Vasotens® (Vasotens®)

Doto angiotensin II nnabata antagonist (subtype AT1)
Nkwadebe: VAZOTENZ®

Ọrụ umi nke ogwu: losartan
Ihe nzuzo ATX: C09CA01
KFG: Onye anakpo Angiotensin II
Nọmba ndebanye: LS-002340
Ofbọchị idebanye aha: 12/08/06
Ndi nwe reg. acc.: ACTAVIS hf.

Releasedị Vazotens tọhapụrụ, nchịkọta ọgwụ na ihe mejupụtara.

Mbadamba ụrọ a na-acha ọcha gbara okirikiri, biconvex, akara “3L” n'otu akụkụ, nwere ihe egwu n'akụkụ abụọ yana ihe egwu dị n'akụkụ. Taabụ 1 losartan potassium 50 mg
Ndị ọkachamara: mannitol, celclose microcrystalline, ssumum croscarmellose, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.
Mbadamba ụrọ a na-acha ọcha bụ oval, biconvex, nke akpọrọ “4L” n'otu akụkụ. Taabụ 1 losartan potassium 100 mg
Ndị ọkachamara: mannitol, celclose microcrystalline, ssumum croscarmellose, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Ngwakọta na ụdị ntọhapụ

na pịọdụ pensụl 7., na ngwungwu kaadiboodu 2 blisters.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu - mbadamba mkpuchi nwere:

• 12.5 mg: okirikiri, akụkụ abụọ, na-acha ọcha, akara “1L” n'otu akụkụ,
• 25 mg: okirikiri, akụkụ abụọ, na-acha ọcha, akara “2L” n'otu akụkụ,
• 50 mg: okirikiri, akụkụ abụọ, na-acha ọcha, nke nwere ọghọm ya na ihe ọghọm n'akụkụ ya abụọ, akara nke “3” na “L” n'akụkụ abụọ nke ihe ize ndụ ahụ,
• 100 mg: oval, convex n'akụkụ abụọ, na-acha ọcha, na enweghị akara n'otu akụkụ yana akara "4L" n'akụkụ nke ọzọ, na-enwe ihe ọghọm n'akụkụ.

Mkpokọta mbadamba: 7 pcs. na ngwungwu ogbe, na ngwungwu nke 2 ma obu 4 blisters, 10 PC. na ngwungwu ogbe, na ngwungwu nke blisters 1 ma obu 3, pcs iri na anọ. na ọnya, na ngwungwu nke 1 ma ọ bụ abụọ nke blisters. Nke ọ bụla bukwara ntuziaka maka ojiji nke vazotenza.

Nri arụ ọrụ: losartan potassium, na mbadamba 1 - 12.5 mg, 25 mg, 50 mg ma ọ bụ 100 mg.

Ngwa inye aka: microcrystalline cellulose, hypromellose 6, povidone K-30, croscarmellose sodium, mannitol, magnesium stearate, propylene glycol, talc, titanium dioxide (E171).

Nkọwa nke ụdị usoro onunu ogwu

Mbadamba 50 mg: mbadamba biconvex gbara okirikiri, na-acha ọcha, nke a kpuchiri ekpuchi, na iji ya edepụta akụkụ nke "3L", nwere ihe egwu n'akụkụ abụọ yana ihe egwu dị n'akụkụ.

Mbadamba mbadamba 100: Mpempe biconvex oval, na-acha ọcha, nke a kpuchiri ekpuchi, ya na iji ya mee ihe n'otu akụkụ "4L"

Mlọ ọgwụ

Losartan bụ onye na - emegidekarị ihe nnabata nke angiotensin II, bụ nke AT subtype₁. Kinase II (enzyme bradykinin na-emebi emebi) anaghị egbochi.

Isi mmetụta nke losartan:

• belata na ngụkọta akwara na - emetụta mkpụkọ, uche nke aldosterone na adrenaline n'ọbara, ọbara ọgbụgba, mgbali n'ọbara.
• ebidolata mbelata
• mmetụta diuretic
• igbochi mmepe nke hypertrophy myocardial,
• mụbara mgbatị mmega ahụ n'etiti nkụda obi.

Vasotens na-egosipụta mmetụta hypotensive mgbe otu ọgwụ (gosipụtara dị ka mbelata systolic na nrụgide diastolic), na-erute oke mgbe awa 6 gasịrị, mmetụta ahụ jiri nwayọọ nwayọọ belata karịa awa 24.

Mmetụta hypotensive kachasị nke vasotenza na-amalite izu 3-6 mgbe mmalite nke nchịkwa.

Mlọ ọgwụ

Losartan na-abanye ngwa ngwa site na eriri afọ. Bioavailability dị ihe dịka 33%. Ndi_max (oge iji rute ịta uru nke ihe ahụ) - nkeji 60.

Losartan na-enweta nsonaazụ nke akụkụ mbụ site na imeju, metabolism na-eme site na carboxylation na ntinye nke CYP2C9 isoenzyme, etolite metabolite na-arụ ọrụ. Ndi_max metabolite nọ n'ọrụ - awa 3-4, ogo nke jikọtara ya na protein protein plasma - 99%.

Ndi_1/2 (ọkara ndụ) nke ihe dị na ya site na awa 1.5 ruo elekere abụọ, isi metabolite ya bụ awa isii. Ihe dị ka 35% nke ọgwụ a na-apụ apụ na mmamịrị, site na eriri afọ - ihe dịka 60%.

Site na imeju nke imeju, mkpụkọ Plasma nke losartan na-abawanye nke ukwuu.

Vazotens, ntuziaka maka ojiji: usoro na usoro onunu ogwu

Ekwesịrị iburu mbadamba mkpụrụ osisi Vazotens 1 otu ụbọchị kwa ụbọchị (agbanyeghị ọgwụ enyere). Oge nri adịghị mkpa.

Usoro ọgwụgwọ usoro ọkọlọtọ maka vasotenza:

• ọbara ọgbụgba: akwara ịgwọ ọrịa bụ 50 mg, iji rụpụta nsonaazụ ka ukwuu, ọ ga - ekwe omume ịbawanye ọgwụ ahụ na 100 mg, ma ọ bụrụ na ọ dị mkpa, enwere ike kee mkpụrụ ọgwụ kwa ụbọchị ụzọ abụọ. Ọgwụ nke mbụ maka ndị ọrịa na-anata ọgwụ ụkwara ume ọkụ dị ukwuu bụ 25 mg.
• nkụchi obi: ọgwụ mbido bụ 12.5 mg, mgbe ahụ ọ na-abawanye na etiti oge nke izu 1, nke mbụ ruo 25 mg, emesia ruo 50 mg. Nkezi ihe mmezi bụ 50 mg.

N'ihe dị ala, vasotens ka enyere ndị ọrịa nwere nsogbu imeju na-arụ ọrụ, gụnyere ọrịa cirrhosis.

Nsonaazụ

N'ọtụtụ oge, a na-anabata vasotens nke ọma, mmeghachi omume na-emebi emebi na-apụtakarị na ọdịdị ahụ anaghị achọ ịkwụsị ọgwụgwọ.

Effects nwere ike inwe mmetụta ọjọọ:

• sitere na akwara obi: orthostatic hypotension (dependant dose), palpitations, arrhythmias, bradycardia, tachycardia, angina pectoris,
• site na sistem ụjọ: ọtụtụ mgbe (≥ 1%) - nkụchi, ike ọgwụgwụ, asthenia, nsogbu ehighị ụra, isi ọwụwa, adịkarịghị (

Ime na lactation

Enweghị data maka iji losartan n'oge afọ ime. Agbanyeghị, ịmara na ọgwụ na-emetụta sistemụ renin-angiotensin, mgbe ejiri ya na nke abụọ na nke atọ nke afọ ime, nwere ike ibute nkwarụ mmepe ma ọ bụ ọbụna ọnwụ nke nwa ebu n’afọ. Yabụ, ọ bụrụ na ime adị, a ga-akwụsị Vazotenza ® ozugbo.

Mgbe etinyere ya n’oge a na-enye nwa ara, o kwesịrị ime mkpebi iji kwụsị inye ya ara ma ọ bụ ịkwụsị ọgwụgwọ ya na Vazotens ®.

Mmekorita

Enwere ike inye gị ọgwụ ndị ọzọ na - ere ọgwụ na - ere ọkụ.

Enweghị mmekọrịta dị egwu na hydrochlorothiazide, digoxin, anticoagulants na-apụtaghị ìhè, cimetidine, phenobarbital.

N'ime ndị ọrịa akpịrị na-agba mmiri (tupu iji ọgwụ ọrịa buru ibu), enwere mbelata ọbara mgbali elu.

Na-eme ka mmụba (jikọtara ọnụ) mmetụta nke ọgwụ ndị ọzọ na - egbochi ọgwụ (diuretics, beta-blockers, sympatholytics).

Na-abawanye n'ihe ize ndụ nke hyperkalemia mgbe ejiri ya na ọgwụ mkpịsị ọkụ na potassium.

Usoro onunu ogwu na nhazi

N'ime n'agbanyeghị nri. Otutu maka ntinye - oge 1 kwa ụbọchị.

Site n'ọbara mgbali elu, nkezi kwa ụbọchị bụ 50 mg. N'ọnọdụ ụfọdụ, iji nweta nsonaazụ ka ukwuu, a na-amụba dose ahụ ruo 100 mg na usoro onyonyo abụọ ma ọ bụ 1 oge kwa ụbọchị.

Ọgwụ nke mbụ maka ndị ọrịa nwere nkụda mmụọ bụ 12.5 mg otu ugboro n'ụbọchị. Dịka iwu, a na-abawanye ọgwụ ahụ na etiti izu (i.e. 12.5, 25 na 50 mg / ụbọchị) na nlekọta mmezi nke 50 mg otu ugboro kwa ụbọchị, dabere na ndidi onye ọgwụ a.

Mgbe ị na-edepụta ọgwụ ahụ nye ndị ọrịa na-anara diuretics na oke ọnụọgụ, ọgwụ mbụ Vazotens ® kwesịrị belata 25 mg otu ugboro n'ụbọchị.

Ekwesịrị inye ndị ọrịa nwere nsogbu imeju nwere obere Vazotenza ses.

N'ime ndị ọrịa agadi, yana ndị ọrịa nwere nsogbu gbasara akụrụngwa, gụnyere ndị ọrịa na usoro ọgwụgwọ, ọ nweghị mkpa ịhazigharị usoro mbụ.

Ojiji ụmụaka

Emebebeghị nchekwa na ịdị mma nke ọgwụ a na ụmụaka.

Ntụziaka pụrụ iche

Ọ dị mkpa iji dozie akpịrị ịkpọ nkụ tupu i dee ọgwụ Vazotens ® ma ọ bụ ịmalite ọgwụgwọ site na iji ọgwụ ahụ na obere ala.

Ọgwụ ndị na-emetụta sistemụ renin-angiotensin nwere ike ime ka urea ọbara na pine creatinine dị na ndị ọrịa nwere nsogbu akwara ma ọ bụ nke akụrụ.

N'oge ọgwụgwọ, a ga-enyocha ike itinye mkpụrụ nke potassium n'ime ọbara oge niile, ọkachasị ndị ọrịa merela agadi, ndị nwere nsogbu ọrụ mkpo ya.

Ndụ shelf nke ọgwụ Vazotens ®

Mbadamba ụrọ mkpuchi 12.5 mg - 3 afọ.

Mbadamba ụrọ mkpuchi 12.5 mg - 3 afọ.

Mbadamba mbadamba 25 mg - 3 afọ.

Mbadamba mbadamba 25 mg - 3 afọ.

Mbadamba mbadamba 50 mg - 3 afọ.

Mbadamba mbadamba 50 mg - 3 afọ.

Mbadamba ụrọ mkpuchi 100 mg - afọ 3.

Mbadamba ụrọ mkpuchi 100 mg - afọ 3.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Eme ọgwụ ọgwụ nke vasotens

Doto angiotensin II nnabata antagonist (subtype AT1). Ọ na-egbochi kinase II, enzyme nke na-akụda bradykinin. Na-ebelata OPSS, itinye uche na ọbara nke adrenaline na aldosterone, ọbara mgbali, nrụgide na mgbasa akwara. Na -ebelata mbubata ibu, nwere mmetụta diuretic. Na-egbochi mmepe nke hypertrophy myocardial, na-eme ka ndidi na-eme ka ndị ọrịa nwee nkụda mmụọ.
Mgbe otu ọ bụla, mmetụta hypotensive (systolic na diastolic ọbara mgbali agbadata) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24.
Mmetụta hypotensive kachasị na-enweta izu 3-6 mgbe mmalite ọgwụ.

Vazotens: ọnụ ahịa dị na ụlọ ahịa ọgwụ dị n'ịntanetị

Vazotens 12.5 mg mbadamba mbadamba 30 pcs.

Vazotens 50 mg mbadamba ihe nkiri 30 pcs.

VAZOTENZ 50mg 30 PC. mbadamba mkpuchi

Vazotens taabụ. PO 50mg n30

Vazotens taabụ. PO 100mg n30

Vazotens 100 mg mbadamba ihe nkiri 30 pcs.

VAZOTENZ 100mg 30 PC. mbadamba mkpuchi

VAZOTENZ N 100mg + 25mg 30 PC. mbadamba ihe mkpuchi

Mmụta: Mahadum Ahụike Rostov State, ọpụrụiche "General Medicine".

A na - emejupụta ozi gbasara ọgwụ ahụ, enyere ya aka ka ọ nweta ihe ọ bụla, ọ naghị edochi ntuziaka gọọmentị. Medication medicationụ onwe gị ọgwụ dị ize ndụ nye ahụ ike!

Iji kwuo ọbụna okwu kachasị mkpụmkpụ ma dị mfe, anyị na-eji akwara iri abụọ na asaa.

Ndị mmadụ na-eri nri ụtụtụ mgbe niile yikarịrị ka hà buru oke ibu.

Onye gụrụ akwụkwọ adịkarịghị arịa ọrịa ụbụrụ. Ọrụ ọgụgụ isi na-enye aka n'ịmepụta anụ ahụ ndị ọzọ iji kwụọ ndị ọrịa ọrịa.

Ndị dọkịta ezé apụtawo n'oge na-adịbeghị anya. Laa azụ na narị afọ nke 19, ọ bụ ọrụ dịịrị onye na-edozi isi nkịtị iji wepụ ezé na-arịa ọrịa.

Ọ bụrụ na imeju gị kwụsịrị ịrụ ọrụ, ọnwụ ga-apụta n'ime otu ụbọchị.

Dabere na ọtụtụ ndị ọkà mmụta sayensị, usoro ihe ọmụmụ vitamin abaghị uru ụmụ mmadụ.

N'oge ndụ, nkezi onye na-amịpụta obere mmiri mmiri abụọ.

Dabere na ọnụ ọgụgụ, na ụbọchị Mọnde, ihe ize ndụ nke mmerụ azụ na-abawanye site na 25%, yana ihe ọghọm nke nkụchi obi - site na 33%. Kpachara anya.

Dabere na nyocha nke WHO, mkparịta ụka kwa ụbọchị na ekwentị na-eme ka ohere nke ịmalite ụbụrụ dị 40% nwee ohere.

Ọ bụrụ na ị na-amụmụ ọnụ ọchị naanị ugboro abụọ n'ụbọchị, ịnwere ike belata ọbara mgbali ma belata ihe egwu nkụchi na ọnya afọ.

Nkezi afọ nke lefties erughị righties.

Enwere syndrom ọgwụ na-adọrọ mmasị dị ukwuu, dị ka ị inụ mmiri na-emetụta oke. N'ime afọ nke otu onye ọrịa na-arịa ọrịa a, achọpụtara ihe ndị ala ọzọ dị narị abụọ.

Mpekere chọkọleti anọ gbara ọchịchịrị nwere ihe dị ka calorie narị abụọ. Yabụ ọ bụrụ na ịchọghị ịka mma, ọ ka mma ịghara iri karịa lobules abụọ kwa ụbọchị.

Ọrụ mmadụ na-enweghị mmasị na ya bụ ihe na-emebi mmụọ ya karịa enweghị ọrụ ma ọlị.

Ọkpụkpụ mmadụ siri ike karịa okpukpu anọ.

Oge izizi nke okooko osisi na-abịa na njedebe, mana ahịhịa ga-anọchi ahịhịa site na mbido June, nke ga-akpaghasị ndị na-arịa ya.

Usoro onunu ogwu na uzo icho ogwu a.

A na-ewere ọgwụ ahụ ọnụ, n'agbanyeghị nri, ugboro ole nchịkwa - 1 oge / ụbọchị.
Site n'ọbara mgbali elu, nkezi kwa ụbọchị bụ 50 mg. N'ọnọdụ ụfọdụ, iji nweta nsonaazụ ka ukwuu, a na-amụba dose ahụ ruo 100 mg na usoro onyonyo abụọ ma ọ bụ 1 oge / ụbọchị.
Mgbe ị na-edepụta ọgwụ ahụ maka ndị ọrịa na-anata diuretics na oke onunu ogwu, ọgwụ mbu Vazotens kwesịrị belata na 25 mg 1 oge / ụbọchị.
Ọgwụ nke mbụ maka ndị ọrịa nwere nkụchi obi bụ 12.5 mg 1 oge / ụbọchị. Dịka iwu, ọnụọgụ ahụ na-abawanye site na etiti izu (i.e. 12.5 mg / ụbọchị, 25 mg / ụbọchị na 50 mg / ụbọchị) na nkezi mmezi nke 50 mg 1 oge / ụbọchị, dabere na ndidi.
Ekwesịrị ka e nye ndị ọrịa nwere nsogbu imeju (gụnyere ọrịa cirrhosis) obere ọgwụ vasotenz.
N'ime ndị ọrịa agadi, yana ndị ọrịa nwere ọrụ gbasara akụrụngwa, gụnyere ndị ọrịa na usoro ọgwụgwọ, ọ nweghị mkpa ịhazigharị usoro mbụ.