Ciprofloxacin-AKOS Ciprofloxacin

Anya na-agbada 0.3% n'ụdị nke ihe doro anya nke agba odo na-acha odo odo ma ọ bụ na-acha akwụkwọ ndụ akwụkwọ ndụ.

Ndị pụrụ iche: nnu nke disodium nke ethylenediaminetetraacetic acid, mannitol ma obu mannitol, sodium acetate anhydrous ma obu mmiri ato, glacial acetic acid, benzalkonium chloride, mmiri d / na.

5 ml - karama panpa polyethylene (1) - ngwugwu nke kaadiboodu.

Mpempe usoro onunu ogwu

Anya gbadara 0.3%

1 ml nke ihe ngwọta nwere

ike - ciprofloxacin hydrochloride (na usoro nke ciprofloxacin) - 3 mg,

ndị mbụ: benzalkonium chloride - 0.10 mg, disodium ededate (nnu disodium nke ethylenediaminetetraacetic acid, Trilon B), mannitol (mannitol), sodium acetate trihydrate (sodium acetic acid 3-aqueous), glactic acetic acid, mmiri maka injection.

Ngwọta doro anya dịtụ edo edo ma ọ bụ ubé na-acha akwụkwọ ndụ akwụkwọ ndụ

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe etinyere ya n’elu, ciprofloxacin na-abanye nke ọma na akwara nke anya. Ọ na-abanye na cornea na ihu ihu nke anya, ọkachasị mgbe mkpọchi epithelial nke cornea na-agbagha. Na mbibi nkuku, ịta nri nke ciprofloxacin na ya dị irè megide ọtụtụ ndị na - ebutekarị ọrịa na-efe efe.

Mgbe otu nkuzi, ịka ciprofloxacin na mmiri nke oghere ihu ahụ ruru ka nkeji iri ma ọ bụrụ 100 μg / ml. Oke kachasị nke Cmax na mmiri nke ulo ihu mgbe 1 elekere bụ 190 μg / ml. Mgbe awa 2 gachara, ịta ọgwụ ahụ malitere ịbelata, ebe ọgwụ mgbochi ya na akwara nke cornea na-ewe awa 6, na mmiri nke ụlọ ihu - ruo awa anọ.

Mgbe instillation, systemic ọgwụ nke ọgwụ ga-ekwe omume. Na ntinye ngwa anya nke anya uto nke ciprofloxacin 4 ugboro / ubochi ma anya gi rue ubochi asaa, ntughari nke ciprofloxacin na plasma obara erughi 2-2.5 ng / ml, ntinye uche kacha karia 5 ng / ml. Mgbe etinyere n’elu, T1 / 2 sitere na plasma bụ awa 4-5. Ọgwụ ahụ na-amịpụta akụrụ na-agbanweghi agbanwe - ruru 50%, na ụdị metabolites - ruru 10%, site na eriri afọ - ihe dịka 15%. Refọdụ n'ime ọgwụ ahụ na-apụ apụ na mmiri ara.

Mlọ ọgwụ

Onye na - ahụ maka ọgwụ nje na - ahụ maka ngwa agha site na otu fluoroquinolones (ihe dị n'okpuru nke monofluoroquinolones) maka iji ọgwụ na ọgwụ ophthalmology.

Na-egbochi nje gy kokoro nke nje (topoisomerases II na IV, na-ahụ maka usoro nke ịchịkwa DNA chromosomal gburugburu nuklia RNA, nke dị mkpa maka ịgụ mkpụrụ ndụ ihe nketa), na-akpaghasị njikọ DNA, uto nje na nkewa, na-akpata mgbanwe mgbanwe morphological (gụnyere mgbidi sel na membranes) na ọnwụ ngwa ngwa nke mkpụrụ ndụ nje.

Ọ na - eme nje bacteria na - egbu ihe n'ahụ gram n'oge ezumike na nkewa (ebe ọ na - emetụta ọ bụghị naanị DNA gyrase, kamakwa ọ na - akpata lysis nke cell cell), na microorganisms gram-positive naanị naanị n'oge nkewa. Na-abawanye ike nke mgbidi nje ahụ.

A na-akọwara ntakịrị mmerụ ahụ maka mkpụrụ ndụ macroorganism site na enweghị DNA gyrase n'ime ha. Mgbe ị na-a ciụ ọgwụ ciprofloxacin, enweghi mmepe nke yiri nke iguzogide ọgwụ ndị ọzọ na - esiteghị na otu nke ndị na - egbochi gyring inhibitors, nke a na - eme ka ọ dị oke mma megide nje ndị na - eguzogide aminoglycosides, penicillins, cephalosporins, tetracyclines na ọtụtụ ọgwụ nje ndị ọzọ.

Nnọọ mmetụta na ciprofloxacin: nje gram-ọjọọ aerobic: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii. Yersinia spp.), Ndi ozo gram ọjọọ nje (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), ọrịa nje intracellular ụfọdụ - Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium ụkwara nta, Mycobacterium kansasii, Corynebacterium diphtheriae,

Mkpụrụ ọgwụ nje a na-ahụ anya nke ọma: Staphylococcus spp.(Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).

Imirikiti methicillin na-eguzogide staphylococci na-eguzogide ọgwụ na ciprofloxacin.

Ihe mmetụta Ọrịa oyiboptoptoccus, Enterococcus faecalis, avcococoium Mycobacterium (dị na intracellularly) - na - agafeghị oke (a chọrọ nnukwu itinye aka na njide ha).

Emegide ọgwụ: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Enweghị ike megide Treponema pallidum.

Nguzogide na ciprofloxacin na-amalite nwayọ nwayọ, n'ihi na, n'otu aka ahụ, mgbe ọrụ nke ciprofloxacin enwechaghị microorganisms, na aka nke ọzọ, mkpụrụ ndụ nje enweghị enzyme na-egbochi ya. Ọgwụ dị ala na-egbu egbu.

Ihe ngosi maka ojiji

Ọrịa anya anya na-efe efe nke microorganisms chere na ọgwụ ahụ:

- nnukwu na subacute conjunctivitis

- ọnya na-arịa ọnya afọ

- ọnya ọnya na-efe efe mgbe mmerụ ahụ ma ọ bụ ahụ ndị si mba ọzọ

Mgbochi na ọgwụgwọ nke ọrịa na-efe efe na mmerụ nke anya na ngwa ya (gụnyere mgbe ewepụchara anụ ahụ si na cornea, conjunctiva, mgbe ekpughere kemịkal ma ọ bụ n'ụzọ anụ ahụ) na n'oge arụmọrụ na nku anya (tupu mgbochi ọrịa nje na ịwa ahụ na ịwa ahụ ophthalmic).

Ofzọ nke ngwana onunu ogwu

N'obodo 1-2 dobe n’ime akpa nke njikọ anya. Ugboro nke nrụnye dabere na ogo usoro mmekpa ahụ.

Ọ bụrụ na ọrịa dị nwayọ ruo obere oge, a na-etinye 1-2 tụlee n'ime njikọ nke anya anya emetụtara (ma ọ bụ anya abụọ) n'ime awa anọ ọ bụla, na nnukwu ọrịa, 2 na-agbadata kwa awa. Mgbe ọ rụchara ọrụ, a na-ebelata dose na ugboro ole nrụnye.

Na ọrịa nje conjunctivitis, dị mfe, scaly na ọnya afọ - 4-8 ugboro / ụbọchị, dabere na ogo usoro mbufụt.

Na keratitis - 1 dobe opekata mpe 6 / ụbọchị.

N'ihi mbibi cornea nke Pseudomonas aeruginosa kpatara, 1 dobe ma ọ dịkarịa ala ugboro 8-12 / ụbọchị.

N'ihe mgbu uveitis n'ihu, a na-enye ọgwụ ọgwụ 1 dobe ugboro 8-12 ugboro / ụbọchị. Na nnukwu dacryocystitis na canaliculitis - 1 dobe 6-12 ugboro / ụbọchị, na-adịghị ala ala - 4-8 ugboro / ụbọchị.

N'ihe banyere ọnya ọnya afọ: n’ụbọchị mbụ - kwa minit 15 ọ bụla ruo awa 6, wee daa 1 nkeji ọ bụla n’ime awa iri atọ ọ bụla, ụbọchị nke abụọ - 1 na-adaba n’oge awa ọ bụla n’oge awa ọ bụla, site na ụbọchị 3 ruo 14 - 1 dobe kwa ụbọchị 4 awa mgbe awa.

Maka mgbochi nke ọrịa nke abụọ na mmerụ nke anya na ngwa ya - 1 dobe ugboro 4-8 / ụbọchị maka izu 1-2. Maka mgbochi nke ọrịa oria mgbe a wachara ya ahụ na idogharị anya - 1 dobe ugboro isii na isii / ụbọchi oge ọ bụla.

Oge ojiji. Ogologo oge ọgwụgwọ na-adabere n'ịdị ọcha nke ọrịa ahụ, usoro ọgwụgwọ na nsonaazụ nke ọmụmụ nje.

Nsonaazụ

- mmeghachi omume nfụkasị, nro dị nro na hyperemia ọgbụgbọ

- mba ọzọ ahuhu n'anya

- oke uto na onu ozugbo instillation

- belata na anya acuity

- nputa nke akpukpo oku di ọcha n’aru ndi oria isi oria

ntụpọ ma ọ bụ akụkụ ọgbụgba

Mkparịta ụka ọgwụ ọjọọ

Mkparịta ụka ọgwụ: ngwọta nkeproprololoxacin ekwekọghị na ọgwụ ọgwụ nke nwere uru pH nke 3-4, nke enweghị arụ ma ọ bụ nke kemịkal.

Na ntinye ọnụ na ọgwụ nje ndị ọzọ, a na-ahụkarị njikọta mmekọrịta (ọgwụ mgbochi beta-lactam, aminoglycosides, clindamycin, metronidazole).

Ntụziaka pụrụ iche

Iji nlezianya: Edere ọgwụ a maka ndị ọrịa nwere ọrịa arteriosclerosis, ihe mberede ụbụrụ, ọrịa nkwarụ.

Ngwọta n'ụdị nsị nke anya abụghị ka eji ya gbue ya.

Enweghi ike inye ọgwụ ahụ subconjunctival ma ọ bụ banye n'ime ihu ihu nke anya.

Mgbe ị na-eji ọgwụ ophthalmic ndị ọzọ, etiti oge dị na nchịkwa ha kwesịrị ịbụ opekata mpe 5.

Ọ bụrụ na, mgbe itesịrị ntanye, hyperemia njikọta na-aga n'ihu ma ọ bụ na-abawanye ogologo oge, mgbe ahụ ịkwesịrị ịkwụsị ị andụ ọgwụ ahụ ma kpọtụrụ dọkịta.

Ciprofloxacin-AKOS anya mmiri nwere ihe eji egbochi mkpụrụ ndụ klọọkụịja nke benzalkonium, nke nwere ike ibute iwe iwe na oghere mwepu dị nro. Yabụ, tupu ị Ciụ ọgwụ Ciprofloxacin-AKOS, onye ọrịa ahụ kwesịrị iwepu oghere kọntaktị ma tinye ya naanị mgbe nkeji iri na ise gachara.

Akụkụ nke nsonaazụ ọgwụ ahụ nwere ike ịnya ụgbọ ma ọ bụ usoro nwere ike ibute

Ndị ọrịa ọrịa furu efu ụzọ ya nwa oge ka etinyere ya n'ọrụ ka akwadoghị ịkwọ ụgbọ ala ma ọ bụ rụọ igwe, igwe ma ọ bụ akụrụngwa ọ bụla nwere ọkaibe nke chọrọ ezigbo ọhụụ ozugbo ịtọla ọgwụ ahụ.

Mwepụta wepụtara na nkwakọ

Anya gbadara 0.3%.

5 ml na karama maka anya mmiri na -emepụta na a na-eme ka a jupụta ya na okpu mkpuchi si na rọba.

5 ml na karama eji eme ihe eji eme ihe na okpu mkpuchi ya na okpu eji ebu ihe. A na-etinye otu vidiyo ya na ntuziaka maka ojiji ahụike na steeti na asụsụ Russian n'ime mkpọ kaadiboodu

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Ciprofloxacin-AKOS dị ka ọfụma doro anya na obere odo na-acha odo odo ma ọ bụ nke akwụkwọ ndụ akwụkwọ ndụ. Ọgwụ dị na arịa dị milimita 5, nke ọ bụla nwere dropper.

Nkwadebe a nwere ihe ndia:

• ciprofloxacin hydrochloride - ihe bụ isi, 3 mg na 1 ml nke ihe ngwọta,
• anhydrous ma ọ bụ 3-aqueous sodium acetate, acetic acid, mannitol, wdg (nchịkọta ndị ọzọ).

Ibepu anya bu oria ogwu - fluoroquinolones, ihe ngbochu oria. A na-etinye vial ọ bụla na ọgwụ ọgwụ n'ime obere igbe, tinyere ntuziaka na iwu ojiji.

Ihe ngbanwe

Ntụziaka maka akụkọ eji eme ihe: a na - egbochi ọgwụ ọgwụ n'ihu ọnụọgụ nke keratitis, mmebi nke anya na akụkụ ahụ. Ngwọta ahụ ekwesịghị iji ndị nwere nnu na ose na ihe mejupụtara ya.

N'iji nlezianya kachasi ike, edere ndị ọrịa nwere nsogbu dịka ụbụrụ arteriosclerosis, ụdọ, na mgbasa ụbụrụ na-ezighi ezi.

Usoro onunu ogwu na nhazi

A na-agbanye ngwá ọrụ ahụ n'ime obere njikọ nke anya. A na-eji ọgwụ ahụ eme ihe dịka ndụmọdụ ndị a:

1. Maka ọrịa dị nro ma ọ bụ agafeghị oke - 1-2 gbadara ya na oge awa anọ.
2. Site na ọrịa nwere mgbagwoju anya, 2 na-agbadata kwa awa.

Usoro onunu ogwu ya na oge ochichi ya ji ebelata ka ihe mgbaàmà ya belatara. Ọ bụ dọkịta na-edoziri oge ọgwụgwọ ahụ iche iche. Ná nkezi, ọgwụgwọ dị ruo izu 1-2.

Ojiji nke itufu oge ime na lactation

Na agbanyeghi eziokwu na ntinye anya nke anya n’iru na-abanye ihe mgbochi placental wee banye n’ime mmiri ara, ka enwere ike nye onye di ime ma obu onye na-enye nwa ara ogwu. A ga-eji ihe ga-eme ka nsogbu a dị mma na-aestụ ara ma ọ bụ na-enye nwa ara naanị mgbe ejiri nlezianya tụlechaa nsonaazụ niile nke nsonaazụ yana mwepu ha.

Nsonaazụ

Mmetụta ndị na-etolite n'oge a na-eji Ciprofloxacin-AKOS na-egosipụtakarị site na mmeghachi omume mpaghara:

• itching
• na-ere ọkụ
• obere ihe mgbu
• mmekọrịta hyperemia,
• afufu nke eyelids,
• lacrimation
• keratitis
• keratopathy
• nguzobe nke ọdiri,
• inyocha onwe
• mmetụta nke ọnụnọ na nku anya nke ihe mba ọzọ.

Ozugbo etinyere ụdọ aka, ngwaụụ na-adịghị mma nke dị n'ọnụ nwere ike apụta, ọganiihu nwa oge n'ọrụ ọrụ. N'ime ọnọdụ ọjọọ nke sistemụ na ndị ọrịa na-eji fluoroquinolone a, a na-edekọ ọgbụgba.

Ọ bụrụ na hyperemia conjunctival na-enwe nchegbu mgbe niile megide mmalite nke ojiji anya anya, ị ,ụ ọgwụ ahụ kwesịrị ịkwụsị ma gakwuru dọkịta gị.

Releasedị ntọhapụ ngwaahịa, ihe mejupụtara na nkwakọ

A na-eme ọpịpị mkpụrụ anya Ciprofloxacin-Akos n'ụdị nke nnweta anya doro anya nke akwụkwọ ndụ akwụkwọ ndụ na-acha odo odo ma ọ bụ nke odo.

Otu mililita nwere miligrams nke ciprofloxacin (n'ụdị hydrochloride). Ihe ndị a na-eso dị ka ihe inyeaka: nnu nke disodium nke ethylenediaminetetraacetic acid, d / a mmiri, mannitol ma ọ bụ mannitol, benzalkonium chloride, glacial acetic acid, sodium acetate, anhydrous ma ọ bụ anhydrous.

Mpempe aka mgbapu bu karama panye nke polyethylene ise na ngwugwu kaadiboodu.

Atụmatụ Ọgwụ

Dịka ntuziaka ahụ si dị, Ciprofloxacin-Akos bụ onye na-ahụ maka ọgwụ mgbochi, ọgwụ nje fluoroquinolone. Ọ na-arụ ọrụ ahụhụ. Ọ na-egbochi nje gy DNA nke nje (topoisomerases IV na nke abụọ, nke a na-ahụ maka ihe na-eme na chromosomal supercoiling n'akụkụ nuklia RNA, nke a dị mkpa maka ịgụta ozi eketa eketa), na-akpaghasị njikọ nke DNA, nkewapụta nje na uto, na-akpata mgbanwe mgbanwe morphological (gụnyere membranes na cell mgbidi) yana mbibi ọsọ ọsọ nke mkpụrụ ndụ nje.

Ọ bactericidal megide microorganisms gram-na-adịghị mma n'oge nkewa na dormancy (ebe ọ na-emetụta ọ bụghị naanị DNA gyrase, kamakwa na-akpalite lysis nke cell cell), gram-microorganisms gram-naanị na usoro nke nkewa.

Enwere ike ịkọwa nsị na mkpụrụ ndụ macroorganism site na enweghị mkpịsị DNA dị na ha.

N'otu oge ahụ, megide ndabere nke ciprofloxacin, mmepụta ihe nke iguzogide ọgwụ ndị ọzọ na-abụghị gyrase inhibitors anaghị eme, nke na-eme ka ọgwụ ahụ dị oke mma megide nje ndị na-eguzogide, dịka ọmụmaatụ, na tetracyclines, cephalosporins, penicillins, peninoillins, aminoglycosides na ọgwụ nje ndị ọzọ.

Imirikiti staphylococci bụ ndị na-eguzogide methicillin na-eguzogide ọgwụ na ciprofloxacin. Nguzogide nke pathogens nwere mmetụta na-amalite nwayọ nwayọ, ebe ọ bụ na, n'otu aka, enwere obere microorganisms na-adịgide mgbe mmetụta nke ciprofloxacin, n'aka nke ọzọ, enweghi enzymes na mkpụrụ ndụ nke na-egbochi ya.

Ihe ngosi na contraindications

Ejiri "Ciprofloxacin-Akos" maka:

• subacute na nnukwu conjunctivitis,
• propeslaxis nke ọrịa ịwa ahụ na-efe efe,
• blepharoconjunctivitis, ịba ọcha n'anya,
• nsia na-efe efe nke akụkụ ahụ nke ọhụụ site na mgbe ọgbụgba nke ihe ndị mba ọzọ ma ọ bụ mmerụ ahụ,
• keratoconjunctivitis, keratitis,
• meibomite
• dacryocystitis na-adịghị ala ala
• ọnya afọ nke ụdị nje a.

• ya na oria keratitis,
• ya na uche ya na ihe mejupụtara ngwaahịa a
• ụmụ na-erubeghị otu afọ.

Akwụkwọ ntuziaka

A na-eji “Ciprofloxacin-Akos” eme ihe na mpaghara, site na igbanye ha n'ime akwa njikọ. Ọ bụrụ na onye ọrịa ahụ nwere ọrịa anya na-adịghị ala, dịkwa nfe, ọ ga-etinye mmiri otu ma ọ bụ abụọ n'ime anya emetụtara kwa awa anọ. Ọ bụrụ na ọrịa ahụ siri ike, mgbe ahụ instillation a na-eme kwa awa abụọ. A na-ebelata ojiji a na-ejikarị ya eme ihe mgbe ọnọdụ ahụ na-akawanye mma. Usoro ọgwụgwọ ahụ na-ewe otu izu ma izu abụọ.

Site na ọnya nje

Ojiji nke “Ciprofloxacin-Akos” bụrụ na ọnya ọnya nje: ụbọchị mbụ - dobe kwa elekere kwa elekere maka awa isii, mgbe ahụ kwa ọkara elekere na-agbada ruo ụra abalị, n'ụbọchị nke abụọ - jiri otu elekere wee si n'ụtụtụ ruo n'abalị. n'ụbọchị nke atọ nke iri na anọ - awa anọ ọ bụla dị na anya, dobe site na dobe. Ọ bụrụ na ọnya ahụ adịghị agwọ ọnya, enwere ike ịga n'ihu na usoro ọgwụgwọ ahụ.

Ọ dị mkpa imechi karama mgbe ejiri ya. A machibidoro iji mmetụ pipette emetụ anya.

Usoro ahịa ọgwụ ahịa

Russian Federation, 640008, Kurgan, Constitutionkpụrụ Iwu, 7.

tel / faksị (3522) 48-16-89

Mpempe akwụkwọ Mpempe akwụkwọ

Synthesis OJSC, Russia

Adreesị nke nzukọ ahụ nke na-anabata ndị na-azụ ahịa banyere ụdị ngwaahịa dị n'ókèala nke Republic of Kazakhstan ma bụrụ onye na-ahụ maka nyochaa ndebanye nke nchekwa ọgwụ na ókèala Republic of Kazakhstan.

Deсalog LLP, 050050, Republic of Kazakhstan,

Omume ọgwụ

Onye na - ahụ maka ọgwụ nje na - ahụ maka ngwa agha site na otu fluoroquinolones (ihe dị n'okpuru nke monofluoroquinolones) maka iji ọgwụ na ọgwụ ophthalmology. Ọ na - eme ka ọnya mmadụ nọ na - egbochi ihe njiri dị na DNA (topoisomerases II na IV, na - ahụ maka nnabata nke chromosomal DNA gburugburu nuklia RG, nke dị mkpa maka ịgụ mkpụrụ ndụ ihe), na - akpaghasị njikọ nke DNA, uto nje na nkewa, na - akpata mgbanwe mgbanwe morphological (gụnyere mgbidi sel na membranes) na ọnwụ ngwa ngwa nke mkpụrụ ndụ nje.

Ọ na - eme nje bacteria na - egbu ihe n'ahụ gram n'oge ezumike na nkewa (ebe ọ na - emetụta ọ bụghị naanị DNA gyrase, kamakwa ọ na - akpata lysis nke cell cell), na microorganisms gram-positive naanị naanị n'oge nkewa. Na-abawanye ike nke mgbidi nje ahụ.

Mgbe ị na-a ciụ ọgwụ ciprofloxacin, enweghi mmepe nke yiri nke iguzogide ọgwụ ndị ọzọ na - esiteghị na otu nke ndị na - egbochi gyring inhibitors, nke a na - eme ka ọ dị oke mma megide nje ndị na - eguzogide aminoglycosides, penicillins, cephalosporins, tetracyclines na ọtụtụ ọgwụ nje ndị ọzọ.

Ciprofloxacin nwere invitro ọrụ megide a dịgasị iche iche nke gram-nti na gram-ọjọọ microorganisms. A na-ebute ihe ndị na-akpata ahụhụ ahụ nke ciprofloxacin site na igosipụta na enzyme DNA gyrase, nke dị mkpa maka njikọ nke DNA nke microorganisms. Achọpụtara na ciprofloxacin nwere mmetụta na-arụ ọrụ dị ka invitro megide ọtụtụ ụdị microorganism ndị a:

Ọkpụkpọ dị mma:

• Staphylococcus aureus (nke gụnyere methicillin-sensena na methicillin na-egbochi nsogbu), epropimidis Staphylococcus, pulonia, Streptococcus pneumoniae, Streptococcus (otu nje virus).

Gram-ọjọọ:

• Haemophilus influenzae, Pseudomonas aeruginosa, Serratia marcescens.

Nnyocha ọmụmụ egosila na ciprofloxacin na-arụ ọrụ megide ọtụtụ ụdị microorganisms ndị na-esote, ọ bụ ezie amatabeghị mkpa ọmarịcha data a.

Ọkpụkpọ dị mma:

• Enterococcusfaecalis (ọtụtụ ụdị nwere ntakịrị mmetụta na-adịghị ala ala), Staphylococcushaemolyticus, Staphylococccushominis, Staphylococcussaprophytics, Staphylococcuspyogenes.

Gram-ọjọọ:

• Acinetobacter calcoaceticus subsp. anitratus, Aeromonas caviae, Aeromonas hydrophila, Brucella melitensis, Campylobacter coli, Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Edwardsiella tarda, Enterobacter aerogenes, Enterobacter cloacaeli, Escherichoi Moraxella (Branhamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Salmonella fibrero, Shigella fibrene , Yersinia enterocolitica.

Microorganisms ndị ọzọ:

• Chlamydia trachomatis (naanị na-enwe ike ịrịa ọrịa) na ụkwara nta Mycobacterium (naanị nwere ike ịnwe obere oge).

Ọtụtụ nsogbu Pseudomonas cepacia na ụfọdụ ụdị nke Pseudomonas maltophilia na-eguzogide ciprofloxacin, dị ka ọtụtụ nje anaerobic, gụnyere Bacteroides fragilis na Clostridium difficile.

Nguzogide vitro ciprofloxacin na-amalitekarị nwayọ nwayọ (mmụkọ ọtụtụ).

Usoro usoro onunu ogwu

Usoro akwadoro maka ịgwọ ọnya afọ bụ dịka ndị a:

• abụọ ga-adị n ’anya ọnya a nkeji iri na ise n’ime elekere isii izizi, wee daa abụọ n’ anya ọnya n’ime minit iri atọ n’ime oge fọdụrụ n’ụbọchị mbụ. N’ụbọchị nke abụọ, kụọ abụọ n ’anya ọnya na-awa kwa elekere. N’ụbọchị nke atọ na ruo ụbọchị iri na anọ, gbanye mmiri abụọ n’ime anya ọnya kwa awa anọ. Ọ bụrụ na ụbọchị 14 ka e mechara ọgwụgwọ ahụ, ejikọtaghachi azụ nke corneal emebeghị, enwere ike ịga n'ihu na ọgwụgwọ ahụ.

Usoro ọgwụgwọ akwadoro maka nje conjunctivitis:

• otu ma ọ bụ abụọ na-etinye n’ime akpa / akpa akpa n’oge awa abụọ ọ bụla n’ime ụbọchị mbụ. N’ụbọchị ise sochirinụ, otu ma ọ bụ abụọ daa n’awa anọ ọ bụla.

Ogologo oge ọgwụgwọ maka ọrịa ọ bụla bụ ụbọchị 21.

Mkparịta ụka ọgwụ ọjọọ

Enweghi omumu puru iche na nmekorita nke ciprofloxacin nke nwere anya anya ya na ogwu ndi ozo. Ka osiladi, usoro iji ụfọdụ quinolones butere mmụba nke mkpokọ ogwu na plasma, ihe na-ebute metabolism nke caffeine, na mmụba na arụmọrụ ọgwụ, warfarin na usoro ya. Achọpụtatịrị ịrị elu na-emetụta mkpụrụ osisi creatinine ma ọ bụrụ na onye ọrịa ahụ na-ewere cyclosporine n'otu oge.

Ọ bụrụ na ebumnuche iji ọgwụ ọgwụ ophthalmic ndị ọzọ, ekwesịrị ịkesa ojiji ha ka oge na-aga site na nkeji iri na ise.

Ọgwụ nwere ihe dị ize ndụ nwere ike ịgbatị oge maka QT:

A ga-eji Ciprofloxacin, dị ka fluoroquinolones ndị ọzọ, na-akpachara anya na ndị ọrịa na-enweta ọgwụ nwere ihe ize ndụ a ma ama maka ịgbatị oge QT (dịka ọmụmaatụ, klas IA na III antiarrhythmic ọgwụ, tricyclic antidepressants, macrolides, antipsychotics.

Mkpọtụrụ anya

Ọ bụ ihe amamihe dị na ya iyi akwa lenals dị nro n'oge ọgwụgwọ ọgwụ. Ọ bụrụ na a na-eji lenses siri ike, mgbe ahụ ịkwesịrị iwepu ha tupu usoro ahụ ma gbanye ya ọzọ na nkeji 15-20 mgbe nchịkwa ọgwụ gasịrị.

Mmetụta ikike ndị ọrịa nwere ịchịkwa usoro na ịkwọ ụgbọ: ndị mmadụ tụfuru doo anya nke ọhụụ mgbe ejiri Ciprofloxacin-Akos anaghị ekwe ka arụ ọrụ na igwe, akụrụngwa ma ọ bụ igwe, ma ọ bụ kwọọ ụgbọ, ebe ọ bụ na achọrọ nghọta nke ọhụụ ozugbo usoro.

Ọnọdụ nchekwa na ndụ nchekwa

Ekwesịrị ịchekwa mmiri nje na ebe a na-echebe ya site na ọkụ, na-enwe ọnọdụ okpomọkụ nke +15 ruo +25 Celsius. Ọgwụ ekwesịghị oyi. Ekwesịrị ịgụnye ohere ị nweta ọgwụ maka ụmụaka na ụmụ anụmanụ bi n'ụlọ.

Ndụ nchekwa nke ọgwụ ophthalmic na vial a kachitere bụ afọ 2. Mgbe emepere akpa ahụ ọgwụ ahụ, ekwesịrị iji ọdịnaya ya mee ihe maka ebumnuche ya ụbọchị 28.

Iji dochie ngwaahịa mbụ ahụ, ihe ndị a na-emetụta:

• Athenoxine.
• Betaciprol.
• Vero-Ciprofloxacin.
• Ciprinol.
• Microflox.
• Nkeji.
• Oftocipro.
• Nircip.

Ngwaahịa ndị edepụtara ahaziri na azịza akọwara, nwere ihe jikọtara ọnụ, ihe ọgwụgwọ na njiri mara maka ojiji. A na-enwetakwa ọgwụ ndị yiri ya n'ụdị nke anya anya ma eme ha.

Ciprofloxacin-AKOS bụ ọgwụ na-akwụ ụgwọ dị ala nke na-enyere aka ịlụ ọgụ n'ọtụtụ ọrịa anya. Ọgwụ nwere ọnụ ahịa ọnụ ala, nke sitere na 23-36 rubles A na-ere ya n'ụlọ ahịa ọgwụ na ọgwụ edenye ya. Tupu iji ngwa a, ọ dị mkpa iji nyochaa nyocha nke ophthalmic ma nweta ọgwụ dọkịta.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, 0.25 g 2-3 ugboro n'ụbọchị, yana nnukwu ọrịa - 0,5-0.75 g 2-3 ugboro n'ụbọchị.

N'ihe banyere ọrịa urinary tract - 0.25-0.5 g 2 ugboro n'ụbọchị, usoro ọgwụgwọ - 7-10 ụbọchị.

Site na akwara ọgbụgba na - agbakọ - 0.25-0.5 g otu oge, yana njikọta ọrịa gonococcal na chlamydial na mycoplasma - 0.75 g kwa awa 12 ọ bụla maka ụbọchị 7-10.

Na chancroid - 0,5 g ugboro abụọ n'ụbọchị ọtụtụ ụbọchị.

Site na iji ụgbọ meningococcal na nasopharynx - otu ugboro, 0,5 ma ọ bụ 0.75 g.

N'ime ụgbọ ala Salmonella na-adịghị ala ala, site na ọnụ, 0.25 g ugboro anọ 4, usoro ọgwụgwọ ahụ ruru izu anọ. Ọ bụrụ na ọ dị mkpa, a ga-amụba usoro ahụ ka ọ bụrụ 0,5 g ugboro atọ n'ụbọchị.

Site na oyi baa, osteomyelitis - n'ime, 0.75 g ugboro abụọ n'ụbọchị. Ogologo oge ọgwụgwọ osteomyelitis nwere ike ịdị ọnwa 2.

Maka ọrịa gastrointestinal nke Staphylococcus aureus kpatara, 0.75 g kwa awa 12 ọ bụla maka ụbọchị 7-28.

Ọ ga-aga n'ihu n'ọgwụgwọ ọ dịkarịa ala ụbọchị 3 mgbe emesịrị ịcha ahụ ma ọ bụ mgbaàmà nke mgbaàmà ọrịa.

N'ụwa nnwale zuru ụwa ọnụ (CC 31-60 ml / min / 1.73 sq.m ma ọ bụ ihe nlebara anya site na 1.4 ruo 1.9 mg / 100 ml), ihe kachasị ubochi kwa ụbọchị bụ 1 g. N'ụba nnomi zuru ụwa ọnụ n'okpuru 30 ml / min / 1.73 sq. m ma ọ bụ uche nke mejupụtara ihe nlere dị elu karịa 2 mg / 100 ml; dose kwa ụbọchị - 0,5 g.

Ọ bụrụ na onye ọrịa ahụ na-arịa hemodialysis ma ọ bụ mgbawa peritoneal - 0.25-0.5 g / ụbọchị, mana ekwesịrị ị takenụ ọgwụ ahụ mgbe oge hemodialysis gasịrị.

Na ọrịa dị egwu (dịka ọmụmaatụ, ụbụrụ cystic fibrosis ugboro ugboro, ọrịa nke eriri afọ, ọkpụkpụ na nkwonkwo) nke Pseudomonas ma ọ bụ staphylococci, ọria na-efe efe nke sitere na Streptococcus pneumoniae, na ọrịa chlamydial nke ọnya mkpụrụ ndụ, ekwesịrị ịbawanye ọgwụ ahụ ruo 0.75 g kwa awa iri na abụọ.

Kwesịrị iji mmiri dị obere rie obere mbadamba nkume ahụ ma ha rie nri. Mgbe ị na-a theụ ọgwụ na afọ efu, a na-etinye ihe dị n'ọrụ ngwa ngwa.

Ntinye nfuli: oge ​​ọgbụgba bụ nkeji iri atọ na nkeji 0.2 g na nkeji iri isii na ọkara nke 0.4 g. Ngwọta infusion, dị njikere iji, enwere ike ijikọ ya na 0.9% NaCl solution, Ringer na Ringer-lactate, 5 na 10% ngwọta. dextrose, 10% fructose ngwọta, yana otu ihe ngwọta nke nwere dextrose 5% na 0.225-0.45% NaCl.

Site na ọrịa urinary na-enweghị nsogbu, obere akpa ume na-efe efe, otu mmachi bụ 0.2 g, yana ọrịa nje na - emetụta ngụgụ nke elu urinary, yana ọrịa siri ike (gụnyere oyi baa, osteomyelitis), otu ọgwụ bụ 0.4 g. Ọ bụrụ na ọ dị mkpa, / na ọgwụgwọ nke ọrịa siri ike, nke na - egbu egbu ma ọ bụ na - ebutekarị ọrịa nke Pseudomonas, staphylococci ma ọ bụ Streptococcus pneumoniae, enwere ike ịbawanye ọnụọgụ ahụ ruo 0.4 g na ugboro nchịkwa ruo ugboro 3 kwa ụbọchị. Ogologo oge ọgwụgwọ maka osteomyelitis nwere ike iru ọnwa 2.

Riagegbọelu Salmonella adịghị ala ala - 0.2 g ugboro abụọ n ’ụbọchị a na - eme ya ọgwụgwọ - rue izu anọ. Ọ bụrụ na ọ dị mkpa, a ga-amụba usoro ahụ ka ọ bụrụ 0,5 g ugboro atọ n'ụbọchị.

Na nnukwu gonorrhea - 0.1 g otu ugboro.

Maka mgbochi nke ibute ọrịa n’oge usoro ịwa ahụ - 0.2-0.4 g maka awa 0,5-1 tupu arụ ọrụ, na oge ịwa ahụ gafere karịa awa anọ, na-ejikwa otu ọgwụ ahụ.

Ogologo oge ọgwụgwọ: ụbọchị 1 - na nnukwu ọgbụgba akwara na -akpata ọnya ọgbụgba na cystitis, ruo ụbọchị asaa - na ọrịa nke akụrụ, akwara na oghere afọ, na oge niile nke oge neutropenic - na ndị ọrịa nwere ahụ esighi ike, ma ọ bụghị ihe karịrị ọnwa 2 - osteomyelitis na ụbọchị 7-14 - yana ọrịa ndị ọzọ niile. Site na ọrịa nje streptococcal n'ihi ihe egwu nke ndagwurugwu, yana ọrịa chlamydial, ọgwụgwọ kwesịrị ịdịkarịa ala ụbọchị 10. N'ime ndị ọrịa nwere oke immunodeficiency, a na-eme ọgwụgwọ n'oge oge niile nke neutropenia.

Ekwesịrị ịgwọ ya tupu ọ dịkarịa ala ụbọchị 3 mgbe emesịrị ịcha ahụ ma ọ bụ mgbaàmà nke mgbaàmà ọrịa.

N'ụwa nzacha ọnụ zuru ụwa ọnụ (CC 31-60 ml / min / 1.73 sq.m ma ọ bụ mkpụrụ osisi mejupụtara nke 1.4 ruo 1.9 mg / 100 ml), kacha sọha ụbọchị bụ 0.8 g.

N'ụwa nzacha ọnụ zuru ụwa ọnụ (CC n'okpuru 30 ml / min / 1.73 sq.m ma ọ bụ mkpịsị ọbara serumine dị elu karịa 2 mg / 100 ml), ọgwụ kachasị elu kwa ụbọchị bụ 0.4 g.

Maka ndị ọrịa agadi, a na-eji 30% belata dose ahụ.

Na peritonitis, ọ nwere ike iji nchịkwa intraperitoneal nke ngwọta infusion na dose nke 50 mg 4 ugboro n'ụbọchị kwa 1 lita nke dialysate.

Mgbe nchịkwa iv gachara, enwere ike ịga n'ihu na ọnụ.

Mmekorita

N'ihi mbelata nke ọrụ microọdal oxidation Filiks na hepatocytes, ọ na-eme ka ntinye ahụ dịkwuo elu ma na-agbatị T1 / 2 nke theophylline (na xanthine ndị ọzọ, dịka ọmụmaatụ caffeine), ọgwụ ịba ọcha n'anya, na ọgwụ na-apụtaghị ìhè, ma na-enyere aka belata ndepụta prothrombin.

Mgbe ejikọtara ya na ọgwụ mgbochi ọgwụ ndị ọzọ (ọgwụ beta-lactam, aminoglycosides, clindamycin, metronidazole), a na-ahụkarị synergism, jikọtara ya na azlocillin na ceftazidime maka ọrịa kpatara Pseudomonas spp., Na meslocillin, azlocetilin l, wdg. ọgwụ mgbochi - maka oria streptococcal, yana isoxazolepenicillins na vancomycin - maka ọrịa staphylococcal, yana metronidazole na clindamycin - maka ọrịa anaerobic.

Na-akwalite mmetụta nephrotoxic nke cyclosporine, a na-achọpụta mmụba na serin creatinine, na ndị ọrịa dị otú a, ịchịkwa ihe ngosi a ugboro abụọ n'izu dị mkpa.

N'otu oge ahụ, ọ na-eme ka mmetụta nke anticoagulants na-apụtaghị ìhè pụta ìhè.

Nlekọta ọnụ na ọgwụ ndị nwere F, nwere ọgwụ a na-ejikwa ọgwụ antacid nwere Mg2 +, Ca2 + na Al3 + na-eduga n'ịbelata ciprofloxacin, yabụ, ekwesịrị ịkọ ya 1-2 awa tupu ma ọ bụ awa 4 mgbe ị takingụsịrị ọgwụ ndị ahụ dị n'elu.

NSAIDs (ewepu ASA) na - ebulite ohere nke ọdụdọ.

Didanosine na -ebelata nnabata nke ciprofloxacin n'ihi ịmepụta nke ogige dị iche iche na ya nwere Al3 + na Mg2 + nke dị na didanosine.

Metoclopramide na-agbakwu ngwa ngwa, nke na-eduga n'ịbelata oge ọ ruru Cmax.

Nchịkwa nke ọgwụ uricosuric na-eduga n'ibelata mkpochapụ (ihe ruru 50%) na mmụba na mkpokọta plasma nke ciprofloxacin.

Ngwunye infusion bụ ọgwụ dabara na ọgwụ mgbochi niile na ọgwụ ike na ahụike na-agbanweghị ike na gburugburu acidic (pH nke syproprolololo infusion bụ 3.9-4.5). Etinyekwala nsogbu maka ochichi iv na ihe ngwọta nwere pH karịa 7.

Ajuju, azịza, nyocha banyere ọgwụ Ciprofloxacin-AKOS

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.