachi nke nitrate (mgbaàmà vasodilation, gụnyere nsị, ọgbụgbọ, ọgbụgbọ na hypotension, nke nwere ike ịdị oke njọ mgbe ụfọdụ) nwere ike ịmalite mgbe niile.

Ojiji nke oge ọgwụ ndị ọzọ na - egbochi ihe ọkụkụ nwere ike ịbawanye ike nke lisinopril. Ofnwekọta njikọta nke lisinopril na nitroglycerin, nitrates ndị ọzọ, ma ọ bụ vasodilators ndị ọzọ nwere ike ime ka ọbara mgbali elu belata.

Iji kpachara anya, jiri ọgwụ mgbochi lisinopril mee ihe n'otu oge, iji ọgwụ mgbochi, tricyclic antidepressants na antipsychotics na ndị na - egbochi ACF n'ihi mmụba bara ụba.

Sympathomimetics nwere ike belata mmetụta hypotensive nke ACF inhibitors.

Iji ọgwụ Lisinopril na ọgwụ mgbochi ọrịa (insulin, ọgwụ hypoglycemic nke ọgwụ) eme ihe

Jiri ike hypoglycemia mee ka mmetụta hypoglycemic nke ndị ikpeazụ sie ike. Mmetụta a nwere ike yie n'ime izu ndị mbụ nke ọgwụgwọ njikọta na ndị ọrịa nwere ọdịda akụrụ.

Enwere ike iji Lisinopril mee ihe n'otu oge na acetylsalicylic acid (na usoro iji nye mmetụta antiplatelet), thrombolytics, beta-blockers na / ma ọ bụ nitrates.

Ntụziaka pụrụ iche

Pmmepeakwara ozihypotension ọ ga - ekwe omume na ndị ọrịa nwere hyponatremia na / ma ọ bụ belata olu nke na - ekesa ọbara n'ihi ọgwụgwọ nke ịba ọcha n'anya, iji nri ndị pụrụ iche ma ọ bụ nkụda mmụọ nke anụ ahụ maka ihe ndị ọzọ (ị sweụbiga ọuseụ, ọgbụgbọ ugboro ugboro, afọ ọsịsa, mmịpụta) yana obi ike. Ọgwụ hypotension nwere ezumike ụra ma, ọ bụrụ na ọ dị mkpa, ọgwụ infusion. Mbelata nke ọbara mgbali elu abụghị mgbochi maka ọgwụgwọ na Lisinopril, agbanyeghị, enwere ike ịchọ ịkwụsị ọgwụ ahụ ma ọ bụ mbelata dose ka ọ ga-achọ.

Ọgwụ ọgwụgwọ na Lisinopril ga-ebido tupu izizi nke mmiri elektrolyte na mkpochapu ụkọ olu ọbara, na mgbakwunye, ileba anya na mgbanwe mgbanwe obara ọbara mgbe ị afterụchara ọgwụ mbụ dị mkpa.

Na ọrịa cerebrovaskụla na ọrịa obi, ọ kwesịrị iburu n'uche na mbelata ọbara mgbali elu nwere ike ibute mmepe nke ọrịa strok ma ọ bụ infarction myocardial.

Na nnukwu myocardial infarction a na-atụ aro ịgwọ ọrịa na lisinopril ka ebido n’ime ndị ọrịa nwere ihe mgbaàmà nke nsogbu gbasara akụrụ, nke a na-ekpebisi ike n’otu ihe mgbakwunye serum creatinine nke dị elu karịa 177 μmol / L na / ma ọ bụ proteinuria karịrị 500 mg / 24 h. 265 μmol / l), mgbe ahụ iwepụ ya dị mkpa.

Ọrịa na lisinopril bụ contraindicated na ikpe kadiogenic ujo ya na nnukwu myocardial infarctionọ bụrụ na nhọpụta nke vasodilator nwere ike belata hemodynamics, dịka ọmụmaatụ, mgbe nrụgide systolic anaghị agafe 100 mm Hg

Site na nrụgide systolic nke na-erughị 120 mm Hg, a na-enye doses nke Lisinopril dị ala n'ime ụbọchị 3 mbụ nke infarction myocardial - 2.5 mg / ụbọchị. Site na hypotension arterial, a na-ebelata ihe ndozi ka 5 mg / ụbọchị ma ọ bụ nwa oge na 2.5 mg / ụbọchị. Site na hypotension toro ogologo, yana nrụgide systolic n'okpuru 90 mm Hg, a na-akagbu ọgwụ ahụ.

Narenal artery tenosis (bilateral ma ọ bụ otu na otuakụrụ)

N'ime ụfọdụ ndị ọrịa nwere akwara mkpụrụ ndụ akwara ma ọ bụ stenosis nke otu akụrụ akwara, ịta urea na creatinine n'ọbara ọbara na-abawanye, nke, dịka iwu, tụgharịrị mgbe ọ kwụsịrị ọgwụgwọ, mgbe enyere Lisinopril iwu. Nke a bụ ihe karikarị na ndị ọrịa nwere ọdịda akụrụ.

NaỌrịa nkwarụ ọbara enwere ọghọm nke ibute ọrịa akwara na ọdịda akwara. N'ime ndị ọrịa a, ekwesịrị ịmalite ọgwụgwọ na lisinopril n'okpuru nlekọta ahụike siri ike na obere usoro onyonyo, na-esochi titition.

Aortic, mitral valve stenosis, hypertrophic cardiomyopathy

Dịka ndị ọzọ ACF inhibitors, ekwesịrị iji lisinopril jiri nlezianya mee ihe na ndị ọrịa nwere mitral valve stenosis, valvụ valve valve, ma ọ bụ cardioyopathy hypertrophic.

Ọrịa Angioedema dị ụkọ n'ebe ndị ọrịa na-anabata ndị na-egbochi ACF. N'ụdị ndị dị otu a, ekwesịrị ịkwụsị ọgwụ ahụ ozugbo yana ekwesịrị ịnye ọgwụ kwesiri ekwesi ruo mgbe ekpochapu akara ọrịa edema kpamkpam.

N'ihe banyere nnukwu ịwa ahụ ma ọ bụ nke ọgwụ nwere mmetụta na-adịghị ala ala, Lisinopril na-egbochi ntụgharị nke renin ka angiotensin-II. Hypotension, nke nwere ike ịbụ nsonaazụ nke usoro dị n'elu, enwere ike iwepụ ya site na itinyeghachi olu nke ọbara na-ekesa.

Ahụ ike/ LDLọgwụ egbugbere ọnụ / ọgwụ ụkwara ume ọkụ

Site na nhazi oge nke Lisinopril na mmetọ nke nwere mpempe polyacryl-nitrile ma ọ bụ LDL (obere njupụta lipoprotein) na ntụpọ dextran ma ọ bụ desensitization megide nsị ahụhụ (a beesụ, beps), ujo anaphylactic nwere ike ịmalite.

A na-atụ aro ka ị jiri akpụkpọ ahụ mebiri emebi ma ọ bụ jiri ọgwụ ọgwụ antihypertensive ọzọ (ọ bụghị ACF inhibitors) dochie Lisinopril.

Tupu enweghị nchekasị, ekwesịrị ịkwụsị lisinopril.

A na-ahụta Neutropenia, agranulocytosis, thrombocytopenia na anaemia n'ọnọdụ ndị adịkarịghị njọ na ndị ọrịa na-anata ndị na-egbochi ACF. Ihe ịtụnanya ndị a bụ ndị agbanwere mgbe ha kwụsịrị Lisinopril. Ekwesịrị iji ọgwụ ahụ mee ihe na oke ịkpachapụ anya na ndị ọrịa nwere ọrịa autoimmune na-anata immunosuppressants, allopurinol, ma ọ bụ procainamide. Mgbe ị na-eji lisinopril eme ihe na ndị ọrịa dị otú a, a na-atụ aro maka ilele ọkwa nke leukocytes n'ọbara.

Ndihe nketaayanabataghiụkọ galactose Lapp lactase,galadsorption syndrome - galactose

Ekwesighi inye ọgwụ nke Lisinopril ka ndị ọrịa na-enwetachaghị mmachi galactose ekweghị ibe nọrọ, Lapp lactase erughi ma ọ bụ ọrịa nke ịnakwere glucose na-akpata - galactose n'ihi ọnụnọ nke lactose monohydrate na ihe mejupụtara ya.

Akụkụ nke nsonaazụ ọgwụ ahụ nwere ike ịnya ụgbọ ma ọ bụ usoro nwere ike ibute

Mgbe ị na-ewere Lisinopril, a naghị atụ aro ịkwọ ụgbọala ma rụọ ọrụ nwere ike ịbụ ihe egwu, n'ihi mmepe nke mmeghachi omume ojoo (ọgbụgba).

Dodoụbiga ya ókè

Ọrịa nnukwu hypotension ruo na steeti ujo, hyperkalemia, bradycardia, tachycardia, mkpụmkpụ ume, ọdịda akụrụ, ụkwara, anya ntughari, nchekasị.

Ọgwụgwọ: gastric lavage, oriri nke adsorbents na sodium sulfate mgbe ewerechara mbadamba Lisinopril n'ime. Okwesiri ijikwa nguzozi nke mmiri-electrolyte na serum creatinine.

Ejiri usoro ọgwụgwọ Symptomatic, nchịkwa intravenous nke 0.9% sodium chloride solution, ndị na-ahụ maka agrenergic nwere nnukwu hypotension. Na bradycardia, a na-ejikwa atropine, ma ọ bụrụ na ọ dị mkpa, enwere ike ịtụle nrụnye pacemaker. Lisinopril buputara ya na mpaghara anakpo ya.

Mwepụta wepụtara na nkwakọ

Na mbadamba 10 na ngwungwu na-acha ọrịre sitere na fim nke polyvinyl chloride na foil aluminom.

Mpempe akwụkwọ 3, 5 yana ntuziaka akwadoro maka ojiji ahụike na steeti na asụsụ Russian ka etinye na ngwugwu kaadiboodu.

Oghere eji eme ọnya mbata (na-enweghị mgbakwunye na otu kaadiboodu) etinye n'ime igbe kaadiboodu. Dabere na ọnụ ọgụgụ nke ngwugwu ahụ, a na-etinye ntuziaka maka ojiji ahụike na steeti na asụsụ Russian n'ime igbe ọ bụla.