Cefepim - ntuziaka maka ojiji, analogues, nyocha na ụdị mwepụta (injections na ampoules maka injections nke ọgwụ nje kwa 1 gram, mbadamba) ọgwụ maka ọgwụgwọ nke bronchi, ponia, cystitis na ndị okenye, ụmụaka na ime.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Cefepim. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara ojiji ọgwụ nje cefepime na-eme. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Analogs nke oge nchere n'ihu ọnụnọ analogues dị n'ụdị nhazi. Jiri maka ọgwụgwọ nke bronchi, oyi baa, cystitis na ọrịa ndị ọzọ na-efe efe na ndị okenye, ụmụaka, yana n’oge ime na lactation. Ngwakọta ọgwụ ahụ.

Cefepim - ọgwụ mgbochi cephalosporin sitere na ọgbọ nke anọ maka ojiji nke parenteral. Ọ nwere mmetụta nje na-akpata, na-akpaghasị njikọ nke mgbidi sel nke microorganisms.

Na-arụ ọrụ megide ọtụtụ nje bacteria na-adịghị mma, gụnyere. na-emepụta beta-lactamases, gụnyere Pseudomonas aeruginosa. Arụ ọrụ karịa cephalosporins ọgbọ atọ, megide cocci gram-gram-gram.

Ọ naghị arụ ọrụ megide Enterococcus spp. (enterococcus), Listeria spp. (Listeria), Legionella spp. (Legionella), ụfọdụ nje anaerobic (Bacteroides fragilis, Clostridium difficile).

Ihe e ji mara Cepepime bụ nnukwu nkwụsi ike megide plasmid dị iche iche na beta-lactamases chromosomal.

Ngwakọta

Cefepima hydrochloride + ndị na-arụ ọrụ.

Mlọ ọgwụ

Njikọ protin plasma erughị pasent 19% ma ọ nọọrọ onwe ya na itinye onwe ya na oge ịche ọkwa. A na - achọta ọgwụgwọ oge nke oge ana - eme ka mmamịrị, bile, mmiri nke mmiri, na - eme ka ọnya na - agbaze ume, na - emegharị ahụ, ihe na - adịghị ala ala, ọnya afọ na ọnya afọ, mmiri mkpụrụ akụkụ yana meningitis. N'ime ahụike ndị mmadụ, ya na nchịkwa intravenous nke cefepime na dose nke 2 g na nkeji nke 8 awa 9 ụbọchị, enweghị ntụpọ n’ahụ. Oge akụrụ ji emee emepe emepe emepe, ọkachasị bụ site na nnomi na-akpụkọ (nzipu mkpụkọ ezumike - 110 ml / min). N'ime mmamịrị ahụ, ihe dị ka 85% nke oge awa a na-elekọta na-ahụghị agbanwe. N'ime ndị ọrịa dị afọ iri isii na ise ma ọ bụ karịa nwee ọrụ mkpo nkịtị, ikike ikpochapụ obere dị na ndị ọrịa na-eto eto. A na-agbanwe ọgwụ ọgwụ nke oge anwụrụ na ndị ọrịa nwere ọrụ umeji, cystic fibrosis anaghị agbanwe.

Ihe na-egosi

Ọgwụgwọ ọrịa na-efe efe na mkpali kpatara microfeganisms-na-emetụtakarị:

Ọrịa akụkụ nke akụkụ okuku ume na ala (gụnyere oyi baa na ụkwara ume ọkụ),
urinary tract na-efe efe (ma ihe mgbagwoju anya ma na-agbakọbeghị),
ọrịa akpụkpọ ahụ na anụ ahụ dị nro,
intra-abdominal na-efe efe (gụnyere peritonitis na biliary tract na-efe efe),
ọrịa gynecological
ọrịa mbufụt
eriri afọ neutropenic (dika ọgwụ ọgwụ),
ọrịa nje meningitis na ụmụaka.

Mgbochi ọrịa n’arụ n’afọ.

Dị Mwepụta

Ntụ ntụ maka nkwadebe nke ihe ngwọta maka nchịkwa mgbochi intramuscular nke 1 gram (injections in ampoules for injection).

Formsdị usoro ọgwụgwọ ọzọ, ma ọ bụ mbadamba ma ọ bụ okpu.

Ntụziaka maka ojiji na usoro onunu ogwu

Onwe, dabere na uche nke pathogen, ogo ọrịa ahụ, yana steeti gbasara ọrụ.

A na-ahọrọ ụzọ nchịkwa n'ime ọbara maka ndị ọrịa nwere ọrịa na-egbu egbu ma ọ bụ nke na-egbu ndụ, ọkachasị na ihe oke ụjọ.

Site na nchịkwa intramuscular ma ọ bụ nchịkwa nke ndị okenye na ụmụaka na-ebu ihe karịrị 40 n'arọ nwere ọrụ gbasara ọrụ nkịtị, otu ụzọ bụ 0-1-1 g, etiti oge dị n'etiti nchịkwa bụ awa 12. Maka ọrịa siri ike, a na-achịkwa ya mgbe a na - etinye 2 2 kwa awa 12 ọ bụla.

Iji gbochie ọrịa n'oge ịwa ahụ, a na-eji ha na metronidazole dịka atụmatụ ahụ si dị.

Maka umuaka site na onwa abuo, onwa kwesiri kariri karia ihe eji akwadoro maka ndi okenye. Ọkara dịnụ maka ụmụaka na-eru 40 kilogram na ọrịa ọrịa urinary na-emetụta ma ọ bụ na-enweghị nsogbu (gụnyere pyelonephritis), ọrịa na-adịghị agbanwe agbanwe nke anụ ahụ na anụ ahụ dị nro, oyi baa, na ọgwụgwọ ahụ ọkụ na-arịa oke ọkụ bụ 50 mg / kg kwa awa 12.

Ndị ọrịa nwere ọkụ ọgbụgba na meningitis nje - 50 mg / n'arọ kwa elekere asatọ.

Ogologo oge ọgwụgwọ bụ 7-10 ụbọchị. Na nnukwu ọrịa, enwere ike ịchọ ọgwụgwọ ogologo oge.

N'ọnọdụ arụ ọrụ ezumike mkpirikpi (CC erughị 30 ml / min), mgbazi nke usoro usoro usoro ọgwụgwọ ahụ dị mkpa. Oge izizi nke oge ezumike kwesịrị ịbụ otu maka ndị ọrịa nwere ọrụ ezumike nkịtị. A na-ekpebi usoro mmezi na-adabere n'ụkpụrụ nke QC ma ọ bụ nlebara ogige nke creatinine.

Site na ịba ọcha n'anya n'ime awa 3, ihe dị ka 68% nke ngụkọta oge a na - ewepụ anụ ahụ n'ime ahụ. Na ngwụsị nke nnọkọ ọ bụla, ọ dị mkpa iwebata ọgwụ ugboro ugboro na ọnụọgụ mbụ. N’ebe ndị ọrịa na-aga n’ihu n’ịgwọ ọrịa ambulatory peritoneal, a pụrụ iji ogefefe gboo gboo aro, i.e. 500 mg, 1 g ma ọ bụ 2 g, dabere n'ịdị ọcha nke ọrịa ahụ, na etiti oge dị n'etiti nchịkwa nke otu ọgwụ were awa 48

Maka ụmụaka nwere nsogbu gbasara akụrụngwa, a na-atụ aro otu mgbanwe ahụ na usoro onunu ogwu ka ọ dị maka ndị okenye, ebe ọ bụ na ọgwụ ọgwụ nke oge ọmụmụ na ndị okenye na ụmụaka yiri.

Mmetụta akụkụ

afọ ọsịsa, afọ ntachi,
ọgbụgbọ, vomiting,
colitis (gụnyere ọrịa pịudomembranous colitis),
mgbu afọ
uto mgbanwe
ihe nwu
itching
urticaria
mmeghachi omume anaphylactic,
isi ọwụwa
anya ntughari
paresthesia
ogwe
acha uhie uhie
anaemia
ụba ọrụ nke AlT, AST, alkaline phosphatase,
mmụba na bilirubin,
eosinophilia, thrombocytopenia nke na-adị obere oge, leukopenia na neutropenia,
mmụba na oge prothrombin,
nyocha nke Coombs dị mma na-enweghị hemolysis,
ahụ ọkụ
vaginitis
erythema
akụkụ itching
candidiasis akpọghị,
phlebitis (ya na nchịkwa intravenous),
site na nchịkwa intramuscular, mbufụt ma ọ bụ ihe mgbu na ebe a na-agba agba ọ ga-ekwe omume.

Ihe ngbanwe

hypersensitivity na cefepime ma ọ bụ L-arginine, yana ọgwụ mgbochi cephalosporin, penicillins ma ọ bụ ọgwụ beta-lactam ndị ọzọ.

Ime na lactation

Emebeghi omumu ihe omimi na nchedo nke nchekwa oge obula n’oge omumu, ihe a ga - ekwe omume dobe ya n’aka onye dibia.

A na-apịpụta mmiri ara ehi n'oge mmiri ara ara. N'oge ị na-asa ahụ, jiri nlezianya kpachara anya.

Na nyocha nnwale, ọ nweghị nsonaazụ omumu omumu na fetotoxic nke oge ana - ekpughe.

Jiri na umuaka

Emebeghi nchekwa na arụmọrụ nke oge mmiri na ụmụaka gbara ọnwa abụọ. Maka ụmụaka ruru ọnwa abụọ (gụnyere ụmụ ọhụrụ), iji ya ga-ekwe omume dabere na usoro usoro onunu ogwu. Maka ụmụaka nwere nsogbu gbasara akụrụngwa, a na-atụ aro otu mgbanwe ahụ na usoro onunu ogwu ka ọ dị maka ndị okenye, ebe ọ bụ na ọgwụ ọgwụ nke oge ọmụmụ na ndị okenye na ụmụaka yiri.

Ntụziaka pụrụ iche

Mgbe ejiri ya na ndị ọrịa nọ n'ihe egwu dị elu nke ọrịa n'ihi mbufụt aerobic / anaerobic microflora (gụnyere n'ọnọdụ ebe Bacteroides fragilis bụ otu n'ime nje), a na-atụ aro ịkọ ọgwụ na-arụ ọrụ megide Cefepim n'otu oge na pathogen. anaerobes.

Jiri ịkpachara anya mee ka ndị ọrịa nọrọ n'ihe ize ndụ nke ịmaliteghachi mmeghachi omume nfụkasị, karịsịa ọgwụ.

Site na mmepe nke mmeghachi omume nfụkasị ahụ, ekwesịrị ịkwụsị ịkwụsị oge mmiri.

N’ozi mmeghachi omume ozugbo, epinephrine (adrenaline) na ụdị nkwado ndị ọzọ nwere ike ịchọ.

Mgbe afọ ọsịsa malitere n'oge ọgwụgwọ, a ga-atụle ohere nke pseudomembranous colitis. N'ụdị ndị ahụ, ekwesịrị iwepụ oge elekere ozugbo ma ekwesịrị ịkọwa ọgwụgwọ kwesịrị ekwesị ma ọ bụrụ na ọ dị mkpa.

Site na mmepe nke superinfection, ekwesịrị ịkagbu Cefepim ozugbo yana usoro ọgwụgwọ kwesịrị ekwesị.

Mgbe ị na-eji ọgwụ nje ndị ọzọ nke cephalosporin otu, urticaria, Stevens-Johnson syndrome, erythema multiforme, na-egbu egbu epicmal necrolysis, colitis, ọrụ mkpịsị akwara, nephropathy mmiri, ọbara ọgbụgba, ọbara ọgbụgba, ọbara ọgbụgba, nkwarụ, ọrụ imeju na-akpata, gụnyere cholestasis, nsonaazụ ụgha. glukor glucose.

Site na nlekọta pụrụ iche, a na-eji cefepime yana aminoglycosides na "loop" diuretics.

Mkparịta ụka ọgwụ ọjọọ

Site na nhazi nke oge a na-enwe usoro elekere na ngwọta nke metronidazole, vancomycin, gentamicin, tobramycin sulfate na netilmicin sulfate, mmekọrịta mmekọrịta ọgwụ ga-ekwe omume.

Analogues nke ọgwụ Cefepim

Anakpụrụ nke analogues nke na-arụ ọrụ: